"""trial"".""trial_id"""	"""trial"".""public_title"""	"""trial"".""recruitment_status"""	"""trial"".""study_type"""	"""trial"".""date_registration"""	"""trial"".""last_refreshed"""	"""trial"".""source_register"""	"""trial"".""id"""	"""trial"".""scientific_title"""	"""trial"".""scientific_title_native"""	"""trial"".""study_design"""	"""trial"".""study_phase"""	"""trial"".""allocation"""	"""trial"".""masking"""	"""trial"".""purpose"""	"""trial"".""date_enrolment"""	"""trial"".""primary_sponsor"""	"""trial"".""secondary_sponsors"""	"""trial"".""web_address"""	"""trial"".""target_size"""	"""trial"".""inclusion_criteria"""	"""trial"".""exclusion_criteria"""	"""trial"".""health_conditions"""	"""trial"".""interventions_summary"""	"""trial"".""contacts_summary"""	"""trial"".""results"""	"""trial"".""countries"""	"""trial"".""updated_on"""
RBR-10vf2byw	Effect of Gum Treatment on saliva and gingival fluid proteins in people with type 2 Diabetes	Not yet recruiting	Intervention	2026-05-09	<NULL>	<NULL>	9186	Effect of Periodontal Treatment on the proteomic profile of saliva and gingival fluid in type 2 diabetic patients with Periodontitis	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-02	Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	individuals over 30 years of age; with stage III-IV periodontitis; who provide saliva samples of at least 1 ml; who provide complete information on health-related issues; who have at least 15 teeth in their mouth; a minimum of 4 functional teeth and at least 3 adjacent teeth with interproximal papilla in at least one posterior quadrant of the maxilla; and who are able to read, understand, and sign an informed consent form.  For participants with diabetes mellitus, the inclusion criterion will be a minimum of 1.5 years since diagnosis	Smokers and former smokers who quit smoking less than 5 years ago, pregnant women, individuals who have undergone periodontal treatment in the last year, undergone antibiotic or anti-inflammatory therapy 3 months prior to inclusion in the study, or who have any other systemic disease, other than type 2 diabetes mellitus, that may alter the course of periodontal disease will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-4r22qwn	Study of the Drug Trimetazidine in the Treatment of People with Stroke	Not yet recruiting	Intervention	2026-05-08	<NULL>	<NULL>	9178	Use of Trimetazidine for The Treatment of Patient with Ischemic Stroke Randomized Double Blind Clinical Trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-07	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; of both sexes; with a diagnosis of ischemic stroke confirmed clinically or by neuroimaging; with symptom onset within 24 hours; who agree to participate by signing the informed consent form by the participant or legal representative	Participants with a diagnosis of hemorrhagic stroke; with more than 24 hours since symptom onset; with a diagnosis of Parkinson’s disease; with neoplasms; with diagnosis of encephalic infection; pregnant women; with a history of allergy to any component of the medications used in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-877g8fj	Use of Medical Ozone Gas in Tooth Whitening: Evaluation of Results and Sensitivity	Recruiting	Intervention	2026-05-08	<NULL>	<NULL>	9179	Evaluation of the Efficacy and Sensitivity of Dental Bleaching with Medical Ozone Gas Associated with Hydrogen Peroxide: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Colegiado de Odontologia	<NULL>	<NULL>	<NULL>	Patients of both sexes; age between 18 and 35 years; vital anterior teeth; teeth never bleached or restored; periodontal health; no history of spontaneous dental pain; non-use of desensitizing toothpaste; absence of dental cavitation; willingness to return for future evaluations during the research period	Smokers; pregnant or lactating women; participants with a history of dental sensitivity; presence of extensive restorations on anterior teeth; endodontically treated teeth; use of fixed orthodontic appliances; patients with periodontal problems; presence of caries or cracks in anterior teeth; continuous use of analgesics or anti-inflammatory drugs; participants with allergies to the components of the products used in the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-49myxws	Effect of endodontic treatment on serum levels of inflammatory markers of cardiovascular risk in individuals with chronic endodontic infection	Recruiting	Intervention	2026-05-08	<NULL>	<NULL>	9180	Biological mechanisms involved in the association between Asymptomatic apical periodontitis and the risk of Cardiovascular Diseases	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-11	Fundação Universidade Federal do Maranhão	<NULL>	<NULL>	<NULL>	Individuals aged 22 to 25 years; male and female; with a diagnosis of one or more teeth with asymptomatic apical periodontitis; with daily intake of added sugars above the level recommended by the World Health Organization (WHO) (≥10%) in the first phase of the study	Individuals with difficulty changing dietary habits; inability to follow the recommended diet due to religious reasons or disorders of mastication or swallowing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-8yqgf3c	Recovery of movement after Stroke using combined brain stimulation, interactive technologies and robotic therapy	Recruiting	Intervention	2026-05-08	<NULL>	<NULL>	9181	Analysis of the effects of neuromodulation using Transcranial Alternating Current Stimulation and Transcranial Magnetic Stimulation associated with Motor Imagery therapy, Brain-computer Interface, Functional Electrical Stimulation and Robotic Device in post-stroke rehabilitation	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-25	Centro de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Patients of both sexes, aged between 18 and 80 years, with cortical or subcortical Stroke resulting from a single event; presenting upper limb paralysis; with a minimum time of 6 months since Stroke onset; without acute psychiatric or neurological conditions other than Stroke; without cerebellar lesions or bilateral motor deficits; without pregnancy; without claustrophobia; without epilepsy or use of antiepileptic medication within the last 6 months; able to understand and follow instructions	The exclusion criteria are as follows: autonomic dysreflexia; pressure ulcers; thrombosis; peripheral neuropathy; severe aphasia; severe perceptual problems or other neurological conditions, such as Parkinson’s disease and dementia; history of upper limb surgery within the last 6 months; osteoporotic fractures within the last two years; severe osteoporosis; use of neuroleptic or anticonvulsant medications; skin lesions at the electrode placement site; severely impaired visual ability; history of more than one stroke episode; and refusal to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-98c73zq	Intra-Ainjection in the Treatment of Hip Osteoarthritis with Hyaluronic Acid	Recruiting	Intervention	2026-05-08	<NULL>	<NULL>	9182	Viscosupplementation in the Treatment of Hip Osteoarthritis: Do different Molecular Weights of Hyaluronic Acid Influence Functional Outcomes?	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-13	Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	dult patients; aged between 18 and 70 years; of both sexes; with symptomatic primary hip osteoarthritis; classified as grade 3 according to the Kellgren &amp; Lawrence scale	Patients who have previously undergone surgical treatment and have used other oral joint regeneration modulators for a period of less than 6 months;e.g., chondroitin sulfate, glucosamine, diacerein, and or collagen; patients with active inflammatory joint disease in the acute phase; e.g., rheumatoid arthritis, gout; patients with joint space over 2 millimetres; patients with avascular necrosis of the femoral head; patients with autoimmune disease or those unable to provide informed consent; all patients meeting these conditions will be categorically excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-3fbjdh7	Comparison of two clear aligner protocols for correcting Class II malocclusion	Recruiting	Intervention	2026-05-08	<NULL>	<NULL>	9183	Comparison of two treatment protocols for Class II malocclusion with clear aligners in patients with permanent dentition: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-05	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients of both sexes, aged between 14 and 25 years, presenting with a full permanent dentition up to the second molars; Class II, Division 1 malocclusion, with severity ranging from ¼ to ¾ based on the molar relationship	Class II, Division 2 malocclusion, or Class II malocclusions with severities greater than ¾ according to the molar relationship;Patients who have previously undergone orthodontic treatments involving premolar extractions; Patients with any systemic condition that may affect periodontal health, as well as those with facial deformities or syndromes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-9qsrzxv	How beetroot juice consumption can influence the physical performance of physically active individuals	Terminated	Intervention	2026-05-08	<NULL>	<NULL>	9184	Effects of beetrootjuice supplementation on the physical performance of physically active subjects	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-15	Universidade Federal de Lavras	<NULL>	<NULL>	<NULL>	aged between 18 and 59 years; have accumulated experience with resistance training for at least six months; perform a minimum of four training sessions per week	have any physical problems during the study that prevent them from carrying out the physical tests; start consuming other ergogenic resources during the study that may influence physical performance; adopting specific dietary regimes during the study that may affect physical performance; not completing all stages of the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-5zsczhf	Abiraterone at a low dose compared to the normal dose for patients with metastatic Prostate Cancer who have previously used Docetaxel	Recruitment completed	Intervention	2026-05-08	<NULL>	<NULL>	9185	Low-dose Abiraterone versus standard dose in Metastatic castration-resistant Prostate Cancer after Docetaxel: a randomized controlled trial in Brazil DUMONT	<NULL>	3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-01	Liga Norte Rio Grandense Contra o Câncer	<NULL>	<NULL>	<NULL>	Male patients over 18 years old; with metastatic castration-resistant prostate cancer; previously treated with Androgen Deprivation Therapy (ADT) and chemotherapy (CT) with docetaxel; chemically or surgically castrated; patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of menor ou igual a 1; patients must be able to take the medication orally as directed and be able to fast for at least 8 hours before and at least 2 hours after taking the medication in the full dose arm; for the low-dose arm (LOW), the patient must be able to take the medication concurrently with or within 30 minutes after a conventional low-fat breakfast	Those who have already used abiraterone; who have not previously undergone treatment with Androgen Deprivation Therapy (ADT) and/or docetaxel; who are not chemically or surgically castrated; who have an Eastern Cooperative Oncology Group (ECOG) performance status greater than or equal to 2; who are unable to take the medication as directed according to the study arm	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-94bknr7	Using Puppet Theater to encourage preschool children to eat more fruits and vegetables	Data analysis completed	Intervention	2026-05-07	<NULL>	<NULL>	9177	The influence of Audiovisual stimuli on children’s eating habits	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2018-03-12	Universidade Federal de Lavras (UFLA)	<NULL>	<NULL>	<NULL>	The study included children aged 2 to 6 years; of pre-school age; of both sexes; with the requirement that their legal guardians sign a consent form authorising the child’s participation in the study	Children outside the 2–6 age group; and where participation was not authorised by the child’s legal guardians	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-6yggjzm	Effect of light intensity on body responses during and after maximal progressive exercise.	Recruitment completed	Intervention	2026-05-06	<NULL>	<NULL>	9168	Effect of light intensity on cardiovascular and metabolic responses during and after maximal progressive exercise	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-02	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Men aged 20 to 40 years; normotensive; physically active; non-smokers; with a body mass index less than or equal to 30; without diseases; and not using medications; vitamins; or supplements on a regular basis.	Physically inactive or highly active individuals; hypertensive individuals; obese individuals; those with regular use of medications and those with any disease.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-5wz8jp7	Effects of a silver-based mouthwash on the treatment of gum inflammation caused by dental plaque	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9169	Effects of a Silver Nanoparticle-Based Mouthwash in the Treatment of Biofilm-Induced Generalized Gingivitis	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Evangelica de Goiás	<NULL>	<NULL>	<NULL>	Adult individuals (≥18 years) of both sexes will be included; systemically healthy (absence of diagnosed systemic diseases that may interfere with the inflammatory response or periodontal healing); with the presence of biofilm-induced gingivitis, characterized by: bleeding on probing (BOP) in &gt;30% of the evaluated sites, probing depth ≤3 mm in all sites, absence of clinical attachment loss and absence of radiographic bone loss; presence of at least 20 fully erupted permanent teeth (excluding third molars); capacity and willingness to understand and sign the Informed Consent Form and adhere to the study protocol.	The following will be excluded: pregnant or breastfeeding women; individuals with systemic diseases that may interfere with periodontal condition or response to treatment (e.g., uncontrolled diabetes mellitus, immunosuppressive diseases); use of antibiotics, anti-inflammatory drugs, or immunosuppressants in the last 3 months; previous history or current presence of periodontitis (according to clinical and radiographic criteria); presence of gingival diseases not induced by biofilm (e.g., drug-induced gingivitis, mucocutaneous diseases); smokers or former smokers who quit less than 12 months ago; presence of extensive prostheses or conditions that hinder periodontal evaluation; periodontal therapy performed in the last 6 months; need for antibiotic prophylaxis for routine dental procedures; known allergy to any components of the formulations used in the study; individuals who are legally incapacitated or have limitations that prevent compliance with the protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-22xgxrw	Assessment of the safety and benefits of joint injections with regenerative therapies in people with hemophilic arthropathy	Recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9170	Evaluation of the efficacy and safety of intra-articular infiltration of regenerative therapies in hemophilic arthropathy	<NULL>	1-2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-23	Universidade Federal do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; diagnosis of hemophilia A or B (moderate or severe); presence of hemophilic arthropathy in at least one joint (knee, ankle, elbow, shoulder, or hip); regular follow-up at a hemophilia treatment center; ability to provide informed consent; availability for follow-up assessments at baseline, 3 and 6 months	Presence of active local or systemic infection (including septic arthritis or cellulitis) at the time of intervention; recent orthopedic procedure in the target joint during the study period; immunosuppression; pregnancy or suspected pregnancy; significant joint instability or suspected fracture in the target joint; withdrawal of consent during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-33h2689	Home Exercise Program to improve balance in sedentary seniors	Recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9171	Home Exercise Program for Seniors	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-08	Departamento de Ciências do Movimento Humano- Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Elderly individuals aged between 60 and 80 years; both genders; with low levels of physical activity; independent in activities of daily living; preserved understanding for performing simple commands; no use of walking aids	Elderly individuals with severe mobility limitations; tumors; recent fractures or surgeries; neurological diseases; probable cognitive impairment; continuous use of psychotropic drugs; acute illnesses or any clinical condition that prevents the safe performance of the exercises	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-9wyb7ht	Use of Botulinum Toxin during hemorrhoidectomy surgery in an attempt to reduce postoperative pain and accelerate healing	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9172	Analysis of pain and wound healing in the treatment of hemorrhoidal disease with intraoperative botulinum toxin in the postoperative period of open hemorrhoidectomy: a randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Fundacao do ABC	<NULL>	<NULL>	<NULL>	Both sexes; hospitalized for elective hemorrhoidectomy; grade III or IV hemorrhoidal disease with or without anal skin tags; 18 years of age or older; in agreement and sign the informed consent form	History of egg allergy; presence of uremia or impaired renal function; use of antibiotics; use of steroidal anti-inflammatory drugs; use of magnesium sulfate-based calcium channel blockers; use of anticoagulants; preoperative fecal incontinence; presence of other diseases such as anorectal fissure or fistula associated with hemorrhoidal disease; clinical suspicion of neoplastic lesion of the anal canal or associated with hemorrhoidal disease; pregnant or breastfeeding women; performance of another surgical technique for the treatment of hemorrhoidal disease.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-3sfstb5	Physiological Responses to Sprint Interval Exercise Under Hypoxic Conditions in Trained Cyclists	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9173	Effects of Inter-effort Recovery Intermittent Hypoxia on Nitrate and Nitrite Bioavailability, Endothelial Function, Muscle Oxygenation, and Exercise Tolerance during Sprint Interval Training	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Male individuals; aged between 18 and 45 years; cyclists; born and residing at low altitude locations	History of metabolic or cardiovascular diseases; recent diagnosis of anemia; recent exposure to normobaric or hypobaric hypoxia; recent muscular injury; use of vasodilating foods or supplements	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-6rfj5vt	Bochecho com Camomila e Ácido Hialurônico para tratamento de feridas na boca causadas pela Radioterapia	Recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9174	Chamomile and Hyaluronic Acid therapy for the control of severe Oral Mucositis	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-17	Associação de Combate ao Câncer em Goiás	<NULL>	<NULL>	<NULL>	Participants of both genders; over 18 years of age; with head and neck cancer; who will undergo radiotherapy or chemoradiotherapy with a minimum total dose of 60 Gy and a minimum daily dose of 2 Gy; performance status score between 0 and 2	Participants with salivary gland tumors; those with Sjögren&apos;s syndrome; those with infectious diseases; individuals undergoing palliative radiotherapy; those with a history of previous cancer treatment in the head and neck region; participants diagnosed with lymphoma; those diagnosed with melanoma or skin cancer	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-9ctfqpt	Influence of a Flexible Exoskeleton on the ability to perceive objects by touch in children with cerebral palsy	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9175	Influence of a Tensegrity-Based Exoskeleton on haptic perception in children with Cerebral Palsy (CP)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Programa Pós-Graduação em Ciências da Reabilitação (PPGCR) da Universidade Federal de Minas Gerais (UFMG)	<NULL>	<NULL>	<NULL>	Children aged between eight and fourteen years and eleven months; of both sexes; with a diagnosis of cerebral palsy; classified at levels I or II of the Gross Motor Function Classification System (GMFCS), which is a system for classifying gross motor function; classified at levels I or II of the Manual Ability Classification System (MACS), which is a system for classifying manual ability; who have not undergone orthopedic surgery in the last six months; who are able to understand and follow verbal instructions	Children who are unable to complete the proposed assessment or perform the requested tasks during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-4k8dp49	Exercise Program for people with Chagas Disease affecting the heart: a study with randomly assigned groups	Not yet recruiting	Intervention	2026-05-06	<NULL>	<NULL>	9176	Evaluation of the effects of Aerobic Physical Training in Chronic Chagas Cardiomyopathy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-10	Escola de Educação Física, Fisioterapia e Terapia Ocupacional (EEFFTO) da Universidade Federal de Minas Gerais (UFMG)	<NULL>	<NULL>	<NULL>	Adults (aged 18 years or older); both sexes; confirmed Chagas disease based on two distinct serological tests (e.g., indirect immunofluorescence, enzyme-linked immunosorbent assay (ELISA), or hemagglutination); evidence of myocardial involvement defined by segmental or global systolic dysfunction on echocardiography or by electrocardiographic abnormalities suggestive of Chagas cardiomyopathy; left ventricular ejection fraction (LVEF) higher than 40%; New York Heart Association (NYHA) functional class I or II; recruitment at the Chagas disease outpatient clinic at the Hospital das Clínicas of the Federal University of Minas Gerais (UFMG) and at participating centers of the Federal University of Triângulo Mineiro (UFTM) and the Federal University of the Jequitinhonha and Mucuri Valleys (UFVJM)	Patients presenting with another etiology for myocardial dysfunction, such as alcoholism, previous myocardial infarction, known coronary artery disease, use of cardiotoxic agents or illicit drugs, peripartum cardiomyopathy, primary valvular heart disease, and pericardial disease, will be excluded. Patients with comorbidities that impair functional capacity, such as Chronic obstructive pulmonary disease (COPD) severe, severe liver disease, collagen vascular disease, and untreated thyroid dysfunction, will also be excluded. Coronary artery disease (CAD) must be ruled out by cardiac catheterization in patients who present ischemic perfusion defects on myocardial perfusion scintigraphy and have three or more risk factors for atherosclerotic coronary artery disease. Finally, individuals presenting physical limitations (orthopedic or neurological) to aerobic exercise on a treadmill and/or walking, or any contraindication to moderate-intensity aerobic physical activity, will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:20
RBR-32q9fnd	Therapeutic effect of an adhesive on oral ulcers: a randomized clinical trial	Data analysis completed	Intervention	2026-05-05	<NULL>	<NULL>	9167	Efficacy of a therapeutic adhesive in traumatic oral ulcers: a randomized clinical trial	<NULL>	3, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-01	CCS - Centro de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Patients aged 5 years, any genders or older treated at the State University of Maringá dental clinic; walk in patients or those from partner private clinics; individuals presenting painful symptoms associated with oral ulcers; clinical diagnosis confirmed by the principal investigator; patients willing and able to comply with all aspects of the study protocol; voluntary signing of the informed consent form, and for patients under 18 years of age, the form must be signed by a legal guardian	Patients with systemic diseases presenting oral manifestations in the form of ulcers; diabetic patients; pregnant women; children under 5 years of age; patients with oral infections of fungal, viral, or bacterial origin; individuals allergic to any component of the products used; patients using medications for the treatment of ulcers at the time of inclusion; patients using ill-fitting prostheses; presence of restorations with sharp edges; orthodontic appliance users; presence of any local interfering factor capable of causing chronic lesions; participants who used analgesics during the study were also excluded at a later stage	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-72mwpg5	Use of Photobiomodulation after lingual frenulum Surgery with High-power Diode Laser. Clinical, randomized, blinded study	Recruitment completed	Intervention	2026-05-04	<NULL>	<NULL>	9162	Evaluation of Photobiomodulation uses after lingual frenulum Surgery with High-power Diode Laser. Clinical, randomized, blinded study	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-26	Faculdade de Odontologia da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients aged 0 to 1 year, of both sexes, and regardless of race or social class; Patients diagnosed with ankyloglossia according to one of those techniques: TABBY technique (total score equal to 0 to 3) and Lingual Frenulum Evaluation Protocol for Infants (Tongue-tie Test) (Clinical exam: total score 1 to 4 ≥ 7; total score of clinical exam and medical history ≥ 13); Patients whose feeding method is breastfeeding, either naturally or via artificial nipple, with or without the introduction of complementary feeding	Presence of systemic problems and insufficient score on diagnostic tests (Tongue-tie and Breastfed Babies Assessment Tool and Tongue Frenulum Assessment Protocol in Babies)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-4rq6jrk	Photodynamic therapy as an aid in the treatment of oral candidiasis in patients admitted to the intensive care unit	Recruitment completed	Intervention	2026-05-04	<NULL>	<NULL>	9163	Antimicrobial photodynamic therapy as an adjunctive treatment for oral candidiasis in patients hospitalized in the intensive care unit: a randomized clinical trial	<NULL>	2, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-10	Departamento de Odontologia	<NULL>	<NULL>	<NULL>	Patients with a clinical diagnosis of oral candidiasis admitted to the intensive care unit of the study site;Patients aged 18 years or older men and women;Patients who have been hospitalized in the  intensive care unit for a minimum period of 48 hours	Pregnant and breastfeeding women;Patients whose mouth opening is insufficient to allow proper intraoral clinical examination as well as the procedures required for antimicrobial photodynamic therapy;Patients with invasive candidiasis and candidemia	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-8g4k2gd	Use of lavender and lemongrass aromatherapy to reduce pain and anxiety during labor	Recruiting	Intervention	2026-05-04	<NULL>	<NULL>	9164	Effectiveness of lavender and lemongrass aromatherapy on pain and anxiety in women in labor	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Escola de Enfermagem da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Women aged between eighteen and forty years, regardless of parity; term pregnancy between thirty seven weeks and forty one weeks and six days, with a single, live fetus in cephalic presentation; active labor, defined by cervical dilation greater than or equal to five centimeters, confirmed by vaginal examination, and the presence of at least two effective uterine contractions lasting greater than or equal to forty seconds within ten minutes; pain score greater than or equal to four on the Visual Analog Scale VAS and anxiety level greater than or equal to thirty on the &quot;State Trait Anxiety Inventory State&quot; at the pre intervention moment; no language barriers that would prevent understanding of the Portuguese language	Presence of obstetric comorbidities or systemic conditions, such as hypertensive disorders, metabolic disorders, hemorrhagic conditions, pulmonary diseases (e.g., rhinitis, asthma), heart diseases, coagulation disorders, autoimmune diseases, among others; prior use of pharmacological analgesia before the intervention (e.g., epidural analgesia, nitrous oxide, scopolamine butylbromide); prior use of anxiolytics or antidepressants, regardless of pharmacological class; presence of olfactory disorders that may interfere with the administration of essential oils; known allergies to essential oils or hypersensitivity reactions occurring during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-4ddjxh2	Polymyxin monotherapy versus polymyxin-based combination therapy for the treatment of pneumonia and bloodstream infections caused by carbapenem-resistant Acinetobacter: a non-randomized clinical trial.	Recruiting	Intervention	2026-05-04	<NULL>	<NULL>	9165	Treatment of infections caused by carbapenem-resistant Acinetobacter sp.: a clinical trial	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-01	Santa Casa de Misericórdia de Limeira	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; both sexes; hospitalized, with identification of carbapenem-resistant Acinetobacter spp. in blood cultures or tracheal secretion cultures; who meet diagnostic criteria for ventilator-associated pneumonia (VAP) or bloodstream infection (BSI), according to definitions from the Epidemiological Surveillance Center of São Paulo (CVE-SP); who agree to participate in the study by signing the Informed Consent Form (ICF) or through a legal representative	Patients who do not consent to participate in the study or whose Informed Consent Form (ICF) is withdrawn; patients transferred to a non-participating institution; patients with isolation of carbapenem-susceptible Acinetobacter spp.; cases in which the isolate is considered colonization or contamination without indication for antimicrobial treatment, according to clinical evaluation; patients with insufficient clinical data for analysis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-2dwdry5	Photobiomodulation Therapy in the treatment of Tinnitus	Recruiting	Intervention	2026-05-04	<NULL>	<NULL>	9166	Effects of Photobiomodulation Therapy in the treatment of Tinnitus	<NULL>	n/a, single-arm-study, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade do Estado da Bahia	<NULL>	<NULL>	<NULL>	Aged 18 years or older; both genders; present a pure-tone average ≤ 50 dB HL; and report constant tinnitus for at least six months; Individuals currently using ototoxic medication will be excluded from the study	Participants will be excluded if they present neurological or cognitive impairments that prevent adequate understanding of the study procedures; a history of acute or chronic otologic disorders; tympanic membrane perforation or otorrhea; history of meningitis; conductive or mixed hearing loss; somatosensory tinnitus influenced by temporomandibular disorders (TMD); or if they have undergone any specific tinnitus treatment within the month prior to study enrollment. Individuals presenting any contraindication to photobiomodulation therapy will also be excluded, including tumors or neoplasms, pacemakers or other electronic implants, pregnancy, use of retinoic acid or vitamin A derivatives (retinoic acid, retinol A, tretinoin, isotretinoin), antibiotic therapy with tetracycline, history of photosensitivity, use of anticoagulant medication, or history of thrombosis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-5kjjw52	Difficulties and assessment of maternal confidence with breastfeeding: randomized controlled clinical trial	Recruitment completed	Intervention	2026-05-01	<NULL>	<NULL>	9161	Challenges and assessment of maternal self-efficacy with breastfeeding: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-05	Universidade Federal de Sergipe- Campus Lagarto	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; be literate; be at least 28 weeks pregnant; have at least one telephone contact	Postpartum women who, after giving birth, are not in a position to breastfeed and/or who are unable to breastfeed for more than 24 hours; postpartum women with diagnosed mental disabilities/disorders and language or speech disorders with  International Classification of Diseases (ICD), who have significant difficulties in verbal communication to understand and/or respond adequately to questions during interviews	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-9d2vqzn	Use of an energy-based device to relieve intimate symptoms of menopause in women with breast cancer	Recruiting	Intervention	2026-04-30	<NULL>	<NULL>	9157	Efficacy of Fractional Microablative Radiofrequency in Genitourinary Syndrome of Menopause in Women with Breast Cancer: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	<NULL>	<NULL>	<NULL>	Women; aged between 18 and 65 years; absence of menstruation for more than 12 months; breast cancer under treatment or post-treatment; complaints of genitourinary syndrome of menopause, including vaginal, sexual, and urinary symptoms; complaints of urinary incontinence; availability to attend therapy sessions on the scheduled date and location for the treatment	Use of vaginal moisturizers in the last 30 days; active urinary tract or vaginal infection; presence of pelvic organ prolapse classified as stage III and IV; cognitive or psychiatric impairment that prevents understanding of the treatment instruments used	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-10vzd55h	Use of a new synthetic membrane in surgery for ocular surface reconstruction	Not yet recruiting	Intervention	2026-04-30	<NULL>	<NULL>	9158	Polydioxanone membrane for guided conjunctival tissue reconstruction: an experimental model	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Banco de Olhos de Sorocaba	<NULL>	<NULL>	<NULL>	Participants of both genders; age 18 years or older; presence of one of the following ocular surface tumors: conjunctival nevus, conjunctival melanoma, ocular surface squamous neoplasia, or primary acquired melanosis of the conjunctiva; best corrected visual acuity better than 20/40 in the contralateral eye; provision of written informed consent	Presence of corneal disease in the affected eye, including previous opacities, scars, dystrophies, or infections; systemic diseases with ocular involvement; pregnancy; previous ocular surface surgery in the affected eye; allergy to any medication used in the postoperative period; glaucoma or ocular hypertension, eyelid disease, or lacrimal disease in the affected eye; any ophthalmologic condition or disease in the contralateral eye other than low refractive error; presence of a small lesion allowing primary conjunctival closure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-7hvd26h	The effect of fecal transplant in patients with intestinal inflammation	Recruitment completed	Intervention	2026-04-30	<NULL>	<NULL>	9159	Clinical efficacy of Intestinal Microbiota Transplantation in patients with Inflammatory Bowel Disease	<NULL>	n/a, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-04	Universidade Federal de Alagoas	<NULL>	<NULL>	<NULL>	Adults aged between 18 and 75 years; Confirmed diagnosis of ulcerative colitis (UC) or Crohn’s disease (CD) based on clinical, endoscopic, and histological criteria, and who have not used prebiotics, probiotics, or synbiotics in the 6 months prior to data collection; Stable maintenance therapy for at least 3 months prior to inclusion; Ability to provide informed consent	Having undergone any gastrointestinal surgery in the last 6 months; Severe anemia; Chronic obstructive pulmonary disease; Life expectancy of less than 3 months; Patients diagnosed with sleep apnea; American Society of Anesthesiologists (ASA) score greater than or equal to three; Patients unable to undergo endoscopy/colonoscopy; Use of antibiotics in the four weeks prior to inclusion; Pregnancy or breastfeeding; Significant hepatic, renal, or cardiac comorbidities; History of intestinal resection greater than 40 cm; Active infection or malignancy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-10jc56n7	Study on the cost-benefit of a barbatimão-based product in controlling microorganisms and promoting wound healing.	Not yet recruiting	Intervention	2026-04-30	<NULL>	<NULL>	9160	Cost-effectiveness of an active ingredient based on Stryphnodendron barbatiman on microbial load and tissue repair process in wounds: Translational research	<NULL>	3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Universidade Federal Fluminense	<NULL>	<NULL>	<NULL>	Be over 18 years of age, regardless of gender; have a chronic wound larger than 2 cm² and smaller than 100 cm²; have a wound that has been present for more than 12 weeks; have a wound without signs of infection (PEDIS 1 or NERDS/STONES negative); and be available to attend the outpatient clinic weekly.	Pregnant and breastfeeding women; Undergoing immunosuppressive and/or antimicrobial therapies; Suspected or confirmed oncological disease associated with the wound; Suspected or confirmed wound infection; People with visual and/or hearing impairments or who do not have full autonomy.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-9n3dqnn	Comparison of Vitamin D Supplements in Obese and Healthy Women	Recruiting	Intervention	2026-04-29	<NULL>	<NULL>	9150	Comparison of the effects of supplementation with calcifediol, cholecalciferol, or placebo on plasma vitamin D metabolites and biomarkers of bone metabolism in obese and normal-weight women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women with obesity (BMI greater than or equal to 30 kg/m²), aged 18 to 60 years, followed at the Obesity Outpatient Clinic. Control group: women with BMI between 18.5 and 24.9 kg/m², aged 18 to 60 years	Age under 18 years; pregnancy or lactation; intestinal malabsorptive disorders; use of medications that interfere with vitamin D metabolism or absorption (corticosteroids, anticonvulsants, isoniazid, antiretrovirals, antifungals, orlistat, cholestyramine); primary/tertiary hyperparathyroidism; hypoparathyroidism; osteoporosis; osteomalacia; rickets; thyrotoxicosis; chronic kidney disease (creatinine clearance under 45 mL/min); history of cancer; chronic liver failure; patient refusal. Use of any commercial vitamin D formulations within the past 2 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-54px2gr	Effect of a Toothpaste with REFIX Technology on Tooth Sensitivity and Color Maintenance in the the treatment of darkned teeth	Recruiting	Intervention	2026-04-29	<NULL>	<NULL>	9151	Effect of a dentifrice with REFIX technology on tooth sensitivity and color maintenance after bleaching with 10% hydrogen peroxide: a triple-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-20	Universidade Federal da Paraíba	<NULL>	<NULL>	<NULL>	Volunteers aged 18 years or older. Good general and oral health condition, absence of carious lesions, gingivitis or periodontitis. Presence of six maxillary anterior teeth with shade A2 or darker according to the Vita Classical shade guide	Previous history of dental bleaching treatment. Pre-existing dentin hypersensitivity. Presence of dental prostheses or orthodontic appliances. Restorations in the maxillary anterior teeth. Presence of non-carious cervical lesions. Endodontic treatment in the maxillary anterior teeth. Teeth with tetracycline staining or dental fluorosis. Visible enamel cracks. Parafunctional habits such as bruxism or smoking. Pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-7k4zy9v	Mental health guidance for people undergoing cancer treatment	Recruitment completed	Intervention	2026-04-29	<NULL>	<NULL>	9152	Mental health education: a psychoeducational guide for oncology patients undergoing treatment	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-27	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	<NULL>	<NULL>	<NULL>	Women aged between 18 and 75 years, diagnosed with breast cancer, undergoing oncological treatment, able to understand Portuguese language, and who agree to participate in the study.	Patients with pre-existing severe psychiatric disorders, inability to understand Portuguese language, or who have previously received similar psychoeducational intervention.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-9n5rcm9	Evaluation of the efficacy of intralesional therapies in the treatment of hematomas and scars after submental liposuction and facelift	Terminated	Intervention	2026-04-29	<NULL>	<NULL>	9153	Evaluation of the efficacy of intralesional therapies in the treatment of ecchymosis hematomas and hypertrophic scars keloids after mechanical submental liposuction and facelift a randomized double blind longitudinal clinical study	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Centro Universitário Ingá	<NULL>	<NULL>	<NULL>	Inclusion criteria comprise adult patients aged between 40 and 70 years, of both sexes, with scars ranging from 3 to 14 months in duration and measuring between 0.5 and 12 cm in maximum dimension.	Patients with specific contraindications to the medications, infections or skin pathologies near the scar, previous intralesional treatments, pregnancy or lactation, diabetes mellitus, hypertension, cardiovascular diseases, chronic kidney disease, a history of allergy to the study medications, or prior use of these medications for other medical conditions will not be included.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-4435k8w	Evaluation of the efficacy of the combination of botulinum toxin and hyaluronic acid for chin augmentation in patients with class II malocclusion	Terminated	Intervention	2026-04-29	<NULL>	<NULL>	9154	Evaluation of the efficacy of combined injections of botulinum toxin and hyaluronic acid for chin augmentation in Brazilian patients with class II malocclusion a randomized double blind longitudinal clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-15	Centro Universitário Ingá	<NULL>	<NULL>	<NULL>	Individuals of both sexes aged between 18 and 50 years, presenting moderate to severe chin retrusion, defined as grades 2 or 3 according to the Chin Retrusion Scale of Allergan, confirmed by standardized clinical assessment	Individuals with a history of prior chin correction using non permanent fillers or permanent implants, as well as individuals presenting any contraindication to injections, will not be eligible to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-5dknb4r	Use of genetics and artificial intelligence to personalize medical cannabis treatment for anxiety and depression	Not yet recruiting	Observational	2026-04-29	<NULL>	<NULL>	9155	Medicinal cannabis, personalized intelligence: artificial intelligence and pharmacogenomics in the treatment of anxiety and depression in the Brazilian public health system	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Adults aged 18 or older; of both sexes; residing in the state of Santa Catarina; with a medical diagnosis of anxiety disorder and/or depressive disorder according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5); regularly using full-spectrum medicinal cannabis oil prescribed by their attending physician; cognitively capable of understanding the study procedures and providing free and informed consent	Individuals with medical contraindications to the use of medicinal cannabis; unable to provide the necessary saliva sample; lacking the minimum clinical data required for analysis; or who refuse to participate in the research or sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-73mkk84	Ursolinol Supplement for Weight Loss in Overweight Adults	Recruitment completed	Intervention	2026-04-29	<NULL>	<NULL>	9156	Effects of oral supplementation of URSOLINOL on body weight reduction and body composition alteration in overweight or obese adults: a randomized, double-blind, placebo-controlled trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Universidade Federal de Viçosa	<NULL>	<NULL>	<NULL>	Participants in this study will be adult individuals of both sexes, residing in Viçosa/MG or surrounding areas, who have not received nutritional follow-up in the past six months and who present health risks associated with obesity, according to the following criteria: Body fat percentage ≥ 20% for men and ≥ 30% for women; Age between 30 and 60 years; Waist circumference (men ≥ 90 cm, women ≥ 80 cm), plus at least two of the following criteria: High-density lipoprotein (HDL) cholesterol (men ≤ 40 mg/dL, women ≤ 50 mg/dL); triglycerides ≥ 150 mg/dL; Blood pressure ≥ 130/85 mmHg.	Pregnant or lactating women, as well as postmenopausal women, will not be included; athletes; shift workers; individuals with physical and/or intellectual disabilities; those with food intolerances or allergies; individuals with diabetes mellitus; autoimmune diseases or those using immunosuppressive drugs (e.g., HIV, rheumatoid arthritis, lupus); hormonal disorders (hyperthyroidism or hypothyroidism, Cushing’s syndrome); gastrointestinal diseases or disorders (gastritis, ulcers, esophagitis, dysphagia, chewing difficulties); individuals with inflammatory bowel diseases (ulcerative colitis, Crohn’s disease, diverticulitis, celiac disease, irritable bowel syndrome); hepatic diseases (liver failure, hepatitis, cirrhosis), renal diseases (chronic kidney disease), pancreatitis, cardiovascular diseases (angina, acute myocardial infarction, congestive heart failure), eating disorders (anorexia, bulimia, binge eating disorder); cancer; recent infectious episode within the past month; history of illicit drug use and/or alcohol consumption &gt; 21 and &gt; 14 units/week for men and women, respectively; previous bariatric surgery; body weight instability (≥ 5% change in usual body weight) in the last three months; adherence to vegan, vegetarian, or restrictive diets; use of anti-inflammatory drugs, corticosteroids, antipsychotics, or antidepressants that may affect appetite and/or energy metabolism; use of vitamin, mineral, or omega-3 supplements; and use of fiber supplementation (e.g., psyllium, inulin).	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-296z9hd	Effect of 12 weeks of a training program with muscle strength exercises in open and closed kinetic chain on postural control performance, muscle activation and lower limb muscle power	Not yet recruiting	Intervention	2026-04-28	<NULL>	<NULL>	9146	Effect of a 12 week training program with muscle strength exercises in open and closed kinetic chain on postural control performance, muscle activation and lower limb muscle power: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Centro de Educação Física e Desportos da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Healthy older adults; Age equal to or greater than 60 years; Residents of João Neiva, Espírito Santo, Brazil;Young adults; Age between 18 and 35 years; Healthy	Neurological diseases; Dependent gait; Altered cognitive functions; Depressive symptoms; Auditory or vestibular impairment; Inability to perform strength training	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-75s78rj	Learning safe surgery with virtual reality: how undergrad students retain knowledge better	Not yet recruiting	Intervention	2026-04-28	<NULL>	<NULL>	9148	Training in safe surgery using virtual reality for knowledge retention among undergraduate students at a public university	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-30	Fundação Universidade Federal de São João Del Rei - C. C. Oeste Dona Lindu	<NULL>	<NULL>	<NULL>	Nursing students; both male and female; aged at least 18 years; who have completed courses covering surgical care content	Students on leave from their undergraduate studies for any reason at the time of data collection will be excluded from the sample	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-10jjsm26	Evaluation of pelvic muscle strength in women during treatment for cervical cancer	Recruiting	Observational	2026-04-28	<NULL>	<NULL>	9149	Oncological treatment and the functionality of the pelvic floor muscles (PFM) in women with Cervical Cancer: prospective cohort	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo.	<NULL>	<NULL>	<NULL>	Women with a confirmed diagnosis of cervical cancer; patients with an indication for oncological treatment (surgery, radiotherapy, chemotherapy, or brachytherapy); age 18 years or older; ability to understand and sign the Informed Consent Form (ICF)	Patients with metastatic tumors with exclusive indication for palliative treatment; women unable to undergo functional clinical examination (digital palpation); presence of cognitive conditions that prevent the understanding of questionnaires; refusal to participate in any stage of data collection	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-5z3x6d6	Study of saliva, pain, and substances in the mouth of patients with tooth infection	Recruitment completed	Observational	2026-04-27	<NULL>	<NULL>	9140	Analysis of salivary flow and buffering capacity, pain perception, and salivary biochemical parameters in patients with Chronic Apical Abscess	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-17	Faculdade de Odontologia de Araçatuba - Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Participants of both sexes; minimum age of 18 years; systemically healthy individuals; absence of periodontitis. Patients with chronic apical abscess; absence of pain; presence of periapical lesion; presence of sinus tract; teeth without direct pulp exposure to the oral cavity; teeth suitable for rubber dam isolation; teeth from any dental group. For the control group asymptomatic individuals; absence of carious lesions; absence of inflammatory lesions; absence of neoplastic lesions	Presence of systemic diseases; continuous use of medications; history of chemotherapy or radiotherapy; use of antibiotics within the three months prior to sample collection; current or past smoking; ongoing orthodontic treatment; presence of periodontal disease. For the chronic apical abscess group presence of teeth with vital pulp; absence of periapical lesion; absence of sinus tract; severely destroyed crown preventing proper isolation; pulp tissue exposed to the oral cavity; history of previous endodontic treatment in the tooth of interest. For the control group presence of carious lesions; presence of inflammatory lesions; presence of neoplastic lesions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-2gt5t4c	Blood-derived eye drops in liquid and powder form for the treatment of severe dry eye	Recruitment completed	Intervention	2026-04-27	<NULL>	<NULL>	9141	Use of frozen and lyophilized blood components for the treatment of severe dry eye	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-06	Hospital de Clínicas da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Patients with a diagnosis of severe mixed dry eye; Patients with a therapeutic indication for the use of topical blood components on the ocular surface; Patients who agree to participate in the study and sign the Informed Consent Form (ICF); Minimum age of 18 years; Both sexes	Patients with an active ocular infection at the time of data collection; Pregnant or lactating patients; Patients who have had changes in pre-existing topical eye medications after the start of the study; Patients unable to attend all evaluations required by the study protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-735p6cp	Evaluation of an App for Prescribing Home-Based Exercises for Common Musculoskeletal Conditions	Not yet recruiting	Intervention	2026-04-27	<NULL>	<NULL>	9142	Feasibility and Effectiveness of a Digital Tool for Prescribing Home-Based Physical Exercises for Prevalent Musculoskeletal Conditions	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Individuals with shoulder impingement syndrome; or nonspecific low back pain; or greater trochanteric pain syndrome; or knee osteoarthritis; or patellofemoral pain syndrome; or Achilles tendinopathy; under regular follow-up at Hospital de Clínicas – Unicamp; who are not undergoing physiotherapy; and who have no plans to start physiotherapy in the next three months	Volunteers who do not have a smartphone; incompatible smartphone; a prosthesis that prevents performing the exercises; decompensated psychiatric disorder; under 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-6r876vt	Effect of simulation versus lecture on surface cleaning and disinfection: a quasi-experimental study	Other	Intervention	2026-04-27	<NULL>	<NULL>	9143	Effect of simulation training and interactive lecture-based teaching on the surface cleaning and disinfection process	<NULL>	n/a, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Mato Grosso do Sul	<NULL>	<NULL>	<NULL>	Nursing and cleaning professionals actively and directly involved in the cleaning and disinfection process at the medical clinic unit during the study period; professionals of both genders; professionals aged 18 years or older; professionals working on a 12 by 36-hour shift schedule (twelve hours of work followed by thirty-six hours of rest), covering both even and odd shifts	Professionals who are not directly responsible for the cleaning and disinfection process due to being in managerial or administrative roles; interns and students from technical or undergraduate courses	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-6hpbpc3	Comparison of electric currents in pain relief after cesarean section	Recruiting	Intervention	2026-04-27	<NULL>	<NULL>	9144	Efficacy between medium and low frequency Electrotherapeutic Currents in relieving post-cesarean pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-15	Instituto de Saúde e Biotecnologia - Universidade Federal do Amazonas	<NULL>	<NULL>	<NULL>	Women; aged 18 years or older; subjected to elective or urgent cesarean section; hemodynamically stable; with preserved cognition and able to respond to the researchers&apos; questions	Women with a pacemaker; allergy to electrodes; neurological disorders; infection at the therapy application site; postpartum women with any post-cesarean complications such as hemorrhage, infection, or bleeding at the incision; communication difficulties that make it impossible to answer the research questions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-29x2d9b	How the use of e-cigarettes can affect the oral health and quality of life of young adults.	Recruiting	Observational	2026-04-27	<NULL>	<NULL>	9145	Effects of electronic cigarettes on oral health and oral health-related quality of life: a cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-05	Faculdade de Odontologia da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Adults aged 18 to 35 years at the time of inclusion; both genders; residing in the Greater São Paulo Metropolitan Region; who agree to participate in the research and sign the Informed Consent Form	Refusing to participate in the study; being a conventional smoker; being a dual user (conventional cigarettes and electronic cigarettes); having systemic diseases that affect oral conditions, such as HIV infection or diabetes mellitus; being completely edentulous	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-4f3rmkt	Effect of filler plastic surgery with Hyaluronic Acid on facial beauty: future research	Recruitment completed	Intervention	2026-04-27	<NULL>	<NULL>	9147	Impact of Hyaluronic Acid Profileplasty on aesthetic perception: a prospective study	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Santo Amaro	<NULL>	<NULL>	<NULL>	Adults between 18 and 55 years old. Both sexes. Good general health. Class I or II (A/B) according to the Angle classification. Agree to and sign the terms of the Informed Consent Form (ICF). Absence of prior facial aesthetic interventions within the last 12 months	Allergy to hyaluronic acid. Allergy to anesthetics such as lidocaine. Marked facial asymmetries. Previous facial surgeries. Coagulation disorders. Autoimmune diseases. Metabolic diseases. Pregnant and lactating women. Active infections, skin lesions, or recent herpes in the treatment area. Presence of permanent materials (PMMA, silicone, and facial prostheses). Class III according to the Angle classification. Recent use of facial fillers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-10tkjh3t	Effectiveness and durability of ready-to-use botulinum toxin A formulations (Relfydess and Alluzience) for treating moderate to severe frown lines: a randomized controlled clinical trial	Recruitment completed	Intervention	2026-04-26	<NULL>	<NULL>	9139	Efficacy and durability of liquid formulations of botulinum toxin type A, Relabotulinumtoxin-A (Relfydess) and RTU Abobotulinumtoxin-A (Alluzience), in the treatment of moderate-to-severe dynamic glabellar lines: a randomized, controlled, triple-blind clinical study	<NULL>	3, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Centro Universitário Uningá	<NULL>	<NULL>	<NULL>	"female patients aged between 25 and 50 years; presence of dynamic glabellar lines involving the procerus and corrugator muscles; no botulinum toxin injections within the last year for aesthetic or therapeutic purposes in any body region; moderate to severe glabellar lines according to the 5-point Merz scale; and no aesthetic procedures performed in the upper third of the face within the last year.
3. Moderate to severe glabellar lines according to the 5-point Merz scale;
4. No other aesthetic procedures performed in the upper third of the face within the last year."	receipt of tetanus or COVID-19 vaccination within the last three months prior to study initiation; presence of autoimmune diseases; pregnancy or breastfeeding; presence of neuromuscular disorders, such as myasthenia gravis or Lambert–Eaton syndrome; current use of medications affecting neuromuscular junctions; engagement in high-intensity physical exercise; and refusal or inability to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-10rr2p5d	Laser therapy for Pain in individuals with Knee osteoarthrosis	Recruitment completed	Intervention	2026-04-25	<NULL>	<NULL>	9137	Photobiomodulation with Single or Cluster Device in Pain intensity in patients with Severe knee osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade São Francisco	<NULL>	<NULL>	<NULL>	Age between 55-85 years old; have osteoarthritis in the knee joint (unilateral or bilateral) lasting at least 2 years; present pain in at least three of the following actions: going up and down stairs, kneeling, sitting and standing, running, and standing for 2 minutes; a Numerical Pain Scale (NPS) score above 4 points (moderate); and a Kellgren-Lawrence classification of grade IV.	Uncontrolled diabetes mellitus; untreated systemic arterial hypertension; neurological deficits (motor or sensory); history/diagnosis of cancer; fibromyalgia; previous hyaluronic acid injection (and/or invasive therapies); or not accepting participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-5jbrjcb	Use of virtual nursing rounds at night to prevent falls in hospitalized older patients	Not yet recruiting	Intervention	2026-04-25	<NULL>	<NULL>	9138	Virtual hourly intentional nursing rounds in hospitalized elderly patients during the nighttime: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	<NULL>	<NULL>	<NULL>	Hospitalized patients aged between 65 and 100 years; patients admitted to geriatric or medical-surgical units, with or without a caregiver; patients who agree to participate and sign the informed consent form	Patients who refuse to participate; patients previously selected for continuous video monitoring according to institutional criteria; patients classified as bedridden or restricted to bed	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-4p5b4xb	Effects of circuit-based resistance training on frailty and functional capacity in older adults	Recruitment completed	Intervention	2026-04-24	<NULL>	<NULL>	9133	Circuit Resistance Training: an intervention model to improve functional capacity and frailty status in older adults	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Participants must not have engaged in any structured physical activity over the past year; must self-identify as female or male; must be aged 60 years or older; must live near the Sports Center where the experiment will be conducted; must agree to participate only in the intervention as their daily physical practice during the 12-week period; must score between 1 and 5 on the criteria used to assess frailty status; and must be able to complete the Informed Consent Form in accordance with Brazilian National Health Council (CNS) Resolution No. 466/2012, as well as be fit to participate fully in the study	Older adults presenting with severe frailty; severe and unstable clinical conditions (cardiovascular, respiratory, neurological, or orthopedic) within the last month and at the time of recruitment/intervention; cognitive impairment that prevents understanding the Informed Consent Form (ICF) and following instructions; recent falls with serious injuries and/or postural instability that precludes exercise practice; rapid and excessive weight loss; participants who have engaged in structured physical activity within the last 12 months; dependence on mobility aids that may hinder performance of the training; participation in other studies; refusal to provide informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-10dxkjkr	Remote workshops for cognitive stimulation in the elderly.	Data analysis completed	Intervention	2026-04-24	<NULL>	<NULL>	9134	Teleworkshops for cognitive stimulation in the elderly: an experimental study	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-06	Hospital Universitário Gaffree e Guinle - Universidade Federal do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Seniors aged 60 or older; both sexes; registered in the Renascer program; with access to and basic proficiency in the use of Information and Communication Technologies (ICT); with preserved functional and cognitive capacity to moderate cognitive impairment; capable of performing instrumental activities of daily living with a minimum of 2 points on the Telephone item in the Instrumental Activities of Daily Living (IADL) scale; and capable of viewing and responding to text messages and interacting with the group	Elderly individuals with hearing loss or uncompensated visual impairment; a score of 7 or lower on the Instrumental Activities of Daily Living (IADL) scale; with progressive cognitive impairment, such as a medical diagnosis of dementia; for discontinuation criteria, a minimum participation of 50% in activities, both online and by performing activities individually at a time convenient for the participant	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-7bwtfry	Pilates mat exercises and supplementation as strategies to promote health in women 50+	Not yet recruiting	Intervention	2026-04-24	<NULL>	<NULL>	9135	Mat pilates and supplementation as strategy for promoting well-being in women aged 50+: a randomized placebo-controlled clinical trial	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Universidade de Passo Fundo	<NULL>	<NULL>	<NULL>	To participate voluntarily in the study, participants must: understand the study procedures and agree to participate voluntarily and sign the Informed Consent Form; be 50 years of age or older; be menopausal (12 months or more of amenorrhea); be willing to use the new supplementation with annatto (Bixa orellana L), yerba mate (Ilex paraguariensis A. ST.-Hil.) and hops (Humulus lupulus L.) throughout the study; not be using hormone replacement therapy; and have a skin phototype between I and IV on the Fitzpatrick scale (MSD Manuals Professional Edition, [n.d.]), since the equipment used for cutaneous autofluorescence analysis has adequate sensitivity only for these phototypes, ensuring the reliability of the measurements	Uncontrolled systemic arterial hypertension, having had or currently having cancer, autoimmune diseases such as lupus, inflammatory diseases such as Crohn&apos;s disease, no self-reported serious illness, severely ill individuals, and withdrawal of consent; surgery requiring hospitalization within 3 months of the first study visit after screening; absence of health conditions that prevent compliance with study requirements as judged by the investigator based on medical history; severe trauma or surgical event within 3 months of screening; individuals using anticoagulants, since hops have an antiplatelet effect; reluctance or inability to comply with experimental procedures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-7h3wfcg	Impact of Breathing Training on Cardiac Patients&apos; Recovery: Randomized Research Study	Not yet recruiting	Intervention	2026-04-24	<NULL>	<NULL>	9136	Effects of Inspiratory Muscle Strength and Endurance Training on voice and cardiorespiratory function in individuals undergoing Cardiac Surgery: A Randomized Clinical Trial.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-30	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Volunteers aged 40 or older; with a medical prescription for physiotherapy; candidates for valve replacement (VT), coronary artery bypass grafting (CABG), or combined surgery (CABG + VT); clinically stable	Individuals with unstable angina; severe valvular heart disease; head and/or spinal trauma; severe trunk injury; neurological disorders; vocal cord paralysis and laryngeal disorders assessed by an otolaryngologist in the preoperative period; self-reported gastroesophageal reflux (GERD) and/or hearing loss; untreated or exacerbated psychiatric disorders; difficulty responding to questionnaires adequately due to allo- or autopsychological factors; acute kidney injury; peripheral neuropathy; musculoskeletal disease; morbid obesity (Body mass index greater than 40 kg/m²); infectious disease; cancer patients (post-chemotherapy); who have not undergone surgery; who have not had at least five days of preoperative intervention; participants who developed surgical wound infection, stroke and/or myocardial infarction during surgery; worsening of the hospitalization condition	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-88fsw4n	Evaluation of how Laser application may influence recovery after wisdom tooth extraction	Recruiting	Intervention	2026-04-23	<NULL>	<NULL>	9131	Analysis of clinical and blood biochemical parameters as a function of irradiation of modified ILIB in extraction of lower third molars	<NULL>	4, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-15	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Patients in good systemic and local health for the procedures; Patients between 18 and 35 years of age; Both sexes; Indication for extraction of third molars (teeth 38 or 48), with at least two-thirds of the root formed, according to the radiographic evaluation, thus belonging to Pell &amp; Gregory classification I or II and position A or B (Pell GJ &amp; Gregory GT, 1933)	Patients with mandibular third molars in positions 3 and C according to the Pell &amp; Gregory classification; Presence of any local manifestations in the area of ​​interest that may contraindicate the surgical procedure, such as: pericoronitis, odontogenic cysts and tumors associated or not with the third molar, trauma in the region, or any symptoms that indicate the presence of infection; Patients who smoke or have any type of systemic disease (of any organ system), such as diabetes, systemic arterial hypertension, hyperthyroidism, osteoporosis, or gastrointestinal diseases that compromise the outcome of the surgery; Patients who are intolerant to other materials that will be used in the research, such as 2% chlorhexidine alcohol solution, 0.12% chlorhexidine digluconate solution, and 2% mepivacaine hydrochloride solution with 1:100,000 epinephrine;  Female patients who are menstruating, pregnant, or breastfeeding during the surgical procedure; Patients with abnormal sleep patterns, who slept less than 5 hours the night before, or who are taking medications to control psychiatric illnesses, corticosteroids, estrogens, and androgens; Patients who have used anti-inflammatory drugs within 30 days prior to the surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-46j5d25	Study on Pain Education and Multimodal Therapeutic Intervention for Cervical Pain	Recruiting	Intervention	2026-04-23	<NULL>	<NULL>	9132	Evaluation of the Efficacy of Pain Education Associated with Multimodal Therapeutic Intervention in the Management of Cervical Pain: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-12	Fundação Edson Queiroz	<NULL>	<NULL>	<NULL>	Individuals aged between 18 and 59 years; presence of neck pain regardless of symptom duration; both sexes; preserved cognitive function; agreement to participate in the study by signing the Informed Consent Form	History of trauma and/or surgery in the cervical region; neurological disorders; cancer; neuromuscular diseases; receipt of continuous physiotherapy treatment within the last three months; attendance lower than 75% of the proposed sessions, with attendance monitored at each session and participants not meeting this minimum considered as loss to follow-up and excluded from the analysis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-89495pk	Effect of anti-inflammatory injection on the success of anesthesia in lower molar teeth in cases of toothache	Not yet recruiting	Intervention	2026-04-22	<NULL>	<NULL>	9125	Efficacy of submucosal Dexamethasone infiltration in anesthetic success in inferior alveolar nerve block, in cases of Symptomatic Irreversible Pulpitis in mandibular molars: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-10	Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Individuals over 18 years of age of both sexes diagnosed with symptomatic irreversible pulpitis in the first or second mandibular molars; reporting moderate to intense pain at the time of initial assessment; with a score of 4 or higher on the Numerical Pain Scale (NPS); classified as healthy and immunocompetent according to the criteria of the American Society of Anesthesiologists (ASA); adapted for the dental clinic; who demonstrate full comprehension of the pain assessment scales and the informed consent form	Patients who after the start of the procedure decide or need to abandon treatment before the completion of the dental procedure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-3kdnvsg	Management of breastfeeding in the incidence of hospitalization for hyperbilirubinemia in newborns.	Not yet recruiting	Intervention	2026-04-22	<NULL>	<NULL>	9126	Effectiveness of breastfeeding management on weight gain and bilirubin levels in newborns: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal do Piauí	<NULL>	<NULL>	<NULL>	Newborns of both sexes; aged between 24 and 48 hours of life; with gestational age between 37 weeks and 41 weeks and 6 days; and birth weight between 2,500 g and 3,999 g.	Newborns with congenital malformations perceptible on physical examination or reported by the mother; jaundice in the first 24 hours of life; ABO and/or Rh incompatibility; family history of a sibling treated with phototherapy for neonatal jaundice; Asian descent; or the presence of cephalohematoma or ecchymoses, since these conditions constitute risk factors for significant hyperbilirubinemia in neonates with a gestational age greater than 35 weeks.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-6vhp5fq	Acute effect of breaking up sitting time on selective attention and memory: randomized crossover clinical trial	Recruitment completed	Intervention	2026-04-22	<NULL>	<NULL>	9127	Acute effects of interruptions in sitting time on cardiovascular parameters, muscle activity, and cognition in healthy adults	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-10	Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Healthy adults aged 18 to 59 years; regularly enrolled as university students; without diagnosis of chronic diseases; without continuous use of medications or any ergogenic aids; and without injuries or conditions that could prevent prolonged sitting or walking.	Failure to complete any stage of the study including screening assessments baseline evaluations or any of the experimental sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-8n3xjfs	Pharmaceutical care via telemedicine for patients with Chronic Obstructive Pulmonary disease or Asthma	Recruiting	Intervention	2026-04-22	<NULL>	<NULL>	9128	Pharmaceutical care for patients with Chronic Obstructive Pulmonary disease or Asthma	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal de Alfenas	<NULL>	<NULL>	<NULL>	Individuals over 18 years of age with a diagnosis of Chronic Obstructive Pulmonary Disease (COPD) or asthma, regardless of the presence of comorbidities, were included	Patients under 18 years of age or those with cognitive difficulties that interfere with understanding the questions were excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-2g8tk6t	Effects of resveratrol on heart health after exercise in menopausal women	Not yet recruiting	Intervention	2026-04-22	<NULL>	<NULL>	9129	Effects of resveratrol supplementation on cardiovascular Recovery and post-exercise muscle function in menopausal women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Fundaçao Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Women aged 40 to 60 years with body index mass of 18.5 to 34.9 kilograms per square meter and low density lipoprotein high or equal to 130 milligrams per deciliter will participate in the study; All participants must be postmenopausal at the start of the intervention; Age at menopause will be categorized as under 45 years early menopause 45 to 49 years relatively early menopause 50 to 51 years reference or 51 years or older relatively late menopause; They must have had no menses in the last year; Able to comply with the study protocols; They must not have any pathologies that could affect their nutritional status; During participation in this clinical trial all women will receive special attention to ensure their well-being comfort and safety; The study was ethically designed to minimize any physical risks associated with the data collection steps	Self-reported use of anticoagulant agents including nonsteroidal anti-inflammatory drugs oral cortisone or other immunosuppressive agents; Presence of neoplasia or immunological disease; Restricted or reduced physical activity due to chronic health conditions; Blood pressure high or equal to 140/90 millimeters of mercury; Kidney or liver disease; Heart disease including cardiovascular events or stroke; Cancer diagnosis in the last five years; Inability to comply with study requirements and procedures; Inability to perform treadmill test due to limitations such as orthopedic problems or moderate to severe aortic stenosis; History of myocardial infarction in the last three months or angina under treatment; Inability to perform handgrip test due to limitations such as pain or deformity	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-3yryp6x	Shoulder Flexibility and Breast Augmentation Surgery: Randomized Study	Recruitment completed	Intervention	2026-04-22	<NULL>	<NULL>	9130	Shoulder range of motion and breast augmentation: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-05	Universidade Federal de Goiás	<NULL>	<NULL>	<NULL>	Women aged 18 to 60 years; surgical indication for breast augmentation associated with breast ptosis correction	Current or previous breast cancer diagnosis; diabetes mellitus; hypothyroidism; history of previous breast surgeries; including prior mammoplasties of any nature	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-10p7b8qx	Effects of Yoga techniques on the functioning of the heart and brain in older adults	Recruitment completed	Intervention	2026-04-21	<NULL>	<NULL>	9124	Effects of Yoga techniques on autonomic regulation and executive functions in independent older adults	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Centro de Educação Física e Desportos da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Age greater than or equal to 60 years; both sexes; independent and without recent yoga practice; physically active according to the international physical activity questionnaire; preserved cognitive function as assessed by the mini-mental state examination; absence of severe diseases or uncontrolled psychiatric disorders; signed informed consent form	younger than 60 years; dependent in activities of daily living; with recent yoga practice; physically inactive according to the international physical activity questionnaire; with impaired cognitive function as assessed by the mini-mental state examination; with severe diseases or uncontrolled psychiatric disorders; absence of a signed informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-9py9sc7	Effect of virtual reality and walking assistance in gait rehabilitation in Parkinson&apos;s patients	Not yet recruiting	Intervention	2026-04-20	<NULL>	<NULL>	9121	Impact of virtual reality and and partial body weight support  on gait rehabilitation in patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	The inclusion criteria will include participants of both sexes, with functional walking deficits; but who are able to walk without an assistive device for at least 10 meters;  weigh more than 30 kg; are able to respond to and understand commands; are in stages 1–3 of the Hoehn &amp; Yahr scale; have medical supervision; and are available for the duration required by the study	Exclusion criteria will include patients with significant cognitive impairment; severe motor impairments such as disabling dyskinesias; extreme rigidity; or severe postural instability; as well as those who require the continuous use of walking aids. In addition, individuals with acute systemic or neurological comorbidities; severe joint deformities; uncontrolled epilepsy; sensitivity to visual stimulation, or uncorrected visual and vestibular impairments that hinder the safe execution of the protocol will not be included	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-9k25ctr	Use of light and turmeric for the treatment of inflammation and mouth sores in cancer patients	Recruiting	Intervention	2026-04-20	<NULL>	<NULL>	9122	Clinical study in cancer patients on the effectiveness of curcumin-mediated photodynamic therapy (APDT) and low-level laser therapy (photobiomodulation) as an adjunct in the treatment of oral mucositis	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-07-14	Instituto Multidisciplinar em Saúde-Campus Anísio Teixeira - Universidade Federal da Bahia	<NULL>	<NULL>	<NULL>	Patients of both sexes and genders aged 18 years or older; patients with stable lesions undergoing chemotherapy and/or radiotherapy; consent to participate in the research through signing the informed consent form	Patients receiving systemic medication for the treatment and prevention of mucositis; patients unable to comply with the treatment procedure or with the oral hygiene protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-9px8h63	Acupuncture for breast cancer pain: study with women	Not yet recruiting	Intervention	2026-04-20	<NULL>	<NULL>	9123	Effects of Auricular Acupuncture on the treatment of cancer pain in women with Breast Cancer: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; be a woman; be undergoing treatment for breast cancer, regardless of the type of oncological therapy; have undergone surgery for the disease prior to the study, at least three months and at most 10 years earlier; report pain that began after surgery, with an intensity greater than or equal to 4 points on the Numeric Rating Scale (NRS)	Present metastasis; have cognitive impairment that precludes responding to the study instruments; be using high doses of anticoagulants; have undergone auricular acupuncture treatment for cancer-related pain within the three months prior to the study; present ear piercings near the auricular points to be used in the study; report a history of allergy to needles, seeds, or microporous tape; present lesions, inflammation, deformity, or tattoos on the ear; or use a hearing aid	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-6bc29xw	Effects of combined physical training on the response to chemotherapy in patients with metastatic colorectal cancer	Recruiting	Intervention	2026-04-19	<NULL>	<NULL>	9118	Effects of combined physical training on the response to Chemotherapy in patients with Metastatic colorectal cancer: responses of the Autonomic nervous system	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients aged over 18 years old; both sexes;recent diagnosis of colorectal cancer at any stage (new cases) for Crosssectional I and II, and for the longitudinal study, patients with metastatic colorectal cancer with measurable lesions and available and verified biopsy;candidates for chemotherapy sessions (Crosssectional II and Longitudinal);undergoing the first cycle of chemotherapy (Cross-sectional II);performance Status Scale (ECOG- Eastern Cooperative Oncology Group) between 0 and 2;no dementia (score less than 23 on the Mini-Mental State Examination);not having participated in a physical training program in the last 6 months (Longitudinal);no active infections at the time of inclusion in the studies	Patients with uncontrolled comorbidities;patients with cognitive or mental limitations: they may have difficulty understanding and adhering to treatment, requiring additional support;patients with a history of substance abuse: substance use can complicate pain management and symptom control, as well as affect adherence to treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-10v96bt3	Clinical aspects related to shoulder pain	Recruitment completed	Observational	2026-04-19	<NULL>	<NULL>	9119	Understanding biopsychosocial aspects related to pain mechanism-based phenotypes of shoulder pain	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-10	Fundação de Amparo à Pesquisa do Estado de São Paulo	<NULL>	<NULL>	<NULL>	Individuals from both sexes, aged from 18 to 60 years old who report rotator cuff-related shoulder pain in the anterior, lateral or posterior region during arm movement, for more than 4 weeks and intensity of at least 3/10 on the Numerical Pain Rating Scale (NPRS) will be recruited.	Individuals with shoulder pain associated with any of the following conditions will not included: history of recurring shoulder dislocation, adhesive capsulitis (loss of 50% of passive range of motion in any direction), surgery or recent fracture (less than one year) in the upper quarter of the body, inflammatory diseases (rheumatics, infections, or related to neural, vascular or neurological causes), neurological or psychiatric diseases, history of cancer, pregnancy, cognitive deficit, physical therapy treatment or corticoid injection in the previous 6 months or any diagnose of central sensitization syndrome. Exclusion criteria will be non-attendance at the full evaluation process and incapacity to understand the questionnaires or complete all the tests.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-53kxb7j	Using light to treat tooth stains: controlled and randomized trial	Not yet recruiting	Intervention	2026-04-19	<NULL>	<NULL>	9120	Transillumination prior to resin infiltration for masking hypomineralized lesions: a randomized controlled clinical trial	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade Federal do Piauí	<NULL>	<NULL>	<NULL>	Children and adolescents exhibiting well defined; creamy-white or yellow opacities in an incisor without post eruptive structural loss	Participants were those using fixed orthodontic appliances on their incisors; incisors with composite resin restorations; carious lesions on their central incisors; other enamel developmental defects such as dental fluorosis; hypoplasia, amelogenesis and dentinogenesis imperfecta, and participants with non cooperative behavior	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-9vs4zyr	Alternative Therapies in Speech Therapy: how they assist in speech and writing	Recruitment completed	Intervention	2026-04-18	<NULL>	<NULL>	9117	Integrative and Complementary Practices in Speech Therapy: application in the area of oral and written language	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-09	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Children with developmental stuttering aged from 3 years to 11 years and 11 months adolescents aged from 12 years to 17 years and 11 months and adults aged 18 years and older of both sexes presenting stuttering with or without a familial component. Phonological disorder children aged from 4 to 8 years of both sexes. Oral language disorder children aged from 2 to 6 years presenting delay in oral language development. Written language disorder children in the early stages of literacy corresponding to first to fifth grade with ages ranging from 5 to 12 years	Cases with evident neurological alterations; hearing loss; associated syndromes and severe mental disorders, such as psychosis and autism, will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-3x4nbvh	Sensory integration in Virtual Reality for children with Autism	Not yet recruiting	Intervention	2026-04-17	<NULL>	<NULL>	9115	Sensory integration in Immersive Virtual Reality: randomized clinical trial with children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2027-04-01	Universidade Federal de Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Be between 8 and 12 years of age; have prior experience with computer games; have a diagnosis of Autism Spectrum Disorder confirmed by presentation of the Identification Card for Persons with Autism Spectrum Disorder; demonstrate verbal communication skills or communication through Augmentative and Alternative Communication; present sensory difficulties as indicated by the Sensory Processing Measure; demonstrate the ability to complete at least 9 items of the Evaluation in Ayres Sensory Integration	Have a diagnosis of other neurological disorders such as cerebral palsy or Down syndrome; present comorbidities that preclude participation in Immersive Virtual Reality as reported by caregivers; present sensory deficits that prevent the use of Immersive Virtual Reality equipment; report malaise, nausea, or recurrent episodes of vomiting	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-6zppq5h	Use of local anesthetics as a strategy to reduce cough, respiratory complications, and blood pressure changes during tracheal tube removal after general anesthesia	Recruiting	Intervention	2026-04-17	<NULL>	<NULL>	9116	Effects of intracuff Lidocaine and periglottic Ropivacaine, alone or in combination, on Extubation quality, airway morbidity, and hemodynamic stability during elective general anesthesia: A randomized controlled trial	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-10	Departamento de Anestesiologia do Hospital das Clínicas da Faculdade de Medicina de Botucatu (HCFMB) Unesp	<NULL>	<NULL>	<NULL>	Age ≥18 years; both sexes; ASA Physical Status Classification System I–III; elective ophthalmologic surgery under general anesthesia with orotracheal intubation; signed informed consent	Allergy to local anesthetics; Acute respiratory illness; Predicted or completed difficult intubation; Previous tracheostomy; Severe gastroesophageal reflux; Inability to understand assessment scales; Participant refusal	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-7bwk89s	Effects of supervised physical exercise on functional capacity and quality of life of patients with Fontan-type circulation	Not yet recruiting	Intervention	2026-04-16	<NULL>	<NULL>	9106	Effects of supervised cardiopulmonary rehabilitation on the functional capacity of pacientes with Fontan-type circulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Instituto Dante Pazzanese de Cardiologia	<NULL>	<NULL>	<NULL>	Age equal to or greater than 8 years; having undergone Fontan surgery at least 6 months ago; clinically stable, with the ability to perform physical exercises and functional tests	Formal contraindication to physical exercise or cardiopulmonary testing; diagnosis of severe arrhythmias, decompensated heart failure, severe lung diseases, significant motor limitations, or resting peripheral oxygen saturation below 80%	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-7gr7655	How Injectable Platelet-Rich Fibrin can help in Shoulder Osteoarthritis: a clinical study	Recruiting	Intervention	2026-04-16	<NULL>	<NULL>	9107	The role of injectable Platelet-Rich Fibrin in the management of Glenohumeral Osteoarthritis: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Hospital Universitário Pedro Ernesto	<NULL>	<NULL>	<NULL>	Patients aged 50 years or older; symptomatic glenohumeral osteoarthritis refractory to adequate conservative treatment; candidates for shoulder arthroplasty and awaiting surgery, or patients without adequate clinical conditions for surgery because of high surgical risk	Refusal or inability to sign the informed consent form; psychiatric or cognitive disorder impairing evaluation or follow-up; coagulopathy or international normalized ratio greater than 1.5; malignant neoplasm within the previous 5 years; use of orthobiologic treatment in the same joint within the previous 6 months; stroke or acute myocardial infarction within the previous 3 months; local anesthetic intolerance or allergy; participation in another study within the previous 30 days	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-8s6zgk6	Can an injection with bone marrow material help shoulder arthritis?	Recruiting	Intervention	2026-04-16	<NULL>	<NULL>	9108	Do Patients with Glenohumeral Arthropathy undergoing Bone Marrow Aspirate injection experience clinical and functional improvement? A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Patients of both genders; aged over 50 years; with symptomatic glenohumeral osteoarthritis that has not improved with appropriate conventional conservative treatment and with an indication for shoulder arthroplasty; with glenohumeral osteoarthritis grades 1 to 5 according to the Hamada classification.	Failure to sign the Informed Consent Form; psychiatric and/or cognitive disorders that preclude assessment and follow-up; coagulopathies; malignant neoplasm within the last five years; orthobiologic procedures in the same joint within the past 6 months; stroke or acute myocardial infarction within the last 3 months; intolerance or allergy to local anesthetic.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-2r5qwyj	Laser therapy in post-surgery care for head and neck	Recruiting	Intervention	2026-04-16	<NULL>	<NULL>	9109	The role of Photobiomodulation in postoperative care for head and neck surgery	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-15	Irmandade da Santa Casa de Misericórdia de São Paulo	<NULL>	<NULL>	<NULL>	Both genders; age over 18; patients undergoing surgical treatment for squamous cell carcinoma of the upper aerodigestive tract	Salvage surgery; previous radiotherapy or chemotherapy; palliative surgery; diagnostic surgical procedure; surgical procedure to correct complications; Eastern Cooperative Oncology Group (ECOG) 3 or 4; Body Mass Index (BMI) less than 18; and any other surgical procedure that does not have an oncological curative purpose	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-649gzcs	Different types of approaches focused on the well-being of patients with knee osteoarthritis	Recruitment completed	Intervention	2026-04-16	<NULL>	<NULL>	9110	Biopsychosocial Approach strategie in Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-04-01	Universidade São Francisco	<NULL>	<NULL>	<NULL>	Participants must be between 35 and 75 years old; of either sex; have osteoarthritis of the knee joint (unilateral or bilateral) lasting at least 2 years to ensure the chronic nature of the disease; and present pain greater than 4 on the Numerical Pain Scale in 3 of the following actions: climbing and descending stairs; kneeling, sitting and standing; running; and standing for 2 minutes	Participants will not be included in the study if they present any type of contraindication to exercise; severe cardiorespiratory disease; untreated hypertension; uncontrolled diabetes mellitus; motor or sensory neurological deficits; frequent physical activity; fibromyalgia; rheumatoid arthritis; require a walking aid; recent hyaluronic acid injection and/or any type of invasive therapy; or refuse to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-48y88jj	Eye Irritation Treatment with Intense Pulsed Light in Individuals with Glaucoma	Recruiting	Intervention	2026-04-16	<NULL>	<NULL>	9111	Evaluation of Intense Pulsed Light Therapy for Ocular Surface Disease in patients with Glaucoma	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-23	Hospital de Clínicas da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Patients over 18 years of age; volunteers from the Glaucoma sector of the Department of Ophthalmology at the State University of Campinas; diagnosis of Glaucoma in at least one eye; at least 6 months of use of two or more topical hypotensive medications; written provision of informed consent to participate in the study	Patients with any other ocular surface disease, such as Sjögren’s Syndrome, or who have undergone refractive surgery; acute ocular diseases that affect the ocular surface, such as acute conjunctivitis; previous ophthalmologic trauma; previous ophthalmologic surgeries, except cataract surgery; use of contact lenses; patient refusal or failure to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-6hzt9g8	Evaluation of the effects of a superficial and deep energy therapy protocol combined with physical exercise in Individuals with Chronic Low Back Pain: a randomized clinical trial	Recruiting	Intervention	2026-04-16	<NULL>	<NULL>	9112	Evaluation of the effects of a Tecarterapia protocol associated with physical exercise in subjects with Chronic low back pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Brasil	<NULL>	<NULL>	<NULL>	Subjects of both sexes; aged between 30 and 60 years; persistent low back pain of unknown origin for at least 3 months or more without irradiation to lower limbs; pain intensity on movement in the last 7 days with values between 3 and 6 on the Numerical Pain Scale (NPS); no limitation of movements for performing the proposed exercises; body mass index between normal and overweight; availability to participate in evaluations and treatments; with preserved thermal sensitivity; not undergoing other treatment for Chronic Low Back Pain (CLBP)	Medical restriction for performing the proposed treatment; has undergone unconventional or alternative treatments that could potentially have effects on the study results in the last 3 months; subjects who have neurological diseases, fractures, tumors, infections, are pregnant, or have a current use of a pacemaker or other implantable electronic devices	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-8c2rwf3	The effect of sutureless stabilization devices on the prevention of mechanical complications associated with Peripherally Inserted Central Catheters (PICC) in patients hospitalized in the Intensive Care Unit: a pilot study	Recruitment completed	Intervention	2026-04-16	<NULL>	<NULL>	9113	Preliminary feasibility and effectiveness of different sutureless stabilization methods for Peripherally Inserted Central Catheters (PICC) in the prevention of mechanical complications in critically ill adult patients: randomized controlled pilot study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; both sexes; clinical indication for scheduled insertion of a Peripherally Inserted Central Catheter in the upper limbs, either at admission or during the Intensive Care Unit stay; and adequate venous diameter to safely accommodate a 4 or 5 French catheter	Patiens with chronic kidney disease, to preserve the venous network in patients with potential future need for renal replacement therapy via arteriovenous fistula; patients with clinical conditions compromising the integrity of the skin or subcutaneous tissue in the selected limb, including extensive, infectious, or adjacent scar lesions (for example: second-degree or higher burns, active skin infections, extensive scars); catheter insertion feasible only in the antecubital fossa or forearm veins, as these sites are not recommended as preferred sites for peripherally inserted central catheter insertion according to current international guidelines; known history of hypersensitivity or allergy to any of the materials or devices used in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-688ffs9	Quality of life and oral health of individuals with traditional dentures and improved chewing function	Other	Intervention	2026-04-16	<NULL>	<NULL>	9114	Satisfaction, quality of life and oral health of complete denture wearers, associated with the masticatory function with interchangeable occlusal schemes	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-16	Universidade Estadual Paulista Júlio de Mesquita Filho	<NULL>	<NULL>	<NULL>	Participants of both sexes. Aged 45 years or older. Complete denture wearers with a need for replacement based on patient desire or clinical judgment, such as inadequate intermaxillary relationships and/or severe wear of artificial teeth. Individuals willing to participate in the research and receive the proposed treatment. Good comprehension of spoken Portuguese. Mandibular ridges classified as resorbed according to the methods described by Marcello-Machado et al. and Cawood and Howell. Normal unstimulated salivary flow rate between 0.3 and 0.4 mL/min. Edentulism time of at least 1 year prior to denture replacement	Debilitating systemic changes. Signs/symptoms of temporomandibular disorders. Refusal to provide informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-10v32pjc	The  effect of exercise and Physcial Therapy on heart rate in people with Spinal Cord Injury: a randomized clinical trials	Not yet recruiting	Intervention	2026-04-15	<NULL>	<NULL>	9102	Heart rate variability patterns in individuals with Spinal Cord Injury undergoing a physical exerecise program and Physical Therapy:  randomized clínical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-15	Departamento de Fisioterapia da Universidade Estadual de Londrina	<NULL>	<NULL>	<NULL>	Volunteers of both sexes; aged 18 to 50 years; with a medical diagnosis of spinal cord injury with neurological levels ranging from the second thoracic segment to the first lumbar segment; with spinal cord injuries classified as complete like paraplegia and anesthesia and incomplete  like paraplegia and hypoesthesia; with an injury dating back more than 6 months; who do not regularly engage in physical activity or physical therapy	Individuals with other associated neurological diseases like the traumatic brain injury and peripheral nerve injury; heart disease; lung disease, suspected LME; and those who are unable to complete the tests for any reason including withdrawal, hospitalization, infections, and skin, osteoarticular, vascular, or respiratory complications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-2n84wsc	Effect of beetroot juice on the performance of women who practice cycling	Not yet recruiting	Intervention	2026-04-15	<NULL>	<NULL>	9103	Effects of beetroot juice concentrate supplementation on the performance of female cyclists in an endurance trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-27	Departamento de Ciências do Movimento Humano da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women aged between 18 and 60 years; cycling practitioners with a minimum of one year experience; training frequency of at least two to three times per week; signing of the Informed Consent Form	Presence of intellectual or physical disabilities; clinical, neuromotor, neurological, psychiatric or cognitive impairments; recent injury or in recovery period; musculoskeletal injuries; use of androgenic anabolic steroids; smoking; patients with known chronic degenerative pathologies	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-79d5xqg	".
Effect of bergamot orange oil on elderly sleep quality"	Recruiting	Intervention	2026-04-15	<NULL>	<NULL>	9104	Effect of Aromatherapy with Citrus Bergamia essential oil on the sleep quality of elderly people: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Alfenas-MG	<NULL>	<NULL>	<NULL>	Individuals of both sexes, aged over 60, including current and retired employees of the Federal University of Alfenas; and the general public; who have sleep disturbances as indicated by a Pittsburgh Sleep Quality Index (PSQI) score of ≥5	Using other integrative practices to improve sleep quality; having an allergy or intolerance to strong odors;having skin irritation or lesions on the face; having a known history of respiratory disorders, such as asthma	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-7sstr78	Effects of Non-Invasive Brain Stimulation Associated with Voice Therapy in Participants with Voice Disorders: A randomized clinical study	Recruiting	Intervention	2026-04-15	<NULL>	<NULL>	9105	Effect of Transcranial Direct Current Stimulation associated with Voice Therapy for Behavioral Dysphonia: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-22	Universidade Federal de Pernambuco - UFPE	<NULL>	<NULL>	<NULL>	The inclusion criteria for participation in the study are: being an adult aged between 18 and 59 years; having behavioral dysphonia without lesions; diagnosis confirmed by an otorhinolaryngologist; participants will be required to provide a medical report issued by the otorhinolaryngologist	The exclusion criteria are: volunteers with pacemakers; metallic implants in the head or cervical region; use of neuroactive medication; history of seizures; individuals undergoing speech therapy during the data collection period; and individuals with dysphonia of neurological etiology or caused by recurrent laryngopharyngeal reflux	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-4djzt48	Impact of different physical activities on the health of women in the climacteric	Not yet recruiting	Intervention	2026-04-14	<NULL>	<NULL>	9097	Impact of different types of non-pharmacological interventions on the health of climacteric women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Centro Universitário UNIFIPMOC	<NULL>	<NULL>	<NULL>	Women in the climacteric stage aged between 45 and 70 years; receiving care from primary health care services in Montes Claros, Minas Gerais, Brazil; medically cleared to participate in physical activity through a medical certificate.	Physical or cognitive limitations that prevent participation in the proposed interventions; uncontrolled cardiovascular, respiratory, or musculoskeletal diseases that preclude exercise practice; participation in another structured physical exercise program during the study period; failure to complete baseline assessments.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-9q5kr7m	Use of an Anti-Inflammatory Drug (Indomethacin) to Prevent Pancreatic Inflammation after an Endoscopic Procedure (ERCP)	Recruiting	Intervention	2026-04-14	<NULL>	<NULL>	9098	Indomethacin in the Prevention of Post-ERCP Pancreatitis in a Low Risk Population: Placebo-Controlled Study	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-09	Julio Carlos Pereira Lima	<NULL>	<NULL>	<NULL>	Patients over 18 years of age, who are referred to the Neuroradiology Service of Hospital São José do Complexo Santa Casa de Misericórdia de Porto Alegre to undergo ERCP, who, after due explanations about the study, accept to participate and sign the informed consent form.	Allergy to indomethacin, previous digestive bleeding or history of peptic ulcer disease, chronic renal failure, bile duct prosthesis or previous papillotomy.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-2ttqd58	Evaluating Knee Function and Recovery in Patients After Anterior Cruciate LigamentL Reconstruction	Data analysis completed	Intervention	2026-04-14	<NULL>	<NULL>	9099	Functional Analysis of Patients Undergoing Anterior Cruciate Ligament Reconstruction	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Juiz de Fora	<NULL>	<NULL>	<NULL>	Age between 16 and 40 years; both sexes; patients from the Knee Surgery outpatient clinic at Hospital Universitário da Universidade Federal de Juiz de Fora; indication for elective knee surgeries (ligament or meniscal repair).	Presence of concomitant pathologies (previous muscle alterations, morbid obesity, or autoimmune diseases); cardiovascular or metabolic diseases; smoking; use of illicit drugs or anabolic steroids; use of supplements that accelerate metabolism or affect vascular dilation; indication for total or partial knee arthroplasty.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-3thd342	Influence of school Physical Activity on Health, body conditioning, and Medication use among adolescents in Guarapuava	Recruiting	Observational	2026-04-14	<NULL>	<NULL>	9100	Specialized Sports Training Program (AETE): Impact on functionality, health, and medication use in adolescents from the state public school system of Guarapuava-PR	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-09	Universidade Estadual do Centro-Oeste	<NULL>	<NULL>	<NULL>	Adolescents aged between 11 and 17 years. Being regularly enrolled in one state public schools in Guarapuava-PR. For the exposed group: being a member of the AETE sports training program in any of the offered modalities (futsal, basketball, volleyball, handball, track and field, or table tennis). For the control group: being a regular student at the same educational institution but not participating in the AETE program	Youth enrolled in the AETE program for less than 60 days. Pregnant adolescents. Students who decline to participate in the study or whose guardians do not authorize their participation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-5sjyj2n	The influence of fasting on the performance of overweight people.	Recruitment completed	Intervention	2026-04-14	<NULL>	<NULL>	9101	Investigation of the possible influence of a 16-hour fast on the strength performance of overweight individuals.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-01	Escola de Educação Física da Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	As inclusion criteria participants must be overweight and enroll in the gym with the objective of weight loss and be classified as untrained that is individuals without previous history of resistance training or who have not practiced it for at least twelve uninterrupted months	As exclusion criteria all volunteers who present injuries capable of interfering with performance during the experiment will be removed from the sample pregnant women breastfeeding women women attempting to become pregnant individuals with a history or diagnosis of eating disorders as well as those who present previous injuries that prevent the practice of physical exercise will not be accepted in the study participants following a structured diet plan those using medications or ergogenic aids that may influence muscle strength such as testosterone and growth hormone individuals with comorbidities that may compromise data collection individuals with pacemakers and diabetic individuals using hypoglycemic medications will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-102gfznr	Study on the use of personalized molds versus traditional technique for the correction of skull defects	Recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9087	Comparison between in situ molded versus prototyped cranioplasty: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Faculdade de Medicina de Botucatu/UNESP	<NULL>	<NULL>	<NULL>	adult patients, both gender, above 18 years old, with cranial bone defects; cranial defect size between 50 cm² and 150 cm²; adequate clinical condition for elective surgery	patients with active infection; history of rejection to biomaterials; patients with immunosuppression	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-3x9ypky	Study on the gradual introduction of baked milk foods for the treatment of cow’s milk allergy.	Recruitment completed	Intervention	2026-04-13	<NULL>	<NULL>	9088	Stepwise Introduction Protocol of Extensively Heat-Processed Milk in the Treatment of IgE-Mediated Cow’s Milk Allergy	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2019-02-10	Hospital das Clínicas da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	A convincing clinical history of IgE-mediated cow’s milk allergy; positive cow’s-milk–specific IgE (&gt;0.1 kU/L) in the most recent test (collected up to 12 months prior to the date of inclusion) and/or a positive skin prick test (&gt;3mm); casein-specific IgE ≤50 kU/L in the most recent test, collected within up to 12 months prior to the date of inclusion; evidence of ongoing clinical allergy. The criteria used to define ongoing allergy was the last allergic reaction reported by the patient during the clinical history as follow: less than 1 year for patients aged ≤4 years and  less than 2 years for patients aged ≥5 years; any gender was included; minimal age 2 years old	Uncontrolled allergic comorbidities such as moderate to severe atopic dermatitis, asthma, and rhinitis; negative cow’s-milk–specific IgE or immediate-reading skin prick test (≤0.1 kU/L or ≤3 mm, respectively), regardless of a clinical history suggestive of allergy; a clinical history of allergic reactions to baked milk within the past 6 months; serum casein levels ≥51 kU/L; regular consumption of baked milk prior to initiation of the protocol; a confirmed diagnosis of eosinophilic esophagitis; pregnancy; mental or cognitive impairment that precludes understanding of the procedure and assessment of risks, as well as difficulty in promptly recognizing allergic reactions and implementing emergency measures.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-7y2ck4f	Use of sonodynamic therapy for the treatment of medication-related osteonecrosis of the jaw	Recruitment completed	Intervention	2026-04-13	<NULL>	<NULL>	9089	Effects of Sonodynamic Therapy (SDT) in Patients with Medication-Related Osteonecrosis: A preliminary study.	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-01	Instituto e Centro de Pesquisas São Leopoldo Mandic	<NULL>	<NULL>	<NULL>	patients aged 18 years or older; diagnosis of medication-related osteonecrosis of the jaw (mronj) according to ruggiero criteria; history of exposure to bone-modifying agents; presence of exposed necrotic bone; ability to understand and comply with the treatment protocol	history of head and neck radiotherapy; presence of active malignant disease in the oral cavity; inability to perform oral hygiene; known allergy to methylene blue	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-5643qq3	Effect of Laser Acupuncture in children with Autism	Recruitment completed	Intervention	2026-04-13	<NULL>	<NULL>	9090	Effectiveness of Laser Acupuncture in children diagnosed with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Programa de Pós-Graduação em Odontologia da Universidade Federal do Paraná	<NULL>	<NULL>	<NULL>	Male and female children; aged between five and twelve years; previously diagnosed with Autism Spectrum Disorder (ASD) and evaluated by a neurologist; who regularly attend the multidisciplinary institution in which they are officially enrolled	Children with syndromic conditions, those with contraindications to laser acupuncture (such as undergoing cancer treatment; uncontrolled epilepsy; active infections; fever; wounds; or the presence of dermatitis at the acupuncture points); or those who refuse to participate in the study will be excluded from the main trial	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-88q3q9j	Temporary implants for restoring lost teeth in children and adolescents after accidents	Not yet recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9091	Temporary Implants in Anterior Rehabilitation of Children and Adolescents with Traumatic Tooth Loss	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Faculdade de Odontologia - Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients in the growth phase aged between 6 and 17 years; traumatized permanent anterior dentition; single anterior edentulism resulting from tooth avulsion or root resorption following replantation; absence of the tooth in the dental arch or current indication for provisional rehabilitation in the anterior region; healed soft tissues without clinical signs of acute infection; systemic health condition compatible with the proposed treatment; signed informed consent from the patient and legal guardians when applicable; willingness to comply with the full clinical follow-up protocol	Technical inability to maintain the provisional restoration out of functional occlusion; persistently poor oral hygiene or presence of moderate to severe gingivitis, periodontitis, or active infection at the site; smoking in adolescents; uncontrolled systemic diseases or use of medications that interfere with bone metabolism including chronic systemic corticosteroids, immunosuppressants, or bisphosphonates; refusal or inability to attend scheduled follow-up visits and undergo serial clinical and radiographic assessments over the 24-month period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-67m72sm	Effect of Magnetic Stimulation on Body Movement	Not yet recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9092	Influence of Transcranial Magnetic Stimulation on motor evoked potentials	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-05	Universidade Federal de Alfenas	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 30 and 75 years; diagnosis of left ischemic stroke confirmed by computed tomography or magnetic resonance imaging; between 3 weeks and 1 year post stroke; right upper limb motor preference assessed by the Edinburgh Handedness Inventory translated and validated into Portuguese with inclusion of only right handed participants with right hemiparesis and preserved right handgrip function; minimum score of 27 points in the upper limb domain of the Fugl Meyer scale	Left sided motor preference assessed by the Edinburgh Handedness Inventory; orthopedic disorders; contraindications to repetitive transcranial magnetic stimulation including personal or first degree family history of epilepsy or seizures presence of metallic implants or active electronic devices in the head or neck presence of cardiac pacemaker or implanted defibrillator; inability to understand written and spoken Portuguese; pain during task execution; difficulty performing handgrip or index finger flexion movements; failure to reach at least 70 percent of maximal voluntary isometric contraction	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-323k7by	Evaluation of the healing potential of PolyTissue® dressing in the treatment of burns.	Recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9093	Clinical evaluation of PolyTissue® Film and/or Hydrogel in the treatment of Burns.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Hospital da Restauração	<NULL>	<NULL>	<NULL>	Children, adolescents, and adults, with no age limit; of any gender; diagnosed with first and/or second-degree burns	Participants who do not return for clinical reassessment; who present with clinical complications; who have associated diseases; who have contraindications for the use of dressings; who have very deep burns; who have third-degree burns; burns requiring skin grafting; infected burns	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-8tm8xfp	Evaluation of clinical parameters and patient satisfaction after the Removal of Direct Veneers in Composite Resin	Recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9094	Conservative approach for the Removal of Direct Veneers in Composite Resin: clinical parameters and patient satisfaction	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Positivo	<NULL>	<NULL>	<NULL>	Age between 18 and 50 years; good oral and systemic health conditions; absence of malocclusion; presence of at least one maxillary anterior tooth treated with a direct composite resin veneer; acceptance of the Informed Consent Form	Teeth with rotation and/or crowding; teeth with periodontal problems; teeth with gingival recessions; pregnant and/or lactating women; patients with xerostomia; users of dental prostheses in general; patients with parafunctional habits	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-8zk47ww	Effect of collagen on muscle mass gain and strength in women with lipedema	Not yet recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9095	Effect of supplementation with bioactive collagen peptides on lean mass gain and muscle strength in women with lipedema	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Abralipedema Pro Organização de Ensino Ltda	<NULL>	<NULL>	<NULL>	Women aged greater than or equal to 25 years and less than or equal to 45 years; clinical diagnosis of lipedema stages II to III; regular menstrual cycles or medication-induced amenorrhea; regular physical activity practice greater than or equal to 150 minutes per week; body weight stability with variation less than or equal to 3 percent in the last 3 months; agreement to maintain dietary habits and physical activity level during the study; discontinuation of supplements that may interfere with muscle mass, such as protein supplements, creatine and branched-chain amino acids (BCAA); signing of the Informed Consent Form (ICF).	Pregnant women; breastfeeding women; women planning pregnancy; presence of symptoms or diagnosis of menopause; uncontrolled chronic diseases; relevant musculoskeletal or neuromuscular disorders; fractures within the last 12 months; performance of aesthetic surgeries or liposuction within the last 6 months; recent use of protein supplements or substances that affect body composition; use of medications that significantly interfere with body composition; allergy to supplement components; presence of eating disorders; severe psychiatric disorders; participation in another clinical study within the last 12 months; any condition that prevents adherence to the protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-9vxnhpk	Shockwave Therapy for the treatment of Lipedema	Recruiting	Intervention	2026-04-13	<NULL>	<NULL>	9096	Effect of Shockwave Therapy on Lipedema: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-30	Universidade Federal da Paraíba	<NULL>	<NULL>	<NULL>	Women; with early-stage lipedema (stage I/II) affecting the lower limbs (types 2, 3, and 5); aged over 18 years; presenting pain greater than three (3) on the Numeric Rating Scale (NRS); who have not undergone previous surgery for lipedema; without skin lesions or pacemakers; not using medications for lipedema-related symptoms, such as pain or edema, within 48 hours prior to the intervention; not undergoing other treatments for lipedema; and who agree to participate in the study by signing the Informed Consent Form (ICF)	Presence of a pacemaker; coagulation disorders; use of anticoagulant medications; history of neoplasia; pregnancy; soft tissue wound infection; osteomyelitis; presence of an adverse reaction	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-2v463n3	Study on pain control after surgical approach to gallbladder removal	Recruiting	Intervention	2026-04-11	<NULL>	<NULL>	9086	Ketamine vs Magnesium Sulfate in video cholecystectomy: evaluation of postoperative pain, pilot study	<NULL>	1-2, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-05	Sociedade Portuguesa de Beneficiencia	<NULL>	<NULL>	<NULL>	The inclusion criteria consist of patients aged between 18 and 70 years; both sexes; scheduled for elective laparoscopic cholecystectomy who fall into American Society of Anesthesiologists (ASA) classifications I or II	Exclusion criteria include: allergy to any substance used in the study protocol; renal insufficiency; contraindications to the drugs that are part of the protocol; language, hearing, or other limitations that may impair communication between the participant and the team; refusal to participate in the study; refusal to sign the Informed Consent Form; body mass index (BMI) greater than 35 kg/m²; presence or treatment of chronic pain; use of illicit drugs; cognitive impairments of any origin	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-89n6n8r	The use of Psilocybe cubensis mushroom in the treatment of Tobacco Use Disorder	Recruitment completed	Intervention	2026-04-10	<NULL>	<NULL>	9081	Use of Psilocybe cubensis for the reduction of tobacco consumption	<NULL>	1-2, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-15	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Current diagnosis of Tobacco Use Disorder (APA, 2013); smokes at least 10 cigarettes a day; concerned about the smoking habit and seeking treatment; consents to participate in the research, by agreeing to and signing a Free and Informed Consent Form; agrees to abstain from alcohol or other psychotropic substances, with the exception of tobacco, 24 hours prior to the experimental drug administration sessions; available family members or friends who can pick up and accompany overnight after the experimental drug administration session.	Kidney, liver, heart, neurological or esophageal diseases; blood pressure exceeding 140 mm Hg systolic and 90 mm Hg diastolic; cancer as a result of tobacco consumption; psychiatric symptoms (acute psychosis, suicidal ideation, bipolar disorder or severe symptoms of depression or anxiety); personal history of a clinically significant suicide attempt; family history of schizophrenia, bipolar disorder or suicide; personal history of 10 or more occasions of psychedelic substance use, or some use in the past 30 days; diagnosis of Substance Use Disorder (except tobacco) in the last 48 months; active legal problems with potential result of incarceration; current use of selective serotonin reuptake inhibitors (SSRIs) or monoamine oxidase (MAOIs) inhibitors; current use of naltrexone, disulfiram, acamprosate, methylphenidate, bupropion, varenicline, baclofen; clinical indication for hospitalization; possibility of adverse emotional or behavioral reactions according to clinical assessment (i.e., evidence of personality disorders, severe current stressors, lack of significant social support); possibility of pregnancy or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-549sw73	Colprecardio: Local capacities for the prevention of cardiovascular disease in Colombia	Recruiting	Intervention	2026-04-10	<NULL>	<NULL>	9082	Colprecardio: Strengthening the capacity of municipal health secretariats (MHS) for the prevention of cardiovascular disease (CVD) in Colombia	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-25	Escola de Governo, Universidade dos Andes	<NULL>	<NULL>	<NULL>	The trainers will be professionals from the departmental and municipal health secretariats or their equivalents in the indigenous communities of Cauca Colombia; with training in health or social sciences and at least six months of experience in public health; they must have basic oral and written communication skills; as well as minimal technological skills for using computers; their selection is not random; participants must demonstrate an explicit interest in participating in accordance with a commitment agreement that stipulates the requirements rights and obligations of participation and have the minimum required internet connectivity. In the case of the Local Cardiovascular Disease Prevention Teams (ELPEC); will be comprised of teams of professionals; technicians; and technologists from the municipal health secretariats of Cauca Colombia responsible for developing interventions for the prevention of cardiovascular disease in their territories	Regarding the trainers; inability to guarantee sustained participation during training and associated activities; imminent or confirmed change of duties or position that prevents fulfilling the role of trainer during the implementation period; limitations that prevent the effective use of the tools required for the virtual component; non-acceptance or withdrawal of consent or non-signing of the participation commitment and simultaneous participation in an equivalent training process that may interfere with the attribution of changes evaluated in the study. In the case of the Local Cardiovascular Disease Prevention Teams (ELPEC); withdrawal or lack of institutional political will to participate during the implementation period; lack of real and sustained minimum connectivity to develop the virtual component and monitoring instruments; inability to form or maintain an operational Local Cardiovascular Disease Prevention Teams (ELPEC) during the intervention; security conditions or logistical barriers that prevent the safe and reasonable execution of the planned activities; Inability to provide the minimum information required for measurements and monitoring within the established timeframes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-2jyc55x	Effect of combined Training with Noninvasive Brain Stimulation on physical and motor performance in Athletes, Adults, and Older People with and without Parkinson Disease	Data analysis completed	Intervention	2026-04-10	<NULL>	<NULL>	9083	Effects of Mixed-Mode Training associated with Transcranial Direct Current Stimulation on physical and motor performance in Athletes, Healthy Adults, and Older Adults with and without Parkinson’s Disease	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-11	Universidade Anhembi Morumbi	<NULL>	<NULL>	<NULL>	Healthy adults and Olympic weightlifting athletes; older adults aged 50 years or older; older adults diagnosed with Parkinson’s disease by a specialist physician in a non-advanced stage and in the ON phase of medication; participants of both sexes	Individuals with orthopedic deformities; other neurological diseases; presence of metal in the head, surgical clips or metallic plates; implanted devices such as pacemakers, deep brain stimulation or cochlear implants; need for assistive devices for locomotion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-3z56bpx	Brazilian Fermented Beverage and Sports Performance	Recruitment completed	Intervention	2026-04-10	<NULL>	<NULL>	9084	Kombucha produced with brazilian native fruits: probiotic potential and effects on the performance of futsal athletes	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-20	Programa de Pós-graduação em Ciência de Alimentos da Universidade Estadual de Londrina	<NULL>	<NULL>	<NULL>	Participants of both genders may be selected; age range between 18 and 25 years old; non-smokers; those who have not consumed dietary supplements within one week prior to the start of the trial	Individuals who do not agree to participate in the study; individuals with chronic diseases; individuals who use vitamins; antioxidants; ergogenic agents; foods containing probiotics; patients who use antibiotics; anti-inflammatory drugs; subjects who have been absent from training and competitive activities due to overuse injuries for more than 7 days	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-3vpcw43	Performance of composite resins and 3D resins in molar restorations	Recruiting	Intervention	2026-04-10	<NULL>	<NULL>	9085	3D-printed resin restorations for Class II defects in permanent molars: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-04	Departamento de Odontologia Restauradora da Universidade Federal do Paraná	<NULL>	<NULL>	<NULL>	Individuals over the age of 18; of both sexes; capable of understanding and signing the Informed Consent Form (ICF); with teeth indicated for functional occlusion; with oral conditions compatible with restorative treatment; with at least 2 molars indicated for Class II restoration; with cavities measuring at least 4 mm; with margins of the cavo-superficial angle entirely supragingival; and whose teeth have not undergone prior endodontic treatment	Pregnant women or women who are breastfeeding; individuals with active periodontal disease or oral infection; those with systemic or behavioral factors that may compromise oral health or the success of the restoration, such as active smoking, metabolic diseases, immunosuppression, or use of medications that interfere with healing or dental integrity; those with a known allergy to any component of the resin used; without active orthodontic treatment involving the selected teeth; and who have active clasps from removable partial dentures, intraoral devices, or prostheses that interfere with the selected teeth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-8ny87gr	Effect of Clinical Simulation on Teaching-Learning of Cardiac Arrest in Pregnant Women in Hospital Setting	Recruitment completed	Intervention	2026-04-09	<NULL>	<NULL>	9074	Effect of clinical simulation on teaching and learning of cardiorespiratory arrest in pregnant women in an in-hospital setting: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Nursing students; age 18 or older, enrolled in the Nursing Undergraduate Course and enrolled in the fifth to ninth period	Nursing students who do not complete one of the clinical simulation stages and those with special needs that prevent them from carrying out the proposed clinical simulation strategy will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-5p9x6hb	Integrated care for anxiety and well-being in adults and elderly: mixed methods study with guided spiritual visualization and aromatherapy with lavender essential oil	Not yet recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9075	Integrative nursing in the care of anxiety and well-being of adults and older adults: study of mixed methods with guided imagery of spiritual approach and aromatherapy with Lavandula angustifolia essential oil	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Departamento de Enfermagem	<NULL>	<NULL>	<NULL>	Participants of either sex; age ≥ 19 years; with a history of mild to moderate anxiety whether diagnosed or self-reported; with no history of psychiatric disorders and no allergy to lavender or other scents	Presence of severe anxiety; olfactory disorders or hearing impairments that may prevent the patient from hearing the audio used during the image guided procedure properly	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-8sd4fw4	Can removing proteins before Resin Infiltration improve the appearance of white spots in front teeth affected by MIH? A randomized clinical trial	Recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9076	Influence of Deproteinization as a pre-treatment for Resin Infiltration on the masking of opacities in anterior teeth affected by MIH: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-21	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Individuals aged between 6 and 14 years who present at least one permanent incisor with molar-incisor hypomineralization opacities of white-cream and yellow-brown coloration.	amelogenesis imperfecta; tetracycline staining; hypoplasia; fixed orthodontic appliances; previous restorations; dental caries; opacities restricted only to anterior teeth; teeth with post-eruptive fracture; patients whose parents do not allow participation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-97qwcyb	Effectiveness of artificial materials in preserving bone and improving tooth retention - A comparative clinical study	Recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9077	Efficacy of biphasic synthetic calcium phosphate bone substitutes with different particle sizes in alveolar preservation for implant-supported dental restoration – A randomized, parallel-group clinical trial with a negative control	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-13	Atitus Educação	<NULL>	<NULL>	<NULL>	Individuals aged 17 or older; both gender; capable of giving informed consent by signing an Informed Consent Form; in good general health; with clinical and radiographic indications for tooth extraction and the potential for subsequent implant-supported prosthetic rehabilitation; and using an appropriate method of contraception, when applicable	Individuals with local conditions that compromise surgery or healing; coagulation disorders; advanced periodontal disease; active infection at the surgical site; hypersensitivity to the study materials; systemic diseases that affect healing; use of illicit drugs; recent participation in other clinical trials; or pregnancy or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-10vpw4bv	Physical therapy exercises to improve pain, quality of life, and physical capacity in Cancer patients receiving Palliative Care	Data analysis completed	Intervention	2026-04-09	<NULL>	<NULL>	9078	Analysis of the influence of Physiotherapy Exercise on pain, quality of life, and functional capacity of Cancer patients undergoing Palliative Care	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-01	Fundação Doutor Amaral Carvalho	<NULL>	<NULL>	<NULL>	Patients aged 60 or older with a diagnosis requiring exclusive Palliative Care, meaning those who will no longer receive any invasive or life-prolonging interventions; Patients with intact neurological function who are able to respond to commands and answer requested questionnaires; Patients who score between 1, 2, or 3 on the ECOG scale (where 1 – presents symptoms of the disease but is ambulatory and leads a normal day; 2 – Out of bed more than 50% of the time; and 3 – In bed more than 50% of the time) and score between 30% (Very disabled; requires hospitalization and active supportive treatment) and 70% (Able to care for oneself; unable to carry out normal activities or perform active work) on the Karnofsky Scale (performs transfers to a chair) to 7 (static gait with or without assistance); Patients with a score of 3 (performs transfers to a chair) to 7 (static gait with or without assistance) on the ICU Mobility Scale; Patients with a score on the Visual Analogue Scale. (EVA) from 3 (mild moderate pain) to 7 (intense moderate pain); Patients who report a score of 0 to 7 on the Borg Scale; 8. Patients who remain hospitalized for at least 7 days.	Patients who remain hospitalized for less than 7 days; Patients who develop a need for palliative sedation during the evaluation, intervention, or re-evaluation period; Medical advice for absolute bed rest; Intense ventilatory discomfort that makes it impossible to carry out the exercise program; 5. Death during the 7-day period in which the evaluation and intervention will be carried out.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-328f225	Use of Light Therapy as support for Gum Treatment in patients with Periodontitis	Not yet recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9079	Effect of Photodynamic Therapy as an adjunct to Non-Surgical Periodontal Treatment in patients with Periodontitis randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Facultad de odontología Universidad Central de Venezu	<NULL>	<NULL>	<NULL>	individuals of both sexes; age 18 years or older; diagnosis of stage III or IV periodontitis; no periodontal treatment within the last three months; no antibiotic therapy within the last three months	smoking; presence of uncontrolled systemic diseases; uncontrolled diabetes mellitus; pregnancy or lactation; malignant diseases; oncologic treatment; use of orthodontic appliances; allergy to methylene blue; age over 60 years	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-79zrm8y	Effect of an educational program on antibiotic dispensing quality in community pharmacies: a multicenter study	Not yet recruiting	Intervention	2026-04-09	<NULL>	<NULL>	9080	Impact of an Educational Program on the quality of antimicrobial dispensing in community pharmacies: a multicenter study	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Pharmacists working in private community pharmacy chains; who perform medication dispensing; aged over 21 years; male or female; holding a higher education degree in Pharmacy; and who agree to participate in the study voluntarily	Pharmacists who are unavailable to participate in the educational program; who may compromise the anonymity of the simulated patient; whose data cannot be collected after the intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-34qpqq8	Influence of the time of day and indoor luminosity on the responses of the heart and vessels to the execution of a bou of exercise on the cycle ergometer	Recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9067	Effect of the phase of the day and indoor luminosity on cardiovascular responses assessed during and after an aerobic exercise session	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-10	Univesidade de São Paulo	<NULL>	<NULL>	<NULL>	Males; 18 to 59 years; systolic blood pressure between 120-139 mmHg and diastoic blood pressure between 80-89 mmHg. No further evaluation required for physical exercise	smokers; body mass index greater than 35 kg/m2; diagnose of any chronic disease; regular use of medications that affect the cardiovascular system, vitamin complexes, or dietary supplements; physically active or regular participation in physical training programs; extreme evening or morning chronotypes; cardiovascular abnormalities during exercise	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-3q8th6m	Treatment to reduce tooth sensitivity in children with enamel defects and its impact on quality of life	Recruitment completed	Intervention	2026-04-08	<NULL>	<NULL>	9068	Zero caries municipality: a proposal of oral health for child and adolescent population	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Children and adolescents aged 6 to 16 years; presence of molar incisor hypomineralization; presence of dentin hypersensitivity; parents or guardians who provided informed consent; participants who provided assent	Patients with enamel defects not related to molar incisor hypomineralization; presence of extensive carious lesions in evaluated teeth; recent use of desensitizing agents; systemic conditions that may interfere with dentin hypersensitivity; uncooperative patients	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-6grmm4g	Beach Tennis versus Combined Training on 24-hour Blood Pressure	Recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9069	Effects of recreational beach tennis versus combined training on 24-hour ambulatory blood pressure	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-31	Hospital de Clínicas de Porto Alegre	<NULL>	<NULL>	<NULL>	Men and women; Aged 50 to 80 years; medically diagnosed with hypertension; using up to two antihypertensive medications; willing to participate and sign the informed consent forms; office blood pressure between 130-179 and 80-110 mmHg	Diseases that limit the performance of physical exercises, such as lung disease, valvular heart disease, and renal failure; underlying cardiovascular disease previously diagnosed by a physician, occurring in the last 24 months, such as acute myocardial infarction, angina or stroke, or heart failure; diseases that reduce life expectancy; regular physical activity practitioners (i.e., 3 or more sessions per week of high intensity exercise moderate or vigorous); body mass index greater than 39.9 kg/m²; diabetic proliferative retinopathy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-8rv7d8t	Self-Massage for Pain Relief in Parkinson&apos;s Patients: Initial Study with Cost Analysis	Recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9070	Self-Myofascial Release in the management of musculoskeletal pain in individuals with Parkinson&apos;s Disease: a randomized controlled pilot and feasibility study with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-09	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Individuals with a clinical diagnosis of Parkinson&apos;s disease according to the United Kingdom Parkinson&apos;s Disease Society Brain Bank criteria; on stable antiparkinsonian medication and with persistent nonspecific musculoskeletal pain for more than three months; participants of both sexes; over 18 years of age; preserved cognitive function.	Individuals diagnosed with other neurological or psychiatric diseases that compromise their participation in assessments or interventions will be excluded from the study; those who have undergone therapies that influence pain other than through exercise (such as electrotherapy, TENS, acupuncture, transcutaneous brain stimulation) or medication in the last three months; individuals with recent trauma or surgery associated with chronic musculoskeletal pain; those with pressure sores or wounds that prevent certain positions; those diagnosed with cancer or fracture in the last three months; those with pain of infectious or inflammatory origin; those with nerve root compression; those with a score of less than 2 points on the numerical pain scale in the last seven days, as these are considered very minor pains for intervention purposes; and those with visual and/or auditory impairments that hinder participation and inability to move independently will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-3fkv888	Effects of water-based therapy on balance, mobility, motor function and behavior in children with Autism: a randomized clinical trial	Not yet recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9071	Effects of adding water-based therapy to land-based psychomotor rehabilitation in children with Autism Spectrum Disorder on balance, mobility, motor function and behavior: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-04	Universidade Federal da Bahia	<NULL>	<NULL>	<NULL>	The study will include children aged 5 to 10 years; who have a diagnosis of Autism Spectrum Disorder made by a specialized medical professional; who are at support level 1 or level 2; who are regularly undergoing psychomotor rehabilitation; whose parents or legal guardians consent to participation in the study.	Individuals with fear of water immersion; those who exhibit aggressive behavior; those who are participating in other aquatic activities (such as swimming) at the time of the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-10gcc5f8	Comparison of two membrane types for bone regeneration around immediate dental implants	Not yet recruiting	Intervention	2026-04-08	<NULL>	<NULL>	9072	Evaluation of a bovine pericardium collagen membrane in guided bone regeneration around immediate implants: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-15	Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Inclusion criteria comprise participants aged over 18 years classified as ASA I or ASA II according to the American Society of Anesthesiologists presenting teeth indicated for extraction in the aesthetic zone of the maxilla involving central incisor or lateral incisor or canine or first premolar or second premolar being a single unit. Participants must present transverse root position Class I or Class II or Class III according to Kan and Class I socket with intact buccal wall or Class II socket with up to one third of the buccal wall compromised in addition to buccal recessions of up to 2.0 millimeters and sufficient bone thickness and height for immediate implant placement with primary stability possessing natural teeth adjacent to the element to be extracted.	Patients classified above ASA II or heavy smokers defined as those consuming over 10 cigarettes per day or with a history of radiotherapy in the head and neck region or undergoing chemotherapy for treatment of malignant tumors or patients with uncontrolled diabetes defined as glycated hemoglobin above 7.0 millimoles per liter will be excluded. Also constituting exclusion criteria are the presence of pathological soft tissue alterations in the intervention region such as leukoplakia or lichen planus or erythroplakia and extensive periapical bone pathological alterations that prevent implant placement as well as localized periodontitis in the intervention region or Stage IV Periodontal Disease without occlusal stability or Class IV sockets according to Kan.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-3fn3dm7	How simple hand exercises can help control high Blood pressure in older women	Recruitment completed	Intervention	2026-04-08	<NULL>	<NULL>	9073	Effect of isometric Handgrip Exercise performed with a dynamometer and an anti-stress ball on the cardiovascular responses of elderly hypertensive women	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-03	Faculdade de Educação da Universidade Federal da Bahia	<NULL>	<NULL>	<NULL>	Female;  60 years of age or older;  have been diagnosed with hypertension by means of a medical report or self-report that they have hypertension and be using antihypertensive medication prescribed by a physician;  be using antihypertensive medication with a dose maintained for the last 6 months;  not have secondary arterial hypertension and/or target organ damage;  not use medications that directly affect cardiac autonomic regulation (e.g. beta-blockers and non-dihydropyridine calcium channel inhibitors antidepressants);  not have other cardiovascular diseases, in addition to arterial hypertension;  not have grade II or higher obesity;  not have diabetes with complications or use of insulin; and  not have orthopedic changes that make it impossible to practice the isometric resistance training in question;  not be a smoker or have smoked in the last year;  not undergoing hormone therapy	Presenting resting blood pressure above 160 mmHg for systolic blood pressure and/or 100 mmHg for diastolic blood pressure on the day of the exercise in two consecutive reschedulings;  impossibility of continuing the collection for health reasons or any other reason raised by the participant;  deciding to leave the study voluntarily;  impossibility of carrying out the experimental sessions (intervention and control) with a time interval of less than 3 weeks	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-9w6hdgt	The Effect of Manual Therapy on Female Sexual Pain: A Multicenter, Randomized, Controlled, Blinded Clinical Trial	Not yet recruiting	Intervention	2026-04-07	<NULL>	<NULL>	9061	Female Sexual Pain	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade Federal do Delta do Parnaíba - UFDPar	<NULL>	<NULL>	<NULL>	Female volunteers experiencing pain during penetrative sexual activity (dyspareunia); aged between 18 and 40 years; able to understand and respond appropriately to the assessment instruments; have up-to-date gynecological examinations; be available to participate in all stages of the study; and sign the Informed Consent Form	Pregnant volunteers; volunteers in the postpartum period; diagnosed with serious neurological, rheumatological, oncological, or gynecological diseases; history of recent pelvic surgeries; presence of active genital infections; volunteers who have undergone pelvic physiotherapy treatment for sexual pain	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-10hp9qxg	Passagem study: lifestyle, sleep, health, nutrition, and bullying - monitoring in youth from Passagem, Rio Grande do Norte, Brazil	Not yet recruiting	Observational	2026-04-07	<NULL>	<NULL>	9062	PASSAGEM Study: physical ativity, sleep, health, diet, and bullying profile – Epidemiological monitoring among adolescents in Passagem, Rio Grande do Norte, Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Programa de Pós-graduação Stricto Sensu em Educação Física da Universidade Católica de Brasília - PPGEF-UCB	<NULL>	<NULL>	<NULL>	Adolescents of both sexes, aged 10 to 19 years, living in the municipality of Passagem, Rio Grande do Norte, Brazil, and registered or assisted by Primary Health Care Units will be eligible for inclusion in the study. Participation will require the presentation of a Written Informed Consent Form signed by parents or legal guardians for participants under 18 years of age, or by the participant when aged 18 or 19 years, as well as the Written Assent Form signed by adolescents younger than 18 years.	Adolescents presenting physical, cognitive, or mental conditions that prevent understanding the instructions or adequately completing the questionnaires will be excluded from the study, according to self-report by the adolescent and/or information provided by a legal guardian at the time of the invitation to participate. Adolescents who refuse to participate or withdraw at any stage of the data collection will also be excluded. Questionnaires with missing responses in the main study variables will be considered sample losses.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-9d26qz7	Comparison of the effects of antibiotic use on pain and infection symptoms after lower third molar removal surgery: a randomized, triple-blind clinical trial	Recruitment completed	Intervention	2026-04-07	<NULL>	<NULL>	9063	Comparison of the clinical effects of postoperative antibiotic therapy in the prevention of local and systemic infections after third molar surgeries: a randomized, triple-blind clinical study	<NULL>	2, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Obras Sociais e Educacionais de Luz	<NULL>	<NULL>	<NULL>	Patients of both genders; aged between 18 and 35 years; who do not present Local or Systemic Pathologies; having impacted lower third molars that require Osteotomy and/or Odontosection	Patients who are allergic to the medications used in the study; individuals who were not interested in participating in the research; diagnosis of Cardiac Diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-8xq89wg	How the use of dentures may influence taste and the perception of flavors in older adults	Terminated	Observational	2026-04-07	<NULL>	<NULL>	9064	Influence of complete dentures on taste and flavor intensity detection in elderly patients: a cross-sectional cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-12	Faculdade de Odontologia do Campus de Araçatuba - UNESP	<NULL>	<NULL>	<NULL>	Both sexes; minimum age of 55 years; with cognitive ability to respond to the questions applied in the selected tests; users of complete bimaxillary dentures for at least 6 months	Previous history of head and neck cancer; having undergone radiotherapy and/or chemotherapy; neurological disorders or cognitive impairments; history of respiratory and/or pulmonary diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-6jt2f8b	Use of Low-Intensity Laser with Methylene Blue to treat Nipple Cracks during Breastfeeding	Not yet recruiting	Intervention	2026-04-07	<NULL>	<NULL>	9065	Effect of Low-Intensity Laser at the red wavelength associated with Methylene Blue for the treatment of Breast Fissures: a randomized controlled trial	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal do Delta do Parnaíba	<NULL>	<NULL>	<NULL>	Postpartum women; aged between 18 and 40 years; who present with unilateral or bilateral nipple fissures, confirmed by a healthcare professional, for at least 1 week; with reported nipple pain greater than or equal to 5 on the Visual Analogue Scale (VAS); who are exclusively breastfeeding; those who agree to participate in the study must sign the Informed Consent Form, present in Appendix A	Postpartum women with active breast infection; participants undergoing any other topical treatment for the fissure, such as healing ointments, antibiotics, antifungals, or corticosteroid therapy; patients with a history of autoimmune skin diseases, atopic dermatitis in the breast area, or breast cancer; HIV/AIDS positive; participants with contraindications to photonic therapy; people with psychiatric disorders; and those who request to be withdrawn from the research.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-96dxm62	How Pilates can help with blood pressure and circulation in individuals with high blood pressure	Not yet recruiting	Intervention	2026-04-07	<NULL>	<NULL>	9066	Effects of the Pilates method on ambulatory blood pressure and central hemodynamics in individuals with arterial hypertension	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-15	Universidade Estadual de Maringá – Centro de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Individuals of both sexes.Age equal to or greater than 30 years.Sedentary or irregularly active for at least six months (not meeting greater than or equal to 150 minutes per week of moderate physical activity or 75 minutes per week of vigorous physical activity).Diagnosis of systemic arterial hypertension (SAH), stage I or II, according to the Brazilian Hypertension Guidelines.Use of antihypertensive medications of any class.Medical clearance for physical exercise (medical statement/report).Agreement to sign the Informed Consent Form (ICF)	Cognitive impairment that compromises the ability to respond to the initial assessment questionnaire.Diagnosis of type 1 or type 2 diabetes mellitus.Relevant endocrine diseases.Current smoking.Orthopedic or neuromuscular conditions that prevent the performance of the exercises.Changes in medication during the study.Cardiovascular symptoms such as palpitations, exertional angina or other conditions that prevent continuation of the protocol.Pregnancy.Attendance lower than 75% of the scheduled sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:16
RBR-76kmb7g	Ayahuasca in the treatment of alcohol addiction	Recruitment completed	Intervention	2026-04-06	<NULL>	<NULL>	9057	Effects and therapeutic potential of ayahuasca in alcohol use disorder	<NULL>	1-2, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Men and women aged 25 or older; currently diagnosed with alcohol use disorder; concerned about their drinking habit; with preserved cognitive abilities; and with a family member or friend who can pick them up after ayahuasca sessions	presence of kidney liver heart or esophageal diseases; presence of psychiatric symptoms (acute psychosis suicidal ideation bipolar disorder or severe symptoms of depression or anxiety); current use of selective serotonin reuptake inhibitor drugs or monoamine oxidase inhibitors at the time of the study; current use of natrexone disulfiram acomprosate methylphenidate or baclofen; clinical indication for hospitalization; clinical indication for the treatment of alcohol withdrawal symptoms	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-6rrhxqg	Study on the brain health of the population of Porto Alegre	Recruitment completed	Intervention	2026-04-06	<NULL>	<NULL>	9058	Porto Alegre brain health initiative	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-26	União Brasileira de Educação e Assistência	<NULL>	<NULL>	<NULL>	Adults of both sexes; aged 40 to 59 years; residing in Porto Alegre (RS, Brazil); physically inactive or not engaged in regular physical exercise; in adequate health conditions to undergo the proposed physical and cognitive assessments; able to provide written informed consent; participants with controlled anxiety or depression may be included	Diagnosis of neurodegenerative diseases or severe psychiatric disorders; medical conditions that prevent participation in physical effort tests, biological exams, or cognitive assessments; participation in other clinical studies that may interfere with the results of this research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-4wqy488	Clinical effects of an anti-inflammatory diet in Type 2 Diabetes	Recruiting	Intervention	2026-04-06	<NULL>	<NULL>	9059	Determining the clinical effects of an anti-inflammatory microbiome restoration diet (RESTORE) in patients with Type 2 Diabetes using a strictly controlled nutritional intervention study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-10	Universidade Federal de Goiás	<NULL>	<NULL>	<NULL>	Non-vegetarian or vegan men and non-vegetarian/vegan women; non-pregnant and non-lactating; aged between 20 and 65; diagnosis of DM2 without target organ failure; glycated hemoglobin (HbA1c) between 6.0% and 12%; BMI &gt; 25 kg/m2	Presence of type 1 diabetes; use of insulin or more than three glucose reducing agents; history of ketoacidosis, myocardial infarction, stroke, angina or insufficiency in the last six months; diabetic retinopathy requiring treatment; kidney or liver disease; cancer requiring treatment in the last 5 years (with the exception of non-melanoma skin cancer); severe psychiatric disorder currently uncontrolled; allergy or other inflammatory and/or endocrine conditions; severe gastrointestinal symptoms; chronic use of laxative or anti-inflammatory medications; abuse of alcohol (&gt;7 drinks per week), tobacco (smoking or chewing); illicit drugs or marijuana; vigorous exercise &gt;5 hours per week; allergy or intolerance to any foods or ingredients in the dietary intervention; use of probiotics, prebiotics, fiber, omega-3 fatty acids or herbal supplements (patients will be eligible two weeks after discontinuation); use of antibiotics (patients will be eligible four weeks after discontinuation)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-6p53r5s	Program with digital support and personalized guidance to improve lifestyle habits of low-income older women	Not yet recruiting	Intervention	2026-04-06	<NULL>	<NULL>	9060	Effect of a hybrid social prescribing and digital support intervention on lifestyle determinants of low-income older women: a randomized mixed-methods clinical study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-30	Centro de Ciências Biológicas e da Saúde - Universidade Federal de São Carlos	<NULL>	<NULL>	<NULL>	Women aged 60 to 75 years; living in São Carlos-SP; who express interest in participating and meet the established criteria; especially age; place of residence; and individual income of up to 2 minimum wages	Women with significant cognitive impairment identified by the CS-10; which may compromise understanding of the instructions or autonomous completion of the assessment instruments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-5fvwf5w	Evaluation of the use of toothpaste with Brazilian red propolis to relieve tooth sensitivity.	Not yet recruiting	Intervention	2026-04-05	<NULL>	<NULL>	9056	Evaluation of the potential for controlling dentin hypersensitivity with the use of red propolis toothpaste brazilian: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Instituto Leão Sampaio de ensino universitário	<NULL>	<NULL>	<NULL>	Age 18 or older; Presence of dentin hypersensitivity; Teeth (incisors, canines, premolars, or first molars) with a positive response to evaporative cold air stimulus on the Schiff Sensitivity Scale.	Pregnant women; Patients who underwent teeth whitening up to 8 weeks before the start of the study; Patients with a history of allergy to the components of the study material; Use of toothpaste or other type of desensitizing agent in the 30 days prior to the study; Teeth with mobility; Teeth with deep and defective restorations; Teeth with caries, fissures, fractures or any sign of pulpitis; Teeth with a history of trauma; Teeth used as abutments for removable partial dentures; History of allergy to propolis.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-7mmz8tj	Motor control in people with Duchenne Muscular Dystrophy	Recruiting	Intervention	2026-04-02	<NULL>	<NULL>	9050	The effects of Galvanic Vestibular Stimulation on posture and movement in people with Duchenne Muscular Dystrophy	<NULL>	n/a, n/a, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-10	Universidade Municipal de São Caetano do Sul	<NULL>	<NULL>	<NULL>	Sensory-motor sequelae of the muscle weakness type with functional impairment in activities of daily living, postural control, mobility and reach, grasping, and manipulation; over 4 years of age; under medical supervision for your condition; following prescribed medical guidelines	The exclusion criteria will be having any uncompensated clinical changes; having a metal implant in the skull; experiencing seizures; having a pacemaker or other type of neuromodulator	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-5r9j6kg	Effects of Palatal Expansion on the Oral and General Health of Children with Enlarged Adenoids and Tonsils	Recruiting	Intervention	2026-04-02	<NULL>	<NULL>	9051	Effects of Rapid Maxillary Expansion on the Oral and General Health of Patients with Hypertrophic Adenoids and Palatine Tonsils: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-19	Departamento de Estomatologia	<NULL>	<NULL>	<NULL>	Children aged 5 to 7 years; of both sexes; who require surgical intervention (adenotonsillectomy); presenting with maxillary atresia; and with unilateral or bilateral posterior crossbite, whether apparent or functional.	Children requiring other modalities of interceptive orthodontic treatment during the experimental period; patients using medications that alter bone metabolism; patients with a body mass index greater than twenty-five; patients with craniofacial malformations; and patients with cognitive impairments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-786s55w	Impact of herbal blend on amateur runners: hidden clinical study	Data analysis completed	Intervention	2026-04-02	<NULL>	<NULL>	9052	Effects of acute supplementation with Alpinia galanga and maca root on markers of athletic performance in amateur runners: a randomized, double-blind, crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-07	União Brasileira de Educação e Assistência	<NULL>	<NULL>	<NULL>	amateur runners of both sexes; aged between eighteen and fortyfive years; who have been training for running for at least six months; and who engage in at least one hundred and fifty minutes of physical activity per week	individuals diagnosed with any chronic disease or condition such as hypertension; type one or type two diabetes mellitus; as well as those using dietary supplements or medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-8wxk5kh	How movement and everyday skills are connected in children with ADHD and ASD	Recruiting	Intervention	2026-04-02	<NULL>	<NULL>	9053	Relationships between motor performance and functionality in children with ADHD and ASD	<NULL>	n/a, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-17	Escola de Educação Física da Universidade de Minas Gerais	<NULL>	<NULL>	<NULL>	Male sex; age between 7 and 16 years; diagnosis of Attention Deficit Hyperactivity Disorder; currently using medication for Attention Deficit Hyperactivity Disorder; absence of musculoskeletal injuries; no contraindication to Transcranial Direct Current Stimulation	Participants who do not complete the tasks related to motor performance assessment or the application of Transcranial Direct Current Stimulation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-2fyn375	Use of a dental mousse to reduce tooth sensitivity after dental bleaching	Recruiting	Intervention	2026-04-02	<NULL>	<NULL>	9054	Effect of the Use of CPP-ACP Mousse in the Management of Post-Bleaching Dental Sensitivity – Randomized, Double-Blind Clinical Study	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Centro universitário UNIVEL	<NULL>	<NULL>	<NULL>	Age between 18 and 30 years; both sexes; presence of all vital anterior teeth; absence of previous dental bleaching; absence of restorations in the anterior region; central incisors with shade A2 or darker according to the Vitapan Classical shade guide; agreement to participate in the study by signing the Informed Consent Form	Absence of anterior teeth; presence of active carious lesions; presence of gingival recession; previous restorative or prosthetic treatment in the anterior region; history of dentin hypersensitivity; tooth discoloration caused by tetracycline use or dental fluorosis; continuous use of anti inflammatory or analgesic medications; pregnancy or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-834k44k	Use of intravenous iron to treat anemia before gynecological surgery	Not yet recruiting	Intervention	2026-04-02	<NULL>	<NULL>	9055	Impact of Intravenous infusion of Ferric hydroxide sucrose in Anemic patients undergoing Gynecological surgeries: Randomized, controlled, double-blind study.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-15	Universidade Federal do Rio de Janeiro	<NULL>	<NULL>	<NULL>	The patients studied will be female, over 18 years of age, with an indication for elective hysterectomy with or without oophorectomy and/or annexectomy and myomectomy at HUCFF/UFRJ. Patients with anemia due to absolute or functional iron deficiency, Hg &lt; 12g/dl; ferritin &lt; 30 mcg/L or 30-300 mcg/L with transferrin saturation &lt; 20%	Individuals under 18 years of age. Patients who have received treatment with packed red blood cells before entering the protocol within the last 3 months. Patients undergoing urgent/emergency surgery. Patients with a formal contraindication to the use of intravenous iron, such as known hypersensitivity. Conditions that lead to secondary iron overload, such as: hereditary hemolytic anemias, myelodysplastic syndrome, Fanconi anemia. Anemias of other non-iron deficiency etiologies. Septic patients and pregnant women in the first trimester. Patients whose surgery was canceled or not performed. Patients participating in another clinical trial. Patients with dialysis-dependent renal failure.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-10682pyr	Bone and gingival modifications around implants with immediate prosthesis installed by guided surgery	Recruiting	Intervention	2026-04-01	<NULL>	<NULL>	9046	Bone remodeling and soft tissue changes in immediate implants subjected to immediate loading and installed using the guided surgery and prosthesis technique	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Good general health (physical and mental) at the time of the surgical procedure; agreement with the informed consent; Individuals between 18 and 60 years of age; patients of both genders; need for implant placement in the anterior region due to teeth indicated for extraction	Smokers; alcohol abuse; drugs or medicines; positive history of systemic diseases that interfere with bone metabolism or treatment safety; coagulation disorders; serious heart disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-5zf4ntf	The effect of knee Nerve Blockade on pain relief in knee Arthrosis	Recruiting	Intervention	2026-04-01	<NULL>	<NULL>	9047	Radiofrequency Neuromodulation in the treatment of knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-10	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	<NULL>	<NULL>	<NULL>	Both genders; Patients diagnosed with advanced knee OA (Ahlback &gt;3); Age between 60 and 80 years; Chronic pain for more than 6 months, with an intensity ≥5 on the Visual Analog Scale (VAS, graded from 0 to 10); Access to a smartphone with WhatsApp and the cognitive ability to answer questions on this application; Patients on the waiting list for total knee arthroplasty (TKA) at INTO	Angular deformities &gt;10° in the coronal plane or &gt;10° in the sagittal plane; Morbid obesity; Uncontrolled diabetes; Coagulopathies; Psychiatric disorders or chronic use of anxiolytics/opioids; History of articular infection, previous surgery, or aritcular injection of corticosteroids/hyaluronic acid in the last 3 months; Presence of neoplasia in the affected knee, pacemaker, or implanted neurostimulators; Positive result on the neuropathic pain questionnaire (DN4), according to Santos et al. (2010) and Mayoral et al. (2018)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-34sj2yx	Validation of NAT Chagas and LAMP Chagas for the diagnosis of patients and foods involved in oral outbreaks of Chagas disease	Recruiting	Observational	2026-04-01	<NULL>	<NULL>	9048	Comparative validation of the Biomol Chagas (NAT Chagas) and Loopamp (LAMP Chagas) kits in samples from acute and recent chronic patients and food involved in oral outbreaks of Chagas disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-02	Fundação Oswaldo Cruz	<NULL>	<NULL>	<NULL>	The study is conducted with people of both sexes, being individuals aged 1 year and older with clinical and/or epidemiological suspicion of Chagas disease transmitted orally or who have undergone direct parasitological and/or serological examinations with confirmed results; Must have voluntarily signed the Informed Consent Form and/or Informed Consent Form for the study; Participants who agree to provide sufficient biological material for analysis	Having received specific treatment with Benznidazole, Nifurtimox, or any agent with recognized trypanocidal activity less than 1 year ago; For individuals in the chronic phase, with proven infection by Trypanosoma cruzi that occurred more than 1 year ago; Indigenous population	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-5spb46p	Postural control in soccer players athletes	Recruiting	Intervention	2026-04-01	<NULL>	<NULL>	9049	Effects of Galvanic Vestibular Stimulation on athletes&apos; postural balance performance	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Municipal de São Caetano do Sul	<NULL>	<NULL>	<NULL>	Be male; be between 14 and 20 years of age; regularly participate in training sessions and games for your respective team and category; be monitored by a training team; be able to participate in a game without complaints of dyspnea or cardiorespiratory fatigue	Have acute musculoskeletal injury or undergoing treatment; have sensitivity changes; have uncorrected visual changes; have uncompensated vestibular changes; be using psychostimulants	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-9hdqfcp	Parasternal block and chronic pain in patients undergoing cardiac surgery	Recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9040	Parasternal block and chronic postoperative pain in patients undergoing cardiac surgery: Prospective, randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-30	Fundação Paraibana de Gestão em Saúde - PB Saúde.	<NULL>	<NULL>	<NULL>	Patients of both sexes who will undergo cardiac surgery; age between 18 and 80 years	Patients with puncture site infection; patients with systemic infection or hemodynamic instability	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-7w6pmpg	Effect of a plant-based diet on vascular health, cardiometabolic risk factors, body composition, and muscle function.	Not yet recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9041	Effect of dietary monitoring based on a plant-based diet on vascular health, cardiometabolic risk factors, body composition, and muscle function.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal do Rio de Janeiro Campus Macaé	<NULL>	<NULL>	<NULL>	Adults: age between 18 and 59 years; both sexes; physically active (more than 150 minutes per week of physical activity). Older adults: age equal to or greater than 60 years; both sexes; eutrophic (body mass index between 22 and 27 kg/m²); physically active (more than 150 minutes per week of physical activity)	Adults: decompensated cardiovascular diseases; uncontrolled diabetes; pulmonary disease; smoking; urinary infection; pregnancy; lactation; use of medications that interfere with amino acid metabolism or nitric oxide production; use of antibiotics or anti-inflammatory drugs; use of nutritional supplements, multivitamins, or pharmacological agents. Older adults: diagnosis of severe decompensated cardiovascular disease; uncontrolled diabetes; pulmonary disease; smoking; urinary infection; use of medications that interfere with amino acid metabolism or nitric oxide production; use of antibiotics or anti-inflammatory drugs; use of nutritional supplements or pharmacological agents	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-2grxdz7	Effects of Aquatic Physiotherapy on the health and quality of life of elderly people in the community	Not yet recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9042	Effects of Aquatic Physiotherapy on functionality, fear of falling, pain, well-being, and quality of life of community-dwelling elderly	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-11	Universidade Estadual de Goiás	<NULL>	<NULL>	<NULL>	People aged 60 or older; of both sexes; who are able to walk with or without the aid of walking aids	Older adults with severe cognitive impairment that precludes the use of assessment tools; older adults with contraindications to immersion in a therapeutic pool (uncontrolled blood pressure, severe heart failure, severe kidney disease, fever, recent surgery, uncontrolled epilepsy, low vital capacity, and deep vein thrombosis); or those who are clinically unstable at the time of assessment or intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-3v4k4d6	Evaluation of respiratory muscle function in patients who underwent Liver Transplantation and are admitted to the Intensive Care Unit	Recruiting	Observational	2026-03-31	<NULL>	<NULL>	9043	Evaluation of Diaphragmatic function in patients undergoing Liver Transplantation in the Intensive Care Unit	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-30	Hospital de Clinicas da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Individuals of both genders, aged between 18 and 70 years, after liver transplantation, admitted to the Adult Intensive Care Unit of the State University of Campinas (Unicamp) will be evaluated. Patients who have undergone liver transplantation and are admitted to the unit still requiring ventilatory support via orotracheal tube and mechanical ventilation and are electively extubated will be considered eligible to participate in the study.	patients who for some reason are re-intubated, that is, need to return to mechanical ventilation, who are not conscious and oriented enough to obey commands and re-liver transplants	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-976s5yy	The effect of vitamin C and D supplementation on immunity and performance in marathon runners	Data analysis completed	Intervention	2026-03-31	<NULL>	<NULL>	9044	The effect of vitamin C and D supplementation on the immunity and performance of amateur marathon runners	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-14	Programa de pós-graduação em Educação Física	<NULL>	<NULL>	<NULL>	Runners; male gender; marathon or ultramarathon runners for at least 3 years; aged between 20 and 45 years; training frequency of 3 days per week; average pace of 5:00 to 5:50 km/min in the last half marathon completed; no reported injuries in the last 6 months	Participants who are taking any other vitamin C and D supplements; have not completed a nutritional recall; or have completed a run longer than 5 km in the two days preceding the 42 km race will not be eligible	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-82tzn4t	Effect of a respiratory physiotherapy technique in infants undergoing cardiac surgery	Not yet recruiting	Intervention	2026-03-31	<NULL>	<NULL>	9045	Effects of the Thoracoabdominal Rebalancing Method in infants undergoing cardiac surgery: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Ciências da Saúde do Trairí	<NULL>	<NULL>	<NULL>	Participants aged between 0 and 24 months; of both sexes; between 12 and 72 hours after cardiac surgical procedures performed via median sternotomy or percutaneous route (catheterization); Infants must present clinical stability that allows respiratory physiotherapy; whether in room air or using oxygen therapy (low or high flow)	Infants with chronic lung disease that compromises respiratory function such as bronchopulmonary dysplasia; those using positive pressure ventilation; those with congenital deformities of the rib cage or shoulder girdle; those who develop diaphragmatic paralysis postoperativel; present hemodynamic instability defined as persistent changes in heart rate or blood pressure outside the limits for age and arrhythmias of difficult control	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-85nknzz	Virtual Reality and Music for pain relief during dressing changes in Vascular Ulcers	Not yet recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9027	Virtual Reality and the use of Music in pain relief during dressing changes in Vascular Ulcers: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Pós Graduação em Enfermagem	<NULL>	<NULL>	<NULL>	Participants aged ≥ 18 years; of both sexes; with the presence of vascular ulcers; without neurological or cognitive conditions that may influence the results of the assessment scales; presenting pain intensity ≥ 4 on the assessment scales	Patients with diagnosed auditory and/or visual impairment or sensitivity; those who have scheduled or have undergone angioplasty of the affected limb during the data collection period; those on continuous use of analgesic medications or who have used such medications within 24 hours prior to data collection, which may interfere with pain during dressing changes; those presenting vestibular system disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-7w6jvrz	How Analgesic Blocks helps relieve shoulder Osteoarthritis pain in patients undergoing surgery: a clinical study	Recruitment completed	Intervention	2026-03-30	<NULL>	<NULL>	9028	Role of Analgesic Blocks in pain control for Glenohumeral Osteoarthritis with surgical indication: a prospective randomized clinical study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-20	Hospital Universitário Pedro Ernesto	<NULL>	<NULL>	<NULL>	Patients of both sexes; aged over 50 years; with symptomatic glenohumeral osteoarthritis and no improvement after appropriate, standard conventional conservative treatment; indicated for shoulder arthroplasty; and with glenohumeral osteoarthritis grades 1 to 5 according to the Hamada classification	Failure to sign the Informed Consent Form; psychiatric and/or cognitive disorders that preclude assessment and follow-up; coagulopathies or International Normalized Ratio greater than 1.5; history of malignant neoplasm within the last five years; orthobiologic procedures performed in the same joint within the past 6 months; stroke or acute myocardial infarction within the last 3 months; intolerance or allergy to local anesthetics; and participation in other studies within the last 30 days	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-3jjkk57	Effect of Light on Skin Inflammation: Follow-up Study	Recruitment completed	Observational	2026-03-30	<NULL>	<NULL>	9029	Evaluation of the Effect of Photobiomodulation in Hidradenitis Suppurativa: A Prospective Study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Hospital de Clínicas da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Participants diagnosed with hidradenitis suppurativa who present with active lesions; individuals over eighteen years of age; patients capable of participating in the study autonomously and without cognitive impairment.	Participants with skin lesions or inflammatory conditions that have not yet been formally diagnosed as hidradenitis suppurativa by a medical professional; individuals who missed more than two consecutive treatment sessions during the four-week intervention period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-4j2cy33	Evaluation of menstrual bleeding pattern and sexual quality of life in women using hormonal or copper intrauterine devices	Recruitment completed	Observational	2026-03-30	<NULL>	<NULL>	9030	Bleeding pattern and sexual quality of life in users of hormonal IUD and copper IUD	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-26	Escola Paulista de Medicina da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women; aged between 18 and 40 years; eligible for the use of an intrauterine device according to the World Health Organization medical eligibility criteria; who chose to use a long-acting reversible contraceptive method, including the levonorgestrel-releasing intrauterine system 19.5 mg or a copper intrauterine device; who agreed to participate in the study by signing the Informed Consent Form	Current pregnancy at the time of inclusion; active genital infection at the time of inclusion or device insertion; medical contraindication to the use of an intrauterine device; refusal to participate in the study or to answer the study questionnaires	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-10kmkjj4	Lifestyle and health of adolescents from southern Bahia	Not yet recruiting	Observational	2026-03-30	<NULL>	<NULL>	9031	CRISCO-BA Study: health risk behaviors among adolescents in southern Bahia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-04	Universidade Católica de Brasília - UCB	<NULL>	<NULL>	<NULL>	"Students of both sexes; aged between 14 and 19 years; regularly enrolled in the integrated technical
high school programs at the  Federal Institute of Education, Science and Technology of Bahia, Ilhéus campus; presentation of the Informed Consent Form signed by parents or guardians for those under 18 years old, or by the adolescents themselves for those aged 18 or 19; presentation of the Assent Form signed by adolescents under 18 years old"	Physical and/or mental conditions that compromise safe participation, such as inability to understand or respond to questionnaires, severely reduced mobility; pregnant adolescents; absence on assessment days,resulting in incomplete data; and voluntary withdrawal	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-738r9nh	In-person and remote cardiac rehabilitation for patients with chronic heart disease	Recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9032	Cardiovascular rehabilitation in in-person and telerehabilitation modalities associated with the validation of the respiratory diagnostic assistant (RDA) prototype in the respiratory pattern of patients with chronic heart disease	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-10	Departamento de fisioterapia	<NULL>	<NULL>	<NULL>	Clinical diagnosis of heart failures with ejection fraction equal or greater than 40%, New York Heart Association (NYHA) functional class II and III, sedentary adults, both genders, age 21-65, smartphone with internet acess	Patients with unstable angina, myocardial infarction, or cardiac surgery within 3 months prior to study initiation, respiratory disorders, pregnant women, smokers or former smokers for less than 5 years, hemodynamic instability, recent facial trauma, orthopedic or neurological conditions that prevent the performance of exercises	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-35hy87d	Association between spots on tooth enamel and facial growth pattern	Recruiting	Observational	2026-03-30	<NULL>	<NULL>	9033	Association between Molar-Incisor Hypomineralization (MIH) and facial growth pattern	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-03	Universidade Federal de Minas Gerais - Faculdade de Odontologia UFMG	<NULL>	<NULL>	<NULL>	Orthodontic documentation of patients aged between eight and twenty five years	Patients with craniofacial anomalies or deformities that can be identified in orthodontic records; Patients with cognitive deficits reported by parents in the anamnesis form included in the orthodontic documentation file	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-2phymmg	Study on tolerance and safety of different doses of Magic Mushroom Extract in healthy adults	Not yet recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9034	Evaluation of the tolerability and safety of administering different doses of purified Psilocybin extract in healthy adults	<NULL>	1, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Instituto Alma Viva Limitada - ltda	<NULL>	<NULL>	<NULL>	Adults without comorbidities aged between 21 and 65 years from both gender	Participants  not eligible for the study are using of antidepressive drugs; have history of heart; liver; kidney disease; history of cancer or organ transplant; insulin dependent diabetes or uncontrolled diabetes; gastrointestinal disease that may interfere with the absorption of the substance orally; current or past history of psychiatric disorders as schizophrenia; psychotic disorder; bipolar disorder; personality disorder; first degree family history of psychiatric disorders; seizures or fainting; creatinine elevation; nicotine dependence that would prevent an individual from being nicotine-free for 7 to 10 hours during the dosing period; women who are pregnant or intending to become pregnant during the study or who are currently breastfeeding; chemical dependency or abuse of alcohol or illicit drugs in the last 12 months; platelets disorders;  clinically significant anemia and liver injury	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-10zwj9cs	Use of Non-invasive Brain Stimulation to aid physical recovery in street runners.	Not yet recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9035	Transcranial Direct Current Stimulation as a Recovery Tool in Street Runners: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-05	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	<NULL>	<NULL>	<NULL>	Be between 18 and 45 years of age; Be a practicing street runner, having practiced this sport uninterruptedly for at least one year, with a training routine of at least 2 times a week; Have been able to run 5 km continuously in the time interval between 30 and 45 minutes at least 2 times a year; Not present severe cardiorespiratory and/or metabolic alterations; Not report musculoskeletal disorders in the lower limbs and spine in the last 6 months that have prevented the maintenance of the training routine; Not have used anti-inflammatory drugs, corticosteroids, analgesics or muscle relaxants in the 30 days preceding the start of the study; Not have used ergogenic resources, such as anabolic steroids, in the last 6 months preceding the start of data collection; Not have a neurological deficit that could compromise the follow-up and understanding of the interventions, as well as not using implanted metallic devices, and not be pregnant; Not having metal implants in the trunk and/or upper limbs	Failure to complete the 5km run within 45 minutes; Failure to correctly perform the assessment procedures; Use of anti-inflammatory drugs, corticosteroids, analgesics, or muscle relaxants during the data collection period; Undergoing other types of muscle recovery interventions during the research, such as cryotherapy or relaxing massage	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-4mbx874	Vitamin D levels, dietary intake and muscle strength in women with breast cancer: a comparative study	Not yet recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9036	Vitamin D status, dietary intake, and muscle mass in women with Breast Cancer: a cross-sectional, longitudinal, and randomized clinical trial study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-09-01	Pró Reitoria de Pesquisa da Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Women aged 45 years or older; with breast cancer regardless of tumor histological subtype; clinical stage (I to IV), provided they are clinically stable and able to provide written informed consent (Informed Consent Form – ICF); who, at the end of Phase 2, present significant loss of lean body mass and development of vitamin D deficiency in the post-oncological treatment period	Presence of autoimmune diseases or neurological disorders that may hinder the interview; HIV infection; congenital muscular disorders; prolonged immobilization; significant muscle dysfunction; history of malignant neoplasms other than breast cancer; continuous use of vitamin D supplementation; contraindications to ultrasonography or other complementary examinations	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-32xntk4	Use of digital games to support recovery of movement and thinking during rehabilitation	Recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9037	Serious games as a tool for motor and cognitive rehabilitation in different rehabilitation settings	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-02	Faculdade de Engenharia Elétrica	<NULL>	<NULL>	<NULL>	Manual wheelchair users of both sexes; aged between 18 and 65 years; clinical diagnosis of shoulder dysfunction due to repetitive wheelchair use; preserved cognitive capacity to understand and follow study instructions; internet access and a device compatible with the telerehabilitation platform	Other orthopedic or neurological conditions affecting upper limb mobility; history of recent shoulder surgery (less than six months); current use of opioid analgesics for pain management; simultaneous participation in another rehabilitation program	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-43ynm4d	Use of local anesthetic in hysteroscopy: impact on pain and patient&apos;s experience	Recruitment completed	Intervention	2026-03-30	<NULL>	<NULL>	9038	Analysis of intrauterine Lidocaine use in office hysteroscopy through evaluation of patient&apos;s pain and satisfaction	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-01	Sociedade Benef Israelita Bras Hospital Albert Einstein	<NULL>	<NULL>	<NULL>	All patients seen at the Office Hysteroscopy service of the Vila Santa Catarina Municipal Hospital until the number of 140 patients with complete data is reached, regardless of the clinical condition presented for evaluation of the uterine cavity; who have signed and agreed to the Informed Consent Form	Patients with known hypersensitivity to amide-type local anesthetics or, more specifically, to lidocaine hydrochloride; who present with insurmountable cervical stenosis during the procedure; patients with a history of cervical or endometrial cancer; and patients with a history of cervical surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-10nrrpqx	The benefits of Intermittent Pneumatic Compression Boots for muscle soreness, strength and performance in runners	Recruiting	Intervention	2026-03-30	<NULL>	<NULL>	9039	Effectiveness of Intermittent Pneumatic Compression on neuromuscular recovery in runners: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-19	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	<NULL>	<NULL>	<NULL>	Recreational runners (someone who runs 1 to 3 times a week for 6 months); female; aged between 18 and 65 years	Any medical condition incompatible with the research procedures; history of deep vein thrombosis; abrasions; altered sensation in the lower limbs; musculoskeletal pain/discomfort at baseline	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-5cmx2g3	Removal of tumors after chemotherapy given before surgery for Breast Cancer	Recruiting	Observational	2026-03-27	<NULL>	<NULL>	9022	Vacuum-Assisted Percutaneous Excision after neoadjuvant systemic therapy for Breast Cancer	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-15	Empresa Brasileira de Serviços Hospitalares	<NULL>	<NULL>	<NULL>	patients (women) after neoadjuvant systemic treatment for breast cancer; with pre-systemic treatment tumors smaller than or equal to 5 centimeters; with a clinically normal armpit or with a slight suspicion of involvement by breast cancer; single vision; with post-neoadjuvant residual lesions smaller than or equal to 2 centimeters; with a clinically normal armpit or with a slight suspicion of involvement by breast cancer; no residual lesion after neoadjuvant treatment (complete clinical response); with tumor bed marked with systemic pre-treatment clip; with a clinically normal armpit or with a slight suspicion of involvement by breast cancer; over the age of 18	patients with locally advanced tumors; patients with breast implants undergoing percutaneous vacuum excision; legally incapable patients; pregnant and breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-3r5k63t	Pea protein isolate: effects on blood amino acids after consumption	Not yet recruiting	Intervention	2026-03-27	<NULL>	<NULL>	9023	Effect of acute pea protein isolate consumption on plasma amino acid profile in healthy individuals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Healthy adult and elderly individuals (age ≥19 years). Only individuals who agree to participate in the study by signing the Informed consent form will be included	Individuals with any inflammatory process; pulmonary; cardiovascular; degenerative; neurological; or rheumatic diseases; cancer; diabetes mellitus; smokers; alcoholics; pregnant women; those using medication or any type of dietary supplement in the last 4 weeks prior to data collection or those with allergies or intolerance to the intervention will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-9syxzh3	Effect of Transcranial Electrical Stimulation and Intensive Physical Therapy in Cerebral Palsy	Data analysis completed	Intervention	2026-03-27	<NULL>	<NULL>	9024	Effect of Transcranial Direct Current Stimulation and Intensive Physical Therapy in Spastic Diparetic Cerebral Palsy	<NULL>	n/a, n/a, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-10	Departamento de Ciências do Movimento Humano da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Adolescent diagnosed with spastic diparetic cerebral palsy; ability to understand and follow simple instructions; availability to participate in all intervention and assessment sessions; absence of medical contraindications for undergoing transcranial direct current stimulation.	Presence of other neurological conditions that may affect the evaluation of results; presence of metallic implants or electrical devices in the skull that may interfere with the use of tDCS; history of uncontrolled seizures.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-8b3wfmb	Comparison of the effects of three Physical Training protocols in asthmatic children	Not yet recruiting	Intervention	2026-03-27	<NULL>	<NULL>	9025	Comparison of the effects of three Physical Training protocols on clinical outcomes of children diagnosed with Asthma	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade Estadual de Londrina - UEL	<NULL>	<NULL>	<NULL>	Individuals aged between eight and 12 years; of both sexes; with a clinical diagnosis of asthma; who correctly use medication for control; do not practice physical exercise (except in school physical education); and who do not present cognitive, systemic, and motor alterations that could limit the performance of the study	Not completing all assessments; requiring hospitalization or abandoning the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-5ky68sc	Effect of a supplement combined with exercise on muscle loss and recovery in older adults	Recruiting	Intervention	2026-03-27	<NULL>	<NULL>	9026	Angiotensin-(1-7): its applications in the management of lean mass loss and muscle recovery	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Universidade Federal de Ouro Preto	<NULL>	<NULL>	<NULL>	older adults aged 65 years or older residing in the cities of ouro preto and mariana; presenting skeletal muscle loss; presenting any level of sarcopenia including severe sarcopenia; who agree to participate in the proposed intervention	participants who do not meet the inclusion criteria; who refuse to sign the informed consent form; who do not fully complete the research instruments; who do not demonstrate interest in participating in the intervention; individuals with severe liver disease; limiting cardiovascular disorders; severe renal impairment; dementia; parkinson disease; severe neuropsychological disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-9rhyqy4	How can a jump training program in Pilates benefit elderly people?	Data analysis completed	Intervention	2026-03-26	<NULL>	<NULL>	9015	Analysis of the Jump Exercise on the Pilates Reformer Apparatus	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade do Estado de Santa Catarina	<NULL>	<NULL>	<NULL>	Adults aged 60 years or older; Both sexes; Previous participation in Pilates classes for at least six months with a frequency of two or more sessions per week; availability to attend the 12 intervention sessions during the study period; signed informed consent form	Severe cognitive impairment; cardiovascular or respiratory disorders; hypertension; history of musculoskeletal or joint injuries and/or bone fractures in the lower limbs in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-4h27jmk	AK001 Probiotic and Type 2 Diabetes: Efficacy and Safety Evaluation	Not yet recruiting	Intervention	2026-03-26	<NULL>	<NULL>	9016	Safety and efficacy evaluation of AK001 probiotic supplementation in patients with Diabetes Mellitus 2	<NULL>	2-3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-30	Hospital Ana Nery	<NULL>	<NULL>	<NULL>	Individuals aged 30 to 65 years; of both sexes; with a confirmed diagnosis of Type 2 Diabetes Mellitus (T2DM); participants on stable metformin therapy (for at least 4 weeks at a stable dose); informed consent	Participants not receiving pharmacological treatment for glycemic control; participants who used probiotics and/or prebiotics in the month prior to the study inclusion visit; participants using antibiotics; presence of active autoimmune or infectious diseases; participants using other glucose-lowering agents beyond those permitted by the protocol (metformin); patients using hyperglycemic medications (e.g., glucocorticoids, thiazides, phenytoin, estrogens, beta-blockers, pentamidine, interferon, and others); chronic or acute kidney disease or any other medical condition, according to the investigator’s assessment; chronic pain from causes other than diabetic neuropathy; pregnancy or breastfeeding; allergy to any of the active ingredients or excipients of the product under study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-5t669rr	Effects of physical exercise on land and in water in adolescents with Congenital Heart Disease	Not yet recruiting	Observational	2026-03-26	<NULL>	<NULL>	9017	Effects of physical training on land and in water in adolescents with Congenital Heart Disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-30	Universidade Estadual de Londrina - UEL	<NULL>	<NULL>	<NULL>	Adolescents between 12 and 20 years of age; of both sexes; diagnosed with Congenital Heart Disease; hemodynamically stable; who have undergone heart surgery; present some residual alteration and do not practice regular physical exercise; do not have a respiratory infection or hospitalization in the last three months; do not use a pacemaker	Moderate to severe arrhythmias; orthopedic or neurological conditions that prevent evaluations and proposed treatment; failure to complete all evaluations or withdrawing from the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-106mnjhr	Effect of Electrical Stimulation on pain control after facial bone correction surgery in patients with Cleft Lip and Palate	Recruiting	Intervention	2026-03-26	<NULL>	<NULL>	9018	Evaluation of the effect of Transcutaneous Electrical Nerve Stimulation (TENS) on postoperative pain control in Orthognathic Surgery patients with Cleft Lip and Palate	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients presenting with unilateral (left or right side) or bilateral cleft lip and palate. Who are candidates for and eligible for bimaxillary orthognathic surgery. Patients aged 18 years or older. Both sexes	Patients with syndromes. Individuals who have previously undergone orthognathic surgery. Patients with rare facial clefts. Patients with cardiac pacemakers or other implantable electronic devices. History of uncontrolled epilepsy. Pregnant women. Presence of neoplasms in the area of ​​application of Transcutaneous Electrical Nerve Stimulation - TENS. Presence of skin lesions, local infection, areas with altered sensitivity, or any condition that prevents proper electrode placement. Hypersensitivity or intolerance to electrical stimulation. Patients with previous chronic craniofacial pain (such as migraine, trigeminal neuralgia, chronic headaches, post-herpetic neuralgia, fibromyalgia, or other chronic pain syndromes). Patients who have contraindications to the standardized postoperative medication protocol (Sodium Dipyrone and Dexamethasone), such as hypersensitivity, decompensated diabetes mellitus, or other clinical conditions that prevent its administration	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-4ks3bmv	Study comparing Levobupivacaine and Ropivacaine in pain relief after foot and ankle surgeries	Not yet recruiting	Intervention	2026-03-26	<NULL>	<NULL>	9019	Use of Levobupivacaine (S75-R25) 0.25% and Ropivacaine 0.25% in sciatic-popliteal nerve block for postoperative analgesia in foot and ankle surgeries: a randomized and double-blind study	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-29	Departamento de cirurgia da Faculdade de Medicina da Universidade Federal do Rio	<NULL>	<NULL>	<NULL>	Patients undergoing elective foot and ankle surgery;  both sexes; aged between 18 and 70 years; with ASA I and II physical status, according to the classification of the American Society of Anesthesiologists;  body mass index (BMI) &lt; 30	Patients with peripheral neuropathies; declared allergies to the medications used; coagulation disorders; popliteal fossa infection; pregnant women; those who have undergone medial malleolus surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-9hhxqbs	Compare the cleaning effectiveness of teeth using Toothbrushes of Different Sizes and observe the presence of gingival fissures	Recruiting	Intervention	2026-03-26	<NULL>	<NULL>	9020	Efficacy of Toothbrushes with Different Head Sizes in biofilm removal and evaluation of supragingival and gingival fissure inflammatory parameters: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-04	Faculdade de Odontologia da Universidade Federal de Pelotas / FO-UFPel	<NULL>	<NULL>	<NULL>	Individuals of both sexes, Individuals aged 18-65; Individuals willing to participate in all experimental periods of the study; Individuals with at least 20 natural teeth present; must not be participating in any other study or research; patients diagnosed with gingivitis; gingivitis will be defined as at least 30% of bleeding on probing determined at the initial consultation; patients with a minimum mean plaque index of 1,0	"Dental students; smokers; Individuals with uncontrolled hyperglycemia; pregnant and lactating women;
individuals with carious lesions; individuals with root remnants in the mouth; individuals diagnosed with periodontitis; periodontitis defined as interproximal attachment loss (IAL) ≥ 2 mm in non-adjacent teeth associated with probing depth (PD) ≥ 4 mm and bleeding on probing (BS) + (Papapanou et al., 2018); Individuals wearing removable partial dentures (RPDs); Individuals wearing fixed orthodontic appliances;
Individuals who have used anti-inflammatories and/or corticosteroids within 3 months of the experimental phase; Individuals who have used antibiotics three months prior to the present study; Individuals who have received dental prophylaxis or periodontal treatment in the last three months; Individuals who require antibiotic prophylaxis prior to dental procedure"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-7ymcmxs	Is Exercise during Pregnancy and the Postpartum Period effective for women’s health and well-being?	Recruitment completed	Intervention	2026-03-26	<NULL>	<NULL>	9021	The Effectiveness of exercise on women&apos;s health and well-being during Pregnancy and the Postpartum	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-12	Universidad de Sevilla	<NULL>	<NULL>	<NULL>	healthy volunteers; women who are between 14 and 30 weeks pregnant; who attend a minimum of 20 classes during pregnancy; aged between 18 and 42; vaginal delivery	Caesarean section; abdominal surgery; respiratory conditions, chronic obstructive pulmonary disease, pneumonia, cystic fibrosis; any neurodegenerative disease; systemic diseases, arthritis and ankylosing spondylitis; metabolic diseases, diabetes mellitus; malignant neoplasms	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-7jr6cjg	Spirulina in women with obesityand sedentary lifestyle how it affects long-term health and metabolism	Recruitment completed	Intervention	2026-03-25	<NULL>	<NULL>	9009	Longitudinal study on the immunometabolic effect of continuous spirulina supplementation in sedentary and obese women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-26	Universidade de Cuiaba  Unic	<NULL>	<NULL>	<NULL>	Obese women (grades I, II, III); between 30 and 50 years old; who are not using weight-loss medication; do not have external nutritional monitoring; and do not engage in regular physical activity	Women outside the defined age range who are using weight-loss medication or under the nutritional supervision of another professional; and those who practice physical activity; men in any condition; also women with comorbidities such as neuropathies; acute deep vein thrombosis; psychiatric disorders and/or dementia without speech or comprehension of the English language; pregnant women; and those who refuse to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-3vpbtn2	Gingival Graft Surgery and Donor Site Healing: A Randomized Clinical Trial	Not yet recruiting	Intervention	2026-03-25	<NULL>	<NULL>	9010	Surgical techniques for gingival grafting and donor site regeneration strategies: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-30	Faculdade de Odontologia - Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Age between 18 and 60 years; both sexes; presence of isolated gingival recession ≥ 4 mm, classified as Miller Class I, II, or III or recession type 1 or 2 according to Cairo classification; systemically healthy patients with no contraindications for periodontal surgery; probing depth &lt; 3 mm at the involved sites; selected teeth free of restorations, caries, or non-carious cervical lesions	Smoking more than 10 cigarettes per day; uncontrolled diabetes mellitus; chronic or aggressive periodontitis; use of medications affecting bone metabolism; chronic upper respiratory tract infections; chronic use of anti-inflammatory drugs or antibiotics; bruxism; alcohol abuse or substance dependence; pregnancy or intention to become pregnant within one year; history of radiotherapy in the head and neck region; diseases affecting bone metabolism; extensive membrane rupture during the surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-10sb6573	Effects of physiotherapy on pain and mobility in individuals with temporomandibular dysfunction	Recruiting	Intervention	2026-03-25	<NULL>	<NULL>	9011	Effects of physiotherapeutic treatment on pain modulation and clinical variables in individuals with temporomandibular disorder	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Ciência da Saúde	<NULL>	<NULL>	<NULL>	adults aged 18 years or older; individuals of both sexes; participants recruited from the waiting list for physiotherapy care at the physical therapy teaching clinic of the federal university of paraíba; for the symptomatic group, individuals presenting signs and symptoms of temporomandibular disorders and scoring higher than 2 points on the temporomandibular disorder pain screening instrument (research diagnostic criteria for temporomandibular disorders – rdc/tmd); for the asymptomatic group, individuals without complaints of pain in the temporomandibular joint region and scoring 2 points or less on the temporomandibular disorder pain screening instrument (research diagnostic criteria for temporomandibular disorders – rdc/tmd); asymptomatic participants matched by sex and age with the symptomatic group, considering a maximum variation of three years; individuals who agree to participate in the study and sign the informed consent form	individuals diagnosed with inflammatory arthritis; participants with a history of fractures or dislocations in the facial or cervical regions; individuals with metabolic diseases that may interfere with study outcomes; participants who withdraw from the study after the beginning of the intervention; individuals who miss more than two physiotherapy sessions; participants who develop intercurrent clinical conditions that may compromise assessments or interfere with study results; individuals who present relevant adverse effects related to the intervention; participants who do not agree with or do not adhere to the proposed assessment and treatment procedures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-2vnz97m	How to choose the best oral health product: a practical study	Recruiting	Intervention	2026-03-25	<NULL>	<NULL>	9012	Efficacy of a Digital Guida on Oral Hygiene Products in Decision-Making: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-16	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Dentists and oral health professionals actively linked to a Primary Health Care Unit or Family Health Strategy in the listed municipalities; availability to read the guide and complete the pre- and post-test questionnaires during the study period; active enrollment in the last semester of the Dentistry course at the participating institutions; presence on the official class attendance list.	Exclusively administrative professionals without clinical practice; professionals on extended leave during the intervention window; students who have had prior formal contact with the specific guidelines tested in extracurricular activities that may bias their perception of knowledge and confidence.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-879qjjx	Influence of Dental Scaling on the adaptation of Complete Dentures	Not yet recruiting	Intervention	2026-03-25	<NULL>	<NULL>	9013	Influence of prior Supragingival Scaling on tissue healing and adaptation of Immediate Complete Dentures	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Indication for extraction of all teeth due to periodontal disease in the maxilla or mandible; Age between 30 and 70 years; Need for total rehabilitation with a prosthesis; Sufficient health conditions to undergo surgical procedure (ASA I and ASA II); Sufficient cognitive capacity to understand the procedures to be performed and the Informed Consent Form	Smokers who consume more than 20 cigarettes daily; Those using medications that alter bone metabolism; Pregnant and breastfeeding women; History of head and neck radiotherapy; Insufficient cognitive function to understand the research protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-997wcch	Exploring Food Selectivity in Children with and without ASD and the Impact of a Parental Guidance Program	Not yet recruiting	Intervention	2026-03-25	<NULL>	<NULL>	9014	Multicausal Investigation of Food Selectivity in children with and Without ASD and the Effects of a Parental Guidance Program	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Instituto Multidisciplinar em Saúde - Campus Anísio Teixeira	<NULL>	<NULL>	<NULL>	Children aged 3 to 10 years; with complaints of selective eating; with or without a diagnosis of ASD (Autism Spectrum Disorder); who present criteria for selective eating indicated by the Eating Behavior Assessment Scale; for inclusion in the group of children with ASD (Autism Spectrum Disorder), the child must have a professional diagnosis of ASD (Autism Spectrum Disorder)	Children under 3 or over 11 years of age; children with severe cognitive delay with a percentile lower than 10 on the intelligence test measured by the Columbia Mental Maturity Scale 3 or Raven&apos;s Colored Progressive Matrices; children with epilepsy; previously diagnosed genetic syndromes or with dysmorphisms indicating syndromes, by clinical evaluation and previous medical diagnosis; children with uncorrected vision and hearing problems, by clinical evaluation and previous medical diagnosis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-65kd9hb	Effect of a intensive training in improving the use of the legs of individuals with incomplete spinal cord injury	Not yet recruiting	Intervention	2026-03-24	<NULL>	<NULL>	9008	Effect of Rehabilitation based on Activity Constraint-Induced Therapy for people with Spinal Cord Injury (ReACIT-SCI) in improving the use of the lower extremities of individuals with incomplete Spinal Cord Injury	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade do Estado de Santa Catarina	<NULL>	<NULL>	<NULL>	To be eligible, participants must: have an incomplete motor spinal cord injury of any neurological level and any etiology; have a chronic spinal cord injury, i.e., more than six months since the injury, with no upper time limit; be between 18 and 50 years old; be able to walk at least ten meters, with or without a walking aid, but without assistance from others; have a walking speed between 0.20 m/s and 1.00 m/s; be available to perform at least 75% of the in-person protocol and homework assignments; and have the possibility and ability to cancel other interventions aimed at improving mobility during the study period.	Insufficient level of understanding and communication to complete the Lower Extremity Motor Activity Log without assistance in less than 30 minutes, as therapists will administer the instrument daily during the intervention and need to complete it within this pre-established time; and some musculoskeletal, cardiorespiratory, or neurological condition not associated with spinal cord injury that has a direct effect on independence for mobility activities.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-2zkf2w3	Use of hearing aids along with word recall training in elderly people with hearing loss: a randomized clinical trial	Recruitment completed	Intervention	2026-03-23	<NULL>	<NULL>	9005	Effect of hearing aid combined with verbal fluency training in older adults with presbycusis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-05	Universidade Federal das Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Older adults (aged 60 years or older) with a diagnosis of moderate to severe presbycusis (hearing thresholds between 35 dB and 80 dB); bilateral hearing aid users for no more than 3 months; residents of Caxias do Sul, Rio Grande do Sul, Brazil; provision of written informed consent agreeing to participate in the study	Previous experience with hearing aid use prior to the current fitting; non-residents of Caxias do Sul, Rio Grande do Sul, Brazil; refusal to provide written informed consent; failure to attend any of the assessment, intervention, or reassessment stages of the study; self-reported medical diagnosis of neurological conditions that may affect cognition, such as stroke, Alzheimer’s disease, dementia, or related disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-7b39zbh	Use of artificial intelligence to assist dentists in diagnosing dental caries in radiographs in primary health care	Not yet recruiting	Intervention	2026-03-23	<NULL>	<NULL>	9006	Impact of using an artificial intelligence system in the radiographic diagnosis of caries lesions by primary healthcare dentists in Governador Valadares: a randomized experimental study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-25	Universidade Federal de Juiz de Fora Campus Governador Valadares	<NULL>	<NULL>	<NULL>	Dentists working in Primary Health Care in the municipality of Governador Valadares, Minas Gerais	Primary healthcare dentists who perform administrative functions; who have a specialization in radiology, or who are pursuing a specialization in radiology	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-6pjdr2r	Use of semaglutide with metformin in weight loss and gut health of individuals with obesity: an open and randomized clinical trial	Recruiting	Intervention	2026-03-23	<NULL>	<NULL>	9007	Evaluation of the Use of Semaglutide Associated with Metformin on Weight Loss, Modulation of the Intestinal Microbiota, and Inflammatory Profile in Individuals with Obesity – Open Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-25	Faculdade de Ciências Médicas da Universidade Estadual de Campinas - UNICAMP	<NULL>	<NULL>	<NULL>	Adults aged 20 to 60 years; Of both sexes (female and male); With a Body Mass Index (BMI) between 29.0 and 44.0 kg/m²; Preferentially members of the UNICAMP community (where the study will be conducted); All participants must voluntarily sign the Informed Consent Form (ICF) before starting participation in the study, as well as the ICFs for different stages of the study with specific details regarding the procedures	Individuals with type 1 and type 2 diabetes;Individuals with obesity secondary to the use of medications and/or associated diseases (Cushing&apos;s syndrome, acromegaly, etc.);Individuals who, within 90 days prior to the start of the study, used GLP-1 receptor agonists, antibiotics, probiotics, or prebiotics; Individuals who have previously undergone surgical treatment for obesity;Individuals who are planning any treatment or intervention that may interfere with weight assessment (intragastric balloon);Individuals allergic to GLP-1 receptor agonists or any other excipient of semaglutide or Metformin XR;Individuals who, in the last 90 days, participated in any study related to obesity, diabetes, and microbiota and who used any medication, probiotic, prebiotic, or antibiotic;Individuals with untreated thyroid dysfunction;Individuals who have had major cardiovascular and/or cerebrovascular events in the last 180 days and/or heart failure;Individuals with severe gastrointestinal disease or inflammatory bowel disease;Individuals with moderate to severe depression or severe mental illness such as schizophrenia and bipolar disorder;Individuals with acute or chronic pancreatitis;Individuals with chronic kidney disease with a glomerular filtration rate (GFR) less than 30 mL/min/1.73m²;Individuals with liver cirrhosis; Individuals with active rheumatologic diseases;Individuals diagnosed with a malignant tumor in the last 5 years; Individuals with a diagnosed eating disorder (bulimia or binge eating)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-7smyv87	Comparison of muscle strength and discomfort during electrical stimulation in healthy individuals, using self-adhesive electrodes and carbon–silicone electrodes.	Data analysis completed	Intervention	2026-03-21	<NULL>	<NULL>	8980	Comparison of peak torque and discomfort during neuromuscular electrical stimulation in healthy individuals using self-adhesive and carbon-silicone electrodes.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-24	Universidade São Francisco - USF	<NULL>	<NULL>	<NULL>	Women; healthy; aged between 18 and 30; with no history of nerve injury and/or musculoskeletal disorders in the limbs to be tested, which could interfere with the results.	Individuals using continuous pain-inhibiting medication; individuals with cardiac pacemakers; women who are pregnant, in the postpartum period, or menstruating; volunteers who, during the familiarization stimulation, cannot tolerate at least one contraction induced at 50% of their maximum voluntary isometric contraction force	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:23
RBR-6n6wzsx	Study on the use of cannabidiol oil in the treatment of Major Depressive Disorder	Not yet recruiting	Intervention	2026-03-19	<NULL>	<NULL>	8996	Effects of full-spectrum cannabidiol oil on symptoms of Major Depressive Disorder: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Sociedade De Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Adult participants aged between eighteen and sixty nine years; residents of municipalities in the Greater Florianopolis region; previous diagnosis of Major Depressive Disorder confirmed according to the Diagnostic and Statistical Manual of Mental Disorders fifth edition text revision of the American Psychiatric Association; presence of a major depressive episode characterized by depressed mood and or loss of interest or pleasure for at least two weeks associated with additional symptoms compatible with the clinical diagnosis; current use of antidepressant medication for at least sixty days without satisfactory clinical response characterizing treatment resistant depression; voluntary agreement to participate in the study through signing the informed consent form	Use of cannabinoid substances natural or synthetic within thirty days prior to the beginning of the study; history of intolerance or adverse reaction to components of the Cannabis plant including confusion paranoia pruritus excessive somnolence vomiting diarrhea or seizures; women who are pregnant planning pregnancy or breastfeeding; presence of severe medical illness or clinical condition that may interfere with the evaluation of study outcomes; presence of decompensated psychiatric comorbidity including psychotic disorders severe personality disorders or active suicidal ideation; moderate or severe cognitive impairment that prevents adequate understanding of study assessment instrumentstivo moderado ou grave que impeça a adequada compreensão dos instrumentos de avaliação do estudo	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-3nk4685	Use of a dual-action gel to reduce pain caused by dental bleaching performed by the dentist	Recruiting	Intervention	2026-03-19	<NULL>	<NULL>	8997	Management of in-office bleaching-induced tooth sensitivity using a dual-action desensitizing agent: a randomized, triple-blind, split-mouth controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-03	Programa de Pós-Graduação em Ciências Odontológicas	<NULL>	<NULL>	<NULL>	Individuals aged between 18 and 50 years ; good general systemic and oral health status ; presence of at least six sound upper anterior teeth, without caries or restorations ; shade corresponding to A2 or darker on the canine, according to the Vita Classical scale ; no history of previous dental bleaching	Use of dental prostheses or orthodontic appliances ; presence of severe tooth staining due to tetracycline, fluorosis, trauma, or pulp necrosis ; pregnant or lactating women ; clinical history of bruxism, gingival recession, visible dentin exposure, or extensive cracks ; current or past systemic diseases affecting the stomach, heart, kidneys, or liver ; continuous use of anti-inflammatory and/or analgesic drugs ; history of allergy to codeine, calcium phosphate, or any component of the tested nanogel	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-3xf65s5	Evaluation of the pharmacist’s follow-up in the management of chronic pain	Not yet recruiting	Intervention	2026-03-19	<NULL>	<NULL>	8998	Effect of pharmacotherapeutic follow-up in the management of chronic pain: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Patients diagnosed with osteoarthritis, gout, systemic lupus erythematosus, rheumatoid arthritis, and fibromyalgia; patients of both sexes; aged 18 years or older; currently using prescribed pharmacological treatment for these conditions for at least one month.	Patients with severe psychiatric disorders; cancer; pregnant women; patients without access to the WhatsApp® application; patients currently participating in other clinical trials evaluating the same outcomes of this study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-2b7bz9n	Integrative community therapy: strengthening bonds and helping students adapt to university life	Recruitment completed	Intervention	2026-03-19	<NULL>	<NULL>	8999	The use of Integrative Community Therapy (ICT) in building interpersonal bonds and reducing harms resulting from the university adaptation process	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-18	Universidade Federal dos Vales do Jequitinhonha e Mucuri	<NULL>	<NULL>	<NULL>	To be a first-semester student, regardless of age and gender; to have participated in the initial meeting; and to have signed the Informed consent form	Incomplete completion of the study instruments; being in psychological or psychiatric treatment concurrent with the study; prior diagnosis of mental disorder; continuous use of psychotropic drugs; interfering clinical conditions; adherence of less than 95% to the meetings	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-2ynd9jr	Influence of Resistance Training on Balance, Strength, Muscle Thickness, Functional Autonomy, and Plasma Antioxidant Biomarkers in Older	Recruitment completed	Intervention	2026-03-19	<NULL>	<NULL>	9000	Influence of Resistance Training on Balance, Muscle and Morphological/Architectural Function, Functional Autonomy, and Plasma Antioxidant Biomarkers in Older	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade do Estado do Rio de Janeiro - UERJ	<NULL>	<NULL>	<NULL>	Older individuals who have been sedentary for at least 3 months; both genders; over 60 years of age.	Individuals who present any pathology that alters gait; evidence of coronary disease; heart disease; congestive heart failure; uncontrolled hypertension; chronic obstructive pulmonary disease; diabetes mellitus; renal failure; major orthopedic disability and smokers.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-66gbrkj	Use of Refix Technology gel with Calcium combined with Low-Level Laser Therapy in the treatment of Cervical Dentin Hypersensitivity: a randomized controlled clinical trial	Recruiting	Intervention	2026-03-19	<NULL>	<NULL>	9001	Gel with Refix Technology and Calcium associated with Low-Level Laser Therapy in the treatment of Cervical Dentin Hypersensitivity: a controlled and randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-15	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients aged 18 to 60 years will be included; in good general health; presenting at least one tooth with exposed vestibular cervical dentin associated with symptoms of cervical dentin hypersensitivity, confirmed by a positive response to a 2-second air jet applied with an air-water syringe. To be eligible, the patient must register a minimum score of 40 mm on a 100 mm Visual Analog Scale (VAS). Teeth with non-carious cervical lesions (NCCL) with dentin loss greater than 2 mm in depth, requiring restorative intervention associated with dentin hypersensitivity, will be included with the same inclusion criteria. Differential diagnosis will be performed to exclude other pathologies, and the vitality of all teeth will be verified before, after treatment, and during follow-up periods, using vertical and horizontal percussion tests, as well as periapical radiographs.	Teeth with evidence of pulpal pathology or loss of vitality; carious lesions; deficient restorations; premature contacts; enamel cracks; active periodontal disease; or tooth mobility greater than grade I will be excluded. Individuals presenting any of the following conditions will also be excluded: existing medical conditions; eating disorders (e.g., bulimia) or diets causing dental erosion and/or wear; history of adverse reactions to any oral hygiene products; use of daily medications that interfere with pain perception, including sedatives, tranquilizers, analgesics, anticonvulsants, and anti-inflammatory drugs within the last 72 hours; use of any desensitizing agents or dental bleaching within the last 3 months, or those who have undergone periodontal surgeries for root coverage within the last 12 months. Pregnant or lactating women will also be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-742f68t	Electrical Stimulation and Voice: Immediate Effects in Women with Voice Disorders	Data analysis completed	Intervention	2026-03-19	<NULL>	<NULL>	9002	Comparison of the immediate effects of low-frequency and modulated medium-frequency TENS electrical currents on the self-perception and vocal quality of dysphonic women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Women with an otorhinolaryngological diagnosis of behavioral dysphonia, aged between 18 and 50 years. For the non-dysphonic group, women with self-reported good health, without vocal complaints or alterations, aged between 18 and 50 years, will be included.	For both groups: pregnant women; individuals with self-reported health conditions such as cardiac, pulmonary, hearing, neurological, or psychiatric disorders, or a diagnosis of organic dysphonia; those who have previously undergone speech-language therapy for voice; and those who have previously received electrotherapy for any type of treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-3gvnwgm	Use of doxycycline to protect blood vessels in patients with circulatory shock	Recruiting	Intervention	2026-03-19	<NULL>	<NULL>	9003	Randomized, double-blind clinical trial on the use of Doxycycline for the preservation of the Endothelial Glycocalyx in Circulatory Shock	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-09	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Adult patients of both sexes; aged 18 years or older; diagnosis of circulatory shock defined by the need for vasopressors to maintain mean arterial pressure above 65 mmHg and serum lactate greater than 2 mg/dL; signed informed consent provided by the legal representative	Neoplastic disease; advanced liver failure; stage IV renal failure or receiving renal replacement therapy; type 1 diabetes mellitus; post–cardiac arrest; patients receiving exclusive palliative care; use of oral anticoagulation; pregnancy or possibility of pregnancy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-7gzhbqx	Potential effects of daily coffee intake on women with symptoms of Stress, Anxiety, and Depression	Not yet recruiting	Intervention	2026-03-19	<NULL>	<NULL>	9004	Potential effects of coffee consumption on symptoms of Stress, Anxiety, and Depression in Brazilian women: a translational mixed study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Saúde Pública da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Cisgender women; over the age of 18 will be included; with a Body Mass Index (BMI) between 18.5 and 29.9 kg/m²; with some level of stress, anxiety, or depression scored on the DASS-21 scale (between “mild” and “extremely severe”) referring to the week preceding the first eligibility interview; who have not been using psychoactive medications in the last eight weeks and who do not have an active diagnosis of psychiatric disorders	Women with a recent history (last six months) of diagnosed mental disorders and/or frequent use of psychiatric medications and stimulant supplements (sources of caffeine or similar) will be excluded; individuals with daily coffee consumption greater than 150 ml/day in the last 30 days; participants diagnosed with active gastric or duodenal ulcer, severe gastritis, symptomatic gastroesophageal reflux disease, or any other condition that prevents coffee consumption will also be excluded; pregnancy; lactation; menopause; simultaneous involvement in similar clinical studies	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-6ww3q3j	Evaluation of different time frames for prosthesis placement following dental implantation	Not yet recruiting	Intervention	2026-03-18	<NULL>	<NULL>	8993	Early loading in Implant Dentistry involving single prostheses: randomized controlled clinical study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Faculdade de Odontologia do Campus de Araçatuba - UNESP	<NULL>	<NULL>	<NULL>	Patients of both genders; over 18 years of age; with good oral hygiene; no systemic contraindications for oral surgical therapy; with missing teeth or teeth indicated for extraction due to root fracture, caries, endodontic injury, or periodontal disease; who have an indication for rehabilitation with single implants; and who have adequate bone volume for implant placement, as assessed by Cone Beam Computed Tomography (bone availability for implants of at least 8 mm in length and 3.3 mm in diameter and without fenestrations in any wall that cannot be circumvented during surgery)	"Totally edentulous patients; patients who use medication that contraindicates the installation of implants or may alter osseointegration; patients with uncontrolled underlying diseases; patients who do not have adequate bone volume for the installation of implants; post-extraction cases that require gap closure with biomaterial and/or the use of a membrane; 
pregnant or lactating women; and heavy smokers (more than 2 packs of cigarettes per day)"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-789gmdf	Evaluation of the efficacy of Naltrexone/Bupropion in patients with weight regain, or insufficient weight loss. after Stomach Reduction surgery	Recruitment completed	Intervention	2026-03-18	<NULL>	<NULL>	8994	Evaluation of the efficacy of Naltrexone/Bupropion in patients with Weight Regain, or Insufficient Weight Loss. after Bariatric Surgery: a Prospective study	<NULL>	4, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Irmandade da Santa Casa de Misericórdia de São Paulo	<NULL>	<NULL>	<NULL>	Patients who underwent bariatric surgery at least 18 months earlier and experienced weight regain (at least 10 kg or a 5-point increase in body mass index), or insufficient weight loss (less than 50% of excess weight loss).	Exclusion criteria include pregnancy; breastfeeding; and the use of medications with known interactions with naltrexone or bupropion (ticlopidine; clopidogrel; ritonavir; lopinavir; efavirenz; carbamazepine; phenobarbital; and phenytoin); prior use of bupropion or naltrexone; use of anti-obesity medications; bipolar affective disorder; previous cardiovascular events	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-3zyhygn	Effects of intense training on memory and attention in people with High Blood Pressure and cognitive difficulties	Not yet recruiting	Intervention	2026-03-18	<NULL>	<NULL>	8995	Effect of high-intensity interval training on cognitive performance in hypertensive individuals with cognitive impairment: a blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-14	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Individuals of both sexes; age between forty-five and sixty-four years; diagnosis of early-onset systemic arterial hypertension before fifty-five years of age; undergoing treatment for systemic arterial hypertension; presence of mild to moderate cognitive impairment assessed by the Montreal Cognitive Assessment	Individuals with Systemic arterial hypertension stage two, defined by systolic blood pressure equal to or higher than one hundred and sixty millimeters of mercury and or diastolic blood pressure equal to or higher than one hundred millimeters of mercury; presence of severe cognitive impairment or diagnosis of dementia; speech impairment that limits or prevents communication; diagnosis of severe untreated mental disorder; history of severe cardiac diseases; abnormal twelve-lead electrocardiogram at rest or during physical exertion; contraindication to physical exercise indicated by a cardiologist; presence of secondary hypertension; evidence of target organ dysfunction, including kidneys and retina; grade two obesity; presence of severe cardiometabolic diseases; current participation in a structured physical training program; female participants with premature menopause, before forty years of age, or induced menopause	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-378kp32	Helping Doctors and Patients Work Together to Improve Lupus Care: A Randomized Study	Recruiting	Intervention	2026-03-17	<NULL>	<NULL>	8989	Bridging Patient and Physician Perceptions to Improve Outcomes in Systemic Lupus Erythematosus: A Randomized Controlled Trial Using Value-Based Care	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-28	Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP)	<NULL>	<NULL>	<NULL>	Diagnosis of systemic lupus erythematosus according to the Systemic Lupus International Collaborating Clinics (SLICC) criteria; age 18 years or older; participants of both genders; ability to read understand and sign the informed consent form; current or recurrent episode of disease activity assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI ≥ 4) within the last two months prompting a clinical decision to modify treatment at study initiation	Overlap with other autoimmune diseases; illiteracy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-108s9fg4	Strengthening the inspiratory muscles in obstructive sleep apnea	Not yet recruiting	Intervention	2026-03-17	<NULL>	<NULL>	8990	Inspiratory muscle training in individuals with obstructive sleep apnea	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-15	Escola de Educação Física da Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Age over 18 years;men or women;diagnosis of obstructive sleep apnea;failure to adapt to continuous positive airway pressure therapy, low adherence to continuous positive airway pressure therapy (use for less than 4 hours on 70 percent of nights), or referral for conservative treatments (use of an intraoral appliance and orofacial myofunctional therapy);signing of the Informed Consent Form	Contraindications to inspiratory muscle training, such as: recent surgery (thoracic, abdominal, brain, ear, nose, and throat);pneumothorax;hemoptysis;pulmonary embolism;acute diarrhea or stress incontinence;dementia or any other condition in which the patient is unable to understand the test; patient discomfort; risk of infection;glaucoma or retinal detachment;abdominal hernia;recent acute myocardial infarction or unstable angina;severe arterial hypertension (systolic blood pressure greater than 200 millimeters of mercury and diastolic blood pressure greater than 120 millimeters of mercury);aortic aneurysm;neurological diseases;middle ear disorders;as well as inability to understand and/or perform the tests proposed for the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-53d4b2y	How to develop effective and affordable functional products for the population	Terminated	Intervention	2026-03-17	<NULL>	<NULL>	8991	Alternatives for developing functional products with improved efficacy and low cost	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de Lavras	<NULL>	<NULL>	<NULL>	People aged 18 to 59 years; both sexes; residents of the study city; obesity.	Chronic inflammatory diseases; smoking; severe hypertension; alternative diets (vegan and macrobiotic); daily consumption of eight or more servings of fruit or eight or more servings of fresh vegetables; excessive alcohol intake (more than thirty grams of ethanol per day); daily physical activity; consumption of more than one liter of coffee per day; pregnancy; daily use of anti-inflammatory medications, such as aspirin, or mineral and vitamin supplements; use of medications for depression and appetite suppressants; and incomplete elementary education	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-4bj9kmt	Safety of performingbreathing exercises together with stationary cycling exercise in people whit heart failure	Not yet recruiting	Intervention	2026-03-17	<NULL>	<NULL>	8992	Safety of Inspiratory Muscle Training Concurrent with Aerobic Training in patients with heart failure	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Instituto Nacional de Cardiologia - INC	<NULL>	<NULL>	<NULL>	Patients of both sexes; diagnosis of heart failure with reduced ejection fraction lower than forty percent and functional class II or III according to the New York Heart Association (NYHA); participants of the cardiac rehabilitation program at the Instituto Nacional de Cardiologia with regular participation at least twice per week for at least three months	Inability to understand the commands required to perform inspiratory muscle training or aerobic exercise; physical limitation preventing the performance of inspiratory muscle training or aerobic exercise; presence of signs of infection at the time of recruitment or intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-4fxmhs7	Effects of Caffeine and Capsaicin on Performance of Brazilian Jiu-Jitsu Athletes	Recruiting	Intervention	2026-03-16	<NULL>	<NULL>	8981	Investigation into the possible acute effects of caffeine and capsaicin supplementation on performance and psychophysiological responses in Brazilian jiu-jitsu athletes	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-17	Escola de Educação Física da Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Male Brazilian Jiu-Jitsu athletes. Age between 18 and 35 years. Minimum blue belt rank. Regular practice of Brazilian Jiu-Jitsu training for at least 12 months. Absence of self-reported musculoskeletal injuries in the upper limbs in the previous six months. Agreement to abstain from consuming products containing caffeine and other ergogenic supplements at least 48 hours before each experimental session. Voluntary participation through signing the Informed Consent Form.	History of cardiovascular, metabolic, neurological, or gastrointestinal diseases. Use of medications or supplements that may interfere with physical performance or cardiovascular responses. Hypersensitivity or intolerance to caffeine or capsaicin. Smoking. Alcohol consumption in the 24 hours prior to experimental sessions. Failure to comply with the pre-test recommendations established by the experimental protocol. Occurrence of adverse effects related to supplementation during experimental sessions. Voluntary withdrawal of the participant at any stage of the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-283y5bp	Assessment of non ablative Radiofrequency in menopausal women with genitals and urinary syntoms	Recruiting	Intervention	2026-03-16	<NULL>	<NULL>	8982	Assessment of non ablative Radiofrenquency in peri menopausal and posmenopausal women with Genitourinary Syndrome	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Fundação José Bonifácio Lafayette de Andrada	<NULL>	<NULL>	<NULL>	Menopausal women (aged 50-70 years); dryness; dyspareunia; mild urinary incontinence.	Active vaginal infections;chronic vaginal infections;recent use of vaginal regenerative therapies; patients with contraindications to energy use;active cancer; active tuberculosis;pregnant women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3ysvs5p	How technology aid dental students in detecting cavities: a practical study	Not yet recruiting	Intervention	2026-03-16	<NULL>	<NULL>	8983	Impact of artificial intelligence on the radiographic diagnostic ability of dental caries lesions by dentistry students: a randomized experimental trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-16	Universidade Federal de Juiz de Fora (UFJF)	<NULL>	<NULL>	<NULL>	Dental students from the Federal University of Juiz de Fora Governador Valadares campus, regardless of gender, social class, or religious belief; Extracted teeth permanent molars and premolars extracted for periodontal reasons, sound and/or with caries lesions in enamel and dentin	Students those who have not passed the course Dental Radiology I or Basic Dental Radiology; Extracted teeth with coronal restorations, endodontic access, coronal fractures, or partial or total coronal destruction	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-5kd6vg5	Light Belt Therapy to Help Patients Breathe on Their Own and Prevent Muscle Weakness in the Intensive Care Unit	Recruiting	Intervention	2026-03-16	<NULL>	<NULL>	8984	Photobiomodulation Therapy With LEDs Belt in Ventilator Weaning of Patients in the Prevention of Intensive Care Unit-Acquired Weakness (ICUAW)	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Anhembi Morumbi São José dos Campos	<NULL>	<NULL>	<NULL>	Volunteers with a clinical diagnosis of pneumonia; undergoing conventional respiratory physiotherapy treatment; using Invasive Mechanical Ventilation (IMV), regardless of mode and ventilatory parameters; receiving medication treatment according to previously adopted clinical protocols; aged over 18 years; of both sexes; and who agree to participate in the study by signing the Informed Consent Form (ICF).	Patients in spontaneous breathing (without artificial airway); patients under continuous sedation; or those presenting a lower level of consciousness within 24 hours after weaning, assessed using the Richmond Agitation-Sedation Scale (RASS), will not be included.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-2ztrfxj	Study on the results and costs of different implant treatments for tooth replacement in young patients through the Brazilian Unified Health System	Recruiting	Observational	2026-03-16	<NULL>	<NULL>	8985	Rehabilitation protocols with implants for anterior single tooth loss in young patients in the context of the public health: analysis of effectiveness and cost-effectiveness associated with a prospective cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-30	Faculdade de Odontologia, Universidade Federal de Goias	<NULL>	<NULL>	<NULL>	Age greater than 18 and less than or equal to 60 years. Both sexes. Patients with a single missing anterior tooth in the maxilla or an anterior tooth indicated for extraction, clinically suitable for surgical planning. Willingness to participate and to sign the informed consent form. Healed anterior edentulous ridge with at least 8 weeks since extraction, or tooth indicated for extraction due to fracture, non-restorable coronal destruction, or localized periodontal problem. Minimum ridge dimensions of 5.4 millimeters in width and 12 millimeters in height in the anterior maxilla, allowing placement of regular or narrow diameter implants with a minimum length of 10 millimeters	Inability to perform adequate oral hygiene or postoperative care. Inability to provide written informed consent or to comply with the study protocol. Any contraindication for oral surgery, including but not limited to uncontrolled diabetes, immunosuppression, radiation therapy, chemotherapy, or use of antiresorptive medications such as bisphosphonates. Presence of multiple posterior edentulous spaces requiring extensive oral rehabilitation. Heavy smoking habit with consumption greater than 20 cigarettes per day	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-8hvb4pj	Randomized controlled clinical trial comparing joint infiltration of bone marrow aspirate (BMA) and corticosteroid in patients with knee osteoarthritis	Terminated	Intervention	2026-03-16	<NULL>	<NULL>	8986	Randomized controlled comparative study between Joint Infiltration of Bone Marrow Aspirate (BMA) and Corticosteroid in patients with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-15	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Age between 40 and 80 years; both genders; osteoarthritis in one or both knees grading 2 or 3 according to the Kellgren and Lawrence score and fulfilling the American College of Rheumatology criteria for knee osteoarthritis; report pain above 3 points on the Visual Analogue Scale in one or both knees	Use of analgesics, nonsteroidal anti-inflammatory drugs and muscle relaxants less than one week before the start of the study; Use of slow-acting drugs for osteoarthritis started less than 8 weeks before the procedure; Corticosteroid infiltration or hyaluronic acid infiltration in the six months preceding the procedure; Body Mass Index greater than kilograms per square meter; Presence of other types of arthropathies such as rheumatoid arthritis, diffuse connective tissue diseases, microcrystalline arthropathies, spondyloarthropathies and infectious arthropathies; Symptomatic osteoarthritis of the hips and feet; blood dyscrasia or use of anticoagulants, presence of other diseases such as severe depression, decompensated diabetes, coagulopathies, decompensated cardiovascular disease, infection, immunosuppression, symptomatic vascular disease of the lower limbs, neurological diseases, neoplasia or any other conditions that, in the doctor&apos;s assessment, may compromise the procedure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-929vxkw	Mobile game to improve toothbrushing in children	Recruitment completed	Intervention	2026-03-16	<NULL>	<NULL>	8987	Gamification as an auxiliary method for children&apos;s oral hygiene	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Children in good general health; aged 6 to 8 years; from both genders	Children with intellectual, physical, or developmental difficulties that prevent proper toothbrushing; children without access to a smartphone	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-5t2kjj4	Effect of vitamin C on periodontal treatment of diabetes	Recruitment completed	Intervention	2026-03-16	<NULL>	<NULL>	8988	Effect of ascorbic acid supplementation on periodontal treatment of individuals with type II diabetes: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-05	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Patients with type II diabetes mellitus; patients with periodontitis stage II or III; minimum age of 30 years; at least fourteen teeth in the mouth	Individuals with diseases with alteration in the immune system; smokers; individuals who make use of dietary supplementation; individuals who need a diet with low sodium concentrations; pregnant and lactating women; individuals who have undergone periodontal treatment in the last 6 months; individuals with implants and peri-implant diseases; individuals who have undergone antimicrobial and anti-inflammatory therapy in the last 3 months; Individuals who have renal dysfunction; individuals who use anticoagulants and antiplatelet agents; individuals who changed their diabetes medication during the study period; individuals using insulin; Individuals with glycated hemoglobin above 9%; individuals with fasting blood glucose above 250mg/dl	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-6hq5qpr	Clinical study to evaluate the safety and efficacy of a transcranial electrical stimulation protocol in the treatment of tinnitus.	Recruiting	Intervention	2026-03-15	<NULL>	<NULL>	8978	Multicenter, randomized, controlled, phase 2 and 3 clinical trial to evaluate the safety and efficacy of a transcranial electrical stimulation protocol in the treatment of tinnitus.	<NULL>	2-3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal de Minas Gerais - Faculdade de Medicina	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; Individuals with hearing loss and a recommendation for hearing aids who complain of tinnitus; Individuals with normal hearing who complain of tinnitus.	Individuals under 18 years of age or incapacitated; Neurological or neurodegenerative disease that interferes with cognitive function; Use of a pacemaker or any other electronic device that may be affected by the use of TEE	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-9mfchtj	The right test, for the right patient, at the right time: using clinical and cerebrospinal fluid data to identify central nervous system infections	Not yet recruiting	Intervention	2026-03-15	<NULL>	<NULL>	8979	Prediction of infectious agents in the Biofire® FilmArray bioMérieux Meningitis/Encephalitis panel based on clinical syndrome and cerebrospinal fluid parameters: a diagnostic stewardship proposal	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-16	Irmandade da Santa Casa de Misericordia de Porto Alegre - ISCMPA	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older, of any gender, who consent to participate in the study by signing an informed consent form will be included. To participate in the study, patients must present at least two of the following symptoms: fever, lethargy, altered level of consciousness, seizure, acute focal deficit, signs of meningeal irritation, or headache, all with onset within the last 30 days and, obligatorily, pleocytosis (at least 5 leukocytes in the cerebrospinal fluid) For the control group, patients aged 18 years or older, of any gender, who were hospitalized in the SCPA with clinical syndrome of central nervous system infection with confirmatory diagnosis by cerebrospinal fluid analysis in the last four years will be included. Only patients with at least 5 cells in the cerebrospinal fluid will be included	Patients who do not sign the informed consent form, patients with clinical manifestations lasting more than 30 days, patients under 18 years of age, as well as patients who have undergone neurosurgery in the last 30 days, will be excluded. In the control group, patients who have undergone neurosurgery in the 30 days prior to the onset of symptoms will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3jdsxsw	Transcranial Eectrical Stimulation, physical exercise, and craving in smokers	Data analysis completed	Intervention	2026-03-13	<NULL>	<NULL>	8974	Effects of Transcranial Direct Current Stimulation on craving in the prefrontal cortex before, during, and after physical exercise in smokers	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-03-14	Instituto de Ciências Biológicas e da Saúde da Universidade Federal de Alagoas	<NULL>	<NULL>	<NULL>	Age between 18 and 60 years; both sexes; being in stable clinical condition, without chronic obstructive pulmonary disease and without the need for hospital care; being on a waiting list for smoking cessation treatment centers in the city of Maceió, Brazil; intention to quit smoking; not participating in any type of smoking cessation treatment	Presence of chronic obstructive pulmonary disease; need for hospital care; unstable clinical conditions that prevent safe participation in aerobic exercise or transcranial direct current stimulation; current participation in any smoking cessation treatment; inability to understand or sign the Informed Consent Form; refusal to participate in the study or to continue at any stage of the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3hvhpbg	Use of Back Support Equipment in workers who have had Low Back Pain for more than 6 months	Recruiting	Intervention	2026-03-13	<NULL>	<NULL>	8975	Impact of Using Passive Exoskeleton on workers with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Hospital Universitário da Universidade Federal de Juiz de Fora	<NULL>	<NULL>	<NULL>	Workers of both sexes; aged between 18 and 65 years; affiliated with the University Hospital of the Federal University of Juiz de Fora; identified and monitored by the Occupational Health sector; presenting nonspecific chronic low back pain lasting more than six months; able to perform their usual work activities at the time of the research; voluntarily agreeing to participate in the study.	Volunteers with specific musculoskeletal conditions of the spine; individuals with neurological or respiratory diseases that limit physical function; those who do not have the clinical conditions to undergo the proposed assessments.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-6m954m4	From San Francisco to Rio: new approaches to HIV prevention for young men who have sex with men (Conectad@s Study)	Data analysis completed	Intervention	2026-03-13	<NULL>	<NULL>	8976	Collaborative research between San Francisco and Rio de Janeiro on HIV prevalence, risk, and biomedical prevention interventions among young men who have sex with men	<NULL>	4, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-01	Instituto Nacional de Infectologia Evandro Chagas - INI / FIOCRUZ	<NULL>	<NULL>	<NULL>	Male sex assigned at birth and male or non-binary gender identity or female sex assigned at birth and male gender identity; sex with men; age between 18 and 24 years; resident of the metropolitan region of Rio de Janeiro; with the intention of remaining in the region during the study; possession of a referral coupon (physical or electronic) from an eligible partner	Not agreeing to receive text messages; not owning a cell phone	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-6mnr6jb	Impact of Rapid Maxillary Expansion with Orthodontic Appliance on Oral Microbiome and Inflammation	Recruiting	Intervention	2026-03-13	<NULL>	<NULL>	8977	Effects of Rapid Maxillary Expansion with dental anchorage using orthodontic bands and gun bases and the impact on the oral microbiome and inflammatory intervals	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Volunteers aged 6 to 11 years with a clinical diagnosis of unilateral or bilateral posterior crossbite and/or maxillary atresia; Class I or Class II dental malocclusion; first or intertransitional period of mixed dentition; absence of extensive caries lesions and periodontal disease, good general and oral health; absence of previous orthodontic treatment	Volunteers with conditions that compromise oral health at the time of the initial evaluation; with systemic diseases or general health conditions that may interfere with treatment or clinical evaluations; with a history of previous orthodontic treatment; with craniofacial anomalies, genetic syndromes, or cleft lip and palate; continuous or recent use of medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-5j7m4gk	Comparison between aerial silk and artistic gymnastics in the physical development of children	Recruitment completed	Intervention	2026-03-12	<NULL>	<NULL>	8969	Feasibility of aerial silk intervention on physical performance and movement function in children: a blinded, non-randomized controlled trial	<NULL>	n/a, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Faculdade de Educação Física e Fisioterapia	<NULL>	<NULL>	<NULL>	Age between 7 and 14 years old; Be duly enrolled in the aerial silks and/or artistic gymnastics classes linked to Dance program, circus activities and gymnastics; Have a minimum attendance of 90% in their respective classes.	Participants who present with any musculoskeletal injury during the evaluation period, who have any medical contraindication, or who have not completed all stages of the evaluation will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-749vzfz	Comparison of the use of Mannitol vs Albumin in preventing the fall in Blood Pressure in patients with renal problems undergoing Prolonged Hemodialysis: a randomized controlled clinical trial	Recruiting	Intervention	2026-03-12	<NULL>	<NULL>	8970	Evaluation of the use of Mannitol and Albumin in the prevention of intradialytic hypotension in patients with Acute Kidney Injury undergoing Prolonged Hemodialysis: a randomized clinical trial	<NULL>	4, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Departamento de Suporte às Unidades de Saúde	<NULL>	<NULL>	<NULL>	Patients admitted to the Intensive Care Units (ICU) of the Hospital das Clínicas of the Faculty of Medicine of Botucatu; over 18 years of age; with Acute Kidney Injury associated with sepsis; in acute renal support therapy undergoing Hemodialysis; using norepinephrine at a dose of 0.2 to 0.6 ucg/kg/min and being monitored by the Acute Kidney Injury group of the nephrology service	Patients undergoing chronic renal replacement therapy (Chronic Kidney Disease dialysis and kidney transplant) and treated with less than two prolonged hemodialysis sessions will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-2db2syn	Ear Acupuncture for Quitting Smoking and Stress Relief: a clinical study	Not yet recruiting	Intervention	2026-03-12	<NULL>	<NULL>	8971	Auricular Acupuncture for Smoking Reduction/Cessation and Emotional Disorders in smokers	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal de Viçosa	<NULL>	<NULL>	<NULL>	Individuals who consume at least one cigarette daily at the time of data collection; present preserved cognitive function; exhibit moderate to high levels of anxiety, stress, and/or depression (Depression, Anxiety, and Stress Scale — DASS-21) and fatigue (Fatigue Assessment Scale — FAS), or poor sleep quality (Pittsburgh Sleep Quality Index — PSQI); are residents of the municipalities or members of the university community in Viçosa; have time availability for evaluations and treatment sessions; agree to be randomly allocated to the study groups; of both genders; and are aged 18 years or older	Ear piercings, except in the earlobe; history of allergy to metal or microporous tape; history of photosensitivity; presence of lesions, inflammation, deformity, or tattoos on the ear; history of skin cancer in the head and neck region; use of hearing aids; use of chemical peels (retinoic acid, retinol, Vitanol-A, tretinoin, isotretinoin) and/or Roaccutane® (Isotretinoin) within six months prior to the start of treatment, due to their photosensitizing properties; immunocompromised individuals (e.g., undergoing cancer treatment or using immunosuppressants); epilepsy; use of a cardiac pacemaker; pregnant or lactating women, or those planning to become pregnant during the study period; rejection of or fear of receiving the technique; and undergoing any other concomitant energetic therapy during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-4z5ndwm	Effects of breathing exercises and vocal training on the voices of amateur evangelical singers	Data analysis completed	Intervention	2026-03-12	<NULL>	<NULL>	8972	Effects of Vocal Training using voiced oral high-frequency oscillation with a respiratory device and Vocal Function Exercises in amateur evangelical singers	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Departamento de Fonoaudiologia da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Be between 18 and 45 years of age; have been singing in an evangelical church for at least one year; report good general health; both sexes.	Individuals with vocal complaints or vocal alterations identified during prior vocal screening; singers with cardiac or pulmonary conditions; smokers; self-reported hearing loss; neurological or psychiatric disorders; and scores higher than five on the Vocal Disorder Screening Index protocol.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-4xz3q8w	Laser surgery or extracorporeal lithotripsy: which is the best for quality of life?	Data analysis completed	Intervention	2026-03-12	<NULL>	<NULL>	8973	Assessment of the impact on the quality of life of patients undergoing Ureteroscopy with Holmium laser compared to Extracorporeal shock wave lithotripsy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-11	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Symptomatic adults; over 18 years of age; ureterolithiasis confirmed by CT scan; stone`s maximum diameter between 5 and 20 millimeters	other urological conditions; pelvic pain syndrome; using anticholinergics; alpha-blockers; calcium channel antagonists; phosphodiesterase type 5 inhibitors; under 18 years of age; illiterate people; psychiatric disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-10dq3wsm	Video about Self-care guidelines for Feet for People with Diabetes	Not yet recruiting	Intervention	2026-03-11	<NULL>	<NULL>	8964	Webcast on Foot Self-Care for People with Diabetes: Multimethod Study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-08	Fundação Universidade Estadual do Ceará	<NULL>	<NULL>	<NULL>	To be 18 years of age or older. To have a medical diagnosis of diabetes for at least six months. To be under regular follow-up at a Primary Health Care Unit (PHCU). To have or not have foot injuries. To have access to a landline or mobile phone	Those who do not have 20 to 30 minutes available to watch the video. those who answer the data collection instrument incompletely. those with visual or auditory impairment. cognitive impairment or any condition attested in their medical record that prevents concentration and viewing of the webcast. those who did not answer calls after four consecutive attempts. as well as those who changed their phone number during the course of the study were excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-10d9ks6b	Salivary, psychosocial, and dental assessment of transgender individuals in the Paraíba Valley region (São Paulo)	Recruiting	Observational	2026-03-11	<NULL>	<NULL>	8965	Assessment of saliva, oral health and mental health in a transgender population of a region in São Paulo state.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Instituto de Ciência e Tecnologia de São José dos Campos - UNESP	<NULL>	<NULL>	<NULL>	Transgender women (WTrans) Group: self-identified transgender women, undergoing gender transition and who at the time of data collection may or may not be undergoing hormone therapy; Transgender men (MTrans) Group: self-identified transgender men, undergoing gender transition and who at the time of data collection may or may not be undergoing hormone therapy; Cisgender women (MCis) Group: self-identified cisgender women; Cisgender men (HCis) Group: self-identified cisgender men; Aged 18 years or older; Availability to participate in the research	Individuals under 18 years of age; Inability to provide signed consent to participate in the research; Individuals with systemic conditions that may interfere with the research results, at the researchers&apos; discretion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-6pfv9fb	Health Education and Exercise Program for Hip Flexibility or Leg Strengthening in people with Knee Osteoarthritis	Not yet recruiting	Intervention	2026-03-11	<NULL>	<NULL>	8966	Protocol for a Feasibility Study of a Randomized Clinical Trial comparing a Health Education Program and Hip Flexibility Exercises versus a Lower Limb Strengthening Program in individuals with Knee osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-12	Departamento de Fisioterapia	<NULL>	<NULL>	<NULL>	Individuals aged between 40 and 80 years, of both sexes; report of knee pain lasting longer than six months; pain intensity equal to or greater than 4 on a 0 to 10 numeric pain rating scale; diagnosis of knee osteoarthritis confirmed by radiography and classified as grades II, III, or IV according to the Kellgren and Lawrence classification; availability to undergo bilateral knee radiographs	Presence of uncontrolled cardiovascular diseases; medical report contraindicating moderate-intensity physical exercise; cognitive impairment preventing understanding of assessment protocols; diagnosis of fibromyalgia or rheumatoid arthritis; body mass index equal to or greater than 30 kg/m²; participation in exercise under medical prescription; regular physical activity more than twice per week in the last six months; continuous walking longer than 30 minutes daily; diagnosis of hip osteoarthritis; presence of ligament injuries or tendinopathies in lower limbs; history of knee joint surgery; corticosteroid injection in the knee or hip within the last six months; report of pain in the hip, ankle, foot, or lumbar spine with intensity greater than knee pain	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-4mccfgk	Improving access to Leishmaniasis treatment for women of childbearing age	Recruiting	Observational	2026-03-11	<NULL>	<NULL>	8967	Exploring gender-inclusive approaches to improve access to Leishmaniasis treatment for women of reproductive age in southern Bahia, Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-22	Centro de Ciências da Saúde - Universidade Federal do Recôncavo da Bahia	<NULL>	<NULL>	<NULL>	For interview using a quantitative approach (multiple-choice questionnaire) and qualitative approach (in-depth interview): people who identify as women; aged between 15 and 49 years; residing in endemic areas covered by selected primary health care units in Southern Bahia, Brazil; regardless of contraceptive use and/or pregnancy status, definitive sterilization or biological sex. For focus group discussions: community health workers; men and women; residing or working in the region and willing to contribute to the topic	Individuals who in the opinion of their treating physician (or the investigator if clinically qualified) are not clinically fit to participate	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-6vnpb2s	Chronobiological signatures and melatonin interventions in Autism Spectrum Disorder - ASD: sleep, inflammation, and sensory processing	Recruiting	Intervention	2026-03-11	<NULL>	<NULL>	8968	Changes in sleep–wake rhythm and behavior in Autism	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Individuals aged between 4 and 18 years with a neurological and/or psychiatric diagnosis of Autism Spectrum Disorder (ASD), established according to the DSM-5-TR criteria	Not using beta-blockers or other medications that affect the synthesis and release pathways of melatonin; Not using melatonin.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-10qwh849	Graft derived from the patient’s own blood to enhance the healing of complex wounds.	Not yet recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8959	Autologous Fibrin Matrix Therapy in the Treatment of Individuals with Complex Wounds.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-09	Centro de Ciências da Saúde - Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Be over 18 years of age; regardless of gender; have a medical diagnosis of Diabetes Mellitus with a foot ulcer or lesion resulting from foot amputation related to Diabetes Mellitus; not be undergoing treatment with Autologous Leukocyte Platelet Fibrin Matrix; be available to attend the health service once a week	Pregnancy; lesions suspected of being malignant; significant anemia; wound with active bleeding; continuous use of anticoagulant medication; Ankle Brachial Index values ​​indicating severe ischemia; active infection; antibiotic use in the last month; chronic kidney disease; blood borne diseases; ulcers larger than 49 cm2; individuals with any type of reported allergy to the products of the therapies used in treatment (dressings/wound dressings)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-7dv562m	Effect of a Personalized Dietary Intervention on the Recovery of Children after Tonsillectomy and Adenoidectomy	Not yet recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8960	Impact of a Personalized Dietary Intervention on the Recovery of Children After Adenotonsillectomy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-15	Centro Integrado de Saúde Amaury de Medeiros - CISAM/UPE	<NULL>	<NULL>	<NULL>	Children of both sexes; age between five and ten years; confirmed medical indication for adenotonsillectomy due to obstructive sleep apnea, recurrent upper airway infections or other conditions associated with hypertrophy of the tonsils and adenoids, including mouth breathing syndrome; nutritional status classified as eutrophic, mild undernutrition or overweight according to body mass index for age expressed as Z score; preserved functional capacity; respiratory function within normal parameters for age, except for alterations related to tonsil and adenoid hypertrophy; legal guardians committed to adherence to the intervention protocol and participation in follow-up assessments; written informed consent signed by legal guardians	Hemodynamic instability; presence of chronic respiratory diseases in exacerbation, including asthma, cystic fibrosis or chronic bronchitis; acute respiratory infection within thirty days prior to the intervention, including pneumonia or bronchiolitis; congenital or acquired heart diseases; metabolic disorders such as type one or type two diabetes mellitus and hypothyroidism; regular use of corticosteroids or continuous use of bronchodilator medication; severe undernutrition or morbid obesity; previous specific nutritional follow-up; occurrence of severe complications during or after adenotonsillectomy, including hemorrhage or severe infections; need for surgical reintervention or prolonged mechanical ventilation; absence of informed consent from legal guardians	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3s3dkp3	The effect of Haloperidol on the survival of patients with severe infection	Not yet recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8961	Effects of Haloperidol on mortality in septic shock: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	The inclusion criteria will be individuals over 18 years of age, of both sexes, admitted with a diagnosis of septic shock and on mechanical ventilation (MV) to the Intensive Care Unit of the Hospital das Clínicas of the Faculty of Medicine of Botucatu (HC/FMB) between March 2026 and February 2028	Pregnant women, patients with brain death or in palliative care, those with other types of shock (cardiogenic, hemorrhagic), those with a prolonged QTc interval on the electrocardiogram (greater than or equal to 450 ms for men and greater than or equal to 470 ms for women), as well as those whose legal representative/family member does not consent to participation by signing the Informed Consent Form (ICF), will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:14
RBR-3wq9zxw	Dental bleaching in patients with restored non-carious cervical lesions.	Recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8962	Tooth sensitivity and bleaching efficacy in patients with restored non-carious cervical lesions: a non-randomized clinical trial	<NULL>	4, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Tuiuti do Paraná	<NULL>	<NULL>	<NULL>	Age equal to or greater than 18 years; good systemic and oral health; presence of the upper right canine with shade A2 or darker according to the Vita Classical shade guide; absence of restorations, cracks, or structural alterations in the anterior teeth for inclusion in the control group with sound teeth; presence of at least one non carious cervical lesion restored with composite resin in the anterior teeth for inclusion in the experimental group, with the restoration classified as good or excellent according to the World Dental Federation FDI criteria.	Presence of periodontal disease, carious lesions, visible cracks, fractures, previous endodontic treatment, or extensive restorations in the anterior teeth; use of orthodontic appliances or dental prostheses; severe intrinsic discolorations such as tetracycline staining, fluorosis, or grayish tooth discoloration; previous history of dental bleaching; presence of conditions associated with pre-existing sensitivity such as gingival recession, dentin exposure, or parafunctional habits such as bruxism; pregnancy or lactation; smoking habit; regular use of analgesic or anti-inflammatory medications.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-3m74jj8	How lifestyle changes can improve health and performance in healthcare professionals	Not yet recruiting	Intervention	2026-03-10	<NULL>	<NULL>	8963	How healthy habits can improve the body well-being and performance of healthcare professionals	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Hospital Israelita Albert Einstein	<NULL>	<NULL>	<NULL>	Healthcare professionals; both sexes; age between 18 and 65 years; active professional link with the institution; day, evening, or night work shift; agreement to participate and provision of written informed consent; clinical ability to participate in a lifestyle change program including nutritional guidance and encouragement of physical activity.	Uncontrolled chronic diseases; clinical or physical conditions that prevent safe participation in a lifestyle change program including nutritional guidance and encouragement of physical activity; use of medications that significantly interfere with body weight or body composition; pregnancy; breastfeeding; concurrent participation in another intervention study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-7fgjdxb	A double-blind randomized clinical evaluation of a bulk-fill resin composite in posterior restorations	Not yet recruiting	Intervention	2026-03-09	<NULL>	<NULL>	8954	Clinical evaluation of a fast and high-power curing bulk-fill resin composite in posterior restorations: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-03	Universidade Estadual de Ponta Grossa	<NULL>	<NULL>	<NULL>	Participants aged 18–70 years; participants clinically healthy; participants presenting at least 20 teeth in occlusion and an acceptable level of oral hygiene; each participant must require at least two Class I or II restorations in vital teeth with cavities of similar horizontal and vertical dimensions; the selected teeth must present functional occlusion with the natural antagonist tooth and proximal contact with adjacent teeth; pulp vitality will be confirmed by means of a thermal test using a cold spray and periapical radiography; a positive response will be considered when it occurs within 10 seconds after stimulus application and is characterized by mild, short-lasting pain, consistent with a vital pulp	Participants that present unsatisfactory oral hygiene characterized by a Simplified Oral Hygiene Index  greater than 3; participants diagnosed with chronic or advanced periodontitis, defined as probing depth greater than 4 mm, presence of bleeding on probing, participants with clinical attachment loss greater than 3 mm in more than four teeth; participants with fixed orthodontic appliances; participants that present significant occlusal wear in more than 10 posterior teeth; participants that require endodontic treatment; participants that presente hypersensitivity to resin-based composite materials or to any other materials used in this study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-9h7h2d5	Use of botulinum toxin to treat Complex Regional Pain Syndrome and its effects on skin nerves	Recruiting	Intervention	2026-03-09	<NULL>	<NULL>	8955	Effect of Incobotulinumtoxin-A in Complex Regional Pain Syndrome: Analysis of Nerve Fiber Density in Skin Biopsies	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Departamento de Medicina Clínica da Universidade Federal do Ceará	<NULL>	<NULL>	<NULL>	Patients diagnosed with complex regional pain syndrome according to the Budapest criteria; age equal to or greater than 18 years; chronic pain refractory to conventional clinical treatment; ability to understand and sign the informed consent form	Pregnancy; active infection at the procedure site; uncorrected coagulopathies; severe psychiatric disorders that impair clinical evaluation; inability to understand the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-9shcypr	Antimicrobian photdynamic therapy applied in necrosis of the jaw bones	Recruitment completed	Intervention	2026-03-09	<NULL>	<NULL>	8956	aPDT applied in osteonecrosis of the jaws	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-15	Fundação Antônio Prudente	<NULL>	<NULL>	<NULL>	any age; male or female; osteoradionecrosis; medication-related osteonecrosis of the jaws; who signed the Informed Consent Form.	patients who did not have the clinical conditions to undergo antimicrobian photodynamic therapy (aPDT); who did not agree with this therapeutic modality; stage 0	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-10w97w8r	Use of laser in the management of muscle pain in patients with temporomandibular dysfunction	Not yet recruiting	Intervention	2026-03-09	<NULL>	<NULL>	8957	TMD and orofacial pain (OP)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Centro de Pesquisas Odontológicas São Leopoldo Mandic	<NULL>	<NULL>	<NULL>	Participants of both sexes; Aged between 18 to 75 years; Participants diagnosed with bilateral Myalgia-type Temporomandibular dysfunction	Participants with symptoms of Anxiety or Depression; participants identified using a screening instrument; participants who have taken any medication to control Temporomandibular dysfunction  in the 3 months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-934r9sr	Brain activity of individuals with Sickle Cell Disease and Chronic Pain undergoing transcranial Direct Current Stimulation	Recruiting	Intervention	2026-03-09	<NULL>	<NULL>	8958	Dynamic brain connectivity of individuals with Sickle Cell Disease and Chronic Pain undergoing Non-invasive Neuromodulation	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-05	Fundação Universidade Federal do ABC	<NULL>	<NULL>	<NULL>	The study will include individuals with sickle cell disease (SCD), both genders, diagnosed by hemoglobin electrophoresis; aged 18 to 60 years; and with chronic primary musculoskeletal pain, diagnosed according to ICD 11 criteria, lasting three months or more. The group of individuals with SCD will consist of 40 individuals. The control group will include healthy individuals (without chronic pain and without SCD), matched by sex and age to the SCD and chronic pain group. The control group will consist of 20 individuals. Individuals with cochlear implants; cardiac pacemakers; or metal implants in the brain/ a history of traumatic brain injury; pregnancy; or a history of seizures or epilepsy will not be included in the study. The use of medications that modify the neuronal activation threshold (e.g., antidepressants, anticonvulsants, and antipsychotics) will be controlled	Individuals who wish to discontinue participation at any time or who experience any complications with the procedures will be excluded from the study. In this case, the data will be processed according to the intention to treat model, with the most recent results being repeated	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:12
RBR-6gzd5dt	Comparison of Acetabular Component positioning between two surgical approaches in total hip arthroplasty	Recruiting	Intervention	2026-03-06	<NULL>	<NULL>	8951	Positioning of the Acetabular Component in Total Hip Arthroplasty performed through the Conventional Posterior Access x Modified Posterior Acces (SPAIRE): prospective randomized comparative study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-05	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients on the primary hip replacement waiting list who have hip osteoarthritis. Patients who are able to read and understand the Informed Consent Form. Age 18 or older. Both sexes	Patients with neurological or orthopedic diseases that alter the gait pattern and may influence functional tests. Need for additional procedures beyond hip prosthesis (shortening osteotomies, need for structured or impacted bone graft, and ankylosed hips or those requiring in situ osteotomy)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-8ngp7d6	Using virtual reality and partial body weight support to improve walking after stroke	Not yet recruiting	Intervention	2026-03-06	<NULL>	<NULL>	8952	Impact of Virtual Reality Combined with Partial Body Weight Support on Gait Rehabilitation after Stroke	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Participants of both sexes; aged between 40 and 75 years; post-stroke in the chronic phase more than 6 months after the event; with hemiparesia; independent walking ability without use of assistive walking devices for at least 10 meters; ability to understand commands; body weight equal to or greater than 30kg	Participants presenting other significant neuromuscular and orthopedic conditions that may interfere with gait or contraindications for virtual reality use such as photosensitive epilepsy or severe cognitive impairment; participants will be excluded who present persistent motion sickness cyber-nausea after the acclimation period or serious adverse events during the session such as severe dizziness or extreme fatigue	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-35mh62v	Effects of an eight-week Adapted Cultivating Emotional Balance Training (ACEBT) on mental health symptoms, brain activity and heart rate variability in university students	Recruitment completed	Intervention	2026-03-06	<NULL>	<NULL>	8953	Effects of an eight-week Adapted Cultivating Emotional Balance Training (ACEBT) on mental health symptoms, brain activity and heart rate variability in university students: a randomized controlled crossover trial assessed with functional magnetic resonance imaging	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-11	Sociedade Beneficente Israelita Brasileira Albert Einstein	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; any gender; be able to participate in all stages of the study	Present contraindication for performing magnetic resonance imaging (according to a standardized questionnaire from the imaging department of this institution); current diagnosis of psychiatric disorder or neurological disease reported by the participant	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-7wzpzfr	How body tissue massage may help women with severe menstrual cramps	Recruiting	Intervention	2026-03-05	<NULL>	<NULL>	8934	Effects of connective tissue manipulation in the treatment of women with primary dysmenorrhea: A clinical trial, double-blinded, placebo-controlled	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-27	Centro de Ciências Biológicas e da Saúde	<NULL>	<NULL>	<NULL>	Nulliparous women; aged 18 to 35 years; regular menstrual cycle; menstruated in the last 30 days; complaints of menstrual cramps; abdominal or pelvic pain before or during menstruation with intensity ≥ 4 on the Numeric Pain Rating Scale; pain onset 6 to 12 months after menarche	History of recent menstrual pain (&lt;1 year); pregnant or suspected pregnancy; body mass index (BMI) above 32; use of any intrauterine device; history or diagnosis of secondary dysmenorrhea; use of oral contraceptives or antidepressants; suspected pregnancy during the study; confirmed pregnancy during the study; suspected or diagnosed secondary dysmenorrhea during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-37fzkwz	Probiotic supplementation improves gastrointestinal and psychological symptoms in stressed university students	Data analysis completed	Intervention	2026-03-05	<NULL>	<NULL>	8943	Intestinal modulation and its effects on gastrointestinal symptoms, the neuroendocrine system, and metabolic parameters in university students	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-10	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Undergraduate student ; self-reported stress; presence of gastrointestinal symptoms.	Current treatment for gastrointestinal symptoms (medications or probiotic supplements) or for anxiety/depression (antidepressants, anxiolytics, or antibiotics) within the past three months; any physical limitation or disability.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-6czzb2f	Effect of Weight training combined with Laser blanket therapy on Physical Performance and overall Well-being in elderly women	Recruiting	Intervention	2026-03-05	<NULL>	<NULL>	8944	Effect of Strength training combined with Low-intensity Laser therapy on Functional Capacity, Quality of Life, and Physical Fitness in elderly women	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-02	Universidade Católica De Brasília	<NULL>	<NULL>	<NULL>	Thirty women aged 60 or older who have been sedentary for at least three months will be selected	Women who participate in less than 80 percent of the training sessions will be excluded, resulting in the loss of the sample; Participation in another strength training program; Use of hormone replacement therapy; Inability to understand instructions due to uncontrolled hypertension, including non-adherence to treatment, undertreatment, inadequate medication, unavailability of medication in the primary health care network, quantity and number of daily doses inconsistent with prescribed medication, resistance to treatment, and presence of comorbidities; Reports of chest pain, dizziness, or malaise; Osteomyoarticular problems or any other pre-existing condition that prevents participation in the physical exercise program; Inability to understand instructions due to cognitive problems	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-4xqk4hv	Ozonized Sunflower Oil in Treating Tooth Sensitivity After Deep Cleaning: Randomized Clinical Study	Terminated	Intervention	2026-03-05	<NULL>	<NULL>	8945	Ozonized Sunflower Oil in the management of Dentin Hypersensitivity after Basic Periodontal Treatment: randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Estadual do Oeste do Paraná	<NULL>	<NULL>	<NULL>	Patients without systemic conditions or smoking habits, presenting periodontal pockets between 4 and 5 mm and sensitivity to evaporative stimuli, will be included; participants must not present gingival recession greater than 2 mm; must not have used dentin hypersensitivity control methods in the past 6 months; and must not use antibiotics during treatment; sensitivity measured on the Visual Analogue Scale (VAS) must be greater than 4 cm	Teeth with recent restorations; patients under chronic use of analgesics or psychotropic drugs; those wearing orthodontic appliances; or those who have undergone recent desensitizing treatment will be excluded; pregnant or breastfeeding women; as well as patients with occlusal dysfunctions, active carious lesions, or parafunctional habits, will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-49rgf8h	Women, Immunology, Nutrition and Exercise (WINE project)	Not yet recruiting	Observational	2026-03-05	<NULL>	<NULL>	8946	Women, Immunology, Nutrition and Exercise (WINE project): An approach to female physiology focusing on sex hormone receptors and monocyte morphofunctionality according to reproductive phases	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Estadual Paulista Julio de Mesquita Filho	<NULL>	<NULL>	<NULL>	Healthy women; Regular menstrual cycle for women in the reproductive phase; Non-users of hormonal contraceptive methods; Non-dependent on hormone replacement	When these inclusion criteria are not met, volunteers will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-32m7jn9	Development of Virtual Environment for Learning about Syphilis in Primary Care: Teaching Tool with Health Science Student	Data analysis completed	Intervention	2026-03-05	<NULL>	<NULL>	8947	Construction and validation of a Clinical Simulation scenario for teaching syphilis management in Primary Health Care: a teaching tool for undergraduate health students	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Potiguar	<NULL>	<NULL>	<NULL>	To be a regularly enrolled nursing student between the 5th and 7th semester; have at least 75% attendance in the course	Absence from any stage of the intervention or from the application of the instruments; being a scholarship holder or a collaborator of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-83y3x8b	Cycles Associated with Executive Functions (CAFE): proposal for a speech therapy model for children with speech sound exchange problems	Terminated	Intervention	2026-03-05	<NULL>	<NULL>	8948	Phonological Disorder: application of therapy models	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-25	Universidade Federal de Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Children aged between six and eight; both sexes; diagnosed with Phonological Disorder - PD with medium-moderate or moderate-severe degrees of severity; that did not present expressive phonetic changes or did not present phonetic distortions in non-acquired phonemes; and who had not undergone (or were undergoing) speech therapy	Children whose guardians did not sign the Informed Consent Form (TCLE) or requested exclusion from the research; who did not agree to the Assent Form (TA) and who did not present a diagnosis of Phonological Disorder - PD or who presented a Phonological Disorder with a medium or severe degree of severity; with hearing loss; with evident neurological changes, with impairment of intellectual abilities; with expressive phonetic changes or that presented phonetic distortions in non-acquired phonemes; unable to understand speech and/or with expressive language changes in linguistic domains (in addition to phonology)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-1088cyz6	Effect of a Mindful Eating program in patients with Fatty Liver	Recruiting	Intervention	2026-03-05	<NULL>	<NULL>	8949	Effect of a Mindful Eating program in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-30	Faculdade de Medicina da Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Patients diagnosed with Metabolic Dysfunction-Associated Steatotic Liver Disease - MASLD by imaging method or liver biopsy; age between 18 and 65 years; agreement to participate in the study and signing of the Informed Consent Form; both sexes	Age over 65 years of both sexes; illiterate individuals; diagnosis of decompensated liver cirrhosis or Child-Pugh B or C; patients with liver cancer; individuals who do not have digital skills; individuals who have practiced mindfulness, meditation or yoga in the last 6 months (with regular practice of at least 3 times a week); individuals who are in an acute phase of depression and/or have a high score on the Depression Anxiety Stress Scale - 21 items (DASS-21); individuals diagnosed with schizophrenia and at suicide risk; pregnant women; individuals with untreated hypothyroidism and/or hyperthyroidism, Cushing&apos;s syndrome and individuals who have undergone bariatric surgery (less than 5 years ago); patients who have not participated in the leveling session to start the groups; patients who have been using orlistat, bupropion hydrochloride and Glucagon-Like Peptide - 1 (GLP-1) analogues for less than 6 months or whose dose has been modified in the last 6 months; patients using tamoxifen, methotrexate, corticosteroids, amiodarone and sodium valproate; women with alcohol consumption greater than 20g/day (140g/week) and men with consumption greater than 30g/day (210g/week); patients who have obtained a score below stage 3 (preparation) in the readiness for change questionnaire; patients who have had weight loss greater than 5% in the last 6 months; individuals who have undergone cancer treatment less than 5 years ago, except for basal cell and squamous cell skin cancer	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-2th4cc3	The impact of audiovisual stimulation with brain frequencies on the health of adults with mild cognitive impairment	Not yet recruiting	Intervention	2026-03-05	<NULL>	<NULL>	8950	The impact of audiovisual stimulation with gamma and theta frequencies on cognitive, mental, and physical health and blood BDNF concentrations in adults with mild cognitive impairment: a randomized multicenter clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-15	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 50 and 69 years; diagnosed with mild cognitive impairment (MCI); possessing a score higher than 12, without a diagnosis of dementia, and lower than 26 points on the MoCA test.	Individuals with epilepsy; immunocompromised individuals; those with oncological and infectious diseases; those diagnosed with bipolar disorder; those with pacemakers; and participants with hypersensitivity to light.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-9pgwwx4	Exercises to facilitate labor	Suspended	Intervention	2026-03-04	<NULL>	<NULL>	8937	Effectiveness of pelvic mobility exercises in labor: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-08	Faculdade de Enfermagem da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	The mother must be over 14 years old and in the active phase of labor; with cervical dilation between 4 and 7 centimeters; two or more reported painful contractions within 10 minutes; a live fetus in cephalic vertex presentation; and in good condition; as assessed by cardiotocography or ultrasound	A woman in labor with a history of previous cesarean section or any prior indication for this surgical procedure; a woman in labor who refuses to remain in the positions proposed in the forward-leaning version exercises; rebozo and side-lying release; a woman in labor diagnosed with chronic or gestational hypertension; glaucoma; injury to the head; shoulder; or spine for at least one year; a woman in labor who has used analgesic medication less than 6 hours prior to admission to the study; if for any reason there are interventions by an external team in the care of the woman in labor that interfere with the management of labor; she will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-6ybhq2y	Hormone therapy and healing of dental implants in transgender individuals	Not yet recruiting	Observational	2026-03-04	<NULL>	<NULL>	8938	Evaluation of osseointegration and healing of dental implants with prosthetic loading in transgender individuals with and without hormone therapy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-25	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Individuals aged between 18 and 60 years; transgender individuals classified according to gender identity as trans men or trans women; using or not using gender-affirming hormone therapy (gaht); with clinical indication for oral rehabilitation through dental implants; presenting good general systemic health	Refusal to sign the informed consent form (icf); uncontrolled diabetes mellitus; active chronic or aggressive periodontal disease; continuous use of medications that interfere with bone metabolism such as corticosteroids or bisphosphonates; chronic infections of any nature; prolonged use of anti-inflammatory drugs or antibiotics; severe bruxism; current pregnancy or planning pregnancy within the next year; previous radiotherapy in the head and neck region; metabolic or systemic diseases affecting bone metabolism	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-6nffmc2	Use of virtual reality, therapeutic play, and music for pain relief during vaccination in children aged 4 to 6 years	Not yet recruiting	Intervention	2026-03-04	<NULL>	<NULL>	8939	Effect of virtual reality, instructional therapeutic play, and music therapy versus usual care on pain during vaccination in children aged 4 to 6 years: a pilot randomized clinical trial protocol	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-07-01	Universidade Estadual de Feira de Santana	<NULL>	<NULL>	<NULL>	Age 4 to 6 years 11 months and 29 days. Both sexes. Child awake. Child accompanied by parents or legal guardian over 18 years of age capable of consenting and native Portuguese speaker. No analgesics or sedatives received in the 12 hours prior to enrollment. Indication for varicella vaccine	Fever ≥ 37.5°C on the day. Undergone needle interventions on the same day. Diagnosed with cognitive deficit or any psychiatric condition such as autism depression or anxiety. Severe neurological conditions that alter behavioral assessment such as epilepsy cerebral palsy or seizures. Withdrawal by the guardian. Visual or hearing impairment. Oculomotor and convergence disorders such as strabismus or nystagmus. History of migraine or labyrinthitis. Head injuries preventing painless placement of VR glasses	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-799zh2r	Memory performance after intervention with cognitive tasks in young tennis players	Recruitment completed	Intervention	2026-03-04	<NULL>	<NULL>	8940	Working memory performance after intervention with cognitively enriched tasks in young tennis players: design of a crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-02	Faculdade De Educação Física - FEF/UnB	<NULL>	<NULL>	<NULL>	Young tennis athletes of both sexes; aged between 9 and 11 years; stage 1 green of the Play and Stay method; typical development; participation in weekly structured tennis training sessions of at least 60 minutes in the three months prior to the start of the research	Completion of stage 2 (orange) of the Play and Stay method; neurodivergent individuals; use of psychotropic medications; less than 60 minutes of structured tennis training per week; consuming food and/or beverages containing caffeine two hours before the session	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-95ptyjx	Music Therapy for impulsivity in Parkinson’s Disease: a clinical trial	Not yet recruiting	Intervention	2026-03-04	<NULL>	<NULL>	8941	Effect of Music Therapy on Inhibitory Control in Parkinson&apos;s Disease: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal do Paraná - Ciências Humanas e Sociais	<NULL>	<NULL>	<NULL>	Participants with an established diagnosis of idiopathic Parkinson’s disease; at stages one to three on the Hoehn and Yahr scale; with a score equal to or greater than 24 on the Montreal Cognitive Assessment (MoCA); of both sexes	Participants diagnosed with other neurological disorders; visual and/or auditory deficits that compromise the understanding and performance of the activities; and participants who are currently receiving therapeutic treatment for cognitive disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-8k2tq29	Differences between dentures made the traditional way and those made with 3D printing	Not yet recruiting	Intervention	2026-03-04	<NULL>	<NULL>	8942	Conventional complete dentures vs. 3D-printed complete dentures	<NULL>	n/a, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Participants who have been completely edentulous for at least 1 year; individuals seeking oral rehabilitation at the complete denture service at the Faculty of Dentistry of Pernambuco (FOP/UPE); participants who agree to participate in this research by signing the Informed Consent Form; participants over 18 years of age; both sexes; participants classified as class 1 or class 2 in the Dental Prosthesis Diagnostic Index for complete edentulism; participants with sufficient systemic health to attend clinical appointments and the discernment to answer the questionnaires	Individuals with retentive ridges (indication for surgery); individuals with neoplastic and non-neoplastic proliferative processes in the oral mucosa; individuals with alterations in the oral mucosa resulting from microbial infections; individuals with neuromuscular disorders.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-6rfsd5k	Evaluation of activity capacity in patients who recovered from COVID-19 before hospital discharge	Recruitment completed	Observational	2026-03-03	<NULL>	<NULL>	8928	Functional Assessment in Hospitalized Patients with Infectious Diseases	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Instituto Nacional de Infectologia Evandro Chagas - INI/Fiocruz	<NULL>	<NULL>	<NULL>	Participants of both sexes; aged between 18 and 79 years, who met hospital discharge criteria were included in the study and were subsequently divided into two groups.The first group (G1) consisted of patients considered fit to perform physical tests for functional assessment and who did not present the following conditions: (1) abdominal aortic aneurysm; (2) functional class IV dyspnea according to the New York Heart Association classification; (3) presence of drains; (4) continuous intravenous infusion; (5) pain scored as 8 on the visual analog scale; (6) osteomuscular disease preventing assessment; (7) nothing by mouth (NPO) status; and (8) deep vein thrombosis.The second group (G2) consisted of patients not fit to perform physical tests for functional assessment due to presenting one or more of the conditions described above, and their functional status was evaluated only using the Barthel Index.	The following were considered exclusion criteria: hemodynamic instability; delirium; cognitive impairment preventing understanding of the tests; refusal to participate in the study; and inability to communicate verbally.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-102symy9	Use of Photobiomodulation Therapy at acupuncture points associated with Physical exercise in the treatment of knee osteoarthritis	Recruiting	Intervention	2026-03-03	<NULL>	<NULL>	8929	Photobiomodulation Therapy at acupuncture points associated with Physical exercise in the treatment of Knee Osteoarthritis: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-26	Universidade Brasil	<NULL>	<NULL>	<NULL>	Diagnosis of KOA grades II and III proven by radiological examination according to the American College of Rheumatology - Kellgren-Lawrence criteria (Link et al., 2013); female; age between 50 and 70 years; body mass index (BMI) between 22 and 30 kg/m²; classified as little active and irregularly active according to criteria established by the International Physical Activity Questionnaire – short version (IPAQ);  availability to participate in the treatment plan; clinical signs such as pain and joint stiffness in at least one of the compartments of the knee joint (medial or lateral tibiofemoral and patellofemoral joint)	Medical restrictions that make it impossible to participate in the study evaluations (cardio-respiratory, rheumatic, neurological and vestibular changes); systemic arthritis; body mass index greater than 30 kg/m2; symptomatic hip OA; use of conventional, unconventional or alternative treatments (acupuncture, physiotherapy and/or intra-articular corticosteroid or hyaluronic acid injections during the last 3 months) that could potentially have effects on the study results and absolute contraindication for the application of irradiation ( neoplasms or photosensitivity)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-9pxcvdr	The impact of Mindfulness on controlling Awake Bruxism: a clinical study with comparative groups	Recruiting	Intervention	2026-03-03	<NULL>	<NULL>	8930	Effectiveness of Mindfulness-based intervention in controlling Awake Bruxism: a randomized controlled clinical trial	<NULL>	1, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-15	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Participants must present good general health; own an iOS device with WhatsApp; have cognitive ability to respond to ecological momentary assessment and questionnaires; present a diagnosis of probable awake bruxism based on self-report and clinical signs; be between 18 and 45 years of age; and may be of either sex	Exclusion criteria include the use of psychotropic medications such as anxiolytics antidepressants or muscle relaxants or the use of stimulant substances; uncontrolled psychological or psychiatric conditions such as severe depression anxiety or schizophrenia; neurological disorders such as dystonia or Parkinson disease; severe orofacial pathologies or decompensated systemic conditions; absence of electronic devices compatible with the recording of awake bruxism episodes; and history of treatment for awake bruxism within the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-8qf7srs	Oral use of Oats in humans	Data analysis completed	Intervention	2026-03-03	<NULL>	<NULL>	8931	The use of oat Beta-Glucan as a bioactive agent in the treatment of Dyslipidemias	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Collaborating individuals from the Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ); who are between 18 and 50 years old; both sexes; those with dyslipidemia	Pregnant women; use cholesterol medications; who do not accept to participate in the research; who do not sign the Free and Informed Consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-59xgczn	Effects of a home-based exercise preparation program on the physical and emotional health of people with Obesity waiting for stomach reduction surgery	Not yet recruiting	Intervention	2026-03-03	<NULL>	<NULL>	8932	Effects of a home-based prehabilitation program on the physical and psychological aspects of individuals with Obesity waiting for metabolic and bariatric surgery	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-20	Universidade do Estado de Santa Catarina - UDESC	<NULL>	<NULL>	<NULL>	People of both sexes; 18 years of age or older; with grade III (severe) obesity; body mass index (BMI) &gt; 40 kg/m2; indication for bariatric surgery; formal indication for preoperative physiotherapy; absence of comorbidities that compromise the safety or ability to perform physical and functional tests applied in the study (e.g., six-minute walk test, 5-repetition chair stand-up test)	History of previous bariatric surgery; previous clinical diagnosis of acute or chronic respiratory diseases that may compromise the safety of physical tests (e.g., COPD, asthma with remodeling); abdominal or thoracic surgeries performed in the last year; pacemaker use; history of myocardial infarction in the last three months or unstable angina pectoris; sustained or episodic cardiac arrhythmias that may be aggravated by physical activity; symptomatic peripheral vascular disease; any other clinical condition that, at the discretion of the responsible investigator, represents a risk or impossibility of participation in the study; abuse of or chemical dependence on psychoactive substances (including alcohol and illicit drugs), according to clinical criteria and/or previous diagnosis; cognitive and physical alterations that prevent the performance of the tests	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-368y8pw	Cross-sectional study of non-classical B cell signatures in Brazilian patients with Crohn’s Disease	Recruiting	Observational	2026-03-03	<NULL>	<NULL>	8933	Analysis of intestinal mucosa and fat nearby the intestine in patients with Crohn&apos;s disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-10-25	Hospital de Clínicas - Universidade Estadual de Campinas (UNICAMP)	<NULL>	<NULL>	<NULL>	Patients with endoscopic and histological diagnosis of ileocecal Crohn&apos;s disease undergoing surgical procedure, both genders. For the control group of distal ileum, patients who underwent colonoscopy for other reasons, whose examination comes without endoscopic changes. For the control group of mesenteric adipose tissue (intestinal fat), patients with non-inflammatory diseases of the left colon undergoing surgery, with normal terminal ileum. All survey participants are over 18 years of age	The patients participating in the control groups without the use of medication. And Crohn&apos;s patients with disease locations other than the small intestine	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-5svckjw	Evaluation of the effects of Essential Oils on the reduction of Stress, Anxiety, and Insomnia and on Smoking Reduction among healthcare professionals	Data analysis completed	Intervention	2026-03-03	<NULL>	<NULL>	8935	Evaluation of the effectiveness of Aromatherapy in reducing levels of Stress, Anxiety, and Tobacco Use and in improving Sleep Quality among healthcare workers	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-15	Escola de Enfermagem da Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Workers aged 18 years or older; of both sexes and different genders; who reported daily tobacco consumption for at least one year and who voluntarily agreed to participate in the study by providing written informed consent	Exclusion criteria comprised concurrent participation in another smoking cessation treatment; pregnancy; participants who entered medical leave or vacation during the study period and individuals with a diagnosis of asthma or severe allergic rhinitis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-8nb3nmh	Immediate effects of a single Yoga session on neurological, physiological, and psychological parameters in caregivers of patients with dementia: a randomized controlled crossover study	Recruiting	Intervention	2026-03-03	<NULL>	<NULL>	8936	Acute effects of a single Yoga session on neurophysiological and psychological parameters in caregivers of patients with dementia: a randomized controlled crossover study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-07	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Primary caregivers of people with some type of dementia; non-professional; of both sexes; aged between 40 and 75 years; with medical clearance to perform physical exercise.	Illiterate individuals and/or people with cognitive impairment to understand the research procedures; those with psychiatric comorbidities (except for depression and anxiety disorders); history of cerebrovascular infarction, functional classes III and IV according to the New York Heart Association criteria; uncontrolled hypertension and diabetes mellitus; uncontrolled physical morbidities and inability to lie down and get up from the floor without assistance.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-65ynybq	Effectiveness of a Behavioral Approach to Physical Activity in Adults	Not yet recruiting	Intervention	2026-03-02	<NULL>	<NULL>	8925	Effectiveness of a Behavioral Intervention in Physical Activity Practice Among Adults	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Escola de Educação Física e Esporte da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Aged between 40 and 70 years. Active staff member of the University of São Paulo with a weekly workload greater than 30 hours. Reporting less than 150 minutes per week of moderate intensity physical activity. Availability to participate in all stages of the 16 week protocol	Medical contraindications to moderate intensity physical activity identified during initial screening using the Physical Activity Readiness Questionnaire and health history assessment. Pregnancy or planned extended leave from work during the study period. Participation in another formal physical activity program involving more than 150 minutes per week of moderate intensity physical activity. Refusal to use monitoring devices including triaxial accelerometer and smartband	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-10dt7q8m	Innovative treatment for chronic pain relief	Not yet recruiting	Intervention	2026-03-02	<NULL>	<NULL>	8926	Scrambler therapy in the management of chronic pain	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-26	Centro Universitário das Faculdades Associadas de Ensino - FAE/UNIFAE	<NULL>	<NULL>	<NULL>	Adults between 18 and 65 years of age of both sexes with a clinical diagnosis of chronic low back pain for at least 3 months will be included	Individuals with previous lumbar surgeries; pacemaker use; pregnant women; individuals with severe neurological diseases; presence of systemic inflammatory processes; cancer diagnosis; those involved in labor litigation related to low back pain will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-2xvc6gr	Photobiomodulation in the treatment of symptoms caused by chemotherapy in the upper limbs	Recruiting	Intervention	2026-03-02	<NULL>	<NULL>	8927	Photobiomodulation in the prevention of chemotherapy-induced peripheral neuropathy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-03	Centro Universitário das Faculdades Associadas de Ensino - FAE	<NULL>	<NULL>	<NULL>	Those who have previously used vitamin B; analgesics such as paracetamol or NSAIDs (non-steroidal antiinflammatory drugs); and nonpharmacological approaches such as conventional physiotherapy; massages or unsupervised home exercises will be included	Patients with a history of peripheral neurological disease prior to chemotherapy; decompensated diabetes mellitus (blood glucose180 mgdL (milligrams per deciliter)); chronic alcoholism or current use of specific pharmacological agents for the treatment of CIPN (chemotherapy induced peripheral neuropathy) will be excluded; Patients who begin any type of structured physical intervention during the study will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-85wj6tj	Effect of supplementation with fruit-based carbohydrate gel on physical performance and gastrointestinal discomfort in healthy high-performance athletes	Recruiting	Intervention	2026-02-27	<NULL>	<NULL>	8922	Effect of supplementation with fruit-based carbohydrate gel on physical performance and gastrointestinal discomfort in healthy high-performance athletes: a non-inferiority, crossover, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-17	Centro Universitário São Camilo	<NULL>	<NULL>	<NULL>	Adult men and women; aged between 18 and 59 years; with experience in long-duration exercises (running over 21 km) for at least 1 year	People with limitations in their respiratory or cardiovascular systems; who use ergogenic supplements chronically (e.g., beta-alanine and creatine); who use hormones or medications that modify physical performance; or who have any muscle injury that prevents them from performing the performance test; people with gastrointestinal diseases (e.g., irritable bowel syndrome or short bowel syndrome, Crohn&apos;s disease, among others); people who use prebiotic, probiotic, synbiotic supplements or use medications such as antibiotics, laxatives, antidiarrheals, antiemetics, antacids, or any substances that affect the gastrointestinal tract.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-8f2t7ww	Evaluation of the implementation of a protocol to reduce the amount of blood collected in critically ill patients admitted to the intensive care unit after major surgery or in shock.	Recruitment completed	Intervention	2026-02-27	<NULL>	<NULL>	8923	Feasibility Study of the Implementation of a Reduced-Volume Laboratory Blood Collection Protocol in Critically Ill Patients Undergoing Major Surgery or Shock.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-09	Unimed de Joinville Cooperativa de Trabalho Medico	<NULL>	<NULL>	<NULL>	Age ≥ 18 years; both sexes;  admitted to the intensive care unit for postoperative care following major surgery or for shock requiring vasopressor use; with the presence of a central venous catheter and/or arterial access	Hemodynamic instability refractory to treatment; severe coagulopathy; severe anemia with hemoglobin lower than 7 grams per deciliter; hemoglobin decrease greater than or equal to 3 grams per deciliter within 24 hours	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-5mcym7y	Subcutaneous irrigation with 2% aqueous chlorhexidine vs. 0.9% saline solution in open bariatric surgery: randomized controlled trial.	Data analysis completed	Intervention	2026-02-27	<NULL>	<NULL>	8924	Intraoperative subcutaneous irrigation with 2% aqueous chlorhexidine vs. 0.9% saline solution and surgical wound infection rate in open bariatric bypass surgery: a prospective randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Irmandade da Santa Casa de Misericordia de Curitiba	<NULL>	<NULL>	<NULL>	Paciente who have undergone open bariatric bypass surgery; patients &gt;= 18 years old and &lt;=65 years old; both sexes (female and male)	Patients allergic to chlorhexidine; videolaparoscopic bariatric surgery; sleeve gastrectomy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-9vr6jyf	Effects of an accessible, low-cost, and individualized physical exercise program on the mobility of people with Mucopolysaccharidosis	Data analysis completed	Intervention	2026-02-26	<NULL>	<NULL>	8899	Impact of an accessible, low-cost, and individualized fhysical rehabilitation program on the functional capacity of patients with Mucopolysaccharidosis	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-05	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Individuals with a confirmed diagnosis of Mucopolysaccharidosis (any type) by enzyme assay and/or genotyping; of both sexes; over six years of age; whose guardians signed the informed consent form; under follow-up at the Reference Center for Inborn Errors of Metabolism; and without participation in physical rehabilitation or regular aerobic exercise (greater than 150 minutes/week) in the last six months	Patients unable to walk; with tracheostomies and/or dependent on invasive mechanical ventilation; hospitalized for acute respiratory infection less than 30 days prior to assessment; with severe heart disease; with cognitive impairment, unable to understand verbal instructions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:56
RBR-8jvkfdc	The effect of acute caffeine and capsaicin supplementation on performance and psychophysiological variables	Recruitment completed	Intervention	2026-02-26	<NULL>	<NULL>	8900	Caffeine and capsaicin supplementation during running	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-26	Miércio Soares de Melo	<NULL>	<NULL>	<NULL>	As an inclusion criterion, all runners who do not have joint, muscle, or bone injuries that could interfere with their performance will be accepted into the sample. In addition, they must have been running for 12 consecutive months or more, and have participated in a race with a distance of 10 kilometers or more in the last 12 months.	As an exclusion criterion, all volunteers who present with injuries capable of interfering with their performance during the experiment will be excluded from the sample.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-8f9299p	Study on Manual Therapy for Neck Pan and Balance in Students	Recruitment completed	Intervention	2026-02-26	<NULL>	<NULL>	8901	Effects of Manual Therapy techiniques and Analysis of Postural control and Balance in university students with Nonspecfic Pain a randomided clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-29	Universidade de Brasília - UNB	<NULL>	<NULL>	<NULL>	University students with complaints of neck pain; both genders; aged between 18 and 40 years; not using any controlled medication, except for contraceptives; not undergoing any type of physical therapy or similar treatment	Be pregnant; history of spinal fracture and/or surgery; history of tumor or cancer in the spine, pelvic organs, and/or gastrointestinal tract; skin problems such as mycoses, recent wounds, psoriases, cuts, or dermatitis in general; physical impairments that prevent the performance of the proposed treatments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-10tdtn9r	Study on the use of Bach Flower remedies in the breastfeeding of newborn babies	Recruiting	Intervention	2026-02-26	<NULL>	<NULL>	8919	Nursing mothers under Bach Flower intervention: a controlled, triple-blind, randomized clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-20	Escola Paulista de Enfermagem	<NULL>	<NULL>	<NULL>	Puerperal women over the age of 18 will be included; residents in the city of São Paulo/SP; who have a cell phone to contact, with a single fetus pregnancy; habitual risk, whose children were born alive, with a gestational age equal to or greater than 37 weeks and a newborn weighing equal to and/or greater than 2,500 grams, without complications, with criteria to maintain rooming-in and exclusive breastfeeding after delivery, who present any level of stress, anxiety or symptoms of depression, and who are in the period between 12 and 48 hours after delivery	The exclusion criteria were foreign puerperae; who declared themselves to be illiterate and/or cognitively impaired, regardless of their schooling; unable to read and understand the Informed Consent Form (ICF); with hearing and/or visual impairments; disoriented as to time, space and people; using galactagogues and/or anxiolytics and antidepressants; users of alcohol or illicit drugs; smokers using more than 10 cigarettes/day; with breast malformation or mammoplasty; diagnosed with gestational diabetes, hypothyroidism and/or hyperthyroidism, or any other endocrine disease; body mass index (BMI) equal to or greater than 30kg/m2 in the period prior to pregnancy or up to the first 8 weeks of pregnancy; NB requiring Neonatal Intensive Care Unit support for a period of more than 12 hours; diagnosed with short frenulum; with orofacial alterations	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-6g29z3j	Study comparing different surgical treatments for Labia Minora Hypertrophy	Recruiting	Intervention	2026-02-26	<NULL>	<NULL>	8920	A prospective, randomized, comparative study on the treatment of Labia Minora Hypertrophy using CO2 Laser, Radiofrequency and Cold Scalpel	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women; aged between 18 and 70 years; complaint of labia minora hypertrophy; medical indication for labiaplasty; agreement to participate in the study by signing the Informed Consent Form	Presence of untreated active genitourinary infection; known coagulation disorders; pregnancy or postpartum period; known allergy to the anesthetics used; abnormal genital bleeding; uncontrolled systemic comorbidities that may interfere with wound healing such as decompensated diabetes mellitus, malnutrition or vasculopathies; clinical contraindication for outpatient procedure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-10nhhm4v	Diet and blood Magnesium, Selenium, Folate, Omega-3 and Omega-6 levels in patients with chronic facial pain	Not yet recruiting	Observational	2026-02-26	<NULL>	<NULL>	8921	Food intake and serum levels of Magnesium, Selenium, Folate, Omega-3 and Omega-6 in patients with Chronic Painful Temporomandibular Dysfunction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-05	Departamento de Odontologia Restauradora da Universidade Federal do Ceará Campus Fortaleza	<NULL>	<NULL>	<NULL>	The volunteers will be female; aged between 20 and 45; seeking treatment at the Dentistry course at the Federal University of Ceará; as well as from the general population, recruited through social media and posters; present painful complaints of at least 5, measured on a Numerical Scale ranging from 0 (no pain) to 10 (worst possible), for at least 3 months and with no history of previous treatment for at least three months; the healthy group will consist of women without Temporomandibular Disorders and with no previous history of facial pain complaints	Women with previously diagnosed disabling cognitive, psychological, and neurological disorders;  in addition to a previous diagnosis of chronic kidney disease, liver disease, megaloblastic anemia, or cancer, other chronic painful disorders; abuse of legal drugs and/or alcohol, use of illegal drugs; pregnant and lactating women; volunteers who had lost five or more teeth, poorly fitting dentures, severe periodontal disease, toothache, intraoral or extraoral lesions capable of compromising masticatory function; use of multivitamins or isolated supplements containing magnesium or selenium in the last 30 days; those with systemic conditions likely to cause dietary restrictions, such as lactose intolerance, gluten intolerance, diabetes mellitus, severe irritable bowel syndrome, and inflammatory bowel disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-4f6h6rh	How a Supervised Exercise Program Can Help Women with Obesity Lose Weight and Improve Quality of Life	Recruiting	Intervention	2026-02-25	<NULL>	<NULL>	8902	Effect of Monitored Physical Exercise on Weight Control and Quality of Life in Women with Obesity a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-06	Escola bahiana de medicina e saúde pública - FBDC	<NULL>	<NULL>	<NULL>	Women aged between 40 and 59 years; with a Body Mass Index (BMI) ≥ 30 kg/m²	Use of medications for the treatment of obesity; Medical conditions that prevent the safe performance of physical exercise; Women who are already enrolled in training programs	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-9hdghd3	Esmolol or Remifentanil: a comparison of medications during maxillofacial surgery and patient recovery	Not yet recruiting	Intervention	2026-02-25	<NULL>	<NULL>	8903	Evaluation of intraoperative parameters and quality of postoperative recovery in maxillofacial surgeries with continuous infusion of Esmolol versus Remifentanil: a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-06	Empresa Brasileira De Servicos Hospitalares	<NULL>	<NULL>	<NULL>	Age from 18 years; both genders; American Society of Anesthesiology (ASA) I or II; elective oral and maxillofacial surgery with expected duration between 1h and 3h; signed Free and Informed Consent	Previous diagnosis of atrioventricular block; cardiovascular disease that compromises the use of beta-blockers; diagnosis of asthma or Chronic Obstructive Pulmonary Disease; regular use of opioids; patients with chronic pain	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-6jgjygt	Use of ozone and laser to reduce pain after root canal treatment: a clinical study.	Data analysis completed	Intervention	2026-02-25	<NULL>	<NULL>	8904	Effect of ozone therapy and laser therapy on postoperative discomfort in endodontic treatment: a clinical study.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-10	centro de pesquisa odontologica são leopoldo mandic	<NULL>	<NULL>	<NULL>	Adult participants over 18 years of age, of both sexes and regardless of origin or social class, who attend an endodontic clinic requiring endodontic treatment or retreatment and who have agreed to participate in the research will be included. All participants will sign the informed consent form	Participants will be excluded if they have systemic problems; periodontal problems; are wearing orthodontic appliances; have psychiatric disorders; have serious heart problems; are using topical or systemic; medications and muscle relaxants; anti-inflammatories and,or analgesics; and are pregnant	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-9sgdsm2	Effect of low-power light on perineal injury after vaginal childbirth: a randomized, controlled, blinded clinical trial	Recruiting	Intervention	2026-02-25	<NULL>	<NULL>	8905	Efficacy of photobiomodulation in postpartum vaginal perineal trauma: a randomized, controlled, and blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Faculdade de Ciências da Saúde do Trairí	<NULL>	<NULL>	<NULL>	Age greater than 15 years; pain score greater than or equal to 3 on the Numerical Pain Rating Scale; presence of first degree and or second degree perineal trauma and or vulvar edema; immediate postpartum period up to 12 hours	Presence of vaginal wounds; Signs or examination that proves vaginal infection; Vulvar hematoma; Use of anti inflammatory drugs;Difficulty in understanding that makes it impossible to continue the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-6g5ys67	Effects of consuming orange juice with a high-fat meal on metabolism	Data analysis completed	Intervention	2026-02-25	<NULL>	<NULL>	8906	Effects of orange flavonoid intake associated with a high-fat meal and their impact on advanced glycation end products (AGEs) concentrations	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Age between 18 and 30 years; no diagnosed illnesses; not using any medication; not vegan or vegetarian; and no smoking habits.	Smokers; individuals with chronic non-communicable diseases; obese individuals (BMI greater than or equal to 30 kg/m2); individuals with cardiovascular disease and kidney disease; vegetarians/vegans; and breastfeeding mothers.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-8h8hbtx	Muscle strength and an immediate energy boost with coffee	Data analysis completed	Intervention	2026-02-25	<NULL>	<NULL>	8907	Muscle strength and acute caffeine supplementation	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2015-07-01	Universidade de Brasilia	<NULL>	<NULL>	<NULL>	Young men (18 to 30 years old); At least six months of experience in strength training; Be healthy, especially considering cardiovascular and metabolic aspects; Not have any type of injury or joint, muscle, or bone problem that affects the knee extension exercise; Not report increased sensitivity or allergy to caffeine; Not be using anabolic steroids; Not be using supplements containing caffeine for at least one week; Be familiar with the squat exercise; Not be a smoker	Failure to complete all scheduled sessions; Performing resistance exercises, cyclic exercises, or any other type of exercise for the lower limbs during the experimental period that may affect the participant&apos;s performance during the tests; Using ergogenic substances other than those prescribed during the study period; Consuming additional caffeine not planned during the experimental period that may affect the test results	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-249pj8m	Evaluation of educational activities to support caregivers of older adults with dementia in primary health care units	Not yet recruiting	Intervention	2026-02-25	<NULL>	<NULL>	8908	Evaluation of educational workshops for caregivers of older adults with alzheimer’s disease in primary health care	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-09	Escola Paulista de Enfermagem da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Age 18 years or older; performing caregiving activities for at least three months; not receiving remuneration for providing care	Inability to read; older adult under care not registered with or not followed by a primary health care unit participating in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-5r4s3tp	Effects of Circuit Training on the physical and functional  fitness of elderly people	Recruiting	Intervention	2026-02-24	<NULL>	<NULL>	8909	Effects of the Mixed Circuit at High-Speed and Short Duration on indicators of physical complexity and functionalities in elderly individuals	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-03	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Older adults aged 60 years or older; both sexes; referred by the Open University for Older Adults of the State University of Rio de Janeiro; presenting good clinical health status; ability to perform activities of daily living independently; eligible for participation in physical exercise after pre-exercise screening	Presence of uncontrolled cardiovascular, respiratory, neurological, musculoskeletal, or metabolic diseases that contraindicate physical exercise; musculoskeletal limitations that prevent safe execution of the proposed exercises; use of medications or clinical conditions that pose risk during physical exercise; cognitive impairment that prevents understanding and execution of study procedures; concurrent participation in a structured physical training program	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-449rqqm	Lactational Mastitis associated with the use of Low-Intensity Laser Therapy in women treated at a human milk bank	Not yet recruiting	Intervention	2026-02-24	<NULL>	<NULL>	8910	Clinical trial on the occurrence of mastitis in lactating women attended at a human milk bank	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Centro de Ciências da Saúde da Universidade Estadual de Maringá	<NULL>	<NULL>	<NULL>	Women of any age, if a minor accompanied by a guardian, who have given birth within the Unified Health System (SUS); who are breastfeeding for up to six months; who have a diagnosis of classic mastitis, characterized by the presence of at least three signs or symptoms compatible with the diagnosis; or who are using antibiotics for a maximum of 48 hours	Lactating women with mastitis of other etiologies; cases associated with the presence of a breast abscess or area of ​​fluctuation; clinical situations that contraindicate the use of photobiomodulation (such as neoplasms, use of photosensitive drugs, pregnancy, undiagnosed lesions, tattoos or micropigmentation in the affected area); those who have given birth in private services; those who have been breastfeeding for more than six months and have been using antibiotics for more than 48 hours	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-67y8bvs	Strength exercises with elastic bands for hospitalized patients in serious condition who have muscle weakness	Recruiting	Intervention	2026-02-24	<NULL>	<NULL>	8914	Effects of a resistance training protocol using elastic resistance in critically ill patients with muscle weakness: a randomized, controlled, blinded clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Federal de São Carlos (UFSCar)	<NULL>	<NULL>	<NULL>	Age over 18 years; both sexes; critically ill patients hospitalized in the intensive care unit; prior mobility with an Intensive Care Unit Mobility Score of 10; peripheral muscle weakness defined by handgrip strength values lower than 16 for women and lower than 27 for men; or values below the predicted in the five-repetition sit-to-stand test; acceptance to participate in the study	Patients who require orotracheal intubation during protocol execution; worsening of clinical condition or instability preventing training for more than two days; protocol execution time and actigraph monitoring shorter than four days; death; and withdrawal from participation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-53vqd93	Impacts of Physical Exercise on heart health, sleep, memory, muscle strength and quality of life of people with Hypertension	Recruiting	Intervention	2026-02-24	<NULL>	<NULL>	8918	Effect of Physical Training on cardiovascular outcomes, sleep, cognition, strength, functionality and quality of Life in individuals with Hypertension	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-10	Instituto de Educação Superior da Paraíba - IESP	<NULL>	<NULL>	<NULL>	Volunteers with hypertension; both genders; over 18 years of age; non-smokers; with a body mass index of up to 39.9 kg/m²; no history of ischemic or hemorrhagic stroke; coronary disease; chronic obstructive or restrictive pulmonary disease; peripheral artery disease; not practicing regular physical exercise; be available to undergo the experimental protocol	Volunteers with osteomyoarticular diseases that prevented them from engaging in physical activity; who changed their antihypertensive drug therapy during the intervention; who experienced any complications during the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-3mxk7tc	Dental implants enhance denture stability in diabetic patients: Practical and random study	Not yet recruiting	Intervention	2026-02-23	<NULL>	<NULL>	8911	Retention of lower complete dentures by dental implants in diabetic patients: A randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	The inclusion criteria for this study will be: Patients with type I or type II diabetes; Patients who are completely edentulous in the lower arch; Patients who do not wear prostheses or who have inadequate complete dentures; Patients that was submitted to tooth extractions at least 12 months prior to the rehabilitation procedure (completely edentulous for at least 1 year); Patients between 40 and 70 years old	Patients with the following characteristics will be excluded from this study: Partial of dentate patients; Smokers who smoke more than 10 cigarettes per day; Users of medications that alter bone metabolism; Pregnant or breastfeeding; 6) patients who do not understand the terms of the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-23bfm3z	Effects of High-Intensity Respiratory Training on Blood Pressure and Heart Health in People with Hypertension	Recruiting	Intervention	2026-02-23	<NULL>	<NULL>	8912	Effects of High-Intensity Inspiratory Muscle Training on Blood Pressure and Heart Rate Variability in Hypertensive Patients: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal do Delta do Parnaíba	<NULL>	<NULL>	<NULL>	Residents of the city of Parnaíba, Piauí; both sexes; clinical diagnosis of arterial hypertension; age between 50 and 70 years; signed Informed Consent Form; stable medication treatment for more than 2 months; maintenance of medication stability throughout the study	Poor adherence to the protocol; medication changes during the intervention; withdrawal of consent; pregnant women; breastfeeding women; active smokers; systolic blood pressure below 90 millimeters of mercury or above 160 millimeters of mercury; diastolic blood pressure above 100 millimeters of mercury; current or recent history of deep vein thrombosis; severe dyspnea; diabetes mellitus; neurological impairments; cognitive impairments; other cardiovascular diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-6tkt5xm	Effect of speech therapy treatment before orthognathic surgery to improve the muscles of the lips, tongue and cheeks, breathing, chewing, swallowing and speech	Recruiting	Intervention	2026-02-23	<NULL>	<NULL>	8913	Effectiveness of speech therapy in the preoperative phase of orthognathic surgery	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Centro de Ciencias da Saúde	<NULL>	<NULL>	<NULL>	"Men and women between the ages of 18 and 50 who will undergo maxillary and/or mandibular osteotomy for dentofacial correction; Individuals who do not have skin conditions and/or who can discontinue the use of facial acids and who have not used Roaccutane in the last 6 months;
Individuals who are not currently using facial acid treatments; Individuals without craniofacial anomalies; Without cognitive deficits; Who are not allergic to the elastic bandage material"	Patients undergoing physical therapy during the postoperative period; Patients who experienced surgical complications and required special care; Patients who were unable to participate in all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-874hqcw	Resonant leadership development in nurses: effects on missed nursing care and staff turnover	Not yet recruiting	Intervention	2026-02-23	<NULL>	<NULL>	8915	The effect of an educational intervention based on nurses’ resonant leadership on missed nursing care and staff turnover: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-02	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Nurses who meet the following inclusion criteria will be invited to participate in this study: (1) having an active institutional employment relationship for at least three months, considering this period as the minimum experience required by the institution for professional adaptation and integration into the work routine; (2) working in inpatient units (medical and surgical) or intensive care units; and (3) having proficiency in the Portuguese language, as it will be the language used to conduct the educational intervention. For sample selection, non-probabilistic convenience sampling will be used, with the aim of measuring and comparing the frequency with which resonant leadership is perceived by the participants.	Nurses with less than three months of employment at the institution, those who attend less than 75% of the educational intervention, and/or those who do not complete all stages of the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-6yc38q7	Long-term evaluation of dental implants after vertical bone augmentation using different grafting materials	Recruitment completed	Intervention	2026-02-23	<NULL>	<NULL>	8916	Clinical and radiographic evaluation of implants placed in areas undergoing segmental osteotomy with autogenous bone graft or non-ceramic hydroxyapatite inlay in the posterior mandibular region: a 10-year longitudinal study.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2010-01-01	Universidade de Guarulhos	<NULL>	<NULL>	<NULL>	Adult patients requiring rehabilitation with dental implants in the posterior region of the mandible, presenting with vertical bone deficiency indicated for bone augmentation through sandwich-type segmental osteotomy, who participated in the original study and signed the Informed Consent form.	Patients who participated in the original study but could not be located or did not attend the late reassessment are considered losses to follow-up.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-6tmdrtg	Effectiveness and safety of the Butantan-DV single-dose tetravalent vaccine against Dengue: real-world data after mass vaccination in the municipality of Botucatu	Recruiting	Observational	2026-02-23	<NULL>	<NULL>	8917	Mass vaccination for Dengue control in Botucatu: effectiveness and safety profile evaluation of the single-dose tetravalent vaccine Butantan-DV	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-19	Ministério da Saúde	<NULL>	<NULL>	<NULL>	Botucatu residents (case-control and cohort) or Polo Cuesta residents (cohort study only) aged between 15 and 59 years; Individuals with suspected dengue infection to be investigated at Emergency Rooms or Primary Health Care Units; Performance of RT-PCR for dengue for residents of Botucatu and São Manuel (for cases from other Polo Cuesta municipalities, rapid NS1 antigen testing may also be considered).	Not applicable	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-3f5c5hx	Intraoral fluoride retention after using experimental toothpaste containing titanium tetrafluoride and chitosan	Recruitment completed	Intervention	2026-02-22	<NULL>	<NULL>	8896	Evaluation of intraoral levels of Fluoride in saliva, biofilm and biofilm fluid after using experimental dentifrice containing TiF4 and Chitosan	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Faculdade de Odontologia de Bauru, Universidade de São Paulo	<NULL>	<NULL>	<NULL>	individuals of both sexes aged greater than or equal to eighteen years; residents of the city of Bauru state of São Paulo Brazil with fluoride concentration in the public water supply ranging from zero point seventy seven to zero point eighty seven milligrams of fluoride per liter; presenting good general and oral health characterized by the absence of active or cavitated dental caries and absence of significant gingivitis or periodontitis; presenting stimulated salivary flow greater than or equal to one milliliter per minute; presenting unstimulated salivary flow greater than or equal to zero point twenty five milliliters per minute	presence of systemic disease; pregnancy or breastfeeding; use of orthodontic appliances; professional fluoride application within two months prior to the beginning of the study; smoking; use of medications that may interfere with salivary flow or dental biofilm formation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-8rhdjw4	Physiotherapy exercises to improve muscle strength and breathing in people with chronic kidney disease before dialysis: clinical study	Not yet recruiting	Intervention	2026-02-22	<NULL>	<NULL>	8897	Integration of multidimensional physiotherapeutic strategies in the treatment of respiratory and uremic sarcopenia in patients with Chronic Kidney Disease in the pre-dialysis stage: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-15	Departamento de Fisioterapia	<NULL>	<NULL>	<NULL>	Patients with pre-dialysis stage chronic kidney disease, confirmed by clinical or laboratory criteria as prescribed by the National Kidney Foundation, will be included; of both sexes; aged between 30 and 70 years; clinically stable and without recent exacerbations; with the ability to understand and participate in the proposed assessment and exercise program	Patients undergoing renal replacement therapy such as hemodialysis, peritoneal dialysis, or kidney transplantation; those with acute or chronic respiratory diseases; those with neurological and/or musculoskeletal conditions that interfere with performing respiratory exercises; those with cognitive or behavioral impairments that prevent participation in the study or compliance with protocol instructions; and those with any other medical condition that makes them ineligible to participate in the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-4xd6cxm	Use of Personalized Tourniquet Pressure in Knee Arthroscopy.	Recruitment completed	Intervention	2026-02-22	<NULL>	<NULL>	8898	Evaluation of Knee Arthroscopy under  Arterial Occlusion Tourniquet Pressure	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-07	Universidade Federal de Juiz de Fora	<NULL>	<NULL>	<NULL>	Female and male patients, aged between eighteen and forty-five years; with Indication for elective arthroscopic knee procedures (meniscal repair, partial meniscectomy, anterior or posterior cruciate ligament reconstruction); absence of cardiovascular, metabolic, or neurological diseases; clinical eligibility for spinal anesthesia; and ability to provide written informed consent.	Peripheral vascular disease or uncontrolled hypertension; diabetes mellitus, coagulopathies, or autoimmune disorders; previous surgery on the same limb within 12 months; active infection or dermatologic lesion at the cuff site; chronic analgesic or vasoactive medication use; pregnancy; or known neuropathy or intolerance to tourniquet use.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-9sdpc2t	Predictability of Dental Implants in Grafted Bone: Findings from a Clinical Study	Recruiting	Intervention	2026-02-20	<NULL>	<NULL>	8893	Predictability of Implant-Supported Rehabilitations in Grafted Areas: A Randomized Controlled Clinical Trial	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-15	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Be between 18 and 60 years old; have the need for bilateral maxillary sinus floor elevation for subsequent installation of osseointegrated implants; present bone availability associated with the alveolar ridge adjacent to the maxillary sinus of less than or equal to 3mm; be in good systemic health; have at least 4 months of healing in the socket after tooth extraction	Smokers; uncontrolled diabetics; individuals with chronic or aggressive periodontitis; patients using medications that alter bone metabolism; patients with chronic upper respiratory tract infections; patients who chronically use anti-inflammatory drugs and antibiotics; individuals with bruxism; alcoholics; drug addicts; pregnant women or those who wish to become pregnant in the next year; history of radiotherapy treatment in the head and neck region; individuals with pathologies that affect bone metabolism; patients who had a major membrane rupture during the trans-surgical procedure.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-10qp94n8	Expanding PrEP (pre-exposure prophylaxis) options for young gay, trans and non-binary people in Brazil with twice-yearly injections to prevent HIV	Recruiting	Intervention	2026-02-20	<NULL>	<NULL>	8894	Expanding PrEP options among young MSM, transgender and non-binary persons in Brazil: incorporating twice-yearly Lenacapavir for HIV prevention - The ImPrEP LEN Brasil Study	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Insituto Nacional de Infectologia Evandro Chagas/Instituto de Pesquisa Clinica Evandro Chagas	<NULL>	<NULL>	<NULL>	Ability to understand and sign the Informed Consent Form, which must be obtained before the initiation of any study procedures, and agree to comply with the protocol requirements; be a cisgender man, a non binary person designated male at birth, or a transgender woman or transgender man; report having engaged in anal sex with a person designated male at birth within the last six months; be between 16 and 30 years of age; have a body weight equal to or greater than 35 kilograms; seek care at a participating study clinic for human immunodeficiency virus testing or initiation of human immunodeficiency virus pre exposure prophylaxis, either spontaneously or through peer invitation; have a non reactive result on a rapid test for human immunodeficiency virus; be an individual without prior use of human immunodeficiency virus pre exposure prophylaxis or be an individual with prior use of human immunodeficiency virus pre exposure prophylaxis and remain in a situation of vulnerability, characterized by a history of oral human immunodeficiency virus pre exposure prophylaxis with at least two prior dispensations without return for a new pickup in the six months preceding the enrollment visit or a history of long acting cabotegravir use with a delay of at least one scheduled reload dose	Known hypersensitivity to the study medication, its metabolites, or formulation excipients; severe hepatic impairment or a history or current clinical condition of decompensated liver cirrhosis, such as ascites, encephalopathy, or variceal bleeding; known or suspected severe active infection, such as active tuberculosis; need for continuous use of contraindicated concomitant medications; any other clinical or psychosocial condition, or prior treatment, that in the opinion of the investigator makes the participant unsuitable for the study or unable to comply with dosing requirements; confirmed or suspected infection with the human immunodeficiency virus; plans to move outside the study area during the follow up period; prior participation in a clinical study using Lenacapavir in the Purpose study; prior participation in a human immunodeficiency virus vaccine study, except in cases where the participant provides documentation demonstrating receipt of placebo and not the active product; current participation in another interventional human immunodeficiency virus prevention study that, in the opinion of the investigator, may interfere with the conduct of this study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-105h2gww	Effects of the use of virtual reality combined with a circuit-based coordinative approach on the development of children and adolescents with autism	Recruitment completed	Intervention	2026-02-20	<NULL>	<NULL>	8895	Effects of a 24-week intervention using virtual reality combined with a coordinative circuit approach on motor, cognitive, behavioral, and socioemotional performance in children and adolescents with level I autism spectrum disorder: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-15	Universidade Federal do Vale do São Francisco	<NULL>	<NULL>	<NULL>	Children and adolescents of both sexes aged between ten and sixteen years who were literate; children with a confirmed diagnosis of autism spectrum disorder level one based on medical report or specialized assessment; availability to participate in all stages of the study including interventions and assessments; formal consent provided by parents or legal guardians through signing the informed consent form and assent form signed by the participants as well as authorization for the use of images signed by the legal guardian	Presence of severe or progressive neurological comorbidities such as uncontrolled epilepsy severe cerebral palsy or muscular dystrophies; medical contraindications to physical activity or exposure to virtual reality such as severe vestibular disorders; children with severe cognitive impairments that prevented understanding or execution of the proposed tasks; history of intolerance or severe discomfort related to the use of virtual reality headsets; absence from more than three consecutive sessions or total attendance lower than seventy percent of the proposed activities; occurrence of medical conditions or adverse health events during the study that prevented continuation of participation; persistent difficulty in understanding or performing the experimental procedures; identification of any previously unreported condition that contraindicated participation in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-10k7tx4w	Brain Stimulation in Parkinson&apos;s Disease: new findings on Brain, Vision, and Blood Markers	Recruitment completed	Intervention	2026-02-19	<NULL>	<NULL>	8884	Neuromodulation in Parkinson&apos;s Disease: effects on Cortical Activity, Eye Tracking, and Pro-Inflammatory Biomarkers	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-10	Centro de Ciências Humanas, Letras e Artes da Universidade Federal da Paraíba	<NULL>	<NULL>	<NULL>	"The study included people diagnosed with Parkinson disease of both sexes aged up to 60 years (Bagattini et al., 2023). They have a disease staging score between 1.0 and 2.5, which is considered compatible with the development of responses during application of the neurocognitive test battery (Hoehn &amp; Yahr, 1968). They have not been diagnosed with dementia. They have normal or corrected visual acuity, as measured using Rasquin E optotypes
No diagnosis of dementia.
Normal or corrected visual acuity 20/20 measured using Rasquin “E” optotypes."	The presence of metal implants and/or pacemakers. History of seizures. Participants with comorbidities such as diabetes mellitus, high blood pressure, schizophrenia and bipolar disorder. Use of illicit psychoactive substances and/or benzodiazepines within one week of the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-4d6mpkz	Impact of Heart Health Images on Eating and Exercise Habits of University Staff	Not yet recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8885	Effect of Pictorial Cardiovascular Health Communication on dietary and physical activity behaviors among workers of a public university	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Active workers who were part of the previous matrix study; aged between 20 and 59 years; from the teaching, research, or administrative staff careers at a public university	Workers on sick leave; maternity leave	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-3wg7d8x	Effect of Kinesio Taping on edema, pain, and trismus in the postoperative period of Orthognathic Surgery: a randomized controlled clinical trial	Recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8886	Effect of Kinesio Taping on clinical parameters in the postoperative period of Orthognathic Surgery: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-08	Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Participants aged 18 years or older; of both sexes; with Class III dentofacial deformity; undergoing orthognathic surgery.	Presence of comorbidities or chronic use of medications with potential influence on postoperative edema; hypersensitivity to elastic therapeutic taping; failure to attend postoperative follow-up visits or withdrawal from the study; occurrence of postoperative infection, surgical wound dehiscence, or undesirable fractures during the intraoperative period.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-5h3nr7m	Training with bands that restrict blood flow for people with Pulmonary emphysema: a randomized feasibility clinical study	Recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8887	Blood flow restriction training in COPD: a randomized controlled feasibility study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-20	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	<NULL>	<NULL>	<NULL>	Chronic obstructive pulmonary disease with moderate to severe airflow obstruction; minimum age of 40 years; of both sexes; on optimized pulmonary medication; clinically stable, with no history of disease exacerbation in the past month; classification on the modified Medical Research Council dyspnea scale less than or equal to 2; not having participated in a supervised and structured physical exercise program at least twice per week for at least 6 weeks within the past 6 months	Participants presenting any clinical condition that may contraindicate or compromise the proposed assessments or the use of blood flow restriction training, such as Peripheral Arterial Occlusive Disease; Deep Vein Thrombosis; Severe Peripheral Neuropathy; Coagulation Disorders	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-23vmpsx	Yoga in Elderly Hypertensive Patients	Not yet recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8888	Effect of Yoga on Blood Pressure in Elderly Hypertensive Patients: A Multicenter Randomized Control Group Study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Instituto do Coração do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	The inclusion criteria are: age 65 years or older; diagnosis of stage 1 or 2 hypertension for more than 6 months; brachial blood pressure measured in the office of less than or equal to 140/90 mmHg under stable antihypertensive medication for at least 2 months; ability to participate in light to moderate physical activity; and provision of free and informed written consent	Exclusion criteria include persistent or permanent atrial fibrillation; insulin-dependent diabetes mellitus; chronic kidney disease with estimated glomerular filtration rate &lt;30 mL/min/1.73 m²; previous stroke; heart failure with left ventricular ejection fraction &lt;40%; recent myocardial infarction (&lt;6 months); symptomatic coronary artery disease; complex ventricular arrhythmias; current smoking; severe cognitive impairment or dementia; musculoskeletal or peripheral vascular conditions limiting exercise; body mass index &gt;35 kg/m²; secondary hypertension; or regular yoga practice within 90 days before study entry	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-562tf5p	Study on Cleaning Cream for Dental Appliance Plaque: Initial Phase	Recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8889	Evaluation of a Cinnamaldehyde-Based Cleansing Cream for Hawley Appliance Cleaning: A Phase I Clinical Study	<NULL>	n/a, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-12	Universidade Federal da Paraíba	<NULL>	<NULL>	<NULL>	Healthy individuals; age 18 years or older; both sexes; ability to understand and sign the Informed Consent Form; availability to use the Hawley appliance and the experimental product according to the study protocol; availability to attend clinical assessments during the study period	History of hypersensitivity or allergic reaction to any component of the experimental product; current use of anti-inflammatory or antimicrobial medications; use of removable dental prostheses or orthodontic appliances; use of chronic topical or systemic medications; presence of systemic diseases that may interfere with clinical evaluation; pregnancy or postpartum period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-5t6m6jh	Comparison of two pain control techniques after minimally invasive kidney removal surgery	Not yet recruiting	Intervention	2026-02-19	<NULL>	<NULL>	8890	Comparison of postoperative analgesia between Quadratus Lumborum Block and Intrathecal Morphine in patients undergoing Minimally Invasive Nephrectomy: a prospective randomized study	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-15	AC Camargo Cancer Center	<NULL>	<NULL>	<NULL>	Adult patients classified as American Society of Anesthesiologists (ASA) physical status I–III undergoing elective laparoscopic partial nephrectomy at the AC Camargo Cancer Center hospital complex	Obese patients (Body Mass Index &gt; 30); patients with ASA physical status &gt; III; those with contraindications to spinal anesthesia or quadratus lumborum block; patients with cognitive impairment precluding reliable assessment using the visual analog scale for pain; patients who develop severe clinical or surgical complications; patients with allergy to morphine or ropivacaine; and patients who refuse to provide written informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-9zx9hy2	Effect of sublingual atropine use on saliva control during intraoral scanning in adults with all teeth	Recruitment completed	Intervention	2026-02-19	<NULL>	<NULL>	8891	Impact of 1% sublingual atropine on intraoral scanning accuracy in fully dentate patients: a triple-blind randomized placebo-controlled clinical trial	<NULL>	n/a, n/a, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Estadual de Ponta Grossa-UEPG	<NULL>	<NULL>	<NULL>	age 18–65 years; American Society of Anesthesiologists ASA physical status I; fully dentate ; 28 permanent teeth excluding third molars; with no untreated caries or extensive restorations; and good oral and periodontal health.	known allergy or hypersensitivity to atropine or placebo components; current use of medications affecting salivary flow;  cholinergic or anticholinergic agents); diagnosis of xerostomia or salivary gland dysfunction;  pregnancy or lactation; significant systemic or neurological conditions affecting saliva production;  orthodontic appliances or fixed prostheses; extensive or defective restorations impacting scanning; active oral lesions or infections; and  strong gag reflex or intolerance to intraoral procedures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-4jwhk24	Knowledge about Depression, Anxiety and Stress with administrative technicians in education at the Federal University of Santa Catarina	Terminated	Intervention	2026-02-19	<NULL>	<NULL>	8892	Psychoeducational intervention on Depression, Anxiety and Stress: A randomized clinical trial with administrative technicians in education at the Federal University of Santa Catarina	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-26	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Over 18 years old; Regular workers, not be away from work.	Workers from outside the university; Under 18 years old.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:10
RBR-73dhv4f	Study on Thyroid Surgery with Endoscopic Access Compared to Conventional	Recruiting	Intervention	2026-02-18	<NULL>	<NULL>	8878	Prospective randomized study of efficacy, safety, cosmetic satisfaction and quality of life of patients undergoing endoscopic thyroidectomy via transvestibular access and comparison with conventional access	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-15	Instituto de Câncer Arnaldo Vieira de Carvalho	<NULL>	<NULL>	<NULL>	Participants over 18 years of age treated at the Instituto do Câncer Arnaldo Vieira de Carvalho; patients with thyroid nodules classified as Bethesda III, IV, V or VI with a maximum diameter of 2 cm; patients with thyroid volume up to 25 cubic centimeters; participants who are aware of the proposed treatments, agree to undergo the procedure and sign the informed consent form (ICF).	Arm Benign Nodules and Arm Malignant Nodules Participants with thyroid nodules Bethesda III, IV, V and VI who at preoperative evaluation present nodules larger than 2 cm or clinical or radiological evidence of thyroid capsule invasion or lymph node metastasis; participants with thyroid diameter greater than 10 cm; participants with acute hyperthyroidism; participants with vocal cord paralysis at preoperative evaluation; participants without cognitive ability to understand the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-6xmsq84	Use of a solution to prevent infections in mouth and throat surgeries	Not yet recruiting	Intervention	2026-02-18	<NULL>	<NULL>	8879	Evaluation of the Efficacy of Prontosan® in Reducing Surgical Site Infections in Upper Aerodigestive Tract Surgeries	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Instituto de Câncer Arnaldo Vieira de Carvalho	<NULL>	<NULL>	<NULL>	Male and female patients aged 18 years or older; histopathologically confirmed diagnosis of squamous cell carcinoma of the oral cavity, lip, oropharynx, hypopharynx, or larynx; candidates for surgery with curative intent, with or without the need for reconstruction; ability to provide a signed Informed Consent Form (ICF)	Active infection at the time of screening; recent use of antibiotics within the last 14 days prior to surgery; severe immunosuppression defined as chronic use of corticosteroids in immunosuppressive doses, recent myelosuppressive chemotherapy or diagnosis of primary or secondary immunodeficiency such as Human Immunodeficiency Virus (HIV) with CD4 count less than 200 cells per cubic millimeter; previous radiotherapy in the proposed surgical region; need for reoperation at the same surgical site; surgery without curative intent such as palliative surgeries; known allergy to any component of the Prontosan solution such as polyhexanide or betaine; inability to provide informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:11
RBR-8by7qqg	Alternative teaching methodology for diagnosing dental enamel defects	Recruitment completed	Intervention	2026-02-18	<NULL>	<NULL>	8880	Improvement in the diagnosis of enamel developmental defects: proposal of an alternative teaching methodology	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-08	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Participants of both genders; of any age; who are undergraduate students in Dentistry at the Faculty of Dentistry of the Federal University of Minas Gerais; Students who have had contact with subjects related to amelogenesis, including Embryology, Pathology, and Dental Anatomy	Students who have already attended a specific class on developmental defects of enamel; Students who have direct contact with this type of pathology in their daily clinical practice for example participants in extension projects involving amelogenesis or those with research projects or undergraduate thesis focused on this theme; Students who present any disability that prevents them from participating in the research activities	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-96nbqtm	Comparing Two Surgical Techniques for Treating Vitiligo: Blister Grafting versus Cell Suspension	Recruitment completed	Intervention	2026-02-18	<NULL>	<NULL>	8881	Comparative Study of Surgical Treatment of Vitiligo: Epidermal Grafting from Blisters versus Grafting of Uncultured Autologous Epidermal Cells Suspension Prepared in Blisters	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-27	Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Patients with a clinical diagnosis of vitiligo, aged 14 years or older; Lesions stable for at least 12 months; Presence of symmetrical lesions in areas suitable for treatment; Availability to undergo narrowband ultraviolet B phototherapy sessions; Signed Informed Consent Form (ICF) and Image Use Authorization Form	Patients younger than 14 years of age; Patients who cannot undergo NB-UVB phototherapy for any reason; Unstable lesions or presence of Koebner phenomenon, confetti-like lesions, or trichrome lesions; Individuals with immunodeficiency, viral or bacterial infection, uncontrolled diabetes mellitus, blood dyscrasias, pregnant or breastfeeding women, or those who have used immunosuppressive medications within the past 30 days; Patients who have undergone phototherapy treatment within the past two months; History of photosensitivity or current use of photosensitizing medications within 30 days prior to initiating phototherapy; History of keloids, hypertrophic scarring, or tendency toward post-inflammatory hyperpigmentation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-9gpxkv3	Effects of same day discharge on safety, quality of life and economical impact and after Cardiac Catheterization	Recruiting	Intervention	2026-02-18	<NULL>	<NULL>	8882	Same day discharge versus overnight observation after Percutaneous Coronary Intervention: economical, safety and quality of life impact	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-01	Associação Paranaense de Cultura	<NULL>	<NULL>	<NULL>	Patients between 18-75 years who have favorable criteria post-intervention, including a Thrombolysis In Myocardial Infarction (TIMI) of 3 in the blood vessel. Absence of occlusion on relevant lateral branches with diameter of ≥ 2 mm. Absence of coronary dissections	ST-segment elevation myocardial infarction (STEMI). Cardiogenic shock. Total obstruction of the targeted blood vessel. Need for left coronary branch or emergency intervention due to persistent chest pain. Clinical instability associated with the reduction of coronary blood flow (TIMI&lt;3). Major bleeding (BARC&gt;1). Prohibition of radial artery access. Need for prolonged anticoagulant therapy. Persistent chest pain. Alterations on the electrocardiogram suggestive of ischemia on the observation period (6 hours after the procedure). Pregnancy. Active malignancies. Simultaneous participation on other clinical trials. Absence of adequate family support	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-2snq3hw	Effect of early high-fat tube feeding on intestinal recovery in hospitalized patients	Not yet recruiting	Intervention	2026-02-18	<NULL>	<NULL>	8883	Impact of early lipid-rich postpyloric enteral nutrition on the intestinal microbiome and functional recovery in patients with intestinal failure	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Hospital Universitario de Caldas	<NULL>	<NULL>	<NULL>	Adult patients aged 18 years or older; patients undergoing major abdominal surgery; admission to the intensive care unit in the immediate postoperative period; diagnosis of acute intestinal failure type I; catabolic response to surgical trauma; medical indication for initiation of early enteral nutrition within the first 24 hours after surgery; hemodynamic stability without requirement for high-dose vasopressors; written informed consent signed by the patient or legal representative	Age under 18 years; chronic intestinal failure or short bowel syndrome; uncontrolled sepsis or septic shock at the time of inclusion; hemodynamic instability defined by norepinephrine requirement greater than 0.1 micrograms per kilogram per minute or vasopressin greater than 1 unit per hour; previously diagnosed inflammatory bowel disease; mechanical intestinal obstruction; intestinal ischemia; active gastrointestinal bleeding; prolonged use of systemic antibiotics for more than 14 days prior to inclusion; clinical or technical contraindication to postpyloric tube placement; pregnancy; concurrent participation in another interventional clinical trial	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-5yy4p9f	Effect of enamel-derived matrix proteins used at different concentrations on bone repair in sinus floor elevation with ceramic material	Not yet recruiting	Intervention	2026-02-16	<NULL>	<NULL>	8877	Effect of enamel-derived matrix proteins at different concentrations on bone repair in sinus floor elevation with biphasic ceramic material - A Randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients with age be between 18 and 60 years; Patients who require unilateral or bilateral maxillary sinus floor elevation for subsequent placement of osseointegrated implants; Patients must have bone availability associated with the alveolar ridge adjacent to the maxillary sinus less than or equal to 3mm; Patients with good systemic health; Patients that present at least 4 months of post-extraction alveolar healing	Smokers; Uncontrolled diabetics; Patients with chronic or aggressive periodontitis; Patients using medications that alter bone metabolism; Patients with chronic upper respiratory tract infections; Patients who chronically use anti-inflammatory drugs and antibiotics; Patients with bruxism; Alcoholics; Substance abusers; Pregnant women or those wishing to become pregnant in the next year; History of radiotherapy treatment in the head and neck region; Patients with pathologies affecting bone metabolism; Patients who have experienced a large rupture of the sinus membrane during surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-75tjp2n	Cardiovascular safety of the herbal medicine Aloysia polystachya (Griseb) Moldenke in controlled hypertensive patients: a randomized, double-blind, placebo-controlled clinical trial	Terminated	Intervention	2026-02-13	<NULL>	<NULL>	8874	Evaluation of the herbal medicine Aloysia Polystachya (griseb) moldenke (verbenaceae) in the treatment of systemic arterial hypertension: a randomized, double-blind, placebo-controlled clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade de Ribeirão Preto - UNAERP	<NULL>	<NULL>	<NULL>	Men, non-pregnant women. Age greater than 18 years and less than or equal to 80 years. Diagnosis of hypertension (systolic blood pressure &gt;= 140 mmHg and/or diastolic blood pressure &gt;= 90 mmHg) and on at least monotherapy for this disease and with good blood pressure control in the last month (assessed by interview and initial blood pressure measurement)	Pregnant or breastfeeding women. Individuals with secondary systemic arterial hypertension. Individuals with paroxysmal or permanent atrial fibrillation. Individuals using any other herbal medicine during the study. Individuals experiencing a serious adverse reaction to the medication such as anaphylaxis, severe hypotension, significant abnormalities in biochemical or hematological tests. Individuals with a BMI greater than or equal to 35. Individuals requesting to be withdrawn from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-10z7snyp	Treatment success and pain after removal of the dental pulp: comparison of two dental cements used in public care	Recruiting	Intervention	2026-02-13	<NULL>	<NULL>	8875	Clinical Success Rate and Absolute Risk of Postoperative Pain in the Comparison of Two National Reparative Cements for Full Pulpotomy in the Treatment of Irreversible Pulpitis in Primary Health Care: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-11	Centro Universitário do Maranhão - UniCEUMA	<NULL>	<NULL>	<NULL>	Systemically healthy patients; of both sexes; aged between 18 and 60 years; presenting permanent anterior or posterior teeth diagnosed with irreversible pulpitis associated with extremely deep caries (involvement of two-thirds or more of the dentin).	Teeth with a negative response to the vitality test; presence of edema; non-restorable crowns and immature roots; insufficient bleeding after pulp exposure suggestive of partial pulp necrosis; inability to control bleeding within 6 minutes; and a history of antibiotic intake within the previous month will also constitute exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-8pzmt86	Clinical evaluation of a nystatin-containing gel for the treatment of denture-associated candidiasis	Recruiting	Intervention	2026-02-13	<NULL>	<NULL>	8876	Mucoadhesive containing nystatin complexed with β-cyclodextrin for the treatmente of Denture Stomatitis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-04	Faculdade de Odontologia de Bauru - Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Individuals who are users of conventional removable maxillary complete dentures; with a clinical diagnosis of denture stomatitis on the palatal mucosa supporting the denture; of both sexes, without age restrictiont; who present a positive smear for Candida on the palatal mucosa and/or on the internal surface of the maxillary complete denture; who agree to participate in the study and sign the Informed Consent Form	Individuals with anemia or uncontrolled endocrine disorders; undergoing antineoplastic treatment with radiotherapy and/or chemotherapy; who have used antibiotics, steroids, or antifungal agents within the last three months; users of the same maxillary complete denture for a period longer than 30 years	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-10zchcdk	Effect of a new peptide on weight control in obese people.	Recruitment completed	Intervention	2026-02-12	<NULL>	<NULL>	8865	Association between oral consumption of White Adipose Tissue Activator Cyclophilin A Peptide and body weight in obese individuals.	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Fundação do abc	<NULL>	<NULL>	<NULL>	Body mass index greater than or equal to 30.0 kilograms per square meter; age between 18 and 60 years; both sexes; glucose level at a maximum of 125 milligrams per deciliter	Patients with neoplasms; recent infections; chronic liver disease; diagnosed depression under treatment; chronic kidney disease; previous bariatric surgery; lung diseases including chronic obstructive pulmonary disease; recent cardiac event within the last six months; rheumatological diseases and other autoimmune diseases; excessive alcohol consumption; dementia; obesity associated with genetic syndromes; decompensated hypothyroidism; menopausal women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-7z47sgw	Impact of Ketamine on Apathy and Depressive Symptoms in Major Neurocognitive Disorder: Randomized, Double-Blind, Placebo-Controlled Study	Recruiting	Intervention	2026-02-12	<NULL>	<NULL>	8866	Effects of Esketamine on Apathy and Depressive Symptoms in Major Neurocognitive Disorder: A Randomized, Double-Blind, Placebo-Controlled Study	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Age sixty years or older; diagnosis of major neurocognitive disorder; minimum score of four points on the Neuropsychiatric Inventory with alteration in the depression and or apathy domain; score on the Clinical Dementia Rating scale less than or equal to two; presence of a formal or informal caregiver able to adequately report the participant clinical status and assist with medication administration control; ability to return for reassessments when required and availability of a telephone for daily contact; signing of the Informed Consent Form agreeing to participate in the study; in case of use of psychotropic medications maintenance of a stable dose for at least thirty days	Clinical instability; use of alcohol other psychoactive substances and or sedative medications; delirium; psychotic disorder or presence of psychotic symptoms; bipolar disorder; unstable medical disease; contraindications to ketamine administration	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-2g42hz7	Transvaginal radiofrequency to treat vaginal symptoms of menopause	Not yet recruiting	Intervention	2026-02-12	<NULL>	<NULL>	8867	Transvaginal radiofrequency to treat geniturinary syndrome of Menopause: Randomized Clinical Trial	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Pontifícia Universidade Católica do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Menopause. Diagnosis of geniturinary síndrome of menopause	Previous pelvic radiotheray. Women using pacemaker	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-6v2mz6f	Polidocanol foam with or without transdermal laser for the treatment of varicose veins	Not yet recruiting	Intervention	2026-02-12	<NULL>	<NULL>	8868	Clinical and Aesthetic Efficacy of Polidocanol Foam Sclerotherapy Associated or Not With Transdermal Nd:YAG Laser in Lower Limb Varicose Veins: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade do Estado do Rio de Janeiro (UERJ) – Hospital Universitário Pedro Ernesto (HUPE)	<NULL>	<NULL>	<NULL>	Age between 21 and 75 years of both sexes. Superficial lower limb tributary varicose veins with a diameter between 2.5 mm and 4.0 mm assessed in the standing position. Tributary vein depth up to 4 mm measured from the anterior wall of the vein to the skin surface. Tributary varicose veins related to the saphenous vein provided that the saphenous vein is competent on Doppler ultrasound. CEAP clinical classification 1 to 3. Body mass index less than 35 kg/m². Signed informed consent form.	Body mass index greater than 35 kg/m². Saphenous vein incompetence requiring prior treatment. CEAP clinical classification 4 to 6. Active venous thromboembolic disease or history of deep vein thrombosis. Active malignancy or immunosuppression. Active rheumatologic diseases or lymphedema. Known allergy to polidocanol. Skin lesions at the site of the vein to be treated. Pregnancy or postpartum period. Inability to understand or sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-2n2kc7x	Evaluation of the effect of a physiotherapy intervention on diaphragm muscle movement in people with chronic respiratory disease using ultrasound analysis	Recruitment completed	Intervention	2026-02-12	<NULL>	<NULL>	8869	Acute Effect of EPAP on Maximal Diaphragmatic Excursion in Patients with Chronic Obstructive Pulmonary Disease: An Analysis with Lung Ultrasonography	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-16	Universidade Federal de Pelotas	<NULL>	<NULL>	<NULL>	Clinical and/or functional diagnosis confirmed of Chronic Obstructive Pulmonary Disease (COPD); hemodynamic stability at the time of protocol application; preserved level of consciousness, with the ability to understand and execute simple verbal commands; functional level that allows positioning at the bedside for the intervention	Patients using continuous oxygen therapy via mask (Venturi, reservoir mask, or high-flow mask);patients who have undergone any recent thoracic or abdominal surgery; tracheostomized patients; patients with ascites; patients with cognitive or neurological impairment that prevents them from understanding or performing the proposed procedures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-23xg9py	Resistance Training with Blood Flow Restriction: Impacts on Function and Muscular Architecture in Upper Limbs	Not yet recruiting	Intervention	2026-02-12	<NULL>	<NULL>	8870	Impact of a Blood Flow Restriction Training on Strength and Muscular Architecture in Upper Limbs	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Estadual Paulista - Faculdade de Filosofia e Ciências -  Campus de Marília	<NULL>	<NULL>	<NULL>	That will be recruited healthy adult volunteers of both sexes, aged 18 to 35 years, who are sedentary or occasionally active in recreational physical activities (standardized based on accelerometry assessment), and with no history of cardiovascular, neuromuscular, or metabolic diseases	Non-inclusion criteria will include the use of medications that influence muscle function, smokers, pregnant women, individuals with recent upper limb injuries, any contraindication to physical exercise, or any previously diagnosed vascular condition. Individuals who consume stimulants, such as caffeine and alcohol, 24 hours prior to the assessments will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-7drv297	The effect of direct current Neuromodulation in children with Autism	Recruitment completed	Intervention	2026-02-12	<NULL>	<NULL>	8871	The effect of Transcranial Direct Current Stimulation combined with dual-task (language-motor) in children with Autism: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal do Amazonas	<NULL>	<NULL>	<NULL>	Clinical diagnosis of Autism Spectrum Disorder (ASD) confirmed by the Modified Checklist for Autism in Toddlers (M-CHAT) and a medical referral for speech-language therapy; symptomatic severity of ASD classified as Level I or II of support, based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); both sexes; normal hearing, as confirmed by a Brainstem Auditory Evoked Potential (BAEP) test; age range from 2 to 3.5 years; not receiving any other concurrent multidisciplinary therapies alongside the research; absence of a cardiac pacemaker, metallic or electronic implant in the body; absence of epilepsy or seizure disorders; absence of other additional disorders or pathologies, such as Down syndrome, Cerebral Palsy, confirmed genetic syndromes, West syndrome, among others	Refusal of the responsible party to sign the informed consent form; low participant tolerance to the intervention, participant refusal of Transcranial Direct Current Stimulation (tDCS) or linguistic-motor therapy; having an interval greater than 3 consecutive days without intervention or 4 staggered days	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-2ycrhb3	Tendon needling versus platelet-rich plasma in gluteal muscle inflammation: clinical trial	Recruiting	Intervention	2026-02-12	<NULL>	<NULL>	8872	Tendon fenestration versus platelet rich plasma in trochanteric syndrome : a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-01	Irmandade da Santa Casa de Misericórdia de São Paulo	<NULL>	<NULL>	<NULL>	Patients aged over 18 years; presence of lateral hip pain for at least 3 months refractory to conservative treatment including physiotherapy and analgesia; score greater than 5 on the visual analog scale for pain during daily activities; clinical diagnosis of greater trochanteric pain syndrome according to the physical examination cluster with tenderness on palpation of the greater trochanter and reproduction of pain with resisted hip abduction in flexion; signature of the informed consent form	Patients allergic to the medications used that cannot be substituted in our service; use of ciprofloxacin in the past year; prior tendon infiltration in the past year; presence of active autoimmune or rheumatologic diseases such as rheumatoid arthritis or systemic lupus erythematosus; active local or systemic infections including osteomyelitis or cellulitis in the hip region; uncontrolled diabetes mellitus with HbA1c greater than or equal to 8%; difficulty or uncertainty in returning for periodic follow-up visits; pregnancy or breastfeeding; chronic use of anticoagulants or other medications that contraindicate the proposed procedures; participation in other concurrent clinical studies that may interfere with the results; degenerative or mechanical joint changes of the hip evidenced on radiographs in the presence of clinical suspicion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-6v8j92w	The effect of Clobetasol solution in the treatment of female pattern baldness	Recruiting	Intervention	2026-02-12	<NULL>	<NULL>	8873	Evaluation of the efficacy of Clobetasol 0.05% solution in the treatment of female pattern alopecia: a proof-of-concept trial	<NULL>	2, n/a, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-01	Departamento de Patologia da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Sign the Free and Informed Consent Form; female; minimum age of 18 years and maximum of 70 years; clinical and trichoscopic diagnosis of Female Pattern Alopecia; Sinclair Scale from II to IV; absence of treatment for Female Pattern Alopecia for more than four months	Specific treatment for female pattern alopecia in the last four months; male; other associated trichological condition that may interfere with the clinical and trichoscopic analysis; hypersensitivity or allergy to any of the substances under study; use of any systemic or topical immunosuppressive substance; use of any topical or oral androgen; severe hair loss that began less than 2 months ago; immunocompromised individuals; coagulation disorders; suspected or confirmed pregnancy; women in the lactation phase	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-6k4mk3b	Randomized and comparative study on surgical treatment of Apical Vaginal Prolapse: abdominal vs. vaginal approach	Not yet recruiting	Intervention	2026-02-11	<NULL>	<NULL>	8858	Randomized study comparing two main surgical approaches in the treatment of Vaginal Prolapses	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women; age 18 years or older; symptomatic apical prolapse; apical prolapse stage II to IV by the POP-Q system; with surgical indication; desire to participate in the study.	Previous neurological disease; apical prolapse stage I or less according to the POP-Q system; previous vaginal prolapse surgery; previous pelvic radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5yh6xkx	Postoperative sensitivity of posterior restorations using a rapid high-intensity light-curing system: a clinical trial	Not yet recruiting	Intervention	2026-02-11	<NULL>	<NULL>	8859	Postoperative sensitivity of restorations of posterior teeth using a rapid high-intensity light-curing system: a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-03	Universidade Estadual de Ponta Grossa	<NULL>	<NULL>	<NULL>	Participants aged between 18 and 70 years; participants must present at least two Class I or Class II restorations in vital teeth; cavities should present similar dimensions and a minimum depth of 3 mm; participants must have at least 20 teeth in functional occlusion; the selected teeth must present adequate proximal contact and confirmed vitality; eligible teeth will include carious lesions or defective existing restorations requiring replacement	Participants with unsatisfactory oral hygiene; participants with chronic or advanced periodontitis; participants that are undergoing fixed orthodontic treatment; exhibit significant occlusal wear in more than 10 posterior teeth; or require endodontic treatment; participants with a history of allergy to any materials used in the protocol; pregnant and lactating women; participants who regularly use anti-inflammatory drugs, analgesics, or psychotropic medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-4w7hzrc	Development in early childhood after the Covid-19 pandemic: a follow-up study	Recruitment completed	Observational	2026-02-11	<NULL>	<NULL>	8860	Assessment of early childhood development after the Covid-19 pandemic: a cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-07-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP - Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Live-born infants and their respective mothers, who were recruited during pregnancy; both sexes; births occurring in partner maternity hospitals	Hospitalization for abortion after fetal death or sexual violence; delivery in another hospital; private insurance births in partner hospitals; obstetric/neonatal emergencies preventing approach; aggressive behavior impairing consent; and women under the prison system	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-7hkhthq	Effects of aminoacid supplementation after resistante exercise	Recruitment completed	Intervention	2026-02-11	<NULL>	<NULL>	8861	Effect of Supplementation with an essential Amino Acid blend enriched with Leucine on the Immune System after resistance exercise: a prospective randomized, double-blind, placebo-controlled study in female gym exercise	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-15	Universidade Federal de São Paulo (UNIFESP) - Hospital São Paulo - Hospital Universitário da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	women aged between 18 and 49 years old, who practice resistance exercise, at least three times a week, for at least one year for one hour/day.	participants who were unable to complete the testing protocol, those who did not adhere to the program, or were injured during the study. women that don´t have between 18 and 49 years old	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-5jv54nm	Fisioterapia para pacientes transplantados	Recruitment completed	Intervention	2026-02-11	<NULL>	<NULL>	8862	Physiotherapy intervention in transplant patients	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade de Brasília	<NULL>	<NULL>	<NULL>	Having undergone kidney transplantation at least six months prior to enrollment; absence of medical contraindications to physical exercise, as determined by medical evaluation; absence of physical impairments that would prevent completion of the assessments or execution of the exercise protocol; adequate cognitive capacity to understand the research procedures and provide informed consent; and access to a digital device with internet connectivity that enables teleconferencing	History of recent cardiac events or clinical decompensation within the previous 1 month; physical, cognitive, and/or social limitations that preclude participation in a physical exercise program or the ability to understand and adhere to device-based monitoring	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-23pfcg5	Use of Zolpidem to help patients with fear of magnetic resonance imaging compared to traditional sedation	Data analysis completed	Intervention	2026-02-11	<NULL>	<NULL>	8863	Zolpidem in the management of claustrophobia during magnetic resonance imaging: a non-inferiority study compared to conventional sedation	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-07-03	Universidade de Sorocaba	<NULL>	<NULL>	<NULL>	Individuals referred to the IDS group for magnetic resonance imaging studies under sedation between July 3, 2023, and August 3, 2024; individuals who report claustrophobia at the time of exam scheduling; age older than 18 years and younger than 70 years.	Individuals who do not provide written informed consent; individuals who do not meet the inclusion criteria; individuals with absolute contraindications to zolpidem use, including hepatic impairment, renal impairment, severe pulmonary diseases, pregnancy, or breastfeeding; age younger than 18 years or older than 70 years; current or chronic use of Zolpidem.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-23chpws	Comparison between two types of medications for pain and swelling control after wisdom teeth removal	Data analysis completed	Intervention	2026-02-11	<NULL>	<NULL>	8864	Evaluation of two drug regimens in the levels of PGE2 after surgical extraction of third molars	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Odontologia de Piracicaba – Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Age between 18 and 30 years; ASA I (American Society of Anesthesiologists physical status classification I); Presence of mandibular third molars in similar positions; Not using any medication routinely or within the week prior to the study; No known allergy to the drugs used in the study; Surgical site without current signs or symptoms of infection.	Patients with a history of pregnancy or lactation; History of gastrointestinal bleeding or peptic ulcer; Allergy to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs); Patients under continuous use of psychoactive drugs, analgesics, or steroidal and nonsteroidal anti-inflammatory agents; Smokers; Presence of postoperative infection signs or symptoms.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:09
RBR-107frvnf	Effect of beetroot juice on the performance of cyclists	Recruiting	Intervention	2026-02-10	<NULL>	<NULL>	8852	The effect of beetroot juice on cardiorespiratory and neuromuscular responses in trained cyclists	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Male participants aged between 20 and 40 years. Volunteers must be active cyclists who perform training sessions at least three times per week, totaling a minimum of 8 hours of weekly cycling sessions. Additionally, they must have at least two years of practical experience in training and competitions within the modality. All participants must be free of pre-existing comorbidities and must sign the Informed Consent Form (ICF) prior to the performance of any study procedures.	Individuals who regularly use tobacco (smokers) or who have sustained any type of musculoskeletal injury within the 40 days prior to the start of testing. Additionally, participants presenting clinical contraindications for maximal physical exertion or those who fail to fully comply with the supplementation protocol and the established washout requirements will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-489jwz6	Simulation-based skills training through deliberate practice for medical students: a comparison between student instructor and expert instructor	Data analysis completed	Intervention	2026-02-10	<NULL>	<NULL>	8853	Skills simulated through deliberate practice among medical students: peer-assisted learning vs. learning with experts	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-07	Universidade de São Paulo - Faculdade de Odontologia de Bauru	<NULL>	<NULL>	<NULL>	men and women; second and third year undergraduate medical students; over 18 years old; had not previously received theoretical or practical training in urinary catheterization	had prior training in urinary catheter insertion; under 18 years old; were already serving as monitors at the Simulation &amp; Skills Laboratory	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5hd4b63	Telerehabilitation and Pain Education Program for Individuals with Knee Osteoarthritis	Recruitment completed	Intervention	2026-02-10	<NULL>	<NULL>	8854	Telerehabilitation and Education Program in Neuroscience of Pain in Individuals with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-27	Escola Superior de Educação Física-Universidade Federal de Pelotas	<NULL>	<NULL>	<NULL>	clinical and or radiological diagnosis of knee osteoarthritis; aged sixty years or older; both sexes; preserved cognitive function; stable clinical conditions; access to smartphone computer or tablet with internet; ability to operate the device independently; self reported pain score equal to or greater than four on the numerical pain rating scale in one or both knees on most days of the week for more than three months	presence of clinical red flags; postoperative status after knee arthroplasty; inability to perform the proposed exercises; other comorbidities preventing participation in the study; previous intra articular corticosteroid injection within the last three months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5rysw9w	Cerebral versus muscles adaptations promoted by two respiratory training programs in endurance–trained individuals	Data analysis completed	Intervention	2026-02-10	<NULL>	<NULL>	8855	Cerebral versus muscles adaptations promoted by two respiratory training programs in endurance–trained individuals	<NULL>	n/a, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Pontificia Universidad Católica do Chile	<NULL>	<NULL>	<NULL>	Age 19 to 45 years; body mass index less than 25;  absence of chronic disease or musculoskeletal injuries within the previous three months prior to enrollment; engagement in regular endurance training (at least 3 sessions per week, 30min or more per session) for at least six months prior to enrollment	Use of any legal or illegal performance–enhancing substances; acute infections or inflammatory processes within two weeks prior to initial testing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-10jx5y6r	Efficacy and safety of hyaluronic acids Juvederm Volux® and Restylane Shaype® in filling the chin	Not yet recruiting	Intervention	2026-02-10	<NULL>	<NULL>	8856	Efficacy and safety of Juvederm Volux and Restylane Shaype in filling the chin region: a clinical study, randomized and double-blind	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Centro Universitário Ingá - UNINGÁ	<NULL>	<NULL>	<NULL>	Volunteers with complaint of chin retrusion, classified as levels II - III on the Galderma chin retrusion scale (GCRS); no previous aesthetic treatments in the mental region.	Volunteers who are pregnant or breastfeeding; with hypersensitivity to hyaluronic acid; who have received aesthetic treatments in the medial and lower region of the face in the last year; who present with autoimmune diseases.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-7nqtpsp	Feasibility of group psychoeducation for bipolar disorder	Recruitment completed	Intervention	2026-02-10	<NULL>	<NULL>	8857	Effectiveness of group psychoeducation in bipolar disorder: a randomized clinical trial based on historical-critical pedagogy and historical-cultural psychology	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-02	Fundação de Ensino e Pesquisa em Ciências da Saúde	<NULL>	<NULL>	<NULL>	Diagnosis of bipolar disorder according to current clinical criteria. Age equal to or greater than eighteen years. Follow-up in a public mental health service. Clinical stability at the time of inclusion, with absence of acute manic or depressive symptoms that would prevent participation in group activities. Sufficient cognitive and communication capacity to understand and participate in the proposed activities. Agreement to participate in the study through signing the Informed Consent Form	Presence of a manic, hypomanic, or severe depressive episode at the time of inclusion. Diagnosis of major neurocognitive disorder or other neurological condition that significantly impairs cognitive performance. Active substance dependence that interferes with participation in group activities. Clinical or psychiatric conditions that prevent regular participation in group sessions. Refusal or inability to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-94d594q	Analgesia in Patients with Chronic Knee Pain	Recruitment completed	Intervention	2026-02-09	<NULL>	<NULL>	8839	Assessment of Analgesia Provided by the IPACK Block in Patients with Knee Osteoarthritis: A Randomized, Controlled, Triple-Blind Clinical Trial	<NULL>	2, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-07-01	Programa de Pós-Graduação em Farmacologia	<NULL>	<NULL>	<NULL>	Patients aged between 18 and 80 years, diagnosed with symptomatic knee osteoarthritis refractory to conventional analgesics and with an indication for total knee arthroplasty (TKA), but unable to undergo the procedure either due to clinical contraindications or prolonged waiting times within the Unified Health System, will be included in this study. Furthermore, only patients who voluntarily agree to participate and sign the informed consent form (ICF) will be considered	Patients with mild or asymptomatic osteoarthritis, defined according to the Kellgren Lawrence Criteria, will be excluded from this study; those who undergo follow up at the algology clinic (due to the possibility of multiple interventions that may interfere with the result); those with neurological deficit (sensory or motor) in the limb; those with signs of infection at the puncture site; those with a history of coagulopathies; those with intellectual deficits in responding to the questionnaires applied	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-9fzpr9h	Bilateral flexible ureteroscopy for kidney stones	Recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8840	Bilateral flexible ureteroscopy for kidney stones using flexible and navigable suction ureteral access sheath (FANS): a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-10	hospital das clinicas da faculdade de medicina da universidade de são paulo	<NULL>	<NULL>	<NULL>	Patients over 18 years of age; Both genders; Stones located in both kidneys with indication for flexible ureterorenolithotripsy; Maximum volume of 8,000 mm3 of kidney stones identified on CT scan	Concomitant urological pathologies, including anatomical malformations; Psychiatric illnesses; Chronic pelvic pain syndrome; Inability to continue outpatient follow-up; Pregnant women; Patients with active urinary tract infection; Patients who are not clinically fit for general anesthesia	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5c9vmfs	Use of low-level laser therapy to reduce dentin hypersensitivity after teeth whitening.	Recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8841	Use of low-level laser therapy as a therapeutic alternative for dentin hypersensitivity after dental bleaching: a clinical study.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-14	Faculdade Educacional de Pato Branco Ltda	<NULL>	<NULL>	<NULL>	Patients who have previously been treated at the Dental School Clinic of the Faculty of Education of Pato Branco; are over 18 years of age; have previously undergone teeth whitening and reported sensitivity after the procedure.	Periodontal disease; pathological or severe hypersensitivity; presence of non-carious cervical lesions; dental cracks; use of analgesics or anti-inflammatory drugs that may interfere with pain perception; pregnant or breastfeeding women; decompensated systemic diseases.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-8d2kp7r	How home-based physical exercises can improve the health and quality of life of frail older adults in Belo Horizonte	Data analysis completed	Intervention	2026-02-09	<NULL>	<NULL>	8842	Effects of Physical Exercise on the experience of older adults in Belo Horizonte at risk and in a situation of Frailty	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Secretaria Municipal de Saúde de Belo Horizonte (SMSA-BH)	<NULL>	<NULL>	<NULL>	Age 60 years or older; the presence of established clinical frailty, as determined by a multidimensional assessment conducted by the research team.	Severe or decompensated clinical comorbidities; advanced cognitive impairment that would prevent them from understanding or performing the proposed intervention; immobility, defined as complete dependence on assistance for ambulation; or absence of a minimum level of family support necessary for participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-3smxct4	Study on the effects of cannabinoids in adolescents with attention deficit and hyperactivity disorder	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8843	Potential effects of cannabinoids in adolescents with attention deficit hyperactivity disorder a double-blind randomized controlled clinical trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Sociedade De Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Adolescents of both sexes, aged 12 to 17 years, residing in the Greater Florianópolis region, with a previous diagnosis of attention deficit and hyperactivity disorder confirmed through the SNAP-IV instrument; absence of other severe mental conditions or physical comorbidities; history of previous treatment with other medications without significant improvement of symptoms; agreement to participate in the study through signing of the Informed Consent Form by the legal guardian and the Assent Form by the adolescent	Use of natural or synthetic cannabinoid substances in the month prior to study initiation; history of intolerance to plant components such as confusion, paranoia, pruritus, excessive drowsiness, vomiting, diarrhea or seizures; presence of any physical comorbidities; presence of severe mental disorder not related to the research objective; moderate or severe cognitive impairment; inadequate completion of the study data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-4fvh994	Effect of cold plasma use on pain and chewing during maxillary expansion	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8844	Role of inflammatory mediators, pain perception and masticatory quality in atmospheric cold plasma therapy associated with rapid maxillary expansion: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Volunteers with a clinical diagnosis of unilateral or bilateral posterior crossbite and/or maxillary atresia; Class I or Class II dental malocclusion; first or intertransitional period of mixed dentition; absence of extensive caries lesions and periodontal disease, good general and oral health; absence of previous orthodontic treatment	Volunteers with conditions that compromise oral health at the time of the initial evaluation; with systemic diseases or general health conditions that may interfere with treatment or clinical evaluations; with a history of previous orthodontic treatment; with craniofacial anomalies, genetic syndromes, or cleft lip and palate; continuous or recent use of medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-3csjgb8	Effects of topical application of Silver-Nimesulide Complex in the Treatment of Patients with Squamous Cell Carcinoma of the Skin	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8845	Effects of topical application of Silver-Nimesulide Complex in the Treatment of Patients with Skin Squamous Cell Carcinoma: Phase I/II Study	<NULL>	1-2, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-12	Universidade Estadual de Campinas - UNICAMP	<NULL>	<NULL>	<NULL>	Men and women aged 18 years or older and under 90 years; confirmed diagnosis of cutaneous squamous cell carcinoma. Tumors with a minimum diameter of 1cm and superficially located in the skin. Surgical tumor resection previously scheduled; ensuring a minimum interval of 42 days between the initiation of treatment with the silver–nimesulide biocurative (CB-Ag-NMS) and the surgical procedure. Signed or recorded Informed Consent Form (ICF)	Participants with lesions located on the face. Lesions near superficial blood vessels. Ulcerated tumor. Dermatological comorbidities that may interfere with clinical evaluation. Known hypersensitivity to silver; nimesulide or adhesive materials. Pregnant or breastfeeding women. Immunosuppressed individuals. Participants who do not have a previously scheduled tumor resection surgery at the Institution	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-3gn53r9	The supplement Tributyrin and gut health in patients with digestive Cancer	Recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8846	Effect of Tributyrin supplementation on the gut microbiota of patients with gastrointestinal Cancer	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-31	Faculdade de Medicina da Universidade de São Paulo - FMUSP	<NULL>	<NULL>	<NULL>	Patients over 18 years of age; diagnosed with gastric or colorectal malignancy; indicated for curative surgery	Individuals with less than 30 days available for supplementation; patients undergoing chemotherapy; continuous use of opioids; anti-inflammatory drugs or corticosteroids; use of antibiotics; prebiotics; probiotics or synbiotics within the last three months; presence of hepatic or renal failure; diagnosis of chronic inflammatory disease; comorbidities associated with cachexia such as rheumatoid arthritis; chronic obstructive pulmonary disease; acquired immunodeficiency syndrome; autoimmune diseases; dietary or therapeutic restrictions that interfere with the study parameters	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-7mmkzt7	Effect of Intraoral Mandibular Advancement Intraoral Appliance (OAm) therapy on Obstructive Sleep Apnea, systemic status,   periodontium of pregnant women and its influence on the fetus and newborn: clinical-laboratory analysis of medical and dental images	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8847	Effect of the Intraoral Mandibular Advancement Device (AIOam) and the Silicone Occlusal Splint (POs) in pregnant women with Obstructive Sleep Apnea and on fetal growth: clinical-laboratory and medical-dental imaging analyses	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Instituto de Ciências e Tecnologia da Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Chronic hypertensive pregnant women with OSA (Apnea-Hypopnea Index AHI &gt; 5 and &lt; 30 events/hour); chronic hypertensive pregnant women with 20 to 22 weeks of gestation; oxyhemoglobin desaturation index (ODI) ≥ 5 events/hour; chronic hypertensive pregnant women aged 20 to 35 years; chronic hypertensive pregnant women with healthy periodontium and absence of caries; nulliparous and multiparous chronic hypertensive pregnant women; sign the Free and Informed Consent Form	Women with pregnancy period &lt; 20 weeks and &gt; 22 weeks with apnea hypopnea index &gt;30/h; with dessaturation index &gt;30/h or with more than 10% of desaturation time &lt;90%; active periodontal disease; severe temporomandibular disorder; drink alcohol; smoke and use drugs; use anti-inflammatory drugs; hormonal therapy; psychiatric disorders; infectious diseases; hematological diseases; clinical history of using orthodontic appliances less than 6 months before the proposed study;  twin pregnancies; using antidepressants; using in vitro fertilization	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5g3jvz7	Video for patient education before cardiac surgery: randomized clinical trial	Recruitment completed	Intervention	2026-02-09	<NULL>	<NULL>	8848	Care-educational technology for patients in the preoperative period of cardiac surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Programa de Pós-Graduação em Enfermagem	<NULL>	<NULL>	<NULL>	Patients admitted for surgical procedure of myocardial revascularization surgery with or without extracorporeal circulation; oriented and conscious patients; who agree to participate in the study; who have not had previous surgery canceled; with hospitalization time of less than 15 days; aged 18 years or older, of both sexes	Patients who have undergone any previous surgical procedure; who are hospitalized for other associated surgeries; who have any neurological or psychological disorder capable of altering the understanding found in the diagnosis in the patient&apos;s medical record	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-4qb9bqy	Effect of new dentures on the appearance of the face in people without teeth	Recruitment completed	Intervention	2026-02-09	<NULL>	<NULL>	8849	Effect of new complete dentures placement on facial parameters in complete denture wearers	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Completely edentulous patients; of both genders; over 18 years of age; requiring new complete dentures; in good general health; without intraoral lesions or pathologies; without alterations in the perioral musculature upon palpation	Patients with health problems that may hinder or prevent attendance at the dental school for prosthetic treatment, follow-up appointments, or study evaluations; with severely resorbed ridges; with palatal tori requiring surgical removal	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5yk8j2w	How Pilates training on equipment can improve functional capacity, quality of life, balance, and muscle strength in very old adults: a controlled clinical study	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8850	Effects of Pilates training using equipment on functional capacity, quality of life, balance, and muscle strength in long-lived elderly individuals: a controlled clinical trial	<NULL>	n/a, non-randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Universidade Federal do Amazonas	<NULL>	<NULL>	<NULL>	male and female individuals aged 80 years or older, proven by presenting an official document at the time of enrollment	Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, walker, crutch, metallic knee and hip prostheses, visual impairment, wheelchair user	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-8kyp7kz	Therapeutic Light to ease Pelvic Pain and improve women’s quality of life	Not yet recruiting	Intervention	2026-02-09	<NULL>	<NULL>	8851	Effect of Photobiomodulation on Chronic Pelvic Pain and quality of life in women of reproductive age: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Faculdade de Ciências da Saúde do Trairi	<NULL>	<NULL>	<NULL>	Women aged 18 to 49 years who report chronic pelvic pain will be included in this study. Participants must report non-cyclical pain located in the pelvic region, with a duration of at least 3 months, and must be available to attend the in-person sessions according to the study schedule.	Women will be excluded if they present malignancy (cancer); epilepsy; cardiac arrhythmia; cognitive impairment; difficulty understanding instructions and/or using the assessment instruments; history of pelvic surgery within the past year; chronic infection; pregnancy; intact hymen. Participants included in the study must not be undergoing any other type of treatment for chronic pelvic pain, except for pharmacological treatment.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-94p64cm	How to improve nursing support for those struggling to manage their health while living with Human Immunodeficiency Virus: A study based on care theories	Not yet recruiting	Intervention	2026-02-07	<NULL>	<NULL>	8838	Validation of the nursing diagnosis Ineffective Health Self-Management for the care of people living with Human Immunodeficiency Virus in light of a middle-range theory	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-10	Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	or conceptual validation nurses or nursing undergraduates with clinical theoretical or research experience with people living with the human immunodeficiency virus and or clinical theoretical or research experience with nursing diagnoses of the North American Nursing Diagnosis Association International will be elected. For clinical validation with nurses all nurses from the Giselda Trigueiro Hospital who voluntarily agree to participate in the research and have an active employment bond with the Giselda Trigueiro Hospital will be included. For clinical validation with patients those who are eighteen years of age or older at the time of collection have a positive diagnosis for human immunodeficiency virus and are hospitalized during the data collection period will be included in the study.	For conceptual validation individuals who do not respond to the research in a timely manner will be excluded. For clinical validation those nursing professionals who are on vacation or are away from professional practice during data collection as well as those who have less than one year of professional experience with People Living with Human Immunodeficiency Virus will be excluded from the research. For exclusion in the patient group patients diagnosed with Human Immunodeficiency Virus and neoplasia neurological comorbidity or similar condition that may affect the result of the collection due to cognitive and speech disability will be adopted patients hospitalized in isolation will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-6hv63hw	Use of laser on the ear to relieve anxiety after childbirth	Not yet recruiting	Intervention	2026-02-06	<NULL>	<NULL>	8837	Effect of Laser Auriculotherapy on the management of anxiety in postpartum women: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Postpartum women aged 18 years or older; under co-admission in the Kangaroo Neonatal Intermediate Care Unit of the Januário Cicco Maternity School at the Federal University of Rio Grande do Norte; accompanying their newborns; with adequate clinical and cognitive conditions; with time between childbirth and the newborn’s admission to the UCINCa between 48 hours and 10 days	Infection, inflammation, injury, or any anatomical alteration of the auricular pavilion that makes auriculotherapy application unfeasible; planned hospital discharge before completion of the scheduled intervention sessions; refusal to participate in the application of the technique, including the sham modality	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5gxdv9y	Acute effects of Passiflora incarnata on endothelial function, blood pressure, and heart rate in healthy adults	Not yet recruiting	Intervention	2026-02-05	<NULL>	<NULL>	8829	Acute effect of Passiflora incarnata on endothelial and hemodynamic function in healthy adults: a randomized, double-blind, crossover, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Adults; of both sexes; aged between 18 and 40 years, will be included	Participants will be excluded if they have a history of chronic diseases; are smokers; use medications on a continuous basis that may influence vascular responses; have a known allergy to Passiflora incarnata or to any component of the formulation; use drugs with sedative effects, such as pentobarbital and hexobarbital; anticoagulants such as warfarin; or monoamine oxidase inhibitors (MAOIs), including isocarboxazid, phenelzine, and tranylcypromine, due to their potential to interfere with the hemodynamic responses assessed and to increase the risks involved in the study. In addition, participants who regularly use antioxidant supplements or nitrates, or who have consumed polyphenol-rich foods (e.g., beetroot, chocolate, green tea, citrus fruits) within the 24 hours preceding the experiment will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-9qwz6r4	Study comparing the effectiveness of Tea Tree Oil and Chlorhexidine in reducing dental biofilm	Data analysis completed	Intervention	2026-02-05	<NULL>	<NULL>	8830	Comparative study of the effectiveness of Tea Tree Oil and Chlorhexidine in dental biofilm control: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-01	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Age equal to or over 18 years old; gingival bleeding within ten seconds after removing the probe from the gingival sulcus; presence of dental biofilm; tooth loss due to extraction for orthodontic treatment; both sexes	Smokers; alcoholics; diabetes mellitus; allergic to one of the study substances; use of orthodontic appliances; use of mouthwash or antimicrobial substance for at least two weeks before the start of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-29598bx	Heart damage after surgery in patients with cancer: how often does it happen and what are the risks?	Recruiting	Observational	2026-02-05	<NULL>	<NULL>	8831	Myocardial Injury After Noncardiac Surgery in Patients With Cancer: Incidence, Risk Factors, and Prognostic Impact – A Prospective Cohort Study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Hospital Israelita Albert Einstein	<NULL>	<NULL>	<NULL>	Patients with cancer under active treatment (active oncologic disease); undergoing elective, urgent, or emergency noncardiac surgery requiring general anesthesia; admitted to the intensive care unit in the postoperative period; classified as intermediate- or high-risk surgical candidates at preoperative outpatient assessment, defined as Revised Cardiac Risk Index (Lee score) &gt; 2 or moderate-or-higher risk of cardiac complications according to the ACS-NSQIP calculator; or, in the absence of formal preoperative evaluation, age &gt; 65 years or age &gt; 45 years plus at least one cardiovascular risk factor (peripheral arterial disease, coronary artery disease, prior stroke, diabetes mellitus, or systemic arterial hypertension).	Patients younger than 45 years; refusal to participate by the patient or their legal representative; troponin elevation attributable to a non-ischemic cause, according to predefined protocol criteria (e.g., pulmonary embolism, myocarditis, tachyarrhythmias); patients undergoing more than one noncardiac surgery within the same calendar year.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-3dfgz3w	Ultrasound assessment of the effects of respiratory physiotherapy on diaphragmatic function in children with respiratory infections	Recruitment completed	Intervention	2026-02-05	<NULL>	<NULL>	8832	Effects of the EFE Technique on Invention and Diaphragmatic Thickness in Pediatric Patients with Respiratory Infections: Assessment by Lung Ultrasound	<NULL>	n/a, n/a, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Pelotas	<NULL>	<NULL>	<NULL>	The study will include individuals of both sexes, under 12 years of age, who are hospitalized at the UFPel Teaching Hospital and diagnosed with some type of acute respiratory infection	Individuals who have undergone any recent thoracic or abdominal surgery, or who have contraindications to the proposed technique due to any other relevant clinical factors, such as rib fractures, severe cardiovascular disease, acute asthma exacerbation, and elevated intracranial pressure, will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-23wvcfk	Effect of consuming foods with health-promoting properties on satiety, blood sugar and lipid levels	Data analysis completed	Intervention	2026-02-05	<NULL>	<NULL>	8833	Effect of functional foods and nutraceuticals on satiety, glycemic control, and lipid profile	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Goiás	<NULL>	<NULL>	<NULL>	Individuals aged 20 to 50 years; both sexes; diagnosed with type 2 diabetes mellitus; under medical supervision and using a stable dose of oral hypoglycemic agents for at least six months	Pregnant women; individuals with dietary restrictions or participants in dietary restriction programs; individuals with autoimmune diseases, hepatic or renal diseases, or infectious diseases; individuals with food allergies; use of anti-inflammatory drugs, antibiotics, immunosuppressive agents, or nutritional supplements; chronic alcohol users; failure to complete all study assessments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-8ytv6qy	Impact of a care plan after hospital discharge on the lives of patients who need special care	Recruitment completed	Intervention	2026-02-05	<NULL>	<NULL>	8834	Impact of implementing a Transitional Care pPan in patients with complex needs	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de São Paulo - Unifesp	<NULL>	<NULL>	<NULL>	Adult patients (age equal to or greater than 18 years); both sexes; admitted to wards, intensive care units, or the Emergency Department of Hospital São Paulo with complex needs; who are scheduled for hospital discharge and for whom the responsible physician or nurse has requested an evaluation by the transition of care team	Previously included patients who are unable to understand the provided guidance; without a telephone; or who refuse to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-108sskhg	The action of Elastic Bandage on pain, edema and functional capacity in women after cesarean section	Not yet recruiting	Intervention	2026-02-05	<NULL>	<NULL>	8835	Effect of Abdominal Taping on pain, edema and functional capacity in women in the immediate post-partum period by cesarean section: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-17	Faculdade de Educação Física e Fisioterapia	<NULL>	<NULL>	<NULL>	Female participants. Age between 18 and 45 years. Be in the immediate postpartum period (first 48 hours). Surgical delivery route (cesarean section) of a single fetus	Presence of significant muscle dysfunctions. Presence of skin lesions in the abdominal region. Presence of dehiscence, necrosis and/or opening of stitches in the scar incision. Allergies to elastic bandage. Presence of neurological and/or cognitive deficiencies that prevent understanding of the proposed procedures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-7rztcbk	Music to reduce stress and anxiety during the first chemotherapy session in women with Breast Cancer	Not yet recruiting	Intervention	2026-02-05	<NULL>	<NULL>	8836	Efficacy of using Music to reduce stress and anxiety in Breast Cancer patients undergoing their first chemotherapy session: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-05	Karena Cristina da Silva Leal	<NULL>	<NULL>	<NULL>	Patients with breast cancer and HER2-negative disease admitted to the outpatient clinic to undergo neoadjuvant ACT treatment (NSABP B-27) for the first time; beginning oncological treatment at the institution for the first time through the Brazilian Unified Health System; women; aged 18 years or older; and reporting that they enjoy music	Patients with any neurological and/or cognitive impairment that may compromise understanding and the appropriate use of the assessment scale at the required moment; patients with hearing impairment; patients already undergoing continuation of chemotherapy treatment; and patients who use anxiolytics, antidepressants, or lithium on a continuous basis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-6pjw7g8	Art as a therapeutic resource for alleviating anxiety in elderly residents of long-term care facilities	Not yet recruiting	Intervention	2026-02-04	<NULL>	<NULL>	8826	Art therapy as a tool for reducing Anxiety levels in elderly people living in long-term care facilities: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Cruzeiro do Sul Educacional S.A	<NULL>	<NULL>	<NULL>	Moderate or high levels of anxiety; no cognitive impairment; assessed by the Mini-Mental State Examination (MMSE); no hemodynamic instability; willingness to participate in all intervention sessions; no severe sensory alterations	Elderly individuals with severe communication impairments; Diagnosis of advanced neurodegenerative diseases; Previous and regular participation in art therapy practices; Under pharmacological treatment for anxiety; With severe behavioral changes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-24mkxp8	Use of Dialkyl Carbamoyl Chloride (DACC) to aid in the healing of challenging wounds	Not yet recruiting	Intervention	2026-02-04	<NULL>	<NULL>	8827	Use of Dialkyl Carbamoyl Chloride (DACC) in the prevention and treatment of Hard-to-Heal Wounds	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	<NULL>	<NULL>	<NULL>	Postoperative cardiac surgery patients; both genders; over 18 years of age; who are not immunosuppressed; who do not abuse psychoactive substances	Known allergy or sensitivity to the components of the Dialkyl Carbamoyl Chloride (DACC) dressing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-10scfvch	Comparison of Resistance and Combined Training in older adults with Type 2 Diabetes Mellitus	Recruiting	Intervention	2026-02-04	<NULL>	<NULL>	8828	Comparison of Resistance and Combined Training on metabolic profile, physical performance, body composition, and capillary blood glucose behavior in older adults with Type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-15	Universidade São Judas Tadeu	<NULL>	<NULL>	<NULL>	Men; aged between 65 and 79 years; with type 2 Diabetes Mellitus with a stable dose of medication (oral antidiabetics or insulin or a combination of both) for three or more months; glycated hemoglobin between 6 and 10.0%; without musculoskeletal pain, disabling motor disorders, cardiovascular or musculoskeletal conditions that prevented the performance of resistance or combined training; had not participated in any resistance training or combined training practice at least three months before the start of the pre-intervention tests; normal cognitive level, assessed by the Montreal Cognitive Assessment (MoCA), respecting the cut-off levels according to the participant&apos;s education level	Impossibility of carrying out assessments and reassessments; during the training period they had more than three absences; they had any adverse events related to musculoskeletal pain or worsening of symptoms or signs of pre-existing diseases, mainly changes in systemic blood pressure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-109s4k92	Study on the effects of exercise program on unstable versus stable surface in preventing falls and improving balance in elderly women in nursing homes	Not yet recruiting	Intervention	2026-02-03	<NULL>	<NULL>	8823	Comparison of the effects of the Otago program on unstable versus stable surfaces on fall risk and balance in institutionalized elderly women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-20	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Forty elderly women; clinically stable; will be included in the study; divided into two groups: 20 for the Otago group and 20 for the Otago group with an unstable base.	Moderate to severe dementia according to the Mini-Mental State Examination score (include the raw score), uncorrected visual disorders, motor sequelae from neurological disorders or other musculoskeletal conditions that prevent participation in the program.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-2d3pb5t	Sexual dysfunction in patients with Myopathies	Recruiting	Intervention	2026-02-03	<NULL>	<NULL>	8824	Sexual Dysfunction in patients with Systemic Autoimmune Myopathies	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-03	Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Older than 18 years; women; diagnosis of systemic autoimmune myopathies; presenting sexual dysfunction	Pregnant; history of gynecological neoplasia; pelvic irradiation; gynecological tract infections; sexually transmitted diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-34mrqhc	Study evaluating the safety and efficacy of corneal ring implantation.	Recruiting	Intervention	2026-02-03	<NULL>	<NULL>	8825	Prospective study evaluating the safety, effectiveness, and usability of BICS	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-19	Hospital das Clínicas - Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Patients diagnosed with keratoconus; keratoconus in patients intolerant to contact lenses; pellucid marginal degeneration; decentration of the posterior highest point equal to or greater than 1.25 mm from the center; keratometry with a maximum mean keratometry (Kmean) of 58 µm; minimum corneal thickness of 420 µm in the 5 mm optical zone; both sexes; age 18 years or older; patients willing and able to undergo clinical examinations for follow-up for a period of 1 year after surgery.	Patients without a clinical indication for treatment with intrastromal corneal ring implantation; vulnerable groups, including individuals with reduced or impaired capacity for self-determination, especially with regard to free and informed consent.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-5rc2x9b	Third-Line Treatments for Neurogenic Overactive Bladder	Recruiting	Observational	2026-02-02	<NULL>	<NULL>	8820	Third-line treatments for Neurogenic Detrusor Overactivity: clinical outcomes, complications, and impact on quality of life	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-13	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients followed at the Voiding Dysfunction and Neuro-urology outpatient clinic; treated with intravesical application of botulinum toxin and or bladder augmentation for neurogenic detrusor overactivity; between 1990 and the present; who agree to participate; who consent to complete the study questionnaires	Patients who refuse or are unable to participate or complete the questionnaires; patients who received botulinum toxin or underwent bladder augmentation for non-neurogenic causes; patients who were treated with therapeutic modalities that are not part of the objectives of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-4z8cq3p	Impact of a virtual de platform on occupational stress and metabolic syndrome SeMEar health: a randomized clinical trial	Not yet recruiting	Intervention	2026-02-02	<NULL>	<NULL>	8821	Virtual platform for occupational stress and metabolic syndrome SeMEar health: creation and validation	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade do Estado da Bahia	<NULL>	<NULL>	<NULL>	Age 18 or older; both genders; occupational stress; presence of burnout symptoms (in all three dimensions); metabolic syndrome; willingness to voluntarily participate in the program	Those who participated in another study/body-mind therapy intervention in the last month; pregnant women; those on leave from work; those who do not complete all stages of the intervention	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-95wytq8	Active Oxygen Gel to improve healing and reduce pain after Frenectomy	Recruiting	Intervention	2026-02-02	<NULL>	<NULL>	8822	Effects of Active Oxygen-Releasing Gel and Lactoferrin on the healing and analgesic process in Frenectomy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-07	Universidad Jose Antonio Paez	<NULL>	<NULL>	<NULL>	Patients of both sexes; older than 18 years; without systemic diseases; with a diagnosis of papillary frenulum or aberrant frenulum or with an indication for frenectomy due to orthodontic, prosthetic or aesthetic reasons; who voluntarily agree to participate and sign the informed consent form	Patients under legal age; patients with systemic inflammatory diseases; patients with smoking-related disease or conditions that interfere with the healing process; diabetic patients; patients with periodontal disease; patients undergoing chemotherapy or radiotherapy to the head and neck region	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-10mng9xp	Evaluation of vaginal flora, hormonal cytology, and vaginal biopsy in menopausal women comparing the use of non-ablative radiofrequency, CO₂ laser, and vaginal estrogen	Not yet recruiting	Intervention	2026-01-30	<NULL>	<NULL>	8816	Evaluation of the vaginal microbiome, hormonal citology and vaginal histology in postmenopausal women following non-ablative radiofrequency, CO₂ laser therapy, and vaginal estrogen	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-27	Maternidade Escola Assis Chateaubriand / MEAC ( maternidade escola Assis Chateaubriand)/ UFC( universidade federal do Ceará)	<NULL>	<NULL>	<NULL>	Healthy menopausal women; with or without an active sex life; complaints related to genitourinary atrophy	Oncotic cytology with atypical cells precursors to cervical cancer; use of hormone therapy in the last 6 months (topical or systemic); use of vaginal lubricants or moisturizers in the last month; active genital infections	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-3cvt7vb	Laser therapy as a preventive strategy for taste alterations in head and neck Cancer patients undergoing Radiotherapy: a randomized clinical trial	Not yet recruiting	Intervention	2026-01-30	<NULL>	<NULL>	8817	Use of Photobiomodulation to prevent taste alterations in patients with head and neck Cancer undergoing Radiotherapy	<NULL>	2-3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-06	Universidade Federal de Pernambuco	<NULL>	<NULL>	<NULL>	Patients with performance status 0 and 1; aged 18 to 70 years; diagnosed with head and neck cancer; radiation dose of 40 Grays or more	Diagnosis of anemia; uncontrolled diabetes; history of use of medications that significantly altered salivary flow or saliva composition or taste; use of centrally acting analgesics or anxiolytics and antidepressants; resection in the tongue region; tumors in the tongue and base of the tongue and floor of the mouth or nearby regions that make the application of the photobiomodulation protocol unfeasible	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-9kjkfmf	Evaluation of the lowest effective dose of Anesthetic in a Nerve Block for pain control after Breast Surgery	Data analysis completed	Intervention	2026-01-30	<NULL>	<NULL>	8818	Evaluation of the minimum effective dose of Levobupivacaine in Serratus Anterior Plane Block for analgesia in patients undergoing Breast Surgery	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-10	Hospital do Câncer da Fundação Cristiano Varella	<NULL>	<NULL>	<NULL>	Female patients aged 18 to 75 years; American Society of Anesthesiologists (ASA) physical status I or II; indication for breast surgery (e.g., sectorectomy, quadrantectomy), with or without axillary approach; procedure performed under general anesthesia; eligible for ultrasound-guided serratus anterior plane block; ability to understand and respond to the numeric pain rating scale; and provision of written informed consent	Infection and/or local pain at the block site; allergy to any medication used during anesthesia; renal dysfunction; coagulopathy; body mass index (BMI) greater than 40 kg/m²; severe heart disease; inability or lack of understanding of the assessment tool; or refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-35cj5s6	Transcranial Electrical Stimulation combined with physical exercise in elderly people with cognitive impairment.	Not yet recruiting	Intervention	2026-01-30	<NULL>	<NULL>	8819	Transcranial Direct Current Stimulation combined with physical exercise in elderly individuals with Mild Cognitive Impairment	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-05	Departamento de Ciências do Movimento Humano- Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Elderly individuals over 60 years of age; female; independent; sedentary and/or insufficiently active; not using an assistive device for walking (e.g., cane or walker), with Mild Cognitive Impairment assessed using the Montreal Cognitive Assessment - MoCA with a cutoff score of 25 points; for individuals with 12 years or less of schooling, one additional point should be added; availability to participate in all treatment and evaluation sessions	Elderly individuals with neurological diseases (e.g., Alzheimer&apos;s, Parkinson&apos;s, Stroke, Vertigo, Dementia); hypertensive individuals; contraindications for the use of Transcranial Direct Current Stimulation - tDCS (e.g., use of psychotropic drugs, history of uncontrolled seizures, presence of metallic implants or electrical devices in the skull, presence of unhealed wounds on the scalp)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-10c2zysn	Effects of Two Pilates Method Exercise Protocols on the Treatment of Gestational Lumbopelvic Pain: A Randomized Controlled Trial	Not yet recruiting	Intervention	2026-01-29	<NULL>	<NULL>	8812	Effects of Two Pilates Method Exercise Protocols on the Treatment of Gestational Lumbopelvic Pain: A Randomized Controlled Trial	<NULL>	n/a, n/a, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia – FAEFI/UFU	<NULL>	<NULL>	<NULL>	Pregnant women aged between 18 and 40 years; gestational age between 20 weeks and 0 days and 24 weeks and 6 days at the time of recruitment; clinical diagnosis of lumbopelvic pain with onset in the current pregnancy; pain score equal to or greater than 3 on the 11-point Numerical Rating Scale regarding the last week; presence of clinically relevant functional disability defined by the Roland-Morris Disability Questionnaire with a score equal to or greater than 14; presentation of formal medical clearance from the obstetrician for physical exercise; agreement to participate in the research by signing the Informed Consent Form	Pregnant women with bone deformities ; presence of any other condition causing lumbopelvic pain, such as herniated disc, previous lumbar surgery, and ankylosing spondylitis ; presence of major muscle dysfunctions ; neurological or cognitive impairments that prevent understanding of the proposed procedures ; volunteers visibly under the influence of drugs or alcohol ; current physical injury or medical condition that prevents exercise, such as heart conditions, hypertension, diabetes requiring insulin, kidney disease, cancer, and severe asthma ; conditions that increase the risk of illness, such as epilepsy requiring pharmacotherapy and hyperemesis gravidarum ; regular practice of Pilates, Yoga, or core strengthening in the six months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-2g7rqt7	How bar position in the squat influences gluteus maximus strength and growth	Recruitment completed	Intervention	2026-01-29	<NULL>	<NULL>	8813	Effects of bar placement in the squat on force and regional hypertrophy of the gluteus maximus	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo - USP	<NULL>	<NULL>	<NULL>	Volunteers aged between 18 and 39 years; have previous experience with resistance training but have not practiced it for at least six months; present negative responses to all items of the Physical Activity Readiness Questionnaire PAR-Q; have no health problems that prevent participation in the proposed training; do not use anabolic steroids	Volunteers who start creatine supplementation during the training period; start anabolic steroid use during the training period; perform other hip extension exercises except those provided in the study training program; perform hip abduction exercises; present acute or chronic musculoskeletal injuries that may compromise exercise performance training progression or safe participation in any phase of the proposed training program	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-4s9zftf	Effects of Pre-exhaustion versus Traditional resistance training on Hypertrophy and Strength in women	Recruitment completed	Intervention	2026-01-29	<NULL>	<NULL>	8814	Effects of Pre-exhaustion versus Traditional resistance training on quadriceps Hypertrophy in women.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-14	Universidade Federal de Pernambuco - Campos Recife	<NULL>	<NULL>	<NULL>	All participants must meet the following requirements: healthy women aged 18 to 35; composed exclusively of women; untrained in resistance training (n=75), which is characterized by the absence of resistance training practice in the last 12 months; no recent history or evidence of abuse of legal or illegal psychoactive drugs; no use of any ergogenic aid (anabolic steroids within the last year; creatine within the last month; caffeine within the last 2 days; beta-alanine within the last 2 days; bicarbonate within the last 2 days; nitrate within the last 7 days)	Participants who withdraw will be excluded; as will those who suffer any type of injury during the data collection period; and participants who answer &quot;YES&quot; to any question on the Physical Activity Readiness Questionnaire (PAR-Q)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-3vzkb42	Mobile app to help families increase children’s fruit intake	Not yet recruiting	Intervention	2026-01-29	<NULL>	<NULL>	8815	Digital intervention for promote fruit consumption in children with a focus on parents: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-08-01	Faculdade de Enfermagem da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Parents and/or guardians of children aged 2 to 5 years; who have effective verbal communication skills and access to a mobile device compatible with the application and the internet	Parents and/or guardians of children with any disease or health condition requiring a specific diet; or restricting fruit consumption (as reported by the parents/guardians)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-6f5jx7p	Use of educational technologies to control urine loss after Prostate Surgery	Not yet recruiting	Intervention	2026-01-28	<NULL>	<NULL>	8808	Effectiveness, feasibility and acceptability of educational technologies in a cognitive-behavioral program for the management of Urinary Incontinence after Radical Prostatectomy: a multicenter clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Men aged 18 years or older; presenting mild, moderate, or severe urinary incontinence, assessed using the Pad test; self-reporting preserved locomotor, visual, and auditory abilities; presenting preserved cognitive function, verified through the Six-Item Cognitive Impairment Test; without a history of urinary incontinence prior to the surgical procedure; presenting absence of postoperative complications such as urethral stricture, urinary retention, rectourethral fistula, or severe urinary tract infection; being without the use of an indwelling urinary catheter for a minimum period of 15 days after surgery, allowing for the development of self-perception regarding clinical conditions and physical adaptation to the postoperative impact; having undergone radical prostatectomy within a maximum of six months; and demonstrating willingness to participate in the scheduled face-to-face meetings	Individuals with spinal cord injury or diseases affecting urinary control; with a history of bladder and/or prostate surgery; reporting not using pads/liners/diapers; initiating chemotherapy or radiotherapy treatment during the intervention period; missing two consecutive face-to-face sessions; hospitalization due to postoperative complications; presenting intercurrences such as infection episodes or urethral stricture; and requiring reinsertion of an indwelling urinary catheter due to bleeding or urinary retention caused by clots	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-9zmnvn6	Evaluation of the benefit of treating repetitive motion disorders in moderate to advanced dementia with the combined use of pramipexole and transcranial magnetic stimulation in elderly individuals	Data analysis completed	Intervention	2026-01-28	<NULL>	<NULL>	8809	Evaluation of the new applicability of the combined use of Pramipexole and Transcranial Magnetic Stimulation in Aberrant Motor Behavior in elderly people with moderate to advanced Dementia	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Elderly individuals; probable diagnosis of Alzheimer&apos;s disease; with aberrant motor behavior refractory to non-pharmacological measures	Use of implanted ferromagnetic devices; recent stroke; history of seizures; use of neuroleptics in the last 2 weeks; electrolyte disturbances; immobile; frail	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-4qfh2dk	Treatment of Depression using Light-based Brain Stimulation	Recruitment completed	Intervention	2026-01-28	<NULL>	<NULL>	8810	Photobiomodulation in Treatment-Resistant Depression	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-01	Faculdade de Ciências Médicas da Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Adults of both sexes; age between 18 and 65 years; diagnosis of major depressive disorder; failure to respond to at least two adequate antidepressant treatments; baseline Montgomery-Åsberg Depression Rating Scale score greater than or equal to twenty, indicating moderate depression	Diagnosis of bipolar disorder; presence of psychotic symptoms in the current depressive episode; pregnant or breastfeeding individuals; use of neuromodulation treatments within the past twelve months, including transcranial direct current stimulation, transcranial magnetic stimulation, or electroconvulsive therapy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-3hdzygd	How thoracic wall blocks affect heart surgery: a study assessing their effectiveness	Recruitment completed	Intervention	2026-01-28	<NULL>	<NULL>	8811	Chest Wall Blocks in Cardiac Surgery: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Instituto das pequenas missionárias da Maria Imaculada	<NULL>	<NULL>	<NULL>	Adult patients aged between 25 and 80 years ; both sexes ; elective cardiac surgery ; median sternotomy (valve replacement, valvuloplasty or myocardial revascularization)	Extracorporeal circulation (ECC) time: greater than 120 minutes ; perioperative complications: primarily surgical, which may directly impact the analyzed outcomes ; diseases with pain hypersensitivity: conditions that may significantly alter pain perception and opioid consumption (e.g., fibromyalgia, neurological diseases that impact pain sensitivity) ; reoperative surgeries: pain and recovery time may differ significantly ; coagulation disorders that may increase the risk of hematomas in regional blocks ; allergy or contraindication to local anesthetics or adjuvants; inability to communicate and assess: patients who cannot express or report their pain reliably (e.g., severe neurological disorders, cognitive impairment)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-7wvmyhx	Use of floral therapy to reduce pain and anxiety during intrauterine device insertion	Recruitment completed	Intervention	2026-01-27	<NULL>	<NULL>	8802	Use of Floral Therapy for Pain and Anxiety During Intrauterine Device Insertion: A Triple-Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-02	Universidade Federal da Paraíba (UFPB)	<NULL>	<NULL>	<NULL>	Women of reproductive age; clinical indication for intrauterine device insertion; attendance for elective intrauterine device insertion; ability to understand and sign the informed consent form.	Confirmed or suspected pregnancy; clinical contraindication to intrauterine device use; prior use of analgesics or anxiolytics immediately before the procedure; known allergy to components of the floral therapy or placebo; inability to understand study instructions.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-10c878rd	Using an electric current in the brain to rehabilitate a patient with speech difficulties	Data analysis completed	Intervention	2026-01-27	<NULL>	<NULL>	8803	Use of Transcranial Direct Current Stimulation in the rehabilitation of patients with Aphasia	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-01	Departamento de Fonoaudiologia - UFMG	<NULL>	<NULL>	<NULL>	Men and women; aged over 18. Native speakers of Brazilian Portuguese. Diagnosis of non-fluent aphasia resulting from a single episode of stroke in the left hemisphere. Premorbidly right-handed. Chronic phase of the lesion (&gt; 6 months). Performance below 70% in the task of oral naming of nouns and verbs	Previous diagnosis of communication, speech or language disorders prior to the current condition. Comorbidities involving the spinal cord. Psychiatric disorders. Uncontrolled seizures. Epilepsy. Increased intracranial pressure. Pregnancy. Use of a cochlear implant or implanted metallic material. Uncontrolled clinical comorbidities. Dependence on alcohol or chemical substances	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-5spk93j	Study on brain hyperactivity in children with autism	Recruiting	Intervention	2026-01-27	<NULL>	<NULL>	8804	Reduction of cerebral hyperactivity in autism spectrum disorder	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-30	Instituto de Ensino e Pesquisa Alberto Santos Dumont	<NULL>	<NULL>	<NULL>	Participants of both sexes; diagnosis of Autism Spectrum Disorder confirmed by a professional not affiliated with the research team; age between 3 and 12 years; availability of a finalized diagnostic report confirming Autism Spectrum Disorder prior to the beginning of the evaluations; written informed consent provided by parents or legal guardians	Absence of a confirmed Autism Spectrum Disorder diagnosis or diagnostic report; use of pacemakers or other electronic implants including cochlear implants; presence of metal implants or plates in the skull or body; history of epilepsy or seizures; neurological comorbidities such as brain tumors or intracranial infections; history of brain surgery; severe cardiac disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-98n8cw2	How technology can help women with polycystic ovaries exercise more	Recruiting	Intervention	2026-01-27	<NULL>	<NULL>	8805	Use of electronic tools to encourage physical activity in women with Polycystic Ovary Syndrome	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-17	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Women diagnosed with Polycystic Ovary Syndrome according to the Rotterdam Consensus criteria; aged between eighteen and forty years	Women with endocrine system abnormalities that may interfere with the hypothalamic pituitary axis; hyperprolactinemia; thyroid disorders; late-onset congenital adrenal hyperplasia; Cushing’s syndrome; presence of androgen producing ovarian or adrenal tumors; smokers; alcoholics; pregnant; breastfeeding women; those who do not adhere to the study protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-5y8k7d7	Cardiopulmonary rehabilitation with and without blood flow restriction during resistance training in heart failure	Recruiting	Intervention	2026-01-27	<NULL>	<NULL>	8806	Exercise-based rehabilitation program with versus without blood flow restriction in individuals with heart failure with reduced ejection fraction	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Católica de Brasília	<NULL>	<NULL>	<NULL>	Patients aged between 40 and 70 years; of both sexes; diagnosed with Heart Failure with Reduced Ejection Fraction (HFrEF) or Heart Failure with Preserved Ejection Fraction (HFpEF); classified as functional class II or III according to the New York Heart Association (NYHA); on stable optimized medical therapy; heart failure with ejection fraction equal to or less than 40%	Any relative or absolute contraindication to exercise; presence of pacemaker with fixed heart rate and heart rate limits below the target proposed for physical training; major cardiovascular events or procedures performed within two months prior to study inclusion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-10t2kxmq	Evaluation of herbal treatments for the control of menopausal symptoms	Not yet recruiting	Intervention	2026-01-27	<NULL>	<NULL>	8807	Evaluation of the effectiveness of Cimicifuga racemosa and Morus nigra L in the control of climacteric symptoms	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Universidade Federal de Alfenas	<NULL>	<NULL>	<NULL>	Women; aged 45 to 59 years; mentally able to provide their data; with permanent residence in the area covered by the municipality; who are seen in medical consultation during the period from March 02, 2026 to December 05, 2026; who agree to participate in the study and present inclusion characteristics in the study such as: hot flashes, vaginal dryness, anxiety, insomnia, weight gain	Smoking women; using conventional hormone replacement therapy; vegetarians; Asian women not registered by the team in the Medical Specialties Center Care System (CEM)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-9ychtdt	Efficacy of Therapeutic Education in Chronic Shoulder Pain	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8793	Effect of therapeutic education and patient-centered exercise approach on chronic shoulder pain a controlled clinincal trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal do Delta do Parnaíba	<NULL>	<NULL>	<NULL>	Volunteers; both genders; age ≥ 18 years; persistent shoulder pain with a predominantly nociplastic and/or nociceptive pain phenotype; diagnosis of subacromial  impingement syndrome/chronic subacromial pain; in the clinical evaluation, obtain 3 positive results out of 5 shoulder impingement tests, namely: Neer&apos;s sign, Hawkins and Kennedy test, empty can test, painful abduction arc, and external rotation resistance test	"limitation of ≥50% of the range of motion for passive internal or external rotation of the shoulder in ≥2 planes of motion; shoulder pain &gt;7/10 on the visual analog scale; pregnancy; cervicobrachialgia confirmed by Spurling Test; any warning signs detected in the initial history, indicating potential signs of tumor, infection, fracture or unreduced dislocation, neurological injury, non-stress-related pain in the shoulder region; history of upper limb fracture; systemic musculoskeletal disease; current or previously diagnosed carcinoma; shoulder surgery; glenohumeral instability; complete tear of any rotator cuff or biceps brachii muscle; acute traumatic shoulder pain; history of analgesic injections less than 3 months ago; cognitive disorders;
Involvement in other exercise-based therapies; more than 4 hours per week of overhead shoulder training activities"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-8g3q8q6	Healing of the roof of the mouth after surgery using an intraoral dressing, with or without tissue from the patient	Recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8794	Healing of the palatal wound protected with a self-adhesive intraoral dressing with or without autogenous epithelialized fragments: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-02	Universidade Federal de Pelotas	<NULL>	<NULL>	<NULL>	Age equal to or greater than eighteen years; Not having any reported systemic diseases, even if controlled; Having a healthy periodontium, defined as probing depth equal to or less than three millimeters, or presenting a stable periodontal condition after conventional periodontal therapy, defined as probing depth equal to or less than four millimeters without bleeding on probing; Having a gingival bleeding index lower than ten percent and a visible plaque index lower than fifteen percent; Having a clinical indication for periodontal plastic surgery with harvesting of an epithelial-connective tissue graft for the treatment of single gingival recessions with a minimum depth of three millimeters, classified as RT1 or RT2, around sound natural teeth located in the maxilla or mandible, except molars; Not having a previous history of palatal graft harvesting; Presenting a minimum palatal thickness between two point five and three millimeters at the donor site, compatible with connective tissue graft harvesting; Being available to attend all clinical visits and home records scheduled in the study.	Pregnancy or lactation; Reporting the use of medications that adversely affect periodontal tissues; Having inadequate endodontic treatment; Being a smoker or former smoker who quit smoking less than one year ago; Having tooth mobility at the surgical site; Having the need for orthodontic treatment prior to root coverage surgery; Being allergic to any of the preoperative or postoperative medications that will be prescribed, including dexamethasone four milligrams, amoxicillin five hundred milligrams, nimesulide one hundred milligrams, dipyrone five hundred milligrams, or chlorhexidine gluconate zero point twelve percent.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-596mnj6	Retrospective cohort study for the validation of a predictive index of successful Hemodialysis discontinuation in patients with Acute Kidney Injury based on clinical variables	Data analysis completed	Observational	2026-01-26	<NULL>	<NULL>	8795	Clinical variables predicting successful discontinuation of Renal Replacement Therapy in hospitalized patients with Acute Kidney Injury – a retrospective study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-01	Impar Serviços Hospitalares S/A	<NULL>	<NULL>	<NULL>	Patients with acute kidney injury requiring kidney replacement therapy	Pregnancy; kidney transplant; interruption of kidney replacement therapy due to hemodynamic instability, death or exclusive palliative care.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-2hrnx48	Online program to help adolescents reduce ultra-processed food consumption and protect kidney health	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8796	Online educational intervention to reduce the consumption of ultra-processed foods among adolescents: a pragmatic clinical trial focusing on the prevention of Chronic Kidney Disease.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-14	Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Adolescents aged 14 to 19; enrolled in a state public school in Nanuque, Minas Gerais; regular enrollment and attendance; Informed Consent Form signed by parents/guardians; Assent Form signed by the adolescent when applicable.	Cognitive or language impairments that prevent participation or completion of the instruments; transfer to another school during follow-up; refusal to take part in any study stage	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-2n6c247	Efficacy of Laser on therapy of Temporomandibular Disorders in individuals with Headaches	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8797	Efficacy of Low-Level Laser on therapy of Temporomandibular Disorders in individuals diagnosed with Primary Headaches	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Universidade Federal do Delta do Parnaíba	<NULL>	<NULL>	<NULL>	Individuals between the ages of 18 and 65, regardless of gender; Be Brazilian; Have a diagnosis of primary headache according to the third edition of the International Classification of Headache Disorders  Agree to answer all survey questionnaires and undergo the necessary treatments for the proposed duration	Individuals with a history of tumors and neuronal involvement; Diagnosis of Temporomandibular disorders concomitant with pain of odontogenic, neuropathic, and/or tumoral origin; Individuals diagnosed with non-painful Temporomandibular disorder; Pregnant women; Individuals with missing front teeth or dentures, making it impossible to measure maximum mouth opening by measuring the distance between the upper and lower incisors	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-10w4cvsv	Effect of Laser Therapy on pain and functionality of women after cesarean section	Recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8798	Effect of Photobiomodulation on pain and functionality of women after cesarean section a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-31	Faculdade de Ciências da Saúde do Trairi	<NULL>	<NULL>	<NULL>	Women who have undergone a cesarean section; aged between 18 and 40 years; in the first 12 hours after delivery of a single fetus; with or without a history of diabetes; and systemic arterial hypertension of previous origin or acquired during the gestational period; who agree to participate in the research, agreeing to sign the Free and Informed Consent Form (FICF)	Women who do not complete all assessments; those who present any complication such as hemorrhage; post-cesarean wound dehiscence; or sepsis; women with ineffective communication during the research period that compromises understanding and responses to assessments; presence of cancer or suspicion of cancer; skin hypersensitivity; use of photosensitizing medications, in case of epilepsy; and changes in sensitivity	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-4tzrdjz	Effects of combining different types of physical and cognitive Exercises on brain health in the elderly	Terminated	Intervention	2026-01-26	<NULL>	<NULL>	8799	Effects of different modalities of Dual Task Physical Exercise on the brain health of elderly people	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-04	Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Elderly individuals from local health units and the community; aged 60 years or older; of both sexes; capable of independent ambulation; with medical authorization to practice exercise; literate (able to read and write); able to understand verbal instructions for performing the tests; accessible to participate in training; and with a score &gt;17 on the Montreal Cognitive Assessment (MoCA)	Diagnosis of dementia; participation in a physical exercise program in the three months prior to the start of the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-6rbbkwm	Online self-care program for facial pain	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8800	Pain science education applied to the management of Temporomandibular Disorders: evaluation of a remote self-care program	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-30	Universidade Federal do Ceará	<NULL>	<NULL>	<NULL>	Individuals aged 18 years or older; of both sexes; diagnosed with chronic temporomandibular disorder according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD); pain intensity greater than or equal to 4 on the Numerical Rating Scale; pain duration of at least three months; access to the internet and an electronic device; ability to read and understand the educational material Facial Pain	Presence of systemic diseases or neurological disorders that may interfere with pain perception; current psychiatric disorders that prevent participation; pregnancy; ongoing treatment for temporomandibular disorder; inability to participate in online sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-6wshhsb	Treatment outcomes of Direct Restorations with Fibers in non-vital front teeth: randomized double-blind clinical trial	Not yet recruiting	Intervention	2026-01-26	<NULL>	<NULL>	8801	Clinical performance of Direct Fiber-Reinforced Restorations in non-vital anterior teeth: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Odontologia da Universidade Federal do Amazonas	<NULL>	<NULL>	<NULL>	Participants of both sexes, aged 18 years or older, in good general and oral health, presenting at least one endodontically treated anterior tooth considered satisfactory, with no clinical or radiographic evidence of periapical lesions; participants must require an extensive restoration of the eligible tooth and present an opposing tooth in functional occlusion	Participants presenting parafunctional habits, such as bruxism; pregnant or breastfeeding women; teeth with pathological mobility, internal or external root resorption, or root fractures; cases with dental morphological alterations, such as fluorosis, amelogenesis imperfecta, dentinogenesis imperfecta, or tetracycline staining, as well as the presence of non-carious cervical lesions; patients undergoing orthodontic treatment; those with an indication for periodontal treatment; or with systemic conditions that may interfere with the prognosis of the treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-3hyqb9r	Effects of Blood Flow Restriction Induced by a Non-Elastic Band on Repetition Volume and Perceptual Responses During Resistance Exercise: A Randomized Crossover Trial	Recruiting	Intervention	2026-01-23	<NULL>	<NULL>	8791	Analysis of Perceptual Responses and Repetition Performance During Low-Load Resistance Exercise With Practical Blood Flow Restriction: A Randomized, Controlled, Crossover Experimental Trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-06	Universidade Estadual da Paraíba	<NULL>	<NULL>	<NULL>	Males aged between 18 and 34 years were considered eligible if they met the following inclusion criteria: engagement in resistance training for at least six months on a continuous basis; resting blood pressure below 140/90 mmHg; absence of a history of cardiovascular or metabolic diseases; absence of osteomyoarticular injuries within the previous year	Participants using substances capable of affecting exercise performance or perceptual responses; inability to properly perform maximal strength tests (one repetition maximum).	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-3vzdfyz	Effectiveness of the mbrp ser online protocol in synchronous and asynchronous versions among university students	Not yet recruiting	Intervention	2026-01-23	<NULL>	<NULL>	8792	Effectiveness of the online synchronous and asynchronous versions of the MBRP Ser protocol among university students: randomized controlled trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Be enrolled in an undergraduate or graduate program or be employed at one of the partner universities;  have agreed to participate in the study	Have a diagnosis of bipolar disorder; schizophrenia; another severe mental disorder; or a moderate to high risk of suicide; present acute symptoms of depression or anxiety without professional follow-up; have cognitive or sensory or motor impairments that may interfere with participation in the study; have previously engaged in mindfulness meditation within an 8-week structured protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-6ktp6t9	Study on the power of orange oil on mental health	Recruitment completed	Intervention	2026-01-22	<NULL>	<NULL>	8788	Psychobiological study of essential oil from Citrus species (Rutaceae)	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal do Rio Grande do Sul (UFRGS)	<NULL>	<NULL>	<NULL>	Volunteers in good physical and psychological health; both genders; aged between 20 and 40 years	Volunteers outside the 20-40 age range; diabetics; with chronic degenerative diseases; using psychotropic medication, using melatonin supplements	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-9qm7bqr	effects of Rhodiola rosea supplementation on psychoaffective and physiological parameters during resistance training in young and older adults	Recruiting	Intervention	2026-01-22	<NULL>	<NULL>	8789	evaluation of the effects of acute rhodiola rosea supplementation on psychoaffective and physiological parameters associated with resistance training in young and older adults	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-14	Universidade Federal do Rio de Janeiro Campus Macaé	<NULL>	<NULL>	<NULL>	Adults aged between 18 and 45  years old for young adults and above 60 years old for older adults; individuals engaged in resistance training for at least six months prior to the first study visit; with or without a diagnosis of common mental disorders (anxiety and/or depression); of both sexes	Osteoarthritis and rheumatoid arthritis; human immunodeficiency virus (HIV) infection; musculoskeletal disorders that prevent physical exercise; hypertension (systolic blood pressure above 120 mmHg and/or diastolic blood pressure above 80 mmHg); cardiovascular diseases; pregnancy and lactation; use of anticonvulsants; use of central nervous system stimulants, such as methylphenidate (Ritalin®, Concerta®), lisdexamfetamine (Vyvanse®, Juvene®), bupropion hydrochloride (Wellbutrin XL®, Zetron XL®, Bup), lithium carbonate (Carbolithium®); smokers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-65684zv	Breathing Exercises for preventing Cognitive Deficits in children  with Sickle Cell Disease	Recruitment completed	Intervention	2026-01-22	<NULL>	<NULL>	8790	The protective role of Breathing Exercises in preventing Cognitive Deficits in children  with Sickle Cell Disease	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Núcleo de Pesquisa em Oncologia	<NULL>	<NULL>	<NULL>	Children of both sexes; with a confirmed diagnosis of Sickle Cell Disease - SCD through hemoglobin electrophoresis; aged between 6 years and 13 years 11 months and 29 days; who assent and whose legal representatives freely consent to participation after being fully informed about the project	Children with associated diseases that affect the lungs and may cause bias in the results, such as cystic fibrosis or systemic sclerosis; children and adolescents with severe neurological sequelae that make it impossible to perform the proposed exercises	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-5dfgch4	Study on the impact of Meditation on mothers of premature babies on the practice of breastfeeding upon hospital discharge	Recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8781	Impact of the implementation of Meditative Practice in mothers attending the milk bank, on the breastfeeding rate at hospital discharge of premature newborns: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-24	Pontifícia Universidade Católica do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Mothers of premature newborns admitted to the hospital.	Illicit drug use; use of medication incompatible with breastfeeding; lack of interest in breastfeeding; presence of severe disturbance of consciousness/behavior; not participating in another study; multiple births; newborn with metabolic disease; death.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-9cqvm3t	Effect of Laser Therapy on lower limb pain in people with Diabetes: a randomized clinical trial.	Not yet recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8782	Effect of Photobiomodulation on neuropathic pain in people with Diabetes: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-06	Faculdade de Enfermagem - Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Age between 18-65 years; diagnosis of diabetic peripheral neuropathy; ability to walk independently without equipment or devices.	Amputation of any part of the foot; ankle-brachial index &lt; 0.9.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-56mv4sf	Methadone compared to fentanyl in anesthesia for gallbladder removal surgery: a randomized, double-blind clinical trial	Recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8783	Single-dose intravenous methadone for anesthetic induction compared to fentanyl in laparoscopic cholecystectomy: a randomized, double-blind clinical trial	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Centro Uiversitário Una	<NULL>	<NULL>	<NULL>	Patients will be included if they: have signed an informed consent form; belong to American Society of Anesthesiologists (ASA) physical status I or II; have a surgical indication for laparoscopic cholecystectomy; have no chronic opioid use; have no severe psychiatric disorders or cognitive dysfunction; and have a body mass index (BMI) &lt; 35 kg/m²	Patients will be excluded if they have: a known allergy to fentanyl, methadone, or any other drug included in the study; belong to American Society of Anesthesiologists (ASA) physical status greater than or equal to III; are using tricyclic antidepressants or selective serotonin reuptake inhibitors (SSRIs); have severe liver or kidney disease; have a diagnosis of untreated cardiac arrhythmias or long QT syndrome; are under 18 years of age or over 65 years of age; have severe sleep apnea diagnosed by polysomnography.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-3hkxkc7	Effect of Probiotics on the Health Parameters of Cardiac Individuals	Not yet recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8784	Effect of Probiotic supplementation on inflammatory markers and cardiovascular risk, indicators of nutritional status, and clinical parameters in individuals undergoing Cardiac Surgery	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Faculdade de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Patients requiring revascularization; adults and elderly; of both sexes; undergoing surgical treatment for cardiovascular disease or following an acute coronary event. Eligibility will be confirmed through analysis of the participant&apos;s medical record and by questioning the participant	Individuals following unusual diets; those with food intolerances or allergies; and those using drugs or supplements that can directly alter the immune system, gut microbiota, and appetite, as these are confounding or effect-modifying factors in this type of intervention. Patients with morbid obesity; uncontrolled blood glucose or cholesterol levels. Probiotic intake for less than three months. Inability to comply with the study procedure. As a discontinuation criterion, participants who go for two consecutive days or more without consuming the supplement	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-10bg4v7f	Home blood pressure monitoring in individuals with difficult-to-control Hypertension: a randomized clinical trial	Data analysis completed	Intervention	2026-01-21	<NULL>	<NULL>	8785	Residential blood pressure monitoring in patients with uncontrolled Hypertension: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-12-12	Departamento de Enfermagem da Universidade Federal do Ceará	<NULL>	<NULL>	<NULL>	Patients diagnosed with hypertension associated or not with Diabetes Mellitus; Coronary Artery Disease or Chronic Renal Failure; aged over 18 years; diagnosis time greater than 6 months; blood pressure greater than or equal to 140/90 mm Hg obtained during initial clinical consultation; be following the same antihypertensive medication treatment for at least 4 weeks; present mobility conditions to attend follow-up appointments at the health unit	Pregnant women; women actively seeking to become pregnant; those with physical and/or cognitive disabilities; those who have undergone surgical procedures, suffered accidents and/or amputations; those undergoing oncological treatment that makes it impossible to self-monitor blood pressure; inability to maintain the monitor at home represented by the participant&apos;s refusal to receive and keep the device; acute cardiovascular event in the last three months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-5vc8wc2	Efficacy of adding non-invasive brain stimulation to Cognitive-Behavioral Therapy in the Treatment of Stress Symptoms Following Traumatic Experiences	Recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8786	Efficacy of Adding Non-Invasive Neuromodulation to Cognitive-Behavioral Therapy in the Treatment of Post-Traumatic Stress Symptoms	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Escola Bahiana de Medicina e Saúde Pública	<NULL>	<NULL>	<NULL>	Symptoms of Post-traumatic stress disorder (PTSD) for at least six months.	Individuals with self-reported associated disorders that may interfere with outcomes (such as panic disorder, generalized anxiety, craving, personality disorders or cognitive deficits, and suicidal ideation), participants who miss any treatment session, whether cognitive behavioral group therapy (gCBT) or vagal or magnetic stimulation, and individuals who experience adverse reactions to the treatments tested will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-4z9mt9h	Photobiomodulation and Vestibular Rehabilitation in women	Not yet recruiting	Intervention	2026-01-21	<NULL>	<NULL>	8787	Photobiomodulation Combined with Vestibular Rehabilitation in women with Unilateral Peripheral Hypofunction: a randomized, blinded clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Women; aged between thirty and forty years; bilateral hearing thresholds within normal limits according to pure tone and speech audiological assessment; speech language pathology diagnosis of unilateral peripheral vestibular hypofunction identified by the video head impulse test vHIT specifically characterized by alterations in vestibulo ocular gain at high head impulse frequencies; presence of intact middle ear and auditory pathways up to the brainstem confirmed by acoustic immittance measures and stapedial reflex testing; absence of a history of diseases related to neurological disorders and cognitive complaints that would prevent the performance of examinations or questionnaires	Presence of unilateral or bilateral hearing loss, regardless of type; presence of bilateral vestibulopathy; presence of central vestibulopathy; history of restricted ocular movement, including vergence disorders, strabismus, or high-degree refractive errors; alterations related to right ocular globe movement, right eyelid ptosis, as well as scars that impair detection of the right pupil; limitations in cervical mobility; presence of metabolic disorders or uncontrolled blood pressure; significant hormonal alterations, such as thyroid disorders, use of hormone replacement therapy, or use of contraceptives that may interfere with vestibular function or emotional state; clinical diagnosis of depression based on medical evaluation or prior report with use of antidepressant medication; functional or structural alterations of the middle ear identified through acoustic immittance assessment or otologic clinical examination	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-6bgkv44	Effects of weight training over a 16-week period on the aging of the immune system in older adults with Pre-Frailty.	Recruitment completed	Intervention	2026-01-20	<NULL>	<NULL>	8775	Effects of a 16-week strength training protocol on plasma levels of immunosenescence markers and myokines in longitudinally followed pre-frail older adults: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-07	Universidade Federal de Ouro Preto (Campus Morro do Cruzeiro)	<NULL>	<NULL>	<NULL>	Being female; age range between 60 and 70 years; untrained in strength training; identified as pre-frail; vaccinated against COVID-19; independent in traveling to the intervention location and without permanent or temporary disability to walk; presenting neurological and/or cognitive conditions that allow them to answer the questionnaire (perceived by the interviewer during the presentation of the research and invitation to participate); free from any musculoskeletal injury; who have not undergone surgery in the last 12 months and who are not in physiotherapy treatment.	Women who experienced physical or general health problems prior to or after the start of the intervention; severe flu, respiratory tract infection, muscle and/or joint pain that could limit the performance of the exercises; those who refused to donate biological material (blood); and those who voluntarily or did not appear at the collection sites on the scheduled day and time.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-4543s2j	The use of laser as a non-pharmacological treatment for trigeminal neuralgia	Recruiting	Intervention	2026-01-20	<NULL>	<NULL>	8776	Photobiomodulation as a non-pharmacological approach for trigeminal neuropathic pain: a triple-blind randomized clinical study	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-10	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Inclusion criteria: individuals aged 18 years or older; of both sexes; regardless of ethnicity or socioeconomic status; diagnosis of trigeminal neuralgia confirmed by a neurologist; and signing of the informed consent form	Exclusion criteria include: participants with an inconclusive diagnosis of trigeminal neuralgia or those without prior evaluation by a neurologist; individuals with a history of other facial neuropathies; those who have undergone laser therapy within the last 3 months; and individuals over 80 years old	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-24r2xy7	Use of an oral antioxidant for melasma lightening	Recruitment completed	Intervention	2026-01-20	<NULL>	<NULL>	8777	Efficacy of oral Pycnogenol as an antioxidant nutraceutical in the treatment of melasma	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Unic- Universidade de Cuiabá	<NULL>	<NULL>	<NULL>	Adults aged between 18 and 59 years; clinical diagnosis of facial melasma; no use of topical treatments or procedures for melasma in the previous six months; availability for follow-up throughout the study period; and agreement to participate through signed informed consent	Pregnant or breastfeeding women; use of oral contraceptives or hormone replacement therapy not compatible with the study protocol; use of anabolic agents; concomitant use of systemic antioxidants; use of medications associated with hyperpigmentation; and clinical conditions that, at the investigator’s discretion, could interfere with participant safety or study outcomes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-49bpdn8	Use of a bioactive gel to help prevent and control tooth decay	Recruiting	Intervention	2026-01-20	<NULL>	<NULL>	8778	Use of bioactive gel containing S-PRG filler particles in the prevention and control of dental caries: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-20	Programa de Pós Graduação em Odontologia da Universidade Federal do Paraná	<NULL>	<NULL>	<NULL>	Children of both sexes; aged 3 to 9 years; who attend the research sites; whose parents or legal guardians read and sign the informed consent form	Uncooperative patients who do not allow clinical examinations to be performed; participants whose parents or legal guardians do not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-42cms7j	Photobiomodulation for women with endometriosis	Recruiting	Intervention	2026-01-20	<NULL>	<NULL>	8779	Photobiomodulation in women with endometriosis and pelvic floor myofascial pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-02	Maternidade Escola Assis Chateaubriand	<NULL>	<NULL>	<NULL>	Women receiving care at the Pelvic Physiotherapy outpatient clinic of Assis Chateaubriand Maternity School; over 18 years of age; diagnosed with deep endometriosis by ultrasound with mapping; who have not undergone previous endometriosis surgery; women who, during the physical examination (one-finger palpation of the pelvic floor muscles), present any level of pain during the increase in digital pressure performed by intravaginal manual examination towards the muscle tissue, which will be performed by a single evaluator; women who do not have cognitive dysfunctions that affect the understanding of the proposed activities and application of the questionnaires, obtaining a cutoff point of 20 on the Mini-Mental State Examination	Women reporting signs and symptoms of urinary tract infection; history of cancer, pelvic radiotherapy, or brachytherapy; pregnant women or women trying to conceive; continuous use of analgesic, narcotic, and muscle relaxant medications; genital prolapse grade III and IV (according to the Pelvic Organ Prolapse Quantification System); patients using photosensitive medicationsons	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:17
RBR-4wcdqxw	Safety and Efficacy of Zygomatic and Pterygoid Implants in Comparison	Not yet recruiting	Intervention	2026-01-20	<NULL>	<NULL>	8780	Safety and Efficacy of Zygomatic and Pterygoid Implants: A Non-Inferiority Study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Patients with an indication for full maxillary rehabilitation; Patients aged 18 years or older, of both sexes; Patients with sufficient bone availability for the placement of two zygomatic implants, two pterygoid implants, and two conventional anterior implants	Patients with uncontrolled systemic diseases; Smokers who consume more than 10 cigarettes per day; Patients using medications that may impair bone healing, such as bisphosphonates and corticosteroids	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-10zvr56h	Efficacy of LED Light Therapy in the Treatment of Recurrent Vulvovaginal Candidiasis	Recruiting	Intervention	2026-01-19	<NULL>	<NULL>	8770	Treatment of Recurrent Vulvovaginal Candidiasis with Photodynamic Therapy using Light Emitting Diode (LED)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-12	Maternidade Escola Januário Cicco	<NULL>	<NULL>	<NULL>	Women over 18 years of age in reproductive age; heterosexual; sexually active; presenting clinical signs compatible with vulvovaginal candidiasis; with laboratory-confirmed diagnosis of recurrent vulvovaginal candidiasis characterized by the occurrence of more than three episodes of infection within a 12-month period	Pregnant or breastfeeding women; women with known hypersensitivity or allergy to methylene blue; presence of anatomical vaginal malformations; inability to understand or sign the Informed Consent Form; current or past diagnosis of genital neoplasia; history of photosensitivity or use of photosensitizing medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-5qkchbv	Acute Effect of Locomotion Training with Visual and Auditory Stimuli on kinematic parameters and locomotion confidence in individuals after Stroke: a randomized clinical trial	Recruiting	Intervention	2026-01-19	<NULL>	<NULL>	8771	Acute effect of biofeedback Gait Training on kinematic parameters and walking confidence in individuals after Stroke: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-10	Faculdade de Fisioterapia	<NULL>	<NULL>	<NULL>	Both genders; who suffered a stroke less than 6 months ago (acute); who present residual motor impairments in at least one lower limb; aged 18 years or older; ambulate independently without the need for assistive devices; achieve the minimum score on the six-item cognitive impairment test (6CIT-P) for cognitive function assessment (which varies according to education level); muscle tone in the affected lower limb with a score between 1 and 1+ on the Ashworth scale	Patients who do not demonstrate safety to walk on the treadmill even after 3 familiarization sessions; those who experience adverse events during the intervention such as severe pain, falls, excessive fatigue, or any hemodynamic instability that contraindicates the continuation of the protocol; participants should not have bilateral motor impairment, nor an associated diagnosis of other neurological diseases (such as Parkinson&apos;s disease or multiple sclerosis), nor severe hearing or visual impairments that hinder the reception of biofeedback stimuli; those currently using botulinum toxin in the lower limbs or with decompensated cardiovascular disorders; during follow-up, participation will be considered irregular if the volunteer attends less than 70% of the sessions scheduled in the protocol. In this situation, the participant will be removed from the study, as low attendance could compromise both the effectiveness of the treatment and the reliability of the results	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-2rfyjxx	Effectiveness of Additional Treatments for Periodontitis: Clinical Study	Recruiting	Intervention	2026-01-19	<NULL>	<NULL>	8772	Efficacy of Adjuvant Therapies in non-surgical and surgical Periodontal Treatment: a randomized, controlled, clinical study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-05	Hospital Odontológico da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	For proposals 1 and 2, participants in the first group must be between 18 and 70 years of age; be diagnosed with periodontitis stages II to IV (moderate to severe), grade A to C; with at least two non-adjacent interproximal sites presenting a probing depth greater than or equal to five millimeters; a clinical attachment level greater than or equal to three millimeters and bleeding on probing in all four quadrants; as well as a minimum of fifteen natural teeth. Participants in the second group must present a diagnosis of uncontrolled type 2 diabetes mellitus, with glycated hemoglobin levels greater than or equal to 7%. Participants in the third group must smoke ten or more cigarettes per day for at least three years. For proposal 3, participants must present maxillary and/or mandibular molars with bilateral grade II furcation involvement, located on the buccal, mesial, or distal surfaces of the maxilla or mandible; or the presence of an intrabony defect; a probing depth greater than or equal to five millimeters and a horizontal probing depth greater than or equal to three millimeters (for furcation lesions) after non-surgical periodontal therapy; intraoral periapical radiographs showing radiolucency between the roots for grade II furcation defects and at least three millimeters of evident bone loss on periapical radiographs for intrabony defects; with no endodontic involvement or with satisfactory endodontic treatment	Medical disorders that required antibiotic prophylaxis or that could influence the response to treatment; having received periodontal treatment in the last 6 months; having used medications that affect periodontal tissues in the last 6 months; smokers or ex-smokers for less than 12 months; pregnancy; extensive prosthetic rehabilitation; undergoing orthodontic treatment; carriers of blood diseases; alcoholism and use of illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-8zmr6wc	Men&apos;s education during high risk pregnancy: assessment of men&apos;s participation in labor and pregnant women&apos;s satisfaction	Recruitment completed	Intervention	2026-01-19	<NULL>	<NULL>	8773	Partner Psychoeducation in care during the high-risk pregnancy-puerperal cycle: a randomized clinical trial on men&apos;s participation in labor and parturient satisfaction	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-27	Hospital das Clinicas da Faculdade de medicina de Ribeirao Preto da Universidade de Sao Paulo	<NULL>	<NULL>	<NULL>	Women and men; undergo high-risk prenatal care at the outpatient clinics of the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto; complete the prenatal education course offered by the nurses of the obstetrics center of the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto; be 18 years of age or older; have a partner	Pregnant women undergoing high-risk prenatal care at the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto, who have discovered fetal malformation or stillbirth during periodic examinations	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-9v9nmg7	Remote exercise and telehealth to reduce persistent symptoms in breast cancer survivors	Recruiting	Intervention	2026-01-19	<NULL>	<NULL>	8774	Effects of a remote intervention of Physical Activities guided by the Competence App application and mediated by Telehealth on Cancer-Related Fatigue, Chronic Pain, and interoceptive awareness in breast cancer survivors: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Programa de Pós-Graduação em Neuropsiquiatria e Ciências do Comportamento Universidade Federal de Pernambuco Campus Recife - UFPE/RECIFE	<NULL>	<NULL>	<NULL>	Adult women diagnosed with breast cancer (stage I–III) will be included; surgically treated; having undergone chemotherapy, radiotherapy, or both; reporting symptoms of cancer-related fatigue and chronic pain; presenting a weekly volume of physical activity in the last three months &lt; 150 min/week at moderate intensity or &lt; 75 min/week at vigorous intensity; and having access to a mobile device with the Android operating system	Participants will be excluded if they show tumor progression to stage IV or recurrence of breast cancer; have undergone hormone replacement therapy at any time; present other conditions that contraindicate the practice of physical activity (e.g., cardiovascular, neurological, orthopedic, or metabolic conditions); and participate in other exercise programs during the study period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-4vdkhwv	Brain and tibial nerve stimulation to improve urinary symptoms in Parkinson’s disease	Not yet recruiting	Intervention	2026-01-17	<NULL>	<NULL>	8769	Transcranial and tibial nerve electrical stimulation on overactive bladder symptoms in Parkinson’s disease – a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Medical diagnosis of Parkinson’s disease. both genders. age greater than or equal to 18 years. use of antiparkinsonian medication at stable doses for at least four weeks prior to study inclusion. not undergoing any other treatment for overactive bladder during the study period, including pelvic floor physical therapy. presenting at least two symptoms of overactive bladder according to the definition by Haylen et al. characterized by urinary urgency with or without urinary incontinence, urinary frequency greater than seven voids per day and nocturia greater than one void per night. presenting a minimum score of 22.5 points on the Montreal Cognitive Assessment, translated and adapted version. agreement to participate in the study and signing of the informed consent form	History of bladder outlet obstruction. history of pelvic radiotherapy. active bladder carcinoma. history of peripheral nerve injury. active lower urinary tract infection. uncontrolled diabetes mellitus. pregnancy or immediate postpartum period less than six months. urinary incontinence exclusively due to stress. presence of a cardiac pacemaker or implantable defibrillator. presence of metallic implants. botulinum toxin application to the bladder and or pelvic muscles within the past year. history of seizures. current use of anticoagulant medications. current use of anticholinergic medications. other central or peripheral neurological disorders that may interfere with neuromuscular transmission	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-10ps9fwx	Use of hyaluronic acid and green tea-based gel and mouthwash after dental implant placement	Not yet recruiting	Intervention	2026-01-16	<NULL>	<NULL>	8767	Evaluation of the peri-implant healing using a mouthwash and gel based on hyaluronic acid and green tea	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Ages between 18 and 70; patients who requiring dental implants to replace one or more teeth	Patients who are heavy smokers (More than 20 cigarettes per day); patients with uncontrolled diabetes (glycated hemoglobin above 8%); patients who are pregnant or breastfeeding; who do not agree to return for follow-u; and who have used corticosteroids;  chemotherapy;  and immunomodulators in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-43p8yst	Association between pain and inflammation after orthodontic elastomeric separation treated with Low-Level Laser Therapy and Cold Atmospheric Plasma: a randomized clinical trial	Data analysis completed	Intervention	2026-01-16	<NULL>	<NULL>	8768	Evaluation of pain parameters in orthodontic treatment under Cold Atmospheric Plasma application compared to Low-Level Laser Therapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Centro Universitário da Fundação Herminio Ometto	<NULL>	<NULL>	<NULL>	Participants aged 18 to 25 years; in good general and oral health; with no previous orthodontic treatment; with no history of antibiotic, anti-inflammatory, or analgesic use in the month prior to or during the study; with complete permanent dentition; presenting malocclusions requiring orthodontic treatment; and with mesial and distal contact between the molars	Participants who report previous orthodontic treatment; who use a prosthesis or implant; who present any physical or intellectual condition that prevents subjective pain assessment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-4xzqtkv	Heart rate variability analysis in intensive care patients with infection using a smartphone	Recruiting	Observational	2026-01-15	<NULL>	<NULL>	8758	Heart Rate Variability analysis in critical care patients with and without Sepsis using a smartphone and Wearable device	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-11	Hospital de Clínicas da Universidade Federal do Paraná	<NULL>	<NULL>	<NULL>	Critical care patients with and without sepsis	Pragnancy; Withholding or withdrawing of support at the time of enrollment; Chest skin wounds; Heart rhythm other than sinus rhythm	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-2skzsv2	Periodontal health and response to non-surgical periodontal therapy in transgender individuals undergoing hormone therapy	Not yet recruiting	Observational	2026-01-15	<NULL>	<NULL>	8759	Periodontal status and response to non-surgical periodontal therapy in transgender individuals undergoing hormone therapy: clinical, microbiological, and immunological assessment	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-19	Faculdade de Odontologia - Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Participants eligible for inclusion will be individuals aged 18 to 60 years who identify as transgender men or transgender women. The case group will consist of participants undergoing hormone therapy, whereas the control group will include transgender individuals not receiving hormonal treatment. Groups will be age-matched within a ±3-year range. All participants must present a diagnosis of periodontitis in stages I, II, or III according to the criteria of Caton et al. (2018) and the 2021 American Academy of Periodontology classification, defined by clinical attachment loss affecting two or more non-adjacent interproximal sites or by clinical attachment loss of at least 3 mm on the buccal or lingual/palatal surfaces of at least two teeth. Only cases in which attachment loss is not attributable exclusively to traumatic gingival recession, cervical caries, distal attachment loss associated with third molar eruption, draining endodontic-periodontal lesions, or vertical root fractures will be considered eligible.	Participants will be excluded if they present loss of five or more teeth due to periodontitis, have used antibiotics within the previous six months, or have undergone non-surgical periodontal therapy during the same period. Individuals with systemic conditions that may influence periodontal disease progression or treatment response—such as diabetes or immunological disorders—will also be excluded, as well as those requiring antibiotic prophylaxis for routine dental procedures, those under prolonged use of anti-inflammatory medications, and pregnant individuals. Participants younger than 18 years of age or those who do not provide written informed consent will not be included.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-2fczbt2	Effects of Intensive Rehabilitation of upper limbs associated with Non-Invasive Neuromodulation in children with cerebral palsy	Recruiting	Intervention	2026-01-15	<NULL>	<NULL>	8760	Effects of Pediatric Constraint-Induced Movement Therapy associated with Transcranial Direct Current Stimulation in children with Cerebral Palsy: randomized, triple-blind, controlled study, with implementation and cost-effectiveness analysis	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-28	Universidade Cidade de São Paulo (UNICID)	<NULL>	<NULL>	<NULL>	Patients diagnosed with Cerebral Palsy – CP of the spastic hemiparesis type; aged between 7 and 16 years; cognitively able to respond to commands requested by the therapist; able to attend the Association for Assistance to Disabled Children – AACD Ibirapuera for 3 weeks, 3 hours/day, 5 days/week; be accompanied throughout the entire protocol by the same caregiver, who participates in the child’s/adolescent’s routine; from a motor standpoint, the patient must be able to perform active movement of the Affected Upper Limb (AUL) with at least 45 degrees of shoulder flexion and abduction, 20 degrees of elbow extension, 10 degrees of wrist extension, and movement of three fingers, including the thumb (grades 2 and 3 of the Active Range of Motion Scale of CIMT); patients classified by the Manual Ability Classification System – MACS at levels I or II; no history of seizure in the last 12 months (patients who previously presented seizures, even if before the established 12 months, will be carefully evaluated by the medical team responsible for performing the Electroencephalogram – EEG for clearance to carry out the protocol); it will also be necessary to sign and complete the Safety Questionnaire prior to the HotSpot mapping procedure by Transcranial Magnetic Stimulation – TMS, to verify that the patient does not have any contraindication to the application of the technique; both gender	Patients who present musculoskeletal deformities that reduce the range of motion of the affected upper limb – AUL in each of the joints (shoulder, elbow, wrist) by more than 10 degrees; who present extensive encephalic lesions or untreated hydrocephalus; who have received botulinum toxin injections in AUL muscles within the last 6 months or have undergone corrective orthopedic surgery of the AUL during this same period; who have metallic implants in the cranial vault region or who have shunt valves with a metallic component	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-6qvzppn	How the Consumption of Vitamin D–fortified Milk can influence the Physical Health and Emotional Well-being of young women	Not yet recruiting	Intervention	2026-01-15	<NULL>	<NULL>	8761	Effects of Consuming Vitamin D-enriched Semi-skimmed Milk on Nutritional and Inflammatory Biomarkers and Psychological Symptoms in young women	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Faculdade de Saúde Pública  da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Cisgender women aged 18 to 35; with a body mass index (BMI) between 18.5 and 29.9 kg/m2 (normal weight and overweight); available to participate in all phases of the study; with regular internet access and a mobile device to communicate with the research team during the study period; who do not have an active diagnosis of psychiatric disorders such as anxiety, depression, and stress, and who consume milk and dairy products daily.	Lactating women; pregnant women; or women in the menopausal period (perimenopause and post-menopause); smokers; those intolerant or allergic to milk and dairy products; those following vegan and/or strict vegetarian diets; those using controlled medications (antidepressants and/or anxiolytics) and supplementing with vitamin D, calcium, or any nutrient with a potential effect on the study outcome up to 3 months prior to the study; those with decompensated metabolic disorders (type II diabetes mellitus, hypertension, and metabolic syndrome); concomitant participation in another clinical trial, and those with an active diagnosis of psychiatric disorders such as anxiety, depression, and stress.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-2qpj7vq	Surgery and Survival in People Aged 80 Years and Older in Private Hospitals in Brazil	Not yet recruiting	Observational	2026-01-15	<NULL>	<NULL>	8762	Surgical Mortality in Very Elderly Patients: A Multicenter Retrospective Cohort Study in a Network of Private Hospitals in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-13	Rede D&apos;Or São Luiz S.A.	<NULL>	<NULL>	<NULL>	patients aged eighty years or older, both gender, at the time of the surgical procedure; patients undergoing elective urgent or emergency surgical procedures requiring hospital admission; patients treated at private hospitals of the Rede D Or network located in the state of São Paulo	age younger than eighty years at the time of surgery; same day hospital discharge after the surgical procedure; patients undergoing exclusively diagnostic procedures such as upper gastrointestinal endoscopy, colonoscopy, or coronary catheterization; electronic medical records with incomplete, inconsistent, or unavailable data	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-7v2k495	Cashew nut plant-based beverage and its effects on the health of climacteric women	Not yet recruiting	Intervention	2026-01-15	<NULL>	<NULL>	8763	Consumption of vegetable drink based on by-products of chestnut cashew (Anacardium occidentale L.) and health markers in women climaterium	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Departamento de Nutrição e Saúde da Universidade Fedral de Viçosa	<NULL>	<NULL>	<NULL>	Women; aged 40 to 60 years; Body Mass Index classification as overweight (greater than or equal to 25 kg/m²) and obese (30 kg/m²); elevated waist circumference (greater than or equal to 80 cm for women) and excess body fat (greater than 32% for women)	Women under 40 years of age; men; body mass index lower than 30 kg/m²; athletes; shift workers; individuals with physical and/or intellectual disabilities; individuals who have undergone bariatric surgery; have experienced weight instability (5% of their usual weight) over the past three months; individuals following vegan, vegetarian, or restrictive diets (for example, gluten-free or lactose-free diets); pregnant and lactating women; patients with type 1 diabetes mellitus; autoimmune or immunosuppressive diseases (human immunodeficiency virus infection, rheumatoid arthritis, lupus); hormonal disorders (hyperthyroidism or hypothyroidism, Cushing’s syndrome); digestive diseases or disorders (gastritis, peptic ulcer disease, esophagitis, dysphagia, or chewing difficulties); individuals with inflammatory bowel diseases (ulcerative colitis, Crohn’s disease, diverticulitis, celiac disease, irritable bowel syndrome); hepatic diseases (hepatic failure, hepatitis, cirrhosis), renal diseases (chronic kidney disease), pancreatitis, cardiovascular diseases (angina, acute myocardial infarction, congestive heart failure), eating disorders (anorexia nervosa, bulimia nervosa, binge eating disorder), or cancer; history of illicit drug use and/or alcohol consumption exceeding 14 units per week; use of hormone replacement therapy; use of products enriched with prebiotics or probiotics (at least three weeks prior to screening) and use of fiber supplements (psyllium, inulin) or intake of large amounts of fermented foods (greater than 400 g/day); aversion or allergy to nuts; infectious episode in the previous month; use of anti-inflammatory drugs, corticosteroids, antibiotics, or other medications that may affect appetite and energy metabolism; habitual nut consumption exceeding 30 g/day; alcohol consumption exceeding 21 units (168 g) per week; and use of vitamin, mineral, or omega-3 supplements	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-68jndr9	Clinical Protocol for the Use of Noninvasive Respiratory Support in Acute Hypoxemic Respiratory Failure	Recruitment completed	Observational	2026-01-15	<NULL>	<NULL>	8764	Development and implementation of an assistance protocol for the use of non-invasive support in patients with acute hypoxemic respiratory failure as a quality improvement tool	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-07-21	Instituto Nacional de Infectologia Evandro Chagas - INI/Fiocruz	<NULL>	<NULL>	<NULL>	Age ≥ 18 years; use of HFNC during hospitalization	Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-9gr68rb	Study on manual therapy and exercises for the treatment of tinnitus	Recruiting	Intervention	2026-01-15	<NULL>	<NULL>	8765	Efficay of manual therapy combined with therapeutic exercises on clinical and functional outcomes of tinnitus in patients with Somatosensory Tinnitus: a parallel randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Federal de Pernambuco	<NULL>	<NULL>	<NULL>	Individuals of both sexes; between 18 and 80 years; with somatosensory tinnitus according to the tinnitus diagnostic decision tree classification by Michiels et al. (2022); characterized by a simultaneous increase or decrease in tinnitus and neck/jaw pain; tension in the suboccipital muscles; somatic modulation and bruxism	Tinnitus resulting from otological pathologies; history of ear trauma or previous ear surgery; sensorineural hearing loss; sinusitis; history of psychiatric disorders; progressive middle ear pathologies; intracranial pathology; traumatic injury or previous surgery of the cervical spine orofacial region or temporomandibular joint; tumors; recent treatment of the temporomandibular joint or cervical region within the last 2 months; cognitive impairment assessed by the mini-mental state examination (MEEM) with a cutoff score of 19 for illiterate individuals	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-34yc557	Positive Psychology and Mindfulness-based psychological treatment for older adults with Anxiety and Depression	Recruitment completed	Intervention	2026-01-15	<NULL>	<NULL>	8766	Positive Psychology and Mindfulness in the treatment of Anxiety and Depression in the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Ass. Educacional De Ciencias Da Saude - Aecisa	<NULL>	<NULL>	<NULL>	Elderly individuals aged 60 years and older. Elderly individuals exhibiting depressive and/or anxious symptoms according to a standardized mental health assessment tool. Elderly individuals with a previously confirmed diagnosis of depression and/or anxiety by a mental health professional	Elderly individuals with significant cognitive impairments such as neurocognitive disorders. Elderly individuals with significant psychiatric conditions (personality disorders and psychotic disorders)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:05
RBR-9h45v9v	Treatment of Knee with Shockwave Therapy	Other	Intervention	2026-01-14	<NULL>	<NULL>	8751	Treatment of Knee Osteoarthritis with Shockwave Therapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-19	Universidade Católica de Brasília - UCB	<NULL>	<NULL>	<NULL>	Both sexes; aged between 60 and 79 years; diagnosed with KOA confirmed by radiographic evidence, according to Ahlbäck&apos;s radiological classification on X-ray; being able to understand the study and voluntarily agree to participate, being accompanied by family members and after comprehension is observed by the interviewer; having no restrictions regarding the use of TOCE	Previous treatment with TOCE or any other treatment for knee osteoarthritis in the last six months; active infection in the knee joint; having undergone viscosupplementation in the knee less than a year ago; meeting at least one of the following contraindications: use of a pacemaker; diagnosis of deep vein thrombosis (DVT); diagnosis of cancer at any stage; patient having a blood coagulation abnormality (coagulopathy), or taking any type of anticoagulant; primary malignant disease (tumors) in the treatment area; acute soft tissue or bone infection; systemic infections; epilepsy; corticosteroid infiltration at the application site in the last 6 weeks; patient at high risk from any type of anesthesia or analgesia if it eventually needs to be used	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-4m4pxq8	Comparison of tests performed before liver surgery or transplant with the results of the final definitive analysis	Recruitment completed	Intervention	2026-01-14	<NULL>	<NULL>	8752	Analysis of the correlation between data from pre-resection/liver transplant examinations and definitive diagnostic/histopathological findings in liver studies	<NULL>	n/a, non-randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2020-12-05	Hospital de Clínicas da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Anonymized data from the liver transplant group of the Department of Surgery at the State University of Campinas were obtained through compilation of information from medical records of patients followed in the focal liver lesion outpatient clinic between January 2010 and January 2021, including information from the records of patients who died, with benign and malignant lesions. Patients over 18 years of age. Patients who underwent liver resection/transplant surgery at the University Hospital of the State University of Campinas	Absence of histopathological results for focal lesions in patients. Loss to follow-up of the patient. Patient refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-262xftk	Effects of Systemic Photobiomodulation Therapy on Lipedema	Recruiting	Intervention	2026-01-14	<NULL>	<NULL>	8753	Therapeutic effects of Systemic Photobiomodulation in Lipedema	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Centro Universitário das Faculdades Associadas de ensino - FAE	<NULL>	<NULL>	<NULL>	Female volunteers; aged between 18 and 42 years; diagnosed with lipedema in the lower limbs; agree to participate and sign the informed consent form	Pregnant women; individuals with hemophilia, bleeding disorders, or skin tissue abnormalities; individuals with rheumatological pathologies; individuals with diabetes mellitus or decompensated systemic metabolic disorders; those belonging to other research groups in the same study area and/or undergoing treatment for the pathology with another methodology; individuals with cancerous alterations; refusal to sign the informed consent form; health disorders known to be related to the onset of menopause and/or perimenopause; endocrine disorders not related to sex hormones but which are not adequately controlled; those who have undergone cosmetic surgery in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-5mnpmzc	Effect of a virtual exercise program on the health of women who have undergone breast Cancer	Recruiting	Intervention	2026-01-14	<NULL>	<NULL>	8754	Effect of a multicomponent physical conditioning telehealth program and an app providing guidance on a more active lifestyle on health outcomes in women who have survived breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Escola de Educação Física e Esporte da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Female sex; having completed oncological treatment within the interval of six months to five years; having received clearance from the oncology hospital healthcare team to engage in physical activity and/or exercise; being aged 40 to 69 years; not presenting metastatic disease, severe lymphedema, or other uncontrolled chronic diseases or conditions; having access to a mobile phone or computer with a camera; having access to the internet; agreeing to participate in the intervention involving a three-month virtual multicomponent physical teleconditioning program	To withdraw from continued participation in this study; to report cancer recurrence or any adverse event that poses a risk to health	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-10qrnb94	The effect of ozone therapy in the treatment of tooth sensitivity	Recruitment completed	Intervention	2026-01-14	<NULL>	<NULL>	8755	Clinical performance of Ozone Therapy in the treatment of Dentin Hypersensitivity – Randomized, split-mouth, and a blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-20	Universidade Estadual do Oeste do Paraná	<NULL>	<NULL>	<NULL>	Age 18 to 60 years. Both sexes. Without systemic involvement. Non-smokers. Presence of at least 2 teeth with dentin hypersensitivity on the vestibular surface (at least 1 tooth in each hemiarch)	Dental elements covered by prosthetic work or endodontic treatment. Constant use or with a medical history marked by chronic use of analgesics, anti-inflammatories and psychotropic drugs. Use of orthodontic appliances. Use of desensitizing agents in the last three months. Restorative treatment on the element with sensitivity for less than one month. Abutment teeth of removable partial dentures. Any other painful pathology. Teeth with restorative material on the vestibular surface. Level of cognition that makes it impossible to answer the questionnaires applied. Presence of carious lesions. Pregnant or lactating women. Parafunctional habits. Reflux problems and/or acidic diet. Occlusal problems. Teeth with premature contacts. Teeth with non-carious cervical lesions (clinically noticeable abrasion, abfraction or erosion) and presence of visible sclerotic dentin will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-9d2ytd8	Realistic simulation as an aid in teaching and learning diagnostic reasoning in nursing for women&apos;s health	Recruiting	Intervention	2026-01-14	<NULL>	<NULL>	8756	Clinical simulation as a teaching-learning strategy for diagnostic reasoning in nursing in women&apos;s health	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central - UFRN	<NULL>	<NULL>	<NULL>	Students enrolled in the undergraduate Nursing program; with regular attendance in the women&apos;s health course; with 100% attendance in the experiment	Students who have failed the course and are therefore retaking it	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-2w6dxtx	How periodontal treatment can influence good cholesterol (HDL) in patients with type 2 diabetes	Not yet recruiting	Intervention	2026-01-14	<NULL>	<NULL>	8757	Effect of Periodontal Treatment on HDL in patients with type 2 Diabetes Mellitus and Periodontal Disease	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-15	Instituto de Ciência e Tecnologia de São José dos Campos	<NULL>	<NULL>	<NULL>	Type 2 diabetics with periodontitis: diagnosis of periodontitis stages III or IV, grades B or C; age over 35 years; both sexes; diagnosis of type 2 diabetes mellitus – DM2; glycated hemoglobin levels between 7% and 11%; clinical attachment loss greater than 3 mm in two non-adjacent teeth and greater than or equal to 5 mm in at least 30% of the teeth; presence of a minimum of 15 teeth; formal consent through the Free and Informed Consent Form – TCLE. Type 2 diabetics without periodontitis: biofilm-induced gingivitis, associated with local or systemic factors; age over 35 years; both sexes; diagnosis of DM2 for more than 5 years; glycated hemoglobin levels between 7% and 11%; presence of at least 15 teeth; signature of the TCLE. Normoglycemic patients with periodontitis: diagnosis of periodontitis stages III or IV, grades B or C; age over 35 years; both sexes; clinical attachment loss greater than 3 mm in two non-adjacent teeth and greater than or equal to 5 mm in at least 30% of the teeth; presence of a minimum of 15 teeth; formal consent through the TCLE	Cardiovascular diseases, cancer, autoimmune diseases, gastrointestinal diseases, skin diseases, arthritis, lupus; pregnant or lactating women; smokers; patients who have undergone periodontal treatment in the last 12 months; recent change (within the last 3 months) in glycemic index or medication; other systemic inflammatory diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-9bhczry	Evaluation of quinoa bioester efficacy in skin rejuvenation	Recruitment completed	Intervention	2026-01-13	<NULL>	<NULL>	8743	Molecular evaluation of the skin	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-12	Fundação Oswaldo Cruz	<NULL>	<NULL>	<NULL>	Female participants; aged between 20 and 80 years; skin phototypes I II or III according to Fitzpatrick classification; presence of intact skin on the forearm region; availability to attend in-person assessments; signed Informed Consent Form	History of hypersensitivity or allergy to formulation components; presence of dermatosis wounds or scars in the test area; use of topical or systemic medications that may interfere with the assessment such as corticosteroids and antihistamines in the last two weeks; pregnancy or breastfeeding; intense sun exposure or use of self-tanners on the forearm region during the study; aesthetic procedures performed on the forearm region in the last 30 days	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-3kwhcht	Evaluation of the Efficiency of a Bedside Mobility Scale in a Hospital Setting	Not yet recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8744	Evaluation of the effectiveness of implementing a bedside mobility scale in a hospital unit	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade de Passo Fundo	<NULL>	<NULL>	<NULL>	Hospitalized patients who were able to ambulate without mobility restrictions before admission	Patients with restricted mobility due to environmental barriers such as isolation rooms or the use of devices that impede mobility; hospitalized clinical patients awaiting elective surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-5zjkx4y	Strategies to relieve pain during childhood vaccination: a study on non-pharmacological methods for children aged 1 to 4.	Not yet recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8745	Effect of Buzzy®, Pikluc® and breastfeeding versus usual care on pain during vaccination in children aged 12 to 48 months: pilot randomized clinical trial protocol.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Estadual de Feira de Santana	<NULL>	<NULL>	<NULL>	Age 12 to 48 months and 29 days; both sexes; child awake; child accompanied by parents or legal guardian over 18 years old capable of consenting; not having received analgesics or sedatives in the 12 hours before entry into the research; indication for meningitis vaccine via intramuscular route at the time of inclusion; breastfeeding children and mother available to breastfeed before and during the procedure	Fever equal to or greater than 37.5°C on the day; cold hypersensitivity; Raynaud&apos;s disease; sickle cell anemia; vascular diseases; having undergone needle interventions on the same day; skin lesions or nodules at the application site; cognitive deficit or any psychiatric condition such as autism, depression or anxiety; severe neurological conditions that alter behavioral assessment such as epilepsy or cerebral palsy; history of severe adverse reactions to vaccines; withdrawal by the guardian	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-7y5vh9j	Insonation pulse: relationships between age, sex, fitness level, restriction fractions, and muscle tissue quality	Recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8746	Insonation pulse adjustments in blood flow restriction training: impacts of age, sex, fitness level, restriction fractions, and muscle tissue quality	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-20	Centro de Ciências da Saúde	<NULL>	<NULL>	<NULL>	For Group 1 (G1): both sexes; be between 18 and 30 years old; have no history of cardiorespiratory diseases; ankle-brachial index between 0.91 and 1.30; answer negatively to all items of the Physical Activity Readiness Questionnaire; be classified as unsatisfactory in the International Physical Activity Questionnaire; in the 1-repetition maximum test, present a relative value &lt; 1.2; have no musculoskeletal injuries that hinder the performance of elbow flexion and knee extension exercises. For Group 2 (G2): be between 18 and 30 years old; have no history of cardiorespiratory diseases; ankle-brachial index between 0.91 and 1.30; answer negatively to all items of the Physical Activity Readiness Questionnaire; be classified as physically active in the International Physical Activity Questionnaire; in the 1-repetition maximum test, present a relative value ≥ 1.2; have no musculoskeletal injuries that hinder the performance of elbow flexion and knee extension exercises.	Subjects who experience any injury during the experiment that prevents them from continuing the study; who drop out of the study; or who do not attend training sessions regularly will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-6qvh3sf	Implementation of the sepsis protocol: a quasi-experimental study	Data analysis completed	Intervention	2026-01-13	<NULL>	<NULL>	8747	Implementation of the sepsis care pathway: an interventional pilot study.	<NULL>	n/a, single-arm-study, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-27	Hospital Universitário Gaffree e Guinle/HUGG/UNIRIO	<NULL>	<NULL>	<NULL>	Multidisciplinary healthcare professionals working in the medical clinic, of both sexes; nursing undergraduate students enrolled in the internship program (9th and 10th semesters); nursing and medical residents linked to the university hospital, who carry out their activities under the supervision of their respective preceptors and are able to initiate the protocol under supervision; protocols of patients aged 18 years or older, of both sexes, hospitalized in the medical clinic wards	Professionals who were on leave or vacation during the data collection period; professionals who did not attend the training day; protocols of patients admitted to the medical clinic with a previous diagnosis of sepsis; protocols previously opened in another hospital sector prior to admission to the medical clinic	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-10y59z79	Comparison of two settings of the same Laser in the endoscopic treatment of Kidney Stones	Recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8748	Comparison of the efficacy of two energy and frequency settings of the Pulsed Thulium:YAG Laser in the treatment of Renal Calculi by Transureteroscopic Ureterorenolithotripsy: a prospective randomized study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFM/USP)	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; both sexes; renal calculi with volume between 1600 and 4000 mm³; candidates for lithotripsy by retrograde ureterorenolithotripsy; provision of written informed consent	Impossibility of performing retrograde ureteroscopy (e.g., prior urinary tract reconstruction); inability to introduce a ureteral access sheath; contraindications to surgery, such as untreated urinary tract infection; concomitant ureteral stone; uncontrolled comorbidities; refusal to provide informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-37w5thk	Mat Pilates practice and its effects on muscle strength, balance, and quality of life in sedentary elderly women	Recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8749	Effects of verbal versus multimodal commands in mat Pilates on muscle strength, balance, and quality of life in sedentary elderly women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-18	Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Women; 60 years of age or older; Sedentary; Have not had any contact with the Pilates Method in the last three months	Elderly women with cognitive impairment; Individuals with musculoskeletal disease (pathology or structural deformity related to the spine or upper or lower limbs), systemic disease (rheumatological, metabolic or inflammatory), hearing or sensory impairment; Individuals with labyrinthine pathology who undergo treatments and/or other physical activities that interfere with quality of life, muscle strength and balance	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-7g5dxr5	The effectiveness of continuous cuff pressure monitoring versus intracuff lidocaine or seal pressure method in preventing postoperative odynophagia in pelvic surgery a randomized clinical study	Not yet recruiting	Intervention	2026-01-13	<NULL>	<NULL>	8750	The effectiveness of continuous cuff pressure monitoring versus intracuff Lidocaine or seal pressure method in preventing Postoperative odynophagia in pelvic surgery a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-19	Rede D&apos;Or São Luiz S.A.	<NULL>	<NULL>	<NULL>	Adult patients aged 18 years or older; classified as physical status I or II according to the American Society of Anesthesiologists; Mallampati classification grades I to III, with grade III accepted only in the absence of other predictors of a difficult airway; scheduled for elective laparoscopic pelvic surgery; indication for general anaesthesia combined with spinal anaesthesia; requirement for planned orotracheal intubation; surgical positioning in the supine position with a mild Trendelenburg tilt; both sexes	Refusal to participate in the study; presence of sore throat in the preoperative period; active smoking; prior history of oral or nasal surgery; active upper respiratory tract infection; pregnancy; chronic obstructive pulmonary disease; known allergy to any of the medications used in the study; increased risk of aspiration or gastro-oesophageal reflux; requirement for nasogastric tube insertion intraoperatively; presence of clinically relevant cardiopulmonary, neuromuscular, renal, or hepatic disease; use of succinylcholine; requirement for rapid sequence induction; anticipated difficult airway defined as Mallampati classification grade IV; need for more than one orotracheal intubation attempt; patients with a prior history of laryngeal disease; previous tracheostomy; chronic users of opioids or illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:04
RBR-4xm5mvq	Intraoperative knee nerve block with medication to relieve postoperative pain after prosthesis replacement.	Recruitment completed	Intervention	2026-01-12	<NULL>	<NULL>	8731	Genicular nerve block during intraoperative total knee arthroplasty: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-22	São Paulo Secretaria de Saúde	<NULL>	<NULL>	<NULL>	patients over 18 years of age; diagnosed with primary gonarthrosis and disabling knee pain with a visual analog scale (vas) pain score of 7 or higher; unresponsive to conservative treatment and with a prior indication for total knee arthroplasty; able to use the pain assessment method and follow hospital discharge guidelines.	known allergy to the medications used in the protocol; cognitive impairment preventing the use of a smartphone and understanding the visual analog scale for pain (vas) and the informed consent form; history of previous surgeries on the affected knee; renal or hepatic insufficiency, coagulation disorders, sensory neuropathies, and prior regular use of opioids; loss to follow-up during the evaluation period.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-4v87t3q	Testosterone and sexual desire in postmenopausal women with testosterone gel	Other	Intervention	2026-01-12	<NULL>	<NULL>	8732	Testosterone Levels and Sexual Desire in Postmenopausal Women After Transdermal Testosterone Use	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-04-01	Programa de Pós Graduação em Tocoginecologia	<NULL>	<NULL>	<NULL>	Postmenopausal women aged 50 to 60 years; with 12 months of amenorrhea; a sexual partner; normal gynecological examinations within the past twelve months; and reduced sexual desire	Smokers; women with a history of chronic venous disease, cerebrovascular disease, cardiovascular disease, migraine with aura, hepatic diseases, elevated liver enzymes, malignant disease, or a partner with sexual dysfunction	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:06
RBR-2t798hh	Immediate Restoration After Bleaching and Retention Rate of Resin Restorations in Cervical Lesions	Recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8733	Does immediate restoration after bleaching affect retention rates of composite resin restorations in cervical lesions: a randomized, examiner-blind, noninferiority controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Estadual de Ponta Grossa (UEPG)	<NULL>	<NULL>	<NULL>	Good general health according to the American Society of Anesthesiologists physical status classification I or II; age 18 years or older; both sexes; satisfactory oral hygiene and absence of periodontal disease; presence of at least 20 teeth in functional occlusion; presence of at least six anterior teeth in the maxillary and mandibular arches free of caries, restorations, or previous endodontic treatment; canine shade A2 or darker according to the VITA Classical shade guide; presence of two non-carious cervical lesions with similar clinical characteristics regarding size, shape, dimensions, and color; non-retentive lesions with a depth greater than 0.5 mm involving enamel and dentin; lesions located on vital teeth up to the second premolar in either arch	Cavosurface margins involving more than 50% of the enamel; current use of fixed orthodontic appliances or presence of dental prostheses; severe tooth discoloration such as tetracycline staining, fluorosis, or non-vital teeth; unsatisfactory oral hygiene characterized by a Simplified Oral Hygiene Index greater than 3; moderate to severe or chronic periodontitis with probing depth greater than 4 mm, bleeding on probing, and clinical attachment loss greater than 3 mm in more than four teeth; severe bruxism associated with significant masticatory muscle pain, temporomandibular joint pain, or marked tooth wear; known history of allergy to resin-based materials, bleaching agents, or any substances used in the study; pregnant or lactating women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-8w2wr4y	Effect of Music on Pain Relief During Arterial Introducer Removal via Femoral Route	Not yet recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8734	Effect of music on pain relief during femoral arterial introducer withdrawal: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Departamento de Enfermagem da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Patients admitted to the hemodynamics unit of the Onofre Lopes University Hospital for cardiac catheterization or arteriography of the lower limbs; need for removal of an arterial introducer via the femoral approach; elective procedures; individuals aged 18 years or older	Dislike of music; patients who have undergone cardiac catheterization or arteriography of the lower limbs; presence of chronic pain; previous analgesia; individuals with any neurological and/or cognitive problem that compromises the understanding and use of the scale and data collection instruments; individuals with hearing impairment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-8kttvnm	Special care for people with Persistent Pain	Recruitment completed	Intervention	2026-01-12	<NULL>	<NULL>	8735	Program for the care of people with Chronic Pain	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-05	Escola Superior de Educação Física e Fisioterapia - Universidade Federal de Pelotas	<NULL>	<NULL>	<NULL>	Participants of both sexes; aged between 18 and 65 years; history of low back pain lasting at least three months; pain intensity of 3 or greater during movement in at least one of the following directions, flexion, extension, or rotation; access to the internet	Participants with a history of rheumatic disease, lumbar myelopathy, tumors, or central or peripheral neurological disorders; history of significant trauma, fracture, or surgery in the lumbar region; signs of nerve root compression such as marked muscle weakness affecting the lower limb, decreased or absent patellar or achilles reflexes, and reduced sensation in the lower limb dermatomes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-5pkbmw7	Effect of a green tea and hyaluronic acid-based gel and an adhesive dressing on the repair of gingival graft donor beds	Recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8736	Effect of a green tea and hyaluronic acid-based gel and an adhesive dressing on the repair of gingival graft donor beds. Randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Age between 18 and 60 years; Good oral hygiene (Plaque Index &lt; 20%); Systemic health; Probing depth less than 3 mm in the affected areas of the recipient site; Isolated or multiple gingival recession with interproximal tissue filling the entire interproximal space; Absence of keratinized mucosa associated with teeth or dental implants	Patients with periodontal disease; Patients with systemic diseases or conditions or who use medications that alter bone metabolism (except for compensated diabetics); Uncontrolled diabetics (glycated hemoglobin above 8%); Pregnant or breastfeeding women; Heavy smokers (more than 10 cigarettes per day); Patients who use illicit drugs; Presence of periapical lesions; Patients who have used corticosteroids, chemotherapeutic agents, and immunomodulators in the last 6 months; Patients who did not agree to return for follow-up	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-7t7gy3x	Effect of laser therapy in the treatment of inflammation around implants with or without the use of soft tissue grafts	Not yet recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8737	The effect of photobiomodulation in the treatment of patients with peri-implantitis, with or without the use of soft tissue grafts	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients with at least one implant diagnosed with peri-implantitis; The implant must present: radiographic bone loss &gt; 2mm; probing depth &gt; 5mm; bleeding and/or suppuration on probing; prosthesis with at least 6 months of function; absence of implant mobility; age ≥18 years	Patients with previous peri-implant treatment at the surgical site; ASA III patients (except diabetics); Heavy smokers (&gt;20 cigarettes/day); Uncontrolled diabetic patients (HbA1c &gt; 7% or fasting glucose &gt; 180 mg/dL); Use of antibiotics in the last 30 days; Use of medications that alter the inflammatory response or bone metabolism; Pregnant and breastfeeding women; Patients with hemoglobinopathies; Patients with other systemic alterations that may compromise healing	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-6vbtc24	Green Coffee Extract and glycemia	Recruitment completed	Intervention	2026-01-12	<NULL>	<NULL>	8738	Effect of green conilon coffee extract (Coffea canephora) on the glycemic response of healthy individuals and individuals with insulin resistance	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-07	Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	To be eligible, you must: be a person with a normal weight (BMI) between 18.5 and 24.9 kg/m2 who considers themselves healthy; or be an obese person with a BMI greater than 30.0 kg/m2; be a coffee consumer; not experience any side effects from consuming the beverage; be 18 years of age or older; and be of either sex	People living with diabetes; smokers; pregnant or breastfeeding women; people with intestinal diseases; cardiovascular diseases; hypothyroidism; hyperthyroidism; a history of alcohol and/or drug abuse/dependence; people using weight-loss or hypoglycemic medications, exogenous insulin, anti-inflammatory drugs, or antibiotics; or those using supplements containing caffeine	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-10kjk5cq	Effects of Beetroot Juice Supplementation on the Physical Performance of physical exercisers	Recruitment completed	Intervention	2026-01-12	<NULL>	<NULL>	8739	Effects of Beetroot Juice Supplementation on the Physical Performance of physically active subjects	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-15	Universidade Federal de Lavras	<NULL>	<NULL>	<NULL>	Be aged between 18 and 59 years; have accumulated experience with some form of resistance training or CrossFit for at least six months; perform a minimum of four training sessions per week.	"Have any physical problems during the study that prevent them from carrying out the physical tests (e.g. osteoarticular injuries); start consuming other ergogenic resources during the study that may influence physical performance, such as creatine, caffeine, beta alanine and sodium bicarbonate;
adopting specific dietary regimes during the study that may affect physical performance (e.g. weight loss diet, low carb diet, ketogenic diet, etc.); not completing all stages of the study for any reason."	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-3cq8336	Assisted, hybrid, intensive voice treatment for voice disorders related to aging	Recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8740	Assisted, hybrid, intensive voice treatment in elderly people with Presbyphonia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-06	Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Elderly women or men (aged 60 or older) who have been diagnosed with presbyphonia	Structural changes or laryngeal lesions unrelated to aging; diagnosis of head and neck cancer or neurological diseases; smoking or being smoke-free for less than five years; previous laryngeal surgery; previous speech therapy in the last two years	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-2sfhgyy	Benefits of Acupuncture for Sleep Bruxism in college students	Terminated	Intervention	2026-01-12	<NULL>	<NULL>	8741	Benefits of acupuncture on sleep bruxism in undergraduate students: prospective clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Faculdade de Odontologia do campos de Araçatuba - UNESP	<NULL>	<NULL>	<NULL>	The volunteers who participated in the research were of both sexes, over 18 years of age, suspected of having bruxism, regularly enrolled for at least 6 months in undergraduate courses of various kinds, from public and private institutions in the city of Araçatuba-SP, over 18 years of age, suspected of having bruxism, and who voluntarily agreed to participate in the research and were willing to receive acupuncture treatment	Exclusion criteria included students with psychiatric disorders and unstable, uncontrolled chronic diseases, those with a phobia of needles, those who had received acupuncture in the three months prior to the study, pregnant and breastfeeding students, students with valvular heart defects, bleeding disorders, those taking anticoagulants, those with any implanted electrical device (pacemaker, implantable cardioverter defibrillator, brain or spinal cord neurostimulator), those with infection or abscess located at any of the selected acupuncture points, those using non-steroidal anti-inflammatory drugs, paracetamol and opioid analgesics in the previous 5 days, steroidal drugs in the previous 30 days, and individuals suffering from acute oral pain such as pulpitis and dental fractures, and those who refused to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-5nqr3b6	Effects of short exercise sessions throughout the day on physical performance and the cardiovascular system of physically active university students	Recruiting	Intervention	2026-01-12	<NULL>	<NULL>	8742	Effects of Exercise snacks on biomotor capacities and the cardiovascular system in physically active university students	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-08	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Adults aged between 18 and 30 years; both sexes; physically active, classified as active according to the short version of the International Physical Activity Questionnaire (IPAQ); absence of cardiovascular diseases; absence of metabolic diseases; absence of musculoskeletal and/or osteoarticular conditions that may limit the performance of the proposed exercises; voluntary agreement to participate in the study through written informed consent.	Participants who do not complete all pre- and post-intervention assessments; attendance lower than 75% of the scheduled training sessions.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-6q3kyyk	Use of Adenosine to improve heart protection during cardiopulmonary bypass surgery: a clinical study	Not yet recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8723	Effect of Adenosine Addition on myocardial protection during extracorporeal circulation: a double-blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Hospital Nossa Senhora da Conceição	<NULL>	<NULL>	<NULL>	All patients undergoing elective surgery for simple valve replacement or myocardial revascularization with extracorporeal circulation at Hospital Nossa Senhora da Conceição, Porto Alegre, aged 18 years or older, in accordance with the Informed Consent Form.	The following cases will be excluded from the study: previous cardiac surgery; chronic renal failure (serum creatinine greater than 2.0 mg/dl); severe psychiatric illness; urgent or emergency situations; multiple surgeries.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-10q6wv5t	Effects of Hatha Yoga practice on respiratory strength, knowledge management, emotional health and daily physical performance of women 60+	Recruitment completed	Intervention	2026-01-09	<NULL>	<NULL>	8724	Effects of a Hatha Yoga program on respiratory function, cognition, mental health and functional performance of elderly women: randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-01	Elaine Cristina da Silva Brandão	<NULL>	<NULL>	<NULL>	Be between the ages of 60 and 85;Have no musculoskeletal impairment to practice;Have no prior history of thoracic surgery	Having been diagnosed with a recent cerebrovascular disease;Having been diagnosed with a disease of the head (head and neck cancer), eyes, or ears	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-5xs4wzx	Effects of two different nutritional strategies in adults with prolonged symptoms of Covid-19	Not yet recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8725	Effects of two different nutritional strategies in adults with prolonged symptoms of Covid - 19	<NULL>	n/a, n/a, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-26	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Adults who meet the established inclusion criteria will be recruited, including age between 40 and 59 years; presence of overweight or obesity according to the cutoff points established by the World Health Organization in 2005; signed informed consent form; availability to participate in multiprofessional interventions twice a week in the morning period for 12 weeks; and attendance at the initial project assessments	As exclusion criteria participation in sports activities outside the project; failure to achieve at least 75 percent attendance in the offered interventions; absence for more than two consecutive sessions in the program; failure to follow the proposed recommendations such as adherence to the diet; presence of orthopedic cardiovascular conditions or cognitive impairments that prevent the practice of physical exercise; following another type of non recommended restrictive diet; use of psychotropic medications or appetite suppressants; and occurrence of any accident that makes participation in the practical interventions impossible	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-4whfkqb	How does handgrip strength training combined with inspiratory exercise influence blood pressure, heart rate, and cardiac effort in adults with normal blood pressure?	Recruitment completed	Intervention	2026-01-09	<NULL>	<NULL>	8726	Evaluation of the effects of isometric resistance exercise and inspiratory muscle training on the hemodynamics of normotensive adult individuals	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-10	Escola Bahiana de Medicina e Saúde Pública	<NULL>	<NULL>	<NULL>	Healthy male volunteers; aged between 18 and 30 years; within ideal weight range; physically active or inactive.	History of cardiovascular or respiratory disease; smokers; high-risk classification for cardiovascular disease, with two or more risk factors, according to the guidelines for stress testing and its prescription from the American college of sports medicine; drug abuse; pre-existing musculoskeletal disorders or neurological, renal, hepatic, gastrointestinal, psychiatric, hematological or metabolic diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-77968p8	Twelve-month follow-up of Dental Restorations in people undergoing treatment for Head and Neck Cancer: a clinical study comparing two materials	Recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8727	12-month evaluation of Restorations with “Bioactive” Material in patients that underwent Head and Neck Cancer treatment: double-blind, controlled and randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-09	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Patients who have undergone treatment for head and neck cancer (radiotherapy); both genders; over 18 years of age; have at least two carious cervical lesions; oral health consistent with the Simplified Oral Hygiene Index.	Patients with orthodontic appliances; those allergic to resin-based materials; those who have not undergone radiotherapy for head and neck cancer treatment.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-5378vnx	Comparison of Shoulder Muscle Gain between two ways of performing the Exercise of Lifting the Arms Sideways while Holding Weights: standing and with the trunk inclined on a bench	Recruitment completed	Intervention	2026-01-09	<NULL>	<NULL>	8728	Lateral Shoulder Raise Exercise with Dumbbells and Muscle Hypertrophy in Deltoids: traditional execution vs. variation with inclined trunk on bench	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-13	Centro de Ciências da Saúde - Universidade Federal de Pernambuco	<NULL>	<NULL>	<NULL>	Healthy women; untrained or minimally active; aged between 18 and 35 years; no participation in resistance training within the last 12 months; non-users of anabolic steroids; non-users of substances that may influence the study outcomes such as creatine or beta-alanine; cessation of use at least 1 month prior to study initiation; no consumption of high doses of caffeine before training sessions; availability to train twice per week on previously agreed days; provision of written informed consent	Positive response to one or more items of the Physical Activity Readiness Questionnaire (PAR-Q); presence of pain or significant discomfort during the specific shoulder abduction test performed on the day of protocol application; attendance below 80% of training sessions; occurrence of injuries during the intervention period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-3gbsyc2	Effects of the Thoracoabdominal Rebalancing (TAR) Method in preterm infants	Not yet recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8729	Effects of the Thoracoabdominal Rebalancing (TAR) Method in preterm newborns: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Faculdade de Ciências da Saúde do Trairi - Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Preterm newborns of both sexes; with gestational age of less than 37 weeks; chronological age greater than 96 hours of life; receiving non-invasive ventilation (NIV), including Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (Bilevel); and with Silverman-Andersen Score (SAS) greater than 0	Newborns presenting hemodynamic instability (persistent alterations in heart rate or blood pressure above or below expected values or predefined alarm limits, and difficult-to-control arrhythmias); use of invasive mechanical ventilation (IMV); a clinical diagnosis of pneumothorax, pleural effusion, atelectasis, anemia, or structural and/or functional abnormalities of the chest wall, diaphragm, or upper airways; cardiovascular malformations; and diagnosed genetic syndromes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-10ds8j6z	How different types of exercise influence the health of blood vessels in people with high blood pressure	Recruiting	Intervention	2026-01-09	<NULL>	<NULL>	8730	Acute effects of different modalities of Physical Exercise on vascular function in Hypertensive individuals	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Hypertensive women using antihypertensive medication of any class; age between 60 and 75 years; regular physical exercise practice for at least twelve weeks; possession of a medical certificate authorizing physical exercise; absence of osteomuscular limitations that prevent the performance of the proposed exercises; not undergoing hormone replacement therapy; signing of the free and informed consent form	Participants who do not complete all assessments and sessions; participants who modify antihypertensive medication during the experimental protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:03
RBR-3qkmvyp	National survey of tuberculosis and other respiratory diseases in children and adolescents	Recruiting	Observational	2026-01-08	<NULL>	<NULL>	8714	Nationwide epidemiological study of tuberculosis and other respiratory pathogens among children and adolescents in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-02	Hospital Moinhos de Vento	<NULL>	<NULL>	<NULL>	In the Hospital-based study arm we include patients aged from 6 months to less than 15 years are eligible if admitted for less than 7 days, have a chest radiograph performed during the current admission, and present at least one of the following signs at enrollment: age-specific tachypnea (6 months to 1 year: 50 breaths per minute, 1 to 4 years: 40 breaths per minute; 5 to 14 years: 30 breaths per minute) or respiratory retractions and/or; lower respiratory signs of wheezing, crackling, or diminished breath sounds and/or; danger signs of severe pneumonia according to World Health Organization guidelines and/or; radiographic signs suggestive of intrathoracic TB (tracheal compression and/or displacement; soft tissue opacity suggestive of adenomegaly; alveolar opacity; nodular infiltrate suggestive of miliary TB; cavitation; calcification of the lung parenchyma; or pleural effusion. In the Outpatient-based study arm we include participants aged 6 months to 15 years at TB referral clinics are eligible if they have 1 of the following: persistent, unremitting cough for more than two weeks and/or; unexplained axillary temperature above 37.8 °C for more than one week and/or; persistent, unexplained lethargy and/or; decrease in playfulness/activity reported by the parent/caregiver and/or; weight loss/failure to thrive (weight loss is defined as &gt;5% reduction in weight compared with the highest weight recorded in the last three months, and failure to thrive is defined as clear deviation from a previous growth trajectory), and/or documented crossing percentile lines in the preceding 3 months, and/or weight-for-age z score of ≤ −2 in the absence of information on previous/recent growth trajectory, and/or weight-for-height z score of ≤ −2 in the absence of information on previous/recent growth trajectory and not responding to nutritional rehabilitation (or antiretroviral therapy if HIV infected).	In the Hospital-based study arm, exclusion criteria include: diagnosis of pleural TB without lung parenchymal involvement on radiology. When it is not possible to obtain samples for the detection of M. tuberculosis through Xpert MTB/RIF Ultra analysis and liquid culture. Participants will also be excluded if, at the time of inclusion, they present a clinical diagnosis of laryngotracheobronchitis, cystic fibrosis, bronchiolitis obliterans, and/or asthma in crisis without clinical signs suggestive of associated infection; treatment for active TB for more than 72 hours at the time of respiratory secretion collection; previous history of active TB treatment; presence of tracheostomy and use of non-invasive and mechanical ventilation; presence of conditions that prevent the respiratory secretion collection procedure; patients with a diagnosis of healthcare-associated infection. In the outpatient study arm, exclusion criteria will apply when it is not possible to obtain samples for the detection of M. tuberculosis by Xpert MTB/RIF Ultra analysis or liquid culture. Participants undergoing treatment for active TB for more than 72 hours at the time of respiratory secretion collection will also be excluded, as will those with a prior history of active TB treatment, those with a tracheostomy, and those with a known impediment to respiratory secretion collection.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-10xmz97f	Effects of Sustainable Acoustics in Physical Education Classes on Student Stress	Recruitment completed	Intervention	2026-01-08	<NULL>	<NULL>	8715	Sustainable acoustics in physical education classes: effects on physiological and perceptual stress responses in students	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-20	Programa de pós-graduação Stricto sensu em Educação Física da Universidade Católica de Brasília	<NULL>	<NULL>	<NULL>	Adolescents of both sexes, aged between 10 and 12 years (inclusive), clinically healthy, and regularly enrolled in the final years of elementary education at the time of the study	Adolescents who are unable to adequately respond to the questionnaires; who are participating in other intervention studies during the research period; who present with cardiopathies or other medical conditions that contraindicate the performance of physical effort; who have moderate to severe hearing impairments or active otological infections; who present diseases or infections that may interfere with saliva production or with the collection and analysis of salivary cortisol; as well as those using substances or medications that may compromise sensory perception or the physiological parameters evaluated, will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-3yh6vtq	The Effect of Music in Assessing Anxiety in Cancer Patients Undergoing Chemotherapy	Recruiting	Intervention	2026-01-08	<NULL>	<NULL>	8716	The Effect of Music on Anxiety in Cancer Patients Undergoing Chemotherapy: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; Be a patient diagnosed with gastrointestinal cancer who is undergoing chemotherapy up to the third session or who is also undergoing radiotherapy and neoadjuvant surgery; Be a patient with preserved hearing acuity (negative whisper test).	Patients using anxiolytic medication; Those who have difficulty understanding the questions; Patients who are unable to maintain a dialogue with the researcher.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-6zf66bj	Effect of bodyweight training on Frailty in seniors with High blood pressure	Recruitment completed	Intervention	2026-01-08	<NULL>	<NULL>	8717	Effect of Bodyweight Interval Training on Frailty Status in Hypertensive Elderly: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Age 60 years or older; Be of any gender; Be recruited from the cardiogeriatrics sector of the Dante Pazzanese Institute of Cardiology; Be classified as frail	Diagnosis of dementia; Presence of psychiatric disorders; Presence of mental disability; History of stroke with severe impairment; Presence of physical impairment that prevents mobility for performing the exercises	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-22csg9k	Preventing the transmission of HTLV-1 from mother to child with antiretroviral therapy	Not yet recruiting	Intervention	2026-01-08	<NULL>	<NULL>	8718	Preventing vertical transmission of HTLV-1 with Integrase inhibitors	<NULL>	2-3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Centro de Pesquisas Gonçalo Moniz - CPqGM/ FIOCRUZ/ BA	<NULL>	<NULL>	<NULL>	Pregnant women living with Human T-lymphotropic Virus type 1 (HTLV-1), with diagnosis confirmed by Western blot, line immunoassay, or real-time polymerase chain reaction (qPCR); who agree to and consent to the participation of their newborns; and who have availability to attend the project visits.	Gestational age of 37 weeks or more; coinfection with Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV); presence of conditions that may compromise, in the investigator’s opinion, the safety of Dolutegravir (DTG) use and/or adherence to the protocol; participation in another clinical trial involving the use of antiretroviral agents or an experimental medication against Human T-lymphotropic Virus type 1 (HTLV-1); use of concomitant medication, including one or more agents capable of inducing the enzyme uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) and reducing Dolutegravir (DTG) concentrations, such as rifampicin, phenytoin, phenobarbital, or carbamazepine; use of concomitant medication that are substrates of the organic cation transporter 2 (OCT2), including but not limited to dofetilide, pilsicainide, or fampridine (also known as dalfampridine); individuals with known hypersensitivity to Dolutegravir (DTG) or any of its excipients. Exclusion criteria for the use of Dolutegravir (DTG) in newborns: gestational age less than 37 weeks at birth; birth weight less than 2 kilograms; known blood incompatibilities that may result in hemolytic disease of the newborn; hemoglobin value less than 13.0 g/dL; platelet count less than 50,000 cells/mm³; decreased total leukocyte count (Grade 3); creatinine value greater than 1.3 times the upper limit of normal (ULN) for gestational age and postnatal age (Grade 2); aspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater than 2.5 times the upper limit of normal (Grade 2); any other current Grade 3 event described in the toxicity table of the Division of Acquired Immunodeficiency Syndrome (DAIDS); severe congenital abnormalities or severely ill neonates, at the discretion of the examining physician	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-8fgkqv6	Optimizing at-home dental bleaching time	Recruiting	Intervention	2026-01-08	<NULL>	<NULL>	8719	Optimization of dental bleaching time with 22% carbamide peroxide: a randomized, blinded clinical trial	<NULL>	4, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Tuiuti do Paraná	<NULL>	<NULL>	<NULL>	Minimum age of 18 years; both sexes; good general and oral health, without systemic diseases that could interfere with teeth whitening; absence of periodontal disease, gingival recession, or carious lesions in anterior teeth; upper canines with a Whitening Index for Dentistry - WID shade less than 20 equivalent to A2 or darker, according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany); absence of restorations in anterior teeth, ensuring an accurate analysis of the color change; availability to attend consultations and follow the experimental protocol	Prior history of teeth whitening; pre-existing dentin hypersensitivity, reported by the participant or identified during screening; continuous use of analgesic or anti-inflammatory medications that may interfere with the perception of tooth sensitivity; use of orthodontic appliances, dental prostheses, or restorations in anterior teeth, as they may influence the color assessment; previous endodontic treatment in anterior teeth, which may affect the response to whitening; presence of severe tooth discoloration, including severe fluorosis, teeth without pulp, or stains resulting from the use of tetracycline; visible cracks in the dental enamel that may compromise the response to whitening; pregnancy or lactation, due to a lack of studies on the safety of whitening in this population; smoking or bruxism, which may influence color stability and oral health	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-33j54zk	Effects of Periodontal Treatment on radiotherpay induced Oral Mucositis	Not yet recruiting	Intervention	2026-01-08	<NULL>	<NULL>	8720	Impacts of Basic Periodontal Treatment on  Radiation-induced Oral Mucositis.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade do Estado do Rio de Janeiro - UERJ	<NULL>	<NULL>	<NULL>	Head and neck cancer patients aged 18 years or older; patients diagnosed with periodontal health or periodontitis stages I, II, III, or IV; Patients who will undergo head and neck radiotherapy as part of the oncologic treatment plan for head and neck cancer	Patients under 18 years old; Patients who have received dental treatment within the six months preceding recruitment; Pacients who have previously undergone radiotherapy or chemotherapy; Patients who are currently using bone resorption inhibitors or immunosuppressive drugs	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-643vk9t	Aquatic training for type 2 diabetes	Recruiting	Intervention	2026-01-08	<NULL>	<NULL>	8721	Physical training in an aquatic environment for the control of type 2 diabetes	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-02	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 35 and 90 years; diagnosis of type 2 diabetes confirmed by laboratory tests or use of hypoglycemic drugs; presentation of a medical certificate authorizing physical exercise; participation in the Physical Training in Aquatic Environments Extension Project for the Control of Type 2 Diabetes	As exclusion criteria, participants cannot have uncontrolled hypertension; be without medical treatment for diabetes; or have clinical, joint, or muscle impairments that prevent them from exercising safely	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-107c6rvs	Evaluation of the effect of two anesthetic techniques on the quality of hearing examination in children.	Not yet recruiting	Observational	2026-01-08	<NULL>	<NULL>	8722	Comparison between intravenous and inhalation anesthesia for performing the BERA test in pediatric patients.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Hospital de Clínicas da Universidade Federal do Paraná	<NULL>	<NULL>	<NULL>	Pediatric patients under 18 years of age; medical indication for auditory brainstem response testing under sedation/anesthesia;  consent of guardians	Severe neurological diseases; known allergy to anesthetic agents. clinical instability; previous use of medications that may alter the test	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-857zyyw	Brain Stimulation with Light for Chronic Migraine	Data analysis completed	Intervention	2026-01-07	<NULL>	<NULL>	8704	Photobiomodulation by Transcranial Infrared Light Stimulation (FBM) in Chronic Common Migraine (CCM)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-23	Município Do Cabo de Santo Agostinho	<NULL>	<NULL>	<NULL>	Volunteers of both sexes aged between 18 and 90 years; with more than 15 migraine days per month; using migraine prophylaxis medication in the last three months	Patients under 18 years of age; pregnant women; epileptics; patients with sequelae of acute or subacute stroke; patients who abuse analgesic medications for headaches; patients with catamenial headache; patients with less than 15 days of pain per month	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-10wn3xcp	Evaluation of Physiotherapy Resources to Speed Up Muscle Recovery After Fatigue	Recruitment completed	Intervention	2026-01-07	<NULL>	<NULL>	8705	Assessment of Physiotherapy resources to accelerate post Fatigue Muscle Recovery	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-27	Fundação Universidade Federal do Pampa UNIPAMPA	<NULL>	<NULL>	<NULL>	Adults of both sexes; sedentary individuals or non-athlete physically active individuals; age between 18 and 40 years; absence of active or recent musculoskeletal injuries in the lower limbs; absence of neurological, cardiovascular or metabolic diseases; no use of muscle recovery resources; no use of analgesic, anti-inflammatory or muscle relaxant medications within 48 hours prior to the assessments; ability to perform the exercise-induced muscle damage induction protocol in the hamstring muscles; signing of the Informed Consent Form	Athletes; presence of active or recent musculoskeletal injuries in the lower limbs; diagnosis of neurological, cardiovascular or metabolic diseases that contraindicate the procedures; use of muscle recovery resources; use of analgesic, anti-inflammatory or muscle relaxant medications within 48 hours prior to the assessments; inability to perform the exercise-induced muscle damage induction protocol in the hamstring muscles	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-8vc895f	Effects of multimodal prehabilitation in gastrointestinal oncological surgeries	Recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8706	Impacts of in-person and hybrid models of Multimodal Prehabilitation in cancer patients undergoing gastrointestinal tract surgeries a pragmatic clinical trial	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Adult patients of both sexes; aged 18 years or older; indication for elective thoracoabdominal surgery for diagnosis or treatment of gastrointestinal tract neoplasms such as esophagectomy, gastrectomy, duodenopancreatectomy or colorectal procedure; acceptance to participate in the research by signing the Informed Consent Form	Significant cognitive deficits or dementia that prevent understanding of instructions as determined by clinical assessment or validated test; medical contraindication to physical activity; cardiopulmonary, musculoskeletal, or neurological conditions that preclude exercise, such as unstable angina, decompensated heart failure, high risk of falls, or active fractures; prescription of enteral or parenteral nutrition in the preoperative period; active substance use disorders that compromise adherence to the protocol; decompensated comorbidities such as diabetes mellitus, renal or hepatic insufficiency, and uncontrolled hypertension; severe functional limitations such as prolonged bed rest, continuous use of oxygen therapy, or mechanical assistance devices; lack of access to an internet-enabled device or severe limitations in digital literacy without family support; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-8n5ndqj	The effect of Cajuína consumption in untrained individuals	Data analysis completed	Intervention	2026-01-07	<NULL>	<NULL>	8707	The effects of Cajuína supplementation in individuals untrained subjects submitted to an Acute session of high intensity exercise: a randomized, double-blind follow-up of 72 hours	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-06	Universidade federal do ceará	<NULL>	<NULL>	<NULL>	Male individuals; age between 18 and 40 years; physically untrained; body mass between 60 and 100 kilograms; body mass index between 18.5 and 29.9 kilograms per square meter; absence of regular structured physical exercise in the last six months; Clinically healthy; no regular use of antioxidant supplements; no continuous use of medications; fit for intense physical exercise	Current smoking; regular consumption of alcoholic beverages; use of illicit drugs; prior diagnosis of cardiovascular metabolic neurologic musculoskeletal liver renal, hematological or respiratory diseases; history of food intolerance to the components of the intervention; use of drugs or supplements with potential antioxidant effect in the last three months; presence of musculoskeletal injuries that prevent intense physical exercise	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-3rq9tby	How to improve pre-surgical care in hospitals or remotely	Recruiting	Observational	2026-01-07	<NULL>	<NULL>	8708	Reconfiguring clinical assessment in the context of perioperative medicine: in-person and virtual care centering on the patient – ​​a prospective study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-18	Irmandade Santa Casa de Misericordia de Porto Alegre	<NULL>	<NULL>	<NULL>	Adult patients aged 18 or over; candidates for elective surgeries; physical status according to the American Society of Anesthesiologists as I or II; both genders; internet access for teleconsultation	Patients with physical status III or higher according to the American Society of Anesthesiologists; age under 18 years; pregnant women; presence of severe decompensated comorbidities; inability to communicate via the internet; refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-2v82f8c	How Brain Stimulation and Exercise can affect weight and mood in Obese women: a clinical study	Recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8709	Effects of Non-invasive Brain Stimulation combined with Aerobic Exercise on body composition and depressive symptoms in Obese adult women: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal da Paraíba	<NULL>	<NULL>	<NULL>	Adult women between 18 and 40 years of age, provided menopause has not yet begun; body mass index BMI, between 30 and 34.9 (grade 1 obesity); fat analysis profile by bioimpedance that falls above 28% and no eating disorder behavior in the last 6 months (e.g., bulimia and anorexia); no history of serious psychiatric comorbidities (e.g., schizophrenia, dementia); no use of appetite control medications, antidepressants, weight-loss medications, metabolic accelerators, or diuretics for at least 6 months; no surgery (e.g., bariatric surgery or liposuction) or weight-loss cosmetic procedures within the last 1 year; no metal implants located in the head, cochlear implants, or cardiac pacemakers; not pregnant or lactating; no history of seizures; healthy patients and/or without cardiac, vascular, or decompensated osteomyoarticular disorders that prevent aerobic exercise (e.g., kidney failure, diabetes mellitus); not having exercised regularly for 6 months	Participants who miss two consecutive sessions/assessments or who do not complete the experimental procedures; present any serious illness during the data collection, or choose not to continue in the research (withdrawal)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-9gqtzng	Assessment of vascular permeability with Point-of-Care ultrasound: an experimental study	Not yet recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8710	Assessment of peripheral venous catheter patency using Point-of-Care Ultrasound (POCUS)	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade do Estado do Rio de Janeiro - UERJ	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; of both sexes; using peripheral intravenous devices.	Patients with peripheral intravenous devices for surgical reasons, as it is not possible to assess adequate device patency. Patients with vasculitis, as they may present changes characteristic of the pathology, preventing adequate visualization of the venous network.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-7txk58d	Study for the evaluation of grafting in the surgical treatment of Peyronie&apos;s disease.	Not yet recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8711	Randomized comparative study to evaluate the clinical aspects of the Vivendi UR® aldehyde-free graft in the surgical treatment of Peyronie&apos;s disease.	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Fundação do ABC	<NULL>	<NULL>	<NULL>	Patients presenting with Peyronie&apos;s Disease in the chronic phase; with curvature greater than 60 degrees preferably uniplanar (patients with biplanar curvature will be accepted if secondary curvature is less than 20 degrees); without penile deformities with significant volume loss; patients must report adequate erectile function (erectile function questionnaire score greater than 22, reflecting adequate erection for vaginal penetration if penile curvature were absent); patients will undergo Penile Doppler Ultrasound with pharmacologically-induced erection to confirm normal penile hemodynamic status; heterosexual patient with sexual partner (patients with exclusive vaginal penetration); ability to complete questionnaires; able to read; be over 18 years old	Prior treatment for Peyronie&apos;s disease within the last three months; clinical contraindication for corrective surgery;  lack of rigidity for penetration; patients undergoing treatment for malignant diseases; patients who do not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-2r32rq6	Can Melatonin help you sleep better and protect your heart?	Recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8712	Melatonin intervention to improve the inflammatory profile and sleep of individuals with Cardiovascular Diseases	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Escola de Nutrição	<NULL>	<NULL>	<NULL>	Individuals undergoing treatment for cardiovascular disease; aged 19 to 60 years; of both sexes; with systemic arterial hypertension; dyslipidemias; diabetes mellitus; and high cardiovascular risk, determined according to the parameters of the Brazilian Guideline for the Prevention of Cardiovascular Disease in Patients with Diabetes (2017)	Use of anti-inflammatory drugs, immunosuppressants, or benzodiazepines; pregnant or breastfeeding women; presence of a diagnosis of renal insufficiency; thyroid disease; smokers; individuals undergoing hormone therapy; patients using antioxidant dietary supplements; significant dietary changes in the last 4 months; patients who present any of these criteria after the start of the intervention; and individuals who report digital illiteracy will not be included in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-6x33wsm	Functional Training for older people: functional aptitude, body composition, cognition and immunological parameters	Not yet recruiting	Intervention	2026-01-07	<NULL>	<NULL>	8713	Effects of functional training on functional status, body composition, cognitive function and immunosenescence of older people	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Universidade Federal de Sergipe - Campus Lagarto	<NULL>	<NULL>	<NULL>	Participants must be women aged 60 to 80; be physically independent; have no cardiovascular or musculoskeletal comorbidities, nor uncontrolled conditions that prevent physical exercise; not be undergoing hormone replacement therapy; and not have engaged in regular physical activity/exercise (two or more times per week) in the six months prior to the start of the study	After the interventions begin, participants who participate in additional regular physical exercise programs, consume ergogenic dietary supplements, miss four consecutive sessions, or do not achieve an attendance rate of 75% will be excluded from the protocol analysis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:02
RBR-4nxdrpq	How different aerobic exercise intensities impact sleep apnea and heart health	Recruiting	Intervention	2026-01-06	<NULL>	<NULL>	8696	Effect of different intensities of aerobic training on obstructive sleep apnea and cardiovascular variables	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-01	Escola Superior de Educação Física da Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Both male and female; aged between eighteen and sixty-five years; not meeting the minimum recommendations for physical activity in the last three months; no medical history of resistant Hypertension; Cerebrovascular Disease; Arrhythmias; presence of Pacemakers; Atrial Fibrillation; Heart Failure; Known Ischemic Cardiovascular Disease; Peripheral Arterial Occlusive Disease; Renal Failure; inability to exercise	Participants who do not complete at least 80% of the training sessions scheduled for the experimental group	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-4xbyr8g	Effect of Antioxidant gel on aesthetic Restorations performed after in-office Tooth Bleaching	Not yet recruiting	Intervention	2026-01-06	<NULL>	<NULL>	8697	Effect of Caesalpinia pyramidalis gel on aesthetic Restorations performed after in-office Tooth Bleaching: Eandomized clinical trial	<NULL>	3, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Programa de Pós-Graduação em Odontologia	<NULL>	<NULL>	<NULL>	Participants must be over 18 years of age; have good oral hygiene; not have periodontal disease; have at least two Class III restorations with vestibular access in the upper anterior teeth; not have undergone whitening treatment in the last 3 years; and have a right upper canine with a color of A2 or darker	Pregnant and breastfeeding women; volunteers with a history of allergies to dental products and who use orthodontic appliances. The selected teeth must not present caries lesions, pulpitis, endodontic treatment, dentin hypersensitivity, or absence of adjacent and antagonist teeth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-7zygtt6	Comparison of two strategies to adjust blood pressure medication in patients with severe infection and shock	Not yet recruiting	Intervention	2026-01-06	<NULL>	<NULL>	8698	Strategy of norepinephrine titration guided by peripheral perfusion versus conventional strategy guided by arterial pressure in patients with septic shock	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Fundação Universidade Caxias do Sul Hospital Geral	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; suspected or confirmed septic shock according to the Third International Consensus Definitions for Sepsis and Septic Shock; requirement for vasopressor therapy to maintain a mean arterial pressure of 65 millimeters of mercury or higher after adequate fluid resuscitation; serum lactate level of 2 millimoles per liter or higher; initiation of norepinephrine within the previous 12 hours; admission to the intensive care unit of Hospital Geral de Caxias do Sul; written informed consent provided by the participant or legal representative	Limitation of life sustaining treatment or do not resuscitate order; chronic dialysis or indication for renal replacement therapy within the next 8 hours; age younger than 18 years; hypotension not related to sepsis; traumatic brain injury; recent stroke; scleroderma; sickle cell disease; significant arrhythmias; pregnancy; refusal to participate in the study; severe peripheral vascular disease; hemorrhagic shock; cardiogenic shock; obstructive shock	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-7r6cf9r	Comparison of Polydioxanone and Polyglactin in midline aponeurosis incision closure after video-laparoscopic surgeries	Recruiting	Intervention	2026-01-06	<NULL>	<NULL>	8699	Comparison of midline aponeurosis incision closure with the use of Trocar of 10-12 mm using Polydioxanone and Polyglactin in video-laparoscopic surgeries: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Hospital Professor Edmundo Vasconcelos	<NULL>	<NULL>	<NULL>	Adults (&gt;18 years) undergoing elective or urgent video-laparoscopic cholecystectomy or inguinal hernia repair; BMI &lt; 35 kg/m²; Signed informed consent	Pre-existing/large umbilical hernias; converted surgeries; pregnant women; immunocompromised patients; collagenoses; local infection; contraindication to video-laparoscopy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-5zd29xp	Virtual reality games for studying the movements of neurodivergent people	Not yet recruiting	Observational	2026-01-06	<NULL>	<NULL>	8700	The interaction between neurodivergent individuals and virtual reality games as a means of identifying movement patterns	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Carlos Bandeira de Mello Monteiro	<NULL>	<NULL>	<NULL>	Children and neurodivergent adults with a prior diagnosis of at least one of the following conditions: Autism Spectrum Disorder; cerebral palsy; Down syndrome; intellectual developmental disorder; among others. Applicants of both sexes and without age restrictions; must have sufficient motor and cognitive skills to interact with virtual reality games; have stable medical conditions; and possess a level of verbal or non-verbal communication that allows for comprehension of the game&apos;s task	Participants unable to understand and execute the specific instructions and commands of the intervention; failure to adapt to the proposed intervention protocol; visual impairments; severe hearing impairments that prevent interaction with virtual reality games	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-6nq34m9	Result of an intervention to increase the assessment of child development using the Child Health Handbook in the municipalities Louveira and Jundiaí, São Paulo, Brazil	Recruitment completed	Intervention	2026-01-06	<NULL>	<NULL>	8701	Evaluation of an intervention aimed at the use of the Child Health Handbook for monitoring child development in the municipalities of Louveira and Jundiaí	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-12-16	Instituto de Saúde da Secretaria de Estado da Saúde de São Paulo	<NULL>	<NULL>	<NULL>	Children aged 0 to 3 years; both sexes; residents of the municipalities of Louveira or Jundiaí; attending the Basic Health Unit (BHU) for health follow-up; having had a consultation or home visit with a health professional from their reference Basic Health Unit (BHU) in the last three months. The intervention will be applied exclusively to Primary Health Care professionals, not to the children.	There will be no exclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-84bk587	Effect of Cookies containing Cashew Nut and Babaçu Flours on the overweight of adolescents	Recruitment completed	Intervention	2026-01-06	<NULL>	<NULL>	8702	Evaluation of the effects of the consumption of Cookies containing Mesocarp Flour of Babaçu on the Glycemic Profile of overweight adolescents: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-08	Centro de Ciências de Imperatriz	<NULL>	<NULL>	<NULL>	Overweight adolescents, with a body mass index (BMI) equivalent to percentiles between 85 and 97 or between +1 and +2 z score (overweight); percentiles between 97 and 99.9 or +2 and +3 z score (obesity) and percentile above 99.9 or +3 z score (severe obesity); age between 17 and 19 years	Adolescents with a history of allergy to babassu or cashew nuts and/or any component that will be used in the formulation of the cookies; and those who have started some nutritional intervention to reduce excess weight	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-25v5wjf	Effects of Andiroba Extract Oil on the Gingival Inflammaton	Recruitment completed	Intervention	2026-01-06	<NULL>	<NULL>	8703	Effect of Carapa guianensis Extract Gel on Dental Plaque (periodontopathogenic microorganisms) and Gingival Inflammation in patients undergoing fixed orthodontic treatment: a prospective split-mouth study	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Federal do Pará	<NULL>	<NULL>	<NULL>	Age between 12 and 17 years; both sexes; Must sign the research information letter and Informed Consent Form; must not have systemic alterations; normal cognitive and motor development; index teeth present: 13, 14, 15, 23, 24 and 25; must have class I malocclusion: crowding of anterior teeth, no crossbites and with coronal exposure for bonding of braces	Antibiotic treatment within 1 month prior to the evaluation; use of any medications that may affect gingival tissue; systemic diseases or conditions that may interfere with the study results (immunodeficiency, uncontrolled diabetes, hematological diseases, genetic conditions, deficiencies); presence of orthopedic orthodontic appliances and/or space maintainers; mucosal diseases; severe oropharyngeal infections; extensive caries in any tooth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-6vtvdgy	Retrospective observational study of restorations supported by implants produced using 3D-printing technology	Data analysis completed	Observational	2026-01-05	<NULL>	<NULL>	8689	Retrospective observational study of implant-supported restorations using additively manufactured dental implants	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-03-13	Universidade de Guarulhos	<NULL>	<NULL>	<NULL>	Titanium implants manufactured by additive manufacturing (AM) by Plenum Bioengineering will be included in the study.	No exclusion criteria were applied for this study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-627wc4w	Effect of injections in the treatment of Tennis Elbow	Recruitment completed	Intervention	2026-01-05	<NULL>	<NULL>	8690	Relative efficacy of peritendinous injections for the treatment of lateral epicondylitis of the elbow - a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-10	Universidade de Taubate	<NULL>	<NULL>	<NULL>	Patients diagnosed with lateral epicondylitis of the elbow; painful clinical presentation on the lateral aspect of the elbow and magnetic resonance imaging showing partial insertion tear of the extensors less than 50%; age over 18 years; both genders.	Patients with complete or partial tears greater than 50% of the extensor muscles or partial tears secondary to previous trauma or fracture; patients who have undergone previous surgery on the affected elbow or who have undergone previous elbow infiltration in the last 6 months; patients with other associated causes of painful elbow pathology such as osteoarthritis, loose bodies in the joint, joint stiffness; concomitant neck pain or other arm pain, symptoms suggestive of radicular neurological conditions; patients with active infections; pregnant women; and patients using immunosuppressants or chronic corticosteroid therapy.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-5wk24cp	Impact on wound healing after third molar extraction using a mouthwash containing green tea and hyaluronic acid or 0.12% chlorhexidine	Not yet recruiting	Intervention	2026-01-05	<NULL>	<NULL>	8691	Impact on wound healing after third molar extraction using a mouthwash containing green tea and hyaluronic acid or 0.12% chlorhexidine. Randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Patients must be over 18 years of age; Patients must have good oral hygiene (plaque index &lt; 20%); Patients must have all four third molars and be indicated for extraction of all third molars	Patients with periodontal disease; Patients with systemic diseases or conditions or who use medications that alter bone metabolism (except diabetics); Uncontrolled diabetics (glycated hemoglobin above 8%); Pregnant or breastfeeding women; Heavy smokers (more than 10 cigarettes daily); Presence of periapical lesions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10crngzr	Chiari malformation type I treatment: comparison between Resection of Filum Terminale  and Posterior Fossa Decompression	Recruiting	Intervention	2026-01-05	<NULL>	<NULL>	8692	Evaluation of patient-reported outcome in the treatment of Chiari Malformation type I in adults without tethered cord with Resection of the Filum Terminale versus Posterior Fossa Decompression: randomized non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-01	Hospital Universitário Onofre Lopes	<NULL>	<NULL>	<NULL>	age over 18 on the day of recruitment; have a radiological diagnosis of Chiari type I without tethered cord and clinical symptoms resulting from Chiari; free informed consent to participate in the study	Exclusion criteria will be: being under 18 years of age, failure to agree to a free and informed consent form, presence of radiological signs of tethered spinal cord, and diagnosis of psychiatric illness without regular treatment, since pre- and post-operative evaluations will include subjective complaints. Presence of symptoms or radiological signs of tethered spinal cord; diagnosis of psychiatric illness without regular treatment, since pre- and post-operative evaluations will include subjective complaints; previous neurological or spinal surgeries.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-4whyfr4	Analysis and relationship of tooth wear with possible causes in patients with jaw joint problems	Recruitment completed	Observational	2026-01-05	<NULL>	<NULL>	8693	Characterization and correlation of dental wear with possible etiological factors in patients diagnosed with Temporomandibular disorders	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-15	Faculdade de Odontologia da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	The patient must be undergoing treatment in the Orofacial Pain and Temporomandibular Disorder course at Fundecto (FOUSP); be at least 18 years old; either sex	History of oncological treatment in the orofacial region; current use of orthodontic appliances; presence of active caries or symptomatic endodontic treatment; grade 3 tooth mobility; uncontrolled periodontal disease; motor or neurological disorders; significant cognitive or intellectual impairments; wearers of complete dentures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-4244wxy	Effects of therapeutic treatment using tactile stimulation and joint movement, and skin-to-skin contact on the motor behavior of premature newborns: a non-inferiority randomized controlled clinical trial protocol.	Not yet recruiting	Intervention	2026-01-05	<NULL>	<NULL>	8694	Effect of Tactile-Kinesthetic Stimulation and the Kangaroo Method on the motor behavior of premature newborns: a non-inferiority randomized controlled clinical trial protocol	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-15	Empresa Brasileira de Serviços Hospitalares - EBSERH	<NULL>	<NULL>	<NULL>	Preterm newborns admitted to the Neonatal Intensive Care Unit of the Hospital da Mulher Mãe Luzia will be included in the study provided they are born with a gestational age between 28 and 36 weeks; with a corrected gestational age of 32 weeks or more; with an Apgar score greater than 6 at 1 and 5 minutes; of both sexes; older than 72 hours; with a body weight above 1.100g; presenting hemodynamic and clinical stability; receiving full enteral nutrition; via nasogastric or orogastric tube; or breastfeeding; in an incubator or crib; breathing room air or receiving support such as non invasive ventilation and oxygen supplementation	Preterm newborns will be excluded from the study if they present with congenital malformations; genetic syndromes; worsening of the underlying disease; hemodynamic and clinical instability; hypothermia; use of sedatives; thrombocytopenia with a value lower than 50.000; active hemorrhage; peri intraventricular hemorrhage; are on invasive mechanical ventilation; have a positive C Reactive Protein test; are in contact isolation or have experienced a cardiorespiratory arrest in the last 24 hours	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-8ypr4kj	Acute neuromuscular fatigue responses to russian current in paralympic powerlifting athletes	Data analysis completed	Intervention	2026-01-05	<NULL>	<NULL>	8695	Analysis of training based on biochemical, hormonal, immunological, blood, hemodynamic, muscle architecture, and neuromuscular indicators in Paralympic powerlifting	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Departamento de Educação Física da Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Minimum of 18 months of experience in the sport; participation in at least one official competition of the Brazilian Paralympic Committee; ranking among the top 10 in their respective body weight categories	Volunteer with pain and/or injury; intolerance to electrostimulation; use of analgesics, tranquilizers, antidepressants or any centrally acting medication	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:01
RBR-4ncxc27	Comparative evaluation of different digital impression techniques for full-arch implant-supported fixed dental prostheses	Recruiting	Intervention	2026-01-02	<NULL>	<NULL>	8687	Comparative evaluation of photogrammetry, intraoral scanning and accuracy of conventional limpression for implant-supported fixed dental prostheses of the complete arch	<NULL>	n/a, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-30	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Patients who are completely edentulous in the upper or lower arch; systemically healthy patients; patients with good cognition; aged between 18 and 60 years	Unavailability of bone tissue to allow implant placement; smokers; pregnant or breastfeeding women; patients with general contraindications for undergoing surgical procedures; chronic users of medications that affect bone metabolism	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-57zy3fd	Immediate impact of weight lifting on the muscles of the intimate region of adult women	Recruitment completed	Intervention	2026-01-02	<NULL>	<NULL>	8688	Immediate effect of a Weight Lifting Protocol on pelvic floor muscle function in adult women who perform Strength Training	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-07	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Nulliparous women aged 18 to 35 years; who perform strength training at least twice a week; and for a minimum of 3 months	Women who are allergic to latex; who have signs and symptoms of lower urinary tract infection in the last 4 weeks; who have undergone previous treatment for pelvic floor dysfunction; and women who have undergone previous gynecological surgery will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-7782d5x	Nutritional profile and eating problems in children with autism spectrum disorder	Recruitment completed	Intervention	2025-12-29	<NULL>	<NULL>	8685	Nutritional profile and eating behavior in children with autism spectrum disorder: before and after educational program	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Children aged 3 to 9 years; both sexes; clinical diagnosis of Autism Spectrum Disorder; parents/caregivers of the children	Children requiring specialized diets; for example cystic fibrosis; diabetes; cerebral palsy; those receiving enteral feeding; and those participating in behavioral feeding interventions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-63pbcy3	Oral minoxidil combined with Baricitinib or Baricitinib in the treatment of Alopecia Areata: a clinical trial to determine which is most effective	Recruiting	Intervention	2025-12-29	<NULL>	<NULL>	8686	Oral minoxidil combined with baricitinib versus baricitinib in the treatment of alopecia areata: a randomized double-blind clinical trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-21	Empresa Brasileira de Serviços Hospitalares - EBSERH	<NULL>	<NULL>	<NULL>	Patients of both sexes. Minimum age of 12 years. Patients with alopecia areata with a Severity of Alopecia Areata Tool - SALT score greater than or equal to 20 and a current episode lasting at least 6 months to a maximum of 10 years. Who have informed and agreed to participate in the study, or whose legal guardians agree to participate, during treatment at the trichoses outpatient clinic of the Dermatology Service of the Federal University of Goiás -UFG or in the private practice of the principal investigator. Patients who have previously received topical corticosteroids must be off the medication for one week. Users of oral and/or intralesional corticosteroids must be off the medication for at least two months. Patients who have previously used methotrexate or Janus kinase - JAK inhibitors must be off the medication for at least eight weeks to participate in the study	Patients with hypersensitivity (allergy) to any of the drugs (Baricitinib or Minoxidil). Serious active infections (such as HIV and hepatitis). Clinically important active, recurrent or chronic infection. Active tuberculosis. Severe neutropenia (less than 1000). Severe lymphopenia (less than 500). Anemia (hemoglobin less than 8g/dl). Cancer patients. History of deep vein thrombosis or pulmonary thromboembolism. Patients with an increased risk of intestinal perforation (with diverticular disease). Pregnant women. Breastfeeding women. Heart disease. Kidney disease. Liver disease. Patients with pheochromocytoma. Carriers of other causes of hair loss (folliculitis decalvans, folliculitis dissecans, lichen planopilaris and its variants, frontal fibrosing alopecia) or scalp dermatoses	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-76b23nf	Chronic insomnia: integrative approaches with auriculotherapy and laser acupuncture to improve sleep	Not yet recruiting	Intervention	2025-12-26	<NULL>	<NULL>	8683	Integrative and complementary health practices (PICS) in the management of chronic primary insomnia: auriculotherapy and systemic laser acupuncture	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-01	Universidade Federal do Maranhão	<NULL>	<NULL>	<NULL>	Age between 18 and 70 years; male and female gender; with spontaneous complaint of insomnia; agree to participate in the research by signing the Informed Consent Form; agree to provide a urine sample for biochemical and toxicological analyses; meet the clinical criteria for chronic insomnia as assessed in the anamnesis; receive diagnostic confirmation of chronic insomnia from a medical professional who is part of the research team; be available to attend all treatment sessions uninterruptedly; obtain a score equal to or greater than 5 points on the questionnaire Pittsburgh Sleep Quality Index, Brazilian version	Pregnant women; smokers; history of chronic alcohol and drug use	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-9r2c367	Effect of Low-Intensity Strength Training with blood flow restriction on strength and muscle mass gains	Recruitment completed	Intervention	2025-12-26	<NULL>	<NULL>	8684	Effect of Low-Intensity Strength Training with blood flow restriction on the myofibrillar and extracellular areas of the muscle fiber	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-29	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	<NULL>	<NULL>	<NULL>	Not having performed strength training - ST in the six months prior to the start of the intervention; presenting adequate physical conditions for the practice of exercise; not having musculoskeletal injuries in the lower limbs or neuromuscular disorders that could compromise the execution of the proposed protocols; both sexes; ages between 18 and 35 years	Cardiac symptoms; diabetes; arrhythmias.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10t8dj3b	Comparison of different types of implants in various clinical situations and loading protocols - Ongoing clinical study	Not yet recruiting	Intervention	2025-12-24	<NULL>	<NULL>	8681	Comparative evaluation of different implant designs in various clinical situations and loading protocols. a prospective clinical trial	<NULL>	n/a, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Male and female patients; Patients aged between 18 and 75 years; Patients in good general health (physical and mental) at the time of surgery; Patients who provide free and informed consent	Patients who smoke; Patients with a known history of current alcohol, drug, or medication abuse; Patients with systemic non-controlled diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-29x7rhy	A comparative study between a modified traditional transscleral cyclophotocoagulation technique and the current standard technique in eyes with refractory glaucoma	Data analysis completed	Intervention	2025-12-24	<NULL>	<NULL>	8682	A prospective, randomized, comparative, examiner-masked study comparing a modification of the traditional transscleral cyclophotocoagulation technique with slow coagulation in eyes with refractory glaucoma	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Goiás	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; patients of any gender; patients who have undergone previous surgical interventions for glaucoma or not (excluding cyclodestructive procedures); patients previously operated on for glaucoma who experienced failure of such procedure(s) and did not achieve target intraocular pressure under maximally tolerated medication at medical discretion; patients with other subtypes of glaucoma classified as refractory glaucoma, such as neovascular glaucoma, glaucoma in aphakic eyes, inflammatory glaucoma, glaucoma associated with corneal transplant, post-vitreoretinal surgery glaucoma (with or without silicone oil implant), post-traumatic glaucoma; patients with glaucoma in eyes with conjunctiva unsuitable for filtering surgeries; patients with absolute glaucoma and a history of pain associated with marked ocular hypertension	Pregnant patients; lactating patients; patients with unknown or non-glaucoma related vision loss/deficit in any eye; history of previous cyclodestructive surgery; patients with a history of corneal refractive surgery; glaucoma with active uveitis; patient&apos;s inability to return on scheduled dates; patient&apos;s refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-66tbzr4	How teriparatide works in alveolar bone healing	Data analysis completed	Intervention	2025-12-23	<NULL>	<NULL>	8677	Understanding the effects of teriparatide on alveolar bone repair	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-05-04	Universidade Federal Fluminense	<NULL>	<NULL>	<NULL>	Individuals aged18 years or older; clinically healthy; with an indication for bilateral extraction of premolars and/or molars (from the same or different arches); with the presence of teeth adjacent to the teeth to be extracted and who agreed to participate in the study by signing the Informed Consent Form; Teeth with an indication for extraction without viability of rehabilitation	Presence of acute periapical or periodontal infection; serious systemic diseases; current use of medications such as chemotherapeutic agents, anticoagulants, corticosteroids, anti-resorptive agents (such as bisphosphonates and RANKL modulators) or immunosuppressants; decompensated chronic diseases (including hypertension, diabetes, rheumatological, renal or hepatic diseases); metabolic bone diseases (such as osteomalacia, hypocalcemia or hypercalcemia); motor limitations that compromise oral hygiene; active smoking (or ex-smokers with less than six months of cessation); pregnancy or history of radiotherapy in the last five years	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-5bdqznf	Effects of Positive Expiratory Pressure on Airways in Infants with Pneumonia	Not yet recruiting	Intervention	2025-12-23	<NULL>	<NULL>	8678	Effects of Airway Positive Expiratory Pressure (PEP) on Respiratory Distress and Secretion Volume in Hospitalized Infants with Pneumonia: protocol for a randomized, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Ciências da Saúde do Trairi - Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Infants aged between 29 days and 2 years; hospitalized in pediatric wards with a clinical diagnosis of pneumonia; parents or legal guardians accompanying the infants during hospitalization aged 18 years or older	Infants with chronic respiratory conditions; congenital heart disease; malformations of the thoracic cage and or upper airways; associated acute respiratory diseases such as acute viral bronchiolitis, tuberculosis or pertussis; neurological disorders; hemodynamic instability; need for invasive or noninvasive mechanical ventilation at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-48z43w9	Effects of non-invasive brain stimulation on brain and muscle activity in people with amyotrophic lateral sclerosis	Not yet recruiting	Intervention	2025-12-23	<NULL>	<NULL>	8679	Effects of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on different cortical areas on neural connectivity, cortical excitability, and muscle activity in individuals with amyotrophic lateral sclerosis: a proof-of-concept study.	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Departamento de Fisioterapia	<NULL>	<NULL>	<NULL>	Individuals diagnosed with amyotrophic lateral sclerosis according to the Gold Coast criteria; age between 18 and 80 years; both sexes; adequate cognitive performance defined by a score ≥17 on the ALS Cognitive Behavioral Screen; ability to perform functional movements of the upper limbs; neurotypical individuals without a diagnosis of neurological disease; age between 18 and 80 years; both sexes; adequate cognitive performance defined by a score ≥17 on the ALS Cognitive Behavioral Screen; ability to perform functional movements of the upper limbs	Presence of neuropsychiatric disorders; history of seizures or epilepsy; history of traumatic brain injury; presence of metallic clips, pacemakers, or deep brain stimulation implants; history of neurosurgery; alcohol abuse or drug dependence	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10d8nkrv	Effects of Cryofrequency on Facial Rejuvenation	Data analysis completed	Intervention	2025-12-23	<NULL>	<NULL>	8680	Effects of Cryofrequency on the Treatment of Facial Skin Aging Signs	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-07	Universidade Estadual de Goiás	<NULL>	<NULL>	<NULL>	Women over 35 years of age; who present facial characteristics of aging such as fine dynamic and static wrinkles; sagging and loss of facial tone; who seek the services and aesthetics of the Aesthetics and Cosmetology course at the State University of Goiás and agree to participate in the study	Women who have undergone recent cosmetic treatment (within the previous 6 months); those with a history of abnormal scarring (keloid or hypertrophic scar); inflammatory skin disease; cardiovascular disease; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10s8qxy8	Analysis of implants with different designs over 10 years of follow-up	Recruitment completed	Intervention	2025-12-22	<NULL>	<NULL>	8674	Analysis of the microbiome and proteomics of peri-implant crevicular fluid associated with healthy and peri-implantitis-affected implants, comparing different implant designs - A randomized, controlled, double-blind trial in a split-mouth model with 10-year follow-up	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2012-02-01	Associação Salgado de Oliveira de Educação e Cultura	<NULL>	<NULL>	<NULL>	Clinically healthy patients; Both genders; Age between 18 to 70; Completely edentulous patients; Dental extractions performed more than 6 months previously	Patients with alcohol, drug or medication abuse; Smokers or those with systemic diseases, such as uncontrolled diabetes; Coagulation disorders; Severe cardiac vascular disorders and other significant illnesses	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-3kprqcz	Use of personal care formulations for the control of gingivitis and dental hypersensitivity	Not yet recruiting	Intervention	2025-12-22	<NULL>	<NULL>	8675	Gingival status and dentin hypersensitivity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Faculdade de Odontologia	<NULL>	<NULL>	<NULL>	Men and women, aged 18 to 75 years; At least 20 natural permanent teeth; Good general systemic health as determined by the study investigators; Presenting two teeth (incisors, canines, premolars or 1st molar) with a qualified response to the stimulus of a jet of cold air applied per second to the cervical surface, with a score of 2 or 3, according to the scoring defined on the Schiff Cold Air Sensitivity Scale and a gingival index greater than 1, according to the Löe and Silness index); Presenting gingival inflammation.	Individuals who smoke; Pregnant women; Individuals using systemic medications; Development of a medical condition and/or use of medication that may affect the study results; Periodontitis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-10wjzrt7	Effect of intervention with exercises and pain neuroscience education on physical, cognitive, and emotional function and gait parameters of elderly people with and without knee osteoarthritis: a randomized clinical trial	Not yet recruiting	Intervention	2025-12-22	<NULL>	<NULL>	8676	Effect of intervention with multicomponent exercises and pain neuroscience education on physical, cognitive, psychoemotional function and gait parameters of elderly individuals with and without Knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-31	Obras Socias e Educacionais de Luz	<NULL>	<NULL>	<NULL>	Age between 60 and 80 years; female and masculine gender; diagnosis of Medial Femorotibial Osteoarthritis confirmed by X-ray examination; grade 2 or 3 Knee Osteoarthritis according to the Kellgren and Lawrence criteria	Diagnosis of Osteoarthritis in the Hip and/or Ankle; grade 4 Osteoarthritis in one or both knees; body mass index less than 35 kg/m²; presence of Vestibulocochlear Diseases; uncontrolled Cardiac or Respiratory Arrhythmias; Convulsive Syndrome; Musculoskeletal Disorders with functional limitation, such as Diabetic Neuropathies and Cutaneous Ulcers of any etiology; use of Prostheses or Orthoses in the lower limbs; Fractures in the last six months; presence of Dementia; inability to Walk independently; being under Physical Therapy treatment concurrently with the intervention period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-8bwn97b	Effect of Laser on Pain and Movement in People with Problems in the Jaw Region	Recruiting	Intervention	2025-12-19	<NULL>	<NULL>	8669	Effect of Photobiomodulation on Pain Intensity and Mobility in Individuals with Temporomandibular Dysfunctions	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-04	Universidade São Francisco	<NULL>	<NULL>	<NULL>	Age between 18 and 50 years; both genders; report pain greater than or equal to 4 on the Numerical Pain Scale (NPS greater than or equal to 4) in the temporomandibular joint region, not requiring clinical diagnosis, for a period equal to or greater than 3 months intermittently, that is, with intervals in which the pain ceases; pain/discomfort in the masseteric region and head and neck, associated with pain in the temporomandibular joint region, for a period equal to or greater than 3 months intermittently, that is, with intervals in which the pain ceases	Use any type of anti-inflammatory medication; use any type of orthodontic retainer plates	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-7dx6s84	Acute effect of breaking up prolonged sitting time with two different intensities on cardiovascular parameters and muscle activity: a randomized crossover clinical trial	Recruitment completed	Intervention	2025-12-19	<NULL>	<NULL>	8670	Cardiometabolic and cardiovascular responses, strength, and muscle electrical activity during multistage sitting time in adults	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-09	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Healthy adults aged 18 to 59 years; regularly enrolled as university students; with no diagnosis of chronic diseases; no continuous use of medications or any ergogenic aid; and no injuries or conditions that would prevent prolonged sitting or walking	Failure to complete any stage of the study; including screening, baseline assessments; or any of the experimental sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-2vqkk95	Promoting emotional weel-being among workers - Apice Project	Not yet recruiting	Intervention	2025-12-19	<NULL>	<NULL>	8671	Effectiveness of an intervention to promote psychological well-being and reduce symptoms associated with common mental disorders in workers - Apice Project	<NULL>	n/a, single-arm-study, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Fundação Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Workers; both sexes; 18 years of age or older, or emancipated; currently employed; agrees to participate in the study	Workers on leave; workers who do not complete the filling out of the forms	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-7d4ff6q	Analysis of the effects of adding Pregabalin to the treatment of postoperative pain control in Hemorrhoid Surgery	Recruiting	Intervention	2025-12-19	<NULL>	<NULL>	8672	Efficacy of Pregabalin as an adjuvant in multimodal pain control after Hemorrhoidectomy	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-08	Escola Paulista de Medicina da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	ASA 1 to 3 by the American Society of Anesthesiology; ages between 18 and 65 years; of both sexes; with grade III or IV hemorrhoidal disease indicated for Milligam-Morgan hemorrhoidectomy	Patients with cardiac arrhythmias; cardiomyopathy and/or cardiac conduction disorders; psychiatric, liver, respiratory, or oncological diseases; cognitive impairments that prevent proper completion of the forms; using analgesics in the week prior to surgery; associated surgeries; hypersensitivity to medications; active user of psychoactive drugs; consent forms signed incorrectly or without signature	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-357dht4	Actions to Improve Well-Being and Reduce Emotional Problems at Work	Not yet recruiting	Intervention	2025-12-19	<NULL>	<NULL>	8673	Effectiveness of Interventions to Promote Psychological Well-Being and Reduce Common Mental Disorders among Workers	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-02	Fundação Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Workers of both sexes; aged 18 years or older or emancipated; active employment link in one of the selected industrial sector companies distributed across the Regional Departments of the Social Service of Industry; signature of the Informed Consent Form	Absence from work activities due to vacation or leave of any kind during the data collection period; non-completion of the data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-2y2jnn8	The effects of Laser application on acupuncture points on pain and heart rate variability in women with Fibromyalgia	Not yet recruiting	Intervention	2025-12-18	<NULL>	<NULL>	8662	Effects of Laser application on HEGU (LI4) and TAICHONG (LR3) acupoints on pain and heart rate variability in women with Fibromyalgia: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Women aged 30 to 70 years; belonging to AGFESC; residing in municipalities within the AMREC, AMESC, and AMUREL regions; who have a prior medical diagnosis of fibromyalgia; chronic pain with a score equal to or greater than four on the Visual Analogue Scale (VAS); are available to participate in all stages of the study, including intervention sessions and assessments; and express their agreement to participate by signing the Informed Consent Form (ICF)	Women who present with active skin lesions at the laser application sites, such as open wounds or ulcerations; clinical conditions that contraindicate the use of phototherapy, such as active malignant neoplasms; inflammatory dermatological diseases at the application sites, such as psoriasis or dermatitis; decompensated or inadequately treated psychiatric disorders; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-5k7skcy	Evaluation of the effectiveness of an Intervention to reduce toxic masculinity in adolescence	Recruiting	Intervention	2025-12-18	<NULL>	<NULL>	8663	Reflecting on what it means to be a Man	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-13	Faculdade de Ciências Medicas da Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Male adolescents; aged 14 to 19; enrolled in secondary education at the participating educational institutions	Male students; aged 20 years or older; who are not enrolled in secondary education; from the participating schools; female students; from the participating schools	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-38vmd97	Treatment of Bleeding in users of Contraceptive Implants (Implanon) with Ulipristal Acetate	Not yet recruiting	Intervention	2025-12-18	<NULL>	<NULL>	8664	Randomized, experimental study of the use of oral Ulipristal Acetate as a treatment for Abnormal Uterine Bleeding in women using the Etonogestrel Contraceptive Implant (Implanon)	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	<NULL>	<NULL>	<NULL>	Women aged 18-45; etonogestrel implant users who experience prolonged or recurrent abnormal bleeding (bleeding lasting more than 14 days or episodes with intervals of less than 24 days)	Pregnant women; women who have given birth within the last six months, breastfeeding women; women with abnormal uterine bleeding of unknown cause prior to placement of the ENG implant; women with known pre-existing liver disease, women with blood dyscrasias; users of anticoagulants; users of medication that contraindicates the use of Ulipristal Acetate (vinblastine, digoxin, quinidine, dabigatran etexilate, phenytoin, barbiturates, loperamide, oxycarbamazepine, carbamazepine, rifampicin, griseofulvin, topiramate)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-2h2pmbd	Supplementation with beneficial bacteria (Lactobacillus casei) to control blood sugar in people with obesity.	Data analysis completed	Intervention	2025-12-18	<NULL>	<NULL>	8665	Effect of Lactobacillus casei supplementation on the glycemic profile of obese patients: a randomized, double-blind, placebo-controlled clinical trial.	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-09	Fundação Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Adult patients up to 59 years of age, of both sexes, will be included; obese with a Body Mass Index (BMI) greater than or equal to 30 kilograms per square meter (kg/m²); followed by the Nutrition Clinic of the University Hospital of Aracaju/Sergipe	Patients who are pregnant; using corticosteroids, antimicrobials and/or prebiotic, probiotic or synbiotic supplements during the study; and who have a diagnosis of inflammatory bowel disease, celiac disease, lactose intolerance, or intestinal resections will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-107kny5q	Training of the non-operated leg and its effects on knee recovery after anterior cruciate ligament surgery	Not yet recruiting	Intervention	2025-12-18	<NULL>	<NULL>	8666	Effects of Contralateral Strength Training After Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Federal de Ciências da Saúde de Porto Alegre	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 18 and 40 years; patients with anterior cruciate ligament reconstruction surgery scheduled during the data collection period	Failure to attend the preoperative assessment session; initiation of the rehabilitation program more than three days after surgery; presence of injuries associated with anterior cruciate ligament rupture that prevent partial weight bearing during the first postoperative week due to medical indication or participant inability or unwillingness	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-2pvqfdd	Clinical and functional outcomes of passive manual joint movements in intubated patients under invasive mechanical ventilation	Recruiting	Intervention	2025-12-18	<NULL>	<NULL>	8667	Clinical and functional outcomes of Passive Joint Mobilization in patients undergoing invasive mechanical ventilation	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-02	Hospital Universitário da Universidade Federal do Maranhão	<NULL>	<NULL>	<NULL>	Patients aged eighteen years or older will be included in the study; patients of both sexes; patients on invasive mechanical ventilation for more than twenty four hours; patients presenting a sedation level between minus three and minus five according to the Richmond Agitation Sedation Scale; patients whose legal guardian agrees to participation through signing the Free and Informed Consent Form	Patients who remain under sedation with a Richmond Agitation Sedation Scale score between minus three and minus five will be excluded; patients who are unable to perform active activities will be excluded; patients who upon awakening do not agree to participate in the study will be excluded; patients whose legal guardian decides to withdraw consent will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-6kj2h9d	Motivation and physical activity during ageing	Data analysis completed	Intervention	2025-12-18	<NULL>	<NULL>	8668	Motivational aspects for physical activity in the ageing process	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade do Oeste de Santa Catarina	<NULL>	<NULL>	<NULL>	Female sex; age equal to or older than sixty years; no prior participation in a structured exercise program; clinical fitness to participate in physical exercise as confirmed by medical clearance; understanding of and agreement with the study procedures; signing of the informed consent form	Failure to complete pre- or post-intervention assessments; lack of medical clearance for participation in physical exercise; presence of medical conditions that preclude participation in physical exercise; significant changes in dietary habits during the study period; withdrawal from the intervention program during the follow-up period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-3yxrgtz	Use of Bone Marrow to reduce pain and improve mobility in Hip Osteoarthritis	Not yet recruiting	Intervention	2025-12-17	<NULL>	<NULL>	8660	Clinical efficacy of Intra-articular Injection of Bone Marrow Aspirate (BMA) and Bone Marrow Concentrate (BMAC) in the treatment of Hip Osteoarthritis: a triple-blind, randomized, controlled clinical trial	<NULL>	2, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Fundação Arnaldo Vieira de Carvalho	<NULL>	<NULL>	<NULL>	Volunteers; both genders; age of 18 years or older; with a confirmed diagnosis of hip osteoarthritis Tönnis grades 1 or 2; pain score greater than or equal to 4 on the visual analog scale; duration of visual analog scale pain for a minimum of 3 months; failure of previous conservative treatment	History of previous surgeries on the affected hip; previous episodes of joint infection; immunocompromiseds diagnosed with active autoimmune diseases; coagulation disorders diagnosis; predominant presence of neuropathic pain with a score greater than or equal to 4 on the Douleur Neuropathique 4 (DN4) questionnaire	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-5dnpdgn	Pelvic Muscle Training in Women with Urinary Incontinence During Running	Not yet recruiting	Intervention	2025-12-17	<NULL>	<NULL>	8661	Training of Conventional or Coordinated Pelvic Floor Muscles in Female Runners with Stress Urinary Incontinence: A Randomized Clinical Trial	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-15	Faculdade de Educação Física e Fisioterapia	<NULL>	<NULL>	<NULL>	Female volunteers; runners; clinical presentation of urinary incontinence during running; age over 18 years.	Volunteer pregnant women; active urinary tract infection; diagnosis of neuromuscular diseases that compromise bladder function; history of pelvic or perineal surgeries to correct pelvic floor dysfunctions; pelvic prolapse; women who have previously undergone physiotherapy focused on treating dysfunctions of these muscles	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-6gx95tt	Effects of Therapeutic Taping on the lips of children with Trisomy 21	Not yet recruiting	Intervention	2025-12-16	<NULL>	<NULL>	8657	Therapeutic Taping effects on lip seal in children with Trisomy 21: comparison between Inelastic, Elastic, and Hyperelastic Tapes  a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Present Trisomy 21; be at least 2 years and at most 6 years old; not have complete lip sealing in the habitual position;  not be undergoing speech therapy for orofacial motor function.	Presence of other associated syndromes; craniofacial malformations; allergic reactions to the use of the bandage; skin lesions in the area where the bandage is applied.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-7v542b9	How Education and Technology help Children use Inhalers correctly	Recruiting	Intervention	2025-12-16	<NULL>	<NULL>	8658	Impact of Educational and Monitoring Technology use on the effectiveness of Inhalation Therapy using Pressurized Inhalers in Pediatric	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Municipal de São Caetano do Sul	<NULL>	<NULL>	<NULL>	Children aged between 4 and 14 years. Of both sexes. With a diagnosis of Asthma and a prescription for inhalation therapy with pressurized metered-dose inhalers (MDI) with spacers. Authorization and Informed Consent Form signed by the legal guardian. Access to the OxyKids application (smartphone or tablet)	Patients exclusively using conventional nebulizers or dry powder inhalers (DPI). Children with severe respiratory comorbidities (for example: cystic fibrosis, bronchopulmonary dysplasia). Unavailability of digital access or refusal to use the application. Absence of legal guardian consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-23cg7hc	Comparison between two surgical access techniques for Tibia Fracture treatment	Recruitment completed	Intervention	2025-12-16	<NULL>	<NULL>	8659	Transpatellar vs Lateral Parapatellar approach in the Treatment with Tibial Intramedullary Nails	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-03	Hospital do Trabalhador	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older. Both sexes. Tibial shaft fractures classified as AO/OTA 42. Indication for treatment with locked intramedullary nailing. Ability to comply with follow-up. Signed informed consent form	Open fractures classified as Gustilo-Anderson type IIIB or IIIC. Prior surgery on the affected knee or tibia. Previous or concurrent fasciotomy. Significant associated injuries except ipsilateral fibula fracture. Preexisting degenerative joint disease. Inability to comply with follow-up. Loss to follow-up before 12 weeks	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-9z5gqp7	Study on the effects of Relaxing Massage and Myofascial Release in people with Fibromyalgia	Recruiting	Intervention	2025-12-15	<NULL>	<NULL>	8653	Effects of Relaxing Classical Massage and Myofascial Release in people with Fibromyalgia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Federal do Triângulo Mineiro	<NULL>	<NULL>	<NULL>	Female sex; age equal to or greater than 18 years; diagnosed with Fibromyalgia	Failure to perform the evaluation protocol; failure to sign the consent form; contraindication to the techniques of relaxing classical massage and myofascial release; undergoing treatments involving any of the proposed techniques; lack of adherence to treatment sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-87qssmm	Research investigates the relationship between chronic rhinitis and cognitive impairment in the elderly	Not yet recruiting	Observational	2025-12-15	<NULL>	<NULL>	8654	Investigation of the Impact of Chronic Rhinitis on Cognitive Decline in Older Adults	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Escola Paulista de Medicina	<NULL>	<NULL>	<NULL>	Men and women aged 60 to 70 years with and without a previous diagnosis of chronic rhinitis; Literate; Absence of neurological diseases; No other serious psychiatric disorders, such as schizophrenia and bipolar disorder; No diagnosis of substance use disorder	Refusal to participate in or perform any of the proposed activities; Omission of answers in tests essential for the analysis; Lack of progress or withdrawal during the evaluation process; Occurrence of incidents that prevent continued participation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-2pzz8fx	Long-term effects of functional training in the prevention of heart problems in women with Breast Cancer undergoing Chemotherapy: randomized clinical trial	Recruitment completed	Intervention	2025-12-15	<NULL>	<NULL>	8655	Chronic effects of functional training on the prevention of subclinical cardiotoxicity in women ith Breast Cancer undergoing Chemotherapy: a randomized clinical trial	<NULL>	n/a, non-randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-04	Programa de Pós-Graduação em Educação Física - PPGEF	<NULL>	<NULL>	<NULL>	Women diagnosed with HER2+ breast cancer (negative, positive, and/or triple positive for hormonal receptors);aged between 18 and 50 years;chemotherapy treatment conducted with monoclonal antibodies and/or their derivatives with the first cycle completed or ongoing;who have medical clearance to undergo the intervention protocol;normocardic;normotensive;with a ventricular ejection fraction above 50%;sedentary in the last three months prior to the start of the intervention protocol;without cognitive; functional;neuronal deficits;signing the informed consent form (ICF)	Women who have other types of diagnosed neoplasms;with metastatic lesions;who have undergone bilateral mastectomy;who receive chemotherapy treatment with anthracyclines alone;who change the type of chemotherapy during the application of the intervention protocol;who undergo only radiotherapy and/or hormone therapy;women with a diagnosis of previous cardiovascular disease;who have more than 25% absence in the intervention protocol;and those who die during the course of the protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-99jm83b	Use of Sodium Ascorbate before Restoration after Tooth Bleaching and its Impact on the Retention of Restorations in Cervical Lesions	Recruiting	Intervention	2025-12-15	<NULL>	<NULL>	8656	Does the application of Sodium Ascorbate before immediate post-bleaching Restoration affect the retention rate of Composite Resin Restorations in Cervical Lesions? A randomized, controlled, double-blind, non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Estadual de Ponta Grossa (UEPG)	<NULL>	<NULL>	<NULL>	Good general health status according to the American Society of Anesthesiologists classification system — ASA I or ASA II. Minimum age of 18 years. Both sexes. Acceptable oral hygiene without periodontal disease. Presence of at least 20 teeth in occlusion. Presence of at least six upper and lower anterior teeth free of caries, restorations, or endodontic treatment. Canine color A2 or darker according to the VITA Classical shade guide. Presence of three non-carious cervical lesions comparable in size, shape, dimensions, and color. Non-retentive lesions, deeper than 0.5 mm, involving enamel and dentin, in vital teeth extending up to the second premolar in any mandibular or maxillary arch	Cavosurface margin involving more than 50% of the enamel. Use of orthodontic appliances or dental prostheses. Severe tooth discoloration such as tetracycline stains, fluorosis or non-vital teeth. Poor oral hygiene with Oral Hygiene Index–Simplified (OHI-S) score greater than 3. Severe or chronic periodontitis with probing depth greater than 4 mm, bleeding on probing and clinical attachment loss greater than 3 mm in more than four teeth. Severe bruxism with significant masticatory muscle pain, temporomandibular joint pain or extensive tooth wear. Known allergy to resin-based materials, bleaching agents or substances used in the study. Pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-106z8dng	Home Exercises for Knee Pain	Recruiting	Intervention	2025-12-13	<NULL>	<NULL>	8652	A Randomized Clinical Trial to Improve Clinical Outcomes and Increase Adherence of patients with Patellofemoral Pain Undergoing an Unsupervised Home Exercise Program	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Estadual Paulista - Faculdade de Ciências e Tecnologia - Câmpus de Presidente Prudente	<NULL>	<NULL>	<NULL>	Anterior knee pain during at least two of the following activities; prolonged sitting; squatting; kneeling; running; ascending stairs; descending stairs; jumping; landing. Onset of symptoms must be insidious in one or both knees and have lasted at least 3 months. Minimum mean value of worst knee pain in the previous month of 30 mm on a Visual Analogue Scale (VAS) ranging from 0 to 100 mm	Failure to complete any stage of data collection; development of clinical evidence of any other knee disorder during the course of the project; suffering traumatic knee injury; to undergo knee joint surgery during project execution	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-3gw2nms	Immediate effects of the Contemporary Belting Method in actresses	Recruiting	Intervention	2025-12-12	<NULL>	<NULL>	8649	Immediate effects of the Contemporary Belting Method on the voice of theater actresses with and without vocal complaints: Randomized Clinical Trial	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	UNIVERSIDADE FEDERAL DE MINAS GERAIS	<NULL>	<NULL>	<NULL>	Active female gospel singers; aged between 18 and 50 years; with more than one year of experience in gospel singing	Smoking singers; with self-reported vocal complaints; during menstrual period; self-report of disease of cardiovascular origin, hormonal, neurological disease; presence of cleft lips or palate; facial or rib fractures; diagnosed with dysphonia; with vocal complaints; with hearing complaints; diagnosed with hearing loss; with upper airway infection at the time of evaluation; singers in speech therapy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-2vz87ym	Assessment of quality of life and functionality in patients with Solid Tumors undergoing Physiotherapy Treatment	Recruiting	Intervention	2025-12-12	<NULL>	<NULL>	8650	Assessment of quality of life and functionality in patients with Solid Tumors undergoing chemotherapy and/or radiotherapy with or without Physiotherapy Intervention: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Centro Universitário Faculdade de Medicina do ABC	<NULL>	<NULL>	<NULL>	A recent cancer diagnosis, being over 18 years old, undergoing chemotherapy and/or radiotherapy, the ability to understand and follow study instructions, providing consent to participate in the trial	Patients with severe physical limitations, patients undergoing physiotherapy treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-10wr3pqb	Rapid maxillary expansion: comparison between the invisalign palatal expander system and the hyrax appliance	Not yet recruiting	Intervention	2025-12-12	<NULL>	<NULL>	8651	Rapid maxillary expansion: comparison between the invisalign palatal expander and the hyrax appliance	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-15	Universidade do Estado do Rio de Janeiro - UERJ	<NULL>	<NULL>	<NULL>	Age between 6 and 12 years; both sexes; mixed dentition stage; Class I or Class II molar relationship, or straight/mesial step in the primary dentition; cervical vertebral stage 1 or 2 (CVS methods 1–2); unilateral or bilateral posterior crossbite, involving primary or permanent teeth; patients diagnosed with transverse maxillary deficiency, characterized by a skeletal transverse discrepancy measured from the estimated center of resistance of the first molars ≤ –3 mm	Previous orthodontic treatment; patients with skeletal Class III; dental agenesis or presence of supernumerary teeth; craniofacial abnormalities; maxillary tooth impaction; presence of palatal torus; history of dental trauma, including avulsion and alveolar/maxillary fracture; refusal to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:59
RBR-9ngd4mm	Effectiveness of Interpersonal Relationships in Anxiety Situations (RIA) in Primary Health Care: A Randomized Clinical Trial	Recruitment completed	Intervention	2025-12-11	<NULL>	<NULL>	8642	Mental health and psychosocial care during the Covid 19 outbreak: proposal for a telephone based intervention program for controlling anxiety and reducing alcohol consumption	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-01	Secretaria Municipal da Saúde de São Paulo	<NULL>	<NULL>	<NULL>	to be male or female; to be over 18 years old; to have attended a consultation at the Basic Health Unit (BHU); to have sufficient proficiency in the Portuguese language to understand the interviewer’s questions; to have a score equal to or greater than 11 on the simplified 6-item State-Trait Anxiety Inventory (STAI-S6); to be available for follow-up	undergoing treatment for problems related to alcohol use and/or other mental disorders; patients who show noticeable signs of mental confusion or intoxication by psychoactive substances during the phone call; the hearing impaired; patients who refuse to receive the intervention and/or follow-up	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-28khn86	Relationship between Bruxism, tooth wear, anxiety and depression, and sleep quality in dental students	Recruitment completed	Observational	2025-12-11	<NULL>	<NULL>	8643	Correlation between bruxism, dental wear, emotional aspects, and sleep quality in dental students: a prospective cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Estadual de Maringá	<NULL>	<NULL>	<NULL>	A convenience sample will be gathered, which will include: Dentistry students at the State University of Maringá; aged between 18 and 35 years old; with at least 20 teeth in occlusion.	Individuals who use orthodontic appliances; presence of crossbite or deep bite; teeth that require extraction; carious lesion; periodontal disease; unsatisfactory restoration; individuals with gastroesophageal reflux disease.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-99tjfz5	Promoting Maternal Mental Health Through the Online PROMATER Program	Not yet recruiting	Intervention	2025-12-11	<NULL>	<NULL>	8644	Promoting Maternal Mental Health: Development and Evaluation of the Online PROMATER Program	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)	<NULL>	<NULL>	<NULL>	Brazilian women; age 18 years or older; internet access via computer, smartphone or tablet; pregnant women with more than thirteen weeks of gestation or up to six months postpartum	Current severe psychiatric diagnosis, such as psychotic episode, bipolar disorder in the acute phase or substance use disorder, according to self-report	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-696v3km	The path a woman with breast cancer takes in the public health system (SUS): from the first sign of the disease to the start of treatment	Recruiting	Observational	2025-12-11	<NULL>	<NULL>	8645	Patient journey with breast cancer in the care pathway of the Unified Health System (SUS): time elapsed from the first symptom to treatment	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Empresa Brasileira de Serviços Hospitalares - EBSERH	<NULL>	<NULL>	<NULL>	Women aged 18 years or older who agree to participate in the project and sign the Informed Consent Form -ICF; residing in municipalities within the state of Goiás; users of the Brazilian Unified Health System - SUS; diagnosed with breast cancer; referred for initiation of treatment at the Advanced Breast Diagnosis Center of the Hospital das Clínicas of the Federal University of Goiás -CORA-HC/UFG; and who began treatment at least six months prior	Women who do not meet the inclusion criteria; who decline to participate in the study; or who present physical or cognitive limitations that restrict their ability to take part in the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-104rgrk4	Recovery of Gait in Patients Who Have Suffered a Stroke Using Robotic Technologies and Brain Stimulation	Not yet recruiting	Intervention	2025-12-11	<NULL>	<NULL>	8646	Neuromodulation with Transcranial Magnetic Stimulation Combined with a Motor Imagery-Based Brain–Computer Interface and Neurofeedback on a Motorized Treadmill for Gait Recovery in Post-Stroke Patients	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Centro de Reabilitação Física do Espírito Santo (CREFES)	<NULL>	<NULL>	<NULL>	Over 18 years of age; patients with gait dysfunction resulting from stroke; clinically stable; good understanding and ability to follow the researchers’ instructions; willing to participate in the study and sign the informed consent form	Clinical instability; inability to maintain orthostasis; use of a pacemaker; uncontrolled epilepsy; skin disease at the stimulation site; lower limb orthopedic condition that limits gait; severe osteoporosis; score of grade 4 on the Ashworth Scale (fixed muscle/joint contracture) in the lower limb; lower limb amputation; active vascular thrombosis in the lower limb; severe heart failure; inability to adapt to the motor imagery–brain–computer interface; decompressive craniectomy; severe cognitive impairment; severe visual impairment; severe hearing impairment; severe sensory impairment of the lower limbs; decompensated psychiatric disorder; severe dizziness; severe lower limb ataxia	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-7768cjd	Study on manual Therapy for Neck Pain and balance in students	Recruiting	Intervention	2025-12-11	<NULL>	<NULL>	8647	Effects of Manual Therapy techniques and Analysis of Postural control and Balance in university students with Nonspecific Neck Pain a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-29	Universidade de Brasília - Faculdade de Ceilândia	<NULL>	<NULL>	<NULL>	University students with complaints of neck pain; both genders; aged between 18 and 40 years; not using any controlled medication, except for contraceptives; not undergoing any type of physical therapy or similar treatment	Be pregnant; history of spinal fracture and/or surgery; history of tumor or cancer in the spine, pelvic organs, and/or gastrointestinal tract; skin problems such as mycoses, recent wounds, psoriasis, cuts, or dermatitis in general; physical impairments that prevent the performance of the proposed treatments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-28nhd4q	Effects of non-invasive Neuromodulation in the treatment of pain of people with advanced Cancer - a randomized controlled clinical trial focusing on an occupation of daily living	Not yet recruiting	Intervention	2025-12-11	<NULL>	<NULL>	8648	Effects of non-invasive Neuromodulation on pain management in people with advanced Cancer - randomized controlled clinical study focused on a daily life occupation	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-23	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	"Inclusion criteria: have a diagnosis of head and neck cancer (of the oral cavity, larynx
or pharynx), age between 18 and 75 years and a pain score of at least 4 points on a numerical pain scale (ranging from 0 to 10 points)"	Exclusion criteria: pregnancy and intracranial tumor and or metastasis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-6359s54	Evaluation of the effect of Dental Adhesive System in preventing Pigmentation of deciduous teeth after root canal treatment using a non-instrumental dental technique: a randomized clinical study	Recruiting	Intervention	2025-12-10	<NULL>	<NULL>	8639	Effect of the Adhesive System in preventing Coronary Pigmentation after non-instrumental endodontic treatment in primary teeth: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-14	Faculdade de Odontologia de Piracicaba	<NULL>	<NULL>	<NULL>	Children from the municipality of Votorantim (São Paulo, Brazil) who use the municipality&apos;s public dental service; children aged 5 to 9 years; children of both sexes; children who require endodontic treatment in at least one upper or lower deciduous molar, with a diagnosis of irreversible pulpitis or pulp necrosis; teeth with sufficient dental structure to allow absolute isolation of the operative field and subsequent restoration	Children who present any systemic alteration; history of allergic reaction to any medication; children who have used antibiotics in the last three months from the date of the examination; children with systemic manifestation (fever and extraoral abscess) resulting from the infectious process of dental origin; teeth that present obliteration of the pulp canal; involvement of the bone crypt of the permanent tooth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-6d5vscv	How the shape of root canal instruments affects pain after treatment: findings from a clinical study	Recruitment completed	Observational	2025-12-10	<NULL>	<NULL>	8640	Randomized Clinical Trial on the Influence of Instrument Taper and Design on the Occurrence and Intensity of Postoperative Pain in Endodontic Treatment	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Pontificia Universidade Católica de Campinas - PUC/ CAMPINAS	<NULL>	<NULL>	<NULL>	Posterior teeth (premolars or molars) indicated for endodontic treatment. teeth with vital pulp (living dental pulp). teeth requiring endodontic therapy for prosthetic purposes (as abutments for crowns or bridges). patients between 19 and 92 years old	Pulp necrosis (non-vital pulp). acute or chronic apical periodontitis. previously endodontically treated teeth. symptomatic or asymptomatic irreversible pulpitis. root resorption (internal or externalm incomplete root formation or open apical foramen. cases where apical patency cannot be established. patients with recent use of analgesics or anti-inflammatory drugs. which could interfere with pain perception	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-2jrv4ff	Development of Artificial Intelligence Models for predicting the evolution of Aging Patterns using Digital Biomarkers	Not yet recruiting	Intervention	2025-12-10	<NULL>	<NULL>	8641	Development of Artificial Intelligence Models for predicting the evolution of Aging Patterns using Digital Biomarkers	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	<NULL>	<NULL>	<NULL>	Participants must be 60 years of age or older, of either sex; have agreed to participate by signing the Informed Consent Form ICF or the Informed Assent Form IAF for individuals with greater difficulty understanding or associated cognitive impairment; and possess cognitive capacity that allows them to perform the tasks	Participants unable to understand and execute the specific instructions and commands of the intervention, including those with cognitive or behavioral deficits that prevent effective interaction with the games and tasks; individuals with severe visual or auditory impairments that prevent interaction with the extended reality interface, or unstable medical conditions that may compromise their safe participation; withdrawal from the study; failure to adapt to the proposed intervention protocol; use of medications or substances that significantly interfere with motor control; consecutive absences or absence from scheduled sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-7r2gzzq	Use of light to treat skin wounds in critically ill patients: a clinical study	Not yet recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8630	Photobiomodulation in the Treatment of Stage I Pressure Injury in Critically Ill Patients: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-31	Hospital de Clínicas de Porto Alegre	<NULL>	<NULL>	<NULL>	Clinical patients aged 18 to 75 years; regardless of gender; length of stay exceeding 24 hours in the ICU; stage 1 pressure ulcer developed during ICU admission; pressure ulcer identified during ICU admission (acquired in another unit); patients/companions who provide prior authorization through an informed consent form	Patients with coexisting dermatological diagnoses, such as burns, drug-related rashes, dermatitis, psoriasis; patients diagnosed with Fournier&apos;s and Stevens-Johnson syndromes; post-surgical patients (mobility contraindicated); patients with contraindicated changes in position; those who are hemodynamically unstable (patients using extracorporeal membrane oxygenation - ECMO or patients with adult respiratory distress syndrome - ARDS, prone position); patients who have already undergone photobiomodulation in the same injured area	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-8bzdzpb	Weightlifting for seniors: how it improves body movement, memory and protective factors in the blood	Recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8631	Effects of Strength Training on Physical and Cognitive Function and serum Bdnf levels in elderly people	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-26	Centro de Educação Física e Desportos da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Age 60 or older; both sexes; not practicing any type of regular and systematic physical exercise more than once a week during the six months prior to the start of the study; availability to participate in all stages of the research, walking independently and without difficulty in locomotion	Obtaining a score of 26 or less on the Montreal Cognitive Assessment (MoCA); having a musculoskeletal injury that prevents the performance of exercises; a history of severe cardiovascular and pulmonary diseases, metabolic disorders, and/or low visual acuity; having a training program attendance rate below 80% and/or missing four or more consecutive exercise sessions according to the records	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-648xyqn	The effects of Transcranial Photobiomodulation in children with Autism Spectrum Disorder	Not yet recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8632	Evaluation of the effects of Transcranial Photobiomodulation in children with Autism Spectrum Disorder: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Children diagnosed with mild Autism Spectrum Disorder (ASD); both sexes; between the ages of 7 and 10; residing in the greater Florianópolis region	Children undergoing treatment with psychotropic medications; diagnosed with another neurological dysfunction; or who have contraindications to laser treatment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-2bmnfbn	The use of aromatherapy to manage anxiety in the nursing staff	Data analysis completed	Intervention	2025-12-09	<NULL>	<NULL>	8633	Aromatherapy in the management of anxiety in nursing professionals in a specialized service	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-02	Universidade do Estado do Rio de Janeiro	<NULL>	<NULL>	<NULL>	The study participants were nursing professionals who work with adolescents and who wished to participate voluntarily, with time available to participate in the sessions	Those who present with allergies or hypersensitivity to the materials used, who discontinue therapy, and/or who fail to attend sessions will not be considered for sampling purposes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-7gtxkpt	Evaluation of products for the treatment of foot wounds in people with Diabetes	Not yet recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8634	Study of the efficacy and clinical tolerance of the products Cclf2023, Gclf2023, and Ndlf2023 in plantar Ulcers in diabetic patients	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Centro de Pesquisa Clínica do Hospital Universitário da Universidade Federal do Amapá	<NULL>	<NULL>	<NULL>	Adults aged 18 years and older; diagnosed with Type 1 or Type 2 Diabetes Mellitus; HbA1c ≤ 86 mmol/mol (10%) at screening; presence of a full-thickness ulcer below the ankle, with a duration of 6 weeks or more, and measuring between 1.0 and 5.0 cm² after debridement, without exposure of muscle, tendon, or bone; toe pressure ≥ 30 mmHg. Neuropathic and/or ischemic non-infected ulcer, at any stage of healing; change in ulcer area between screening and baseline within −30% to +25%; commitment to required care and no use of unauthorized products; ability to comply with the study protocol and to sign the informed consent form, including authorization for photographs	Pregnant or breastfeeding women; presence of an infected or highly exudative ulcer; indication for amputation; cognitive impairment; recent or current use of immunosuppressants, chemotherapy, or retinoids; unstable chronic diseases; hypersensitivity to components of the product; alcohol or drug abuse. Active Charcot deformity; inability or refusal to follow the protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-7r6n8zd	Global Integration Method (GIM): A study with children with autism using motor training with cognitive behavioral and narrative strategies	Recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8635	MIG (Global Integration Method): a randomized clinical trial of motor training mediated by cognitive, behavioral, and narrative grammar interventions for children with autism	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Instituto de Neurodesenvolvimento Cognição e Educação Inclusiva	<NULL>	<NULL>	<NULL>	Children aged 6 to 12 years at the start of the intervention; diagnosis of Autism Spectrum Disorder according to DSM-5 (APA, 2022); both sexes; support levels 1 or 2	Cognitive or behavioral changes, or medical conditions that prevent understanding of instructions or safe participation in activities; clinical conditions unsuitable for the use of the therapeutic garment proposed in the intervention protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-95f8kf8	Effectiveness of educational technology on father participation in labor, delivery, and birth	Not yet recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8636	Effectiveness of educational technology on paternal participation in labor, delivery, and birth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Maternidade Escola Assis Chateaubriand da Universidade Federal do Ceará	<NULL>	<NULL>	<NULL>	Minimum age of 18 years; be a partner and the companion of the parturient&apos;s choice; first experience in accompanying labor; have completed at least the fourth year of elementary school; and be accompanying nulliparous pregnant women, with a live fetus, at term, with a medical diagnosis of labor or antepartum rupture of the ovular membranes or hypertensive or postpartum syndromes, for induction of labor and who have an indication for vaginal delivery regardless of the obstetric outcome, which may be vaginal or cesarean section	Parturients in the expulsive stage; presenting a compromised physical or mental health condition that makes the research unfeasible; having participated in parenting and/or pregnancy courses; being a health professional; having the presence of doulas; parents with communication difficulties and stillbirth; giving up on continuing to participate in the study after the start of data collection; progressing to labor at the time of the approach; giving up or being unable to answer the proposed questions and stillbirth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-8v8j464	Efficacy of the use of Polypropylene Membranes in bone preservation after tooth extraction	Recruiting	Intervention	2025-12-09	<NULL>	<NULL>	8637	Effectiveness of using a Polypropylene Membrane in preserving the alveolar ridge after tooth extraction	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-01	Associação Pro Ensino Superior em Novo Hamburgo	<NULL>	<NULL>	<NULL>	Be over 18 years of age; both genders; voluntarily agree to participate in the study and sign the Informed Consent Form; have no allergies or intolerances to polypropylene; require extraction of a posterior tooth (premolar or molar); have no fistulas; not be undergoing orthodontic treatment; not use removable partial dentures that have support on the teeth adjacent to the tooth to be extracted; not be taking medications that interfere with bone remodeling processes (e.g., bisphosphonates); have adjacent teeth to the tooth to be extracted	Express interest in withdrawing from the study by revoking consent; present ridge characteristics that make membrane placement unfeasible after extraction; fail to attend the tomographic exams at the scheduled times; present complications after the extraction that require surgical reintervention or the prescription of antibiotics	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-4v9bq84	How Laser Application can help with Jaw Joint Pain	Recruitment completed	Intervention	2025-12-09	<NULL>	<NULL>	8638	Evaluation of Laserpunture in the treatment of Temporomandibular Dysfunction	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-17	Universidade Brasil	<NULL>	<NULL>	<NULL>	Volunteers aged between 20 and 59 years; of both sexes; with limited mouth opening or function; presence of pain in the masticatory muscles and/or temporomandibular joint (TMJ); pain during clenching or mandibular movements (muscular disorder of TMD, class Ia or Ib; or arthralgia, class IIIa), according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD); and who voluntarily agreed to participate in the study by signing the Informed Consent Form (ICF)	Volunteers who fall outside the age range established in the inclusion criteria; who have systemic disorders; who require continuous and/or frequent use of analgesics, anti-inflammatory drugs or antidepressants; who present any bone abnormality in the maxilla and/or mandible, such as TMJ arthropathy or rheumatoid arthritis; volunteers with a history of joint trauma, orthodontic treatment or who have received any form of TMD treatment in the last 6 months; pregnant women; patients with a fever on the day of attendance or thermography assessment; and volunteers who do not feel safe participating in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-7fy9gss	Benefício da Iodoterapia no Câncer de Tireoide com extensão e metástase no pescoço	Recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8623	Benefit of Adjuvant Therapy with I131 in patients with Differentiated Thyroid Carcinoma with minimal extrathyroidal extension and after re-operation for persistent or recurrent lymph node metastases	<NULL>	3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2017-01-01	Fundação Faculdade de Medicina	<NULL>	<NULL>	<NULL>	Patients with Differentiated thyroid carcinoma; minimal extrathyroidal extension; reoperation for persistent or recurrent lymph node metastases; aged over 18 years	Known distant metastases; distant metastasis diagnosed on whole-body scan with diagnostic I131	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3t7by45	Comparing treatments for fluid in the lungs: which is most effective?	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8624	CAPE-CHOICE: Comparative Results of Vasodilatory Strategies in Acute Pulmonary Edema	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Santa Casa de Misericórdia da Bahia	<NULL>	<NULL>	<NULL>	Patients with diagnosis of acute pulmonary edema in the emergency unit requiring vasodilator; age 18 years or older; both genders	Patients under 18 years of age; patients with cardiogenic shock; patients with acute coronary syndrome; patients with contraindication to any of the drugs; pregnant patients	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-64qvcwp	Treatment of Lower Back Facet Pain with Autologous Bone Marrow Aspirate	Recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8625	Autologous Bone Marrow Aspirate Injection for the Treatment of Chronic Lumbar Facet Joint Pain: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	HOME - Hospital Ortopédico e Medicina Especializada - LTDA	<NULL>	<NULL>	<NULL>	Participants aged eighteen years or older; chronic low back pain refractory to conservative treatment, including failure to respond to simple analgesics, nonsteroidal anti-inflammatory drugs, and adjunct therapies such as physical therapy and acupuncture; positive diagnostic test for facet syndrome, including worsening of low back pain during trunk extension after diagnostic facet block with lidocaine and pain relief equal to or greater than fifty percent on the visual analog scale within four hours after the block; confirmed diagnosis of facet syndrome by magnetic resonance imaging demonstrating facet arthritis or arthrosis	Presence of preexisting neurological deficit; rheumatologic disease; coagulopathy; pregnancy; allergy to local anesthetics; contraindication or adverse effects related to corticosteroid use; previous lumbar spine surgery; lumbar tumor; spondylolisthesis; low back pain without an identifiable cause	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-23bcd75	Sanitation in the occurrence of schistosomiasis	Recruiting	Observational	2025-12-08	<NULL>	<NULL>	8626	Evaluation of the effect of sanitation conditions on the occurrence of schistosomiasis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-23	Instituto René Rachou/Fundação Oswaldo Cruz Minas	<NULL>	<NULL>	<NULL>	Participants of both sexes; older than 7 years of age; participants who reside entirely in the community; community health workers who have been performing the function in the communities included in the study for at least 1 year; municipal coordinators of the Schistosomiasis Control Program	Pregnant or lactating women; individuals with impaired cognitive function or who cannot understand the study; individuals who cannot provide a collected stool sample due to a personal impediment; individuals who have been treated with Praziquantel for less than 6 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-68pry5j	How a Body Vibration Exercise Program Can Help Seniors Reduce the Risk of Falls and Improve Strength, Balance, and Fitness	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8627	Effect of Systemic Vibratory Therapy associated with a Physical Activity Program in Elderly Individuals on the Risk of Falls, Balance, Physical Conditioning and Neuromuscular Variables: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-10	Sociedade Unificada  de Ensino Augusto Motta	<NULL>	<NULL>	<NULL>	Older adults aged sixty years or older. both sexes. participants regularly enrolled in the Open University for Older Adults of the Augusto Motta University Center. ability to walk independently with or without an assistive device. availability to attend all intervention sessions. preserved cognitive ability to understand and follow instructions	Previous diagnosis of disabling neurological diseases. severe musculoskeletal disorders that prevent exercise performance. presence of a cardiac pacemaker or any implanted electronic device. recent orthopedic surgery in the lower limbs within the last six months. decompensated cardiovascular conditions. use of medications that significantly affect postural control. uncontrolled vertigo or vestibular disorders. medical conditions that contraindicate exposure to mechanical vibration	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-6h6k6mt	How metformin use may influence bone marrow fibrosis	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8628	Evaluation of the effects of metformin treatment on the process of myelofibrosis	<NULL>	2-3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Centro de Hematologia e Hemoterapia da Unicamp – Hemocentro da UNICAMP	<NULL>	<NULL>	<NULL>	Eligible patients will be those diagnosed with myeloproliferative neoplasm (MPN) according to WHO criteria confirmed by at least two independent specialists, diagnosed with primary myelofibrosis (PMF) or transformation to secondary myelofibrosis (post-PV or post-TE), confirmed by bone marrow biopsy, and aged ≥ 18 years.	Significant hepatic or renal dysfunction, typically defined as aspartate and alanine aminotransferase levels greater than 2.5 times the upper limit of normal, total bilirubin above 3.0 mg/dL, or serum creatinine above 3.0 mg/dL; hypersensitivity to biguanide, uncontrolled diabetes mellitus, untreated vitamin B12 deficiency, pregnancy, severe psychiatric disorders, and use of anagrelide and/or ruxolitinib in the sixty days prior to screening	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-2v7d2v4	Effectiveness of green tea and hyaluronic acid in post-tooth extraction repair in patients undergoing radiotherapy	Not yet recruiting	Intervention	2025-12-08	<NULL>	<NULL>	8629	Effectiveness of green tea and hyaluronic acid in post-extraction repair in patients undergoing radiotherapy	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-17	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients with head and neck cancer, of both sexes, over 18 years of age, who require tooth extractions in the context of radiotherapy treatment, either prior to its initiation or afterwards, due to oral cavity preparation or dental emergencies. All participants must agree to take part in the study and provide their signature on the Informed Consent Form	Severely debilitated patients, those who do not accept or do not sign the Informed Consent Form, pregnant or breastfeeding women, individuals with metallic artifacts that impair tomographic analysis, and those who present periapical lesions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:58
RBR-786rf7z	Brazilian Red Propolis Gel for Oral Mucositis from Chemotherapy	Not yet recruiting	Intervention	2025-12-05	<NULL>	<NULL>	8621	Clinical and in vitro evaluation of a brazilian red propolis gel in patients with oral mucositis induced by antineoplastic chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Fundação Hospital Estadual do Acre - Fundhacre	<NULL>	<NULL>	<NULL>	Individuals of both sexes, aged 18 to 70 years, who started chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and docetaxel and presented grade 1 or higher mucositis	Patients with mandibular immobilization or mechanical fixation that prevents visualization of the oral cavity; indigenous patients; foreign patients; patients allergic to propolis, pollen, or with allergic predisposition or atopy to components of bee honey; patients with concomitant inflammatory or degenerative oral disease; patients undergoing chronic therapy with steroids or immunosuppressants; unconscious or sedated patients	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-9bqqpc8	Effects of Erbium Laser on Facial Rejuvenation	Data analysis completed	Intervention	2025-12-05	<NULL>	<NULL>	8622	Effect of Er:YAG laser on labial and buccal mucosa	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Odontologia da Universidade de São Paulo (Fousp)	<NULL>	<NULL>	<NULL>	Males and females aged 35 to 70 years; in good general health; willing to adhere to the study protocol; presenting a chief complaint of aesthetic dissatisfaction with their lips; and pronounced nasolabial folds	Previous application of fillers or botulinum toxin in the region at any given moment; the possibility and/or presence of pregnancy; active oncologic treatment; and other conditions that lead to alterations in circulatory and or metabolic systems	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-6yzr9zb	Transcranial Laser in the Treatment of Depression and Related Symptoms	Not yet recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8614	The impact of Transcranial Laser on Depression, associated symptoms, and biochemical markers: a double-blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Individuals aged 18 to 60 years; both sexes; with depression as measured by achieving the minimum scores on the Patient Health Questionnaire-9 (PHQ-9) for mild or moderate depression	Risk of suicidal ideation; severe depression assessed using PHQ-9 scores; individuals with diseases that may be stimulated by light; immunocompromised individuals; cancer patients; individuals with infectious diseases or in a febrile state; epileptic individuals; pregnant and/or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-7z5pw7y	Effects of Physical Exercise with Electrical Stimulation on the health of elderly individuals with kidney Issues	Not yet recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8615	Effects of a Physical Exercise protocol with or without Neuromuscular Electrical Stimulation on Dialysis efficiency and functionality in elderly people with Chronic Kidney Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-13	Universidade Comunitária da Região de Chapecó	<NULL>	<NULL>	<NULL>	Older adults of both sexes, aged between 60 and 75 years, undergoing hemodialysis treatment for at least three months, who present hemodynamic and clinical stability confirmed by the following parameters: resting heart rate between 50 and 100 bpm, respiratory rate between 12 and 25 breaths per minute, oxygen saturation greater than 90%, blood pressure between 90/60 mmHg and 160/90 mmHg, and body temperature between 36°C and 37.8°C; laboratory tests performed within the last 30 days showing a minimum hematocrit of 30%, hemoglobin level above 8 g/dL, and platelet count greater than 50,000/mm³; preserved lower-limb muscle strength assessed using the Medical Research Council (MRC) Muscle Strength Scale, with a minimum score of grade 3 for hip flexors, knee extensors, and ankle dorsiflexors; cognitive function will be assessed using the Mini-Mental State Examination (MMSE).	Participants with a diagnosis of cancer or chronic lung disease; those who present musculoskeletal limitations that compromise the execution of the exercise protocol for cycling and strength training or that pose a risk to participant safety, such as in the case of hemodynamically unstable older adults; individuals with a high degree of frailty assessed by the Frailty Scale, without functional independence, using a cutoff point of 5; participants who miss more than three consecutive or alternating sessions; those who present changes in clinical condition that prevent the performance of the physical exercise protocol will have their data excluded from analysis; dialysis fistulas in the lower limbs; very active older adults, assessed using the Short Physical Activity Index (Short IPAQ), to determine the physical activity level of older adults with chronic kidney disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-9bxs5rf	Randomized split-mouth clinical trial of Home Dental Whitening with 10%, 15%, and 20% Carbamide Peroxide	Recruitment completed	Intervention	2025-12-04	<NULL>	<NULL>	8616	Comparative clinical split-mouth analysis of at-Home Dental Bleaching with 10%, 15%, and 20% Carbamide Peroxide	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-10	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	Absence of carious lesions, absence of defective and/or fractured restorations, absence of periodontal disease or teeth with spontaneous pain; presence of healthy oral soft tissues and good systemic condition; no history of adverse reactions to peroxides; and teeth with a shade of at least A2; any gender will be accepted; participants must be between 18 and 30 years of age	Presence of restorations on the buccal surfaces of central and lateral incisors, canines, and premolars; use of fixed orthodontic appliances or residual resin on the buccal surface after appliance removal; pregnant or breastfeeding women; smokers and individuals with routine alcohol consumption; those who do not agree to sign the informed consent form; those who have previously undergone bleaching treatment; and individuals with teeth presenting tetracycline staining, fluorosis, or non-vital teeth	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-2zbpvx3	Do combined non-invasive stimulation techniques affect the brain behavior of individuals with depressive symptoms? A randomized controlled trial	Recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8617	Does combined non-invasive neuromodulation affect cortical metrics in individuals with depressive symptoms? a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-11	Universidade Federal De Juíz De Fora - UFJF/GV	<NULL>	<NULL>	<NULL>	Participants with mild to moderate depressive disorder, aged between 18 and 45 years, duly diagnosed and identified through self-report.	Individuals with epilepsy, using anticonvulsant medication and/or with sleep deprivation; participants with metallic materials implanted in or near the head (examples, cochlear implant, implanted electrodes/stimulators, aneurysm clips or coils, firearm projectile fragments, jewelry and hair clips); participants with pacemakers or cardiac stents or other active devices where interaction with the electric field may interfere with their functioning; participants with eczema on the head.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3337xv9	Effect of Hippotherapy on biopsychomotor and functional skills in children and adolescents with Autism Spectrum Disorder: a cohort study	Data analysis completed	Observational	2025-12-04	<NULL>	<NULL>	8618	Equine therapy in Brazil: an epidemiological survey and its contributions to Autism Spectrum Disorder.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Campina Grande (UFCG), Centro de Tecnologia e Saúde Rural, Programa de Pós-Graduação em Ciência e Saúde Animal (PPGCSA).	<NULL>	<NULL>	<NULL>	Children and adolescents with a primary diagnosis or clinical history of ASD (Autism Spectrum Disorder); aged between 2 and 18 years; able to understand simple instructions; available to participate in the equine therapy program once a week.	Participation in other research related to horses; prior experience with equine therapy; presence of other neurological, psychiatric, or genetic diagnoses, such as comorbidities or disorders secondary to ASD (Down syndrome with ASD, bipolar disorder or schizophrenia associated with ASD and/or cerebral palsy with clinical signs of ASD); and lack of authorization from the medical or multidisciplinary team to perform equine therapy.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-6p3g8m3	CRONOEX: how the time of day when physical exercise is performed influences brain function and blood glucose control in people with type 2 Diabetes	Recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8619	CRONOEX: impact of exercise and physical training timing on cognitive, neurofunctional, and circadian responses in type 2 Diabetes: from molecular mechanisms to clinical management	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Both genders; medical diagnosis of type 2 Diabetes (minimum 5 years); age 55-75 years; not participating in regular physical exercise programs; not being a smoker; absence of complications caused by the disease such as retinopathy, coronary artery disease, autonomic neuropathy or uncontrolled systemic arterial hypertension; (viii) obtaining a score &gt; 19 and &lt; 27 on the Montreal Cognitive Assessment.	Failure to participate in one of the assessment procedures; any orthopedic injury or other condition that makes it impossible to carry out the exercise sessions proposed in the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-2pd933q	Effect of Transcranial Magnetic Stimulation (TMS) associated with speech-language pathology treatment in patients with difficulty swallowing after a stroke	Not yet recruiting	Intervention	2025-12-04	<NULL>	<NULL>	8620	Non-invasive brain stimulation in neurological conditions	<NULL>	n/a, n/a, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-10	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Stroke less than 3 months ago; both genders; Rankin scale less than 04; presence of oral communication and/or swallowing disorders; diagnosis of some neurological condition; age over 18 years	Require respiratory support; having magnetic material in the skull or a cardiac pacemaker; epilepsy or a history of seizures	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-42nwshv	Auditory skills in schoolchildren and their impact on learning	Data analysis completed	Intervention	2025-12-03	<NULL>	<NULL>	8611	Effects of Neuroauditory Stimulation (SENA), Visuomotor Stimulation, and Acoustically Controlled Auditory Training on Central Auditory and Visual Processing in schoolchildren	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2018-03-03	Universidade Federal de São Paulo, UNIFESP	<NULL>	<NULL>	<NULL>	Present the signed informed consent and assent forms; Be between 8 years and 11 years and 11 months of age, male or female; Report complaints of learning difficulties; Have hearing thresholds up to 15 dB HL; Show alterations in Auditory Processing and visual perception assessments	Evidence of neuropsychiatric conditions that prevent the performance of the selected procedures; Lack of availability to attend the intervention sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-44tvxzn	Evaluation of simulation-based training effectiveness in postpartum infection treatment	Not yet recruiting	Intervention	2025-12-03	<NULL>	<NULL>	8612	Evaluation of simulation-based training effectiveness in Puerperal Sepsis management: a randomized controlled trial with medical students	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Medical students enrolled in a mandatory obstetrics rotation; with agreement to participate in the study and signature of the Informed Consent Form	Previous participation in sepsis training within the last 6 months; inability to participate in scheduled assessments; withdrawal from the rotation during the study period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-2khq5gc	Detailed analysis of the cellular composition of the Cell-Rich Fraction of fat tissue harvested using Traditional or Focused Light Beam-Assisted Suction	Recruiting	Intervention	2025-12-03	<NULL>	<NULL>	8613	Cellular and molecular characterization of the Stromal Vascular Fraction of adipose tissue obtained by Traditional or Laser-assisted liposuction	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-31	Instituto Nacional de Traumatologia e Ortopedia	<NULL>	<NULL>	<NULL>	Adult participants aged between 40 and 75; Both gender; Presenting full range of motion (0 to 120°); Patients with mild to moderate primary osteoarthritis classified by radiographs (anteroposterior projection) using the Kelgren-Lawrence classification less than or equal to III; residents of the city of Rio de Janeiro	Rheumatological disease; systemic inflammatory disease; active neoplasia; heart disease; renal or hepatic failure; grade III obesity (BMI&gt; 40); positive viral diagnosis by serology or antigen (hepatitis B, C and HIV); patients with a history of trauma, infection or previous surgery in the involved joint; patients with alteration in the measurement of the mechanical axis of the lower limbs (varus or valgus greater than 5°; corticosteroid infiltration in the last 6 weeks; patients who used  non-steroidal anti-inflammatory drug (NSAIDs) in the previous two weeks; patients undergoing viscosupplementation in the last year	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-9p8jnf9	Curcumin and women’s health: investigating its effects in women with overweight and polycystic ovary syndrome	Recruitment completed	Intervention	2025-12-02	<NULL>	<NULL>	8608	Effects of curcumin supplementation on metabolic parameters in overweight and obese women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-02	Centro de Saúde Escola da Faculdade de Medicina de Ribeirão Preto - USP	<NULL>	<NULL>	<NULL>	The sample consisted of women diagnosed with polycystic ovary syndrome who met the inclusion criteria which are women aged between 18 and 40 years; women classified as overweight and obesity grade I and II with body mass index greater than or equal to 25 kilograms per square meter and less than or equal to 39.9 kilograms per square meter	Participants were excluded from the study if they reported an allergy to curcumin or its derivatives, or presented with any of the following conditions pregnancy or breastfeeding period; late-onset congenital adrenal hyperplasia; androgen-secreting tumors; thyroid dysfunction; hyperprolactinemia; cushing&apos;s syndrome; ovarian insufficiency; hypothalamic amenorrhea; chronic kidney disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-7hsd9qj	Comparing two types of physical training and conditioning in patients with HIV/AIDS	Recruiting	Intervention	2025-12-02	<NULL>	<NULL>	8609	Efficacy and safety of a functional multimodal interval physical training protocol vs conventional training on physical function in hospitalized sarcopenic patients with HIV/AIDS: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-18	Instituto Nacional de Infectologia Evandro Chagas INI/FIOCRUZ	<NULL>	<NULL>	<NULL>	Age over 18 years; handgrip test with values greater than 27 KgF for men and less than 16 KgF for women and/or; five-repetition sit-to-stand test (STS5) longer than 15 seconds or inability to perform the test; walking speed less than or equal to 0.8 m/s; and two-minute stationary walk test (TM2) showing signs of low exercise tolerance; low exercise tolerance will be defined as subjective perception of effort by BORG scale greater than or equal to 3 and/or signs of respiratory discomfort (nasal flaring, intercostal retraction) and/or drop in peripheral oxygen saturation (SpO2) less than or equal to 90% during the test, according to the guidelines of the American College of Sports Medicine.	Patients over 60 years old; use of supplemental oxygen less than 5 L/min; refusal to undergo assessment tests; hemodynamic and ventilatory instability; states of catabolism: SIRS, sepsis, symptomatic anemia, among others; osteomyoarticular and/or neurological injury; general condition of physical or mental deterioration that prevents patient cooperation; muscle strength grade less than or equal to 2 in any limb evaluated by the Medical Research Council scale	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-7wj2j57	The positive impacts of Physical Activity in water for Postmenopausal women with Hypertension	Recruiting	Intervention	2025-12-02	<NULL>	<NULL>	8610	Effects of Aquatic Training on functional capacity and metabolic responses of Postmenopausal women with Hypertension: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-16	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Women aged between forty five and sixty years will be included in the study;who are in the postmenopausal period for at least one year and no more than six years;diagnosed with arterial hypertension and using medication for blood pressure control;sedentary meaning not regular practitioners of physical exercise for at least three months as identified in the anamnesis;presenting a medical certificate proving fitness for physical exercise;not presenting musculoskeletal problems or cardiovascular complications that prevent participation in the proposed activities of the study	Women with a history of stroke or acute myocardial infarction will be excluded; those diagnosed with diabetes mellitus; smoking participants; and those who develop health complications during the study that may compromise the safety of performing physical exercises	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-5ygs7cq	Physical Exercise for the mind and body: benefits for the elderly with Dementia.	Recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8599	Effect of Exercise on cognition and functional capacity in older adults with Dementia	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de MInas Gerais	<NULL>	<NULL>	<NULL>	Volunteers aged 60 years or older and residing in the community, have a medical diagnosis of dementia (of any subtype, except dementia with Lewy bodies or secondary to Parkinson&apos;s disease) documented in the medical record, mild level of dementia (CDR 1), have a caregiver willing and able to act as an informant for the participant, do not have physical disabilities that prevent the performance of functional tests in the evaluation	volunteers diagnosed with a severe neurological or orthopedic condition or other comorbidities that prevent participation in the intervention (exercises)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3rmx79q	Evaluation of early Methylene Blue in the microcirculation of patients with Generalized Infections: a feasibility  randomized controlled trial	Recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8600	Evaluation of early Methylene Blue in the microhemodynamics of Septic Shock patients: a feasibility  randomized controlled trial	<NULL>	2-3, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Hospital Santa Casa de Curitiba	<NULL>	<NULL>	<NULL>	Patients aged 18 years or older; diagnosis of septic shock (defined as organ dysfunction with a Sequential Organ Failure Assessment (SOFA) score of 2 points or greater, caused by a dysregulated host response to infection and with persistent hypotension requiring vasopressor therapy to maintain mean arterial pressure at 65 mmHg or higher, and serum lactate level exceeding  2 mmol/L despite adequate fluid resuscitation); or sepsis and persistent hemodynamic dysfunction despite adequate fluid resuscitation, requiring escalation of noradrenaline dose to maintain mean arterial pressure ≥65 mmHg, with prolonged capillary refill time; and less than 6 hours from the diagnosis.	Pregnant or breastfeeding patients; patients with any withdrawal or withholding life sustaining treatment status; patients in the immediate postoperative period following cardiac surgery; refractory septic shock, with a high propability of death within 24h; personal or familiar history of glucose-6-phosphate dehydrogenase deficiency; allergy to methylene blue, phenothiazines or food dyes; recent linezolid administration (within 14 days); recent intake of psychiatric medications with serotonergic activity (within 2 weeks, with the exception of fluoxetine requiring a 5-week washout period), including but not limited to paroxetine, fluoxetine, sertraline, citalopram, escitalopram, venlafaxine, desvenlafaxine, duloxetine, amitriptyline, imipramine, nortriptyline, trazodone, bupropion, buspirone, and mirtazapine; and recent use of monoamine oxidase inhibitors (MAOIs) such as rasagiline and selegiline within 2 weeks of enrollment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:15
RBR-85tmk64	Effect of homeopathic medicines for the treatment of Smoking	Data analysis completed	Intervention	2025-12-01	<NULL>	<NULL>	8601	Effect of Hetero-isotherapics for the treatment of Smoking	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2017-07-26	Faculdade de Farmácia da Universidade Federal do Rio de Janeiro	<NULL>	<NULL>	<NULL>	Smoking participants; at least 18 years old; both sexes; who wish to give up the habit of smoking; participant must be a current smoker, which is someone who smokes daily or occasionally	Not be a smoker. Just be a passive smoker. Be an ex-smoker. Be under 18 years old. Participants who are included in the research, but refuse to adequately respond to the Follow-up questionnaire or do not attend monthly evaluation meetings with the team. People who have not smoked for at least 1 month (ex-smokers) or who do not smoke or who are passive smokers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-10mtfw53	Effect of Ozone Therapy in the adjunctive treatment of Periodontitis: randomized, double-blind, split-mouth clinical trial	Recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8602	Ozone Therapy as an adjunct treatment for Periodontitis	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-15	Centro de Ciências Biológicas e da Saúde - CCBS - Universidade Estadual do Oeste do Paraná - UNIOESTE	<NULL>	<NULL>	<NULL>	Age between 25 and 65 years. Both sexes. Presence of at least 12 teeth in the oral cavity, with at least 3 elements per hemiarch (excluding third molars). Diagnosis of Stage II or III Grade A periodontitis (bilateral periodontal pockets with Clinical Attachment Level (CAL) greater than or equal to 5mm)	Completely edentulous individuals. Pregnant and breastfeeding women. Regular use (for 14 days or more) of antibiotics, anti-inflammatories, and immunosuppressants. Wearing fixed orthodontic appliances. Smokers. Presence of systemic alterations. Undergoing treatment for neoplasms	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3rt39sj	Evaluation of Corticosteroid use in Carpal Tunnel Syndrome Surgery	Recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8603	Comparison of carpal tunnel Decompression with and without Corticosteroid: a randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Empresa Brasileira de Serviços Hospitalares - EBSERH	<NULL>	<NULL>	<NULL>	Adult patients - over 18 years of age; of both sexes; diagnosed with Carpal Tunnel Syndrome (CTS) and requiring surgery; recruited from the surgical referral system of Rio Grande do Norte.	Patients with skin lesions at the surgical site. Users of long-term systemic corticosteroids. Patients with decompensated psychiatric disorders. Patients with decompensated diabetes mellitus.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-4zg9nwh	Comparison of three surgical approaches for removal of the right kidney for donation	Not yet recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8604	Open, laparoscopic, and robotic right donor nephrectomy: a prospective randomized study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Hospital das Clínicas da Faculdade de Medicina da USP - HC FMUSP	<NULL>	<NULL>	<NULL>	Patients aged &gt;18 years. Voluntary living kidney donors approved for transplantation by the institutional medical, ethical, and legal committees	Contraindications to laparoscopic or robotic approaches. Uncontrolled comorbidities. Refusal to provide informed consent. Left kidney donors	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-8q6kj3n	Effects of brain electrical stimulation combined with speech therapy on the voice and speech of individuals with Parkinson’s disease	Not yet recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8605	Effects of tDCS combined with speech therapy on the voice and speech of individuals with Parkinson’s disease: a randomized clinical trial with follow-up.	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Departamento de Fonoaudiologia	<NULL>	<NULL>	<NULL>	Individuals with a medical diagnosis of Parkinson’s disease, at stages I to IV on the Hoehn &amp; Yahr scale, aged over 18 years, of both sexes; being in the “on” medication state during the collection of voice samples; presenting some self-reported or clinically detected communication complaint related to speech and/or voice, as identified by the evaluator during the initial contact	Individuals with severe cognitive or motor impairments that prevent comprehension and/or proper execution of the proposed exercises; pregnant women; individuals reporting other neurological or psychiatric disorders; history of seizures/epileptic crises; previous laryngeal surgery; or history of head and neck surgery (such as deep brain stimulation). Participants who miss more than one session or experience any serious adverse event will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-5c8chm9	Use of Absorbable Synthetic Membrane in bone regeneration with primary or secondary Closure: a non-inferiority clinical ctudy	Not yet recruiting	Intervention	2025-12-01	<NULL>	<NULL>	8606	Comparative evaluation of Absorbable Synthetic Membrane in bone regeneration after third molar extraction: randomized clinical study with split mouth design	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Individuals of both sexes aged; between 18 and 40 years old who are in good general health and have bilateral lower third molars with similar positions in the hemi-arches according to the Pell and Gregory classification	Patients who are pregnant or breastfeeding; smokers; patients taking medication that poses a risk for MRONJ; individuals who show signs of infection at the time of the procedure; individuals with a history of pericoronitis in the 7 days prior to the procedure; individuals with decompensated systemic disease; individuals with a previous diagnosis of bone disease; and individuals who have undergone previous radiotherapy or chemotherapy will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-5jf2whs	Clinical study evaluating the efficacy and safety of Platelet-Rich Plasma combined with topical Minoxidil compared with placebo also combined with topical Minoxidil in men with Androgenetic Alopecia	Recruitment completed	Intervention	2025-12-01	<NULL>	<NULL>	8607	A randomized placebo controlled, double-blind, half-head study to assess the efficacy and safety of Platelet-Rich Plasma on the treatment of Androgenetic Alopecia	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-10	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Participants aged 18 to 65 years. Male gender. With Androgenetic Alopecia (AGA). Normal serum levels of Thyroid-Stimulating Hormone (TSH), Free Thyroxine (Free T4), Iron, Ferritin, Transferrin Saturation, and Complete Blood Count to rule out telogen effluvium. Agreement with the study conditions. Ability to understand and strictly follow the given instructions. Availability to attend periodic follow-up evaluations. Signing of the Informed Consent Form (ICF) and the Photography Authorization Form	Use of topical Minoxidil; oral Minoxidil, or oral Finasteride in the last three months. Performance of any cosmetic procedures on the scalp in the last six months (e.g., microneedling, intradermal drug infusion). Hematologic coagulation disorders, anticoagulant therapy, use of antiplatelet agents, thyroid deficiency, dermatologic disorders, or systemic diseases that contribute to hair loss. Unrealistic expectations. Severe systemic diseases or use of systemic corticosteroids or immunosuppressants. Scalp diseases presenting the Koebner phenomenon. Allergy to tattoo dye. Allergy to Lidocaine	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3tb25z8	Comparison of two bone reconstruction techniques in dental implant treatment: Barbell and Titanium-Reinforced Polytetrafluoroethylene Membranes	Not yet recruiting	Intervention	2025-11-29	<NULL>	<NULL>	8598	Barbell Technique versus Titanium-Reinforced PTFE Membranes in Guided Bone Regeneration: a prospective randomized clinical study	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Instituto de Ciência e Tecnologia - Campus de São José dos Campos - Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Loss of three adjacent teeth in an atrophic alveolar ridge in the maxilla or mandible, according to the horizontal alveolar changes classification; need for bidirectional horizontal bone augmentation; residual bone height (minimum of 8 mm) at the surgical site; adequate oral hygiene; presence of 2 mm of keratinized tissue in the attached gingiva; aged between 18 and 75 years; both genders	Periodontal or peri-implant diseases; contraindications to surgical procedures; dental implants adjacent to the surgical site; smokers; diabetic patients; history of previous radiotherapy or chemotherapy; use of immunosuppressants, bisphosphonates, or corticosteroid therapy; pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:57
RBR-3f6xgk7	Positive pressure during hemodialysis and its impact on the lungs and circulation: a clinical study	Recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8589	Effects of Positive Pressure during the intradialytic period on Pulmonary Congestion and hemodynamic parameters: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-20	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Adults aged equal to or greater than eighteen years, of both sexes, with a diagnosis of Chronic Kidney Disease undergoing regular hemodialysis treatment for at least three months; with dialysis sessions lasting two to four hours, three times per week, in a hospital-based hemodialysis center; clinically stable; without recent infections or decompensations; and able to understand and sign the Informed Consent Form	Patients with absolute contraindication to the use of positive pressure; those with cognitive and or physical impairments that prevent the performance of the tests and assessments proposed in the protocol; those with congestive heart failure classified as class three or four according to the New York Heart Association; with chronic atrial fibrillation; participants of daily hemodialysis programs; pregnant women and or individuals with cardiac pacemakers; and patients unable to tolerate the use of a facial mask and positive pressure due to claustrophobia, anxiety, or respiratory discomfort will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-3b2cggn	Social skills training with RPG for autistic adults: a clinical trial	Not yet recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8590	Role-playing game–based social skills training for adults with autism spectrum disorder: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal do Rio Grande do Sul	<NULL>	<NULL>	<NULL>	individuals of both gender between 18 full years and 35 years of age not yet completed with a prior clinical diagnosis of autism spectrum disorder, according to the criteria of the diagnostic and statistical manual of mental disorders, fifth edition; and who score 60 points or higher on the self-report version of the social responsiveness scale, second edition	illiterate individuals; having intellectual disability with a total intelligence quotient score less than or equal to seventy points assessed through the wechsler abbreviated intelligence scale; having any of the following current mental conditions identified by the structured clinical interview for the disorders of the diagnostic and statistical manual of mental disorders, fifth edition: current manic episode, current hypomanic episode, psychotic symptoms, psychotic disorders, substance use disorders, or risk of suicide; having a moderate or severe depressive episode according to the hamilton depression scale of seventeen items with a score greater than or equal to eighteen points, or moderate or severe anxiety according to the hamilton anxiety scale of fourteen items with a score greater than or equal to eighteen points; participating in another psychotherapeutic intervention during the course of the study or, if receiving a psychopharmacological intervention, having any change in dose or medication within the three months prior to or during the course of the study; attending less than seventy-five percent of the intervention sessions or of the control sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-84v7b82	Knee ligament reconstruction using an ankle graft.	Recruitment completed	Observational	2025-11-28	<NULL>	<NULL>	8591	Anterior cruciate ligament reconstruction associated with medial reinforcement using a graft from the peroneus longus tendon and hamstrings.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-01-01	Irmandade da Santa Casa de Misericórdia de São Paulo	<NULL>	<NULL>	<NULL>	Volunteers of both sexes; minimum age of 18 years and maximum age of 45 years; undergoing reconstruction of the anterior cruciate ligament and extra-articular reinforcement of the anterior oblique ligament with a graft from the long peroneal tendon	Volunteers with previous surgeries on the operated knee; with chondral lesions grades III or IV of the Outerbridge classification for chondral lesions; with other associated ligament injuries in the same knee; who did not complete the minimum follow-up of 24 months; who suffered new traumatic injuries in the operated knee during the follow-up period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-57mmt3n	evaluation of indicators in dilated and hypertrophic cardiomyopathy by cardiologists, using artificial intelligence	Recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8592	evaluation of phenotypic indicators in dilated and hypertrophic cardiomyopathy by cardiologists, using artificial intelligence	<NULL>	n/a, non-randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-20	Instituto do Coração da Faculdade de Medicina da USP	<NULL>	<NULL>	<NULL>	Cardiologist physicians over 18 years of age, of both gender	Non-cardiologist physicians, echocardiographers, or those who do not consent to participate or do not feel able to perform the protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-2jtk8cn	Effects of Brazil nut supplementation on inflammation and oxidative stress in patients with kidney issues on peritoneal dialysis	Not yet recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8593	Effects of Brazil Nut Supplementation on inflammation and oxidative stress in patients with Chronic Kidney Disease undergoing Peritoneal Dialysis	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-02	Hospital Universitário Pedro Ernesto	<NULL>	<NULL>	<NULL>	patients with chronic kidney disease undergoing peritoneal dialysis for at least three months; both sexes; age over eighteen years; regular nutritional follow up at the peritoneal dialysis outpatient clinic of pedro ernesto university hospital; conducted every two months	smokers; pregnant women; lactating women; use of antiinflammatory drugs; individuals who are allergic, intolerant, or have a habitual intake of brazil nuts; infectious diseases, liver diseases, aids, and cancer; use of antioxidant supplements	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-7mwcqzm	Analysis of the correlation between lip thickness and Herpes Labialis lesions: a study in humans to evaluate the efficacy of an Ointment as a treatment	Recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8594	Analysis of the correlation between lip thickness and Herpes Simplex 1 lesions: in vivo, open-label, prospective, single-arm study on the efficacy of a Semi-Solid Formulation as a therapeutic intervention	<NULL>	2, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-16	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Participants aged 14 and older, provided they are accompanied and authorized by a legal guardian, or are over 18 years of age; male and female; individuals with any health condition, with no restrictions related to medical history (except allergies to components of the therapeutic intervention formula); p resenting prodromal signs and symptoms and contacting the researchers within the first 48 hours; availability and interest in adhering to the research protocol; previous clinical history of at least one episode of herpes lesion(s); absence of use of antivirals (systemic and topical) in the 15 days preceding the clinical phase of the study; absence of use of topical products (makeup, moisturizers, creams, and sunscreens) near and on the site of herpes lesions during the clinical phase; internet access (either via cell phone or computer) to complete the research questionnaires.	Participation in a different clinical study related to the treatment of cold sores and involving the use of antiviral and analgesic drugs (limited adherence to the study protocol); use of analgesics and anti-inflammatories in the prodromal phase; allergy to components of the therapeutic intervention formula and to local anesthetics (prilocaine and lidocaine); dry desquamation stage (hard crust); planned use of additional medications for cold sores during the study period; fever above 38°C during the clinical phase of the study; pregnant or lactating women; individuals who have undergone lip filler procedures (with any drug) in the last 12 months prior to the clinical phase of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-6ysxd3v	Effects of orange juice intake on the intestinal microbiota in breast cancer patients undergoing chemotherapy	Recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8595	Longitudinal, prospective, and randomized study on the effects of acute orange juice intake on the gut microbiota in breast cancer patients treated with doxorubicin and cyclophosphamide	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-28	Departamento de Clínica Média - Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Women; over 18 years old; under follow-up at the Oncology service of the Hospital das Clínicas de Botucatu; diagnosed with any type of breast cancer; will receive treatment with doxorubicin in combination with cyclophosphamide.	Gastrointestinal tract disease prior to the cancer diagnosis; use of antibiotic therapy or medications that interfere with intestinal function (such as laxatives, intestinal motility inhibitors or stimulants, or pre/probiotics); constipation; diarrheia; vegetarians; vegans.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-76yd7ph	Effect of high intensity interval training on 24-Hour Central Pressure	Not yet recruiting	Intervention	2025-11-28	<NULL>	<NULL>	8596	Effects of different types of physical exercise on blood pressure, arterial pressure, and indicators of sarcopenia in hypertensive adults and elderly individuals	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-06	Centro de Ciências da Saúde da Universidade Estadual de Maringá	<NULL>	<NULL>	<NULL>	Age between 40 and 79 years; clinical diagnosis of stage I or stage II systemic arterial hypertension confirmed by ambulatory blood pressure monitoring performed within the last six months; regular use of antihypertensive medication; physical and cognitive ability to perform the exercise protocols; signed informed consent form	Inability or refusal to sign the informed consent form; myocardial infarction; revascularization procedures; deep vein thrombosis; stroke or pulmonary embolism in the last twelve months; chronic heart failure class III or class IV according to the new york heart association classification (nyha); unstable arrhythmia; chronic obstructive pulmonary disease requiring corticosteroid therapy or oxygen therapy; renal disease under dialysis treatment; progressive neurological disorders such as parkinson disease or multiple sclerosis; cancer under treatment in the last two years; participation lower than seventy five percent of exercise sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-4wd7srr	Testing Schistosomiasis Diagnostics: What Really Works?	Recruiting	Observational	2025-11-28	<NULL>	<NULL>	8597	Diagnosis of Schistosomiasis - validation and evaluation of tests	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-20	Instituto René Rachou	<NULL>	<NULL>	<NULL>	living in an endemic area for schistosomiasis; over 7 years of age; both sexes; with or without S mansoni eggs in their feces determined by reading 18 slides of a stool sample using the Kato-Katz method	Participants screened as negative to Schistosoma mansoni infection who test positive for the presence of S mansoni eggs in a new stool sample collected after enrollment; Participants screened as having an active infection who report having received treatment with praziquantel between screening and study enrollment; Lactating;  pregnant participants; individuals with impaired cognitive function;  those unable to understand the study; Those who fail to provide one of the required biological samples	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:08
RBR-5j7dqtq	Evaluation of the effectiveness of daily-use toothpastes on gingival health	Not yet recruiting	Intervention	2025-11-27	<NULL>	<NULL>	8583	Evaluation of the effectiveness of commercially available toothpaste on periodontal health - Study protocol for a randomized, controlled, blinded clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Volunteers in good general health; aged between 18 and 30 years; absence of motor, comprehension, or cognitive difficulties that could impair oral hygiene	Volunteers with active dental caries with a cavity exposing the dentin on the teeth used for the simplified oral hygiene index; teeth with developmental defects or dental crowding; periodontal disease with tooth mobility greater than 2mmor periodontal pocket depth greater than 5mm; parafunctional habits such as bruxism or nail-biting, presence of active clasps for removable partial dentures or use of orthodontic appliances; use of antibiotics in the last six months; performance of non-surgical periodontal therapy in the last six months; systemic conditions that may interfere with disease progression or treatment response, such as diabetes or immunological disorders; need for antibiotic prophylaxis for routine dental procedures; prolonged use of anti-inflammatory drugs; smoking; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-6p9769y	Effects of cancer treatment on oral health and ways to manage them	Not yet recruiting	Intervention	2025-11-27	<NULL>	<NULL>	8584	Impact of oncological treatment on oral health: side effects and therapeutic alternatives	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-20	Faculdade de Odontologia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Patients over 18 years of age, of both sexes, with a diagnosis of head and neck cancer who will begin oncologic treatment. Participants must agree to use the alternative mouth rinse containing green tea and hyaluronic acid from the New Care line. They must also authorize clinical evaluations and weekly follow-ups during treatment and in the post-radiotherapy period. All participants will be required to read, understand, and sign the Informed Consent Form, confirming their willingness to participate in the study and allowing the collection and analysis of clinical data	Patients who have a history of allergy or hypersensitivity to any component of the alternative mouthwash (green tea, hyaluronic acid, and other ingredients of the New Care line); who do not agree to participate in clinical evaluations; who do not agree to provide their personal information; who do not accept the conditions of the Informed Consent Form; or who are severely debilitated and not fit to undergo evaluations and follow-up after the end of radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-42t9xmy	Effect of an Abdominal Strengthening Exercise Protocol in university students with Chronic Non-Specific Low Back Pain: A randomized clinical trial	Not yet recruiting	Intervention	2025-11-27	<NULL>	<NULL>	8585	Development and validation of a CORE Stabilization Exercise Protocol in university students with Chronic Non-Specific Low Back Pain: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal de Alfenas- UNIFAL-MG	<NULL>	<NULL>	<NULL>	The criteria will be men and women aged between 18 and 60 years; who have low back pain with or without back stiffness for more than 3 months; self-reported pain at a score of 3 or more on the Visual Numerical Scale (VNS); willing to participate and be randomly allocated to the study groups; availability of time to carry out the intervention in the space provided by the Faculty of São Lourenço	Exclusion criteria include fractures or surgery of the spine or lumbar region; history of spinal cord trauma; tuberculosis; cancer; pregnancy, breastfeeding, or planning a pregnancy during the study period; rejection, fear, or unavailability of the proposed interventions; having undergone any therapy or other spinal treatment in the last three months prior to the study; receiving physical therapy concomitantly with the proposed intervention; patients with psychiatric conditions accompanied by difficulty understanding; severe systemic disease; inability to complete research questionnaires; and ongoing use of medications such as corticosteroids, muscle relaxants, or analgesics	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-7j4tgc6	Study on the effects of sedation with Midazolam and Nitrous Oxide in Hypertensive patients during the placement of Dental Implants	Recruitment completed	Intervention	2025-11-27	<NULL>	<NULL>	8586	The impact of sedation with midazolam and nitrous oxide versus placebo and nitrous oxide in ASA II hypertensive patients undergoing dental implant placement: a randomized, double-blind, split-mouth clinical trial	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-17	Universidade Santo Amaro	<NULL>	<NULL>	<NULL>	Patients aged between 25 and 80 years; controlled hypertensive patients classified as American Society of Anesthesiologists – ASA II; patients with moderate to severe dental anxiety according to the Modified Dental Anxiety Scale (Modified Dental Anxiety Scale – MDAS); individuals indicated for rehabilitation with bilateral single-unit dental implants in the posterior mandibular region; patients of both genders	Chronic Obstructive Pulmonary Disease (COPD); patients classified as American Society of Anesthesiologists – ASA III; regular use of benzodiazepines; allergy or contraindication to any of the study medications; patients with uncontrolled cardiovascular diseases, severe renal insufficiency or severe hepatic insufficiency; patients using bisphosphonates; patients diagnosed with asthma; patients older than 80 years, even if meeting the inclusion criteria; any local or systemic contraindication	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-75g56jn	Home-based exercise program for individuals post-Covid-19	Recruiting	Intervention	2025-11-27	<NULL>	<NULL>	8587	Telerehabilitation for individuals post-Covid-19	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-01	Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul - FAPERGS	<NULL>	<NULL>	<NULL>	Individuals who had COVID-19; present persistent fatigue symptoms; if hospitalized, they must have been discharged more than four weeks ago; aged over 18 and up to 59 years; of both sexes; clinically stable; able to use a computer or smartphone, or have someone to assist them; and have access to a smartphone or computer with an internet connection	Individuals with severe cognitive impairments; individuals with uncorrectable vision problems (even with glasses); with uncorrectable hearing impairments (even with hearing aids); immobility or inability to walk (due to trauma or conditions requiring bed rest); those using assistive walking devices; with diagnosed severe pulmonary hypertension; pre-Covid pulmonary or neuromuscular disease; hemodynamic instability; fever; unstable angina; uncontrolled seizure disorders; postural hypotension; balance problems (score of zero for standing position and feet-together stance on the Short Physical Performance Battery); individuals currently undergoing physical training; those using CPAP (continuous positive airway pressure) for sleep apnea treatment; those with untreated laryngeal or thyroid disease; who have undergone respiratory or head and neck surgery; who currently or previously worked as voice professionals or have been intubated; those with unstable heart disease; diagnosed fibromyalgia; or spirometry-confirmed obstructive ventilatory disorder	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-7knywkd	Association between periodontal problems and metabolic conditions – Cross-sectional study	Recruiting	Observational	2025-11-27	<NULL>	<NULL>	8588	Evaluation of the Relationship between Periodontitis and Systemic Metabolic Alterations – A Cross-Sectional Study.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-10	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Volunteers of both genders; presence of at least 15 natural teeth excluding third molars and teeth with indication for extraction; diagnosis of generalized periodontitis stage III grade A or B; 30% of teeth with probing depth and clinical attachment level greater than or equal to 5mm	long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and/or use of antimicrobials in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; chronic gastrointestinal diseases; extensive prosthetic rehabilitations; tobacco use currently or in the last 5 years; pregnancy and lactation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-8f29rn7	Effects of Electroacupuncture in People with Fibromyalgia	Recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8577	Sleep, voice, and cardiorespiratory function alterations in individuals with Fibromyalgia and the effects of Electroacupuncture	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Volunteers diagnosed with fibromyalgia, characterized by pain upon palpation in at least 11 of the 18 specific tender points for more than three months, on one or both sides of the body, above and below the waist;	Having pituitary tumors or adrenal hyperplasia; epilepsy; diabetes mellitus; cardiovascular diseases; renal failure; drug or alcohol dependence; being pregnant or breastfeeding; use of a pacemaker; having undergone acupuncture sessions to treat insomnia within the past 30 days; untreated laryngeal or thyroid disease; history of respiratory, head, or neck surgery; presence of hearing complaints; self-reported smoking or alcohol consumption; being a voice professional; neurological disease; or pulmonary disease confirmed by spirometry demonstrating an obstructive ventilatory disorder; communication impairments or cognitive deficits	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-6rbk6yg	Working memory during Judo practice	Recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8578	Working memory behavior during Judo practice	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Judo athletes with at least five years of continuous practive	Age under 18, osteomuscular injuries that limit judo practice	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:07
RBR-1082sd5r	Acute effects of breaking sedentary behavior with isometric squat on blood pressure, cardiac autonomic modulation, and cognitive function in hypertensive individuals during the workday	Recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8579	Acute effects of breaking sedentary behavior with isometric squatting on blood pressure, cardiac autonomic modulation, and cognitive function in hypertensive individuals during the workday: a randomized crossover trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-28	Universidade Federal Rural de Pernambuco	<NULL>	<NULL>	<NULL>	Adults with hypertension; aged 30 to 59 years; perform administrative work while seated for more than 6 hours per day; no musculoskeletal problems in the lower limbs that prevent squatting or standing; no cardiac or cerebrovascular diseases; not using insulin; perform occupational activities in a workplace with adequate physical infrastructure; wear flat shoes suitable for performing the interventions	Individuals who do not complete the protocol of the break or control sessions; transferred to another position or function that changes the characteristics of the occupational activity; choose not to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-5mfxbkj	Evaluation of Oral Mucositis in Laser Treatment	Recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8580	Evaluation of Oral Mucositis in Treatment with Photobiomodulation	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-20	Complexo do Hospital das Clínicas da Universidade Federal do Paraná (UFPR)	<NULL>	<NULL>	<NULL>	Volunteer patients aged 5 years or older; of both sexes; regardless of weight, height, race, or social condition; who will begin the Hematopoietic Stem Cell Transplantation (HSCT) protocol due to onco-hematological or hematological diseases.	Patients undergoing autologous transplantation who are under 5 years of age; who use photosensitive medications (tetracycline, sulfonamide, retinoic and glycolic acid); as well as patients who present with elevated core temperature (fever); allergies or any alteration in the skin of the face during treatment.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-65frmbm	&quot;Effects of Brain Stimulation as Therapeutic Support in Body Control Issues in Individuals with Brain Differences: a Randomized Study&quot;	Not yet recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8581	Effects of using Transcranial Direct Current Stimulation as a therapeutic support tool in Autonomic Dysfunction in Neurodivergent individuals: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-30	Instituto Federal de Educação, Ciência e Tecnologia de Pernambuco	<NULL>	<NULL>	<NULL>	Patients treated at the neuromodulation clinic located at the IFPE Campus Pesqueira, referred by the Association of People with Special Rights (PODE), the Psychosocial Care Center (CAPS), and the Basic Health Unit (UBS), all located in the city of Pesqueira-PE, with neurological reports indicating autism spectrum disorder, attention deficit hyperactivity disorder, and other neurodivergences.	Participants with epilepsy, those using anticonvulsant medications and/or suffering from sleep deprivation, patients with metallic implants in or near the head (e.g. cochlear implant, implanted electrodes/stimulators, aneurysm clips or coils, projectile fragments, jewelry, and hair clips), patients with cardiac pacemakers, stents, or other active devices whose interaction with the electric field may interfere with their functioning, patients with eczema on the head, patients with inconclusive diagnostic outcomes, therapy abandonment, and hospitalization	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-7j8fby5	The effect of Beta-hydroxy-beta-methylbutyrate supplementation on muscle mass and tumor progression in Esophageal Cancer patients undergoing Chemoradiotherapy	Not yet recruiting	Intervention	2025-11-26	<NULL>	<NULL>	8582	Use of ß-Hydroxy ß-Methylbutyrate (HMB) as a supplement in the maintenance of muscle mass and Tumor progression in patients with Esophageal Cancer undergoing Chemoradiotherapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	<NULL>	<NULL>	<NULL>	Adult patients - 18 years of age or older; of both sexes; with a confirmed diagnosis of stage III or IV esophageal cancer, without metastases; who are undergoing concomitant chemoradiotherapy; exclusively using enteral nutrition; participants must have adequate physical and cognitive conditions to perform the proposed tests; and agree to participate voluntarily in the study by signing the Informed Consent Form	Individuals with distant metastases; senility or any condition that causes an inability to understand the procedures; inability to adhere to the protocol or refusal of treatment; history of previous thoracic radiotherapy; presence of active collagenosis; clinical conditions that prevent safe participation in assessments; use of parenteral nutrition or exclusively oral feeding; as well as concomitant participation in other clinical trials that may interfere with the results	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:56
RBR-8d4r7gv	Study 1 - Therapeutic and Ergogenic effects of the Regional Herb Tereré on exercise tolerance in well-trained female runners	Not yet recruiting	Intervention	2025-11-25	<NULL>	<NULL>	8566	Therapeutic and Ergogenic effects of a Regional Extract: TERERÉ	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Universidade Federal de Mato Grosso do Sul	<NULL>	<NULL>	<NULL>	Well-trained competitive or recreational female runners; experienced in endurance; healthy; aged 16 years or older; active in the modality for at least 3 years; engaged in regular endurance training (at least 4 times per week); and with familiarity in road races of at least 10,000 m	Presenting injuries during the study period; experiencing adverse effects from caffeine consumption; reporting cardiovascular diseases or chronic non-communicable diseases (NCDs) and any other health conditions; use of medications for cardiac, pulmonary, thyroid, antihypertensive, endocrinological, or neuromuscular conditions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:23
RBR-8yxdhdv	Influence of Tranexamic Acid on recovery after third molar Surgery: a randomized clinical trial	Terminated	Intervention	2025-11-25	<NULL>	<NULL>	8567	The impact of Tranexamic Acid on the quality of the postoperative period of patients undergoing Third Molars Extraction Surgery: a clinical trial	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-03	Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Patients of both sexes between the ages of 18 and 40. Patients undergoing surgery to protect third molars. Those who agree to participate in the study and sign the informed consent form. Those who do not have autoimmune syndromes or diseases. Patients who do not have previously reported psychiatric or psychological disorders. Patients who do not have heart disease, liver disease, rheumatological, diabetic or chronic kidney problems. Those who do not have underlying diseases that alter the patient&apos;s sensory perceptions. Those who do not have lesions or dermatological pathologies on the face, which may hinder the application of the tests proposed in this study	Those who present any neurosensory alteration in the postoperative period. Patients who will use controlled medication or who, due to drug interaction, have contraindication to the use of any of the therapies proposed in this study. Individuals who develop any postoperative infection at the surgical site. Patients who develop any allergy or adverse effect related to the medications used. Participants who present episodes of vomiting or any discomfort that has not been resolved with protective medication. Participants who, for any reason, voluntarily wish to withdraw from the study. Those who do not comply with or do not attend all stages of the research. Women who, during the study period, become pregnant or are breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:30
RBR-7t6rm86	Control of vertical facial growth in children in mixed dentition	Recruiting	Intervention	2025-11-25	<NULL>	<NULL>	8568	Children in mixed dentition with Angle Cl II malocclusion and hyperdivergent facial pattern: analysis and treatments	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-27	Faculdade de Odontologia da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Age range between 7 and 8 years; both sexes; may or may not present with mild or moderate apnea and/or hypopnea; who are in the mixed dentition phase; with all four upper and lower permanent incisors and first molars erupted; in addition to still having at least the four upper and lower deciduous molars; who present with an increase in the lower third in relation to the middle third of the face; mandibular retrusion and a decrease in the transverse dimensions of the upper arch	Individuals with decayed teeth or teeth requiring extensive treatment or with periodontal disease; those with temporomandibular dysfunction; rheumatoid arthritis; those using medication that interferes with growth; those with severe sleep apnea; or whose general health condition contraindicates orthodontic treatment; those with congenital problems involving the temporomandibular joint (TMJ) and/or the cranial, orofacial, and cervical regions; those who are unavailable to participate in the study or unable to answer the quality of life questionnaires	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:41
RBR-3t9xx6j	Evaluation of the use of red propolis from Alagoas in improving the immunity of HIV patients undergoing treatment	Recruiting	Intervention	2025-11-25	<NULL>	<NULL>	8569	Evaluation of the use of Brazilian red propolis in cd4 count and viral load of HIV patients undergoing antiretroviral treatment: randomized, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-09-02	Centro Universitário Cesmac	<NULL>	<NULL>	<NULL>	Volunteers diagnosed with human immunodeficiency virus (HIV); of both sexes; aged 18 to 59 years; undergoing antiretroviral therapy (ART); with undetectable viral load; and with a CD4 count below 350 cells/mL will be included	Pregnant women; homeless patients; patients allergic to propolis; hospitalized patients; people with mental illnesses that prevent participation in the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:44
RBR-7qb7wq3	Efficacy of knee joint infiltration with BMA - non-inferiority relantionship	Recruitment completed	Intervention	2025-11-25	<NULL>	<NULL>	8570	Relative efficacy of intra-articular infiltrations in the treatment of knee osteoarthritis - randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade de Taubaté	<NULL>	<NULL>	<NULL>	Patients diagnosed with knee arthritis stages II and III of Kellgren and Lawrence (KL); pain according to the visual analogue scale greater than 4 (VAS 2000); between 18 and 65 years old; both genders	Patients with knee arthritis stages I and IV of Kellgren and Lawrence (KL); previous infiltration; previous knee surgery in the last year; use of immunosuppressants; chronic use of corticosteroid therapy; focal chondral lesion; collagen deposition diseases; patients with rheumatological conditions; immunosuppressive pathologies	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:48
RBR-109zgrk9	How intra-workout Caffeine Gel Supplementation impacts cycling performance	Data analysis completed	Intervention	2025-11-24	<NULL>	<NULL>	8571	Effects of intra-workout Gel Caffeine Supplementation on the modulation of the autonomic nervous system autonomic nervous system and intermittent sprint performance in cyclists	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-02	Universidade Federal do Rio de Janeiro (UFRJ)	<NULL>	<NULL>	<NULL>	Male sex; age between 25 and 45 years; at least four years of regular cycling practice; no current use of medications that interact with caffeine; and absence of medical conditions, including cardiovascular, gastrointestinal, musculoskeletal or metabolic disorders in the previous three months	Individuals diagnosed with gastritis; hypertension; allergy to supplement components such as flavorings or sweeteners; use of antidepressants or beta blockers; participants who did not correctly follow the experimental protocol	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:50
RBR-2rkgskw	Use of electrical stimulation on the brain and spinal cord for the treatment of Depression	Recruiting	Intervention	2025-11-24	<NULL>	<NULL>	8572	Brain and spinal cord Neuromodulation in Depression	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-14	Instituto de Ensino e Pesquisa Alberto Santos Dumont	<NULL>	<NULL>	<NULL>	Individuals diagnosed with Major Depressive Disorder (MDD) according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM-5-TR); age between 18 and 65 years; be literate; score of at least 18 points on the Hamilton Depression Rating Scale (HAM-D); agreement to participate in the study, by signing the Informed Consent Form (ICF); clinical stability, with no significant changes in medication treatment in the last 4 weeks; being in stable psychotherapeutic and/or medication follow-up for at least 4 weeks	Diagnosis of severe comorbid psychiatric disorders (Bipolar Disorder, Schizophrenia); history of neuromodulatory interventions (such as Transcranial Direct Current Stimulation (tDCS) or Transcranial Magnetic Stimulation (TMS)) in the last 6 months; current use of illicit drugs or substance abuse; medical conditions that contraindicate the use of electrical stimulation (severe heart disease, epilepsy, etc); pregnant or lactating women; presence of a pacemaker, metal implants, or other electronic devices in the body; not being in stable psychotherapeutic and/or medication follow-up for at least 4 weeks; changing or discontinuing medications during the protocol; presenting a significant suicide risk according to the Suicidal Ideation Questionnaire (SIQ)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:51
RBR-45r4p9c	Ceramic Nanotubes in the Treatment of Anteroinferior Orthodontic Relapse	Recruiting	Intervention	2025-11-24	<NULL>	<NULL>	8573	Clinical application of ceramic nanotubes in the treatment of mandibular anterior orthodontic relapse: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Faculdade de Odontologia de Bauru – Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients aged between 13 and 30 years; presence of mild to moderate mandibular anterior crowding with a Little’s irregularity index greater than 2 mm; satisfactory posterior occlusion showing proper intercuspation of molars and premolars; complete permanent dentition with all teeth present at least up to the first molars; acceptable oral hygiene assessed by clinical examination; good general health	Patients with the presence of any malocclusion requiring orthodontic treatment other than anterior crowding; presence of large rotations or positional alterations of the canines; periodontal conditions that may be aggravated by labial inclination of the lower incisors; poor oral hygiene or presence of active periodontal disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:53
RBR-29fpk5b	Online guidance for school adolescents to better cope with sad thoughts and prevent Depression	Recruiting	Intervention	2025-11-24	<NULL>	<NULL>	8574	Prevention of Depression in school adolescents: exploring the applicability and effectiveness of a Cognitive-behavioral intervention	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Núcleo de Saúde Mental, Cognição e Comportamento, Curso de Psicologia, Universidade Federal de Pelotas	<NULL>	<NULL>	<NULL>	Participants will be included who are enrolled and attending from 6th to 9th grade of elementary school or high school in the participating educational institutions located in the urban area of the municipality of Pelotas; who live in the urban area of the municipality of Pelotas; who do not present, according to self-report or institutional information, any disability that prevents understanding of the instructions and responding to the research instruments; who are not at risk of failing due to absences or an equivalent situation	Participants will be excluded who are outside the target age range of 10 to 19 years; who do not have a device with regular internet access that allows participation in the online activities	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:54
RBR-959mr56	Supplement for patients undergoing treatment for squamous cell carcinoma of head and neck	Not yet recruiting	Intervention	2025-11-24	<NULL>	<NULL>	8575	Dietary Supplement for Patients Undergoing Treatment for Head and Neck Squamous Cell Carcinoma	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-06	Universidade Estadual de Montes Claros	<NULL>	<NULL>	<NULL>	Patients over 20 years of age. Both sexes. Diagnosis and treatment of head and neck cancer in a hospital participating in the study. Participation voluntarily authorized through signing of the Free and Informed Consent Form. Presence on the scheduled days for data collection and nutritional assessment	Patients who discontinue cancer treatment or do not follow the instructions related to the use of the dietary supplement. Patients with allergies or intolerance to any ingredient of the formula. Diabetic patients. Patients using feeding tubes. Oncology patients with neoplasms in anatomical sites other than the head and neck. Patients not identified by the researchers. Patients who refuse to participate or have not signed the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:55
RBR-5pgfy5j	The use of Auriculotherapy in the Treatment of smoking cessation	Recruiting	Intervention	2025-11-24	<NULL>	<NULL>	8576	Use of Auriculotherapy combined with Conventional Treatment in smoking control: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-22	Universidade Federal de Juiz de Fora	<NULL>	<NULL>	<NULL>	Be 18 years of age or older; both genders; Smoker; Be enrolled in the Tobacco Control, Prevention, and Treatment Service (SECOPTT) in the city of Juiz de Fora, Minas Gerais; Express a desire to quit smoking; Be available to participate in the study	Presence of infection, inflammation, or injury to the auricle; Use of piercings or ear gauges (except regular earrings); Allergy to micropore; Pregnancy; Asthma and bronchitis; Cognitive difficulties that prevent data collection through assessment instruments	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:57
RBR-2j5rvrc	How Royal Jelly Can Protect Your Body from Oxidative Damage During Intense Exercise	Recruitment completed	Intervention	2025-11-22	<NULL>	<NULL>	8540	Effect of Royal Jelly supplementation on oxidative stress parameters associated with high-intensity interval training	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal De Uberlândia	<NULL>	<NULL>	<NULL>	Males; aged between 18 and 35 years; practitioners of aerobic physical activity for at least 6 months; no history of chronic diseases; non-smokers; who do not take any type of controlled medication or antioxidant supplementation	People who use antioxidant supplements or controlled medication; who have metabolic or chronic diseases; smokers; allergic to bee products; sedentary; have muscle injuries or infectious and inflammatory conditions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:58
RBR-46gd7h3	Acute effect of high-intensity exercise on arterial stiffness in older adults: a randomized crossover clinical trial.	Not yet recruiting	Intervention	2025-11-21	<NULL>	<NULL>	8541	Acute response of arterial stiffness to anaerobic capacity in elderly individuals: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Older adults of both sexes aged 60 to 79 years, physically able to perform moderate to vigorous intensity physical exercise, and available to participate in the project’s scheduled activitie	The criteria that prevent participation are individuals with debilitating neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, or plegias; those with reduced intellectual capacity; individuals with severe cardiovascular diseases, including heart disease, arrhythmias, or uncontrolled hypertension; persons with medical contraindications to physical exercise, such as recent surgeries, joint prostheses, or musculoskeletal injuries; participants simultaneously enrolled in other clinical studies	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:59
RBR-4x4xj3b	Immediate effect of hypnosis on low back pain	Not yet recruiting	Intervention	2025-11-21	<NULL>	<NULL>	8542	Immediate analgesic effect of a single hypnosis session in individuals with chronic low back pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Participants experiencing chronic nonspecific low back pain; pain and discomfort localized below the costal margin and above the inferior gluteal folds, with or without leg pain; symptom duration of at least 3 months; average pain intensity ≥ 3 on the 0–10 numerical pain rating scale at the time of assessment; able to understand Portuguese through both written and audio materials	Participants with specific spinal pathologies (e.g. tumor, infection, fracture, inflammatory disease); radiculopatia lombar (defined as at least two of the following signs: muscle weakness, altered reflexes, or sensory loss in the distribution of the same spinal nerve); diagnosis of neurological, renal, cardiovascular, psychiatric conditions; pregnancy or postpartum period of less than 3 months; cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:20:15
RBR-103bky8r	Activity of carvacrol and thymol in controlling bacterial accumulation on teeth and gum bleeding	Data analysis completed	Intervention	2025-11-19	<NULL>	<NULL>	8543	Activity of carvacrol combined with thymol in the control of supragingival dental biofilm and gingival bleeding: a longitudinal randomized clinical study	<NULL>	1-2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-12-10	Departamento de Clínica Odontológica	<NULL>	<NULL>	<NULL>	Healthy volunteers; both genders which does not constitute a bias for this study; non-smokers; absence of dental caries; age between 18 and 60 years as they are adults; having 20 or more teeth in the oral cavity; presence of supragingival dental biofilm; presence of bleeding on probing; signing a free and informed consent form	Smoker volunteers; those who have used antibiotics in the last 3 months; those who present clinically detected periodontitis by periodontal probing and radiographic examination (serial imaging); presence of soft tissue lesions in the oral cavity; patients who present sites with &gt;=4mm probing depth; those who present teeth with extensive caries involving at least 10 teeth; holders of orthodontic devices; holders of ceramic or acrylic prostheses at least 10 dental crowns; patients who showed difficulties attending the clinic for periodic evaluations until the end of the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:02
RBR-4bdqq3q	Immediate effect of Low-intensiy LED Light and Manual Therapy applied to the Head on Anxiety, Sleep Quality, and Postural Control in Young Adults a comparative study with randomly assigned groups	Recruiting	Intervention	2025-11-19	<NULL>	<NULL>	8544	Immediate Effect of Transcranial Photobiomodulation and Cranial Manual Therapy on Anxiety, Sleep Quality, and Postural Control in Young Adults a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	CCS - Programa de Pós-Gradruação em Ciências da Reabilitação	<NULL>	<NULL>	<NULL>	Age 18 to 30 years; both sexes; a score above 11 points on the Beck Anxiety Inventory	Participants who do not attend on the previously determined days; those who use medication for the treatment of sleep or anxiety; those with migraines; neoplasms; neurological diseases or rheumatological diseases	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:03
RBR-4cvfgnh	Evaluation of cerebral wave patterns, memory and cortisol levels in musicians with abusive alcohol consumption following a single session of brain stimulation	Recruiting	Intervention	2025-11-19	<NULL>	<NULL>	8545	Evaluation of electroencephalographic parameters, working memory, and cortisol levels in musicians with abusive alcohol consumption following a single session of Transcranial Direct Current Stimulation	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-14	Universidade Federal do Espírito Santo - UFES	<NULL>	<NULL>	<NULL>	Professional male or female musician; between 21 and 59 years old; with a minimum of two years of formal training and/or professional musical practice; who is professionally active (performing live or producing in a studio)	Volunteers must not present absolute pitch; a diagnosis of moderate to severe hearing loss; Addison’s disease; Cushing’s disease. They must not consume any food or dietary supplements that could alter cortisol level; such as vitamin C; whey protein; green tea; glutamine; magnesium; medications like prednisone and dexamethasone	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:04
RBR-5hf2t93	Psychological treatment for people with emotional-related disorders treated at an outpatient clinic in the metropolitan region of Curitiba	Recruiting	Intervention	2025-11-19	<NULL>	<NULL>	8546	Randomized controlled clinical trial of psychotherapeutic interventions for patients with conversion disorders treated at a specialized outpatient clinic in the metropolitan region of Curitiba	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-03	Programa de Pós-graduação em Medicina Interna e Ciências da Saúde	<NULL>	<NULL>	<NULL>	Participants of both sexes; over 18 years of age; diagnosed with Conversion Disorder	Inability to respond to the instruments used during the interview due to any medical condition; absence of typical conversion disorder symptoms for at least 8 weeks prior to the recruitment date; inability to participate in the study due to substance use disorders; refusal to sign the informed consent form; patients already undergoing psychotherapeutic treatment elsewhere, other than the clinic hosting this study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:05
RBR-5wcg6v5	Study of two types of Strength Training on the amounts of two Substances in the blood.	Recruitment completed	Intervention	2025-11-18	<NULL>	<NULL>	8547	Acute effects of strength training sessions at different intensities and fitness levels on plasma concentrations of IRISIN and BDNF in young adults.	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Ouro Preto	<NULL>	<NULL>	<NULL>	To be between 18 and 30 years old; to be male; not to be strength trained; to be strength trained; to have no positive responses on the fitness questionnaire for physical activity; to have no cardiovascular disease risk factors classified as moderate or high risk; to have no recent injuries, pathologies, or health conditions that could be aggravated by the procedures; to not be using substances that could interfere with the experimental procedures; to maintain similar food consumption on the days of the tests and the performance of the training protocols and blood collections	Failure to attend scheduled research phases; failure to follow recommendations the day before the one-repetition maximum test and training protocols; inability to complete the research protocol; impediment to proper blood collection; any health incident during the research	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:07
RBR-7sk3zsn	Impact of Lifestyle Modifications on Optimal Metabolism and Quality of Life in Women Treated for Breast Cancer – The Blue Flower Project	Recruitment completed	Intervention	2025-11-18	<NULL>	<NULL>	8548	Impact of Lifestyle on the Physical and Metabolic Health and Quality of Life of Women Treated for Breast Cancer: The Blue Flower Project	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-01	Departamento de Ginecologia e Obstetrícia	<NULL>	<NULL>	<NULL>	Women, aged between 45 and 75 years, with a histological diagnosis of breast cancer who had undergone sentinel axillary lymph node biopsy or axillary lymphadenectomy; who had completed cancer treatment (chemotherapy and/or radiotherapy), except for hormone therapy; clinical stage I, II, or III; and the ability to understand and consent to participate in the study.	Women with stage IV and/or metastatic disease; alcohol or drug users; clinical lymphedema of the upper limb; athletes; neurological, musculoskeletal, or other conditions limiting participation in a regular physical exercise program; or carriers of a cardiac pacemaker	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:08
RBR-2ynphzg	Assessment of skin irritation after use of a medical device	Not yet recruiting	Intervention	2025-11-18	<NULL>	<NULL>	8549	Orc_147832_25-0732-01_assessment of primary dermal irritability, cumulative dermal irritability and dermal sensitization (hript)	<NULL>	n/a, single-arm-study, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-24	Medcin Pesquisa Clínica Ltda	<NULL>	<NULL>	<NULL>	Participants of both sexes aged 18 to 70 years; phototype: I, II, III and IV, according to the adapted Fitzpatrick scale; intact skin in the application area; agreement to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for application and reading of dressings; understanding, consent and signing of the informed consent form	Pregnancy or risk of pregnancy/lactation; use of anti-inflammatory drugs 30 days prior or immunosuppressive drugs for up to three months before selection; immunosuppression due to active drugs or diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the evaluation or during the study period; anticipated sea bathing, swimming pool or sauna during the study; practice of water sports during the study; dermatographism; use of oral or topical treatment with vitamin A acid or its derivatives up to 1 month before the start of the study; aesthetic or dermatological treatment on the body within 3 weeks before selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization, irritation or photosensitivity to topical products; active skin pathologies that may interfere with the study results; skin reactivity; use of new medications during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; Relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient in the study product; history of non-adherence or unwillingness to adhere to the study protocol; Medcin or sponsoring company employees involved in the study, or a close family member of an employee involved in the study; other conditions considered by the investigator as reasonable grounds for disqualification from study participation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:09
RBR-5cz39kj	Results of non-surgical endodontic treatment in teeth with apical periodontitis after use of intracanal bioceramic medication	Recruiting	Intervention	2025-11-18	<NULL>	<NULL>	8550	Outcomes of nonsurgical Endodontic Treatment in teeth with apical Periodontitis after the use of a Bioceramic intracanal medication: a randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-08	Fundação Universidade de Pernambuco	<NULL>	<NULL>	<NULL>	Single-rooted teeth with a single root canal diagnosed, with necrotic pulp and clinical and radiographic evidence of asymptomatic apical periodontitis in untreated teeth	"Teeth exhibiting cracks or root fractures; teeth with extensive coronal caries destruction that cannot be restored or isolated; patients presenting painful symptoms; painful periapical abscess; periodontal pockets greater than 4 mm in depth; complex anatomies of the root canal system; internal or external root resorption;
Immature teeth; calcified canals; any surgical accident resulting in the inability to achieve foraminal patency; participants unavailable for follow-up visits; participants continuously using nonsteroidal anti-inflammatory drugs or corticosteroids; participants unable to understand and cooperate with study procedures or provide informed consent; participants with a significant systemic disease in their medical history"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:10
RBR-6hdns7j	Vagal auricular stimulation for somatosensory tinnitus in patients with temporomandibular dysfunction	Not yet recruiting	Intervention	2025-11-18	<NULL>	<NULL>	8551	Non-invasive brain stimulation in neurological conditions	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-10	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	<NULL>	<NULL>	<NULL>	Participants aged 18 years or older, of both genders, with temporomandibular dysfunction according to the Diagnostic Criteria, with alterations in heart rate variability in at least 2 of the 3 time points of the orthotest, and with somatosensory tinnitus	Individuals with neurological, cognitive, or linguistic impairments will be excluded from the study; those who do not use the oral language code; those with tonal and vocal audiometry outside the normal limits; individuals with rheumatological diseases such as rheumatoid arthritis and ankylosing spondylitis; those with cardiac arrhythmia or other cardiovascular conditions using beta-blockers; pregnant women or women in the puerperium or postpartum period; patients diagnosed with cancer, epilepsy, skull, cervical or rib fractures, and severe osteoporosis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:11
RBR-339tjg8	The effects of parasacral nerve electrotherapy combined with behavioral changes and bladder retraining on the quality of life of women with overactive bladder: a randomized controlled clinical trial	Not yet recruiting	Intervention	2025-11-18	<NULL>	<NULL>	8552	The effects of adding Transcutaneous Electrical Stimulation of the Parasacral Nerve to Behavioral Therapy and Bladder Training on the Quality of Life of women with Overactive Bladder: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-06-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	<NULL>	<NULL>	<NULL>	Women over 18 years of age, with complaints of overactive bladder with Urgency Urinary Incontinence; who obtain a score greater than or equal to 8 in the Overactive Bladder Validated 8 (OAB-V8) questionnaire, who have had sexual intercourse	Not knowing how to read and not being able to answer the questionnaires; presenting symptoms of urinary tract infection on the day of the assessment; not having undergone corrective surgery for urinary incontinence; not having undergone previous pelvic radiotherapy; having neurological disease; not undergoing pharmacological and physiotherapeutic treatment for overactive bladder; presenting only Stress Urinary Incontinence (SUI), having symptoms of overactive bladder but not losing urine; grade 3 anterior and posterior wall prolapse	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:19
RBR-10kf7dvz	Auriculotherapy to reduce back pain in cleaning workers	Recruitment completed	Intervention	2025-11-17	<NULL>	<NULL>	8553	Auriculotherapy in reducing chronic spinal pain in hospital cleaning service workers: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-09-16	Universidade Federal de Santa Maria	<NULL>	<NULL>	<NULL>	Must be at least 18 years old, of either sex; availability for auriculotherapy sessions; medical diagnosis of chronic pain (minimum duration of three months) or pain in the last year and in the last seven days (according to the assessment of the standardized Nordic questionnaire) in the region of the spine (neck pain, chest pain and/or lower back pain), including the regions between the first cervical vertebra and the gluteal fold; and pain intensity with a corresponding value of at least 4, on the numerical pain scale	Being pregnant; diagnosed with kidney stones with surgical indication; reporting allergy to seeds; having inflammation in the auricle; already undergoing treatment for chronic musculoskeletal pain with alternative therapies; being on new medication in the last 30 days (in order to avoid confusion of interventions)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:13
RBR-2ny7pqt	Effectiveness of comparing virtual reality and therapeutic exercises via videoconference on active behavior, emotional perception and sensation of effort in older persons during the new Coronavirus period	Recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8554	Effect of comparing game to virtual environment and physiotherapy conventional teleservice on physical activity, mood state and perception of exertion in elderly people during Covid-19 pandemic	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-03	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Both sexes; age between 60 and 80 years; in home isolation; internet access with notebook and cell phone; presence of family member or caregiver nearby; no restrictions on movement in the upper limbs	Those who give up participating during the protocol; do not understand the commands necessary to perform the tests in the familiarization phase; are unable to perform the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:14
RBR-967thyx	Combining Brain Stimulation and Reading Therapy to Help People with Dyslexia	Recruitment completed	Intervention	2025-11-17	<NULL>	<NULL>	8555	Association of Transcranial Direct Current Stimulation with Multilevel Reading Therapy for Rehabilitation in Dyslexia: Procedures Protocol and Clinical, Controlled, Randomized, Double-blind Trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-01	Escola Paulista de Medicina - Universidade Federal de São Paulo (UNIFESP)	<NULL>	<NULL>	<NULL>	Children of both sexes; aged 9 to 12 years; with a multidisciplinary diagnosis of Developmental Dyslexia; from outpatient clinics of the Hospital São Paulo, Paulista School of Medicine of the Federal University of São Paulo	Uncorrected auditory sensory deficits; uncorrected visual sensory deficits; epilepsy; metallic implant in the skull or hearing aids	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:15
RBR-6x6vjb9	Perception of Medical Students on Palpation of the Popliteal Pulse	Recruiting	Observational	2025-11-17	<NULL>	<NULL>	8556	Perception of medical students regarding popliteal pulse palpation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-01	Associação Beneficente Bom Samaritano	<NULL>	<NULL>	<NULL>	Be a medical student; be enrolled at Unicesumar	Not being a medical studen	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:16
RBR-6syd77s	Inhalation of chamomile aroma for pain and anxiety during arterial sheath removal after cardiac surgery	Not yet recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8557	Effect of aromatherapy with Matricaria chamomilla essential oil on pain and anxiety in the context of femoral arterial sheath removal: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Rodrigo Assis Neves Dantas Dantas	<NULL>	<NULL>	<NULL>	Inclusion criteria will be based on patients aged 18 years or older; admitted to the Hemodynamics Unit of Heart Hospital of Natal for first-time ACTP-type cardiovascular surgical procedures requiring removal of an arterial introducer via the femoral approach; and undergoing an elective cardiovascular procedure.	Exclusion criteria include patients with chronic pain; continuous use of analgesics, anxiolytics, or antidepressants; neurological and/or cognitive problems that compromise comprehension and use of the scale at the appropriate time; olfactory impairment or respiratory disease; and allergies or sensitivity to chamomile.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:16
RBR-6g7wmqp	Effects of Pre-Load with Hydrolyzed Collagen on Blood Sugar and Health in Patients with Obesity and Diabetes	Not yet recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8558	Acute and Chronic Effects of Hydrolyzed Collagen Pre-load on the Modulation of Glycemia, Hormonal, Inflammatory, and Metabolic Profiles in Patients Living with Obesity and Pre-diabetes or Type 2 Diabetes: A Randomized, Double-Blind Crossover Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal de Lavras	<NULL>	<NULL>	<NULL>	Adults over 18 years of age, able to provide free and informed consent; Diagnosis of Obesity or Overweight and Glycemic Dysregulation: Body Mass Index (BMI) between 25 and 39.9 kg/m² and/or waist circumference &gt; 88 cm for women and &gt; 102 cm for men, and/or Waist-to-Hip Ratio (WHR) &gt; 0.5; Pre-diabetes: Fasting glucose between 100-125 mg/dL OR Glycated Hemoglobin (HbA1c) between 5.7-7.0% OR Oral Glucose Tolerance Test (OGTT) with 2-hour post-load glucose between 140-199 mg/dL, without medication use or only on metformin; Type 2 Diabetes Mellitus (T2DM): Individuals using only stable-dose metformin or lifestyle modifications for glycemic control; Stable weight (fluctuation of ± 3 kg) in the last 3 months before screening	Smokers; Type 1 or Type 2 Diabetes Mellitus using insulin, sulfonylureas, Glucagon-like Peptide-1 agonists, or other antidiabetic medications that could mask the effect of the intervention (except metformin, if included in the inclusion criteria); Glycated Hemoglobin &gt; 8.0%, indicating inadequate glycemic control that would require more intensive pharmacological interventions and could mask the effect of the nutritional intervention; Severe clinical conditions such as chronic kidney disease (stage 3 or higher, estimated glomerular filtration rate &lt; 60 mL/min/1.73m²), significant chronic liver disease (Aspartate Aminotransferase or Alanine Aminotransferase &gt; 3x the upper limit of normal), severe cardiovascular disease (myocardial infarction, stroke in the last 6 months, decompensated heart failure, unstable angina), active inflammatory bowel diseases (Crohn&apos;s Disease, Ulcerative Colitis), autoimmune diseases, except Hashimoto&apos;s, cancer undergoing treatment in the last 5 years; Use of Concomitant Medications: Systemic corticosteroids, medications that significantly affect glucose metabolism or gastrointestinal function (e.g., SGLT2 inhibitors, glitazones, some psychotropics); Collagen supplements, in the 3 months prior to the study; Regular use of laxatives or other supplements (e.g., other high-dose fibers, specific probiotics/prebiotics) that could impact intestinal health or glucose metabolism, and that cannot be discontinued during the study; Antibiotics in the last 3 months before the intervention; Surgical Conditions: History of bariatric surgery or other gastrointestinal surgeries that significantly alter absorption or intestinal transit; Specific Conditions: Pregnancy or breastfeeding, eating disorders (anorexia, bulimia nervosa), alcohol or drug abuse, known allergy or intolerance to any component of the test product or placebo; Inability to Consent: Any physical or mental condition that prevents understanding and providing informed consent	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:18
RBR-578rqds	Clomiphene vs Progesterone in Ovarian Stimulation in Patients with Low Ovarian Response	Recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8559	Clomiphene versus Progesterone in an Ovarian Stimulation Protocol in Patients with Poor Ovarian Response: An Open-Label Randomized Clinical Trial	<NULL>	4, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-21	Hospital de Clínicas de Porto Alegre	<NULL>	<NULL>	<NULL>	Age between 18-45 years; Female gender; Patients undergoing their first PPOS protocol who meet the criteria for POSEIDON group 3 (women &lt;35 years old with low ovarian reserve, AFC&lt;5) or POSEIDON group 4 (women ≥35 years old with low ovarian reserve, AFC&lt;5); Indication for in vitro fertilization or intracytoplasmic sperm injection; Signed informed consent	Chromosomal abnormalities in either partner; Oocyte cryopreservation, oocyte or sperm donation; Endometrioma (≥ 3 cm on imaging); Combined transfer of embryos from different stimulation cycles; Contraindication to the use of progesterone or clomiphene	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:19
RBR-7nz822g	Effect of macadamia nuts and peanuts on the metabolism of women with obesity	Recruitment completed	Intervention	2025-11-17	<NULL>	<NULL>	8560	Consumption of macadamia nut (Macadamia integrifolia) and peanut (Arachis hypogaea L.) and their effects on the metabolism of women with Obesity: a crossover clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2022-12-12	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Women aged between 18 and 45 years; Women with a body mass index between 30.0 kg/m² (kilograms per square meter) and 39.9 kg/m² (kilograms per square meter), classified as having grade 1 and grade 2 obesity	Use of medications for the treatment of hyperlipidemia; with a diagnosis of hypertension, type 2 diabetes, dyslipidemia, and metabolic syndrome (self-reported); presence of diseases and/or history of surgeries that compromise nutrient absorption (self-reported); use of vitamin and/or mineral supplements; use of supplements containing fatty acids; use of supplements containing any amino acids; being pregnant and/or participating in another clinical study; undergoing diet therapy for weight loss; being a smoker and/or consuming alcohol; having a food allergy to nuts or peanuts; regular consumption of nuts or peanuts in the diet (in the last 3 months); intense physical activity	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:20
RBR-2mxrcjw	Comparative effects of Viscosupplementation and Triamcinolone on quality of life in patients with Knee Osteoarthritis	Data analysis completed	Intervention	2025-11-17	<NULL>	<NULL>	8561	Viscosupplementation and Triancinolone: impact on the quality of life of patients with Knee Osteoarthritis	<NULL>	4, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-01	Faculdade Ingá - UNINGÁ	<NULL>	<NULL>	<NULL>	Patients of both sexes aged 45 or older. Diagnosis of symptomatic osteoarthritis (OA) of the knee. Diagnosis confirmed by radiological examination. Must have sought outpatient care between January and March 2023	History of knee surgery or trauma. Use of oral chondroprotectors in the past year. Having received corticosteroid injections in the past year. Having undergone viscosupplementation in the past year	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:21
RBR-6yysksv	Effects of Yoga on the lives of caregivers of children with Autism in Acre	Not yet recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8562	Yoga as an Intervention in the Quality of Life and Emotional States of caregivers of children with Autism Spectrum Disorder in Acre	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal do Acre	<NULL>	<NULL>	<NULL>	Caregivers of any gender; aged 18 years or older; whose children (here considered to be between 2 and 14 years old) are diagnosed with Autism Spectrum Disorder using the classification indicated by ICD-10 with a medical report dated at least six months prior; receiving regular care at the care facility for at least six months; the caregiver must serve as the primary caregiver	Presence of health conditions, both physical and mental, that impair the individual&apos;s ability to complete questionnaires or respond to interviews independently will be considered an exclusion criterion	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:22
RBR-44bz7vj	Mindfulness program for federal public servants in southern Brazil: effects on anxiety, stress, mindfulness, and well-being	Recruitment completed	Intervention	2025-11-17	<NULL>	<NULL>	8563	Mindfulness program: reducing anxiety and stress levels and increasing mindfulness capacity and well-being in federal public servants in southern Brazil	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-20	Aline da Rosa Pizarro	<NULL>	<NULL>	<NULL>	Be a teacher or administrative technician in education at the Federal University of Pelotas; not have any other paid job outside the university.	practice meditation regularly; have started using some psychotropic drug or psychotherapy in the last 3 months; have some mental illness with severe, non-stabilized symptoms.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:23
RBR-65k2n4q	Effect of the TCI Mobile app combined with lower extremity constraint-induced movement therapy on real-world lower-limb use after chronic stroke	Recruitment completed	Intervention	2025-11-17	<NULL>	<NULL>	8564	Effect of the TCI Mobile app combined with lower extremity constraint-induced movement therapy on real-world lower-limb use after chronic stroke: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-05	Universidade Federal de São Carlos	<NULL>	<NULL>	<NULL>	Adults of both sexes aged 18 years or older with chronic stroke (≥6 months post-stroke); lower limb hemiparesis; ability to walk at least 8 meters independently with or without an assistive device; and adequate cognitive function according to the Mini-Mental State Examination using education-adjusted cutoff scores	Severe visual impairment; other neurological conditions unrelated to stroke; orthopedic conditions unrelated to stroke that could interfere with the intervention or assessments; respiratory disorders that could interfere with performance	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:18
RBR-5xkczqj	Exercises with Blood Flow Restriction and Electrical Stimulation for Diabetic Nerve Pain: Practical Study	Recruiting	Intervention	2025-11-17	<NULL>	<NULL>	8565	Resistance Exercises with Partial Blood Flow Occlusion Combined with Transcranial Electrical Stimulation for Diabetic Neuropathic Pain: A Quasi-Experimental Study	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Estadual de Campinas	<NULL>	<NULL>	<NULL>	Volunteers with confirmed type I or type II diabetes mellitus (at least 5 years for type I DM) according to the diagnostic criteria of the American Diabetes Association (ADA); both sexes; age over 18 years; distal-to-proximal pain pattern in the lower limbs (stocking distribution)	Volunteers with metallic implants near the stimulation site; decompensated neurological and/or neuropsychiatric disorders (except for diabetic neuropathy); family history of epileptic disorders with monogenic inheritance; personal history of epilepsy, even if treated and compensated; use of illicit drugs; implantation of electrical stimulators (e.g., pacemaker); history of stroke; cognitive and/or consciousness disturbances preventing comprehension of the questionnaires; pregnancy or puerperium; prior cranial manipulation with instrumentation along the electrode path; current brain tumor; decompensated inflammatory dermatological diseases in the cranial region that prevent electrode coupling; motor abnormalities that prevent completion of the exercise protocol; sickle cell anemia; significant macrovascular obstruction with altered peripheral pulses, claudication symptoms, or venous disease grades 5 or 6; arteriovenous fistula in the lower limbs; decompensated coagulation disorders; diagnosis of another neuropathy (besides diabetic neuropathy); uncontrolled heart disease; rheumatoid arthritis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:24
RBR-858vntn	Using Virtual Reality to relieve pain and anxiety during Hemodialysis access puncture	Not yet recruiting	Intervention	2025-11-16	<NULL>	<NULL>	8504	Effect of Virtual Reality on pain and anxiety during Arteriovenous Fistula puncture: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Departamento de Enfermagem	<NULL>	<NULL>	<NULL>	Participants of both sexes; age ≥18 years; undergoing hemodialysis through arteriovenous fistula puncture for at least 4 weeks and at most 4 months; functional and stable arteriovenous fistula in the last three sessions, without signs of infection; absence of neurological or cognitive conditions capable of interfering with the intervention or data collection.	Visual or auditory hypersensitivity; use of pharmacological therapy for anxiety or antidepressants; use of analgesics in the 24 hours prior to the procedure; history of severe migraine or balance disorders; requirement of a new puncture of the fistula during the procedure; hemodynamic instability.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:25
RBR-32j9y23	Comparison between two regional anesthesia techniques to relieve pain after partial breast removal surgery (Quadrantectomy)	Not yet recruiting	Intervention	2025-11-16	<NULL>	<NULL>	8505	Comparison between Pectoral Plane Block (PECS I AND II) and Erector Spinae Plane Block (ESP) for postoperative analgesia in Breast Quadrantectomy: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Female gender; age between 18 and 75 years; unilateral breast quadrantectomy or sectorectomy with or without axillary lymphadenectomy; signed informed consent form; elective surgery	Known allergy or hypersensitivity to local anesthetics such as ropivacaine or related agents; infection at the puncture site; coagulopathy or use of anticoagulants that contraindicate regional anesthesia; previous breast surgery; patient refusal to participate in the study; cognitive or psychiatric disorders that impair understanding of the Visual Analogue Scale; bilateral or radical breast surgery; BMI greater than 40 kg/m²; body weight below 37.5 kg	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:26
RBR-7fzzkb7	Effects of using a vibratory device to help babies with Bronchiolitis	Recruiting	Intervention	2025-11-14	<NULL>	<NULL>	8506	Effects of Expector® LAC use in infants with Acute Viral Bronchiolitis: a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-23	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	<NULL>	<NULL>	<NULL>	Infants; both sexes; diagnosed with Acute viral bronchiolitis; hospitalized in a healthcare facility; parents or legal guardians must be at least 18 years old and must authorize the participation of the minors as well as their own by signing the Informed Consent Form	Infants with congenital musculoskeletal abnormalities in the thoracic region such as Kyphoscoliosis; presence of pre-existing cardiorespiratory disorders such as congenital heart diseases and Cystic fibrosis	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:28
RBR-5ssxw9b	Number of sessions required to achieve maximum tooth whitening with 35% hydrogen peroxide	Recruitment completed	Intervention	2025-11-14	<NULL>	<NULL>	8507	Evaluation of the level of dental saturation in office bleaching using 35% hydrogen peroxide gel:Controlled clinical trial	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-02	Universidade Estadual de Ponta Grossa	<NULL>	<NULL>	<NULL>	Patients of both sexes; and aged 18 years; or older who agree to the informed consent form;present good general and oral health;absence of cavities;restorations;and conventional and invisible orthodontic appliances on the lower anterior teeth;the upper canines must have a color A2 or higher according to the shade guide (VITA Easyshade Advance 4.0, Vita Zahnfabrik, Bad Säckingen, Germany)	Patients with restorations;caries;use of orthodontic appliances;or severe internal tooth discoloration (tetracycline stains;fluorosis;and non-vital teeth) will be excluded from the study. Furthermore;pregnant/lactating patients;those with other conditions that may cause sensitivity;such as recession;dentin exposure;visible cracks;dental hypersensitivity;bruxism;or those taking medications (anti-inflammatories and analgesics) that may influence the perception of tooth sensitivity;or patients who have previously undergone tooth whitening will not be included in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:28
RBR-7kvxw88	Study on the effects of alternating between sitting and standing during office work on adults’ health, comfort, and well-being	Other	Intervention	2025-11-14	<NULL>	<NULL>	8508	Effects of postural alternation during office work on autonomic function, hemodynamics, comfort, productivity, cognitive function, energy expenditure, and mood in adults: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-25	Universidade Federal de Santa Catarina	<NULL>	<NULL>	<NULL>	Men and women; between 18 and 40 years old; office workers	History of cardiovascular or metabolic diseases; infectious or inflammatory processes; severe chronic pain conditions; smokers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:29
RBR-62ghfw4	Study on the proposal for pre-rehabilitation work and health-related quality of life of adults with visual impairment who are on the waiting list	Recruiting	Intervention	2025-11-14	<NULL>	<NULL>	8509	Rehabilitation and health-related quality of life of adults with visual impairment: clinical trial of a pre-rehabilitation proposal with a waiting list	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-18	Escola Nacional de Saúde Pública Sérgio Arouca/ Fundação Oswaldo Cruz	<NULL>	<NULL>	<NULL>	individuals aged 18 or older; both genders; registered on the waiting list for the Benjamin Constant Institute Rehabilitation Program; never participated in any rehabilitation program for visual impairment;  blindness in both eyes; blindness in one eye and low vision in the other eye; low vision in both eyes	individuals living with other severe associated disabilities; pregnant women; patients with chronic illnesses requiring hospitalization	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:30
RBR-2q63v4h	Bacteria-produced dressing for treating wounds in diabetic patients	Not yet recruiting	Intervention	2025-11-14	<NULL>	<NULL>	8510	POLYTISSUE film associated with bacterial cellulose hydrogel for the treatment of venous ulcers in diabetic patients	<NULL>	2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-20	Universidade Federal de Alagoas (UFAL)	<NULL>	<NULL>	<NULL>	Adults with a diagnosis of non-infected venous ulcer in the granulation phase; with or without diabetes.	Pregnant women; allergy to the compound; venous ulcers resulting from trauma or any other non-chronic superficial skin lesions; significant systemic infection; cognitive deficit that prevents participation in the research; voluntary request to withdraw from the research.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:31
RBR-2dzyhxp	Evaluation of low-level laser Photobiomodulation on breast milk production in postpartum women: a randomized clinical trial	Recruiting	Intervention	2025-11-13	<NULL>	<NULL>	8511	Efficacy of Photobiomodulation for increasing milk production: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Mothers over 18 years of age; who have their newborn in the Neonatal Intensive Care Unit (NICU) of the Hospital das Clínicas of the Federal University of Minas Gerais (HC-UFMG) and who are in the mothers&apos; accommodation in the South Wing of HC-UFMG; absence of medical restrictions to exclusive breastfeeding, such as mothers infected with HIV, HTLV1 and HTLV2, or using medications incompatible with breastfeeding; child with galactosemia	Mothers who do not answer all the questions on the questionnaire; mothers who present photosensitivity or any adverse reaction to exposure to sunlight; use of a pacemaker or other electronic implant; undiagnosed lesion in or near the area to be irradiated; history of cancer, surgical wound, or hematoma at the time of inclusion in the study; report of autoimmune diseases that cause skin lesions and/or allergy to adhesive tape; use of bandages or other technical factors that prevent the skin from being exposed to an environment with a balanced temperature; use of lotions, deodorants, preparations, moisturizers, topical analgesics, among others, on the day of the examination; having undergone acupuncture, massages, or electrical stimulation; having been exposed to prolonged sunlight up to 24 hours before the measurements; use of steroids, sympathetic blockers, vasoactive medications, opioids, and transdermal patches in the 24 hours prior to the test; exposure of the skin to hot water; participants who have not fasted for more than 3 hours before the examination; Those who ingested stimulants, nasal decongestants, analgesics, anti-inflammatories, corticosteroids, or any substance that alters sympathetic neurovegetative function in the 24 hours preceding the exam; those who engaged in physical activity on the day of the exam; and those who presented with fever, allergic rhinitis, flu-like symptoms, and/or a cold on the day of the tests	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:32
RBR-57pgmjr	Efficacy of different physical therapy delivery modalities on adherence and pain in individuals with chronic low back pain	Recruiting	Intervention	2025-11-13	<NULL>	<NULL>	8512	Efficacy of different physiotherapy delivery modalities on adherence and pain in individuals with chronic low back pain: a non-inferiority randomized clinical trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Departamento de Fisioterapia da Universidade Federal de São Carlos	<NULL>	<NULL>	<NULL>	Individuals of both sexes; between 18 and 65 years old; with non-specific low back pain lasting three months or longer; a score greater than or equal to 3 on the Numerical Rating Scale (NRS); a score &gt; 14% on the Oswestry Disability Index (ODI); be able to speak and understand Portuguese; and have access to a smartphone, tablet, or computer with internet connectivity	Pregnancy; presence of tumors, infections, or metastases; specific causes of chronic low back pain such as radiculopathy, lumbar stenosis, or chronic degenerative disorders; history of fracture or recent orthopedic surgery (in the last 12 months); surgery scheduled for the next 6 months; heart disease, neurological or rheumatic disorders, as well as any medical contraindication to physical activity; score less than 2 on the Mini-Cog; uncorrected hearing and visual impairments; or any health condition that prevents the safe and adequate performance of exercises	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:33
RBR-10q4syp6	How eating functional foods can help people living with HIV to improve their metabolism and nutrition	Not yet recruiting	Intervention	2025-11-13	<NULL>	<NULL>	8513	Repercussions Metabolic and Nutritional in HIV-Infected individuals: effectiveness of consumption of functional foods	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Universidade Federal do Rio de Janeiro - UFRJ-Macaé	<NULL>	<NULL>	<NULL>	Adults with positive HIV serology; of both sexes; aged over 18 and under 60 years; undergoing antiretroviral therapy; registered at the outpatient clinic of the Specialized Care Service of Macaé, between 2016 and 2025; who accept nutritional care and agree to sign the Informed Consent Form, as approved by the Ethics Committee of Macaé.	Pregnant women; children and adolescents; patients over 60 years of age; people with negative HIV serology; those who do not sign the Informed Consent Form and are in PHASE II of the study; individuals who do not comply with the established period for ingestion of the product (bread enriched with organic flaxseed); those who are using medications for dyslipidemia and glucocorticoids; those who have a diagnosis of lactose intolerance, egg protein intolerance and/or gluten intolerance.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:33
RBR-3vn2r5y	Prevalence of major depressive disorder and treatment-resistant depression in the mental health reference service of Araraquara	Not yet recruiting	Observational	2025-11-13	<NULL>	<NULL>	8514	Prevalence of major depressive disorder and treatment-resistant depression and potential associated factors: a cross-sectional study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Faculdade de Ciências Farmacêuticas do Câmpus de Araraquara da Universidade Estadual Paulista	<NULL>	<NULL>	<NULL>	Patients treated by the Araraquara Centro de Referência de Saúde Mental do Adulto de Araraquara &quot;Dr. Ubirajara Caldas&quot; (CRASMA-A) and the Centro de Atenção Psicossocial  (CAPS-2); age 18 or older; diagnosed with depression according to the 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11) and the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); using at least one medication to treat depression	There is no exclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:34
RBR-99t5x37	Parasternal block with local anesthetic in cardiac surgery via sternotomy	Not yet recruiting	Intervention	2025-11-13	<NULL>	<NULL>	8515	Superficial parasternal block with 0.2% ropivacaine versus 0.4% ropivacaine in patients undergoing cardiac surgery via sternotomy: a randomized, double-blind, non-inferiority clinical trial	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Individuals of both sexes; aged between 18 and 75 years; body weight greater than or equal to 55 kg; scheduled for elective myocardial revascularization or valve replacement procedure via sternotomy; surgeries involving cardiopulmonary bypass (CPB); having provided written informed consent	Chronic opioid user, defined as more than 3 months of opioid use (excluding tramadol); undergoing thoracic incisions other than sternotomy, excluding chest drain insertion or other incisions for vascular graft harvesting; undergoing emergency surgery, heart transplantation, or surgery without the need for cardiopulmonary bypass; having undergone previous sternotomy; presence of easily detectable cognitive impairment; presenting contraindications to parasternal block analgesia, including coagulation disorders, infection, or malignancy at the puncture site; allergy to the local anesthetic used	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:35
RBR-84m2xtc	Modified Breathing Exercise: effect on respiratory function	Recruitment completed	Intervention	2025-11-13	<NULL>	<NULL>	8516	Modified Diaphragmatic Breathing: impact on respiratory function	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2017-10-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Adult patients (aged equal or higher than 18 years) admitted to the intensive care unit for at least 48 hours; breathing spontaneously; with a Glasgow Coma Scale score equal to or greater than 14	Neurological diseases; thoracic traumas; ascites; hemodynamic instability; pain at the moment of the assessment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:36
RBR-8ks2vwn	Enavogliflozin PK/PD profile evaluation in healthy brazilian subjects	Not yet recruiting	Intervention	2025-11-12	<NULL>	<NULL>	8517	A phase I, single-center, double-blind, randomized, parallel, placebo-controlled clinical study to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability after a single dose and multiple doses of 0.3 mg, 0.6 mg, and 1.2 mg Enavogliflozin in healthy adult participants of both sexes - SYN 374.002.24 / AC2025-PK/PD-105-1 - ENVLO	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Synvia Laboratórios e Toxicologia Ltda.	<NULL>	<NULL>	<NULL>	Participants must be Brazilian and have Brazilian ancestry (i.e., Brazilian parents and grandparents). They may be male or female, aged between 18 and 55 years, with a body weight ranging from 60 to 100 kg and a body mass index (BMI) between 18.5 and 30 kg/m². They must be in good health, as determined by the absence of significant findings in medical history, physical examination, laboratory tests, vital signs measurements, and electrocardiogram results. Participants must be able to read, understand, and agree to take part in the study by signing the informed consent form (ICF) approved by the ethics committee. They must also agree to comply with the planned study procedures and attend all scheduled visits. Female participants must either have no potential for pregnancy—defined as postmenopausal women (with 12 months or more of amenorrhea) or those who have undergone surgical sterilization—or, if male or female with reproductive potential, must agree to use a reliable contraceptive method	"&quot;Participants must not belong to a vulnerable group or have difficulty swallowing solid-form medications. They must not have used any medication (including herbal remedies) within 14 days prior to hospitalization, except for contraceptives or cases where, based on the drug’s half-life and/or active metabolites, complete elimination can be assumed or, at the investigator’s discretion, the medication does not interfere with the pharmacokinetics or analytical phase of the investigational drug. They must not have used dietary supplements, including herbal or vitamin supplements, within 7 days prior to hospitalization, nor calcium or vitamin D supplements within 14 days prior. They must not have received any vaccine dose within 7 days prior to hospitalization, nor undergone treatment with any drug known to have well-defined toxic potential to major organs within the 3 months prior to the study. Participants must not have taken part in any experimental study or ingested any investigational drug within 12 months prior to the start of this study, nor have been hospitalized for any reason within 8 weeks prior to the hospitalization period.
Participants must not have a history of hepatic, gastrointestinal, or other conditions that may interfere with the absorption, distribution, metabolism, or excretion of the drug. They must not have a history of renal, urinary, respiratory, hematologic, cardiac, endocrine, gastrointestinal, neurological, neoplastic, or psychiatric diseases considered clinically significant by the investigator. They must not have a history of cardiac surgery (any type), renal surgery (removal or agenesis), gastrointestinal surgery (partial or total removal of the esophagus, stomach, duodenum, jejunum, ileum, ascending colon, transverse colon, descending colon, sigmoid colon, or rectum), or surgery involving the liver or pancreas. Participants must not present any current, acute, or chronic symptoms or illnesses under treatment or follow-up that are considered significant by the investigator. They must not have a QTc interval greater than 450 ms (for males) or greater than 470 ms (for females), confirmed by repeat testing, or electrocardiographic findings deemed unsuitable for study participation by the physician. They must not have systolic blood pressure &lt; 90 mmHg or &gt; 150 mmHg, or diastolic blood pressure &lt; 60 mmHg or &gt; 100 mmHg during the screening visit after sitting for at least 5 minutes (and no more than 20 minutes) in a quiet, stress-free environment. Participants must not present AST or ALT results equal to or greater than 1.5 times the upper limit of the reference range, nor have laboratory test results outside reference values unless deemed not clinically significant by the investigator. They must not have lab results that, in the physician’s judgment, compromise the participant’s safety. They must not be breastfeeding, pregnant, or have a positive pregnancy test. They must not test positive on a rapid alcohol detection test or on a preliminary drug test for amphetamines/methamphetamines, opioids/morphine, cannabis/THC, cocaine/benzoylecgonine, and/or benzodiazepines. Participants must not be smokers (those with a history of smoking may be included if they have abstained for at least 3 months prior to the study). They must not have a history of illicit drug abuse or be regular alcohol consumers. Women must not consume more than 4 alcoholic drinks in a single day or more than 8 drinks per week, and men must not consume more than 5 drinks in a single day or more than 15 drinks per week. They must not have consumed alcohol or drugs within 48 hours prior to hospitalization. They must not habitually consume more than 5 cups of coffee or tea per day, nor have ingested foods or beverages containing xanthines within 48 hours prior to hospitalization. They must not have consumed grapefruit, grapefruit juice, or grapefruit-containing products within 14 days prior to hospitalization until discharge from the research center, nor be unable to abstain from grapefruit products during the study period. Participants must not have engaged in intense physical exercise within 48 hours prior to hospitalization, nor have unusual or restrictive dietary habits, as determined by the investigator. They must not have donated or lost 450 mL or more of blood in the past 3 months, nor more than 1500 mL in the past 6 months. They must not have difficulty ingesting approximately 200 mL of water in the morning. They must not have any condition that prevents participation in the study, as determined by the investigator. Finally, they must not have hypersensitivity or a history of hypersensitivity to SGLT2 inhibitors, similar compounds, or other medications (e.g., aspirin, antibiotics, heparin), as determined by the physician"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:38
RBR-88jp3fg	Clinical study for the treatment of Halitosis	Recruitment completed	Intervention	2025-11-12	<NULL>	<NULL>	8518	Efficacy in the treatment of Halitosis: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade Meridional	<NULL>	<NULL>	<NULL>	Volunteers with halitosis confirmed by organoleptic evaluation and positive self-perception of halitosis, aged 18 years or older.	Volunteers with uncontrolled diabetes, liver disorders, recurrent oropharyngeal infections, flu-like symptoms, use of dental prostheses, recent oral surgical procedures, and penicillin and metronidazole medications were excluded.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:39
RBR-109qrbcj	Multicomponent Exercise Combined with Strategies to Promote an Active Lifestyle in Older Adults with Cognitive Impairment (MOVEMENTE Study)	Recruiting	Intervention	2025-11-12	<NULL>	<NULL>	8519	Multicomponent Exercise Combined with Strategies to Promote an Active Lifestyle in Older Adults with Cognitive Impairment (MOVEMENTE Study): Effects on Cognitive Health, Movement Behaviors, Morphofunctional Indicators, and Cardiometabolic Risk	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-21	Universidade Federal do Vale do São Francisco - UNIVASF	<NULL>	<NULL>	<NULL>	To present cognitive complaints (self-reported or reported by family members) for at least six months and/or a score indicative of mild cognitive impairment on the Montreal Cognitive Assessment (MoCA), adjusted according to educational level; to be able to walk independently without assistive devices; to be able to stand up from and sit down on a chair unassisted while maintaining balance.	To present clinical conditions and/or diseases that contraindicate the safe practice of exercise; to have a diagnosis of neurological diseases and/or severe psychiatric disorders (e.g., dementia); to have a history of transient ischemic attack within the past year; to have a history of stroke with residual cognitive and/or motor impairments; to have significant sensory deficits (vision and/or hearing) that may interfere with the collection of study outcome data.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:40
RBR-7dd6wcz	Sleep–Wake Quality after Nighttime Medical Adjustments	Recruiting	Intervention	2025-11-12	<NULL>	<NULL>	8520	Controlled clinical trial on sleep–wake quality and nighttime medical order adjustments in hospitalized patients at Hospital Clínica Nova	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-12	servicios integrales nova de monterrey sociedad anonima de capital variable	<NULL>	<NULL>	<NULL>	Patients of both sexes admitted within the last 24 hours. Age between 18 and 65 years. Hospitalized in the inpatient unit of Hospital Clínica Nova. Expected hospital stay ≥ 3 days. Visual Analog Scale (VAS) for pain &lt; 3. Glasgow Coma Scale &gt; 13	Visual, auditory, intellectual, or cognitive impairment. History of sleep disorders. History of obstructive sleep apnea syndrome. Use of antidepressants, anxiolytics, hypnotics, or central nervous system stimulants. Hemodynamic instability upon admission. Patients transferred from the intensive care unit	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:41
RBR-102t5vqc	Metformin cream in Melasma treatment: a comparison with other options	Terminated	Intervention	2025-11-11	<NULL>	<NULL>	8521	Clinical study on the efficacy, safety, and mechanism of action of 30% topical Metformin, compared to 4% Hydroquinone and the combination of 30% Metformin with 10% Niacinamide in the treatment of facial Melasma	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-14	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women; age between 18 and 60 years old; with moderate to severe facial melasma or mMasi greater than 5; without treatment for at least 45 days except of the using of sunscreen	Pregnant and lactating women; carriers of other concomitant facial dermatoses; dermatoses with photosensitivity; melasma with mMASI less than 5; history of hypersensitivity or local adverse reactions to the use of hydroquinone, meftomin or niacinamide or any other component of the formulation described	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:43
RBR-5gb522g	Use of technology with social robots to stimulate memory in residents of nursing homes	Recruitment completed	Intervention	2025-11-11	<NULL>	<NULL>	8522	Effects of interaction with social robots on the cognitive engagement of older adults with dementia living in long-term care homes	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Escola de Artes Ciencias Humanidades da Universidade de Sao Paulo	<NULL>	<NULL>	<NULL>	Age 65 years or older. Clinical diagnosis of mild cognitive impairment or mild to moderate dementia. Preserved hearing ability. Preserved visual ability. Functional literacy. Both sexes	Diagnosis of severe dementia or severe cognitive impairment. Hearing loss impairing communication. Uncorrectable visual impairment. Functional illiteracy	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:44
RBR-10xx8ftw	Memory medications in older adults with Alzheimer’s: do they help or hinder during episodes of confusion?	Recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8523	To maintain or discontinue Cholinesterase Inhibitors in patients with Delirium superimposed on Alzheimer&apos;s Disease - a pilot clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-17	Departamento de Saúde Pública - Faculdade de Medicina de Botucatu	<NULL>	<NULL>	<NULL>	Patients of both sexes; aged 60 years or older; hospitalized in the geriatrics and orthopedics wards of the Clinical Hospital of the Botucatu Medical School at São Paulo State University (HCFMB-UNESP); presenting with hypoactive delirium superimposed on Alzheimer&apos;s disease or mixed Alzheimer&apos;s/vascular dementia with prior use of anticholinesterase medications for at least one month	Presence of hyperactive delirium at the time of recruitment; use of vasoactive drugs at the time of recruitment; heart rate below 50 bpm at the time of recruitment; abusive use of alcohol or illicit psychoactive substances in the past month; history of alcohol withdrawal in the last six months; presence of other forms of dementia.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:13
RBR-45hhwgf	Hydration of athletes who train in very hot environments	Recruitment completed	Intervention	2025-11-11	<NULL>	<NULL>	8524	Level of Dehydration of athletes who train in environments with high temperatures	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-01	Centro Universitário de Várzea Grande - UNIVAG	<NULL>	<NULL>	<NULL>	"Be regularly training in the judo modality with the aim of improving performance/results;
Have a history of participation in sports competitions regulated by federations in the judo modality."	All volunteers who do not comply with the weighing protocols; report a limiting musculoskeletal injury in the inflammatory phase; are undergoing treatment with diuretics; report alcohol consumption on the day before or on the day of the weighing protocols; report any cardiovascular problem; or answer “yes” to at least one question of the Physical Activity Readiness Questionnaire – PAR-Q+ 2014 will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:46
RBR-35gv9ct	Mindful eating intervention in university students	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8525	Effectiveness of a Mindful Eating intervention on eating behavior and body assessment of university students with symptoms of binge eating	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Be a student, regardless of age; regardless of gender; be regularly enrolled in an undergraduate program; own an electronic device (computer, tablet, or smartphone) and have internet access; present symptoms of Binge Eating Disorder (BED) identified by the Binge Eating Disorder Scale (BEDS), with a score greater than or equal to 17	Being pregnant; Having a physical disability or other condition that makes it impossible to obtain anthropometric measurements; Having a diagnosis of severe cognitive or mental disorders, such as schizophrenia or other psychotic disorders; Having a diagnosis of anorexia nervosa or acute depression for less than six months; be using medications or substances that cause loss of attention and cognitive concentration, such as anxiolytic drugs; be a regular practitioner (at least once a week in the last six months) of meditation, yoga, or mindfulnes	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:46
RBR-24xy2p3	Prevention of Alcohol Consumption in Childhood in a Multicomponent Community Intervention	Recruitment completed	Intervention	2025-11-11	<NULL>	<NULL>	8526	Prevention of Alcohol Use in Childhood within a Community-Based Multicomponent Intervention: An Implementation Research Approach	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-04	Departamento de Psiquiatria	<NULL>	<NULL>	<NULL>	Eligible participants include children enrolled in grades 1–5 of elementary school who attend participating municipal schools in Salesópolis or Biritiba-Mirim; participation requires a signed informed consent form from parents or legal guardians and child assent; homeroom teachers of participating classes will also take part because they are involved in training and classroom observations	Participants will be excluded if a signed informed consent form from the legal guardians and the child’s assent are not provided	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:47
RBR-8k44cz5	Effects of treatment with stimulation at specific points of the feet combined with physical exercise on gait in individuals with Parkinson&apos;s Disease	Recruitment completed	Intervention	2025-11-11	<NULL>	<NULL>	8527	Acute effect of automated mechanical peripheral stimulation combined with physical exercise on locomotion in individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2020-06-19	Universidade Estadual Paulista Júlio de Mesquita Filho	<NULL>	<NULL>	<NULL>	Diagnosis of idiopathic Parkinson&apos;s Disease as determined by the London Brain Bank Criteria; mild-moderate disease stage (Hoehn &amp;Yahr I-III); age above 60 years; ability to walk independently; no changes in medication regimen in the past six months	History of diabetic polyneuropathy; cognitive decline (Montreal Cognitive Assessment score ≤ 26 points); had undergone Deep Brain Stimulation surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:48
RBR-49fgk6d	Nordic or Conventional Walking: which is more effective for people with knee osteoarthritis and metabolic risk?	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8528	Efficacy of Nordic Walking versus Conventional Walking in individuals with knee Osteoarthritis and Metabolic Risk: A pragmatic randomized clinical trial	<NULL>	1-2, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Federal de Santa Catarina- UFSC	<NULL>	<NULL>	<NULL>	Clinical diagnosis of knee osteoarthritis according to the guidelines of the National Institute for Health and Care Excellence (NICE), which include being 45 years or older, having joint pain related to physical activity, and not presenting morning joint stiffness or presenting morning stiffness lasting less than 30 minutes; higher level of pain reported in the knee compared to other joints; waist circumference greater than 88 centimeters for women or greater than 102 centimeters for men, characterizing increased metabolic risk according to the World Health Organization guidelines	Cognitive deficits that impair understanding of instructions or provision of informed consent; inability to walk independently for at least 15 minutes; clinical conditions that contraindicate regular physical exercise; previous orthopedic surgeries in the lower limbs, pelvis, or spine within the last 18 months, including arthroplasty such as knee or hip replacement, arthroscopy, osteotomy, ligament or meniscal repairs, fracture fixation, spinal decompression or fusion; surgeries with relevant impact on body weight or metabolism such as bariatric surgery performed within the last 18 months; any surgery within the last 6 months that required immobilization for more than 14 consecutive days, restricted physical activity, or required supervised rehabilitation; other surgical procedures, at the discretion of the study coordination, that may interfere with functional capacity, pain, or muscle performance; intra-articular injection in the knee within the last 6 months; musculoskeletal trauma in the lower limbs within the last 6 months; history of knee arthroplasty regardless of date; minor outpatient procedures will not be considered exclusion criteria, such as simple dental surgeries including root canal treatment, cleaning, or simple extractions, minor dermatological surgeries such as removal of cysts or lipomas, low-impact ophthalmologic surgeries such as cataract surgery, diagnostic procedures such as colonoscopy or endoscopy, insertion of an intrauterine device (IUD) or minor gynecological procedures, provided that they did not restrict physical activity for more than 7 days in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:49
RBR-3jk98z7	Effects of Blood Restriction Muscle Training associated with Light Therapy	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8529	Effects of Blood Flow Restriction Training associated with Photobiomodulation Therapy	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Fundação do ABC	<NULL>	<NULL>	<NULL>	Men and women; Healthy individuals; Aged between 18 and 30 years; Body mass index classification up to 30 kilograms per square meter	Individuals with musculoskeletal injuries undergoing treatment or with a history of upper limb surgery; Clinical manifestations that prevent exercise, such as changes in blood pressure, heart rate, and/or respiratory rate	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:50
RBR-52bbrn8	Using a carbohydrate mouthwash to improve strength and endurance in the arms and shoulders of fighters.	Recruitment completed	Intervention	2025-11-11	<NULL>	<NULL>	8530	Effect of a carbohydrate mouth rinse on intermittent dynamic strength-endurance performance of the upper body in combat sport athletes	<NULL>	1, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-02	Centro Universitário CESMAC	<NULL>	<NULL>	<NULL>	Male sex; age between 18 and 40 years; judo or jiu-jitsu athletes; minimum training frequency of three times per week with one-hour sessions; minimum practical experience of six months in the modality	Occurrence of a musculoskeletal injury; failure to attend the scheduled test dates; having an allergy to the substances proposed in the study; reporting any negative effect that impairs physical well being during the experiment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:50
RBR-8ppyzb2	Clinical study of the combination of paracetamol, phenylephrine and chlorpheniramine in the treatment of flu and common cold.	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8531	Efficacy and safety study of the combination of paracetamol, phenylephrine and chlorpheniramine in the symptomatic treatment of flu and common cold.	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-03-01	Scentryphar Pesquisa Clínica Ltda	<NULL>	<NULL>	<NULL>	Patients capable of understanding the nature of the study, willing to comply with all study procedures, and who agree to provide signed informed consent; Male or female, aged greater than or equal to 18 years and less than or equal to 65 years at the time of signing the informed consent; Patients must have a cold or flu-like illness diagnosed by a healthcare professional at the study center, with the following symptoms having started within 72 hours before the screening/baseline visit: nasal congestion, sneezing, and runny nose. The severity of general nasal symptoms must be at least moderate on a five-point Likert-type symptom severity scale (0 = no symptoms; 1 = mild; 2 = moderate; 3 = severe; 4 = very severe); Patients must also have non-nasal cold symptoms (sore throat, headache, cough, myalgia, and fever). The severity of pain symptoms must be at least moderate on a five-point Likert-type symptom severity scale (0 = no symptoms; 1 = mild; 2 = moderate; 3 = severe; 4 = very severe); Patients must have a sum of physician assessment of signs scores of at least 5	Pregnant or breastfeeding women (lactating women); Women who do not agree to use temporary contraceptive methods; Men who do not agree to use temporary contraceptive methods (considering the short treatment time of this study), such as barrier methods, during the study, except for those who are surgically sterile (vasectomy), or who have female partners who use effective contraceptive methods, or surgically sterile partners, or partners who have been menopausal for at least 1 (one) year, or participants who declare that they do not engage in sexual practices or engage in them in a non-reproductive manner; History of or known hypersensitivity to any of the study medications, excipients, or medications of similar chemical classes; Rapid onset of symptoms that, in the investigator&apos;s opinion, are indicative of severe cases of influenza; Use of alcohol or illicit drugs; Use of monoamine oxidase (MAO) inhibitors or barbiturates; Perennial or seasonal allergic rhinitis confirmed at screening; History of or chronic respiratory disease (within the past 5 years); Presence of nasal polyps, significant nasal septum deviation, or any other anatomical abnormality affecting airflow; Any current acute illness or uncontrolled exacerbation of a chronic disease; Any evidence (within 2 years) of significant cardiovascular, pulmonary, renal, hepatic, gastrointestinal, hematologic, endocrinologic, metabolic, neurologic, psychiatric, or other disease at screening, including hypertension, cardiac arrhythmias, serious organic changes of the heart and blood vessels, uncontrolled thyroid disease, thyrotoxicosis, decompensated diabetes, or benign prostatic hypertrophy, based on the investigators&apos; assessment; Long QT syndrome or QTc greater than 450 msec for men and greater than 470 msec for women at screening/baseline; Clinical evidence of immunosuppression; Clinically relevant chronic or acute infectious diseases or febrile infections within 2 weeks prior to study entry, including bacterial sinusitis within 2 weeks prior to the screening visit/baseline period; Influenza vaccination up to 1 week prior to enrollment; Need for antiviral therapy to treat influenza A or B infection; Need for antibacterial therapy to treat acute respiratory infection; Use of medication to treat conditions acquired prior to enrollment for a period shorter than two time intervals of administration of these medications; Patients using medications likely to interact with phenylephrine and chlorpheniramine (alcohol, opioid analgesics, anticonvulsants, antidepressants (tricyclic monoamine oxidase inhibitors), antihistamines, antiemetics, antipsychotics, anxiolytics and hypnotics, alpha and beta blockers, vasodilators, sympathomimetic agents) and paracetamol (for paracetamol alone: ​​within 24 hours before study drug intake and during the study, also anticoagulants such as warfarin and coumarin, chloramphenicol, probenecid, rifampicin and isoniazid, cholestyramine, metoclopramide, domperidone, zidovudine, didanosine, propantheline) should be excluded; Use of another investigational drug in the period less than one year before enrollment; Any other changes in laboratory tests regarding complete blood count, blood glucose (pre- or postprandial), sodium, potassium, creatinine, total bilirubin, AST, AST, alkaline phosphatase, and γ-GT, which, in the investigator&apos;s discretion, are considered clinically significant; Patient reports consumption of any drug-metabolizing enzyme (e.g., CYP3A4 or other cytochrome P450 enzymes) inducing or inhibiting foods, beverages, or dietary supplements (e.g., broccoli, Brussels sprouts, grapefruit, grapefruit juice, star fruit, St. John&apos;s wort, etc.) within 48 hours prior to the first scheduled administration of the study drug, or is expected to consume such products during the period or at any time throughout the study; Surgery of the gastrointestinal tract that may interfere with drug absorption (note: this is not applicable to minor abdominal surgery without significant tissue resection, e.g., appendectomy or herniorrhaphy)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:52
RBR-5yh9chg	Gingival Healing Response Around Surface-Treated Prosthetic Abutments: A One-Year Clinical Evaluation	Not yet recruiting	Intervention	2025-11-11	<NULL>	<NULL>	8532	Tissue Repair Analysis at the Interface of Anodized Prosthetic Abutments: A Prospective, Randomized, Controlled Clinical Trial with One-Year Follow-Up	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Centro De Pesquisas Odontologicas Sao Leopoldo Mandic Ss	<NULL>	<NULL>	<NULL>	Patients of both sexes, aged between 18 and 80 years, partially edentulous in the posterior maxilla or mandible; with the absence of at least two teeth, whether contiguous or not; healed ridges that did not require tissue reconstruction for subsequent placement of dental implants; implants installed with primary stability; minimum mucosal thickness at the ridge crest of 2 mm of keratinized tissue height	Patients who require some type of bone prosthesis or advanced surgical procedure to allow for implant placement; with systemic contraindications to the surgical procedure or conditions that interfere with the osseointegration process	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:52
RBR-104pstbt	The effects of light therapy on the cognitive processes (attention and memory) of healthy subjects	Recruiting	Intervention	2025-11-10	<NULL>	<NULL>	8533	The cognitive effects of Transcranial Photobiomodulation Therapy (PBMt) in healthy subjects: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-25	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Be a regular student of the UNISUL medical course; both sexes; be between 18 and 25 years old	Not signing the TCLE; having a history of or current epileptic episodes; being pregnant or lactating; being an oncology patient	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:54
RBR-10nq323c	Study on the effect of Laser Light in relieving Muscle Pain in the pelvic floor of women with Chronic Pelvic Pain	Data analysis completed	Intervention	2025-11-10	<NULL>	<NULL>	8534	Study of the effect of Photobiomodulation on relieving Myofascial pain in the Pelvic floor of women with Chronic Pelvic Pain	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-07-13	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women; pelvic pain or genito-pelvic/penetration pain (GPPPD) for more than six months will be included; with a trigger point in the pelvic floor; aged between 18 and 45 years; sexually active with penetration (at least once a month); experiencing pelvic pain and pain during intercourse, with a score equal to or greater than four on the Numerical Rating Scale (NRS)	Women with obesity (body mass index [BMI] &gt;30); current urinary tract infection; leukorrhea (such as candidiasis or bacterial vaginosis); acute vulvar or vaginal lesions (e.g., Human papillomavirus, herpes, fissures); pregnant women; women with suspected pelvic cancer; pelvic organ prolapse beyond the hymenal ring during Valsalva maneuver; hypertrophic scars; vulvodynia; vaginismus; moderate to heavy menstrual leakage or increased and irregular uterine bleeding. During the study, patients who did not attend at least 70% of the sessions were excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:55
RBR-3b665wc	Heart and Lung Rescue with Rapid Cycles	Not yet recruiting	Intervention	2025-11-10	<NULL>	<NULL>	8535	Cardiopulmonary resuscitation and deliberate practice in rapid cycles	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Fundação Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	The study included education professionals working in state or municipal public schools in the municipalities of Aracaju, Lagarto, and São Cristóvão in the state of Sergipe. Participants must be actively performing their duties at the time of data collection, understand and communicate in Portuguese, have the cognitive and physical capacity to complete the cardiopulmonary resuscitation training steps, and agree to participate in the study by signing the informed consent form	Professionals who are away from their duties due to vacation, leave, or absence during the data collection period will be excluded. Professionals with musculoskeletal conditions that prevent them from performing cardiopulmonary resuscitation maneuvers, such as chest compressions or specific movements required in the simulation, will be excluded. Individuals with cognitive impairment that interferes with understanding the instructions, as well as those who do not complete all stages of the study or refuse to sign the Informed Consent Form, will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:56
RBR-10rbqr8z	Psychological support for parents to help autistic children manage emotions	Recruitment completed	Intervention	2025-11-10	<NULL>	<NULL>	8536	Functional Analytic Psychotherapy as Parental Guidance for emotional regulation of autistic children	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-14	Instituto Brasiliense de Análise do Comportamento	<NULL>	<NULL>	<NULL>	Be 18 years or older; both genders; be the primary caregiver of a child with a formal diagnosis of Autism Spectrum Disorder (level I, II or III); child aged six to twelve years; child must have an established method of communication with the caregiver such as spoken language, communication board, communication cards or other; reside in Brazil	Under 18 years old; not proficient in Portuguese; not the primary caregiver of a child with a formal diagnosis of Autism Spectrum Disorder; severe or profound intellectual disability in the child; absence of a reliable method of communication between caregiver and child; comorbid diagnosis of bipolar disorder, schizophrenia or other psychotic disorder in the child or caregiver; high risk of violence defined as need for serious medical attention in the past two weeks due to dysregulated behavior of the child or caregiver; active suicidal risk or suicide plan according to the Columbia Suicide Severity Rating Scale	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:57
RBR-52r33vv	Impact of correcting skeletal facial patterns types II and III on quality of life after orthognathic surgery	Recruitment completed	Observational	2025-11-10	<NULL>	<NULL>	8537	Impact of treatment of dentofacial deformities on quality of life after orthognathic surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-02-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Adult patients between 18 and 60 years of age; literate and without cognitive impairment; presenting a diagnosis of dentofacial deformities for which orthodontic treatment to align, level, and remove dental compensations has been performed prior to orthognathic surgery	Patients who had previously undergone orthognathic surgery; history of treatment for facial fractures; congenital craniofacial syndromes; patients who underwent genioplasty in conjunction with orthognathic surgery; patients classified with a type I facial profile pattern; patients who did not respond to the questionnaires at all stipulated evaluation times	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:58
RBR-5v79cx5	How eating ultra-processed foods is linked to eating behavior and facial pain in women	Recruiting	Observational	2025-11-10	<NULL>	<NULL>	8538	Correlation between consumption of ultra-processed foods, eating behavior, and pain sensitivity in women with Temporomandibular Dysfunction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-16	Programa de Pós Gradução em Odontologia do Ceará	<NULL>	<NULL>	<NULL>	Women aged between 18 and 55 years diagnosed with temporomandibular disorder according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD); who have preserved cognitive ability to answer the assessment instruments; who agree to participate in the study by signing the informed consent form	Women with previously diagnosed disabling cognitive, psychological or neurological disorders; who abuse legal drugs including alcoholic beverages or use illegal drugs; pregnant or breastfeeding women; with food intolerances or other systemic conditions that may cause dietary restrictions; with more than five missing teeth in the same hemiarch; with odontalgia or intraoral or extraoral lesions that may compromise masticatory function; who have used muscle relaxants, anti-inflammatory drugs or analgesics within 24 hours prior to the initial assessment	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:59
RBR-5drmd88	The use of Vitamin C and Magnesium to help with teeth alignment	Recruiting	Intervention	2025-11-10	<NULL>	<NULL>	8539	Use of Vitamin C and Magnesium in induced tooth movement	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-01	Fundação Universidade Federal de São João del Rei Campus Centro Oeste Dona Lindu	<NULL>	<NULL>	<NULL>	Population of both sexes, adults and adolescents from 15 years of age, treated at the dental clinic belonging to the university of Itaúna. Individuals undergoing orthodontic treatment with metal brackets and retraction of incisors and canines, submitted to sliding mechanics, to close the space created by the therapeutic extraction classically recommended in the reduction of the facial profile	"Smokers; Pregnant or breastfeeding women; Individuals with systemic diseases, such as diabetes, under drug therapy with antiepileptics (phenytoin), calcium channel blockers (nifedipine) and immunosuppressants (cyclosporine); Individuals using antimicrobial or anti-inflammatory drugs; Individuals with a history of scaling and root planing in the last 3 months;
Individuals with significant tooth mobility, proven in the clinical examination; Individuals with poor oral hygiene; Individuals without minimum autonomy (due to mental or consciousness changes), according to the interviewer&apos;s subjective assessment. Individuals with fistula or pain of endodontic origin"	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:01
RBR-2fxn942	Effects of a dynamic school environment on cognitive function, academic performance, and health in youth	Recruitment completed	Intervention	2025-11-08	<NULL>	<NULL>	8488	Effects of School Environment Dynamization on Cognitive Function, Academic Performance, and Health Indicators in Youth: A Multicenter Cluster-Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-02	Departamento de Educação Física - Universidade Federal de Sergipe	<NULL>	<NULL>	<NULL>	Students in the 2nd year of elementary school from municipal schools in Aracaju/SE, Arapiraca/AL, Feira de Santana/BA, and Ilhéus/BA; aged between 7 and 9 years; must not present any impediment to performing postural transitions; must return the duly signed informed consent form from parents or guardians.	Students who stop attending school for any reason or express interest in leaving their studies will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:03
RBR-106z4g6c	Effect of chemicals containing Green Tea extract and Hyaluronic Acid on toothpastes and mouthwashes on the clinical and microbiological aspects of people using orthodontic appliances.	Recruitment completed	Intervention	2025-11-07	<NULL>	<NULL>	8489	Effect of chemical agents containing Green Tea extract and Hyaluronic Acid, in toothpaste and rinse formulations, on clinical and microbiological parameters of individuals with orthodontic appliances	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Individuals between twelve and thirty years of age; both genders; undergoing treatment with fixed orthodontic appliances in orthodontics specialization clinics at the Faculty of Dentistry of Ribeirão Preto; having a case of generalized gingivitis	Presenting systemic compromise; smoking; using drugs or controlled medication; having used mouthwashes with antimicrobial solutions for up to three months before the start of the research; using antibiotics for up to six months before the start of the research; not having used anti-inflammatory drugs in the seven days preceding the start of the research or using them during the research; patients who had undergone dental cleaning in the last six months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:05
RBR-4mztsnq	Effects of cannabis extract cream on nerve and blood-deprived wound healing: randomized trial	Not yet recruiting	Intervention	2025-11-07	<NULL>	<NULL>	8490	Effects of Cannabis extract cream on the healing process of neuropathic and ischemic wounds: a randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-05	Sociedade De Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Age 18 years or older. diagnosis of type 2 diabetes mellitus. presence of neuropathic or ischemic wound in lower limbs. under follow-up at primary health units or at Policlínica Santa Maria in the city of Cajazeiras. medical prescription for use of the Cannabis-based cream. signing of the informed consent form	Wounds not related to diabetes such as those of traumatic or burn origin. known allergy to any component of the cream formulation. simultaneous participation in another clinical trial. presence of severe clinical or psychiatric conditions that impair protocol adherence. pregnancy or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:06
RBR-44cmcf5	Innovations in women&apos;s health care	Recruiting	Observational	2025-11-06	<NULL>	<NULL>	8491	Innovations in women&apos;s health care: a pilot study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-11	Sociedade Beneficente de Senhoras Hospital Sírio-Libanês	<NULL>	<NULL>	<NULL>	All female employees, with a current employment contract and those dependent on the medical insurance of Roche employees within the age range of 25 to 74 years old will be invited to participate in this study; female	Women who are undergoing treatment for breast cancer or cervical cancer.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:08
RBR-3rxr4bj	Effects of acute supplementation with extract from the bark of the Maritime Pine tree, alone or combined with Yohimbine, on muscle strength, heart and lung capacity during exercise, and blood markers of muscle damage in healthy adults: a randomized, double-blind clinical trial	Recruiting	Intervention	2025-11-06	<NULL>	<NULL>	8492	Effects of acute supplementation with Pinus Pinaster alone or combined with Yohimbine on muscle strength, cardiorespiratory fitness, and muscle damage biomarkers in healthy adults: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-20	União Brasileira de Educação e Assistência	<NULL>	<NULL>	<NULL>	Adult male bodybuilders; age 20 to 45; who have been bodybuilding for at least six months; practitioners who include at least three weightlifting physical activity sessions per week	Individuals diagnosed with any chronic disease or condition such as hypertension ; type 1 or type 2 diabetes mellitus ; as well as those using dietary supplements or medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:10
RBR-9tgfkmy	Effects of dog therapy and aromatherapy on institutionalized elderly people	Other	Intervention	2025-11-06	<NULL>	<NULL>	8493	Effects of integrative therapies on institutionalized elderly people: use of essential oils and dog-assisted therapy	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-01	Departamento de Saúde Coletiva da Universidade Federação do Rio Grande Norte	<NULL>	<NULL>	<NULL>	Institutionalized elderly individuals aged ≥ 60 years; both sexes; score ≤ 25 on the Mini Mental State Examination (MMSE); signed informed consent	Elderly people afraid of dogs; allergy to dogs; dog phobia; non-residents in Long-Term Care Institutions for the Elderly	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:23:00
RBR-9r493vh	Phenylephrine or Norepinephrine infusion for prevention of blood pressure drop in Obese pregnant women during cesarean section under spinal anesthesia	Recruiting	Intervention	2025-11-06	<NULL>	<NULL>	8494	Phenylephrine versus Norepinephrine infusion for the prevention of hypotension in Obese pregnant women during cesarean Section under Spinal Anesthesia: a randomized, double-blind, controlled, non-inferiority clinical trial	<NULL>	4, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-30	Associação  de Proteção  a Maternidade e a Infancia de Cuiabá	<NULL>	<NULL>	<NULL>	Pregnant women with a single fetus; gestational age greater than 36 weeks; age greater than or equal to 18 years; body mass índex (BMI) 35kg/m2; candidates for elective cesarean section under spinal anesthesia; classified as Physical Status II to III by the American Society of Anesthesiologists (ASA); who sign the Informed Consent Form	Hypertensive disease of pregnancy; pre-existing arterial hypertension (blood pressure greather than 140/90); twin pregnancy; known cerebrovascular or cardiovascular disease; suspected or confirmed congenital malformation or fetal distress; active labor; emergency cesarean section; any contraindication to spinal anesthesia; refusal to participate in the study; and spinal anesthesia failure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:11
RBR-10v9xqcw	Exercise with and without blood flow restriction: what changes in the blood pressure of women with hypertension	Recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8495	The influence of Acute Aerobic Exercise with and without blood flow restriction and Genetic Polymorphisms on blood pressure in hypertensive women	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-14	Universidade Federal da Paraíba	<NULL>	<NULL>	<NULL>	Be female; be between forty-five and sixty-five years old; have controlled stage one hypertension according to the Brazilian Society of Cardiology classification (2020), with systolic blood pressure between one hundred and forty and one hundred and fifty-nine millimeters of mercury and diastolic blood pressure between ninety and ninety-nine millimeters of mercury, or use continuous antihypertensive medication; have a body mass index lower than thirty-five kilograms per square meter, corresponding at most to class one obesity; have no target organ damage or cardiorespiratory conditions that prevent exercise performance; be a non-smoker; not have diabetes mellitus, with fasting blood glucose lower than one hundred milligrams per deciliter; ankle-brachial index between zero point ninety and one point forty; be physically active according to the International Physical Activity Questionnaire short version; have no cardiopulmonary problems such as unstable angina, acute myocardial infarction, uncontrolled arrhythmia, severe aortic stenosis, decompensated heart failure, acute pulmonary embolism, pulmonary infarction, venous thrombosis, acute myocarditis or pericarditis; not use medications that significantly affect heart rate, such as beta-blockers atenolol, propranolol and metoprolol; not have renal failure with creatinine greater than one point five milligrams per deciliter; voluntarily agree to participate by signing the Informed Consent Form	Participants who present during the experiment any cardiovascular or musculoskeletal aggravation that prevents the continuation of exercise practice; withdraw from the study; show an increase in dosage or change in the class of medication during the observation period	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:12
RBR-3s85fz4	Double conjunctival flap with suture versus conjunctival autograft with glue for primary pterygium: a prospective, randomized study	Not yet recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8496	Conjunctival autotransplantation with glue versus double flap with suture for primary pterygium. Interventional study	<NULL>	2, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-20	Hospital Universitário da Universidade Federal do Maranhão/HU/UFMA	<NULL>	<NULL>	<NULL>	The inclusion criteria will be patients aged over 18 and under 80 years; without the occurrence of ocular surface disease, including dry eye and blepharitis, and with availability for clinical follow-up for at least six months after surgery. This information will be collected during ophthalmological consultations. To eliminate duplication bias when using both eyes from the same patient, only the first operated eye will be included in the analysis.	Exclusion criteria will include patients under 18 or over 80 years of age; presence of symblepharon; cicatricial conjunctival diseases; glaucoma; ocular allergy; recurrent pterygium in the ipsilateral eye, and those who do not sign the Free and Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:13
RBR-3vqhv5d	Effects of a training program involving vascular Occlusion and Jumping on the functionality of elderly people	Not yet recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8497	Effects of a training program involving Ischemic Preconditioning and Jumps on the functionality and power of the lower limbs of elderly individuals: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-05	Universidade São Judas Tadeu	<NULL>	<NULL>	<NULL>	Individuals of both sexes will be included; aged ≥ 60 years and &lt; 71 years; who are available to participate in the intervention program at least three times a week for 12 weeks	Participants with the following clinical conditions will be excluded: recent acute myocardial infarction or unstable angina; uncontrolled atrial or ventricular arrhythmias; dissecting aortic aneurysm; severe aortic stenosis; acute endocarditis or pericarditis; uncontrolled arterial hypertension; acute thromboembolic disease; severe acute heart failure; severe acute respiratory failure; uncontrolled orthostatic hypotension; diabetes mellitus with acute decompensation or uncontrolled hypoglycemia; recent fracture (in the last month); or any other medical condition that prevents the performance of the physical activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:14
RBR-77f8rjq	Effects of the combination of Electrical Stimulation and Exercise on pain, strength, and mobility in people with knee Osteoarthritis	Not yet recruiting	Intervention	2025-11-05	<NULL>	<NULL>	8498	Effects of adding Neuromuscular Electrical Stimulation to Resistance Exercise on pain, self-reported physical function, muscle torque, and performance-based physical function in patients with knee Osteoarthritis: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-30	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	<NULL>	<NULL>	<NULL>	Participants with a diagnosis of knee osteoarthritis according to the clinical criteria of the American College of Rheumatology; aged 18 years or older; no gender restrictions	Secondary knee osteoarthritis (e.g., septic arthritis, inflammatory joint disease, gout, articular fracture, severe dysplasias, congenital abnormalities, or hemochromatosis); systemic arthritic conditions; history of arthroplasty or other surgical interventions in the knee or hip; associated neurological diseases that impair lower limb function (such as post-stroke, neuropathies, or multiple sclerosis); contraindications and precautions related to neuromuscular electrical stimulation, including patients with pacemakers or cardiac defibrillators, deep vein thrombosis, areas with diagnosed or suspected malignancies, active bleeding, infection, skin disease, areas with impaired sensation, or pregnancy; intra-articular corticosteroid injection within the past three month	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:21:42
RBR-4qrd3qt	Nutrition, routine examinations, and physical tests for youth soccer players	Not yet recruiting	Intervention	2025-11-04	<NULL>	<NULL>	8499	Nutritional status, biomarkers, and performance indicators of youth soccer players	<NULL>	n/a, non-randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Federal de Jataí	<NULL>	<NULL>	<NULL>	Male athletes; aged between 14 and 20; registered with soccer federations; fit to participate in sports activities during the collection period	Foreign athletes; individuals with less than two years of federation membership; athletes sidelined due to musculoskeletal injuries; athletes medically unfit for a period of six months or longer	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:16
RBR-7fhkrgz	Analysis of Root Apex Healing and Postoperative Pain in Root Canal Treatment of Posterior Teeth with Apical Preparation Performed Using Different Instrument Diameters	Recruitment completed	Intervention	2025-11-04	<NULL>	<NULL>	8500	Analysis of Periapical Healing and Postoperative Pain in Endodontic Treatment of Molar Teeth with Chronic Apical Periodontitis Using Different Apical Preparation Diameters: A Randomized Clinical Tria	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-02	Faculdade de odontologia da universidade federal do amazonas	<NULL>	<NULL>	<NULL>	Adult competent patients between 18 and 65 years old; diagnosed with chronic apical periodontitis in molar teeth; who have a telephone for contact; and who agree to the terms of the study.	Pregnant patients; patients diagnosed with type I or type II diabetes; patients with hypersensitivity to anti-inflammatory drugs or analgesics; patients without a telephone for contact; patients with root alterations or dental conditions that prevent endodontic treatment; patients who, for any reason, cannot undergo single-session treatment.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:19
RBR-27sf3w5	Effects of a Multiprofessional Intervention on the Health of Elderly Individuals After COVID-19	Not yet recruiting	Intervention	2025-11-04	<NULL>	<NULL>	8501	Effects of a Multiprofessional Intervention on Health-Related Physical Fitness, Nutritional Profile, and Mental Health of Elderly People Post-Covid-19 According to Nutritional Status: A Clinical Trial	<NULL>	n/a, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-11	Universidade Unicesumar	<NULL>	<NULL>	<NULL>	Older adults of both sexes aged between 60 and 79 years, with persistent post-COVID-19 symptoms or without a history of COVID-19 infection, who are physically able to perform moderate to vigorous intensity physical exercise and available to regularly participate in the project activities will be included	Participants with debilitating neurological diseases such as Alzheimer’s disease; Parkinson’s disease, or plegias; or those with reduced intellectual capacity; will not be eligible for this study. Individuals currently using corticosteroids or with chronic or acute conditions that contraindicate physical exercise or may alter the response to the intervention will be excluded. Participants with disabling atherosclerotic disease, class 4 congestive heart failure, active rheumatoid arthritis, advanced renal or hepatic disease, undergoing chemotherapy for cancer, or other similar conditions will also be excluded. Finally, participants who attend less than 85% of the intervention sessions will not be considered	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:20
RBR-3g8vcjs	Treatment of Neurogenic Detrusor Dysfunction by Photobiomodulation	Recruiting	Intervention	2025-11-04	<NULL>	<NULL>	8502	Treatment of Neurogenic Detrusor Dysfunction by Photobiomodulation	<NULL>	n/a, single-arm-study, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-01	Sociedade Educacional ltda - Universidade Anhembi Morumbi	<NULL>	<NULL>	<NULL>	The protocol includes adults; young children (1-5 years) and young people in the school-age range (5-16 years) of both genders, with congenital or acquired pathologies of the lower urinary tract, determining factors of impaired bladder storage or emptying capacity, confirmed through clinical evaluation and urodynamic parameters	Adults with bladder, gynecological, or gastrointestinal tract cancer, as well as pregnant women. Children under one year of age who are indicated for lower urinary tract surgery and have not yet undergone the procedure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:22
RBR-63jtrzs	Impact of macro-geometry on the initial bone repair process and primary stability of dental implants	Data analysis completed	Intervention	2025-11-03	<NULL>	<NULL>	8503	Impact of macro-geometry on the initial bone repair process and primary stability of dental implants: A prospective, controlled, randomized, split-mouth clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-02-04	Associação Unificada Paulista de Ensino Renovado Objetivo	<NULL>	<NULL>	<NULL>	Patient aged between 18 and 75 years, of both sexs, with total edentulism of the mandible and/or maxilla; patients with sufficient bone volume and height for implant placement	Use of antibiotics; continuous-use anti-inflammatories; phenytoin; cyclosporine; bisphosphonates in the 6 months prior to the study; presence of systemic changes or active infectious disease (diabetes, heart disease, hepatitis, etc.); smoking; pregnancy; breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:23
RBR-7czcv5v	The effects of a Mindfulness-Directed Physical Exercise Protocol on individuals over 50 years of age	Recruitment completed	Intervention	2025-11-01	<NULL>	<NULL>	8473	Evaluation of the effects of a mindfulness-directed Physical Exercise Protocol on health biomarkers in individual over 50 years of age: a randomized controlled crossover clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Sociedade de Educação Superior e Cultura Brasil S.A.	<NULL>	<NULL>	<NULL>	Individuals aged 50 years or older; both sexes; capable of providing informed consent; not currently using similar therapies and with a baseline level of physical activity (sedentary or moderately active); must have stable and well-controlled chronic conditions; willingness to comply with the study protocol; absence of recent surgeries or serious injuries (within the last 6 months); not participating in other interventional studies	Having cardiac pacemakers or other implanted medical devices; severe musculoskeletal disorders; severe cardiovascular conditions; diagnosed neurological conditions; severe cognitive impairment; uncontrolled medical conditions; severe respiratory conditions; current substance abuse; pregnancy; diagnosis of severe psychiatric disorders; current use of medications that significantly affect Heart Rate Variability (HRV) or body composition; recent use of fascia-targeted therapies (within the last 3 months)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:24
RBR-88k7mvw	Effect of topical application of 10% Silver Nitrate solucion versus 10% Potassium Hydroxide in the treatment of Molluscum Contagium	Not yet recruiting	Intervention	2025-11-01	<NULL>	<NULL>	8474	Efficacy and safety of topical application of 10% Silver Nitrate solucion versus 10% Potassium Hydroxide in the treatment of Molluscum Contagium	<NULL>	3, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Patients with a clinical diagnosis of molluscum contagiosum, without perimolluscal eczema; aged between one and twelve years; of both sexes; whose parents or legal guardians have signed an informed consent form	Individuals with congenital or acquired immunosuppression; children who have used another treatment in the last month; patients with lesions on the face or genital region; children with allergies to the components of the medications	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:25
RBR-7xv3cdz	CRISCO study: lifestyle and health of adolescents from the Federal District	Recruiting	Observational	2025-10-31	<NULL>	<NULL>	8475	CRISCO study: health risk behaviors in adolescents in the Federal District	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Programa de Pós-graduação Stricto Sensu em Educação Física da Universidade Católica de Brasília - PPGEF-UCB	<NULL>	<NULL>	<NULL>	Students of both sexes; aged between 14 and 19 years; regularly enrolled in the integrated technical high school programs at the Federal Institute of Brasília (IFB); presentation of the Informed Consent Form signed by parents or guardians for those under 18 years old, or by the adolescents themselves for those aged 18 or 19; and presentation of the Assent Form signed by adolescents under 18 years old	Physical and/or mental conditions that compromise safe participation, such as inability to understand or respond to questionnaires, severely reduced mobility; pregnant adolescents; absence on assessment days (resulting in incomplete data); and voluntary withdrawal	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:27
RBR-9qb8wsx	The effectiveness of Educational Initiatives on sexual abuse awareness among adolescents in public schools	Data analysis completed	Intervention	2025-10-31	<NULL>	<NULL>	8476	The impact of Educational Actions on knowledge of sexual abuse among adolescents in public schools	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Medicina de Jundiaí	<NULL>	<NULL>	<NULL>	Adolescents aged 15 to 19 years; students from the selected school; male and female	Not being a student in the second year at school	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:27
RBR-4s4jv7v	Clinical evaluation of tooth whitening with violet light	Recruiting	Intervention	2025-10-31	<NULL>	<NULL>	8477	Long-term clinical evaluation in-office dental bleaching using violet LED light (405-410 nm)	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-22	Faculdade de Odontologia da Universidade de São Paulo (Fousp)	<NULL>	<NULL>	<NULL>	Minimum age of 18 years and maximum age of 30 years; presence of all dental elements, without aesthetic restorations or caries lesions in the upper and lower anterior teeth; and participants with canine tooth color of A3 or darker, according to the VITA® Classical Color Scale	Presence of any type of systemic pathology; presence of periodontal disease; systematic use of tobacco and alcoholic beverages; participants with teeth discolored by tetracycline, fluorosis, endodontic treatment; participants with a history of self-reported tooth sensitivity; pregnant or breastfeeding female participants; presence of crowns or restorations on the anterior teeth (15 to 25 and 35 to 45); and participants with bruxism or undergoing treatment with medication with anti-inflammatory, analgesic and/or antioxidant action	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:29
RBR-10vqn68h	Nutritional Supplements: Understanding the Responses in Strength and Endurance Training	Not yet recruiting	Intervention	2025-10-31	<NULL>	<NULL>	8478	Nutritional supplements and responses to different physical activity programs	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-10	Universidade Federal de Lavras	<NULL>	<NULL>	<NULL>	Male individuals who regularly practice physical activity; Age between 18 and 35 years; Regular practice of physical activity for at least 24 months	Smoker; Patients with diabetes and/or cardiovascular diseases; History of osteoarticular injury in the last six months. Use of any ergogenic resource and / or dietary supplement; Failure to attend LEMOH or the Sports Nutrition Laboratory on the days of tests	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:29
RBR-8kqnzkt	Bioactive composite resin in gingival recession treatment: Randomized clinical study	Recruitment completed	Intervention	2025-10-31	<NULL>	<NULL>	8479	Evaluation of a bioactive composite resin in the surgical/restorative treatment of gingival recessions in non-carious cervical lesions: A randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade de Guarulhos (UnG)	<NULL>	<NULL>	<NULL>	Systemically healthy individuals; age between 18 and 50 years; at least two teeth with gingival recessions Recession Type 1 or Recession Type 2 (Miller Class I or II); presence of non-carious cervical lesions associated with gingival recessions located in upper canines or premolars; periodontally healthy patients with less than 10% of sites presenting bleeding on probing and probing depth less than or equal to 3 mm	Smokers; pregnant or lactating women; individuals with diabetes or periodontal disease with more than 10% of sites showing bleeding on probing; teeth positioned buccally outside the alveolar envelope; continuous use of anti-inflammatory drugs or medications that interfere with tissue response such as anticoagulants, antiplatelet agents, phenytoin and calcium channel blockers; patients allergic to iodine or with known hypersensitivity to the materials used; contraindications for periodontal surgery	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:29
RBR-6m2hb8h	Evaluation of the cardioprotective effects of Dapagliflozin in patients with Sickle Cell Disease	Not yet recruiting	Intervention	2025-10-30	<NULL>	<NULL>	8480	Use of Dapagliflozin in adults patientes with Sickle Cell Disease	<NULL>	2, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2027-01-01	Centro de Hematologia e Hemoterapia da Unicamp – Hemocentro da UNICAMP	<NULL>	<NULL>	<NULL>	Adults aged 18 years or older; both sexes; confirmed diagnosis of sickle cell disease (homozygous sickle cell anemia SS or compound heterozygous SB); signed Informed Consent Form (ICF)	Pregnancy; severe liver failure; current use of sodium-glucose cotransporter 2 inhibitor (SGLT2i)	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:31
RBR-8k9xz7z	The use of Laser in the treatment of muscle weakness in the elderly	Recruiting	Intervention	2025-10-30	<NULL>	<NULL>	8481	Use of Transcutaneous Vascular Photobiomodulation for improving muscle strength and function in frail elderly individuals	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-04	Universidade São Francisco-SP	<NULL>	<NULL>	<NULL>	Men and women; aged 60 to 80 years; with a score greater than 4 on the Sarcopenia Screening Tool (SARC-F) questionnaire	Musculoskeletal and cardiorespiratory dysfunctions; volunteers who experience disabling pain while performing the exercises and dynamometry tests	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:32
RBR-87ymt3c	Effects of Pilates training on hypertensive women taking medication	Recruitment completed	Intervention	2025-10-30	<NULL>	<NULL>	8482	Effects of the Pilates Method on hemodynamic, autonomic, endothelial and psychobiological mechanisms of medicated Hypertensive women	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de São Paulo	<NULL>	<NULL>	<NULL>	Women with hypertension on medication; between 30 and 59 years of age; sedentary; with a body mass index of up to 30 kilos per square meter; not using contraceptives or taking hormone replacement therapy; with medical clearance to practice physical exercise; without osteomyoarticular disease that could compromise the partial or total execution of the proposed exercises; without another disease that could compromise the cardiovascular, respiratory, or metabolic response to exercise; without diabetes mellitus; non-smokers and non-alcoholics; without target organ damage, such as nephropathy, heart disease, etc.; and who agree to be a volunteer for the project	Women with medication changes during the trial period, such as class and dose; with a frequency of less than 75% in training sessions	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:33
RBR-8zhtrv4	Feasibility study of transcranial direct current stimulation (tDCS) efficacy in patients with neurogenic dysphagia	Not yet recruiting	Intervention	2025-10-30	<NULL>	<NULL>	8483	Non-invasive brain stimulation in neurological conditions	<NULL>	n/a, single-arm-study, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Centro de Ciências da Saúde	<NULL>	<NULL>	<NULL>	Eligibility criteria include adults (≥18 years) with a confirmed neurological diagnosis and clinical signs or symptoms of swallowing disorders	Patients receiving alternative feeding methods (e.g., enteral tube feeding or gastrostomy) and those with intracranial metallic implants or cardiac pacemakers will be excluded	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:34
RBR-82fjc5f	Randomized controlled clinical trial evaluating a complementary Spiritual Intervention adjunctive to conventional psychiatric inpatient treatment	Not yet recruiting	Intervention	2025-10-30	<NULL>	<NULL>	8484	Effectiveness of a complementary Spiritual Intervention to conventional psychiatric treatment in hospitalized patients with suicidal behavior: an observational intervention study	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2026-01-01	Faculdade de Medicina da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Adult patients admitted to a psychiatric inpatient unit	Significant cognitive disorganization that prevents the participant from understanding and adequately responding to the questionnaires used for data collection	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:35
RBR-6d3g5hp	Assessing Mineral Gain of a Remineralizing Toothpaste in Teeth with Molar Incisor Hypomineralization (MIH)	Recruitment completed	Intervention	2025-10-30	<NULL>	<NULL>	8485	Evaluation of the remineralizing effect of a Silicon-Enriched Toothpaste on teeth with Molar Incisor Hypomineralization (MIH): a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-20	Universidade Federal de Minas Gerais	<NULL>	<NULL>	<NULL>	Children aged 6-12 years; with fully erupted permanent central and lateral incisors; with MIH lesions of any severity level diagnosed by a trained dentist according to the criteria established by Ghanim et al. (2017).	Children with syndromes; children undergoing orthodontic treatment with fixed appliances; previously restored or treated permanent incisors; presence of other enamel defects such as dental fluorosis/hypoplasia.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:35
RBR-6srbb6p	Fenugreek extract topical gel to treat scally skin disease	Recruitment completed	Intervention	2025-10-30	<NULL>	<NULL>	8486	Clinical and biochemical impact of fenugreek (trigonella foenum  graecum) seeds on Insulin resistance in psoriatic patients visiting tertiary care hospitals of Rawalpindi	<NULL>	2, non-randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-04	National University of Medical Sciences Rawalpindi Pakistan	<NULL>	<NULL>	<NULL>	Inclusion Criteria, Psoriatic patients;Age between 18 and 65 years; males and females; both diabetic and non-diabetic psoriatic patients	History of alcohol abuse; prior or current use of hepatotoxic medications; any known liver disease; Individuals with clinical evidence of acute hepatitis or positive hepatitis B surface antigen (HBsAg); pregnant or lactating women; individuals with known allergy to fenugreek	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:38
RBR-4jhsqvg	Photobiomodulation therapy combined with Fibrin-Rich Plasma and Leukocytes for the preservation of alveolar bone height after tooth extractions	Recruiting	Intervention	2025-10-30	<NULL>	<NULL>	8487	Photobiomodulation therapy combined with Fibrin-Rich Plasma and leukocytes for the preservation of alveolar bone height. A randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-20	Faculdade de Odontologia da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Participants in good systemic health; age 18 to 80 years; all genders patients; patients who are indicated for extraction of at least one permanent lower posterior tooth (molars or premolars); patients who agree to participate in the protocol and its postoperative follow-up periods	Oral soft or hard tissue tumors; advanced periodontal disease (suppuration, exudate, tooth mobility, severe bone loss); systemic disease; smokers or alcoholics; pregnant or lactating; use of any medications that may interfere with the study results; participants with photophobia or any medical condition that contraindicates the use of oral laser	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:39
RBR-2b4t4y2	Efeitos da Eletroestimulação Auricular Vagal em Fibromialgia	Not yet recruiting	Intervention	2025-10-29	<NULL>	<NULL>	8470	Effects of transcutaneous auricular vagal electrical stimulation in individuals with fibromyalgia: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-03	Universidade Estadual da Paraíba	<NULL>	<NULL>	<NULL>	Women; aged between 18 and 70 years; with a diagnosis of fibromyalgia (the diagnosis will be made by a physician referred by the patient and confirmed by a physical therapist with experience in rheumatology), taking into account the diagnostic criteria for fibromyalgia from the American College of Rheumatology.	Participants who are pregnant, have a history of epilepsy, have a metal implant, have undergone neurosurgery, have a psychiatric illness such as schizophrenia and bipolar disorder, otitis, and those with cognitive impairment expressed with difficulty in speaking and/or understanding and visual deficit that prevent the completion of the scales.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:39
RBR-9cd8997	Pain Relief in Fibromyalgia with Magnesium and Amitriptyline	Recruiting	Intervention	2025-10-29	<NULL>	<NULL>	8471	Comparative Study of Pain Relief with the Combination of Magnesium and Amitriptyline in Patients with Fibromyalgia	<NULL>	2, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de São Paulo (UNIFESP)	<NULL>	<NULL>	<NULL>	Age over eighteen years; diagnosis of Fibromyalgia obtained using the Fibromyalgia Survey Questionnaire FSQ – Brazil; pain intensity greater than or equal to four.	Other documented or suspected causes of pain; use of illicit drugs; pregnant women; previous or current treatment with dietary supplements containing Magnesium; concurrent inclusion in another interventional study; inability to understand the information provided to participants or to sign the Informed Consent Form; use of medications such as calcitonin, glucagon, potassium-sparing diuretics, fluoroquinolones, aminoglycosides, bisphosphonates, calcium channel blockers, tetracyclines, or muscle relaxants; renal insufficiency.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:40
RBR-6pbpwpm	Study on sending text messages to help pregnant women with Syphilis follow treatment correctly	Not yet recruiting	Intervention	2025-10-29	<NULL>	<NULL>	8472	Use of short messages through mobile messaging applications to improve adherence to Syphilis treatment during pregnancy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-17	Centro Universitário Norte do Espírito Santo – Universidade Federal do Espírito Santo (UFES)	<NULL>	<NULL>	<NULL>	Pregnant women diagnosed with syphilis infection during pregnancy; before starting treatment or shortly after the first dose of benzathine penicillin; age 18 years or older; reside in the study area; have access to a mobile phone capable of receiving and sending text messages; willing to be followed up for up to six weeks after delivery	Pregnant women who have already completed syphilis treatment in the current pregnancy; pregnant women unable to communicate via text messaging; pregnant women who do not agree to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:41
RBR-4rg8b8p	How Respiratory Muscle Training can improve care in the Intensive Treatment Units of the Unified Health System	Recruiting	Intervention	2025-10-28	<NULL>	<NULL>	8462	Impact of Respiratory Muscle Training in the ICU for strengthening assistance in the Unified Health System	<NULL>	n/a, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Estadual de Goiás	<NULL>	<NULL>	<NULL>	Age 18 years or older; both sexes; hemodynamically stable; using an artificial airway device (orotracheal tube or tracheostomy); on mechanical ventilation with ventilatory parameters favorable for the initiation of the weaning process (PSV mode)	Participants with any type of neuromuscular disease; with contraindications to respiratory exercise for respiratory muscle training; dependent on controlled modes of mechanical ventilation; and under deep sedation	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:42
RBR-6mp5qvc	Evaluation and comparison of the efficacy of bone marrow-derived products in the treatment of osteoarthritis	Recruitment completed	Intervention	2025-10-28	<NULL>	<NULL>	8463	Evaluation and comparison of the efficacy of autologous Bone Marrow-derived Products (BMA and BMAC) in the treatment of Osteoarthritis of the hip, knee and spine	<NULL>	n/a, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-02-10	Instituto de Ensino Superior de Indaiatuba LTDA	<NULL>	<NULL>	<NULL>	Both sexes; aged between 30 and 80 years; and having diagnosed osteoarthritis and classified according to an X-ray report; patients with moderate to severe osteoarthritis (III and IV)	Presenting osteoathritis of another origin and/or another degree according to the classifications mentioned above; presenting systemic diseases such as diabetes; rheumatoid arthritis; axial deviation (varus higher than 5 degrees, valgus higher than 5 degrees); hematologic diseases; cardiovascular diseases; infections; and immunosuppression; patients undergoing anticoagulant or antiplatelet therapy; use of nonsteroidal anti-inflammatory drugs 5 days before each blood collection; and patients with a hemoglobin concentration below 11 mg/dL and platelet count below 150,000 mm³	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:43
RBR-8zfdnd4	Psychomotor stimulation through musical practice using the Orff approach in children for the development of  spatial and temporal perception	Not yet recruiting	Intervention	2025-10-28	<NULL>	<NULL>	8464	Psychomotor stimulation focused on spatio-temporal structuring and Orff practice randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Federal de Alfenas UNIFALMG	<NULL>	<NULL>	<NULL>	Children enrolled in school in the school year/grade (4 and 5 years old); children whose parents agree to participate and sign the informed consent form.	Children who do not have physical or mental disabilities; children who did not participate in extracurricular activities such as swimming, martial arts, and ballet; children with orthopedic injuries that prevent them from performing psychomotor activities; children who are not enrolled in the Diadema Municipal Basic Education School.	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:43
RBR-72ds2kn	Study of a new technology for the treatment of Cerebral Aneurysms	Recruiting	Intervention	2025-10-28	<NULL>	<NULL>	8465	Pilot prospective study evaluating Derivo2-heal Flow Modulators in the treatment of Cerebral Aneurysms	<NULL>	2-3, non-randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Patients aged 18 to 80 years inclusive; Patients of any gender; Patients with an unruptured aneurysm; Saccular or fusiform aneurysm located in the right internal carotid artery; Patients who agree to and sign the informed consent form; Patient correctly using antiplatelet therapy	Any ischemic or hemorrhagic stroke within the past 90 days; Ruptured aneurysm within the past 90 days; Previous modified Rankin Scale (mRS) &gt; 2; Major surgery requiring general anesthesia within the past 90 days; Known coagulation disorder; Use of anticoagulants (warfarin, dabigatran, etc.); Platelet count &lt; 100,000 cells/mm³ or known platelet dysfunction; Contraindication to the study medications (heparin, aspirin, prasugrel); Presence of a previously placed neurostent adjacent to the aneurysm to be treated; Presence of a previously placed surgical clip adjacent to the aneurysm to be treated, causing any degree of carotid artery stenosis; Known severe allergy to iodinated contrast agents (defined by prior occurrence of bronchospasm, laryngospasm, or circulatory shock); Chronic kidney disease (defined by serum creatinine &gt; 2.5 mg/dL); Pregnancy, breastfeeding, or a positive pregnancy test; Any other medical condition resulting in a life expectancy of ≤ 12 months	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:45
RBR-42hbfwp	Chronic Neck Pain Study using Exercises and Magnetic Stimulation	Recruiting	Intervention	2025-10-28	<NULL>	<NULL>	8466	Effects of Neuromodulation and a Therapeutic Exercise Intervention on Chronic Cervical Pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, n/a	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-21	Universidade de São Paulo	<NULL>	<NULL>	<NULL>	Individuals of both sexes; clinical diagnosis of chronic neck pain defined as persistent pain in the cervical region for more than 12 weeks; pain intensity equal to or greater than 3 points on the Visual Numerical Scale (VNS) at the time of screening; able to perform therapeutic exercises and repetitive peripheral magnetic stimulation (rPMS) sessions; signed Informed Consent Form approved by the Research Ethics Committee	Diagnosis of specific cervical pain of severe structural origin such as herniated disc with root compression; symptomatic spinal stenosis; vertebral fractures; cervical spine tumors; cervical surgery or invasive procedures (infiltration or nerve block) within the last six months; presence of metallic implants or pacemaker in the cervical region contraindicating the use of rPMS; degenerative neurological diseases (e.g., multiple sclerosis, severe peripheral neuropathies); active inflammatory rheumatic diseases (rheumatoid arthritis); skin hypersensitivity; cognitive impairment; other decompensated neurological and systemic pathologies; mandibular and/or palatal torus; undergoing orthodontic, speech therapy, or otorhinolaryngological treatment; continuous or prolonged use of anti-inflammatory medications due to potential interference with pain and inflammation outcomes evaluated in the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:46
RBR-5fdrm8b	The effect of Low Level Laser on Reducing Pain and Healing of Nipple Injuries in breastfeeding women	Recruiting	Intervention	2025-10-28	<NULL>	<NULL>	8467	Effectiveness of Photobiomodulation in Pain Reduction and Tissue Repair of Nipple Injuries in breastfeeding women (LaserMamy): A multicenter, randomized, factorial clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-19	Escola Paulista de Enfermagem	<NULL>	<NULL>	<NULL>	Women with age equal to or greater than 18 years; Who are breastfeeding the child; Who present unilateral or bilateral nipple lesion; Who report three or more points of nipple pain during breastfeeding according to the Numeric Rating Scale (NRS 0 to 10); With a single full-term newborn (equal to or greater than 37 weeks of gestation); With newborn weight equal to or greater than 2500 grams; Speak and read Portuguese	Women with photosensitivity or any adverse reactions to laser light exposure	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:47
RBR-32f2k7r	CALLY Index and Its Relationship with Ulcerative Colitis Activation: Could It Be a New Evaluation Parameter?	Terminated	Observational	2025-10-28	<NULL>	<NULL>	8468	CALLY Index and Its Relationship with Ulcerative Colitis Activation: Could It Be a New Evaluation Parameter?	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-06-01	Akdeniz University	<NULL>	<NULL>	<NULL>	Patients diagnosed with active Ulcerative Colitis admitted to the hospital between June 2020 and December 2024; availability of complete medical history, laboratory parameters, and colonoscopic findings in the patient files; individuals considered as healthy controls for comparison purposes	Patients diagnosed with Ulcerative Colitis admitted outside the specified study period (June 2020 to December 2024); patients with incomplete medical history or missing data on disease activity, colonoscopic findings, or laboratory parameters; patients with concurrent diagnoses of other inflammatory bowel diseases (e.g., Crohn&apos;s Disease); patients with a history of colectomy; healthy controls with any active inflammatory disease or chronic systemic condition	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:47
RBR-10kbdt3j	Influence of different combined training protocols on EPOC	Recruiting	Observational	2025-10-28	<NULL>	<NULL>	8469	Influence of different concurrent training protocols on excess post-exercise oxygen consumption (EPOC)	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-06	Instituto Federal de Educação, Ciência e Tecnologia do sul de Minas Gerais	<NULL>	<NULL>	<NULL>	male sex; age between 18 and 35 years; physically active for at least 3 months prior to the beginning of the study; no chronic diseases or disabling conditions for the proposed tests; signed the Informed Consent Form; answered no to all questions on the Physical Activity Readiness Questionnaire	failure to perform or complete one or more of the proposed protocols, regardless of the stage in the intervention process; showing disrespect to any member of the research team; presenting any health problem that prevents the execution of tests or participation in the intervention; at any time, regardless of the reason, expressing the desire to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>	2026-05-11 05:22:48
RBR-3qfxtvt	Reduction of fasting time in Breast Cancer surgeries in a military hospital: a test to implement a new Protocol	Recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8454	Fasting abbreviation in Breast Cancer surgeries: a pilot for the implementation of the Acerto protocol	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Hospital Central do Exército	Instituto de Nutrição Josué de Castro/ Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3qfxtvt	<NULL>	Woman from 18 years old; with indication of elective surgery for treatment of breast cancer.	Women with severe gastroesophageal reflux; chronically uncompensated diabetes mellitus; megaesophagus; esophageal and/or intestinal obstruction; gastroparesis; pyloric stenosis and patients with previous gastrointestinal surgery with compromised gastric emptying.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-5x5yy7w	How strength training with controlled speed compares to traditional training in the elderly: impacts on muscles and functions	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8455	Effects of velocity-based strength training compared to traditional strength training on neuromuscular and functional parameters in older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-20	Universidade Comunitária Da Região De Chapecó	Universidade Comunitária Da Região De Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-5x5yy7w	<NULL>	Elderly individuals of both sexes; aged between 60 and 70 years	People with clinical or motor restrictions preventing physical exercise; who have participated in systematic strength training programs in the two months prior to this study; participants who miss a total of three training sessions or two consecutive sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-54z4k5x	Teaching in the care of patients with long-term left ventricular assist devices	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8456	Teaching strategies for the learning process of care for patients with long-term left ventricular assistive device	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-14	Faculdade de Medicina da Universidade de São Paulo	Hospital Do Coração/Associação Beneficente Síria - HCOR	https://ensaiosclinicos.gov.br/rg/RBR-54z4k5x	<NULL>	Doctors and nurses enrolled in the e-learning and in-person sessions of the course	professionals who refuse to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-2x9sjks	Study on the effects of infrared light on memory, attention and concentration in healthy young adults	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8457	The cognitive effects of LASER Photobiomodulation Therapy in healthy subjects: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2026-03-02	Sociedade de Educação Superior e Cultura Brasil S.A.	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2x9sjks	<NULL>	Be a regular student of the medical course at the University of Southern Santa Catarina UNISUL; of both sexes; be between 18 and 25 years old	Failure to sign the Free and Informed Consent Form FICF; have a history of or present epileptic episodes; use psychiatric medication; be pregnant or breastfeeding; be an oncology patient	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-57mfyb3	Use of portable laser on surgical wounds immediately after surgery	Recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8458	Use of low-intensity laser in sutured surgical wounds in the immediate postoperative period	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-03-01	Fundação José Bonifácio Lafayette Andrada	Fundação José Bonifácio Lafayette Andrada	https://ensaiosclinicos.gov.br/rg/RBR-57mfyb3	<NULL>	Patients with sutured wounds in the immediate postoperative period of plastic surgery; aged between 20 and 60 years, undergoing primary or secondary surgeries	Patients using photosensitizing medications (such as isotretinoin and corticosteroids)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-10kvqs94	Hydrotherapy and perineal massage for chronic pelvic pain due to Endometriosis	Recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8459	Effectiveness of hydrotherapy and perineal massage in chronic pelvic pain associated with Endometriosis compared with conventional medical treatment: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-12	Departamento de Fisioterapia	Departamento de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-10kvqs94	<NULL>	Age range from 18 to 45 years; radiological diagnosis of endometriosis (ultrasound or magnetic resonance imaging) determined by a specialist physician; pelvic pain and dyspareunia score greater than 4 on the Visual Analogue Scale; undergoing conventional medical treatment	Virginity; pregnancy; postpartum period less than or equal to six months; neurological, rheumatic, or degenerative diseases; history of fracture and/or neoplasm in the spine or pelvis; physical therapy treatment in the last three months; pelvic pain of another nature (such as acute pelvic inflammatory disease, interstitial cystitis, ulcerative colitis, etc.); chlorine allergy; anxiety conditions related to water; severe cardiovascular disease; heat intolerance; active infectious disease; open wounds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-10438p9q	Exercise program, Walking and Balance Training with Shoes and Insole associated with Pain Education in older women with Plantar Fasciitis	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8460	Therapeutic effect of the intervention program with Exercise, Gait Retraining and Balance with Footwear and Insole associated with Education in Pain Neuroscience of elderly women with Plantar Fasciitis: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-24	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	https://ensaiosclinicos.gov.br/rg/RBR-10438p9q	<NULL>	Women; aged between 60 and 80 years; body mass index (BMI) less than 35 kg/m²; walk independently for at least 6 hours a day; do not use orthoses to perform daily activities	History of knee, ankle, or hip surgery in the last 6 months; muscle injury in the last 6 months; diagnosed neurological disease; diagnosed rheumatological disease; leg length discrepancy greater than 1 cm; presence of hallux rigidus; indication for fasciotomy; presence of arthroplasty or indication for arthroplasty during the intervention period; use of lower limb orthoses; corticosteroid injection in the heel in the last 3 to 6 months; ankle joint instability; dementia or inability to provide consistent information; use of minimalist flexible footwear or similar shoes for more than 25 hours per week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9s9hc29	The effect of the anesthetic Clonidine combined with Bupivacaine for pain control in patients who underwent Vitrectomy surgery	Not yet recruiting	Intervention	2025-10-27	<NULL>	<NULL>	8461	Evaluation of the effect of Clonidine associated with Bupivacaine in peribulbar block for patients undergoing Vitrectomy	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-11-01	Hospital e Maternidade São Domingos	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-9s9hc29	<NULL>	Patients older than 18 years; American Society of Anesthesiologists - ASA physical status I, II or III; of both sexes; undergoing vitrectomy; after signing the Informed Consent Form	Patient refusal of the block; coagulopathy or use of anticoagulants; altered state of consciousness; non-cooperative patient; uncontrolled arterial hypertension; recent acute myocardial infarction (&lt;6 months); glaucoma; recent analgesic therapy (&lt;2 weeks); chronic use of clonidine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-6mwmgmb	Microneedling or Plasma Jet: which works better to treat Acne Scars on the face after pregnancy?!	Recruiting	Intervention	2025-10-24	<NULL>	<NULL>	8452	Comparison between Microneedling and Plasma Jet for the treatment of Post-Acne scars on the split face during the post-pregnancy period: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Departamento de Fisioterapia - Faculdade de Ciências da Saúde do Trairí - Universidade Federal do Rio Grande do Norte - UFRN/FACISA	Faculdade de Ciências da Saúde do Trairí - Universidade Federal do Rio Grande do Norte - UFRN/FACISA	https://ensaiosclinicos.gov.br/rg/RBR-6mwmgmb	<NULL>	Women who have post-pregnancy acne scars; Between 18 and 35 years old; Date of last birth more than six months ago; Not being lactating; Women who agree to participate in the research, agreeing to sign the Free and Informed Consent Form (FICF)	Pregnant women; Dermatological changes such as: Solar keratosis, Warts, skin inflammation, Skin infections, Rosacea and acne in active phases; History of keloid and hypertrophic scars; Presence of neoplasia; Patients undergoing chemotherapy, radiotherapy; Uncontrolled diabetes mellitus; Patients using anticoagulants or corticosteroids; Use of oral isotretinoin with a break of less than six months; Sunburned skin; People with pacemakers and/or metal implants in the treatment area; Individuals with a history of epilepsy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-78cbsw2	Physiotherapeutic approach to superficial and deep Dyspareunia in women with Chronic Pelvic Pain: comparison Between in-Person and Telehealth care	Recruiting	Intervention	2025-10-24	<NULL>	<NULL>	8453	Physiotherapeutic approach to superficial and deep Dyspareunia in women with Chronic Pelvic Pain: comparison Between in-Person and Telehealth care. Randomized, prospective clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-23	Centro Saúde Escola Dr. Joel Domingos Machado - Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Centro Saúde Escola Dr. Joel Domingos Machado - Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78cbsw2	<NULL>	Women diagnosed with Chronic Pelvic Pain; Deep or shallow penetration dyspareunia; Over 18 years of age; Willingness to voluntarily participate in the study, accepting randomization to either of the two treatment arms; Signing of the Informed Consent Form	Women with penetrative dyspareunia without pelvic floor muscle spasm; Women without an active sex life; Women who have previously used medications that act on the central nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-6gs2ss2	Non-Surgical Periodontal Treatment associated with Oral Hygiene in ICU patients	Data analysis completed	Intervention	2025-10-23	<NULL>	<NULL>	8446	Non-Invasive Periodontal Treatment Protocol associated with Mechanical Control and Oral  Biofilm Chemistry in ICU patients	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2022-02-08	Christiane Mazurek Moraes	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6gs2ss2	<NULL>	Patients aged ≥18  who reported the presence of teeth;  Patients hospitalized in the ICUs of the Pedro Ernesto University Hospital; and  with the possibility of performing the periodontal examination and supragingival scaling in the first 48 hours in the intervention group	Edentulous patients;  Pregnant or breastfeeding patients;  Intubated patients (orotracheal tube); Patients with orthodontic;  Patients allergic to chlorhexidine; Patients with lung images that could interfere with the diagnosis of pneumonia;  Patients with suspected or diagnosed pneumonia; Patients with cardiac pacemakers; Patients undergoing interventions by Oral and Maxillofacial Surgery and/or Head and Neck Surgery which would make periodontal examination impossible and Patients with coagulation problems and others contraindicated by the medical team	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-6mwdg92	Clinical and radiological comparison of patients undergoing treatment for bone infection using standard treatment and the use of a product that replaces bone and can hold antibiotics	Recruiting	Intervention	2025-10-23	<NULL>	<NULL>	8447	Clinical and radiological comparison of patients undergoing surgical treatment of Osteomyelitis with conventional treatment and the use of synthetic graft with antibiotic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Ministerio da Saúde - Instituto Nacional de Traumatologia e Ortopedia/INTO	Hospital Estadual de Traumatologia e Ortopedia Dona Lindu	https://ensaiosclinicos.gov.br/rg/RBR-6mwdg92	<NULL>	Patients with osteomyelitis measuring up to 3 cm on radiograph; patients with soft tissue conditions for bone transport or compression-distraction surgery (traditional form of surgical treatment for osteomyelitis); presence of active fistula even with low secretion output	Presence of systemic signs of infection; lesions compatible with osteomyelitis in the metaphyseal region that make the installation of an external fixator unfeasible; tumor lesions; impossibility of standardized outpatient postoperative monitoring; pregnant patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-5kkspwk	Botulinum Toxin Injections for Men with Erectile Dysfunction	Recruiting	Intervention	2025-10-23	<NULL>	<NULL>	8449	Intracavernosal Botulinum Toxin Use in the Treatment of Erectile Dysfunction	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-03-01	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-5kkspwk	<NULL>	Having an International Index of Erectile Function – 5 items (IIEF-5) score of 21 points or less; being over 18 years of age; currently using at least one available treatment option for erectile dysfunction, which must be continued throughout the study; having normal libido; and having a partner able to engage in sexual intercourse for treatment assessment.	Presence of urogenital neoplasms; history of radical prostatectomy; testosterone levels below 350 ng/ml; diagnosed depression with the use of antidepressants; anatomical abnormalities of the genital tract; insufficient sexual activity to allow assessment of the response to the proposed treatment; and any clinical condition that contraindicates the treatment planned in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-984vvk7	Study on the filler content in flowable composite resin and its effect on the clinical performance of restorations in dental cavities close to the gingiva	Recruiting	Intervention	2025-10-23	<NULL>	<NULL>	8450	Does the filler content in flowable composite resin influence clinical performance when restoring non-carious Cervical Lesions? randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-04	Sociedade Civil Educacional Tuiuti Limitada	Sociedade Civil Educacional Tuiuti Limitada	https://ensaiosclinicos.gov.br/rg/RBR-984vvk7	<NULL>	Adults aged 18 years or older of both sexes; good general and oral health according to the Simplified Oral Hygiene Index; presence of at least 20 functional teeth; presence of at least two non-carious cervical lesions located in enamel and dentin with a minimum depth of 1 millimeter and less than 50 percent of the cavosurface margin in enamel; vital and asymptomatic teeth without contact with removable partial denture clasps; teeth with clinically acceptable restorations on other surfaces; availability to attend follow-up appointments and to sign the informed consent form	Active periodontal disease with probing depth greater than 3 millimeters bleeding on probing or mobility equal to or greater than grade II; presence of parafunctional habits such as bruxism or clenching of teeth; current use of orthodontic appliances or complete dentures; smoking; pregnancy or lactation; teeth serving as abutments for fixed or removable dentures; inability to attend follow-up appointments or refusal to sign the informed consent form; known allergy or hypersensitivity to any dental material used in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-3p8pxy5	Monitoring vivax malaria treatment with educational information support	Recruitment completed	Intervention	2025-10-23	<NULL>	<NULL>	8451	Assessment of adherence to vivax malaria treatment through educational/informative materials (AdheVivax)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Fundação de Medicina Tropical do Amazonas - FMT/IMT/AM	Fundação de Medicina Tropical do Amazonas - FMT/IMT/AM	https://ensaiosclinicos.gov.br/rg/RBR-3p8pxy5	<NULL>	Aged 16 years or older at the time of enrollment; Laboratory-confirmed diagnosis of uncomplicated Plasmodium vivax malaria; Prescribed a chloroquine and primaquine daily treatment regimen according to national guidelines; Access to a personal mobile phone capable of receiving SMS or WhatsApp messages; Provided written informed consent before study participation	Diagnosis of severe malaria or infection with non-P. vivax species; Inability to provide informed consent due to severe cognitive impairment; No access to a mobile phone capable of receiving SMS or WhatsApp messages; Known contraindications or allergies to chloroquine or primaquine; Residence outside the study&apos;s catchment area where follow-up is not feasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-696vpmn	Comparison between Dry needling and Percutaneous microelectrolysis techniques for Low back pain	Recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8436	Comparison between Dry needling and Percutaneous microelectrolysis techniques on muscle Trigger points in the lumbar spine	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-07	Universidade São Francisco	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-696vpmn	<NULL>	Participants aged 18 to 60 years; Both genders; Clinical diagnosis of nonspecific chronic low back pain; Period of more than 6 months with pain with tender points in the lower back on palpation	Neurological symptoms; Loss of strength; Loss of sensitivity; Loss of osteotendinous reflexes; Pain following an anatomical nerve path; Pain below the knee; Pacemaker; Neoplasms; Allergic to metals; Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-8jqwv9z	Whole-body Electrical Stimulation in patients with Heart Failure	Recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8437	Acute and chronic effects of Whole-body Electrostimulation on muscle oxygenation and blood flow in patients with Heart Failure: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Centro de Ciências Biológicas e da Saúde	Hospital Universitário da Universidade Federal de São Carlos - HUUFSCar	https://ensaiosclinicos.gov.br/rg/RBR-8jqwv9z	<NULL>	Individuals of both sexes, age ≥ 60 years, with Heart Failure diagnosed by echocardiography (left ventricular ejection fraction &lt;50%) undergoing treatment with optimized medication who are not experiencing exacerbations of the disease and are not participating in a cardiac rehabilitation program	Presence of decompensated Heart Failure; uncontrolled systemic arterial hypertension and pulmonary hypertension; use of pacemaker; use of home oxygen therapy; concomitant respiratory diseases; neurological; sensory or orthopedic alterations that prevent the proposed assessments from being carried out	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-8r2twnx	Effects of breathing training on lung health, fitness, and heart rate after coronary artery bypass graft surgery	Recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8438	Effects of inspiratory muscle training on lung function, functionality, and heart rate variability after myocardial revascularization: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-22	Universidade Federal do Piauí Campus Universitário Ministro Petrônio Portella	Universidade Federal do Piauí Campus Universitário Ministro Petrônio Portella	https://ensaiosclinicos.gov.br/rg/RBR-8r2twnx	<NULL>	Volunteers undergoing Myocardial Revascularization surgery; able to complete the Cardiac Rehabilitation program phase II; both genders; without obesity; preserved cognition	Volunteers with diseases that limit functionality or that interfere with the performance of respiratory muscle training; do not sign the Informed Consent Form; fail to participate in one of the research stages; attend less than eight weeks or 24 sessions in the cardiac rehabilitation program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-7fg2mgr	Exergame feedback on dynamometric performance in the 5-STS test	Recruitment completed	Intervention	2025-10-22	<NULL>	<NULL>	8439	Influence of enriched feedback through an exergame on dynamometric muscle performance during the 5-Sit-to-Stand test: A pilot study in healthy young adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-11	Universidad Andrés Bello	Universidad Andrés Bello	https://ensaiosclinicos.gov.br/rg/RBR-7fg2mgr	<NULL>	Regular students from Universidad Andrés Bello, Concepción campus; aged between 18 and 30 years; without musculoskeletal, cardiovascular, or neurological conditions that could hinder the proper and safe performance of the tests	Previous experience with the exergame Ring Fit Adventure; regular participation in physical or sports training programs at a competitive level during the last 3 months; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-4bmwsdz	Study on the use of Ibogaine for the treatment of Cocaine and Crack Addiction	Not yet recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8440	Phase II/III randomized and multicenter clinical trial to analyze the efficacy and safety of Ibogaine (Voacanga africana) in the treatment of Cocaine and Crack Dependence	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2026-01-01	Instituto Veracruz de Pesquisa e Tratamento da Dependência Química Ltda.	Instituto Veracruz de Pesquisa e Tratamento da Dependência Química Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-4bmwsdz	<NULL>	Volunteers able to understand the study procedures and voluntarily consent by signing the Informed Consent Form. Men and women aged between eighteen and fifty-five years. Diagnosis of mental and behavioral disorders due to use of cocaine, dependence syndrome or mental and behavioral disorders due to multiple drug use or use of other psychoactive substances, dependence syndrome, classified as severe. Clinical, physical and psychological evaluation within normal limits or with alterations not clinically significant at the investigators discretion. History of at least one unsuccessful attempt to reduce or cease substance use, such as hospitalization, therapeutic community treatment, self help groups or psychological follow up. Agreement to maintain abstinence from cocaine and or crack for thirty days prior to administration of the investigational product. Agreement to maintain abstinence and washout from other substances and medications prior to administration of the investigational product. Availability to participate in all stages of the protocol, including twenty four hours of hospitalization and twenty four weeks of outpatient follow up	Volunteers with a history of severe cardiovascular diseases including angina, acute myocardial infarction, coronary artery disease, heart failure, arrhythmias, endocarditis, syncope of unknown origin or significant electrocardiographic alterations. Uncontrolled systemic arterial hypertension. Uncontrolled diabetes mellitus. Clinically relevant hepatic, renal, gastrointestinal, pulmonary, hematological or metabolic diseases. Previous diagnosis of severe neurological or psychiatric disorders such as schizophrenia, bipolar disorder, other psychoses, epilepsy, Alzheimers disease, Parkinsons disease or head trauma with loss of consciousness. Previous or current history of suicidal ideation. Previous treatment with ibogaine or noribogaine. Known hypersensitivity to ibogaine, its derivatives or excipients of the investigational product formulation. Clinically significant alterations in safety laboratory tests or in the twelve lead electrocardiogram that may endanger the participants health at the investigator’s discretion. Use of antidepressants within thirty days before administration of the investigational product. Use of nicotine within twelve hours before or forty eight hours after administration of the investigational product. Use of alcohol within fifteen days prior to administration. Confirmed pregnancy or lactation. Positive serology for HIV, hepatitis B or hepatitis C. Positive drug test on the day of ibogaine administration except for substances for which there is no restriction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-4jpxy84	Surgical treatment for thumb arthritis: trapeziectomy vs trapeziometacarpal arthrodesis	Recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8441	Randomized clinical trial - surgical treatment of rhizarthrosis: trapeziectomy vs. trapeziometacarpal arthrodesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4jpxy84	<NULL>	Volunteers diagnosed with rhizarthrosis in stages II and III of the Eaton and Littler classification; age over 40 years	Previous surgical treatment for rhizarthrosis; rhizarthrosis in stage IV of the Eaton and Littler classification; tendon injury or fractures of the metacarpals or phalanges that generate functional limitation; previous surgical treatment for the carpal bones; contraindication to the anesthetic procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-7jkmhf5	Doxi-Rio: study on the use of Doxycycline to prevent sexually transmitted infections in Rio de Janeiro	Not yet recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8442	Doxi-Rio: pilot implementation of post-exposure prophylaxis for sexually transmitted infections with Doxycycline in Rio de Janeiro, Brazil	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Instituto Nacional de Infectologia Evandro Chagas	Instituto Nacional de Infectologia Evandro Chagas	https://ensaiosclinicos.gov.br/rg/RBR-7jkmhf5	<NULL>	Men (cis or trans) who have sex with men, transvestites or trans women; diagnosed with HIV infection or current use of PrEP for at least 6 months; age 18 years or older; laboratory diagnosis or self-reported diagnosis of at least one bacterial sexually transmitted infection (Chlamydia, Gonorrhea or Syphilis) in the last 12 months; consent to participate in the study after receiving adequate information about the study	Allergy to antibiotics of the Tetracycline class; current medications that may impact the metabolism of Doxycycline or that are contraindicated with Doxycycline (Systemic Retinoids, Barbiturates, Carbamazepine and Phenytoin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-86zkxm3	Foot Reflexology to Promote Women&apos;s Health During Menopause: An Holistic Approach	Data analysis completed	Intervention	2025-10-22	<NULL>	<NULL>	8443	Application of Foot Reflexology in promoting women&apos;s during the Climacteric: A holistic approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Cesumar	Universidade Cesumar	https://ensaiosclinicos.gov.br/rg/RBR-86zkxm3	<NULL>	Participants who reported being in the climacteric period regardless of having reached menopause; presenting complaints related to this phase such as headaches, night sweats, hot flashes, insomnia, fatigue, anxiety, irritability, vaginal dryness, and mental exhaustion; willing to answer all questions in the assessment instruments; signed the Free and Informed Consent Form; agreed with the study selection method based on simple random allocation; open to receiving the intervention protocol if allocated to the intervention group	Mulheres que apresentaram sintomas severos de saúde mental autoreferidos como transtornos de personalidade ou depressão profunda; incapacidades físicas ou cognitivas que impedissem a locomoção até o local de atendimento ou a resposta aos questionários; condições médicas pré-existentes nas quais a técnica aplicada fosse contraindicada como trombose venosa, epilepsia, gestação, infecções, lesões ou feridas abertas nos pés ou histórico de tuberculose; participantes que faltassem em duas sessões consecutivas também foram excluídas do estudo	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-6nt4hkm	Effect of Postural Insoles on Women&apos;s Muscle Health	Recruiting	Intervention	2025-10-22	<NULL>	<NULL>	8444	Effect of postural insoles on fibroedemagelloid, muscle strength and trophism in women: Double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-10	Universidade Federal de Alfenas - UNIFAL-MG	Universidade Federal de Alfenas - UNIFAL-MG	https://ensaiosclinicos.gov.br/rg/RBR-6nt4hkm	<NULL>	Participants must be female; aged between 18 and 45 years at the date of assessment; have signed the informed consent form; report fibroedemageloid, confirmed using a validated scale; women who are menstruating on the day of assessment will not be included and will be rescheduled for a new date	Pregnant women; women in menopause; with history of orthopedic injury and/or surgery in the lower limbs within the last six months; dermatological lesions such as ulcers or surgical scars; undergoing aesthetic treatment in the evaluated region; history of neurological, rheumatological, or endocrine diseases diagnosed within the last year; volunteers who have not signed the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-62kz97v	Effect of specific Exercise with orthopedic Brace combined customized Insole in adolescents with Idiopathic Scoliosis	Not yet recruiting	Intervention	2025-10-21	<NULL>	<NULL>	8430	Therapeutic effect of specific Exercise and use of orthopedic Brace combined with 3D customized Insole in adolescents with Idiopathic Scoliosis: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-31	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	https://ensaiosclinicos.gov.br/rg/RBR-62kz97v	<NULL>	Adolescents aged 11 to 18 years; diagnosis of adolescent idiopathic scoliosis; both genders	Symptomatic musculoskeletal diseases in the lower limbs; symptomatic diseases of the central and peripheral nervous system; diabetes mellitus; corrective surgery for spinal curvature; rigid foot deformities; injections in the feet and ankles in the last three months; previous or planned spinal surgery in the next twelve months; and mental disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-76pk39r	Effects of a motor training program integrated with cognitive, behavioral, and narrative strategies in children with autism	Recruitment completed	Intervention	2025-10-21	<NULL>	<NULL>	8432	Global integration method (MIG): a mixed-methods RCT on the effects of a motor training program integrated with cognitive, behavioral, and narrative strategies in children with autism	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Instituto de neurodesenvolvimento, cognição e educação inclusiva	Faculdade de Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-76pk39r	<NULL>	Participants diagnosed with Autism Spectrum Disorder (ASD); aged between 6 and 12 years at the start of the intervention and classified as levels 1 or 2 of support	Participants with cognitive, behavioral or medical changes that prevent them from following instructions and safely participating in activities proposed in the intervention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-83g3wys	Sodium Bicarbonate and Caffeine effects in performance in judo and jiu-jitsu fighters	Recruiting	Intervention	2025-10-21	<NULL>	<NULL>	8433	Can Sodium Bicarbonate supplementation combined with Caffeine be effective in improving performance in judo and Brazilian jiu-jitsu fighters?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Unicesumar	Laboratório Interdisciplinar de Intervenção em Promoção da Saúde (LIIPS)	https://ensaiosclinicos.gov.br/rg/RBR-83g3wys	<NULL>	Healthy volunteers; Male; Age between 18 and 45 years; Purple belt to black belt; training frequency equal to or greater than three times a week in specific training for the sport; training for at least three uninterrupted months	Athletes who have suffered injuries; belonging to the ultra-heavyweight category; individuals who are losing body mass; using drugs like anabolic steroids or illicit drugs; using medications like antibiotics or anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:15
RBR-4d9p9j5	Pilates Program for Knee Arthritis: Using an Educational Guide	Not yet recruiting	Intervention	2025-10-21	<NULL>	<NULL>	8434	Adherence to an Educational Booklet for Knee Osteoarthritis after a Pilates program	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4d9p9j5	<NULL>	Participants must have a clinical diagnosis of osteoarthritis according to the criteria of the American College of Rheumatology, which include knee pain and the presence of at least one of the following characteristics, age equal or above 50 years, knee crepitus during movement, increased sensitivity to compression, reduced local warmth, bony enlargement, morning stiffness lasting less than 30 minutes or radiological evidence of knee osteoarthritis of grade 2 or higher according to the Kellgren and Lawrence criteria which are as follows, grade 0 (no changes), grade 1 (doubtful joint space narrowing and possible osteophytes), grade 2 (possible joint space narrowing with definite osteophytes), grade 3 (definite joint space narrowing, definite osteophytes, and subchondral sclerosis with possible bony deformity), and grade 4 (marked joint space narrowing, definite osteophytes, definite bony deformity, and severe subchondral sclerosis); present a score equal or above 3 on the numerical pain rating scale	Asymptomatic knee osteoarthritis; surgeries performed on the lower limbs; confirmed diagnosis of neurological, inflammatory, infectious, rheumatologic, or traumatic disorders; severe visual impairment; presence of lower limb prosthesis; inability to understand the Portuguese language; body mass index (BMI) greater than 40; physiotherapy treatment within the past three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-2p25mw5	Effect of laser application on oral mucosa inflammation in patients undergoing Chemotherapy	Terminated	Intervention	2025-10-21	<NULL>	<NULL>	8435	The prognostic and therapeutic effect of low-level Lasertherapy on Oral Mucositis in patients undergoing Chemotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-05	Hospital Nossa Senhora da Conceição	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-2p25mw5	<NULL>	Diagnosed with head and neck cancer (oral cavity, oropharynx and nasopharynx); both genders; chemotherapy for treatment of cancer; no painful symptoms; no diagnosis of oral mucositis	Patients who had already undergone chemotherapy treatment; any grade higher tan 0 in the Visual Analogic Scale (VAS) of painful symptoms; grade I, II, III or IV oral mucositis; using medications to control oral mucositis; patients who did not agree to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-6fcwx9s	Comparison between the direct cut technique above the duodenal papilla and the traditional attempt to access the bile duct	Not yet recruiting	Intervention	2025-10-20	<NULL>	<NULL>	8425	Needle-knife fistulotomy versus conventional cannulation attempt: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-02-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6fcwx9s	<NULL>	Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) for the first time; favorable papillary morphology; infundibular bulging of at least 8 mm, with a minimum distance of 3 mm from the papillary orifice and a minimum length of 5 mm for endoscopic incision; age over 18 years; agreement with the Informed Consent Form	Refusal to sign the Informed Consent Form (ICF); previous endoscopic retrograde cholangiopancreatography (ERCP); coagulopathy; surgical history that alters endoscopic access to the biliary tract (e.g., gastrectomy with Billroth II or Roux-en-Y reconstruction); pancreatic sphincterotomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:07
RBR-7bcs3m4	Reducing ageism against older adults: evaluation of the effectiveness of an educational intervention in Primary Health Care	Not yet recruiting	Intervention	2025-10-20	<NULL>	<NULL>	8426	Ageism among Primary Health Care professionals: associated factors and effectiveness of an educational intervention in reducing ageist attitudes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-15	Faculdade de Enfermagem - FENF / Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-7bcs3m4	<NULL>	Health professionals with mid-level or higher education; both genders; working in Primary Health Care Units for at least three months; weekly workload equal to or greater than 30 hours	Professionals absent from work for any reason including vacation and leave; participants not reached by phone after three attempts at different days and times; non-completion of the intervention on the Moodle platform	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:09
RBR-3hvvcqk	Study to evaluate whether Melatonin can help children with Autism who have trouble sleeping	Recruitment completed	Intervention	2025-10-20	<NULL>	<NULL>	8427	Evaluation of the effectiveness of Melatonin Supplementation in children on the Autism Spectrum with Sleep Disorder	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade de Brasília - PPG- Ciências Médicas - Faculdade de Medicina	Universidade de Brasília - PPG- Ciências Médicas - Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-3hvvcqk	<NULL>	Clinical diagnosis of Autism Spectrum Disorder (ASD) according to DSM-5; children aged 4 to 12 years; both sexes; not using hypnotic medications; caregivers report difficulties related to sleep quality (daytime sleepiness), time to fall asleep (delay of at least 30 minutes to fall asleep), or staying asleep (frequent night awakenings with difficulty returning to sleep); verbal IQ above 50, using the Wechsler Intelligence Scale for Children	Patients using hypnotic medications; with other complex medical conditions such as epilepsy, schizophrenia, or multiple sclerosis; diagnosed with oppositional defiant disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-3mnn2t4	Effect of reinforcement fiber on post-operative sensitivity of Bulk-Fill resin restorations in posterior teeth: a double-blind randomized clinical trial	Recruitment completed	Intervention	2025-10-20	<NULL>	<NULL>	8428	Effect of fiber reinforcement on postoperative sensitivity in Class I and II posterior teeth restorations using the Bulk-Fill technique: a randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Odontologia da Universidade Federal do Amazonas.	Faculdade de Odontologia da Universidade Federal do Amazonas.	https://ensaiosclinicos.gov.br/rg/RBR-3mnn2t4	<NULL>	Volunteers over the age of 18, of both sexes, without systemic diseases, with good oral hygiene conditions, and without periodontal disease. Regarding dental aspects, volunteers must present at least one posterior vital tooth, with no history of previous dentin hypersensitivity, presenting either a carious lesion requiring restoration or a deficient posterior restoration that needs replacement (due to caries, fractures, or reasons reported by the patient). The lesions must be classified as Class I or II (involving the occlusal surface), with a minimum depth of 2 mm, which will be assessed through digital bitewing radiographs and a millimeter ruler. In addition, the teeth requiring restorative treatment must have an antagonist tooth in occlusion	Participants who require endodontic treatment (to be assessed by radiographic examination and cold pulp vitality test), as well as those who have already undergone endodontic therapy in the tooth in question, and those presenting with periodontal problems. Pregnant or breastfeeding participants, individuals with a history of allergy to any of the materials to be used in the research, participants with bruxism or significant oral pathologies, participants with non-carious cervical lesions, and those currently using or who have used anti-inflammatory drugs, analgesics, or psychotropic medications (as these may mask the results of postoperative sensitivity) within the 15 days prior to the restorative procedure will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-6j98hjx	Evaluation of the effect of medications in the treatment of dental infections in healthy patients and patients who have undergone radiotherapy to the head and neck region	Recruiting	Intervention	2025-10-20	<NULL>	<NULL>	8429	Clinical evaluation of intracanal medications on lipid mediators, inflammatory cytokines and effect on bacteria and products in endodontic infections of healthy patients or treated with head and neck radiotherapy	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2022-03-06	Instituto de Ciência e Tecnologia de São José dos Campos da Universidade Estadual Paulista	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-6j98hjx	<NULL>	Permanent teeth; primary endodontic infection; single-rooted teeth with a single canal; periapical lesion; both genders; patients over 18 years of age	Periodontal pocket greater than 4 mm; teeth that cannot be isolated; root fracture or pulp chamber exposure; use of antibiotics or antifungal agents within 3 months prior to the start of treatment; presence of systemic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-9tn4ncp	How Strength Training can help reduce Depression Symptoms and improve health in adults diagnosed with Depression	Recruiting	Intervention	2025-10-17	<NULL>	<NULL>	8422	Non-pharmacological interventions to improve the Psychophysiological Health of adults with and without Major Depressive Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-17	Univerdade Estadual Paulista Júlio de Mesquita Filho	Univerdade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-9tn4ncp	<NULL>	Men or women aged 18 to 59; Diagnosis of major depressive disorder (single or recurrent episodes) by a psychiatrist; No psychiatric comorbidities such as schizophrenia, bipolar disorder, or substance abuse disorder; For women, not being pregnant or lactating; No participation in regular resistance training in the past six months; No cardiovascular or musculoskeletal contraindications that may limit participation in the exercise program	Missing six or more exercise sessions during the intervention; Missing three consecutive sessions; Failing to complete the scheduled assessments during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-56gdnqk	Effects of Laser Therapy on the lips of mouth-breathing children	Not yet recruiting	Intervention	2025-10-17	<NULL>	<NULL>	8423	Effects of Orofacial Myofunctional Therapy combined with Photobiomodulation in mouth-breathing children: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-56gdnqk	<NULL>	Mouth-breathing children of both sexes, aged between 5 and 12 years; who have signed the Informed Assent Form (IAF) and whose respective guardian has signed the Informed Consent Form (ICF); who have not used muscle relaxant and/or anti-inflammatory medication within the 48 hours prior to data collection; participants who do not present contraindications to phototherapy	Failure to complete all proposed tasks; low quality of the electromyographic signal; absence of dento-skeletal conditions necessary to achieve lip sealing; obstruction that prevents nasal breathing; lip sealing performed with effort	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-5czhc4k	Promoting cognitive health in physically active older adults: the role of Creatine and Strength Training over 12 weeks	Recruitment completed	Intervention	2025-10-17	<NULL>	<NULL>	8424	MedEpiGen Project: Preventive Medicine for Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-20	Programa de Pós-Graduação em Genética da Universidade Federal do Paraná	Universidade Estadual do Centro Oeste	https://ensaiosclinicos.gov.br/rg/RBR-5czhc4k	<NULL>	Be regular exercisers for at least 12 months. Comply with the physical activity recommendations of the World Health Organization (WHO). Have medical clearance to take part in the study. Controlled blood pressure, no metabolic or endocrine disorders.  Zero score on the cognitive assessment (CDR). Have attended regular school for at least 4 years. Aged 60 or over. Both sexes	Missing a training session without making up for it. Any falls that compromise exercise. Presenting metabolic, endocrine or renal disorders after starting the program, detected during a routine consultation with the general practitioner. Need for intervention with any type of medication not listed above. Cognitive assessment (Clinical Dementia Rating - CDR) with a result higher than zero	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-73hswmb	Laterality and mirror therapy for surgically treated distal radius Fracture	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8416	Effectiveness of a laterality and mirror therapy protocol versus graded motor imagery on pain, function, and quality of life in women with surgically treated distal radius Fracture: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Hospital Herminda Martin	Universidad San Sebastián	https://ensaiosclinicos.gov.br/rg/RBR-73hswmb	<NULL>	Women; over 18 years old; diagnosed with Unilateral Distal Radius Fracture and treated surgically	Polytraumatized patients; patients with secondary distal radius fractures (tumors, pathological bone, etc.); complicated distal radius fractures (associated with other musculoskeletal, vascular, or neurological injuries); patients with decompensated rheumatic, neurocognitive, or psychiatric diseases; patients with visual impairment preventing completion of study protocols; cognitive impairment assessed with the Mini-Mental State Examination (MMSE); and patients with complex regional pain syndrome (CRPS) at baseline	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-7zbz3p3	Auriculotherapy in the birth process	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8417	Effects of Auriculotherapy on the birth process: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-04-01	Universidade Estadual de Londrina	Santa Casa de Misericórdia de Cambé	https://ensaiosclinicos.gov.br/rg/RBR-7zbz3p3	<NULL>	Chronological age over 18 years; from 37 weeks; regardless of parity; who are admitted for induction of labor	Pregnant women who are induced using the Krause method	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-7jv6k2n	Effects of Leucine Supplementation in Patients with Stomach and Bowel Cancer.	Recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8418	Leucine supplementation in patients with gastrointestinal cancer: effects on body composition and inflammatory parameters	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-11-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7jv6k2n	<NULL>	Patients with gastrointestinal cancer (stomach, esophagus, colon, or rectum), with and without weight loss. Ages between 40 and 90 years. Both sexes	Neoplasms of organs adjacent to the gastrointestinal tract, such as the pancreas, liver, or small intestine. Autoimmune diseases, obesity, inflammatory bowel disease, Crohn&apos;s disease, acquired immunodeficiency syndrome, chronic obstructive pulmonary disease (COPD), and other inflammatory diseases were excluded. The presence of other types of cancer, kidney or liver failure, psychotic disorders, or dementia, as well as any cognitive condition that compromises the ability to respond to the questionnaires, was also considered an exclusion criterion. Individuals who used anti-inflammatory drugs or corticosteroids during the supplementation period were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-3t3z37t	Comparison of the effects of two suspension training protocols on the pain and musculoskeletal function of individuals with chronic low back pain	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8419	Comparison of the effects of two suspension training protocols on pain and skeletal muscle function of individuals with chronic low back pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-10	Universidade Federal do Paraná	Centro de Estudos em Prescrição Clínica do Exercício (CEPREX)	https://ensaiosclinicos.gov.br/rg/RBR-3t3z37t	<NULL>	Volunteers with chronic, nonspecific, persistent, or periodic low back pain; military personnel; age range between 18 and 59 years; pain intensity greater than 3 on the numerical pain scale; moderately active according to the Human Activity Profile Questionnaire.	Body mass index greater than or equal to 30 kg/m2; no physiotherapy treatment concurrent with the study period; no surgery in the lumbar region; no clinical diagnosis of low back pain; no low back pain radiating to the glutes and lower limbs; use of medication for low back pain relief 48 hours before performing the exercises; previous diagnosis of heart disease; neurological disease; uncontrolled hypertension (less than 1 year after starting medication); acute lung disease; orthopedic injuries; failure to sign the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-2w8s4r9	Randomized clinical trial comparing primary anterior cruciate ligament reconstruction with hamstring grafts with and without the bioinductive implant Biobrace®	Not yet recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8420	Randomized double-blind clinical trial comparing the functional outcomes of patients undergoing primary anterior cruciate ligament reconstruction with hamstring grafts with and without the use of intra-articular reinforcement with the bioinductive implant Biobrace®	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2w8s4r9	<NULL>	Patients with unilateral anterior cruciate ligament injury with surgical indication, with or without associated meniscal lesions; Patients with skeletal maturity; Both genders; Aged between 16 and 50 years	Presence of other associated ligament injuries requiring reconstruction; Patients with mechanical axis deviation of the lower limb requiring corrective osteotomy; Presence of chondral lesions requiring repair; Presence of associated fractures or other pathological conditions of the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-5xs4bp9	Effects of Progressive Muscle Strengthening and Whole Body Vibration in Older Adults with Type II Diabetes	Recruiting	Intervention	2025-10-16	<NULL>	<NULL>	8421	Effects of whole-body vibration combined with progressive resistance exercise on muscle strength, functional capacity, body composition, and biological parameters in older adults with type II diabetes: a single-blind randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-30	Universidade Federal de Minas Gerais	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5xs4bp9	<NULL>	Be 60 years of age or older; have a medical diagnosis of Type II Diabetes; be considered active based on the results of the International Physical Activity Questionnaire; be independent in walking; have signed the free and informed consent form	Type 1 Diabetes; renal and hepatic insufficiency; retinopathy; plantar injuries; previous history of cerebral aneurysm; neurological diseases (Parkinson&apos;s, stroke, traumatic brain injury, spinal cord injuries and multiple sclerosis); cognitive alterations detected in the Mini Mental State Examination (MMSE) (score ≤ 13 for illiterates, ≤ 18 for low and medium and ≤ 26 for high education); current oncological treatment; Present signs of thrombosis; pacemaker wearer;  presence of metal implants;  have orthopedic limitations that prevent training on the platform or tests; recent surgeries or fractures (≤ 4 months); having received whole body vibration treatment in the last six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-67bq38w	Effect of testosterone replacement in hypogonadal men with overweight and obesity: a clinical trial	Not yet recruiting	Intervention	2025-10-15	<NULL>	<NULL>	8415	Effect of testosterone replacement associated with diet and physical activity in hypogonadal men with overweight and obesity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Hospital e Maternidade São Domingos	Hospital e Maternidade São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-67bq38w	<NULL>	Obese or overweight men (Body Mass Index above 25 and less than 35; between 30 and 60 years of age; with low testosterone levels (less than 350 nanograms per deciliter); with symptoms of hypogonadism	Individuals interested in fertility in the 6 months following therapy; presence of Diabetes Mellitus; presence of hypertension; presence of Nephropathy; presence of heart disease; presence of Hepatopathy; presence of Depression; presence of anxiety disorders; presence of other hormonal diseases; presence of Hypogonadism of primary cause (testicular failure); diagnosis of active prostate or breast cancer; previous diagnosis of breast cancer; severe urinary symptoms through the score; International Prostate Symptom Score greater than 19; severe cardiopulmonary disease such as unstable angina and recent myocardial infarction; personal or family history of Thromboembolism; hematocrit above 48 percent; patients with implanted medical devices (pacemakers) or essential support devices such as monitors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-49bf8qs	How feet position and orientation during the Leg Press exercise influence the growth and strength of leg muscles	Recruitment completed	Intervention	2025-10-14	<NULL>	<NULL>	8406	Effect of feet position and verbal instruction in the Leg Press 45° on Hypertrophy and Strength of the knee and hip extension muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-49bf8qs	<NULL>	No resistance training in the last 6 months; have between 18 and 40 years old; both sexes	Have a history of musculoskeletal injuries in the lower limbs in the last 12 months; present any health problem that interferes with the execution of the proposed exercises and assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-4q882tg	Development of a mobile application on dental prenatal care and early childhood oral health: using technology as an educational tool to combat misinformation	Recruiting	Intervention	2025-10-14	<NULL>	<NULL>	8407	Development and validation of the effectiveness of a mobile application on dental prenatal care and early childhood oral health: using technology as an educational tool to combat misinformation	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2025-07-28	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo (FORP-USP)	https://ensaiosclinicos.gov.br/rg/RBR-4q882tg	<NULL>	Pregnant women at any gestational age; mothers aged 18 years or older; children up to 6 years of age of both sexes; good general health; smartphone with internet access	Mothers without a smartphone with internet access; mothers under 18 years of age; children older than 6 years; mothers with complete upper and lower dentures; mothers with fixed orthodontic appliances; mothers with learning difficulties	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-1066hnnx	Cavity-free city: how to keep children&apos;s teeth healthy	Recruitment completed	Intervention	2025-10-14	<NULL>	<NULL>	8408	Zero-Caries municipality: an oral health proposal for the child and adolescent population	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-1066hnnx	<NULL>	Individuals aged 6 to 16 years; presence of at least one permanent first molar with occlusal caries lesion class I classified as International Caries Detection and Assessment System 4, 5 or 6	Individuals with systemic diseases or conditions that contraindicate the proposed procedures; caries lesions classified as International Caries Detection and Assessment System 1, 2 or 3; presence of severe hypoplasia, extensive fractures or pulp necrosis in permanent molars	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-526tmt3	Effects of Contensive Taping in the immediate postpartum cesarean: a clinical study	Recruiting	Intervention	2025-10-14	<NULL>	<NULL>	8410	Evaluation of Contensive Taping in post-cesarean recovery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade do Estado de Minas Gerais Unidade Divinópolis	Universidade do Estado de Minas Gerais Unidade Divinópolis	https://ensaiosclinicos.gov.br/rg/RBR-526tmt3	<NULL>	Postpartum women over 18 years of age; who underwent cesarean delivery from 1 to 7 days postpartum; and who did not experience any type of complication during delivery	Women with twin pregnancy; gestational diabetes and preeclampsia; those with complications related to the surgical wound, such as dehiscence and infection; those with hemorrhage, deep vein thrombosis, any other active infections, fever, dehydration, dizziness, and fainting	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-4pf8kms	Should we wait until sufficient good teeth brushing before periodontal treatment? A randomized clinical trial	Not yet recruiting	Intervention	2025-10-14	<NULL>	<NULL>	8411	Influence of achieving sufficient mechanical control of the supragingival biofilm before subgingival instrumentation in patients with Periodontitis: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4pf8kms	<NULL>	Periodontitis Stages II-IV Grades B and C, generalized: for Stages II-IV (case definition): present at least 1 tooth with at least one interproximal site with a probing depth greater than or equal to 5 mm and attachment loss greater than or equal to 4 mm. For Grade B: have a report of attachment loss of less than 2 mm in the last 5 years or have a bone loss/age percentage (of the most affected tooth) . between 0.25 and 1. For Grade C: have a report of attachment loss greater than or equal to 2 mm in the last 5 years or have a bone loss/age percentage (of the most affected tooth) greater than 1. Present a minimum of 15 teeth (excluding third molars and teeth indicated for extraction). Minimum of 6 teeth with at least 1 non-contiguous interproximal site with a probing depth greater than or equal to 5 mm and a clinical attachment level greater than or equal to 4 mm. Both sexes. Age greater than or equal to 30 years.	Smokers of at least 10 cigarettes/day for at least 5 years; former smokers for at least 5 years; pregnant or lactating; history of periodontal treatment in the last 6 months; continuous use of oral antiseptics; use of systemic antibiotics, corticosteroids, nonsteroidal anti-inflammatory drugs, immunosuppressants, estrogen, and estrogen receptor modulators; medications that may influence bone metabolism (alendronate, calcitonin, and others) in the last 6 months; systemic disease that may alter the host response to periodontal treatment (e.g., diabetes) or that requires prophylactic medication for dental treatment (e.g., mitral valve prolapse); use of orthodontic appliances; extensive prosthetic rehabilitation and blood dyscrasias; patients with motor limitations that have a significant impact on biofilm self-control (e.g., patients with stroke sequelae)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-102wbfbj	Helping people with depression using positive mental imagery to change how they interpret situations	Data analysis completed	Intervention	2025-10-14	<NULL>	<NULL>	8412	The role of interpretation bias in depressive disorder and efficacy of positive imagery based interpretation bias modification on depressive disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-15	University of Social Welfare and Rehabilitation Sciences	University of Social Welfare and Rehabilitation Sciences	https://ensaiosclinicos.gov.br/rg/RBR-102wbfbj	<NULL>	Individuals aged 18 years or older. Both genders. Diagnosis of Major Depressive Disorder based on DSM-5. Mild to moderate depression severity based on BDI-II score. Ability to use a smartphone and internet. Consent to participate in the study	History of bipolar disorder or psychotic disorders. Active suicidal ideation. Substance abuse in the past six months. Participation in another psychological intervention during the study period. Cognitive impairment or neurological disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-4k23pzf	Use of LED Mask for Prevention and Treatment of Oral Mucositis	Recruiting	Intervention	2025-10-14	<NULL>	<NULL>	8413	Development and Evaluation of a Protocol Using an LED Mask for extra-oral Photobiomodulation in the Prevention and Treatment of Oral Mucositis Induced by High-Dose Methotrexate	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Centro Universitário do Pará - CESUPA	Centro Universitário do Pará - CESUPA	https://ensaiosclinicos.gov.br/rg/RBR-4k23pzf	<NULL>	Patients aged between 6 and 18 years; of both genders; diagnosed with Acute Lymphoblastic Leukemia; undergoing Methotrexate treatment during the consolidation phase; following the Berlin-Frankfurt-Münster (BFM) 2012 protocol (5 g/m² over 24 hours by intravenous infusion), at the Oncology Department of the Octávio Lobo Children’s Oncology Hospital; patients or legal guardians who agree to and sign the Informed Consent Form	Presence of photosensitivity; loss of treatment follow-up; inability to complete the Visual Analogue Scale; refusal to undergo any Photobiomodulation session; and limitation in mouth opening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-5j5swn8	Study protocol on Aerobic Exercise and Multimodal Training for people with Parkinson’s disease	Not yet recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8392	Effect of Aerobic Exercise compared to a Multimodal Training on functional capacity and quality of life in individuals with Parkinson’s disease: randomized clinical trial protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-02	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-5j5swn8	<NULL>	Individuals diagnosed with Parkinson’s disease; minimum age of 30 years; both sexes; varying levels of education; currently at stages I, II, or III on the Hoehn &amp; Yahr scale	Individuals who present acute osteomyoarticular injuries or limiting cardiac alterations; Dementia; Uncontrolled severe psychiatric illness or current psychotic symptoms, which would be characterized as a contraindication for the practice of physical activity; Unjustified absence; clinical instabilityity practice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-10xbwbwg	Effect of Ozonized Water on Wound Healing in the Palate	Recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8393	Effect of Ozonated Water on the Healing of Surgical Palatal Wounds: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-22	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-10xbwbwg	<NULL>	Age between 18 and 60 years; in good general and oral health; present indication for free gingival graft; be undergoing treatment at the special periodontics clinic; have a surgical wound on the palate originating from the free gingival graft donor area; consent to participate in the research	Patients who smoke and/or drink alcohol; patients with systemic alterations that interfere with surgical wound healing (sickle cell anemia, diabetes mellitus); pregnant women; patients who present cognitive and/or neuromotor difficulties that compromise the stages of study development	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-63nvb2x	Speech therapy as an ally in the care of stubborn chronic cough	Data analysis completed	Intervention	2025-10-13	<NULL>	<NULL>	8394	Contributions of Speech-Language Pathology to the Treatment of Chronic Cough	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-12	Escola Paulista de Medicina da Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-63nvb2x	<NULL>	People over 18 years old; regardless of gender; diagnosed with Refractory chronic cough	Illiterate individuals; individuals without autonomy to provide assent to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-4hx89v9	Physiological indices during running on flat and uphill terrains: relationship with exercise intensity domains	Recruitment completed	Intervention	2025-10-13	<NULL>	<NULL>	8395	Physiological indices during level and uphill running: relationships with exercise intensity domains	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-08	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4hx89v9	<NULL>	Be at least 18 years old; have participated in at least one regional or national-level trail run competition; perform running training at least three times per week, with at least one session on uphill terrain, for a minimum of 12 months prior to the beginning of the study	Use of medications that could potentially interfere with the study results; smokers; participants with a history of injury in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-3p5bdgx	How different orthodontic appliances can help children with enlarged tonsils and adenoids	Recruitment completed	Intervention	2025-10-13	<NULL>	<NULL>	8396	Effects of Rapid Maxillary Expansion associated or not with Microsensor-Monitored Mandibular Advancement in children with maxillary Atresia and palatine adenotonsillar hypertrophy: a randomized, blinded, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-31	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-3p5bdgx	<NULL>	diagnosis of maxillary atresia, evidenced by negative values in the posterior region of the maxilla based on Korkhaus analysis, which allowed the identification of posterior maxillary constriction; hypertrophy of the palatine tonsils assessed by direct inspection, with only patients presenting grade III or IV hypertrophy being selected; adenoid hypertrophy, evaluated through lateral cephalometric radiographs of the middle and inferior turbinates, as well as the region caudal to the inferior turbinate, which were examined by an otorhinolaryngologist in a single-blind manner; presence of Class II malocclusion with mandibular retrusion; no history of adenoidectomy or tonsillectomy; no systemic disease or use of medication; Gender both sexes; Age between 7 and 11 years	Class I or Class III malocclusion; active dental caries or periodontal disease; craniofacial dimorphisms and/or anomalies; temporomandibular disorders; previous or current history of orthodontic, speech therapy, or otorhinolaryngologic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-5yhhywh	Comparison in open surgery of the use of sutures between the clavicle and the coracoid bone with the use of sutures between the clavicle and the coracoid associated with sutures between the clavicle and the acromion bone in acute acromioclavicular dislocations	Recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8397	Surgical treatment of acute acromioclavicular dislocation: Does acromioclavicular cerclage improve clinical and radiological outcomes of subcoracoid ligature? - Prospective randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital Universitário Professor Alberto Antunes	Santa Casa Misericórdia Maceió	https://ensaiosclinicos.gov.br/rg/RBR-5yhhywh	<NULL>	Patients of both sexes;over 18 years old; diagnosed with acute acromioclavicular dislocation within 21 days of injury; Rockwood type 3;4;5;6	Previous shoulder surgeries; multiple trauma patients; abuse of alcohol or illicit drugs; exposed injuries; carrier of neoplastic disease; associated fractures in the upper limb; adhesive capsulitis; glenohumeral osteoarthritis; psychiatric illness; pregnancy; comorbidities not clinically compensated; presence of active infection, loss of follow up of the first clinical evaluation carried out at 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-5j4wkxk	Effects of S-PRG Nanoparticles Dispersion on Gum Tissues	Not yet recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8398	Evaluation of the effects of S-PRG Nanoparticle dispersion on periodontal tissues: in vitro analysis of biological interactions and clinical trial in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-10	Instituto de Ciência e Tecnologia - São José dos Campos - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - São José dos Campos - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5j4wkxk	<NULL>	Individuals with gingivitis presenting a gingival bleeding index equal to or greater than 10%; probing depth equal to or less than 3 mm; aged 18 years or older; in good general health; and willing to participate in the study by signing the informed consent form	Individuals with periodontitis; smokers; pregnant or breastfeeding women; individuals who have used mouthwashes within the past 6 months; those under chronic use of medications that affect periodontal response, such as antibiotics, anti-inflammatory drugs, anticonvulsants, immunosuppressants, or sodium channel blockers within the past 6 months; individuals with systemic conditions such as diabetes, cardiovascular disease, cancer, obesity, rheumatoid arthritis, metabolic syndromes, respiratory diseases, or those requiring antibiotic prophylaxis; and individuals wearing orthodontic appliances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-5bftcwk	Tongue tie and motor development in children: a prospective cohort study	Not yet recruiting	Observational	2025-10-13	<NULL>	<NULL>	8399	Oral ties and motor development in children: a prospective cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-5bftcwk	<NULL>	Newborns over 37 weeks; weight greater than or equal to 2,500 grams; mothers aged at least 18 years	Babies with congenital anomalies or neonatal conditions that prevent breastfeeding; babies who require intensive care unit (NICU); babies whose mothers test positive for human immunodeficiency virus (HIV) and/or human T-cell lymphotropic virus (HTLV); babies from multiple pregnancies; mothers who live in other cities where transportation is difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-9vkxs6n	Supercoffee Supplement and Memory: Study with Medical Students	Recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8400	Evaluation of SuperCoffee supplementation on attentional performance and cognitive function of medical students: a randomized controlled clinical trial using EEG/NIRS	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-9vkxs6n	<NULL>	Healthy UNISUL medical students who do not have any diagnosed and/or treated disease	Students who already use supplements; have liver or kidney damage; use illicit drugs; any medication with a depressant effect on the central nervous system; students with immunosuppressive diseases; oncological diseases; infectious diseases or in a feverish state; epileptic diseases; with a diagnosis of depression; pregnant and/or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-7sfkbgw	Clinical and side effects evaluation of a Chlorhexidine Mouthwash associated with an antimicrobial substance found in citrus fruit and Hyaluronic Acid	Terminated	Intervention	2025-10-13	<NULL>	<NULL>	8401	Clinical and side effect evaluation of Chlorhexidine mouthwash in combination with Citrox and Hyaluronic Acid	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2019-04-26	Rafael de Oliveira Dias	Universidade de Mogi das Cruzes	https://ensaiosclinicos.gov.br/rg/RBR-7sfkbgw	<NULL>	subjects of both genders;aged 18 to be 60 years;good general health without systemic diseases;a minimum of 20 teeth;no periodontal sites with a probing depth greater than 3 mm;and no dental caries or restorations with infiltrations	sistemic diseases;periodontal diseases and dental cavities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-8r3vzw5	Study on how Dignity Therapy can help people with advanced cancer maintain their sense of dignity and well-being at the end of life	Not yet recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8402	Effects of Dignity Therapy on the sense of dignity and spiritual well-being of patients with advanced cancer at the end of life: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-15	Departamento de Enfermagem da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8r3vzw5	<NULL>	Age of eighteen years or older. All genders. Diagnosis of advanced cancer considered incurable, including solid tumors or hematologic malignancies. Life expectancy of six months or less, as determined by a score of three on the Eastern Cooperative Oncology Group performance scale or clinical judgment of the care team. Active participation in inpatient palliative care. Availability and willingness to participate in up to four sessions within a period of up to fourteen days. Functional ability to communicate in Portuguese. Cognitive functioning compatible with participation in the intervention, as assessed by the Mini-Mental State Examination	Severe cognitive impairment, such as dementia or delirium, that interferes with participation in the intervention, identified clinically or by the screening tool. Clinical diagnosis of severe mental disorder. Severe language disturbances that impair comprehension or communication. Evidence of a conspiracy of silence between the care team and the family	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-9rq7d8t	Effects of Pneumatic Compression, Vibration Therapy, and Photobiomodulation on Muscle Recovery after Muscle Damage	Recruitment completed	Intervention	2025-10-13	<NULL>	<NULL>	8403	Evaluation of the effects of Intermittent Sequential Pneumatic Compression associated with Local Vibration Therapy and Photobiomodulation on muscle recovery after a physical exercise-induced Muscle Damage protocol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-9rq7d8t	<NULL>	Healthy individuals; of both sexes; between the ages of 20 and 35; who regularly practice physical exercise	Have metabolic; musculoskeletal; cardiovascular; respiratory; or neurological disorders; have recent muscle strains/injuries; be using medications that affect muscles; recently use muscle recovery modalities; undergo ongoing physical therapy; and have allergies to materials	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-9nvk9zx	Pilot clinical trial comparing nimesulide, tramadol and dexamethasone for the prevention of pain and inflammation after wisdom tooth surgery	Terminated	Intervention	2025-10-13	<NULL>	<NULL>	8404	Multimodal preemptive analgesia in third molar surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-15	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-9nvk9zx	<NULL>	Adult patients (≥18 years old) treated at the Oral and Maxillofacial Surgery and Traumatology Clinic of UFVJM; bilateral indication for mandibular third molar extraction; asymptomatic; classified as class IIB according to Pell &amp; Gregory, and with similar surgical difficulty	Exclusion criteria included allergy to study medications; recent use of anti-inflammatory drugs; autoimmune diseases; HIV infection; tuberculosis; pregnancy; lactation; history of pericoronitis; cognitive impairments or refusal to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-5s76ksq	Non-invasive brain stimulation in neurological conditions	Not yet recruiting	Intervention	2025-10-13	<NULL>	<NULL>	8405	Non-invasive neuromodulation in neurological clinical conditions	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-5s76ksq	<NULL>	Participants aged 18 years or older; of both sexes; who provide written informed consent will be included; eligibility requires a functional diagnosis of communication disorders or stomatognathic dysfunctions of neurological etiology (dysphagia, dysphonia/dysarthrophonia, aphasia, or somatosensory tinnitus); a functional diagnosis of gait and balance disorders; chronic pain; and/or a sympathetic or parasympathetic index outside the normal range (–1 to 1) in heart rate variability, observed in at least two of the three measurements of the orthostatic test	Participants who do not use the Portuguese oral language; who have rheumatological diseases such as rheumatoid arthritis and ankylosing spondylitis; with cardiac arrhythmia or other cardiovascular conditions using beta-blockers; pregnant women or women in the puerperium or postpartum period; patients diagnosed with cancer and severe osteoporosis; who have absolute contraindications for non-invasive brain stimulation (pacemaker, epilepsy, cochlear implant)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-3rf99vw	Resistance training to improve the life of cancer survivors	Recruiting	Intervention	2025-10-11	<NULL>	<NULL>	8390	Effects of Resistance Training on Quality of Life, Mood Disorders, Spinal Curvature, Fatigue Indicators, and Muscle Performance in Breast Cancer Survivors	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Hospital das Clínicas Universidade Federal de Goiás	Hospital das Clínicas Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3rf99vw	<NULL>	Patients over 18 years old; not having started any cycle of chemotherapy; diagnosis of breast carcinoma confirmed by histopathological; being sedentary, having not exercised for at least 6 months	Patients with cognitive impairment or neurological diseases; patients with osteoarticular injuries that prevent physical activity; patients with previous malignancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-66mcspw	Acupuncture and Cognitive-Behavioral Psychotherapy for the treatment of Anxiety in women	Data analysis completed	Intervention	2025-10-11	<NULL>	<NULL>	8391	The use of Integrative and Complementary Practices in the Brazilian Unified Health System for the treatment of Anxiety in women of reproductive age	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Organização Mogiana de Educação e Cultura Sociedade Simples Ltda	Organização Mogiana de Educação e Cultura Sociedade Simples Ltda	https://ensaiosclinicos.gov.br/rg/RBR-66mcspw	<NULL>	Women; aged between 18 and 49 years; with a clinical diagnosis of anxiety according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); presenting moderate to severe symptoms measured by the Hamilton Anxiety Rating Scale (HAM-A)	Pregnant women; women using anxiolytic or antidepressant medication; those undergoing other forms of psychotherapy or acupuncture; women with severe psychiatric or neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-8z38nht	The role of Melatonin treatment in the Nutritional Health of patients who have had Pineal Gland Cancer	Recruitment completed	Intervention	2025-10-10	<NULL>	<NULL>	8386	Nutritional assessment of patients with Pineal Tumor before and after Melatonin replacement	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2021-11-22	Universidade Federal de São Paulo	Instituto de Oncologia Pediátrica - GRAACC/UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-8z38nht	<NULL>	Patients who have undergone surgical treatment for tumors in the pineal region; patients who have undergone chemotherapy for tumors in the pineal region; patients who have undergone radiotherapy for tumors in the pineal region	Current melatonin supplementation; diagnosis of eating disorders; use of appetite suppressants or other medications that chronically alter appetite	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-1024hsqk	Effects of combining Physical Literacy with a Physical Activity and Pain Education intervention for Older Adults with Chronic Pain in Muscles, Bones, and Joints	Recruiting	Intervention	2025-10-10	<NULL>	<NULL>	8387	Effect of integrating Physical Literacy into a Physical Activity and Pain Education intervention for Older Adults with Chronic Musculoskeletal Pain: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Estadual Paulista	Universidade Federal de Sâo Carlos	https://ensaiosclinicos.gov.br/rg/RBR-1024hsqk	<NULL>	"Age 60 years or older; Experience of persistent musculoskeletal pain for six months or more;
Independent walking; Receiving care from the Primary Health Care Unit in São Carlos, SP"	Suspected serious health conditions, as described in the literature, that may be associated with chronic musculoskeletal pain (CMP) and require medical referral, such as suspected fractures, cancer, progressive neurological deficits, or infection; Musculoskeletal, neurological, or cardiovascular conditions that may be worsened by exercise, according to healthcare professionals’ judgment, preventing participation in group physical activity; Cognitive impairment that prevents the older adult from answering interview questions and questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-7q2bh3r	Changes in fatigue after a exercise program in individuals with Long Covid and persistent fatigue	Recruiting	Intervention	2025-10-10	<NULL>	<NULL>	8388	Modifications in perceived and performance fatigability induced by a combined exercise intervention in patients with Long COVID and persistent fatigue	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-04	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-7q2bh3r	<NULL>	People who were diagnosed with COVID-19 by RT-PCR. Aged ≥18 years, of both sexes. Who report fatigue as a symptom for at least 12 weeks since the COVID-19 infection.	Pregnant women, hospitalized individuals, people with disabilities who are unable to perform the proposed tests and exercises. Individuals with cognitive impairments that prevent understanding or performing the tests, those with uncontrolled chronic diseases, and those with medical contraindications to physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-2vt25yh	Evaluation of the effect of Reiki therapy on blood sugar control in people with type 2 Diabetes who use insulin	Recruiting	Intervention	2025-10-10	<NULL>	<NULL>	8389	Effect of Reiki application on glycemic control in Insulin-dependent type 2 diabetic patients: a randomized clinical trial	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2025-03-24	Fundação Bahiana para Desenvolvimento das Ciências	Fundação Bahiana para Desenvolvimento das Ciências	https://ensaiosclinicos.gov.br/rg/RBR-2vt25yh	<NULL>	Patients with insulin-dependent type 2 diabetes mellitus over 18 years old, who have never undergone Reiki therapy	Patients who are unable to complete self-administered questionnaires those who do not agree to participate in the study and those who do not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:00
RBR-89sxw55	Realistic simulation for learning how to use pain medications	Not yet recruiting	Intervention	2025-10-09	<NULL>	<NULL>	8381	Enhancing clinical competencies in opioid management through realistic simulation: an experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	UNB Ceilândia - Faculdade de Ciências e Tecnologias em Saúde	UNICEPLAC - Centro Universitário do Planalto Central Apparecido dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-89sxw55	<NULL>	Volunteer students aged 18 or over and regularly enrolled in courses dealing with Perioperative Nursing.	Student volunteers who are nursing technicians or first responders, or those on sick leave.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-9wddjcd	The effect of Shock Wave Therapy in patients with Chronic Low Back Pain on pain intensity, muscle strength, functionality, and psychosocial aspects	Recruiting	Intervention	2025-10-09	<NULL>	<NULL>	8383	Effect of Shockwave Therapy on volunteers with Chronic Low Back Pain in the long-term management of physical, clinical-functional, and psychosocial sequelae	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-12	Centro de Ciências Biológicas e da Saúde da Universidade Estadual do Oeste do Paraná	Centro de Ciências Biológicas e da Saúde da Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9wddjcd	<NULL>	Volunteers of both genders; aged between 18 and 59 years; presenting with persistent and/or recurrent low back pain for more than three months, with physical characteristics compatible with mechanical etiology according to the evaluation and treatment guidelines proposed by the American College of Physicians and the American Pain Society; volunteers recruited from the patient flow of the Unioeste Physical Rehabilitation Center or invited through personalized outreach	Volunteers with non-mechanical low back pain (e.g., cancer-related pain); pregnant women; volunteers with a history of spinal surgery; neurological disorders; volunteers currently undergoing other types of physical therapy interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-29fn5rq	Paravertebral block to alleviate postoperative pain from robotic thoracic surgery: Comparison of the circulation changes caused by two different drugs used in the block, Dexamethasone and Dexmedetomidine	Recruiting	Intervention	2025-10-09	<NULL>	<NULL>	8384	Paravertebral Block in postoperative analgesia for robotic thoracic surgeries: Comparison of hemodynamic changes caused by the adjuvants Dexamethasone and Dexmedetomidine	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-06-02	Universidade do Estado do Rio de Janeiro	Gustavo Périssé Moreira Veras	https://ensaiosclinicos.gov.br/rg/RBR-29fn5rq	<NULL>	Age over 17 years; Classified as ASA 1 or 2; Classified as NYHA I or II; Thoracic surgeries by Robotics, in lateral position.	Pregnancy; Cognitive deficit and behavioral disorders; Use of stimulant or illegal drugs; Cardiopulmonary instability; Myocardial infarction or pulmonary embolism in the last 6 months; Cerebral, thoracic, or abdominal aneurysm; Previous thoracic surgery; Continuous home oxygen therapy; Autonomic disorders; Chronic use of alpha-adrenergic agonists; Inability to perform single-lung ventilation; Tumor in the trachea or vocal cords; Tracheal or bronchial stenosis; Use of anticoagulants; Chest wall infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-6zx5zcz	Electrical stimulation and combined training	Recruitment completed	Intervention	2025-10-09	<NULL>	<NULL>	8385	Whole-body neuromuscular electrostimulation and concurrent training: a pragmatic clinical trial with sedentary women of Maringá - PR	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-14	Universidade Cesumar	CliniSport	https://ensaiosclinicos.gov.br/rg/RBR-6zx5zcz	<NULL>	Women; aged 40–59 years; sedentary; residents of Maringá, Paraná; available for training; not enrolled in another intervention program; without clinical conditions that compromise participation; without pacemaker	Inscritas que não contemplarem os critérios de inclusão; participantes que apresentarem impossibilidade de continuidade no estudo ao longo das intervenções	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-5x7p5zy	The impact of Strength Training and Vitamin D on muscle loss and Obesity throughout aging	Recruitment completed	Intervention	2025-10-08	<NULL>	<NULL>	8379	Effects of Muscle Strength Training Combined with Vitamin D Supplementation in Elderly Individuals with Sarcopenic Obesity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade do Estado do Rio de Janeiro- Instituto de Educação Física e Desporto	Universidade do Estado do Rio de Janeiro- Instituto de Educação Física e Desporto	https://ensaiosclinicos.gov.br/rg/RBR-5x7p5zy	<NULL>	Elderly people, who are able to practice muscle strength training. Minimum age 60 years old. Both genders. Who have normal absorption of vitamin D, according to the age group studied. All persons must have signed the Informed Consent Form	People under 60 years of age. People, who despite being elderly, are not able to practice strength training due to cognitive or osteoarticular limitations. People with diseases that reduce or inhibit the absorption of vitamin D and bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-7zdb29p	Comparison of the efficiency of different materials used in the manufacture of dental aligners	Recruiting	Intervention	2025-10-08	<NULL>	<NULL>	8380	Comparative evaluation of the effectiveness of orthodontic aligners made with different types of materials	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7zdb29p	<NULL>	Mild to moderate Class I or II malocclusion (maximum 1/4 of Class II); age range between 18 and 35 years; both sexes; presence of all permanent teeth except the 3rd molars; mild to moderate degree of model discrepancy (from 2 to 6 mm); absence of skeletal crossbite	Severe periodontal diseases; lack of cooperation or adherence to treatment; presence of extensive prosthetic crowns; tooth shape anomalies; tooth fractures; active caries lesions; systemic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-4rg5yc8	Constipation and non-drug treatment alternative	Recruiting	Intervention	2025-10-07	<NULL>	<NULL>	8376	Auriculotherapy and Constipation in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-11	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4rg5yc8	<NULL>	Volunteers aged 60 or older; Mini Mental Health Exam score greater than 18 points for people without formal education and greater than 24 for those with formal education; diagnosis of functional constipation according to the Rome IV criteria	People with anatomically altered ears; signs in the ear that indicate infection, such as sores, redness, and sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-8c89q8n	Electrical Stimulation combined with Exercises to improve upper limb movements in people with Parkinson&apos;s disease	Recruiting	Intervention	2025-10-07	<NULL>	<NULL>	8377	Effect of Cerebellospinal Direct Current Stimulation (csDCS) associated with Kinesiotherapy on upper limb motor performance in individuals with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-27	Instituto de Neurologia Deolindo Couto	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8c89q8n	<NULL>	Adults with idiopathic Parkinson&apos;s Disease diagnosed using the Movement Disorders Society criteria; aged between 40 and 80 years; individuals with PD classified in stages 1 to 5 using the original Hoehn and Yahr (HY) scale; currently taking regular antiparkinsonian medication, with no change in the last month	Other associated neurological diseases; Cognitive impairment that impairs understanding of verbal commands, verified by the Montreal Cognitive Assessment (MoCA); Visual disorders that prevent evaluation and treatment; Limitation in moving the upper limbs that prevents evaluation and treatment; Use of DBS (deep brain stimulation) or other metal implants in the neck, head, or along the spine; Acute eczema in the areas where the electrodes are applied; History of epilepsy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-10h66vr4	Effectiveness of Bodybuilding combined with Vitamin D supplements on Cognition, Autonomy and Quality of Life in the elderly	Recruitment completed	Intervention	2025-10-07	<NULL>	<NULL>	8378	Effects of Muscle Strength Training combined with Vitamin D Supplementation on Executive Functions, Functional Autonomy and Quality of Life in the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade do Estado do Rio de Janeiro	Laboratório de Atividade Física e Promoção da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-10h66vr4	<NULL>	minimum age 60 years; healthy; sedentary; without the use of vitamin D supplementation	have some physiological impairment that inhibits or reduces the absorption of vitamin D; have any medical restrictions on taking Vitamin D supplementation; score lower than 26 on the Mini Mental State Examination; Do not sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-4b5n6yk	Impact of Multicomponent Training on physical performance, disease prevention, and quality of life in older adults	Recruiting	Intervention	2025-10-07	<NULL>	<NULL>	8382	Effects of Progressive Phase Multicomponent Training on physical fitness, antioxidant defense, DNA damage, and quality of life in sedentary older adults: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-15	Faculdade de Medicina	Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-4b5n6yk	<NULL>	People aged 60 to 80 years old of both sexes; sedentary; not practicing physical activities; enrolled in activities offered by the Open University for the Elderly, such as community gardening, oral health, basic computer science, literacy and literacy, craft activities, choir, basic English and guitar, including waiting list, for at least six months before the start of this research; practicing less than 150 minutes of moderate-intensity physical exercise per week, for at least three months	Being a smoker; consuming alcoholic beverages frequently; or taking antioxidant or pro-oxidant supplements in the last 6 months; inability to move from one point to another without personal or technical assistance; presenting any contraindication to carrying out the Multicomponent Training in Progressive Phases, such as injuries; muscle fractures; joint fractures in the last 3 months; terminal illness; serious cardiovascular disease; dementia; depression; Alzheimer&apos;s disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-2gcb7ht	Diet and pain in women with Temporomandibular Disorder (TMD)	Not yet recruiting	Observational	2025-10-06	<NULL>	<NULL>	8361	Dietary profile of women with chronic Temporomandibular Joint Disorder	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2gcb7ht	<NULL>	a pain complaint with a minimum intensity of 5, measured by a numerical pain scale ranging from 0 (no pain) to 10 (worst possible pain), with the main pain in the temporomandibular joint region and no previous treatment in the last three months; the healthy group will consist of women without a diagnosis of temporomandibular dysfunction and without a history of facial pain	women with previously diagnosed incapacitating cognitive, psychological or neurological alterations; other chronic pain disorders; abuse of licit drugs or alcoholic beverages; use of illicit drugs; heart disease; pregnant and lactating women will be excluded; volunteers with loss of five or more dental elements; ill-fitting prostheses; severe periodontal disease; odontalgia; intra- or extra-oral lesions that compromise masticatory function; food intolerances; diabetes mellitus or other systemic conditions that may lead to food restriction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-2vbfbh9	Animated infographic to guide hospital discharge of elderly patients with urinary catheters: a quasi-experimental study	Data analysis completed	Intervention	2025-10-06	<NULL>	<NULL>	8362	Animated infographic for hospital discharge of elderly people with indwelling urinary catheter: a quasi-experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-13	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2vbfbh9	<NULL>	Be 60 years of age or older, undergo urological surgery and keep the urinary catheter after hospital discharge	Elderly individuals who have used a urinary catheter at some point, as it is assumed they already know how to take care of themselves. Also, elderly individuals who are not cognitively capable of answering the questions in the data collection instrument	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-82c8gr7	Aromatherapy foot bath: a randomized trial for Depression, Anxiety, and Minor Disorders	Not yet recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8363	The use of Complementary Integrative Practices, PIC&apos;s, in the municipality of Londrina, UEL, city hall of Londrina	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-82c8gr7	<NULL>	trabalhadores da saúde que atuam direta e indiretamente com o cuidado do paciente, que atuam em um hospital terciário	Retired workers or those with planned and unplanned absenteeism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-2h8ng8b	Effects of the Pilates method on cardiorespiratory system of Hypertensive elderly individuals	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8364	Cardiorespiratory effects of the Pilates method in Hypertensive elderly individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-12	Universidade Federal de São Paulo	Physio&amp;Pilates Guarujá LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2h8ng8b	<NULL>	Hypertensive elderly individuals with a medical report; of both genders; Hypertension controlled by medication; sedentary; with medical clearance to practice physical exercises; without injuries that compromise the training program; who agree to volunteer for the research	Elderly individuals with medication changes during the experimental period; with an attendance rate lower than 75% in the training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-4hfkfdn	Mindfulness in School: Immediate Effects on Attention in Middle School Students	Recruitment completed	Intervention	2025-10-06	<NULL>	<NULL>	8365	Mindfulness in School: Immediate Effects on Attention in Middle School Students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-11	Univinte Centro Tecnologico Eireli	Univinte Centro Tecnologico Eireli	https://ensaiosclinicos.gov.br/rg/RBR-4hfkfdn	<NULL>	Students enrolled from the 6th to the 9th grade of Elementary School II at the Technical School of Commerce of Tubarão aged between 10 and 15 years present on the days of experimental activities prior authorization from legal guardians for participation in the study neurotypical and neurodivergent students without distinction or differential analysis	Students absent on any of the three days of the proposed interventions students without prior authorization signed by their legal guardians	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-8fdcbc3	Body temperature-sensitive hydrogel based on green propolis for the auxiliary treatment of periodontal diseases	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8366	Thermosensitive Green Propolis hydrogel for use as an adjunct to periodontal treatment: clinical and laboratory analysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8fdcbc3	<NULL>	Both genders; with a minimum age of 18 years and no maximum age limit; minimum of 14 teeth present in the mouth (excluding third molars and teeth indicated for extraction); diagnosis of periodontitis stage 2 or 3 and grade B or C (at least 30% of teeth with at least one site with probing pocket depth (PPD) and clinical attachment level (CAL) equal or higher than 5 mm and bleeding on probing); systemically healthy patients; patients diagnosed with Diabetes Mellitus	Smoking, pregnancy; total edentulism; recent periodontal treatment; recent use of antibiotics; patients who refused to sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-5r9pnrw	Effect of a muscle balance protocol on the knees of soccer players – a randomized controlled clinical trial	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8367	Evaluation of the effects of a muscular balance protocol on lower limbs of football athletes – a controlled clinical trial randomized	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-19	Universidade Federal de Alfenas	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5r9pnrw	<NULL>	Participants will be included, men between the ages of 13 and 20, football players from the city of Alfenas.	Participants under the age of 13 and over the age of 20 who are not soccer players will be excluded from these studies. Participants with a history of orthopedic injuries to the lower limbs in the last six months prior to screening will be excluded; presence of diseases and/or dysfunctions of any nature that interfere with the movements of the upper and/or lower limbs; dermatological lesions such as ulcers and blisters on the feet; individuals with infectious diseases, myopathies and recognized collagen disorders; those with neurological injuries and rheumatological diseases that affect the trunk; and those who do not wish to participate and do not agree to sign the ICF will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-3tqb39m	Home Exercise Training with or without supervision for women undergoing treatment for Breast Cancer	Recruitment completed	Intervention	2025-10-06	<NULL>	<NULL>	8368	Online Supervised and Non-Supervised Physical Training for Breast Cancer survivors and its impact on strength, cardiorespiratory fitness, body composition, fatigue, and adherence: a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-30	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher da Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3tqb39m	<NULL>	Women up to 65 years old; previous breast cancer diagnosis; adjuvant or neoadjuvant chemotherapy performed; exclusive adjuvant endocrine therapy between 6 and 36 months; no evidence of disease	Presence of metastasis; inability to answer questionnaires; inability to perform the initial physical assessment; lack of physical condition to perform exercises; unavailability to participate in the online training program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-65cdkc5	Teeth bleaching and its effects on sensitivity and people&apos;s well-being	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8369	Dental Bleaching: tooth sensitivity, psychosocial impact and impact on oral health-related quality of life using different desensitization protocols: randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-07-03	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-65cdkc5	<NULL>	Male or female patients; aged 18 to 40 years; patients without systemic diseases (metabolic, immunological, and heart diseases); oral condition without periodontal diseases; at least two canines with shade C2 or darker, assessed using the VITA classical A1-D4® scale; six maxillary anterior teeth free of restorations on the palatal and buccal surfaces; sound enamel with no pathological, physiological, or drug-induced alterations	Volunteers with orthodontic appliances; severe crowding; presence of intrinsic stains (tetracycline staining, fluorosis, non-vital teeth); use of anti-inflammatory drugs; smokers; alcohol consumers; pregnant or breastfeeding women; participants who have already undergone a bleaching procedure; participants with bruxism or significant oral pathologies; participants with dentin exposed on the incisal portion of anterior teeth; non-carious cervical lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-4zvmwzd	Using less fluid in daily Hemodiafiltration may remain safe, support good metabolic control, and reduce water waste	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8370	Effects of reduced Dialysate flow on dialysis efficiency, metabolic control, water consumption, and safety in patients undergoing in-center short daily Hemodiafiltration a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-10	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4zvmwzd	<NULL>	Individuals of both genders; age over 18 years and under 75 years; undergoing daily Hemodiafiltration due to stage five chronic kidney disease; clinically stable in the last three months; adherence to treatment of at least eighty percent in the last three months; written informed consent provided	Presence of clinically relevant acute infectious diseases; active cancer; recent cardiovascular instability such as myocardial infarction or decompensated heart failure; clinical conditions that may interfere with result interpretation or treatment adherence; severe psychiatric conditions that may compromise adherence or result interpretation; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-9g9b779	Speed strength training and its effects on heart and brain health in people with Parkinson&apos;s disease	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8371	Acute effect of potent strength training on cardiovascular parameters and neurotrophic and inflammatory biomarkers in patient with Parkinson&apos;s disease of mild to moderate	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-11	Hospital Universitário Walter Cantídio da Universidade Federal do Ceará	Hospital Universitário Walter Cantídio da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9g9b779	<NULL>	Men and women; diagnosed with Parkinson&apos;s disease according to MDS-UPDRS criteria; stages I to III on the modified Hoehn &amp; Yahr scale; no changes in medication regimen for at least 4 weeks; literate; able to perform basic activities of daily living independently with a Schwab and England scale score of at least 80%; age equal to or greater than 40 years	Body mass index greater than 40 or less than 20; diagnosis of specific diseases such as Crohn&apos;s disease, ulcerative colitis, multiple sclerosis; clinical and psychological conditions that may interfere with participation or study results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-10dxtj89	Short-term Garlic Supplementation Enhances Salivary Antioxidant Enzyme Activity Following Exhaustive Exercise in Physically Active Middle-aged Men	Data analysis completed	Intervention	2025-10-06	<NULL>	<NULL>	8372	Investigation the Effect of Garlic Supplementation on Salivary Antioxidants Changes After an Exhaustive Exercise in Middle-aged Athlete Men	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-07	University of non-governmental Qadir	University of non-governmental Qadir	https://ensaiosclinicos.gov.br/rg/RBR-10dxtj89	<NULL>	Physically active men playing soccer 2 to 3 sessions per week; non-smokers; free from supplement use, chronic illness, injury, or oral infections	Inability or unwillingness to perform the exercise protocol to exhaustion; failure to complete the full supplementation period; engagement in vigorous or unaccustomed physical activity within 48 hours prior to testing sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-3ccp383	Aesthetic performance and tolerance evaluation for Profhilo® applications in the treatment of wrinkles and laxity skin of the neck	Terminated	Intervention	2025-10-06	<NULL>	<NULL>	8373	Aesthetic performance and tolerance evaluation of Profhilo® injective intradermal treatment for the skin roughness and laxity of the neck	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2024-03-22	For Trials Pesquisa Clínica Ltda	IBSA Farmaceutici Italia S.r.l.	https://ensaiosclinicos.gov.br/rg/RBR-3ccp383	<NULL>	Female sex; 35-65 years; 3-4 neck roughness/laxity grade according to a clinical reference scale; asking for neck laxity and roughness restoration; available and able to return to the study site for the post-procedural follow-up examinations; accepting to not change their habits regarding food, physical activity, cosmetic and cleansing products for the neck; accepting to not expose their neck to strong UV irradiation (UV session, or sun bathes) during the entire duration of the study, without appropriate sun protection; accepting to sign the informed consent form	Pregnancy; lactation; smoking; alcohol abuse or drug use; non-menopausal volunteers who do not want to use adequate methods of contraception to avoid pregnancy during the study; non-menopausal volunteers who do not want to undergo a pregnancy test at T1 (before the 1st injection) and T3 (1 month after the 1st injection and before the 2nd injection); variation in body mass index (BMI) (± 1) during the study period; performing aesthetic treatments for the skin of the neck (dermal implants, surgical lifting, botulinum toxin, laser, chemical peels) 6 months before the start of the study; who have had permanent fillings in the past; changes in eating habits, physical activity, cosmetic and neck cleaning products during the month preceding the tests; sensitivity to the product or its ingredients (to be questioned by the investigator during the baseline visit); volunteers whose poor adherence to the study protocol is predictable; participation in a similar study concurrently or in the last 9 months; dermatitis; presence of dermatological diseases in the tested area, such as injuries, scars, malformations; recurrent facial/lip herpes; significant clinical conditions in the tested area (e.g. active eczema, psoriasis, severe rosacea, scleroderma, local infections, severe acne); diabetes; endocrinological diseases; liver dysfunctions; kidney dysfunctions; cardiac dysfunctions; lung diseases; cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-8mn88b2	Pollutant gas emissions in the treatment of Kidney Stones by External Shock Wave therapy compared to Laser Stone Fragmentation	Data analysis completed	Intervention	2025-10-06	<NULL>	<NULL>	8374	Carbon emission in the treatment of Ureteral Stones by Extracorporeal Shock Wave Lithotripsy compared to Transureteroscopic Ureterolithotripsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-06	University of São Paulo	University of Pittsburgh	https://ensaiosclinicos.gov.br/rg/RBR-8mn88b2	<NULL>	Consecutive patients aged over 18 years with symptomatic ureterolithiasis; who underwent primary lithotripsy at the Endourology Unit or the Emergency Department of the Hospital das Clínicas, Faculty of Medicine, University of São Paulo	Patients undergoing retreatment; pregnant women; those unable to continue treatment at the Institution; patients with ureteral stones smaller than 5 mm or larger than 15 mm; patients with active urinary tract infection or with coagulopathies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-4njj56p	Comparison of different Selective Laser Trabeculoplasty (SLT) protocols in the treatment of Open Angle Glaucoma and Ocular Hypertension	Recruiting	Intervention	2025-10-06	<NULL>	<NULL>	8375	Performance of Selective Laser Trabeculoplasty (SLT) protocols - Enhanced and Transscleral - in the treatment of patients with Open Angle Glaucoma and Ocular Hypertension: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4njj56p	<NULL>	Age over 40 yo; Both sexes; Clinical indication for bilateral SLT; Diagnosis of ocular; hypertension or open angle glaucoma (mild to moderate); Open angle on gonioscopy; Baseline intraocular pressure equal to or greater than 16 mmHg	Gonioscopy alterations; Previous intraocular surgery or laser; History of ocular trauma; Advanced OAG; Other types of glaucoma; Associated ophthalmological diseases; Unreliable data; Participants in other clinical trials	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-6k7gfy4	Evaluation of the effects of Orthostatism in critical patients: a randomized double-blind clinical trial	Not yet recruiting	Intervention	2025-10-05	<NULL>	<NULL>	8357	Effects of Orthostatism in Comatose patients admitted to the ICU: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-20	Universidade Federal do Delta do Parnaíba	Hospital Estadual Dirceu Arcoverde - HEDA	https://ensaiosclinicos.gov.br/rg/RBR-6k7gfy4	<NULL>	Patients admitted to the intensive care unit (ICU); of both sexes; aged 18 or over and 65 or under; who are on invasive mechanical ventilation (IMV) for at least twenty-four hours; in a coma of neurological or metabolic origin; with hemodynamic stability for carrying out the intervention	The study will not include patients under 18 years of age; patients with cardiac alterations confirmed by electrocardiogram (ECG); bronchopleural fistula; deep vein thrombosis; thrombocytopenia (below 50,000); body temperature above 37.8°C; orthopedic fractures in the lower limbs; orthopedic alterations that limit orthostatism; spinal cord injury; significant pressure injury in the calcaneus; use of intra-aortic balloon pump (IABP); intracranial pressure (ICP) monitoring catheter and/or external ventricular shunt (EVD); use of vasoactive drugs in high doses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-9gh9ht7	Immediate effect of Laser on women without voice complaints	Recruitment completed	Intervention	2025-10-05	<NULL>	<NULL>	8358	Immediate effect of Low-Intensity Laser in Vocally Healthy Women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-15	CEPRE Centro de Estudos e Pesquisas em Reabilitação ”Prof. Dr. Gabriel O.S. Porto”	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9gh9ht7	<NULL>	Female subjects; aged between 18 and 45 years old; with no history of voice complaints	"Women who report changes in the gland thyroid or hormonal changes; being in menopause or
have a cold or upper airway allergies on the day speech therapy intervention or have contraindications for phototherapy according to the manufacturer&apos;s manual and specific literature; photosensitivity; pregnancy; glaucoma; injury no diagnosis on or near the area to be irradiated; infection at the site application; history of cancer; use of a pacemaker or other implant electronic"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-9qv5gd7	Metabolic profile and autonomic and cardiovascular recovery in hypertensive individuals under the acute effect of resveratrol	Not yet recruiting	Intervention	2025-10-05	<NULL>	<NULL>	8359	Acute effect of resveratrol on the metabolic profile and on autonomic and cardiovascular recovery in individuals with non-communicable chronic diseases	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-08-03	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9qv5gd7	<NULL>	Volunteers must be between 18 and 59 years of age. There will be no gender restrictions, however, study participants will be allocated to different groups based on male or female gender. Participants must not have skeletal muscle injuries	Patients with cardiorespiratory, neurological and other known impairments that prevent the subject from performing the procedures. Women will not be included in the period of 10-15 days and 20-25 days after the first day of the menstrual cycle to avoid influence of the luteal and follicular phases of the menstrual cycle. Participants will be instructed not to drink alcoholic beverages or consume substances containing resveratrol (for example, teas, açaí, chocolate, whole grape juice, red or white wine and soft drinks). Do not perform high-intensity training for 24 hours prior to the evaluation. Consumption of grape juice, caffeine, alcoholic beverages or any other type of substance prior to the procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-10y57ftt	The effects of acupuncture with electrical stimulation or manual on cerebral blood flow in individuals with chronic pain	Recruitment completed	Intervention	2025-10-05	<NULL>	<NULL>	8360	The effects of Electrostimulation or Manual Acupuncture at he gu and taichong acupoints on the hemodynamics of the prefrontal cortex and activity of the autonomic nervous system in individuals with Chronic Pain: a study with infrared spectroscopy and photoplethysmography	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-10y57ftt	<NULL>	Individuals of both sexes; living in the Greater Florianópolis region, aged between 18 and 79 years; diagnosed with chronic pain for at least the last three months and undergoing pharmacological treatment prescribed by their attending physician will be included in this study; Patients who agree to participate in the study must sign an Informed Consent Form (ICF) and meet the criteria required above	Individuals with untreated immunosuppressive; oncological; infectious; renal; hepatic; gastrointestinal or psychiatric diseases; using anti-inflammatory drugs or drugs that affect the inflammatory process one week before blood collections; pregnant or lactating women; patients with herniated discs with motor deficit; post-surgery spine or rheumatic diseases, through medical diagnosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-72wsmt7	Study of the retinal structure in patients with Autism Spectrum Disorder	Recruiting	Observational	2025-10-03	<NULL>	<NULL>	8351	Structural retinal evaluation with optical coherence tomography in patients with Autism Spectrum Disorder	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-72wsmt7	<NULL>	Diagnosis of Autism Spectrum Disorder according to the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders criteria (for the study group) or absence of Autism Spectrum Disorder criteria (for the neurotypical control group); Age between 7 and 20 years; Refractive error of less than 6 spherical diopters and less than 3 cylindrical diopters in absolute values; Best-corrected visual acuity of 0.5 decimal or better; Absence of a history or signs of other ocular diseases; Absence of other general health conditions that could affect Optical Coherence Tomography measurements; Ability to collaborate to obtain high-quality and reliable Optical Coherence Tomography exams	Non-verbal patients with Autism Spectrum Disorder; Patients with retinal alterations identified on fundoscopy that could interfere with the results of the Optical Coherence Tomography exam	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-6c7styj	Topical Metformin Effectiveness in Melasma Treatment	Recruitment completed	Intervention	2025-10-03	<NULL>	<NULL>	8352	Evaluation of the efficacy of topical metformin in the treatment of melasma	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-05-05	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6c7styj	<NULL>	Women with facial melasma over 18 years of age; Users of SPF 50 sunscreen	Women under 18 years of age; pregnant or breastfeeding women; women undergoing hormone replacement therapy or treatments with photosensitizing drugs such as tetracycline, spironolactone, phenytoin, and carbamazepine; hypersensitivity to the formulations used in the study; bleeding disorders; skin conditions (facial warts, active or recurrent herpes simplex, seborrheic, atopic, or eczematous dermatitis/dermatosis); history of keloids or hypertrophic scars; immunocompromised patients; patients undergoing chemotherapy or radiotherapy; and patients with a history of using any other therapy for the treatment of melasma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-78dvhgs	Analysis of the stability of Implants with different macrogeometries	Not yet recruiting	Intervention	2025-10-03	<NULL>	<NULL>	8353	Comparative analysis of the initial stability of Dental Implants with different macrogeometries: in vivo study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Márcio de Carvalho Formiga	Universidade do Vale do Itajaí	https://ensaiosclinicos.gov.br/rg/RBR-78dvhgs	<NULL>	18 years old or more; systemic healthy; no contraindications for implant surgeries; no need for bone grafts; with at least one site in the need for implant supported rehabilitation; good oral health conditions;	smokers; diabetes; patients with history of use of bisphosphonates oral or endovenous; patients with the need for bone grafts; any type of systemic condition that would contraindicate oral surgeries;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-5spkfw2	Impact of different Materials on the gum of teeth with Lesions near the gums that are not caused by Caries	Recruiting	Intervention	2025-10-03	<NULL>	<NULL>	8354	Impact of different Composite Resins on the Periodontal response of teeth with Non-Carious Cervical Lesions: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5spkfw2	<NULL>	Participant must be at least 18 years old; both sexes; must have a clinical diagnosis of non-carious cervical lesion with a cavity depth between 1.0 mm and 2.0 mm, located on the buccal surface of at least three premolar teeth; teeth must be non-mobile; participants must be in good general health (ASA I: a normal healthy patient; and ASA II: a patient with mild systemic disease without significant functional limitations); must maintain acceptable oral hygiene according to the Simplified Oral Hygiene Index (OHI-S); must have at least 20 teeth in occlusion; the cavosurface margin must involve more than 50% enamel	Participants with a history of allergy to any material used in the study; smoking participants; participants requiring gingival grafting in the region of the teeth to be treated; use of orthodontic appliances; severe or chronic periodontitis (evidenced by pocket depth greater than 4 mm with bleeding on probing and clinical attachment loss greater than 3 mm in more than 4 teeth); teeth with Miller Class III or IV gingival recession; severe bruxism (characterized by significant masticatory muscle pain, temporomandibular joint pain, or extreme tooth wear); pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-88hg3bh	Acupuncture on the control of nausea and vomiting in patients undergoing Bariatric Surgery in a private hospital in São Luís-Ma	Not yet recruiting	Intervention	2025-10-03	<NULL>	<NULL>	8355	Effect of acupuncture on the control of nausea and vomiting in patients undergoing Bariatric Surgery in a private hospital in São Luís-Ma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-88hg3bh	<NULL>	Patients undergoing bariatric surgery; aged 18 or over; with assessment of postoperative nausea and vomiting will be included in the study	Those who do not consent to participate in the research; contraindications to acupuncture techniques such as rash at the point of stimulation on the skin or systemic infection; severe obstructive sleep apnea syndrome; uncontrolled systemic diseases of the heart, lung, kidney or liver; coagulation disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-89c2sqh	Evaluation of the effects of Magnesium and Inositol Supplementation on sleep quality, Anxiety and quality of life of health students	Recruitment completed	Intervention	2025-10-03	<NULL>	<NULL>	8356	Evaluation of the effects of Magnesium and Inositol Supplementation on sleep quality, Anxiety and quality of life of health students at a university in southern Brazil: a randomized controlled crossover clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-06-03	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-89c2sqh	<NULL>	healthy students; both genders; between 18 and 30 years old; studying medicine; from the University of Southern Santa Catarina; without diagnosed disease and/or under treatment	students with immunosuppressive diseases; oncological diseases; infectious diseases or fever; epileptic diseases; diagnosed with depression, pregnant and/or lactating women, students already taking supplements; with kidney or liver damage; illicit drugs, stimulants, centrally acting medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:53
RBR-2n395mz	Physical Exercise during hemodialysis: the benefits for blood pressure, blood pressure, and mental health	Data analysis completed	Intervention	2025-10-02	<NULL>	<NULL>	8345	Effect of different types of Physical Exercises on dialysis efficiency, cognitive and physical aspects: a randomized controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	UNIVERSIDADE SÃO JUDAS TADEU - AMC SERVIÇOS EDUCACIONAIS S/C LTDA	UNIVERSIDADE SÃO JUDAS TADEU - AMC SERVIÇOS EDUCACIONAIS S/C LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2n395mz	<NULL>	Having Chronic Kidney Disease; of either sex; aged 18 or over; undergoing stable hemodialysis for at least three months	Possess any psychological disorders that make it impossible to understand the proposed study; present amputation and/or disability of lower limbs; pregnant women; high cardiovascular risk; changes in hemodialysis access; musculoskeletal complications; be a carrier of the human immunodeficiency virus (HIV); have any other relevant factor identified by the researchers that affects physical activity; have participated in any physical exercise program in the last three months, such as weight training and gymnastics, systematically	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-6kd4f39	Fixing the galea aponeurotica may be an advantageous strategy compared to conventional closure in Pterional Craniotomies in elective surgeries	Recruiting	Intervention	2025-10-02	<NULL>	<NULL>	8346	Subgaleal anchorage versus conventional closure in patients undergoing pterional craniotomy in elective surgeries: a randomized controlled clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-02-01	Empresa Brasileira de Serviços Hospitalares	Hospital Universitário Getúlio Vargas da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-6kd4f39	<NULL>	Patients who will undergo Pterional Craniotomy, regardless of the etiology of the lesion to be operated on; both sexes; age over 18 years; level of consciousness adequate to assess postoperative pain	Patients who have already undergone a previous Craniotomy; patients who have infection or trauma at the same incision site prior to Surgery; patients who chronically suffer from Facial Pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-7yrysy5	Assessment of the presence of protection against yellow fever in children and adults after administration of reduced doses of the 17dd-yellow fever vaccine	Recruiting	Observational	2025-10-02	<NULL>	<NULL>	8347	Observational study of the long-term duration of humoral and cellular immunity in children and adults after primary yellow fever vaccination 17dd using a fractional dose (1/5 of the standard dose)	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Instituto René Rachou da Fundação Oswaldo Cruz	Instituto Nacional de Infectologia Evandro Chagas da Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-7yrysy5	<NULL>	Female and male participants; who participated in the study “Humoral and cellular immunity in children and adults subjected to 17DD yellow fever primary vaccination with a fractional dose,” conducted in the state of São Paulo in 2018; who had a negative yellow fever seroneutralization result prior to vaccination in 2018; participants must be at least 10 years old in 2025; participants must agree to provide their name, address, telephone number, and other personal information to allow contact; participants must be able to understand and sign the assent form or the informed consent form	Participants who received another dose of the yellow fever vaccine after 2018 with confirmation in the immunization record; participants diagnosed with autoimmune diseases or neoplasms after 2018, or who are using immunomodulatory drugs; participants presenting with a febrile illness at the time of sample collection; participants who have received the dengue or cholera vaccine; participants who were diagnosed with yellow fever after vaccination in 2018	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-57dgft9	An early physical therapy program for anterior knee pain	Recruiting	Intervention	2025-10-02	<NULL>	<NULL>	8348	Effectiveness of early physical therapy compared to delayed physical therapy for patients with patellofemoral pain: a multicentre randomized clinical trial	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-20	Universidade Estadual Paulista Julio de Mesquita Filho	Faculdade de Ciências e Tecnologica da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-57dgft9	<NULL>	Young adult males and females; aged 18-35 years old; with anterior knee pain when performing at least two functional activities; self-report recent- (4 to 12 weeks) or late-onset (more than 6 months) pain; insidious-onset pain in one or both knees; worst pain level in the last 4 weeks of at least 3 on a 0-10 numeric pain scale	Clinical evidence of any other knee disorder/condition; history of recent lower back or limb injury (less than 6 months); recent engagement to a physical therapy program (less than 1 month); history of knee or lower limb surgery; low back pain with leg pain; inability to read or understand english, portuguese, or french-speaking Belgian; presence of heart or neurological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-10tfg466	The Passage of Force between the two sides of the body induced by Palmar Grip Muscle Fatigue in right-handed women: a controlled experimental study	Not yet recruiting	Intervention	2025-10-02	<NULL>	<NULL>	8349	Motor Overflow Induced by Handgrip Fatigue in right-handed women: a controlled experimental study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10tfg466	<NULL>	Healthy volunteers; female; aged between 18 and 30; with motor preference for the right upper limb	Severe pain; discomfort during testing; inability to perform the experimental protocol as instructed; voluntary withdrawal; participants who fail to achieve at least 70% of maximum voluntary isometric contraction (MVIC) in the post-test measurement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-9cxtns2	Influence of suture on the fixation of a volume-stable collagen matrix in multiple root coverage - A randomized clinical trial	Recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8335	Influence of the suture technique on the tissue volume obtained with a volume-stable collagen matrix in gingival recessions – a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-04-01	Faculdade de Odontologia da Universidade de São Paulo	Geistlich Pharma AG	https://ensaiosclinicos.gov.br/rg/RBR-9cxtns2	<NULL>	Individuals of both sexes. Aged 18 years or older. Presence of RT1 gingival recessions in incisors, canines, or premolars in the maxilla or mandible. Multiple and adjacent recessions in three teeth with a depth difference of no more than 2 millimeters between the recessions. Presence of keratinized tissue greater than or equal to 1 millimeter in the involved teeth. Visible cemento-enamel junction	Active periodontal disease or history of periodontal disease in the candidate teeth. Malpositioned teeth in the recipient area including buccal displacement, rotation, or occlusal trauma. Presence of root caries. Non-carious cervical lesions or cervical step greater than 1 millimeter. Smoking more than 10 cigarettes per day. Pregnant or lactating women. Systemic diseases that may interfere with tissue healing such as diabetes mellitus or acquired immunodeficiency syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-452bhzf	Prophylaxis of postpartum hemorrhage in high-risk patients: a comparison between Carbetocin and Oxytocin. The PHARCO Study	Not yet recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8336	Study on the prevention of postpartum hemorrhage: Carbetocin vs Oxytocin in high-risk patients	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2025-10-15	Hospital da Mulher Professor Doutor José Aristodemo Pinotti da Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-452bhzf	<NULL>	Women; aged 18 years or older; receiving magnesium sulfate at the standard dose (intravenously with a loading dose of 4 g, followed by a maintenance dose of 1 to 2 g/hour); with an indication for delivery by vaginal birth or cesarean section	Women ;under 18 years of age; who decline to participate in the study; with a concurrent diagnosis of sepsis or intra-amniotic infection/chorioamnionitis; whose magnesium sulfate maintenance dose is not between 1–2 grams per hour; who received uterotonic medication more than 5 minutes after delivery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-632fptj	Remote programming for bone anchored hearing aid users	Recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8337	Remote Assist for bone anchored hearing aid users	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-12	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo (HRAC-USP)	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo (HRAC-USP)	https://ensaiosclinicos.gov.br/rg/RBR-632fptj	<NULL>	Adult users of bone-anchored hearing aids with the Baha Connect or Baha Attract system; Minimum and maximum age without limit; both genders; minimum three months of experience using the device; access to a smartphone compatible with the Remote Assist app; availability to participate in the scheduled in-person and remote sessions	Individuals with intellectual disabilities or psychiatric disorders that prevent autonomous use of the application; lack of connectivity or compatible devices; diagnosis of hearing loss not indicated for use of the Baha system; non-adherence to the remote protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-3gx2h7f	Effects of caffeine chewing gum on physiological and 50-m time-trial freestyle swimming performance	Recruitment completed	Intervention	2025-10-01	<NULL>	<NULL>	8338	Effect of caffeine chewing gum supplementation on interval training and freestyle swimming performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-14	Universidade Federal de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3gx2h7f	<NULL>	Be at least 18 years of age; to be of the masculine gender; regularly training and competing in swimming for at least 5 years; being free from chronic diseases; self-report of not regularly using any substance that could interfere with metabolic responses; self-report of not regularly using any nutritional supplement containing intracellular buffers	Possess a physical limitation that makes them unable to swim; engage in physical activity within 24 hours preceding the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-2x24xpw	The effect of practicing mental and physical tasks performed at the same time on the ability to adjust gait in older adults with history of falls: a blinded randomized clinical trial	Not yet recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8339	The effect of cognitive-motor training on adaptive locomotion in older adults with history of falls: a blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2x24xpw	<NULL>	Men and women; age between 65 and 80 years; intellectual capacity to understand verbal commands and to perform tasks; at least one fall in the last six months; ability to stand and walk independently without the use of assistive devices; present a MiniBEST score below the cutoff point for age-adjusted risk of falling	Cognitive deficits, such as Alzheimer&apos;s Disease; color blindness or other visual impairment not corrected by glasses or contact lenses; severe uncontrolled musculoskeletal, sensory, neurological or cardiovascular problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-33yz6xw	Effects of Video Games on the health of older adults	Not yet recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8340	Effects of Active Video Games on the health of older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora, campus Governador Valadares	https://ensaiosclinicos.gov.br/rg/RBR-33yz6xw	<NULL>	Individuals aged 60 years or older; of both sexes	Participants who have a medical diagnosis of psychological disorders (T.), for example: Social phobia; Bipolar disorder; Autism spectrum disorder (ASD); Personality disorder; Psychotic disorder; and Panic disorder. Neurodegenerative diseases, for example: Alzheimer&apos;s; Dementia; Parkinson&apos;s; Down syndrome; Multiple sclerosis; Autoimmune rheumatic disease; Hydrocephalus; Epilepsy; and Alcohol and/or illicit drug abuse. Cardiometabolic diseases, for example: Diabetes mellitus (type 1); Coronary artery disease; Stroke; and Chronic kidney disease. Lung diseases, for example: Chronic obstructive pulmonary disease; Pneumonia; Tuberculosis; and Bronchitis. Presenting symptoms suggestive of cardiovascular disease, such as: Syncope; Dyspnea; Tachycardia; and Angina. Presenting symptoms suggestive of neurodegenerative diseases, such as: persistent memory loss of recent events or important information; deficits in speech fluency or sentence construction; difficulty solving everyday problems or making simple decisions; difficulty recognizing people, objects, or places; irritability or aggression without apparent cause; difficulty performing simple motor tasks; loss of coordination and balance without apparent cause. Continuous use of psychotropic medications, such as antidepressants, anxiolytics, mood stabilizers, and/or stimulants, for a period of less than three months, an interval considered necessary for the body to adapt and minimize the initial effects of these medications. Introducing, throughout the intervention protocol, complementary therapies not initially planned, such as psychological and/or psychiatric interventions; use of medications that may influence the outcomes of interest; and the practice of physical or digital exercises that may impact the variables analyzed. Possess psychological or cognitive limitations; and/or osteoarticular conditions that prevent the practice of physical activity (PA) and/or medical impediment to the practice of PA	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-4c9jzv4	Assessment of functional capacity and screening for Sarcopenia in primary care	Recruiting	Observational	2025-10-01	<NULL>	<NULL>	8341	Health in motion: UBS+Active	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Jataí	Secretária Municipal de Saúde de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-4c9jzv4	<NULL>	People who are or are not participating in specific health care programs; present in the waiting room of the primary health care unit; or referred by a physician; minimum age of 18 years; both sexes	Individuals who withdraw from the assessments; present clinical or intellectual limitations that prevent the performance of functional tests; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-2h8vyrz	Effects of Respiratory Exercise on Respiratory muscle strength and lung volumes in patients with Chronic Kidney Disease in the Non-Dialysis Stage: a randomized clinical trial	Recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8342	Effects of Progressive Inspiratory Muscle Training on respiratory muscle strength and lung volume variation in patients with Chronic Kidney Disease in the Non-Dialysis Stage: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-09	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2h8vyrz	<NULL>	Patients over 18 years of age, of both sexes, diagnosed with chronic kidney disease on non-dialysis treatment (stage 3 to 5 non-dialysis) with cognitive capacity to perform evaluative procedures and stable from a clinical and hemodynamic point of view will be included	Individuals who have respiratory diseases that alter pulmonary mechanics (asthma, chronic obstructive pulmonary disease, bronchiectasis, history of tuberculosis), are presenting with an active stage infectious disease, and decompensated heart disease will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-6cdhmgx	Strategies for Dealing with Stress in Military Police Officers	Not yet recruiting	Intervention	2025-10-01	<NULL>	<NULL>	8343	Mindfulness as Coping Strategies for Burnout Syndrome in Military Police Officers: A Research Proposal for the 8th Battalion of the PMDF	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2025-10-01	Centro de Estudos Avançados e Multidisciplinares da Universidade de Brasília	Departamento de Educação e Cultura/Instituto Superior de Ciências Policiais	https://ensaiosclinicos.gov.br/rg/RBR-6cdhmgx	<NULL>	Active police officers; no history of serious mental disorders; agree to participate in all stages of the study	Reserve police officers; history of severe mental disorders such as bipolar disorder, schizophrenia, or other diagnosed psychotic disorders; refusal to participate in the study or failure to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-9835rf8	How Pharmaceutical Intervention Can Help Dialysis Patients Resolve Medication Issues: A Clinical Study	Recruitment completed	Intervention	2025-10-01	<NULL>	<NULL>	8344	Pharmaceutical Intervention in Medication-Related Problems in Patients Undergoing Peritoneal Dialysis and Hemodialysis: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-13	Universidade Estadual Paulista Julio de Mesquita Filho-Faculdade de Medicina-Câmpus de Botucatu.	Universidade Estadual Paulista Julio de Mesquita Filho-Faculdade de Medicina-Câmpus de Botucatu.	https://ensaiosclinicos.gov.br/rg/RBR-9835rf8	<NULL>	Individuals of both genders; aged 18 years or older; diagnosed with stage 5 Chronic Kidney Disease; undergoing Peritoneal Dialysis or Hemodialysis for at least 3 months; legally capable of signing the Informed Consent Form (ICF)	Cognitive impairment that prevents understanding the study or participating in the pharmaceutical consultations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-6zfzs4j	Comparison of the effect of three Benznidazole formulations for the treatment of Chagas Disease	Data analysis completed	Intervention	2025-09-30	<NULL>	<NULL>	8327	Comparative bioavailability study of three Benznidazole formulations after ingestion of a specific meal - STPh 02/22	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2022-10-01	Scentryphar Pesquisa Clínica Ltda	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-6zfzs4j	<NULL>	Healthy volunteers; both genders; aged 18 to 50 years; body mass index between 19 and 30 kg/m²; willing to use condoms during the study and up to 7 days after the last dose of the medication; able to understand the nature and purpose of the study, including risks and adverse events	Pregnancy; breastfeeding; smoking; history of alcohol or drug abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-10bbr596	Use of Platelet-Rich Plasma and Low-Level Laser to improve Skin Lesions caused by Psoriasis	Recruiting	Intervention	2025-09-30	<NULL>	<NULL>	8328	Effects of the combination of Platelet-Rich Plasma and Low-Level Laser Therapy on Psoriasis-Related Skin Lesions: a case study	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-21	Universidade Federal de São Paulo	Departamento de Biociências -Baixada Santista - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10bbr596	<NULL>	Confirmed diagnosis of psoriasis. A female patient aged between 40 and 45 years. Presence of lesions localized on the lower limbs. Overall satisfactory health status, without severe comorbidities that interfere with the evaluation and treatment of psoriasis. Confirmed diagnosis of psoriasis with lesion extent greater than 1 and severity index greater than 1, defined by the Psoriasis Area and Severity Index (PASI) score obtained during the initial evaluation conducted by the study researchers. At least four weeks without the use of topical corticosteroids or other local therapies in the treatment area	Presence of other dermatological conditions. Immunological or severe comorbidities. History of severe allergic reactions to any component of the treatments used in the study. Use of medications that interfere with the study. Inability to attend regular follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-586t2rv	Study to observe the efficacy and safety of plasmapheresis treatment in patients with Focal and Segmental Glomerulosclerosis (FSGS) after kidney transplantation	Recruiting	Observational	2025-09-30	<NULL>	<NULL>	8329	Observational, prospective study to evaluate the efficacy and safety of the therapeutic regimen and plasmapheresis in patients with Focal Segmental Glomerulosclerosis (GESF) after kidney transplantation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-09-03	Hospital do Rim -  Escola Paulista de Medicina - Universidade Federal de São Paulo	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-586t2rv	<NULL>	Signed informed consent form. Male or female participants aged between 5 and 75 years old at the time of signing the informed consent form or informed assent form. Be able to comply with the study protocol, according to the investigator&apos;s assessment. Be a kidney transplant patient. Have a diagnosis of focal segmental glomerulosclerosis (FSGS) according to the following criteria, persistently elevated proteinuria (UPCR greater than or equal to 3 in 3 daily serial measurements without showing a 50 percent reduction in proteinuria at that time). Have a kidney biopsy before or during screening. Diagnosis should be based on light microscopy, immunofluorescence and, if possible, electron microscopy. For fertile women, agreement to remain abstinent (abstain from heterosexual intercourse) or use adequate contraception during the treatment period and for 18 months after the final dose of rituximab, a woman is considered fertile if she is postmenarchal, has not reached postmenopausal status (greater than or equal to 12 continuous months of amenorrhea with no identified cause other than menopause) and is not permanently infertile due to surgery (i.e. removal of the ovaries, fallopian tubes or uterus) or another cause as determined by the investigator (e.g. agenesis of Muller&apos;s ducts), the definition of fertile status may be adapted to standardize with local guidelines or norms. the following are examples of appropriate contraceptive methods: bilateral tubal ligation; male sterilization; hormonal contraceptives; hormone-releasing intrauterine devices; copper intrauterine devices; male or female condom with or without spermicide and hood, diaphragm or sponge with spermicide, the reliability of sexual abstinence should be assessed in relation to the duration of the clinical study and the patient&apos;s preferred and daily lifestyle, periodic abstinence (e.g. tab methods, ovulation, methods) and coitus interruptus are not adequate contraceptive methods, if required by local guidelines or standards, locally recognized adequate contraceptive methods and information on the reliability of abstinence will be described in the local informed consent form	Patients with a secondary cause of Focal Segmental Glomerulosclerosis (FSGS) after kidney transplantation (e.g., rejection, infections such as hepatitis B, Systemic Lupus Erythematosus (SLE), medications, malignancies). Pregnant or breastfeeding women, or women intending to become pregnant during the study or within 18 months after the final dose of rituximab. Receipt of a live vaccine within 28 days before or during screening. Thrombocytopenia, anemia, and/or coagulopathy with a high risk of clinically significant bleeding. Significant or uncontrolled clinical disease that, in the investigator&apos;s opinion, would prevent the patient from participating. Known infection with Human Immunodeficiency Virus (HIV). Known active infection of any type, excluding fungal infection of the nail beds. Any major episode of infection requiring hospitalization or treatment with IV anti-infective treatments during the 2 months before or during screening or with oral anti-infective treatments during the 2 weeks before or during screening. History of recurrent or chronic severe infection. History of progressive multifocal leukoencephalopathy (PML). History of cancer, including solid tumors, hematologic malignancies, and carcinoma in situ, except for treated or excised and resolved non-melanoma skin carcinomas. Active alcohol or drug abuse or history of alcohol or drug abuse in the 11 months prior to screening. Intolerance or contraindication to the therapies under study, including: Evidence of intolerance or toxicity associated with rituximab prior to screening. History of severe or anaphylactic allergic reactions to monoclonal antibodies or known hypersensitivity to any component of the rituximab infusion. Intolerance or contraindication to oral or IV corticosteroids and premedications. Absence of peripheral venous access. Laboratory parameters  Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) &gt; 2.5 x the upper limit of normal (ULN). Amylase or lipase &gt; 2 x ULN. Neutrophils &lt; 1.5 x 103 /uL. CD19+ B cells &lt; 5/uL. Hepatitis B surface antigen (HbsAg) positive on screening. Patients who are HBsAg negative and positive for hepatitis B core antibody without detectable hepatitis B virus (HBV) DNA will be allowed in the study, but will require regular monitoring of hepatitis B virus (HBV) DNA. Positive antibody against hepatitis C virus (HCV) in screening. Patients with a positive test result for hepatitis C antibody without detectable hepatitis C virus (HCV) RNA for at least 12 months after completion of antiviral therapy are eligible, but will require regular monitoring of hepatitis C virus (HCV) RNA. Hemoglobin &lt; 9 g/dL. Platelet count &lt; 75,000/uL. Positive serum human chorionic gonadotropin measured at screening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-673psmx	Propolis Spray for the treatment of Oral Mucositis	Recruiting	Intervention	2025-09-30	<NULL>	<NULL>	8330	Effecacy of Propolis Spray (Apis mellifera L) for the prevention and treatment of Oral Mucositis induced by Radiotherapy in patients with Head and Neck Cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-12	Sociedade Pernambucana de Combate ao Câncer	Sociedade Pernambucana de Combate ao Câncer	https://ensaiosclinicos.gov.br/rg/RBR-673psmx	<NULL>	Patients with head and neck cancer; patients undergoing radiation therapy with or without associated chemotherapy; patients over 18 years of age, from both sexes	Patients with metastasis; latients undergoing radiotherapy as palliative care; patients with allergies to propolis or any substance contained in the spray formula; patients unable to complete the questionnaires or in a serious condition that prevents them from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-35hyxxv	Effectiveness of a remote-guided physical activity program	Data analysis completed	Intervention	2025-09-30	<NULL>	<NULL>	8331	Effectiveness of a remote-guided Physical Activity Program on the health of adolescents with Severe Obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-08	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-35hyxxv	<NULL>	Adolescents aged 12 to 17 years with obesity (BMI z-score ≥ 2 for sex and age, according to WHO standards)	Disabling orthopedic or neurological conditions; inability to engage in regular physical activity; diagnosed mental disorders limiting adherence; participation in other structured weight loss or exercise programs (except school Physical Education); or lack of access to an internet-connected device with a camera.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-10vnmdb7	Effect of Aerobic and Isometric Physical Exercise with handgrip on blood pressure in people with Medication-Resistant Hypertension	Recruiting	Intervention	2025-09-30	<NULL>	<NULL>	8332	Effect of Aerobic and Isometric Physical Exercise with Handgrip on Blood Pressure in Resistant Hypertensive Individuals: Evaluation of Autonomic and Hemodynamic Mechanisms	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-08	Instituto de Educação Superior da Paraíba - IESP	Instituto de Educação Superior da Paraíba - IESP	https://ensaiosclinicos.gov.br/rg/RBR-10vnmdb7	<NULL>	Volunteers both genders, with medication-resistant hypertension; older than 18 years; non-smoking; no history of ischemic or hemorrhagic stroke, coronary heart disease, chronic obstructive or restrictive pulmonary disease, and chronic atrial fibrillation; be able to participate in the research protocol; do not practice regular physical exercise; be available to undergo the experimental protocol	Volunteers who modify the initial medication pattern; practice another type of physical exercise program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-4b7xq9v	Safety and effects of using different Masks and Cannulas used to assist breathing in Premature Babies	Not yet recruiting	Intervention	2025-09-30	<NULL>	<NULL>	8333	Safety and effectiveness of different Interface models for Noninvasive Ventilation support for Preterm Newborns with gestational age greater than 28 weeks	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Fundação Hospitalar de Feira de Santana	Fundação Hospitalar de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-4b7xq9v	<NULL>	Preterm newborns, that is, those born before completing 37 weeks of gestational age; with a gestational age greater than 28 weeks; of both sexes; admitted to the neonatal intensive care unit; with mild to moderate respiratory distress identified by the Silverman Andersen bulletin; authorized by the guardian to participate in the research by signing the free and informed consent form	Patients with multiple congenital malformations; intolerant to non-invasive ventilation interfaces; patients whose legal guardians do not sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-5kq7w75	Effects of Physical Exercise on motor, behavioral and sensory aspects of children with Autism Spectrum Disorder	Recruitment completed	Intervention	2025-09-30	<NULL>	<NULL>	8334	Randomized clinical trial: effects of Physical Exercise on motor, behavioral and sensory aspects of children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5kq7w75	<NULL>	Ages 4 to 6; both sexes; present a report diagnosing the child with Autism Spectrum Disorder, based on the criteria of DSM-5, DSM-5-TR, ICD-10, or ICD-11 with support levels 1 and 2; participate in a maximum of 2 concurrent therapies; must demonstrate minimum comprehension and interaction skills to perform the proposed activities; signature of the child&apos;s informed consent form (TALE); authorization of parents/guardians by signing the informed consent form (TCLE)	With severe intellectual impairment; nonverbal; participating in an intensive motor intervention program; being assisted by an occupational therapist; physical inability to exercise at moderate intensities; children with more than 20% absences from the total number of sessions; refusal to sign the consent form to participate in the study; parents who refuse to sign the consent form to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-287z2nh	Inflammatory components of saliva and gingiva of teeth that will receive prosthetic crowns at different clinical stages and the influence of a treatment to control blood pressure on these components	Data analysis completed	Intervention	2025-09-29	<NULL>	<NULL>	8320	Inflammatory components in saliva and gingival crevicular fluid of teeth receiving metal-ceramic crowns at different clinical stages and the influence of the renin-angiotensin system on treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-04-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-287z2nh	<NULL>	Patients must not present with any form of periodontitis (e.g., aggressive, chronic, necrotizing); They must be between 30 and 60 years of age; without gender distinction; without race distinction; Participants must present with premolars indicated for restoration with metal-ceramic crowns, regardless of pulpal vitality; The teeth adjacent to those receiving crowns must exhibit the following characteristics: probing depth less than or equal to 3 mm, absence of bleeding on probing and attachment loss, and the presence of contralateral natural premolars; For inclusion in the experimental groups (under treatment with Angiotensin II Type 1 Receptor Blockers or Angiotensin Converting Enzime inhibitors), patients must have been undergoing such treatment for at least six months;	Presence of periodontitis; diagnosis of diabetes mellitus; smoking; pregnancy; lactation; iodine allergy; current orthodontic treatment; use of immunosuppressants; use of anticonvulsants; use of antibiotics; use of anti-inflammatory drugs; use of other classes of antihypertensive medications such as calcium channel blockers and beta-blockers;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-2y72dnm	The effect of Chlorhexidine mouth rinses on blood pressure in healthy people	Recruitment completed	Intervention	2025-09-29	<NULL>	<NULL>	8321	Evaluation of the effect of Chlorhexidine mouthwash use on blood pressure in healthy individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Centro Universitário do Planalto Central - Uniceplac	Centro Universitário do Planalto Central - Uniceplac	https://ensaiosclinicos.gov.br/rg/RBR-2y72dnm	<NULL>	Age over 18 years; good health status	Use of antimicrobials and/or mouthwash in the past three months; Smoking; Alcoholism; Diabetes; Autoimmune diseases; Gingivitis; Periodontitis; Oral mucosal lesions; Borderline blood pressure values	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-57gn649	Effect of Brain Light Therapy on Gait and Balance in People with Parkinson’s Disease	Recruiting	Intervention	2025-09-29	<NULL>	<NULL>	8322	Effect of transcranial photobiomodulation on gait and postural control in people with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Pedro Paulo Gutierrez	Universidade Estadual Paulista (UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-57gn649	<NULL>	Participants with Parkinson’s disease will be recruited from the Physical Activity Program for Patients with Parkinson’s Disease and the local community, based on the following inclusion criteria: (i) a diagnosis of idiopathic Parkinson’s disease made by a neurologist, according to the London Brain Bank criteria, and (ii) classification between stages 1 and 3 on the Hoehn and Yahr scale	Exclusion criteria include: (i) a history of orthopedic and/or visual impairments that prevent compliance with the experimental protocol; (ii) uncontrolled diseases that may affect peripheral sensory functions (e.g., diabetes); (iii) conditions that pose a risk for Transcranial Photobiomodulation, such as structural brain disease, epilepsy, or the use of potentially photosensitizing medications (e.g., imipramine, phenothiazines, lithium, chloroquine, hydrochlorothiazide, tetracycline); (iv) clinical signs of dementia, defined as a Mini-Mental State Examination score below 20; and (v) failure to complete the 18 required modulation/evaluation sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-8cq89mp	Effectiveness and safety of at-home tooth Whitening: a clinical study	Not yet recruiting	Intervention	2025-09-29	<NULL>	<NULL>	8323	Efficacy and safety of DSP Home Tooth Whitening: A prospective, single-Blind, randomized study	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-09-30	Universidade Estadual de Ponta Grossa	Programa de Pós Graduação em Odontologia da Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8cq89mp	<NULL>	Patients of both sexes; aged 18 years or older; in good general and oral health; absence of carious lesions, restorations, and endodontic treatment in at least the six maxillary anterior teeth; right and left maxillary canines with shade A2 or darker, assessed by comparison with a value-oriented shade guide	Patients with dental prostheses; orthodontic appliances; pregnant or breastfeeding women; smokers; participants with a history of tooth whitening procedures; individuals with bruxism; gingival recession; dentin exposure; visible cracks in the teeth; history of dentin hypersensitivity; users of anti-inflammatory medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-6jvvp9t	Evaluation of the effect of Teriparatide associated with increased bone quantity on preservation of the root cavity after tooth extraction: a randomized split-mouth clinical study	Recruitment completed	Intervention	2025-09-29	<NULL>	<NULL>	8324	Evaluation of the effect of Teriparatide associated with xenogenous graft on post-extraction alveolar preservation: a randomized split-mouth clinical study	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2024-09-01	Instituto Latino Americano de Pesquisa e Ensino Odontológico	Faculdade ILAPEO	https://ensaiosclinicos.gov.br/rg/RBR-6jvvp9t	<NULL>	Patients of both genders between; 18 and 70 years old; healthy; with an indication for the extraction of two contralateral posterior teeth in the mandible or maxilla; having teeth adjacent to the extraction site	Presence of Acute Periapical/Periodontal Infection (Abscesses); presence of Periodontal Sisease; use of medications such as Chemotherapy, Anticoagulants, Corticosteroids, Anti-resorptive drugs (Bisphosphonates or RANKL modulators) and Immunosuppressive drugs; systemic use of Teriparatide; decompensated chronic diseases (e.g. Hypertension, diabetes, Rheumatological, Renal and Hepatic diseases); history of Anxiety, Mood, Eating and/or Psychotic Disorders that could compromise their participation and collaboration in the study; metabolic bone diseases (Osteomalacia, Hypocalcemia, Hypercalcemia, Osteoporosis); motor dysfunction that makes oral hygiene impossible or difficult; smokers; pregnant women; radiotherapy in the last 5 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-5p2xqqr	Diabetic neuropathy and recurrent laryngeal nerve involvement in patients undergoing thyroid surgery: evaluation of 50 cases	Data analysis completed	Observational	2025-09-29	<NULL>	<NULL>	8325	Comparative study between the values of recurrent laryngeal nerve latency in diabetic and non-diabetic patients undergoing thyroidectomy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-5p2xqqr	<NULL>	Volunteers of both sexes; age between 18 and 80 years; with or without a diagnosis of Diabetes; undergoing Elective Thyroidectomy Surgeries; laboratory tests collected within 90 days of the date of Surgery; signing of the informed consent form	Volunteers with comorbidities that could interfere with glycated hemoglobin values, such as Sickle Cell Anemia or Iron Deficiency; Blood Transfusion in the last year; Dialysis in the 90 days prior to the Surgical Procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-10rc68s9	Validation of an exercise protocol with a specific instrument for cervical muscle strength gain in individuals with neck pain	Recruitment completed	Intervention	2025-09-26	<NULL>	<NULL>	8315	Validation of an exercise protocol with a specific instrument for acquiring cervical muscle strength in individuals with neck pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-03	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-10rc68s9	<NULL>	Insidious pain for more than 3 months; average pain intensity of 1 to 5 on the numerical scale; score greater than or equal to 10 and less than 60% on the NDI (Neck Disability Index); people aged between 18 and 65 years; women or men (no gender restriction)	Previous history of neck trauma or surgery; neck pain lasting less than 3 months; oncological and infectious pathologies of the spine; vestibular pathology; complaints of dizziness and tinnitus; individuals undergoing treatment for shoulder dysfunction; occurrence of any musculoskeletal trauma during the study period; withdrawal of the Informed Consent Form and worsening of neck pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-8h45h43	Altitude-simulated Training applied to team sport athletes	Data analysis completed	Intervention	2025-09-26	<NULL>	<NULL>	8316	Acute and chronic responses to Inter-effort Recovery Hypoxia associated with Small-sided Games and Sprint Interval Training in team sport athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Escola de Educação Física e Esporte de Ribeirão Preto, Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8h45h43	<NULL>	Male handball athletes aged between 18 and 35 years	Failure to complete two or more sessions of the chronic protocol; failure to complete one session of the acute protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-9wyn4g7	Smart Pre-Surgery Prep: How a Carbohydrate Drink Can Improve Your Body’s Recovery	Not yet recruiting	Intervention	2025-09-26	<NULL>	<NULL>	8317	Effects of Carbohydrate Solutions (Preloading) on Physiological Outcomes and Endocrine-Metabolic Response to Perioperative Trauma in Patients Undergoing Elective Craniotom	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal do Piauí	Hospital Getúlio Vargas	https://ensaiosclinicos.gov.br/rg/RBR-9wyn4g7	<NULL>	Individuals aged between 18 and 90 years; undergoing elective craniotomy for a single intracranial lesion; who signed the informed consent form	Exclusion criteria: patients with cranial trauma; emergency surgery (making it impossible to perform preoperative preparation with the solution); altered level of consciousness prior to surgery; lack of cooperation; pregnancy; presence of factors that delay gastric emptying or comorbidities that could affect postoperative recovery, such as: paralysis; spinal deformity; autoimmune diseases; coronary artery disease; severe infection; diabetes; or other dysfunctions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-9c374yd	Tranexamic acid: less bleeding and fewer complications in laparoscopic prostate surgery	Terminated	Intervention	2025-09-26	<NULL>	<NULL>	8318	Efficacy of tranexamic acid in reducing bleeding and complications in laparoscopic Prostatovesiculctomy	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2021-05-10	Fundação Cristiano Varella	Fundação Cristiano Varella	https://ensaiosclinicos.gov.br/rg/RBR-9c374yd	<NULL>	Male patients; with a confirmed diagnosis of localized prostate cancer; aged 50 years or older; who are indicated for radical prostate-vesiculectomy by videolaparoscopy; with or without pelvic and/or retroperitoneal lymphadenectomy; Patients must be capable of providing informed consent and signing the Informed Consent Form (ICF); Additionally, patients must have an Eastern Cooperative Oncology Group (ECOG) performance status score between 0 and 2	Patients with a known history of allergic reactions to tranexamic acid or any other component of the formulation; patients with severe cardiovascular diseases, including recent myocardial infarction, congestive heart failure, or active venous thromboembolism; patients with severe renal insufficiency or a history of coagulopathies; use of anticoagulants or antiplatelet agents within 7 days prior to surgery; or any medical condition that, in the opinion of the investigator, may compromise patient safety or the integrity of the study data	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-2x5w7rf	Horizontal Bone Augmentation - comparison of Dome Technique with Guided Bone Regeneration: randomized clinical study	Not yet recruiting	Intervention	2025-09-25	<NULL>	<NULL>	8310	Horizontal Bone Augmentation of the Alveolar Ridge using the Polydioxanone Dome Technique versus Guided Bone Regeneration: a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-10-01	Departamento de Odontologia da Universidade Federal de Santa Catarina	Departamento de Odontologia da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2x5w7rf	<NULL>	Partially edentulous adult patients; minimum age of 18 years; with horizontal alveolar bone deficiency (less than 4 mm in thickness), confirmed by Cone-Beam Computed Tomography (CBCT); with adjacent teeth to the bone defect areas, in an edentulous space of no more than two missing teeth; adequate oral hygiene (plaque index of 25% or less); no history of bone augmentation procedures in the edentulous area; both sexes	Uncontrolled systemic and local conditions, such as uncontrolled diabetes; pregnant women; smokers; extraction sites with less than 3 months of healing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-6fy2t8m	Conservative treatment for facial pain  of muscular origin  in patients with facial  and neck pain	Recruitment completed	Intervention	2025-09-25	<NULL>	<NULL>	8311	Conservative treatment of muscle Temporomandibular Dysfunction in patients with Temporomandibular Dysfunction and cervical pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6fy2t8m	<NULL>	Patients between 18 and 65 years of age; men and women; classification of muscular Temporomandibular Disorders according to the diagnostic criteria in research for Temporomandibular Disorders (myofascial pain and myofascial pain with limitation of opening); with pain for more than 3 months; complaint of pain in the face and mechanical-postural Cervicalgia grade I or II; according to Neck Pain Task Force for more than 3 months on the Numerical Scale of Pain between 3- 8 cm; agreement and signing of the Free and Informed Consent Form	Patients with neuromuscular diseases; autoimmune or rheumatological diseases; cervical pain that is not of postural mechanical origin; cervicogenic neck pain; cervical trauma related to pain; use of orthodontic appliances; have changed or started medication in the last 3 months; practice of physical activity started or changed in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-2mtwjnz	Effects of Dietary Polyphenol Intake and Physical Activity on Body Fat, Metabolic and Inflammatory Markers in Breast Cancer Survivors – PROjeto POlifenóis no CAncer de Mama (PROPOCAM)	Recruiting	Intervention	2025-09-25	<NULL>	<NULL>	8313	Effects of Dietary Polyphenol Intake and Physical Activity on Body Fat, Metabolic and Inflammatory Markers in Breast Cancer Survivors: a Randomized Clinical Trial – PROjeto POlifenóis no CAncer de Mama (PROPOCAM)	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-20	Universidade Federal de Santa Catarina - UFSC	Prefeitura Municipal de Imbituba	https://ensaiosclinicos.gov.br/rg/RBR-2mtwjnz	<NULL>	Sample inclusion will follow the criteria below: women with a diagnosis of primary breast cancer confirmed by histopathological evidence of malignancy; staging classified as 0 to IIIb at the time of diagnosis; completion of chemo- and/or radiotherapy treatment at least 6 months prior to the start of the study and less than 5 years; age between 30 and 75 years; sedentary women (&lt;60 minutes of physical activity per week); BMI &gt;25 kg/m²; medical clearance to engage in physical activity issued by an oncologist or cardiologist; no regular alcohol consumption (no more than one drink/week — i.e., one can of beer, 150 mL of wine, or 45 mL of distilled beverage); no use of dietary supplements within the previous 3 months and no current clinical conditions such as infections or visible/known inflammatory processes; absence of cardiovascular, endocrine, gastrointestinal, renal, or hepatic diseases.	The non-inclusion criteria will comprise the following factors: history of other types of cancer; presence of metastasis or recurrence; pregnancy or lactation; BMI &lt;25 kg/m²; current smoking.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-5hd8ckd	Cannabis-derived product for analgesia in third molar surgery: A randomized, double-blind clinical trial	Recruiting	Intervention	2025-09-25	<NULL>	<NULL>	8314	Cannabidiol for preemptive analgesia in third molar extraction: A randomized, double-blind clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2025-08-13	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	https://ensaiosclinicos.gov.br/rg/RBR-5hd8ckd	<NULL>	Healthy participants without systemic involvement; of both genders; aged between 18 and 40 years; who required extraction of bilaterally impacted lower third molars diagnosed by orthopantomograms; Teeth with similar bilateral bone impactions, assessed by panoramic radiography, presenting the same dental impaction classification (IIB) according to Pell and Gregory (1933) and Winter (1926)	Research participants who used analgesics or anti-inflammatories in the 48 hours prior to tooth extractions; research participants with sensory-sensory alterations; research participants who are pregnant or lactating, or who present a positive rapid pregnancy test (to be performed on the day of the procedure); research participants with any history of hypersensitivity reactions to any of the medications that will be used in the study: mepivacaine, amoxicillin, ibuprofen, dipyrone, chlorhexidine, and cannabidiol; research participants who test positive at the time of surgery for previous use of Cannabis sativa (Test to be performed on the day of the procedure); research participants who present an infection or postoperative alveolith; research participants who do not follow postoperative recommendations; research participants who do not attend follow-up appointments; when the surgical time exceeds 60 minutes; when technical failure in anesthesia occurs or when the use of more than 3 anesthetic tubes is necessary; research participants who use any medication with analgesic and/or anti-inflammatory action in the postoperative period, in addition to those prescribed in the study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-5ky63kv	Assessment of oral acceptability after use of a mouth spray and participants impressions after use, following the instructions for use	Recruitment completed	Intervention	2025-09-24	<NULL>	<NULL>	8309	Assessment of oral cavity acceptability after use of a mouth spray (class I health product) and assessment of efficacy perceived by the research participant, under recommended conditions of use (E007843A)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	ALS Beauty &amp; Personal Care Ltda	ALS Beauty &amp; Personal Care Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5ky63kv	<NULL>	Healthy research participants; agreement to adhere to the study procedures and requirements and to attend the institute on the days and times determined for the evaluations; ability to consent to their participation in the study; age from 18 to 70 years; any sex; vaccinated against covid 19; who self declare as having a predisposition to sensitive oral mucosa and with the occurrence of mouth ulcers or oral wounds caused by factors such as stress, acidic foods, burns, ingestion of hot foods, use of orthodontic appliances, stomatitis, use of medications or herpes; who self declare as having sensations of dry mouth	Participants who smoke; are pregnant or breastfeeding; have changes outside the normal range assessed by the dentist in the oral cavity that may compromise the results of the study or that may put the participant&apos;s health at risk; are undergoing any medical treatment that, in the opinion of the investigator, may compromise the results of the study or put the participant&apos;s health at risk; have skin conditions in the area where the product is applied; have removable partial or total dentures, provided that more than 50% of the teeth are missing; have type 1 diabetes mellitus; are insulin-dependent diabetes; have complications resulting from diabetes, such as retinopathies, nephropathy, neuropathy; have dermatoses related to diabetes, such as plantar ulcers, lipoid necrobiosis, granuloma annulare, and opportunistic infections; have a history of episodes of hypoglycemia, diabetic ketoacidosis, and/or hyperosmolar coma; are undergoing immunosuppression; are currently using topical or systemic corticosteroids, immunosuppressants, and antihistamines; have a history of reactions to the category of the product being tested; other diseases or medications that may directly interfere with the study or put the health of the research participant at risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-2wh9tm5	The nurse visit for hospital discharge safety	Recruiting	Intervention	2025-09-23	<NULL>	<NULL>	8304	The nurse visit as an instrument for hospital discharge safety: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Sociedade Beneficente de Senhoras Hospital Sírio-Libanês	Sociedade Beneficente de Senhoras Hospital Sírio-Libanês	https://ensaiosclinicos.gov.br/rg/RBR-2wh9tm5	<NULL>	Patients discharged from the hospital within the study period, regardless of gender; who are at least 18 years old will be included in the study	Patients transferred to other hospital units or healthcare institutions before discharge; patients who do not respond to the Hospital Consumer Assessment of Healthcare Providers and Systems instrument after hospital discharge will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-767cyvb	Effects of Florals on anxiety, quality of sleep and quality of life of medicine students	Data analysis completed	Intervention	2025-09-23	<NULL>	<NULL>	8305	Evaluation of the effects of Floral Essences on anxiety, quality of sleep and quality of life of medicine students from a university in south Brazil: a clinical trial randomized and controlled	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-08	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-767cyvb	<NULL>	Healthy medical students; from UNISUL; who do not have any diagnosed disease and/or are not undergoing treatment; both genders	Students with immunosuppressive diseases; oncological diseases; infectious diseases; or in a febrile state; epilepsy; diagnosed with depression; pregnant and/or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-43q97jm	The role of inflammatory substances and cell stress in Inflammatory Bowel Disease	Data analysis completed	Intervention	2025-09-23	<NULL>	<NULL>	8306	Oxidative stress and cytokine activity in Inflammatory Bowel Disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-03-13	Fundação de Amparo à Pesquisa do Estado do Piauí - FAPEPI	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-43q97jm	<NULL>	Both sexes. Aged between 20 and 59. Clinical diagnosis of ulcerative colitis. Non-smokers. No comorbidities such as diabetes, hypertension, kidney failure, cardiovascular disease, rheumatic diseases or other diseases with inflammatory processes. Not using a vitamin-mineral supplement that interferes with zinc metabolism. Not be currently using monoclonal antibody therapy. Participants linked to the Association of Crohn&apos;s Disease Patients of the North and Northeast of Brazil (ACROHNN). Follow-up at the University Hospital of the Federal University of Piauí (HU-UFPI)	Start of monoclonal antibody therapy during the study. Change of city or state. Lack of telephone contact. Inability to continue using the supplement. Absence from biological material collection. Age group outside the 20-59 age range. No relationship with ACROHNN. No follow-up by HU-UFPI. Diagnosis of an intestinal disease other than Ulcerative Retocolitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-7rk9hn7	Treatment of knee Osteoarthritis with Bone Marrow Aspirate Concentrate	Recruiting	Intervention	2025-09-23	<NULL>	<NULL>	8307	Treatment of Knee Osteoarthritis with Bone Marrow Aspirate Concentrate: Prospective Randomized Trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-06-01	Faculdade de Medicina da Universidade Federal Fluminense	Hospital Universitário Antonio Pedro/Empresa Brasileira de Serviços Hospitalares	https://ensaiosclinicos.gov.br/rg/RBR-7rk9hn7	<NULL>	Age between 50 and 70 years old; both sexes; diagnosis of Bilateral Osteoarthritis of the knee, according to the criteria of the American College of Rheumatology; radiographs with a Kellgren-Lawrence classification higher than III in both knees; present full range of motion (0 to 120°)	History of previous trauma, infection or surgery in the same knee in the last 2 years;limb malalignment (varus&gt;10º and valgus &gt; 15º);corticosteroid infiltration in the same knee in the last 3 months;hyaluronic acid ; unfiltration in the same knee in the last 12 months;inflammatory, autoimmune or neoplasic disease;body mass index&gt; 35 kg/m2; use of immunosuppressants or anticoagulants; active neoplasia; hematologic disorders; history of transmissible disease accute or chronic; living outside Rio de Janeiro metropolitan area; participants without full autonomy, blind, deaf or illiterate; patients unable for positioning; patients using statins	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-103jtq75	Use of Cannabis extract in the treatment of Alzheimer&apos;s Disease symptoms: a study with elderly patients	Recruiting	Intervention	2025-09-23	<NULL>	<NULL>	8308	Balanced Cannabis extract and its potential therapeutic application in Alzheimer&apos;s Disease: a randomized clinical trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2025-07-23	Faculdade de Medicina de Jundiaí	Apoio a Pesquisa e Pacientes de Cannabis Medicinal - APEPI	https://ensaiosclinicos.gov.br/rg/RBR-103jtq75	<NULL>	Be a patient at the Geriatric Outpatient Clinic of the Jundiaí Medical School; have a confirmed clinical diagnosis of moderate Alzheimer&apos;s disease; be aged 60 or over; be able to administer Cannabis sativa extract orally; both males and females will be accepted; the potential inability of participants to give their consent independently will be respected, with free and informed consent required through a legal guardian, as determined by National Health Council (CNS) Resolution No. 466 of 2012	Have a history of significant adverse reactions to cannabidiol (CBD) and tetrahydrocannabinol (THC); have severe cardiovascular disease; have significant liver or kidney disorders; have uncontrolled endocrine disorders; have severe respiratory disorders; have active autoimmune conditions; have other severe neurological or psychiatric disorders; use medications that may interfere with the results, such as antidepressants, antipsychotics, or benzodiazepines; have previously used Cannabis sativa products containing cannabidiol (CBD) and tetrahydrocannabinol (THC) in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-37fpj5d	Efficacy of Cerebellar Neuromodulation on balance in active community-dwelling elderly people	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8294	Efficacy of Cerebellar Repetitive Transcranial Magnetic Stimulation on postural balance in active community-dwelling elderly people	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-15	Centro de Ciências da Saúde da Universidade Federal do Espirito Santo	Programa de Pós-Graduação em Ciências Fisiológicas da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-37fpj5d	<NULL>	Community-dwelling elderly; both genders; aged over 60; independent mobility; preserved bipedal stance; preserved walking ability	Neuropsychiatric crises; history of seizures; use of a cardiac pacemaker; use of ocular prosthesis; presence of a metal clip in the head; presentation of unstable vital signs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9yfmhcx	Comparative study before and after speech therapy in patients with  Apnea	Data analysis completed	Intervention	2025-09-22	<NULL>	<NULL>	8295	Comparative pre- and post-study of an orofacial myofunctional therapy program in patients with Obstructive Sleep Apnea	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-26	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9yfmhcx	<NULL>	Adult patients; men and women; aged between 19 and 65 years; literate; diagnosed with obstructive sleep apnea confirmed by polysomnography regardless of the degree of apnea; with a body mass index less than 35 kg/m²; who participated in the 12 session therapeutic program lasting an average of 3 months; who underwent polysomnography again at the end of the program and signed the informed consent form	Male and female patients with other sleep disorders; previous apnea treatment; use of continuous positive airway pressure; intraoral appliances and surgery; use of alcohol; stimulants or sedatives; major craniofacial alterations; failure to comply with the therapeutic program; no polysomnography examination before or after the therapeutic program; or not accept the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-8v7rsdp	Effects of Whole-body LED on blood glucose levels in men with Type 2 Diabetes	Recruitment completed	Intervention	2025-09-22	<NULL>	<NULL>	8296	Dose-response and time-response of Whole-Body Photobiomodulation on blood glucose in men with Type II Diabetes Mellitus: a randomized, double-blind, sham-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-20	Departamento de Fisioterapia	Departamento de Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-8v7rsdp	<NULL>	Study participants must be male; between 40 and 70 years old; with a low level of physical activity (according to the International Physical Activity Questionnaire (IPAQ) classification); BMI up to 34.9 kg/m² (grade I obesity); body fat percentage up to 45 mm after the sum of skinfolds; medical diagnosis of DM2 for at least 5 years; regular use of oral hypoglycemic medication for at least 6 months	Participants with fasting capillary blood glucose &gt;200 mg/dL; alcoholics; drug addicts; insulin-dependent individuals; heart patients using pacemakers; those with any cognitive deficit; neurological or pulmonary disease; and those diagnosed with any type of cancer undergoing treatment will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:12
RBR-6vghpr5	Influence of Guided Surgical Approach on Immediate Dental Implants Planned by Cone Beam Computed Tomography	Recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8297	Influence of guided surgical approach in immediate dental implants planned by Cone-Beam Computed Tomography: A randomized clinical trial on treatment plan efficacy and patient outcomes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6vghpr5	<NULL>	Over 18 years of age. Both sexes. Presence of a tooth indicated for extraction. Indication for oral rehabilitation through immediate dental implant placement	Smokers. Patients with systemic diseases or neoplastic conditions involving bone tissue. History of radiation therapy in the head and neck region. Classified as ASA III to V according to the American Society of Anesthesiologists. Use of functional orthopedic appliances or fixed or removable orthodontic appliances. Severely compromised dentition in a generalized manner. Presence of active periodontal disease or local infection. Severe bruxism. Less than 2 mm of bone tissue beyond the apex of the tooth under evaluation. Imaging examinations with compromised technical quality. Limited intermaxillary space or restricted mouth opening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-2mk8398	Ozone Therapy for the management of Oral Mucositis associated with cancer treatments	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8298	Evaluation of Ozone Therapy in the control of Oral Mucositis induced by antineoplastic therapies: randomized clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Estadual do Oeste do Paraná	Hospital do Câncer Uopeccan	https://ensaiosclinicos.gov.br/rg/RBR-2mk8398	<NULL>	Patients aged 18 years or older. Patients of both sexes. Patients with confirmed diagnosis of malignant neoplasm in the oral cavity. Patients undergoing chemotherapy or radiotherapy at the Uopeccan Cancer Hospital. Patients presenting with oral mucositis grade I to III according to the World Health Organization (WHO) classification. Patients using standard medications for mucositis management according to the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) guidelines. Patients who provide informed consent	Patients with malignant neoplasm in the hypopharynx, salivary glands, or lips. Patients with mucositis extending to the oropharynx or esophagus. Patients undergoing concomitant alternative therapies, such as biological agents or cryotherapy. Patients with severe comorbidities. Patients using medications not included in the guidelines of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Patients undergoing antineoplastic treatment not exclusively at the Uopeccan Cancer Hospital	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-633mkf7	Best Pain Block with Ultrasound in kids: comparing techniques for Abdominal Surgeries	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8299	Comparative study between Ultrasound-Guided Quadratus Lumborum Blocks, TAP Blocks, and Sacral Epidural Anesthesia in pediatric patients undergoign Abdominal Wall Surgery: a randomized double-blind study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-10-01	Hospital São Domingos	Hospital Infantil Dr. Juvêncio Matos	https://ensaiosclinicos.gov.br/rg/RBR-633mkf7	<NULL>	Pediatric patients undergoing elective unilateral or bilateral abdominal wall surgery; both genders; age between 1 and 8 years; American Society of Anesthesiologists (ASA) physical status classification I or II	Pediatric patients presenting American Society of Anesthesiologists (ASA) physical status classification III or IV; skin redness or infection at the needle injection site; diagnosis of coagulopathy; liver disease; motor developmental delay; known allergy to local anesthetics; parental refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-7jx4hhb	Remote Management and control of blood pressure, glycemia and lipids	Recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8300	Trial on the remote management and control of blood pressure, glycemia and lipids in a diverse community-based population: a decentralized, prospective, randomized and open-label study - tamis trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Instituto de Ensino e Investigações Avançadas em Saúde	Fundação de Ensino e Pesquisa em Ciências da Saúde da Secretaria do Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-7jx4hhb	<NULL>	Patients of both sexes; aged 18 years or older; patients followed by a physician within the Brazilian Primary Healthcare Network with at least one medical visit in the past three years; patients with diabetes and glycated hemoglobin (HbA1c) ≥7.0%, and with blood pressure and/or LDL-C above guideline-recommended targets	Patients deemed unsuitable for the program at the physician’s discretion; presence of any active underlying malignancy; participation in another clinical trial	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-5g6rk3h	Evaluation of Pregabalin as preemptive analgesia in postoperative pain in orthopedic foot and ankle surgery: randomized clinical trial	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8301	Use of Pregabalin as preemptive analgesia in orthopedic foot and ankle surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-09-30	Centro Universitário CESMAC	Centro Universitário CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-5g6rk3h	<NULL>	Patients with surgical indications; originating from elective and emergency orthopedic clinics at Santa Casa de Misericórdia de Maceió; over 18 years of age; of both sexes	Patients with neuropathy of any etiology; history of abusive use or addiction to analgesics and opioids; history of allergy or intolerance to the use of Pregabalin; history of chronic use of Pregabalin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-5n7cg2n	The effect of the Vivifrail exercise program on improving functional Capacity in elderly people living in a geriatric home	Data analysis completed	Intervention	2025-09-22	<NULL>	<NULL>	8302	Efficacy of the Vivifrail program in improving Functionality in institucionalized elderly people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5n7cg2n	<NULL>	Elderly people of both sexes; aged 60 or over; be available to participate in functional tests; capable of understanding and carrying out the proposed activities	Elderly individuals who have cognitive deficits; musculoskeletal or joint injuries that prevent them from participating; who have decompensated heart; respiratory or metabolic disease; or any health condition that could significantly compromise the elderly individual&apos;s performance in the assessment tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-426p272	How to prevent Tooth Decay and Mouth Sores during Cancer treatment: the role of public universities in health and education	Not yet recruiting	Intervention	2025-09-22	<NULL>	<NULL>	8303	Prevention of Radiation Caries and Oral Mucositis in Cancer Patients: the transformative role of public universities in promoting health and education	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-31	Faculdade de Odontologia de Araraquara da Universidade Estadual Paulista (UNESP)	Santa Casa de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-426p272	<NULL>	Adults (aged 18 years or older); diagnosis of cancer in the head and neck region; indication for radiotherapy in this region, scheduled to begin within 20 days after recruitment, with or without concomitant chemotherapy; ability to understand and communicate in order to respond to questionnaires and adhere to the protocol; signed informed consent form (ICF).	History of previous radiotherapy in the head and neck region; allergy to any of the components of the products to be provided; participants with severe systemic complications, decompensated and unfit to receive the preventive protocols during treatment (e.g., degenerative neurological diseases, terminal conditions); completely edentulous participants; pregnant or breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-9qzjbkj	Evaluation of the Safety and Efficacy of Synthetic Bone Grafts	Recruitment completed	Observational	2025-09-22	<NULL>	<NULL>	8448	Clinical Efficacy and Satety of Nanosynt Synthetic Bone Grafting: a retrospective study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-06-28	Universidade do Extremo Sul Catarinense	FGM Dental Group	https://ensaiosclinicos.gov.br/rg/RBR-9qzjbkj	<NULL>	Patients over 18 years of age; both sexes; who underwent bone grafting with Nanosynt® (FGM Dental Group) between 2023 and 2025; who have complete records in clinical records, including anamnesis data, medical records and pre- and post-operative radiographic examinations	Patients with uncontrolled systemic comorbidities that may interfere with bone regeneration, such as diabetes mellitus and osteoporosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-57g75kp	Psychotherapy as life style	Terminated	Intervention	2025-09-19	<NULL>	<NULL>	8290	Psychotherapy for depression: paths to health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Católica de Pelotas	Universidade Católica de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-57g75kp	<NULL>	Be 18 years of age or older; both genders; residents in the urban area of Pelotas (RS); have access to the internet and an electronic device compatible with the virtual service platform (Google Meet); fulfill diagnostic criteria for current major depressive episode	Being under psychotherapeutic or pharmacological treatment elsewhere; present a risk of moderate or severe suicide; make abusive use of some psychoactive substance; have a diagnosis of bipolar disorder, schizophrenia, intellectual déficit or other severe mental disorder; present any current psychotic symptoms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-42n5gv2	Access to Radiofrequency Ablation for the Treatment of Thyroid Nodules and Thyroid Cancer	Recruiting	Intervention	2025-09-19	<NULL>	<NULL>	8291	Access to Radiofrequency Ablation for the Management of Thyroid Nodules and Thyroid Cancer in patients treated under the Brazilian Public Health System (SUS)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Instituto do Câncer Arnaldo Vieira de Carvalho	Instituto do Câncer Arnaldo Vieira de Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-42n5gv2	<NULL>	"Benign Nodule Arm
Participants older than 18 years treated at Instituto do Câncer Arnaldo Vieira de Carvalho; patients with benign nodules classified as II by fine-needle aspiration biopsy (FNAB); nodules with a diameter greater than or equal to 3 cm; nodules with a diameter greater than or equal to 2 cm associated with compressive or aesthetic symptoms with surgical indication; participants who agree to participate in the study and sign the informed consent form (ICF); patients with at least 16 months of clinical follow-up after the start of treatment
Malignant Nodule Arm
Participants older than 18 years treated at Instituto do Câncer Arnaldo Vieira de Carvalho; patients with malignant nodules classified as V or VI by fine-needle aspiration biopsy (FNAB), i.e., suspicious for or consistent with papillary carcinoma; nodules with a diameter less than or equal to 1 cm with surgical indication; participants who agree to participate in the study and sign the informed consent form (ICF); patients with at least 16 months of clinical follow-up after the start of treatment"	"Benign Nodule Arm and Malignant Nodule Arm
Participants diagnosed with hyperthyroidism; participants without cognitive ability to understand the informed consent form"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-4wqyj6h	Two shoulder surgery options to treat severe rotator cuff injuries: which works better? Lower Trapezius Transfer versus Reconstruction of the Superior Capsule	Recruiting	Intervention	2025-09-19	<NULL>	<NULL>	8292	Lower Trapezius Transfer versus Superior Capsular Reconstruction of the shoulder for the treatment of irreparable posterossuperior rotator cuff tears: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-07	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto Jundiaiense de Ortopedia e Traumatologia	https://ensaiosclinicos.gov.br/rg/RBR-4wqyj6h	<NULL>	Age between 18 and 70 years at the time of surgery. Both genders. MRI finding of a rotator cuff injury involving at least the tendons of the supraspinatus and infraspinatus muscles. MRI finding of fatty infiltration of the supraspinatus and infraspinatus muscles at stage III according to the Goutallier classification modified by Fuchs et al. Unsuccessful non-operative treatment, defined as subjective patient dissatisfaction, even after four months of continuous physical therapy	Intraoperative finding of reparability of the posterosuperior rotator cuff tear. Intraoperative finding of irreparability of any subscapularis tendon injury. Patient who does not return for at least one medical consultation after surgery. Patient who does not follow all stages of post-operative physiotherapy rehabilitation for at least six months after surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-10njv6qy	Respiratory training and Crossfit	Recruitment completed	Intervention	2025-09-18	<NULL>	<NULL>	8287	Effects of Respiratory Muscle Training on CrossFit Practitioners&apos; Performance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-15	Universidade do Estado de Minas Gerais - Unidade Passos	Universidade do Estado de Minas Gerais - Unidade Passos	https://ensaiosclinicos.gov.br/rg/RBR-10njv6qy	<NULL>	Women regularly enrolled in CrossFit practice; minimum of 1 year of experience in the modality; age between 18 and 55 years; medical clearance for physical activity; absence of respiratory diseases; no use of bronchodilator medication	Failure to complete the training protocol for any reason; absence from more than 10% of training sessions; request to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-5cghb5n	Propolis spray for the treatment of oral Mucositis	Recruiting	Intervention	2025-09-18	<NULL>	<NULL>	8288	Propolis spray for oral Mucositis in head and neck chemotherapy patients – pilot study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-05-12	Universidade Federal de Pernambuco	Hospital de Câncer de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5cghb5n	<NULL>	Patients with head and neck cancer; patients undergoing chemotherapy with or without associated radiotherapy; patients over 18 years of age of both sexes	Patients with metastasis;patients undergoing chemotherapy as palliative care; patients with allergies to propolis or any substance contained in the spray formula; patients unable to complete the questionnaires or in a serious condition that prevents them from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-4fd8f8h	Effect of cerebral electrical stimulation combined with physical exercise on pain reduction and functional improvement in individuals with knee osteoarthritis	Recruitment completed	Intervention	2025-09-18	<NULL>	<NULL>	8289	Effect of Transcranial Direct Current Stimulation combined with Lower Limb Muscle Strengthening Exercises on pain and functionality in patients with knee Osteoarthritis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4fd8f8h	<NULL>	Male and female participants; age between 50 and 75 years; symptomatic knee osteoarthritis for at least 3 months; pain score greater than 3 on the 0–10 Numeric Rating Scale (NRS); Kellgren–Lawrence classification greater than grade 1	History of cancer; patients with type I diabetes; with uncontrolled arterial hypertension; with cardiac pacemaker; presenting neurological deficits; with orthopedic surgery in the lower limbs; with body mass index above 40 kg/m²; with symptomatic hip osteoarthritis; presenting cognitive impairment; with history of brain surgery; seizure; stroke or intracranial metal implantation; who underwent craniectomy at the site of transcranial direct current stimulation application; and decompensated ventricular shunt	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-2ss7yy8	Comparison between a biomaterial and autogenous graft in the treatment of gingival recessions. Randomized controlled clinical trial	Recruitment completed	Intervention	2025-09-17	<NULL>	<NULL>	8285	Comparison between porcine acellular dermal matrix and subepithelial connective tissue graft in root coverage of gingival recessions. Randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-05	Universidade de São Paulo	Faculdade de Odontologia de Ribeirao Preto da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2ss7yy8	<NULL>	Both sexes; minimum age of 18 years; with bilateral Class I or II Miller unilateral gingival recessions greater than or equal to 3 mm in non-molar teeth; main complaint of aesthetics or unresolved dentin hypersensitivity	Systemic health compromise; contraindication for periodontal surgery; smokers; pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-4bcwft2	Evaluation of the cardiovascular response to resistance training in individuals with stroke	Data analysis completed	Intervention	2025-09-17	<NULL>	<NULL>	8286	Evaluation of the cardiac autonomic response to resistance training in individuals with stroke	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-4bcwft2	<NULL>	Women; 40 years or older; diagnosis of hemorrhagic or ischemic stroke for at least 3 months	History of acute trauma-orthopedic changes (equal to or less than 3 months) on the side not affected by the stroke; uncontrolled diseases that alter the functional capacity to carry out the training program; cognitive, visual and hearing changes that interfere with understanding commands, explanations and completing questionnaires; and attendance of less than 75% in training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9b43r9r	The effect of an intervention on common mental disorders with community health agents	Not yet recruiting	Intervention	2025-09-16	<NULL>	<NULL>	8283	Effectiveness of an intervention on common mental disorders with community health workers: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-04-05	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-9b43r9r	<NULL>	Community Health Agents, regardless of age or gender, who are affiliated with the Municipal Health Department of Uberaba and have been in professional practice for at least 12 months will be included.	Community Health Agents who are on vacation or sick leave during the development of the research will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:13
RBR-3hpp6dt	Pancreatic Steatosis in Cystic Fibrosis: Association with CFTR Modulator and Potentiator Therapy, Diabetes, and Bone Density – A Cohort Study in a Multidisciplinary Referral Center	Recruiting	Observational	2025-09-16	<NULL>	<NULL>	8284	Pancreatic Steatosis in Cystic Fibrosis: Association with CFTR Modulator and Potentiator Therapy, Diabetes, and Bone Density – A Cohort Study in a Multidisciplinary Referral Center	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-09-01	Ricardo Jacarandá de Faria	Instituto Hospital de Base do Distrito Federal - Ihbdf	https://ensaiosclinicos.gov.br/rg/RBR-3hpp6dt	<NULL>	Individuals followed at the cystic fibrosis outpatient clinic and at the pancreas outpatient clinic of HBDF will be invited for inclusion in the cohort,;with sequencing for CFTR mutations;aged over 16 years.	Individuals who have undergone pancreatectomy ;and those with alcohol consumption greater than 20 g per day.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-2t3s88z	Comparison of cost and quality of life in the treatment of varicose veins by normal surgery and by radiofrequency treatment at Hospital de Américo Brasiliense (SUS)	Data analysis completed	Intervention	2025-09-15	<NULL>	<NULL>	8278	Cost-Effectiveness and Quality of Life Study of Safena Magna Treatment by Radiofrequency Ablation and Conventional Surgery at Hospital Estadual de Américo Brasiliense (SUS)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-18	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2t3s88z	<NULL>	Symptomatic lower limb varicose veins; age over 18 and under 80; presence of total or partial reflux of the great saphenous vein of one or both or limbs, detected on duplex ultrasound with indication for surgical treatment	Significant underlying diseases in activity such as cancer, lupus, tuberculosis; infectious disease (infected ulcers); history of clotting disorders (thrombophilia); history of thromboembolic events (deep vein thrombosis); use of anticoagulant or antiplatelet medication; pregnancy; high cardiovascular risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-7thqzxp	Effect of desensitizers on the control of dental sensitivity after periodontal treatment	Terminated	Intervention	2025-09-15	<NULL>	<NULL>	8279	Effect of two desensitizing agents in the control of Dentin Hypersensitivity during and after basic periodontal treatment - clinical, randomized and blind study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-11	Colegiado de Odontologia da Universidade Estadual do Oeste do Paraná (UNIOESTE)	Colegiado de Odontologia da Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-7thqzxp	<NULL>	Patients of both sexes, between 18 and 70 years old; presence of at least two teeth with dentin hypersensitivity; presence of at least one tooth with an Analog Visual Scale score above 5 cm; presence of exposed dentin in the cervical dental region; with at least two hemiarches affected by hypersensitivity condition; probing depth up to 3 mm; Analog Visual Scale sensitivity value greater than or equal to 4 cm	Dental elements covered by prosthetic work or endodontically treated; patients in constant use or with medical history marked by chronic use of analgesics, anti-inflammatory drugs and psychotropic drugs; patients with orthodontic appliances; patients who have used desensitizers in the last three months; patient who underwent sensitive element restorative treatment for less than a month	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9f5f4yr	Transcranial Direct Current Stimulation associated with ReST for speech disorders: a randomized clinical trial	Not yet recruiting	Intervention	2025-09-15	<NULL>	<NULL>	8281	Transcranial Direct Current Stimulation associated with the ReST Method on the Treatment of Motor Speech Disorders: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-15	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	https://ensaiosclinicos.gov.br/rg/RBR-9f5f4yr	<NULL>	Study 1: Children of both sexes; ages 5 to 12 years and 11 months; speech-language pathology diagnosis of Motor Speech Delay, Childhood Apraxia of Speech, Developmental Dysarthria, or Childhood Apraxia of Speech associated with Developmental Dysarthria. Study 2: Adults of both sexes; ages 18 and older; speech-language pathology diagnosis of Apraxia or Dysarthria	Study 1: neurological diagnosis that constitutes the etiological cause of speech motor alterations such as cerebral palsy, syndromes, intellectual disability; craniofacial anomalies such as cleft lip and palate; metal implants in the skull; brain diseases such as tumors; skin diseases; failure in hearing screening performed with Transient Evoked Otoacoustic Emissions; concomitant speech-language pathology intervention; previous application of Transcranial Direct Current Stimulation. Study 2: oral comprehension deficits; failure in hearing screening performed with Transient Evoked Otoacoustic Emissions; craniofacial deformity reported or observed during the evaluation; neurological and/or psychiatric disease other than stroke; concomitant speech-language pathology intervention; previous application of Transcranial Direct Current Stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-256tk2b	Efficacy of Laser treatment for Onychomycosis: clinical trial	Recruiting	Intervention	2025-09-15	<NULL>	<NULL>	8282	Efficacy of Photodynamic Therapy in the treatment of Onychomycosis: a randomized, placebo-controlled, double-blind clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-09-01	Faculdade de Enfermagem da Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-256tk2b	<NULL>	Volunteer of both sexes; 18 to 90 years old; with Diabetes Mellitus; with laboratory-confirmed Onychomycosis	Volunteers with foot ulcers, ankle-brachial index below 0.89, Tinea Pedis; fungal skin infections; using corticosteroids; immunosuppressants; chemotherapy and/or antifungals; autoimmune diseases and Human Immunodeficiency Virus; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-8djspm4	Influence of surgical position on head pressure during general anesthesia	Data analysis completed	Observational	2025-09-12	<NULL>	<NULL>	8274	Influence of body position on intracranial pressure during general anesthesia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-10-20	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital Nove de Julho - Rede Ímpar	https://ensaiosclinicos.gov.br/rg/RBR-8djspm4	<NULL>	Patients over 40 years of age; undergoing elective gastrointestinal, urological or gynecological surgeries; without previous cognitive alterations; Signature of the consent form	Patient refusal to participate in the clinical trial; previous cognitive alterations; history of ischemic stroke or other previous neurological pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-3vcjrq5	How do individuals with HIV feel when performing Intense Exercise?	Data analysis completed	Intervention	2025-09-12	<NULL>	<NULL>	8275	Acute effect of High-Intensity Interval Training on immunological parameters, cardiac autonomic control and psychophysiological responses of people living with HIV: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Departamento de Educação Física da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	https://ensaiosclinicos.gov.br/rg/RBR-3vcjrq5	<NULL>	men with HIV; between 18 and 45 years of age; who have been on ART for at least 6 months; medical authorization to practice physical exercise; physically active for at least 1 month	Individuals with any musculoskeletal limitation that prevents exercise; history of cardiovascular disease; use of illicit drugs; smokers; alcoholics; those who did not follow the evaluation recommendations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-4hzzc5w	Effectiveness of Auriculotherapy on fatigue, sleep and quality of life in nursing students: study with data collection before and after the intervention	Recruiting	Intervention	2025-09-12	<NULL>	<NULL>	8276	Effectiveness of Auriculotherapy on fatigue, quality of life, and sleep of nursing university students: quasi-experimental study	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Federal de Santa Maria	Programa de Pós-Graduação em Enfermagem da Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-4hzzc5w	<NULL>	Students from the 4th semester to the 8th semester regularly in the nursing course and who have not had total or partial suspension of the course; students who obtain scores of poor sleep quality and high fatigue; all genders and over 18 years old	Students who are partially or completely suspended from the course will be excluded from the intervention if they are undertaking other energetic therapies (Reiki, therapeutic touch, yoga, Ayurveda, among others); use of anxiolytics; antidepressants and pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-3t734yn	Effects of Electrical Brain Stimulation along with Language Therapy in people with Speech Difficulties	Recruiting	Intervention	2025-09-12	<NULL>	<NULL>	8277	Effects of Transcranial Direct Current Stimulation associated with Language Therapy in patients with Expressive Aphasia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3t734yn	<NULL>	Patients with Expressive Aphasia; age between 25 and 65 years; both sexes	Changes of a psychic nature attested by medical opinion; presence of metal prostheses that prevent the application of Transcranial Direct Current Stimulation; presence of episodes of seizures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-92z9x85	New manual method to inflate the breathing tube balloon during anesthesia without specific devices	Recruiting	Intervention	2025-09-11	<NULL>	<NULL>	8269	Management of cuff pressure without a manometer: validation of a manual inflation method	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-06-20	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92z9x85	<NULL>	Adult patients aged 18 years or older; both sexes; classified as ASA I, II, or III, according to the American Society of Anesthesiologists; who will undergo general anesthesia with the need for orotracheal intubation; signature of the Informed Consent Form by the patient or by his/her legal representative	Patients with a history of previous tracheal disease; emergency or major surgeries involving the airway; known tracheal lesions; or the presence of anatomical abnormalities that make orotracheal intubation difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-2mp4w9m	Study assesses whether the type of restorative material used in tooth restorations influences the durability of treatments for tooth wear	Recruiting	Intervention	2025-09-11	<NULL>	<NULL>	8270	Does the consistency of fluid or regular resin influence clinical performance when restoring non-carious cervical lesions? Randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-03	Universidade Tuiuti do Paraná	Universidade Tuiuti do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2mp4w9m	<NULL>	Adult participants aged 18 years or older; presence of at least two non-carious cervical lesions (NCCLs) in vital teeth, preferably in homologous teeth, allowing for a split-mouth design; lesions must be non-retentive, with a depth of up to 2 mm, and without pulp involvement; good general and oral health; ability and willingness to attend follow-up visits; signed informed consent form prior to participation; participants of both sexes will be recruited	Teeth with active caries, restorations or fractures in the cervical region; non-vital teeth or teeth with endodontic treatment; severe gingival inflammation or periodontal disease in the area of interest; presence of parafunctional habits such as bruxism or severe occlusal interferences; use of orthodontic appliances or retainers in the regions to be treated; known allergy or hypersensitivity to any of the materials used in the study; pregnant or breastfeeding women; individuals unable or unwilling to attend follow-up visits; systemic conditions or medications that may interfere with healing or oral health	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9xyvcyn	Comparation between Passiflora Incarnata X Valeriana Officinalis for conscious sedation in extration of the wisdom teeth surgery	Data analysis completed	Intervention	2025-09-11	<NULL>	<NULL>	8272	Evaluation of the actions of Passiflora Incarnata X Valeriana Officinalis for conscious sedation in anxious patients subjected to mandibular third molar extraction - a prospective, double-blind, split-mouth, and randomized study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-07-01	Centro de Ciências da Saúde da Universidade Estadual de Maringá	Departamento de Odontologia da Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-9xyvcyn	<NULL>	ASA I and II physical classification from the American Society of Anesthesiologists; individuals aged 17 years or older; both sexes; asymptomatic bilateral impacted mandibular third molars in similar surgical positions; patients anxious about undergoing the procedure	Patients taking antidepressant and anxiolytic drugs; History of severe respiratory deficiency, obstructive sleep apnea, alcoholism, narrow-angle glaucoma, myasthenia gravis, congestive heart failure, liver and/or kidney problems, and the use of other depressant drugs; Pregnancy and/or lactation; History of local infections, such as pericoronitis; Hypersensitivity to any component of medications, substances, or materials used in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-3c34dt9	Use of low oxygen levels in preoperative individuals of Stomach Reduction surgery	Recruiting	Intervention	2025-09-11	<NULL>	<NULL>	8273	Effects of Acute Intermittent Hypoxia (AIH) technique in individuals with Obesity in outpatient preoperative preparation for Bariatric Surgery	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-08	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3c34dt9	<NULL>	Obese individuals undergoing preoperative preparation for bariatric surgery, of both sexes, aged between 18 and 60 years, living in Florianópolis and Greater Florianópolis, with no contraindications for physical exercise and agreeing to participate in the study. The adult sample will be obtained intentionally, through accessibility and volunteering.	Participants with a history of malignant and symptomatic arterial hypertension, ischemic heart disease, cancer, uncontrolled metabolic or endocrine disorders or any chronic inflammatory disease, who cannot tolerate the use of a hypoxia exposure mask, with mobility problems, with recent surgery in the last 6 months, surgical complications, psychiatric illnesses, neurological disorders, inability to perform any of the research procedures (lack of understanding or collaboration) and who request their exclusion from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:13
RBR-10n8d52v	Clinical and laboratory evaluation of Laser in the treatment of Periodontal Disease	Recruiting	Intervention	2025-09-10	<NULL>	<NULL>	8268	Clinical and microbiological evaluation of Laser Therapy in the treatment of stage III and IV Periodontal Disease patients	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-07	Universidade Federal Fluminense - Polo de Nova Friburgo	Universidade Federal Fluminense - Polo de Nova Friburgo	https://ensaiosclinicos.gov.br/rg/RBR-10n8d52v	<NULL>	Healthy volunteers; both genders; aged between 18 and 70 years; with four or more periodontal sites with probing depth greater than or equal to 6 millimeters and clinical attachment level grater then or equal to 5 millimeters non-adjacent	Hypersensitivity to the components of 0.005 percent methylene blue gel; patients who received periodontal treatment in the last six months; use of medications as anti-inflammatories and antibiotics in the last 3 months; any evidence of systemic modifying factors that may directly interfere as bias, such as: pregnant and breastfeeding women, on hormone replacement therapy, smokers, diagnosed with hyperglycemia and diabetes, osteoporosis; with HIV+ or AIDS	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-6jn3xr9	Clinical study to assess the effectiveness of the combination of Laser, Therapeutic Ultrasound, and Electrical Current associated with a Silver Nanoparticle-containing ointment in the healing of wounds in Diabetic patients	Recruiting	Intervention	2025-09-09	<NULL>	<NULL>	8264	Effects of the combination of Electrophysical Agents and Silver Nanoparticles from green synthesis in the treatment of wounds in Diabetic patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-12	Claudio Teodoro de Souza	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6jn3xr9	<NULL>	Agree to participate in the study (sign the informed consent form); diagnosis of type 1 or 2 diabetes; present chronic wounds (wounds that do not close after 6 weeks); grade 2 wound, according to Wagner&apos;s classification (DIABETIC FOOT ULCER CLASSIFICATION SYSTEMS, 2016), which is: neuropathic and deeper, often penetrating the subcutaneous tissue, has infection, but without bone involvement, purulent secretion, inflammation and cellulitis.	Ingesting any supplement that aids healing, in pre- and post-operative procedures (e.g. impact diet); infected ulcer accompanied by cellulitis; osteomyelitis; received or will receive radiation during the study; had constant alcohol abuse 3 months before the start of the research; diagnosed with cancer; presence of wounds containing necrotic tissue, slough or fibrin necrosis; and inability of the patient to continue attending the clinic during follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-9srf9vd	Effects of Auditory and Visual Stimulation on Depression Symptoms in Individuals After Bariatric Surgery	Recruiting	Intervention	2025-09-09	<NULL>	<NULL>	8265	Evaluation of the effects of Audiovisual Stimulation on Depressive-type symptoms in individuals after Bariatric Surgery: a controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9srf9vd	<NULL>	Individuals who will undergo bariatric surgery; aged between 18 and 59 years; of both sexes; residents of the municipality of Criciúma and region; and who are interested in participating in the study will be included in the study	Individuals with a history of seizures will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-96hpf7j	How Exercise and a Low-Calorie Diet can improve breathing during effort in people with Metabolic Syndrome	Data analysis completed	Intervention	2025-09-09	<NULL>	<NULL>	8266	Effect of Physical Training and Hypocaloric Diet on ventilatory efficiency during progressive exercise in patients with Metabolic Syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-15	Universidade Federal de São Paulo	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-96hpf7j	<NULL>	Sedentary women; between 18 and 50 years old; with Metabolic Syndrome, according to the National Cholesterol Education Program, Adult Treatment Panel III criteria.	Women enrolled in other physical training programs; undergoing dietary treatment; smokers; with a history of alcohol consumption; with cardiovascular disease or a metabolic condition beyond those already included in Metabolic Syndrome; with less than 75% participation in physical training sessions; who experience changes in medication during the experimental protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-3scx6qp	Effects of auricular acupuncture on mental health: a randomized clinical trial	Recruiting	Intervention	2025-09-08	<NULL>	<NULL>	8258	Effects of auriculotherapy on university students with stress, anxiety and/or depression symptoms: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-15	Universidade Estadual do Maranhão	Programa de Pós-Graduação em Biodiversidade, Ambiente e Saúde – PPGBAS/CESC/UEMA	https://ensaiosclinicos.gov.br/rg/RBR-3scx6qp	<NULL>	The target audience for the study was all students at Universidade Estadual do Maranhão Campos Caxias; students at the Caxias Campus of the State University of Maranhão, eighteen (18) years of age or older; with an express desire to volunteer for the study and with time available to complete the assessment and submit to the sessions;According to the finite population sample calculation, stratified by proportion, with a sampling error of 5% and a 95% confidence level, a sample of 118 students was estimated for the construction of the case and control groups, randomly distributed to form groups with 59 participants	Exclusion criteria include participants who rejected or feared receiving the interventions; had a history of allergy to micropore tape or seeds; had a history of photosensitivity or skin cancer in the head and neck region; used hearing aids; had ear injuries or inflammation; were pregnant or planning to become pregnant during the study period; had discontinued sessions; were enrolled in night classes; and had received any Integrative and complementary health practices in the last three months; The discontinuation criterion involves missing two consecutive sessions or missing more than ten (10) days between sessions; had an inflammatory reaction; or expressed a desire to discontinue participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-8x3tmqc	Supplementation and metabolism	Recruitment completed	Intervention	2025-09-08	<NULL>	<NULL>	8259	Effect of food supplements on oxygen consumption	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8x3tmqc	<NULL>	≥ 18 years old; classified in the international questionary of physical activity as sedentary or irregularly active; be a university student; male and female; be of any ethnicity.	Participants who take vitamin supplements, consume thermogenic foods such as coffee, and medications that may affect the results, such as anti-inflammatories and antipyretics, during the study period; food intake 10% above or below the prescribed level; do not complete all the planned steps; those who present errors in data acquisition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-39kxqtn	Efficacy of Theta-burst Stimulation in the treatment of women with Fibromyalgia	Recruiting	Intervention	2025-09-08	<NULL>	<NULL>	8261	Efficacy of Intermitent Theta-burst Stimulation in the treatment of women with Fibromyalgia: a sham-controlled clinic trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-39kxqtn	<NULL>	Fibromyalgia diagnosis; 18 to 60y; feminine gender; pain &gt; or = 4 in the numeric evaluation scale	Pregnancy; cancer; obesity level 3; metalic prosthesis; pacemaker; convulsion historic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-8j9f586	Community health worker-centered Intervention for Diabetes management in Amazonas: study protocol	Recruitment completed	Intervention	2025-09-08	<NULL>	<NULL>	8262	Intervention led by community health agents for the management of type 2 Diabetes in the interior of Amazonas	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8j9f586	<NULL>	Individuals residing in Iranduba diagnosed with type 2 diabetes mellitus. Male or female. Age 18 or older. Be registered with Primary Health Care (APS) and be accompanied by a Community Health Agent (ACS). Permanent residence in Iranduba for at least 6 months	Acute or chronic disabling illness. Pregnancy at the time of recruitment. Other serious medical conditions that may prevent participation. Acute, terminal illness or serious mental disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-10m89r69	Exercises to improve Back Pain in elderly people treated in public health services	Not yet recruiting	Intervention	2025-09-08	<NULL>	<NULL>	8263	Effectiveness of an Exercise Program for elderly people with Chronic Low Back Pain treated in Primary Health Care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-22	Universidade Federal de Juiz de Fora - UFJF	Universidade Federal de Juiz de Fora - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-10m89r69	<NULL>	Aged 60 years or older; both sexes; report chronic low back pain, defined as the presence of symptoms in the lumbar region for a period longer than three months; present a score of four or higher on the Roland-Morris Disability Questionnaire and pain intensity greater than three on the Visual Analog Scale (VAS)	Individuals presenting with radiculopathies; severe spinal pathologies such as cauda equina syndrome, fractures, or cancer; history of spinal surgery within the past 12 months; signs of cognitive impairment; pregnancy; or absolute and relative contraindications to exercise, as described in the guidelines of the American College of Sports Medicine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-7d7cycj	The Effects of Resveratrol on Postmenopausal Women with Coronary Artery Disease	Recruitment completed	Intervention	2025-09-05	<NULL>	<NULL>	8255	The Effects of Resveratrol on Sirtuins-1 and -3, Soluble Receptors for Advanced Elycation End Products, and Gene Expression of Inhibitors of Apoptosis Proteins in Postmenopausal Women with Coronary Artery Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-06	Instituto do Coração da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7d7cycj	<NULL>	postmenopausal women (more than one year of amenorrhea) aged equal or higher than 55 years; stable chronic coronary artery disease documented by coronary angiography with at least one coronary lesion with higher than 50% reduction in vascular lumen; and BMI higher than 21.9 kg/m2	dyslipidemia with plasma triglycerides level equal or higher than 500 mg/dL and total cholesterol equal or higher than 300 mg/dL; acute coronary syndrome (6 months or less); congenital heart disease; recent surgery (6 months or less); chronic renal failure, liver failure, clinically significant genetic, hematologic, rheumatic, respiratory, or metabolic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-7t6d8z5	Microneedling to improve the appearance of skin scars	Data analysis completed	Intervention	2025-09-05	<NULL>	<NULL>	8256	Treatment of Atrophic Scars with Microneedling	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Centro de Pós Graduação da Faculdade Ciências Médicas de Minas Gerais	Centro de Pós Graduação da Faculdade Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7t6d8z5	<NULL>	Patients aged between 18 and 70 years.Diagnosis of atrophic scars.Patients who provide their informed consent to participate in the study.Of both sexes	Patients who do not wish to have their data used in the study.Patients with malignant tumors.Patients who do not wish to have their data used in the study.Pregnant and breastfeeding women.Patients who are not taking contraception and have an active sex life at the time of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-7rm8p8f	Remote physical exercise for women with gestational diabetes	Recruiting	Intervention	2025-09-05	<NULL>	<NULL>	8257	Effects of remote Home-based Physical Training on Birth Weight in Neonates of women with Gestational Diabetes: clinical effectiveness trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-18	Maternidade Escola Januário Cicco - Universidade Federal do Rio Grande do Norte	Empresa Brasileira de Serviços Hospitalares	https://ensaiosclinicos.gov.br/rg/RBR-7rm8p8f	<NULL>	Age between 18 and 45; women; diagnosis of gestational diabetes mellitus (GDM) according to World Health Organization (WHO) criteria; 1st trimester ultrasound performed (11th to 13th weeks); gestational age between 14 and 26 weeks; maximum of 3 visits to High Risk Prenatal Care; medical clearance to exercise; access to smartphone; interest in participating in any of the interventions	Insulin therapy (at recruitment); chronic arterial hypertension (at recruitment); pre-eclampsia; multiple pregnancies; history of intrauterine fetal death and/or multiple miscarriages (&gt; 2); alcoholism (&gt; 2 doses of alcohol per week); smoking; orthopedic limitations; neurological, language, hearing and/or visual limitations that may hinder participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-8zypjyb	Evaluation of Patient-Controlled Pain Analgesia with Morphine versus Morphine and Clonidine in the Postoperative period of Gastric Bypass Surgery	Recruiting	Intervention	2025-09-04	<NULL>	<NULL>	8253	Evaluation of Patient-Controlled Analgesia with Morphine versus Morphine and Clonidine in the Postoperative Period of Sleeve Gastroplasty: A Randomized Double-Blind Study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-09-01	Ronainy Francieli Silva Matos	Ronainy Francieli Silva Matos	https://ensaiosclinicos.gov.br/rg/RBR-8zypjyb	<NULL>	Patients aged between 18 and 65 years; of both sexes; physical status ASA -I or II; undergoing Sleeve Gastroplasty will be studied	Patients with severe comorbidity (American Society of Anesthesiologists (ASA) physical status III or IV); cardiac arrhythmias; dilated cardiomyopathy; cardiac conduction disorder; electrolyte disorder; acid-base disorder; hypersensitivity to morphine and/or clonidine; psychiatric; hepatic; respiratory or oncological diseases; who are receiving any type of analgesic in the week prior to surgery and those who receive blood products during the study period will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-35478mr	Herbal tea as a preoperative tranquilizer: clinical trial	Data analysis completed	Intervention	2025-09-04	<NULL>	<NULL>	8254	Tea composed of herbs as a pre-operative anxiolytic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Regional Integrada do Alto do Uruguai e das Missões - URI - Campus	Universidade Regional Integrada do Alto do Uruguai e das Missões - URI - Campus	https://ensaiosclinicos.gov.br/rg/RBR-35478mr	<NULL>	Volunteers aged between 18 and 65; both sexes; who will perform elective surgery	Individuals with psychiatric disorders; gastroesophageal reflux; diabetics;pregnant women; and those with gastropathies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-99msdj3	Clinical study on the accuracy of techniques for measuring canals in baby teeth	Recruiting	Intervention	2025-09-03	<NULL>	<NULL>	8252	Evaluation of accuracy in Odontometry in deciduous teeth: a randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-99msdj3	<NULL>	Patients of both genders seeking dental treatment at the Pediatric Dentistry Clinic Bauru School of Dentistry, University of São Paulo (FOB-USP); aged between 3 and 9 years;authorized by their guardians through the signing of the Free and Informed Consent Form (FICF), and presenting at least one deciduous tooth with clinical and radiographic characteristics indicating and enabling the performance of pulpectomy. This allows for the treatment of various canals with different forms of physiological resorption typical of primary dentition, facilitating a comprehensive analysis of the accuracy of the locators. Clinically, the presence of painful symptoms; fistulas, or abscesses will be observed, along with the feasibility of performing absolute isolation and subsequent tooth restoration. Radiographically, the presence of rarefaction will be analyzed as an indicator of irreversible pulp involvement.	Children with any type of systemic health condition; teeth with previous endodontic treatment; teeth where isolation or subsequent restoration is not feasible; teeth with pulp calcification; or teeth with pathological internal or external resorptions that prevent the instrumentation of root canals.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-64vjnm5	Impact of Removing Oral Lesions with High-Power Pulsed or Continuous Diode Laser	Recruiting	Intervention	2025-09-02	<NULL>	<NULL>	8247	Oral Lesions Excised with High-Power Pulsed or Continuous Diode Laser: A Double-Blind Randomized Clinical-Pathological Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-30	Kaique Alberto Preto	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-64vjnm5	<NULL>	Patients with clinical diagnosis of benign lesions in the oral soft tissues who agree to participate in the study; age greater than 18 years; clinical indication for excisional biopsy of one or more benign oral lesions	Patients older than 80 years of age; patients with a presumptive clinical diagnosis of malignant oral lesions; lesions with diameter smaller than 0.3 mm; patients with systemic conditions that may interfere with intra- or post-operative evaluations (immunosuppression, coagulation disorders, pregnancy, uncontrolled hypertension, uncontrolled diabetes mellitus); patients allergic to dipyrone sodium monohydrate and/or triamcinolone acetonide; patients on continuous use of immunosuppressive or anticoagulant medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-5wnttvg	The role of physical exercise in brain health the body and well being in adults	Not yet recruiting	Intervention	2025-09-02	<NULL>	<NULL>	8249	Analysis of Cognitive Cardiovascular and Metabolic parameters and quality of life in adults practicing physical exercise in the community	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-15	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5wnttvg	<NULL>	this study will include adults over the age of 18 who are part of the jequié ativo program or who want to participate of their own free will in a physical exercise program in the community	pregnant women; those with severe heart disease and those with persistent hypertension will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-82fp2rx	Effect of laser treatment on the major salivary glands of patients with Hypertension and Diabetes who have dry mouth and low saliva production and its impact on quality of life	Not yet recruiting	Intervention	2025-09-02	<NULL>	<NULL>	8250	Effect of Photobiomodulation on major salivary glands of Hypertensive and Diabetic patients with Hyposalivation and Xerostomia and its impact on quality of life	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-09-10	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-82fp2rx	<NULL>	Patients over 18 years of age; hypertensive patients taking antihypertensive medications; type 2 diabetics will be included	Patients undergoing cancer treatment; patients with Sjögren&apos;s Syndrome; those with renal failure; type 1 diabetics;pregnant women; breastfeeding women; patients using anxiolytics which have xerostomia and hyposalivation as a side effect; those who present any type of photosensitivity will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-10xxmhs3	Breast Cancer Survivors with Genitourinary Syndrome benefit from vaginal treatment with Erbium Laser: clinical and histological findings	Recruitment completed	Intervention	2025-09-02	<NULL>	<NULL>	8251	Use of Erbium Yag Laser in the treatment of Vulvovaginal Atrophy in women survivors of Breast Cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Centro de Pós-Graduação da Ciências Médicas de Minas Gerais – Faculdade de Ciências Médicas	Centro de Pós-Graduação da Ciências Médicas de Minas Gerais – Faculdade de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-10xxmhs3	<NULL>	Women patient aged between 30 and 70 years.History of hormone-dependent breast cancer and use of hormone blockers. End of chemotherapy treatment.Patients who give their informed consent to take part in the study.Patients with at least 3 symptoms of genitourinary menopausal syndrome (GMS)	Patients who do not wish to have their data used in the study.Patients who refuse to undergo biopsy and cytological examination before or after treatment.Patients under 30 and over 70.Patients undergoing chemotherapy.Pregnant and breastfeeding women.Patients who do not have at least 3 symptoms of genitourinary menopausal syndrome (GMS).Patients who have already undergone previous vaginal laser treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-6vp3srs	Effect and safety of using Pregabalin to reduce Pain after Hemorrhoid Surgery	Recruiting	Intervention	2025-09-01	<NULL>	<NULL>	8242	Efficacy and safety of perioperative use of Pregabalin in reducing Pain and Rectal Tenesmus after Hemorrhoidectomy: a randomized double-blind clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-05-05	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-6vp3srs	<NULL>	Patients over 18 years old; internal hemorrhoidal disease grades III and IV; preoperative hemorrhoidectomy at Hospital Carlos Macieira	Patients with a history of allergy to Pregabalin; who cannot adequately answer the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-3dcmtnm	The action of Bach flower therapy on the occupational stress of nursing technicians working in an Intensive Care Unit, based on Betty Neuman&apos;s theory: randomized clinical trial	Recruiting	Intervention	2025-09-01	<NULL>	<NULL>	8243	Effect of Bach floral remedies on occupational stress of nursing technicians in the light of Betty Neuman&apos;s theory: Randomized Clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Departamento de Enfermagem da Universidade Federal de Pernambuco - Campus Recife	Universidade Federal de Pernambuco - Campus Recife	https://ensaiosclinicos.gov.br/rg/RBR-3dcmtnm	<NULL>	Nursing technicians; aged between 25 and 65 years; have worked in an adult Intensive Care Unit for at least 3 months; are not undergoing any treatment for stress	Nursing technicians who: are on leave, maternity leave or for health treatment; change work sector; Technician who is not part of the Intensive Care Unit staff who is taking vacation, leave and other activities will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-5r67whx	Premature ovarian insufficiency associated with hypertension and cardiovascular effects - hormonal replacement therapy and physical training as treatments	Not yet recruiting	Intervention	2025-09-01	<NULL>	<NULL>	8244	Premature Ovarian Insufficiency associated with hypertension and hemodynamic, autonomic, morphological and cardiac functional effects - Hormonal Replacement Therapy and Physical Training as countermeasures	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo - FMRP/USP	Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo - FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-5r67whx	<NULL>	The study included normotensive and hypertensive women in two different age groups: 25 to 45 years old, and 55 to 65 years old. The younger group included women with preserved ovarian function, as well as women with premature ovarian failure who had undergone hormone replacement therapy for at least two years. The older group included women who had undergone physiological menopause, as well as women with premature ovarian failure who had undergone hormone replacement therapy until the age of physiological menopause (around 51 years).	Volunteers presenting any of the following conditions will not be included in the study: uncontrolled hypertension,  cognitive impairment preventing understanding of the tests and aerobic physical training, musculoskeletal changes preventing physical training, endocrine, metabolic and cardiovascular diseases, such as coronary artery disease and arrhythmias Smokers, individuals using drugs that interfere with cardiac function and cardiovascular autonomic control (e.g. beta-adrenergic blockers), and those using hormone replacement therapy will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-7t3j7x6	Effect of Manual Techniques on pain and movement in people with problems in the jaw region	Recruiting	Intervention	2025-09-01	<NULL>	<NULL>	8245	Effect of Manual Therapy on Pain Intensity and Mobility of Individuals with Temporomandibular Disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-04	Universidade São Francisco	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7t3j7x6	<NULL>	Age between 18 and 50 years; both genders; report pain greater than or equal to 4 on the Numerical Pain Scale (NPS greater than or equal to 4) in the temporomandibular joint region, not requiring clinical diagnosis, for a period equal to or greater than 3 months intermittently, that is, with intervals in which the pain ceases; pain/discomfort in the masseteric region and head and neck, associated with pain in the temporomandibular joint region, for a period equal to or greater than 3 months intermittently, that is, with intervals in which the pain ceases	Use any type of anti-inflammatory medication; use any type of orthodontic retainer plates	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-7dpnb52	Effects of a physical exercise program for the elderly	Recruitment completed	Intervention	2025-09-01	<NULL>	<NULL>	8246	Active aging: effects of an exercise program	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-17	Profa. Dra. Iane de Paiva Novais	Universidade Estadual do Sudoeste da Bahia - UESB	https://ensaiosclinicos.gov.br/rg/RBR-7dpnb52	<NULL>	Be female; be between 45 and 75 years old; be post-menopausal, have not had a menstrual cycle for at least 12 months and present a medical certificate authorizing the practice of physical activity	Being a smoker; not having control over blood pressure or blood sugar levels; using hormone replacement therapy and having a contraindication to performing physical exercises, identified through the Physical Activity Readiness Questionnaire (PAR-Q)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-8dcymd4	Assessment of the female intimate area before and after the use of treated and untreated menstrual pads	Recruiting	Intervention	2025-08-29	<NULL>	<NULL>	8239	Crossover clinical study to evaluate the potential of a pH-buffered, prebiotic treated menstrual pad to provide benefits to the skin and intimate microbiome (E008750A)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-22	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8dcymd4	<NULL>	Females; 18 to 45 years old; in good general health, with regular monthly menstrual cycles; who menstruates up to 5 to 6 days. Participants must have healthy and intact skin in the test areas and be willing to comply with study requirements	Participants who are pregnant or intending to become pregnant during the study; history of chronic or currently active gynecological pathologies or urogenital infections in the last 3 months; used systemic and/or topical antibiotics, antifungals, and/or corticosteroids within 4 weeks prior to visit 1; any other medical condition or history that may compromise the study results or the subject’s safety	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-5c7z52w	Study on two types of Intrauterine Devices - IUD for protection of the uterus in women in menopause	Not yet recruiting	Intervention	2025-08-29	<NULL>	<NULL>	8240	Randomized clinical trial with two different types of Levonorgestrel IUD for endometrial protection in women using Estradiol hormone therapy for vasomotor symptoms during menopause	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2025-09-10	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-5c7z52w	<NULL>	Postmenopausal patients or  those transitioning to menopause; aged 48 or over; with Follicle-Stimulating Hormone FSH dosage greater than or equal to 25; with indication for hormonal therapy; who have a uterus; no contraindications to the use of Intrauterine Devices; with a mammogram no more than 1 year ago classified as Breast Imaging Reporting and Data System (BIRADS) 1/2 or 3	Previous use of Hormone Therapy; refusal to participate in the study; Endometrial line greater than or equal to 5 mm in women with more than one year since the last menstruation (post-menopause); abnormal uterine bleeding of structural cause (polyp, leiomyoma, adenomyosis, suspected endometrial malignant neoplasm) in women in the menopausal transition; contraindications to the use of Hormone Therapy (breast cancer, endometrial cancer, hormone-dependent ovarian cancer, history of stroke, history of ischemic heart disease, active liver disease, thrombosis, or acquired or hereditary thrombophilia, porphyria, meningioma); uterine malformations, intracavitary changes of the uterus; patient under investigation for hormone-dependent neoplasia or precursor lesion during the study follow-up; personal history of thromboembolism or diagnosis of thrombophilia; personal history of angina, stroke or myocardial infarction; active liver disease; hypersensitivity to the components of the medications used in the study; porphyria; neurological or psychiatric diseases that make it impossible to follow the study instructions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-9xt9t5r	Do Abdominal Exercises help close muscle separations after childbirth?	Not yet recruiting	Intervention	2025-08-29	<NULL>	<NULL>	8241	Can Core Training reduce the inter-rectic distance in postpartum women with diastasis? randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9xt9t5r	<NULL>	The study will include women over 18 years of age with diastasis recti abdominis. Those with a distance of 2.8 cm between the muscle bellies at rest or 2.5 cm during flexion will be considered eligible. Furthermore, all volunteers with visible abdominal bulging on ultrasound will be included, regardless of the inter-rectus distance. Participants must be between 6 and 24 months postpartum, have no history of abdominal plastic surgery or umbilical hernia repair, have no abdominal wall hernia, have no low back pain, and are not pregnant. They must also not participate in other resistance exercise programs	Participants who, during training, become pregnant or develop any clinical condition that poses a health risk and compromises continued participation in the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-42pbbqq	Effect of Spinning Babies® techniques on labor duration and cesarean section rates	Recruiting	Intervention	2025-08-28	<NULL>	<NULL>	8235	Effect of Spinning babies® on labor progression and cesarean delivery rates	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-05	Universidade Federal de Santa Catarina	hospital de clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-42pbbqq	<NULL>	Pregnant women aged 18 years or older; Pregnancy with a gestational age of 37 weeks or more;Singleton pregnancy with the fetus in a cephalic presentation; Nulliparous pregnant women with intact or ruptured amniotic membranes in spontaneous labor; Pregnant women with the fetus in the mid-pelvic plane, i.e., at De Lee stations -1, 0, or +1.	Pregnant women with a history of practicing Spinning Babies® within the last 24 hours; pregnant women who have undergone any type of pharmacological induction; pregnant women with any communication or comprehension barriers regarding the Portuguese language; pregnant women with physical limitations or contraindications that prevent them from performing Spinning Babies® exercises; and pregnant women accompanied by doulas.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:46
RBR-10fqpzdg	Evaluation of the use of artificial saliva to prevent mouth lesions in patients admitted to an intensive care unit	Terminated	Intervention	2025-08-28	<NULL>	<NULL>	8236	Evaluation of the effectiveness of the use of artificial saliva in the prevention of oral changes in patients admitted to an intensive care unit	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Hospital Geral João Machado	https://ensaiosclinicos.gov.br/rg/RBR-10fqpzdg	<NULL>	Patients over 18 years of age; of both sexes; patients undergoing dental examination within the first 24 hours of admission to the Intensive Care Unit; patients with no history of autoimmune diseases; without sepsis; without current pregnancy; without known sensitivity to ingredients of the gel used; without evident oral or perioral changes or lesions on examination upon admission to the Intensive Care Unit; patients totally dependent on professional care	Patients whose oral examination cannot be performed (limitation of mouth opening or other factor); patients who were already hospitalized in the Intensive Care Unit of another service	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-22pz6cb	Which works better for Sore Gums in teenagers Green Propolis or Mouthwash	Recruitment completed	Intervention	2025-08-28	<NULL>	<NULL>	8237	Comparative analysis between the action of Chlorhexidine and Green Propolis on Gingivitis in adolescents	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal de São João Del Rei - Campus Centro Oeste Dona Lindu	Secretaria Municipal de Saúde de Divinópolis/MG	https://ensaiosclinicos.gov.br/rg/RBR-22pz6cb	<NULL>	Individuals of both sexes; aged between 10 and 65 years; treated at the Family Health Strategy of Vale do Sol in Divinópolis; presenting gingival bleeding according to the Community Periodontal Index; with gingivitis and gingival probing depth up to 3 mm; presenting periodontitis and absolute periodontal pocket depth greater than 3 mm; presenting bone loss, confirmed by radiography	Pregnant women or those who are breastfeeding; individuals using antimicrobials or anti-inflammatory drugs; individuals with severe tooth mobility due to extensive coronal destruction; individuals wearing removable partial dentures, as assessed in the questionnaire; individuals without minimal autonomy, due to mental or consciousness impairments, according to the interviewer’s subjective evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-9kfnshy	Effects of a Conventional Cardiovascular Rehabilitation protocol compared to the use of Game therapy in participants with type 2 Diabetes	Not yet recruiting	Intervention	2025-08-28	<NULL>	<NULL>	8238	Effects of a Conventional Cardiovascular Rehabilitation protocol versus adapted to Virtual Reality in participants with type 2 Diabetes: Controlled and randomized study protocol	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9kfnshy	<NULL>	Individuals age eighteen and over; both genders; without Pulmonary diseases and Peripheral arterial obstructive disease; those who undergo regular monitoring by an angiologist and endocrinologist; residents in the city of Natal / RN; who are not enrolled or have participated in the last six months prior to the study in any Cardiovascular rehabilitation program	Individuals with acute or uncontrolled Congestive heart failure; individuals with unstable or uncontrolled Angina; individuals with uncontrolled Cardiac arrhythmia causing hemodynamic symptoms; subjects with severe symptomatic Aortic stenosis; individuals with Deep venous thrombosis; individuals with recent Pulmonary embolism; individuals with Pericarditis or Acute myocarditis; individuals with Dissected aneurysms (known or suspected); individuals with unstable or uncontrolled Blood pressure (systolic pressure greater than one hundred sixty millimeters of mercury and diastolic pressure greater than one hundred millimeters of mercury); individuals with Acute systemic infection or uncontrolled Diabetes; individuals with limitations due to Musculoskeletal diseases or Cognitive difficulty in understanding activities; individuals who present Sweating and/or Dizziness during the evaluation and/or exercise Protocol, peripheral oxygen desaturation during the Step test below ninety percent; individuals who drop out or miss two consecutive Training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-7qyc4vy	The effects of Respiratory Physiotherapy in children and adolescents with Pneumonia	Recruiting	Intervention	2025-08-27	<NULL>	<NULL>	8234	Effects of Positive Pressure and Pressure Redirection Technique on Lung Aeration and Function in Children and Adolescents with Community-Acquired Pneumonia: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qyc4vy	<NULL>	Children; adolescents; both genders; age between 0 and under 18 years; admitted to the pediatric ward; diagnosed with pneumonia	Diagnosis of chronic respiratory diseases; diagnosis of respiratory failure; need for ventilatory support; need for transfer to Intensive Care Unity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-8vv7yzq	Effects of physical exercise on shoulder recovery and arm swelling in women after breast cancer surgery	Recruitment completed	Intervention	2025-08-26	<NULL>	<NULL>	8231	Physical Exercise as a complementary therapy in the care of individuals with Cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade do Estado de Mato Grosso - UNEMAT	Universidade do Estado de Mato Grosso - UNEMAT	https://ensaiosclinicos.gov.br/rg/RBR-8vv7yzq	<NULL>	Women; aged 18 years or older; without cognitive alterations and able to understand the Informed Consent Form (ICF); diagnosed with breast cancer; undergoing treatment; capable of physical exercises; with a medical certificate for physical activity	Patients with untreated/acute deep vein thrombosis; high fever; blood alterations (platelet/hemoglobin below reference); active bleeding; needing a walking aid; difficulty understanding instructions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-2sg4d8v	The result of treating Depression in university students through Acupuncture	Recruitment completed	Intervention	2025-08-26	<NULL>	<NULL>	8232	Effect of Acupuncture on the treatment of Depression and on oxidative stress parameters: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2sg4d8v	<NULL>	Students of the Health Sciences Center of the State University of Western Paraná, in Francisco Beltrão; aged between 18 and 60 years; both sexes; self-reported depressive symptoms, investigated through the application of the Patient Health Questionnaire; who agree to answer the questionnaires and sign the Free and Informed Consent Form (FICF)	History of neoplasia; thrombosis; autoimmune diseases; pregnancy; indication of absence of depression and severe depression, in the Patient Health Questionnaire-9; who are undergoing treatment for cardiovascular diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-5xtmybg	Oral Plus Mouth Rinse in the management of Chemotherapy-Induced Oral Mucositis	Recruiting	Intervention	2025-08-25	<NULL>	<NULL>	8226	Randomized clinical trial to evaluate the effect of Oral Plus Mouth Rinse in the management of Chemotherapy-Induced Oral Mucositis: a pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	União Brasileira de Educação e Assistência	União Brasileira de Educação e Assistência	https://ensaiosclinicos.gov.br/rg/RBR-5xtmybg	<NULL>	Participants of both sexes; aged 18 years or older; diagnosed with solid or hematological malignant neoplasms and indicated for chemotherapy with cisplatin, cytarabine, bleomycin, etoposide, 5-fluorouracil (5-FU), doxorubicin, melphalan, busulfan, vincristine, daunorubicin, mercaptopurine, gemcitabine, cyclophosphamide, methotrexate, or capecitabine – these chemotherapeutic agents may be administered alone, in combination, or concurrently with other drugs, including immunotherapies and targeted therapies; chemotherapeutic agents administered orally, intravenously, subcutaneously, or intrathecally at intervals of no more than 21 days; capable of providing written informed consent, demonstrating full understanding of the study’s objectives, procedures, and potential risks; with an Eastern Cooperative Oncology Group (ECOG) Performance Status of 2 or less	Individuals who do not agree to participate or do not sign the Informed Consent Form (ICF); have a history of radiotherapy in the head and neck region; have a history of hypersensitivity or allergy to the components of the Oral Plus mouthwash; have severe systemic diseases such as hepatic or renal failure, uncontrolled autoimmune diseases, or other conditions that may interfere with participation or interpretation of the study results; are concurrently using other specific treatments for oral mucositis, such as medicinal mouthwashes or alternative therapies targeted at mucositis; are pregnant or breastfeeding; have participated in another clinical trial that may interfere with the results of this study within 30 days prior to enrollment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-85t3hdf	Cognitive Behavioral Intervention in patients with weight regain after Bariatric Surgery: a controlled clinical study in group and online formats	Terminated	Intervention	2025-08-25	<NULL>	<NULL>	8227	Cognitive Behavioral Group and Online intervention for patients with weight regain after Bariatric Surgery: a controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-05	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-85t3hdf	<NULL>	Aged between 30 and 65 years; both sexes; bariatric surgery performed in 2018 at the Hospital das Clínicas, Faculty of Medicine, University of São Paulo (USP); availability to participate in the sessions and assessments; internet access (for the virtual group)	Age under 30 or over 65 years; pregnancy; physical or cognitive impairment preventing participation in the sessions; refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-6n3crpc	Involvement of the areola and nipple in women with Breast Cancer: what clinical exams, imaging, and surgical analysis reveal	Recruiting	Observational	2025-08-25	<NULL>	<NULL>	8228	Aerolopapillary complex involvement in Breast Cancer patients: correlation between clinical, radiological and pathological findings in Mastectomy specimens	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-18	Hospital Israelita Albert Einstein - São Paulo	Hospital Israelita Albert Einstein - São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6n3crpc	<NULL>	Women over 18 years old with a diagnosis of Breast Carcinoma; Women with an indication for Mastectomy with excision of the nipple-areola complex	Nipple-areola complex presenting with clinical ulceration; Inflammatory carcinoma; Treatment performed at another institution; Refusal to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-9tqzmsw	New Advances in Tracking Aging through Lifestyles in Long-Lived People (NATAL Study):prospective cohort	Recruiting	Observational	2025-08-25	<NULL>	<NULL>	8229	NATAL Study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Pós-Graduação em Educação Física da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9tqzmsw	<NULL>	Both genders; be 80 years or older; have no severe cognitive impairment, assessed by the MoCA (Montreal Cognitive Assessment); live in the community, i.e., not residing in a long-term care facility; be able to walk with or without assistive devices; be able to perform basic activities of daily living independently or with partial dependence, considering a Katz index score greater than 2	Uncontrolled blood pressure (above 160/105 mmHg); decompensated diabetes (fasting glucose above 250 mg/dL); severe language, hearing and/or vision impairments that may prevent participation in the study; history of recent cardiovascular events (less than six months); severe and/or unstable cardiovascular diseases (e.g., unstable angina, severe or uncontrolled arrhythmias, myocardial infarction, coronary artery disease, stroke, deep vein thrombosis, peripheral arterial disease, pacemaker use or heart failure); severe and limiting lung diseases (such as chronic obstructive pulmonary disease, pulmonary emphysema, chronic bronchitis or asthma); chronic kidney disease requiring dialysis; severe or serious neurological diseases (such as Parkinson&apos;s, multiple sclerosis or Alzheimer&apos;s); history of cancer with treatment in the last six months; signs or symptoms of any acute health condition and/or hospitalization in the last four weeks (e.g., flu, infection, virus); any medical contraindication to performing moderate to vigorous physical activity; refusal to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-4twbg5t	Effect of delayed insertion of bulk-fill resin on pain after restorations in posterior teeth	Recruiting	Intervention	2025-08-25	<NULL>	<NULL>	8230	Effect of Decoupling With Time on Postoperative Sensitivity of bulk-fill resin restorations in posterior teeth: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-12	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4twbg5t	<NULL>	Individuals of both sexes. Minimum age of 18 years. Individuals in good general health who have at least one vital posterior tooth, whose vitality can be confirmed by means of a cold stimulation test, in need of restoration due to carious lesions or replacement of an inadequate previous restoration due to aesthetic reasons, fracture or secondary caries. The tooth of interest must necessarily have an opposing tooth in occlusion. The cavities must present occlusal involvement (class I and II) and be at least 4 mm deep, measured at the time of screening using bitewing radiographs and a millimeter ruler and at the time of intervention by measuring the cavity after preparation	Pregnant women; lactating women; those with uncontrolled systemic diseases or who report hypersensitivity to the components of the materials used in the intervention; individuals who have severe periodontitis; non-carious cervical lesions; poor oral hygiene; conditions that may alter the perception of pain, such as neuropathies, chronic pain disorders, severe bruxism and continuous use of medications such as analgesics and anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-2qcddnp	Analysis of the incidence, severity and temporal evolution of motion sickness after using the C-95M Flight Simulator	Not yet recruiting	Intervention	2025-08-22	<NULL>	<NULL>	8224	Analysis of the incidence, severity and temporal evolution of Simulator Sickness after exposure to the C-95M flight trainer: an exploratory experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-25	Comando da Aeronáutica	Base Aérea de Natal	https://ensaiosclinicos.gov.br/rg/RBR-2qcddnp	<NULL>	Healthy volunteers; both genders; trainee pilots of the transport aviation of the Natal Air Base	Be medically exempt from aerial activity or simulator training for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-3j3mkjt	Effect of Vaginal Estrogen cream in patients with Cervical Cancer treated with Radiotherapy	Recruitment completed	Intervention	2025-08-21	<NULL>	<NULL>	8223	Effect of Topical Estrogen on the vaginal epithelium of patients with Cervical Cancer treated with Radiotherapy: a randomized pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-21	Instituto de Medicina Integral Professor Fernando Figueira	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-3j3mkjt	<NULL>	"Women aged between 18 and 55 years; Histological diagnosis of cervical carcinoma stages I to IIIc2;
Radiotherapy treatment including external beam radiotherapy with a total dose used between 45 and 50.4Gy and brachytherapy with a total dose used between 24 and 28Gy; No personal history of neoplasia, except non-melanoma skin"	Women with comorbidities that contraindicate the use of vaginal estrogen; Patients undergoing surgical treatment for cervical cancer; Persistent disease on gynecological examination after the thirtieth day after the end of radiotherapy treatment; Histological diagnosis of small cell cervical cancer.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-3b7r96q	Methadone and morphine: effects on the quality of recovery after abdominal plastic surgery	Recruitment completed	Intervention	2025-08-20	<NULL>	<NULL>	8218	Effect of Methadone compared to Morphine on the quality of anesthesia recovery after Abdominoplasty	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Regional Integrada do Alto do Uruguai e das Missões	Universidade Regional Integrada do Alto do Uruguai e das Missões	https://ensaiosclinicos.gov.br/rg/RBR-3b7r96q	<NULL>	Perform abdominoplasty surgery at Hospital Unimed de Erechim with the team of plastic surgeons led by Dr. Cassiano Furtado Beller. Both sexes	Have serious psychiatric disorders. Being allergic to opioids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-10yqvvp6	Effect of a natural solution based on licuri oil on improving the cleaning and hygiene of complete dentures	Recruiting	Intervention	2025-08-20	<NULL>	<NULL>	8219	Efficacy of a licuri (Syagrus coronata) oil-based solution for biofilm control in complete dentures: a crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10yqvvp6	<NULL>	Adult patients; both genders; bimaxillary completely edentulous; users of complete dentures fabricated with heat-polymerized acrylic resin; in good general and oral health; intact and healthy mucosa without signs or symptoms of denture stomatitis; use of well-fitting dentures; availability to attend the clinic during intervention and data collection periods	Participants with hypersensitivity to sodium hypochlorite; smokers; history of untreated xerostomia or hyposalivation; participants with dentures installed less than 3 months ago; participants with broken, fractured, or relined dentures; participants lacking cognitive capacity to understand and follow the experimental protocol or respond to the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-2sw2gg4	The use of different mucosal substitute surgical techniques for root coverage of multiple gingival recessions	Recruitment completed	Intervention	2025-08-20	<NULL>	<NULL>	8220	The use of individual porcine acellular dermal matrix or not in the treatment of multiple bilateral gingival retractions. Clinical, randomized, double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade de São Paulo	Faculdade de Odontologia de Ribeirao Preto da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2sw2gg4	<NULL>	Patients over 18 years of age; both sexes;full mouth biofilm and bleeding score equal to or less than twenty percent; bilateral Cairo RT1 gingival recessions on three adjacent teeth greater than or equal to 2mm; main complaint esthetics or dentin hypersensitivity	Patients with systemic health problems; contraindication for periodontal surgery; smokers; pregnant or lactating women; previous root covering surgery at the experimental site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-4qmbypq	Immediate effects of electromassage for pain relief in hemato-oncological patients	Recruiting	Intervention	2025-08-20	<NULL>	<NULL>	8221	Immediate effects of electromassage for pain relief in hemato-oncological patients: a randomized controlled crossover clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-05	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4qmbypq	<NULL>	Patients of both sexes diagnosed with hematologic cancer (leukemia, lymphoma, or multiple myeloma) undergoing active treatment (chemotherapy, immunotherapy, or radiotherapy); aged between 18 and 60 years; patients experiencing pain resulting from the tumor itself, from cancer treatment, or associated with the tumor (e.g., being bedridden or performing daily activities), regardless of location, with intensity greater than or equal to 4 on the Visual Analogue Scale, within the previous 24 hours; patients with the ability to verbally communicate in Portuguese; patients capable of providing informed consent; patients scoring between 0 and 3 on the ECOG-PS (Eastern Cooperative Oncology Group Performance Status).	Illiterate individuals; patients with psychiatric or cognitive disorders as determined by the opinion and/or follow-up of the attending psychologist; patients with hearing impairments that prevent comprehension of verbal instructions; pregnant or breastfeeding women; patients experiencing pain not directly or indirectly related to the tumor (i.e., chronic low back pain or pain resulting from musculoskeletal diagnoses such as arthritis or arthrosis); patients receiving other analgesic therapies such as radiation, bone cement, or nerve block therapy; individuals with known contraindications to massage therapy, including spinal tumors, known hematologic coagulation disorders (such as hemophilia, Von Willebrand disease, or thrombocytopenia), paresthesia, injuries (open wounds), post-surgical regions, catheters, and deep vein thrombosis (DVT); individuals with known contraindications to electrical stimulation, such as metallic electronic implants like pacemakers or metal at the electrode site, implanted neuromodulation devices, individuals with epilepsy or arrhythmia, dermatological conditions or fragile skin at the application site, and history of allergy to electrodes; use of analgesic or opioid medication during the intervention and data collection period (2 hours), outside of the patient’s regular prescription.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-10tb5d7g	Nutritional assessment of public school students in the city of Campinas/SP	Recruiting	Observational	2025-08-20	<NULL>	<NULL>	8222	Assessment of the nutritional status of children and adolescents enrolled in public schools in Campinas/SP	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Estadual de Campinas	Prefeitura Municipal de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10tb5d7g	<NULL>	Ages 6 to 15; students in municipal schools; elementary school I; elementary school II	students with psychological disorders; students with social disorders; failure to sign the consent form; physical disabilities that make anthropometric assessment impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-4nqkkvk	Study on the use of high and low power lasers in the treatment of temporomandibular joint disorders	Not yet recruiting	Intervention	2025-08-19	<NULL>	<NULL>	8216	Comparison of high and low power diode laser in the therapeutic treatment of patients with Temporomandibular Dysfunction (TMD): a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Pontificia Universidad Catolica Madre y Maestra	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4nqkkvk	<NULL>	Patients over 18 years of age, Both genders male and female, Patients included in the Research Diagnostic Criteria for temporomandibular joint disorders (RDC/TMD); Patients with pain and symptomatology in the temporomandibular, orofacial and craniocervical regions; patients with or without limitation of jaw movements, opening and laterals; patients with or without presence of noise in the Temporomandibular Joint	Patients with congenital conditions and neoplastic conditions involving alterations in the temporomandibular joint and in orofacial and craniocervical regions; Patients with a history of recent trauma in the orofacial and craniocervical region; Patients with current use of myorelaxant plates for the treatment of temporomandibular disorders; Patients with functional orthopedic appliances or fixed or removable orthodontic appliances; Patients with cleft lip or palate; Patients with psychiatric disorders; Patients with severe cardiovascular problems; Patients with severely precarious oral and dental conditions such as periodontitis and in need of endodontic treatment; Patients using topical or systemic photo-sensitizing medications; Patients with dermatological diseases in the orofacial and craniocervical region; Pregnant women; Patients with severe oral and dental conditions such as periodontitis and in need of endodontic treatment; Patients who use topical or systemic photo-sensitizing medications; Patients with dermatological diseases in the orofacial and craniocervical region; Women in a state of pregnancy; Patients who use topical or systemic photo-sensitizing medications; Patients who are in need of endodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-92p7tkx	Factors related to preference and adherence to Walking and Strength Training in women with Fibromyalgia	Recruiting	Intervention	2025-08-19	<NULL>	<NULL>	8217	Factors associated with and mediators of preference for and adherence to Aerobic or Resistance Training in women with Fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-04	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-92p7tkx	<NULL>	Women aged between 18 and 55; diagnosed with fibromyalgia; able to speak, read and understand Brazilian Portuguese well	Women with neurological conditions that interfere with assessments, such as paralysis, significant sensory changes, and changes in level of consciousness/understanding;joint diseases that directly interfere with participation in interventions; suspected thrombosis, heart disease, and immediate postoperative conditions; pregnancy; alcohol and illicit substance abuse; and active cancer; prior physical therapy treatment (less than or equal to 6 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-29fjs5r	Clinical study of two biomaterials used to control bleeding after extraction of mandibular third molars	Data analysis completed	Intervention	2025-08-18	<NULL>	<NULL>	8213	Randomized clinical study of two hemostatic agents in dental socket of mandibular third molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-01	Programa de Pós-Graduação em odontologia da Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-29fjs5r	<NULL>	The physical criteria included research participants with bilateral third molars indicated for extraction; aged between 18 and 40 at the time of recruitment; both genders; the psychological criteria for participation in the project comprised patients with no history of anxiety; mood; eating; or psychotic disorders that could compromise their participation and collaboration in the study; these were evaluated by completing an anamnesis form	All research participants who smoked; were dependent on alcohol; had systemic diseases (eg, diabetes, blood dyscrasias) were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-5p9w6vz	Evaluation of fixed combination strategies with three drugs in low/moderate doses versus two drugs in moderate/high doses for blood pressure control	Recruiting	Intervention	2025-08-18	<NULL>	<NULL>	8214	Randomized trial to evaluate fixed combination strategies with three drugs at low/moderate doses versus two drugs at moderate/high doses and their action on peripheral and central blood pressure parameters, arterial stiffness and endothelial function	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2024-08-14	Barroso e Sebba Ltda	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5p9w6vz	<NULL>	Patient over 18 years of age; both sexes; hypertension being treated with a double combination of antihypertensive drugs and Systolic Blood Pressure - SBP greater than 140 mmHg or Diastolic Blood Pressure - DBP greater than 90mmHg	Any clinical observation finding (clinical/physical evaluation) or laboratory condition that is interpreted by the investigating physician as a risk to participation in the clinical trial or presence of uncontrolled chronic disease(s); history of alcohol or illicit drug use disorder in the last 2 years; women of childbearing potential who are not using a reliable contraceptive method or who are pregnant, breastfeeding or planning to become pregnant; known allergy or hypersensitivity to the components of the drugs used during the clinical trial; known renal insufficiency, with estimated Glomerular Filtration Rate - GFR persistently lower than 30 mL/min/1.73 m2 - by the CKD-EPI equation; participation in clinical trial protocols in the last 12 (twelve) months, unless the investigator judges that there may be a direct benefit to them; known allergy or hypersensitivity to the components of the drugs used during the clinical trial	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-99c9hxc	Analysis of inflammation in patients with diseases around dental implants before and after treatment	Recruiting	Intervention	2025-08-18	<NULL>	<NULL>	8215	Evaluation of cytokine expression in patients with Mucositis and Peri-implantitis before and after treatment	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-05	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-99c9hxc	<NULL>	Individuals over 18 years of age; both genders; non-smokers; systemically healthy or medically controlled; partially edentulous, with at least two osseointegrated implants presenting peri-implant disease (peri-implant mucositis or peri-implantitis); with implant-supported prostheses in function for at least six months	Individuals who received periodontal or peri-implant treatment up to six months prior to the start of the study; pregnant or breastfeeding patients; smokers; individuals who used antibiotics and/or anti-inflammatory drugs in the past three months; those who used antiresorptive medications in the past two years; or who underwent radiotherapy, chemotherapy, or iodine therapy in the past two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-33jxjcr	Comparison between Classical and Modified Mandibular Osteotomy. A Randomized Clinical Trial	Recruiting	Intervention	2025-08-15	<NULL>	<NULL>	8209	Comparison between Conventional and Modified Sagittal Split Osteotomy of the Mandibular Rami	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital Universitário Oswaldo Cruz	Hospital Universitário Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-33jxjcr	<NULL>	Patients with facial Pattern II or the sagittal component of Pattern II; Patients who sought outpatient care for the reported problem at Oswaldo Cruz University Hospital; Be at least 18 years of age. Individuals of both sexes will be included in the sample.	Patients who have not signed the consent form or with: Incomplete documentation; Trauma sequelae; Craniofacial syndromes; Disabling systemic comorbidities; In treatment of OSAS through other modalities; Presence of an impacted, impacted or out-of-occlusion third molar; Need for reoperation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-833prgf	Study on taste changes and the effect of therapeutic light in Breast Cancer patients undergoing chemotherapy	Recruiting	Intervention	2025-08-15	<NULL>	<NULL>	8210	Influence of Polymorphism of Tumor Necrosis Factor Alpha and its receptors on the risk of Dysgeusia and resistance to Preventive Photobiomodulation in Breast Cancer Patients treated with Doxorubicin and Cyclophosphamide: a randomized, triple-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-19	Instituto do Câncer do Ceará	Instituto do Câncer do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-833prgf	<NULL>	Patients over 18 years of age with stage II, III, or IV breast cancer; with no prior chemotherapy treatment; undergoing their first adjuvant, neoadjuvant, or palliative treatment with drug protocols from the anthracycline and alkylating agent classes	Patients with a history of head and neck radiotherapy; smokers; those with untreated anemia or diabetes mellitus; those using drugs that significantly alter salivary flow, saliva composition, or taste; those using centrally acting analgesics, anxiolytics, or antidepressants. Patients with a previous history of dysgeusia or with alterations in smell and taste following COVID-19	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-8k6vsvc	Manual Techniques for people with Hearing Difficulties	Recruitment completed	Intervention	2025-08-15	<NULL>	<NULL>	8211	Osteopathic Manipulative Treatment in patients with Hearing Loss in a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-19	Escola de Osteopatia de Madrid - Brasil Ltda.	Universidade Tuiuti do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8k6vsvc	<NULL>	Patients of both sexes; between 60 and 75 years old; with a clinical diagnosis of bilateral sensorineural hearing loss; who must first submit the Free and Informed Consent Form (FICF)	Patients after ear surgery and those who continuously use high-risk ototoxic medications, such as chemotherapy (cisplatin subclass) and cardiovascular drugs (diuretic subclass) or drugs in the 72 hours prior to the exam, as they may alter auditory physiological conditions; patients with malignant necrotizing external otitis and benign and malignant tumor pathologies of the ear; with fistulas and/or auricular cysts; patients with cerumen plug; patients with complaints of tinnitus; patients who are undergoing previous osteopathic treatment or who have a diagnosis or suspicion of any acute or chronic condition that limits their ability to participate in the study; those who have consumed stimulant beverages in the 24 hours prior to the evaluation; those with acute pain in the last 72 hours; who have consumed alcohol in the last 48 hours; and those who have not performed acoustic rest for 14 hours prior to the audiometry exams	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-8spzvbj	Effects of brain stimulation and video games on cognitive and motor function in older adults with mild cognitive impairment	Recruiting	Intervention	2025-08-14	<NULL>	<NULL>	8208	Acceptability, safety and efficacy of non-invasive brain stimulation on cognitive and motor functioning in older adult patients with mild neurocognitive impairment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-12	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8spzvbj	<NULL>	Present with mild impairment cognitive; both sexes (female and male); absence of dementia based on a score on the Clinical Dementia Rating scale equal or less 0,5 according to Hughes et al 1982; age between 50 and 75 years; signs of cognitive decline according to the Montreal Cognitive Assessment cutoff points, adjusted for age and education by Apolinario et al 2018; no or minimal functional impairment due to cognition according to the score on the Activities of Daily Living Questionnaire equal or less 0,33 according Medeiros and Guerra 2009; no unstable disease that prevents planned exercise, as well as absence of known organic or psychiatric condition that compromises cognition; normal or corrected visual and auditory acuity; ability to walk independently; report a minimum schooling age of four years so that there is no impairment in performance in cognitive assessment instruments due to the influence of educational level  according Apolinario et al 2018 and Avila et al 2009; have not previous experience with the Nintendo Switch video game; have not undergone physiotherapy treatment in the last 2 months before the start of the study; have no metal implants in the head	Participants will not be included in the study if they require high-level home care; have neurological disorders; have bone deformities that make it difficult to maintain a bipedal posture; have unstable cardiovascular diseases or other uncontrolled chronic conditions that interfere with the safety and conduct of training; have a history of severe alcohol and drug abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-5ykqbcn	Patient satisfaction during Home Whitening using clear aligners: a Blinded Randomized Equivalence Clinical Trial	Recruitment completed	Intervention	2025-08-13	<NULL>	<NULL>	8205	Patient satisfaction during Home Whitening using clear aligners: a Blinded Randomized Equivalence Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Andres Felipe felipe Millan Cardenas	Universidade CEUMA	https://ensaiosclinicos.gov.br/rg/RBR-5ykqbcn	<NULL>	Volunteers of both genders; aged 18 years or older; in good general and oral health; with orthodontic needs or current users of orthodontic aligners; teeth free of carious lesions; no gingival recession or periodontal disease in the anterior region; willing to sign the informed consent form (ICF); tooth color of A2 or darker according to the Vita Classical shade guide on the canines.	Individuals who have previously undergone tooth whitening procedures; history of dental sensitivity; presence of deciduous teeth; use of dental prostheses; restorations on anterior maxillary teeth; previous endodontic treatment on anterior maxillary teeth; presence of gingival recessions; teeth with discoloration due to tetracycline or fluorosis; visible cracks in anterior teeth; continuous use of medications such as analgesics and/or anti-inflammatory drugs; pregnant or breastfeeding women; individuals with parafunctional habits such as bruxism; current smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-2w3p7z7	Clinical evaluation of an adhesive containing stabilizate silane in non-carious lesions	Recruitment completed	Intervention	2025-08-13	<NULL>	<NULL>	8206	Clinical Evaluation of an Universal Adhesive containing Stabilizate Silane in Non-Carious Cervical Lesions: Randomized Clinical Trial, triple-blind.	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2025-04-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2w3p7z7	<NULL>	The inclusion criteria considered patients classified as ASA I or II, aged between 18 and 65 years, who presented good oral hygiene and at least 20 teeth in occlusion. Furthermore, participants should present at least two non-carious cervical lesions (NCCLs) with a depth greater than 1mm.	The exclusion criteria are: individuals with periodontal disease, characterized by probing depth greater than 3 mm, gingival bleeding, or dental mobility of grade II or higher. Also excluded were individuals with parafunctional habits, smokers, orthodontic appliance wearers, teeth serving as prosthetic abutments, and pregnant women. Finally, individuals who did not agree with the research terms or who presented difficulties in attending the necessary follow-ups after the restorations were performed were also excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-10whktxm	Menopause in female night workers	Recruitment completed	Intervention	2025-08-13	<NULL>	<NULL>	8207	Intervention with exogenous melatonin: reduction of effects of Climacteric Syndrome in night shift health workers at a hospital in São Paulo	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-08-01	Faculdade de Saúde Pública da Universidade de São Paulo	Hospital Alemão Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-10whktxm	<NULL>	Women; Age from 38 years old who are in the perimenopause period; Work for at least six months in the current work shift; Declare that they do not intend to change their eating habits, that is, they do not intend to adhere to calorie-restricted diets, food groups and/or meal times. Also declare that you do not intend to modify the physical activities, and these should be maintained during the study, not starting new ones, nor pausing those that are already carried out.	Women who undergo hormone replacement therapy; Pregnant women; Lactating; Mothers with children under 1 year old; Have a second night shift work; Abusive use of drugs and/or alcohol; Make regular use of medications or supplements that influence sleep, alertness and the circadian timing system.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-67jkxsj	Effect of Topical Melatonin Gel on the healing of post-extraction sites	Data analysis completed	Intervention	2025-08-12	<NULL>	<NULL>	8202	Evaluation of the effect of Melatonin Gel on post-extraction Dental Socket preservation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Comando da Aeronáutica	Programa de Pós Graducação em Odontologia da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-67jkxsj	<NULL>	Healthy volunteers over 18 years of age; of either gender; with an indication for the extraction of premolar or molar teeth from any dental arch who have adjacent teeth present; and are willing to cooperate with the study	Volunteers presenting with teeth affected by acute periapical or periodontal infections (abscesses); those with severe systemic diseases or under medications such as chemotherapy, anticoagulants, corticosteroids, antiresorptive drugs, or immunosuppressive agents; patients using systemic melatonin; individuals with decompensated chronic diseases; metabolic bone disorders; any motor dysfunction that impairs or prevents proper oral hygiene; smokers (former smokers must have ceased smoking for at least 6 months); pregnant women; and patients who have undergone radiotherapy within the past 5 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-537bzqt	Comparison between the use of Connective Tissue Graft and Platelet Rich Fibrin treated with Ozone in the treatment of Cairo type I Gum Recession: a randomized controlled trial	Terminated	Intervention	2025-08-12	<NULL>	<NULL>	8203	Comparative Analysis Between the Use of Connective Tissue Graft and the Use of Ozonized Platelet-Rich Fibrin for the Treatment of Cairo Type I Gingival Recessions: Randomized Controlled Clinical Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-537bzqt	<NULL>	Patients who present Cairo RT1 gingival recession; the teeth must be healthy, with all sites presenting a probing depth less than or equal to 3 mm; bleeding rate less than or equal to 5%; without gingival inflammation; free of caries; both sexes	Patients with a history of systemic disease; drug use; pregnant or lactating women; presence of pathogenic occlusal interference; carious lesions; previous surgeries at the site of the recession	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-2j24fkk	Effectiveness of Arginine supplementation in aiding the treatment of Sickle Cell Anemia	Not yet recruiting	Intervention	2025-08-12	<NULL>	<NULL>	8204	Randomized double-blind placebo controlled clinical trial to study the efficacy of L-arginine: adjuvant therapeutic protocol in the treatment of Sickle Cell Anemia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2026-06-01	Secretaria da Saude do Estado do Ceara	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2j24fkk	<NULL>	Adult patients with Sickle Cell Anemia; age 18 or over; of both sexes; taking hydroxyurea (dose equal to or greater than 500mg/day)	Patients who have undergone transfusion therapy in the last three months; patients using iron chelators or antioxidant vitamins; smokers; alcoholics; pregnant women; with Diabetes mellitus; renal and/or hepatic insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-8s839dj	Selfcervix: Self-collection strategy for cervical Cancer screening	Data analysis completed	Intervention	2025-08-11	<NULL>	<NULL>	8201	Analysis of alternative methods for cervical Cancer screening	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2016-06-24	Hospital Universitário da Universidade de São Paulo	Ziel Biosciences Pesquisa, Desenvolvimento e Diagnóstico LTDA	https://ensaiosclinicos.gov.br/rg/RBR-8s839dj	<NULL>	Women between 25 and 65 years old referred for colposcopy due to Pap smear with suspicious changes of neoplastic cervical lesions and/or positive HPV (Human Pappiloma Virus) PCR (Polymerase Chain Reaction).  All must agree to participate and sign the Free and Informed Consent Form in advance.	"Pregnant women; immunocompromised women; women who have not yet started
sexual activity; or those who have already undergone chemotherapy or
radiotherapy"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-9cnvv46	Effects of Virtual Reality on children and young people with sensory and motor problems	Not yet recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8194	Effects of an intervention protocol using Virtual Reality in children and young people with sensory-motor changes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	https://ensaiosclinicos.gov.br/rg/RBR-9cnvv46	<NULL>	Children and young people with sensorimotor disorders; will be included in the study; of both sexes; aged from 10 years to 17 years 11 months and 29 days	Participants unable to understand will be excluded; execute intervention-specific instructions and commands	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-10k58ztj	Effect of acid conditioning in the treatment of periodontal bone defects	Recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8195	Effect of superficial bone demineralization by citric acid and tetracycline on the repair of infra-bone defects. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade de São Paulo, Faculdade de Odontologia de Bauru	Universidade de São Paulo, Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-10k58ztj	<NULL>	Age 35 - 60 years; radiographic evidence of at least one infrabony 2 or 3-wall or combined interproximal periodontal defect; attachment loss ≥ 5 mm	Systemic disorders (uncontrolled diabetes and hypertension, hemophilia or other coagulation disordes); pregnants or lactants; systemic therapy with antimicrobials, antineoplastics, anticoagulants, immunostimulants or immunodepressors 4 weeks before study beggining; radiotherapy and/or immunosupression; endodontic lesions; grade 2 tooth mobility; severe parafunction; allergy to citric acid and/or tetracycline; illicit drugs or alcohol abusers; smokers or former smokers &lt; 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-6735k46	Effect of functional training on postural control and gait in older adults during associated tasks	Not yet recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8196	Effect of 12 weeks of functional training on postural control and locomotor pattern in dual task stair ascent and descent in older adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-6735k46	<NULL>	Healthy elderly; men and women; age between 60 and 80 years; preserved cognitive function; independent walking;	Neurological conditions that prevent the performance of experimental tasks; musculoskeletal conditions that prevent the performance of experimental tasks; vestibular conditions that prevent them from performing experimental tasks; health conditions that significantly compromise balance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-54jvjfk	Use of Percutaneous Ultrasound-Guided Microwave for uterine fibroids treatment	Recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8197	Phase I Clinical Study of Safety and Tolerability of Percutaneous Ultrasound-Guided Microwave for Thermal Ablation of Uterine Myomas. MiWaMA Project (MicroWave Myoma Ablation)	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2024-12-11	Fundação do ABC	Fundação do ABC	https://ensaiosclinicos.gov.br/rg/RBR-54jvjfk	<NULL>	Women; 18 of more years old; clinical diagnosis of uterine fibroids from type 2 to type 6, including classification of International Federation of Gynecology and Obstetrics 2-5; with a uterine volume above 50 mL; who report that they will not attempt pregnancy in the next 24 months at the beginning of the study; who have not undergone changes in their clinical conditions through conservative treatments or therapies; without signs of perimenopause; who have a safe transabdominal puncture course available; who report a desire to preserve the uterus; and who have voluntarily accepted microwave ablation treatment, by signing the informed consent form	Women who express a desire to stop participating in the study during the course of treatment; who become pregnant after the procedure; or who have clinically significant adenomyosis; women who have any malignancy in the genital organs,endometriosis requiring surgical treatment; other systemic diseases such as liver, kidney, or heart disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-3vjv574	Evaluation of the effectiveness of using cosmetics for skin care in cancer patients	Not yet recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8198	Evaluation of the use of cosmetics for skin care in cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de São João del-Rei	Hospital São João de Deus Fundação Geraldo Corrêa	https://ensaiosclinicos.gov.br/rg/RBR-3vjv574	<NULL>	Women; aged between 18 and 59 years; taking oral capecitabine (Xeloda®); who agree to participate in the study after reading the Informed Consent Form (FICF); who present a medical referral for participation in the proposed protocol; who do not report previous allergic reactions to cosmetics; who present mental conditions suitable for participation in the study, as assessed using the Mini Mental Scale	Patients diagnosed with breast cancer who do not use oral capecitabine (Xeloda®); Clinical condition that makes it unsafe to participate in a group setting (e.g., severe neutropenia); Report allergy to the use of cosmetics; Patients who use capecitabine (Xeloda®) concomitantly with radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-977kxd5	Vaginal bleeding patterns and satisfaction with contraceptive implant use in trans men on testosterone therapy:clinical study	Recruiting	Intervention	2025-08-10	<NULL>	<NULL>	8199	Vaginal Bleeding Pattern and Satisfaction with the Use of the Etonogestrel Implant in transgender Men on Testosterone therapy	<NULL>	4, single-arm-study, n/a	4	<NULL>	<NULL>	<NULL>	2024-12-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-977kxd5	<NULL>	Transgender men; aged between 18 and 45 years; undergoing testosterone therapy; requiring contraception and/or wishing to reduce menstrual flow and/or dysmenorrhea	Participants with deep vein thrombosis; active thromboembolism; active severe liver disease; history of hepatic tumors; unexplained abnormal vaginal bleeding; current diagnosis of breast cancer; past diagnosis of breast cancer;  suspected hormone-dependent neoplasia; known allergy  to etonogestrel  allergy to any component of Implanon®; participants who are unable to attend follow-up visits for a period of 1 year	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-7jhxrv9	Influence of age on reported sensitivity after bleaching treatment	Data analysis completed	Intervention	2025-08-08	<NULL>	<NULL>	8191	Influence of age on sensitivity to dental clarification of consulting: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-03	Universidade Federal do Amazonas	Faculdade de Odontologia - Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-7jhxrv9	<NULL>	Volunteers between 14 and 18 years old and between 31 and 50 years old; of both genders; dissatisfied with the color of their teeth; no systemic diseases (metabolic, heart and immunological diseases); oral condition without periodontal disease; selected after publication on posters and guidelines within the scope of the Dentistry faculty clinic; at least two central incisors or canines with color A2 or darker; the six upper front teeth free of restorations on the palatal and buccal surfaces; healthy enamel and without pathological, physiological and medicinal changes	Use of orthodontic braces; severe crowding; presence of intrinsic stains (tetracycline staining, fluorosis, pulped teeth); using anti-inflammatory drugs and antioxidant analgesics, which may mask sensitivity; smokers; alcoholics; pregnant or breastfeeding women; participants who have already undergone a whitening procedure; participants with bruxism, or significant oral pathologies; participants with exposed dentin in the incisal portion of the anterior teeth; with non-carious cervical lesions; patients who reported previous sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-8v5z7r2	Acute effects of manual therapy on pain and functional performance in jiu-jitsu practitioners with Patellofemoral Pain Syndrome: a randomized, triple-blind crossover clinical trial	Recruiting	Intervention	2025-08-08	<NULL>	<NULL>	8192	Acute effects of Instrument-Assisted Soft Tissue Mobilization and Joint Mobilization on pain and functional performance in jiu-jitsu practitioners with Patellofemoral Pain Syndrome: a randomized, triple-blind crossover clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-31	Universidade do Estado do Pará - Centro de Ciências Biológicas e da Saúde - Campus II	Universidade do Estado do Pará - Centro de Ciências Biológicas e da Saúde - Campus II	https://ensaiosclinicos.gov.br/rg/RBR-8v5z7r2	<NULL>	Jiu-jitsu practitioners; of both sexes; aged between 18 and 45 years; with a minimum of 2 years of continuous practice of the modality on a regular basis; who present with recurrent anterior knee pain in the last 4 weeks, of atraumatic origin; present pain in two or more situations, including running, jumping, squatting, kneeling, climbing and descending stairs, resisted knee extension and patellar palpation; agree to participate in the research voluntarily through the Consent Form	People who do not practice the sport regularly; who present any clinical condition that is a contraindication to performing physical exercise and the techniques applied; history or suspicion of tendinopathies, dislocations and other knee injuries; who have undergone surgical procedures; who are undergoing other therapeutic interventions, use of ergogenic resources during the data collection period or use continuous medication; who are pregnant; and anyone who does not accept to participate in the research voluntarily through the Free and Informed Consent Form will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-4njwqsw	Efficacy of a New Device to prevent Cervical Narrowing after Conization	Not yet recruiting	Intervention	2025-08-08	<NULL>	<NULL>	8193	Efficacy of an Intracervical Device (ICD) in preventing Cervical Stenosis following Type III Excisional Procedure (Conization) of the uterine cervix	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2025-09-01	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4njwqsw	<NULL>	Women indicated for type III excision (conization) of the uterine cervix; women aged 25 and older	Women with any history of previous excisional procedures (regardless of type or timing); pregnant women; women who become pregnant within 90 days following the excisional procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-53phztq	How judo can help in the mental development of schoolchildren	Recruitment completed	Intervention	2025-08-08	<NULL>	<NULL>	8280	The impact of judo practice on the development of executive functions in schoolchildren	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Federal do Maranhão (UFMA)	Universidade Federal do Maranhão (UFMA)	https://ensaiosclinicos.gov.br/rg/RBR-53phztq	<NULL>	Students regularly enrolled in the early years of elementary school at an educational institution in São Luís; aged between 7 and 13 years; of both sexes; with regular attendance in classes; parental or guardian consent to participate in the research, confirmed by signing the Informed Consent Form; availability to take part in both the initial and final assessments of executive functions; not having engaged in any regular physical activity in the past 3 months	Medical or health conditions that may interfere with the safe participation in judo activities or the completion of cognitive tests; prior participation in regular judo classes or other forms of martial arts outside of school within the past six months; children diagnosed with the following conditions will be excluded from the sample: learning disorders, attention-deficit/hyperactivity disorder (ADHD); intellectual disabilities; or hearing or visual impairments; any other condition that, at the researcher’s discretion, could compromise data integrity or participant safety; youngers choolchildren than 7 or older than 13 years of age; children who have previously practiced judo at any point in their lives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:12
RBR-7v3rgrt	Evaluation of the Sede-E protocol in practice: clinical study conducted in multiple hospitals with randomized participants	Not yet recruiting	Intervention	2025-08-07	<NULL>	<NULL>	8190	Clinical evaluation of the use of the Sede-E protocol: multicenter randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-01	Universidade Estadual de Londrina	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-7v3rgrt	<NULL>	Patients admitted to the Intensive Care Unit (ICU); within one hour of extubation; not using non-invasive ventilation at the time of assessment; age 18 or older; both sexes; thirsty	Need for reintubation; post-operative head and neck surgery; dysphagia prior to intubation; and contraindication to elevating the head of the bed by 30 to 45º	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-2ch5z38	Effect of reading an e-book by dentistry students to gain knowledge about early loss of anterior deciduous teeth and creation of a support and guidance tool for parents about dental trauma to baby teeth	Data analysis completed	Intervention	2025-08-05	<NULL>	<NULL>	8183	The use of a book in digital format by undergraduate students to acquire knowledge about the early loss of deciduous anterior teeth	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-11	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro UFRJ	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-2ch5z38	<NULL>	Students over 18 years of age; regularly enrolled in any period of the Undergraduate Dentistry course at the Federal University of Rio de Janeiro (UFRJ) in the second semester of 2023; both genders	Students under 18 years of age; who are not enrolled in any period of the Undergraduate Dentistry course at the Federal University of Rio de Janeiro (UFRJ) in the second semester of 2023	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-86n2z67	Assessment of brain development in preterm infants who received Maternal Colostrum at birth	Recruiting	Observational	2025-08-05	<NULL>	<NULL>	8184	Assessment of Developmental in preterm infants exposed to Oropharyngeal Colostrum Immunotherapy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-05	Universidade Estadual de Feira de Santana (UEFS/BAHIA)	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-86n2z67	<NULL>	Preterm newborns; with gestational age less than 37 weeks; weight below 1,500 grams; for the exposure group, only those on zero, enteral, or parenteral feeding; and clinically stable in the past three hours	Newborns whose mothers have a diagnosis of psychological disorders; triplet or higher-order multiple pregnancies; newborns with syndromes or congenital malformations; mothers with contraindications to breastfeeding; as well as newborns receiving vasopressor medication at doses higher than 10 mcg·kg⁻¹·min⁻¹ or requiring immediate surgical intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-9pzj4vz	Breast diagnostic study by Magnetic Spectroresonance	Data analysis completed	Observational	2025-08-05	<NULL>	<NULL>	8185	Accuracy assessment of Breast Spectroscopy by Magnetic Resonance	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-09-20	Hospital da Clínicas da Universidade Federal de Goiás	Centro Avançado de Diagnóstico da Mama (CORA)	https://ensaiosclinicos.gov.br/rg/RBR-9pzj4vz	<NULL>	Women over 18; who agreed to participate in the study and signed the Free and Informed Consent Form; Health Unique System (SUS) users as BI-RADS 4 and 5 with breast anomaly or diagnosed by mammography and/or ultrasound and who have already received a recent diagnosis of breast cancer and who will be referred for incisional, excisional or reexcisional biopsy	Patients who present a high level of claustrophobia as we understand that the patient&apos;s non-cooperation could compromise the exam; pacemaker; surgical clips for aneurysms; bearers of neurostimulators; pregnant patients; and patients suffering from gunshot wounds with a projectile lodged and not removed; in addition to a previous history of reaction to gadolinium; women who were not the minimum age required for the study; did not agree to participate in the study or refused to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-6s4f6zv	How pupil biofeedback can help motor learning in children and adolescents with Autism Spectrum Disorder	Recruiting	Intervention	2025-08-05	<NULL>	<NULL>	8186	Biofeedback of Pupil Dilation in motor learning of children and adolescents with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6s4f6zv	<NULL>	Present adequate cognitive and motor skills to perform the experimental tasks; not have an intellectual disability or physical disability that prevents the performance of the motor task; absence of comorbidities that may interfere with the results according to the medical diagnosis presented at the time of entry into the projects; 6 to 17 years old; both sexes	Inability to follow instructions to perform the task either due to lack of motivation or understanding of the task; children and adolescents with autism spectrum disorder with level 2 and 3 severity (severe) according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders in its 5th edition and medical report; refusal of the participant or their guardian to perform the experiment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-858cd68	Efficacy of Bromelain in controlling pain, edema and trismus after third molar extractions	Data analysis completed	Intervention	2025-08-05	<NULL>	<NULL>	8188	Comparative analysis of the effectiveness of Bromelain versus Ibuprofen in the control of pain, edema and trismus after toohth extractions	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2023-09-15	Universidade de Pernambuco - Multicampi Garanhuns	Universidade de Pernambuco - Reitoria	https://ensaiosclinicos.gov.br/rg/RBR-858cd68	<NULL>	Indication of complicated extractions or bilateral lower third molars; teeth indicated for extraction must present the same degree of difficulty for removal; participants of both sexes; participants must be between 18 and 35 years old; healthy participants (ASA I) and with controlled systemic diseases (ASA II); absence of infectious process at the surgical site; not having used antimicrobials, anti-inflammatories or analgesics in the last two weeks	Participants allergic to nonsteroidal anti-inflammatory drugs, bromelain derivatives, and dipyrone; patients with missing upper and lower incisors or prostheses due to the impossibility of measuring mouth opening; patients with a history of blood dyscrasias or chronic pain; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-7jsmd3j	Study of efficacy and safety of a new Reusable Device used in Adrenal Gland Videosurgery	Data analysis completed	Intervention	2025-08-01	<NULL>	<NULL>	8179	Clinical validation of a new Reusable Balloon Trocar for dissection in Retroperitoneoscopic Adrenalectomy	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2020-11-26	Hospital Nossa Senhora da Conceição	Hospital Militar de Área de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7jsmd3j	<NULL>	Patients aged 18 or over; male and female; with adrenal tumors with indication for surgical removal after functional and imaging analysis; treated at the Clinical and Surgical Endocrinology outpatient clinic of Hospital Nossa Senhora da Conceição in Porto Alegre; and discussed in a monthly multidisciplinary Tumor Board meeting	Patients with a Body Mass Index (BMI) greater than 35; patients with a history of pyelonephritis ipsilateral to the adrenal tumor; tumors larger than 6 cm; tumors smaller than 4 cm and non-hypersecretory; tumors with invasion of adjacent structures (vena cava, kidney, duodenum) suggestive of adrenal carcinoma on imaging (Computed Tomography); patients with previous retroperitoneal surgery ipsilateral to the adrenal tumor or history of trauma; patients with contraindications or high risk for general anesthesia; malfunction of the Sonicision ultrasonic coagulator forceps in which it cannot be replaced or is not available	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-10kxvwb2	The effect of technologies that care and educate on the resilience of adolescent students at social risk	Not yet recruiting	Intervention	2025-08-01	<NULL>	<NULL>	8180	Effect of Care-Educational Technologies on the Resilience of School Adolescents in Situations of Social Vulnerability: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-20	Departamento de Enfermagem da Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10kxvwb2	<NULL>	Participants of both sexes; aged between 16 and 19 years; belonging to state schools located in communities with high levels of social vulnerability and/or low Basic Education Development Index; belonging to the Recife Sul Regional School Management	Participants with a previous medical diagnosis of special educational needs presented to the school administration that may compromise their participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-3wqx6b6	Non-invasive brain stimulation for the treatment of symptoms of Anxiety and Depression in patients with Endometriosis	Not yet recruiting	Intervention	2025-08-01	<NULL>	<NULL>	8181	Transcranial Direct Current Stimulation for the treatment of Anxiety and depressive symptoms in individuals with Endometriosis: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-30	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3wqx6b6	<NULL>	Women; age between 18 and 40 years; diagnosis of Endometriosis identified by imaging exams and the presence of clinical findings; cognitive ability to understand and answer questionnaires; tolerance to treatment with electrical stimulation; symptoms of Anxiety identified by the Hamilton Anxiety Scale; depressive symptoms identified above 16 on the Center for Epidemiological Studies – Depression Scale	Being in the puerperal period (up to 12 months postpartum); currently breastfeeding; history of brain surgery, tumors, dizziness, or epileptic disease; history of alcohol or drug abuse; having metallic implants in the head; complaint of severe headache, dizziness, or severe migraine within 6 hours after the application in more than two sessions of Transcranial Direct Current Stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-5hjstkg	Evaluation of ealing following mandibular third molar Extraction using a Modified Suture Technique	Other	Intervention	2025-08-01	<NULL>	<NULL>	8182	Evaluation of morbidity, healing, and periodontal parameters in the Extraction of erupted mandibular third molars using a Modified Flap Suture Technique	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5hjstkg	<NULL>	Inclusion criteria for the sample of this study will be: Volunteers of both genders aged between 18 and 35 years old; Presence of both erupted lower third molars with indication for surgical removal; No use of medications that influence bone or soft tissue regeneration; Presence of erupted and healthy second molars; No active odontogenic infection episodes; Individuals who agree to sign the Informed Consent Form (ICF); No previously diagnosed Temporomandibular Disorders (TMD); No neuropathic facial pain; No allergic reaction to any of the medicinal or pharmacological compounds used in the pre or postoperative protocol	Exclusion criteria were as follows: Failure to attend postoperative follow-up appointments; Occurrence of flap lacerations during surgery; Fracture of the second molar crown during third molar extraction; Exceeding 40 minutes between incision and suturing; Significant discrepancy in duration between the first and second surgeries; Withdrawal of consent at any time; Participants with special needs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-329hg56	Improving communication in nurses: randomized clinical trial	Recruitment completed	Intervention	2025-07-31	<NULL>	<NULL>	8172	Efficacy of a program to improve communication in nurses: randomized clinical trial	<NULL>	1, randomized-controlled, n/a	1	<NULL>	<NULL>	<NULL>	2024-12-05	Hospital das Clínicas da Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-329hg56	<NULL>	Be a nurse; provide direct patient care; work for at least three months in the institution; not have a temporary contract; not have previously completed a communication training program; be at least 18 years old; both sexes	Nurses who did not attend two intervention meetings; or who did not respond to the instruments, in the last stage of this phase of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-4msv7mh	Effect of Laser therapy on pain in lactating postpartum women with nipple Fissures	Not yet recruiting	Intervention	2025-07-31	<NULL>	<NULL>	8173	Effectiveness of a protocol using Photobiomodulation therapy on pain in lactating postpartum women with nipple Fissures: a randomized, controlled, double-blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Alfenas UNIFAL-MG	Universidade Federal de Alfenas UNIFAL-MG	https://ensaiosclinicos.gov.br/rg/RBR-4msv7mh	<NULL>	Postpartum women over 18 years of age; with nipple fissure secondary to breastfeeding; with pain graded at least two by the NDT; with the ability to understand and answer questions	Women who refused to undergo the intervention; those using other substances on the nipple, such as ointments; presence of a systemic or local infectious process; presence of underlying diseases that make therapy difficult or impossible, such as diabetes mellitus; cancer; neurological diseases; cognitive alterations; pregnancy and photosensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-27dmxjc	How using a positive pressure device affects Blood Pressure tiredness and quality of life in people with Sleep Apnea	Recruiting	Observational	2025-07-31	<NULL>	<NULL>	8174	Impact of Desaturation Index during Positive Pressure Device Therapy on blood pressure, excessive daytime impairment and quality of life in patients with Obstructive Sleep Apnea	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Departamento de Oftalmologia e Otorrinolaringologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital Paranaense de Otorrinolaringologia	https://ensaiosclinicos.gov.br/rg/RBR-27dmxjc	<NULL>	Patients of both sexes; aged 18 years or older; diagnosed with systemic arterial hypertension (SAH) for at least 6 months; with severe obstructive sleep apnea syndrome (OSAS); with a baseline apnea-hypopnea index (AHI) greater than 30 events per hour; with indication to start therapy with continuous positive airway pressure (CPAP) at Hospital IPO after clinical evaluation in the researcher&apos;s medical office. Last patient to be recruited on October 1, 2025	Patients younger than 18 years of age; baseline examination showing predominantly central sleep apnea; history of drug or alcohol abuse; presence of comorbidities such as congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), cerebrovascular disease or neuromuscular disorders; current smoking or smoking cessation less than 10 years ago; use of opioids or benzodiazepines; refusal to participate in any stage of the study; night work or shift work; previous use of any specific therapy for obstructive sleep apnea syndrome (OSAS) between the baseline polysomnography and the initial consultation with the researcher, including the use of continuous positive airway pressure (CPAP)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-3vh596c	Optical behavior of monochromatic composite resins in non-carious lesions before and after dental bleaching	Recruiting	Intervention	2025-07-31	<NULL>	<NULL>	8175	Optical behavior of single-shade resin-based composite in non-carious cervical lesions before and after dental bleaching: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3vh596c	<NULL>	Good general health status; minimum age of 18 years; female or male gender; acceptable levels of oral hygiene; presence of at least 20 teeth in occlusion; presence of at least three primary non-carious cervical lesions in premolars with similar size, shape, and dimensions	Patients with poor oral hygiene; users of orthodontic appliances; severe or chronic cases of periodontitis; cases of severe bruxism; patients with allergies to any material to be used in the research, pregnant; breastfeeding women;  patients who have undergone previous whitening; the presence of previously restored non-carious cervical lesions; clinical and radiographic signs of pulpal involvement of the lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-3w99cg6	Non-Invasive Ventilation in the emergency room: understand how the procedure can fail and what changes occur in the patient&apos;s body	Recruitment completed	Intervention	2025-07-31	<NULL>	<NULL>	8176	Non-Invasive Ventilation as rescue therapy in the emergency setting: evaluation of short-term failure predictors and physiological changes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Escola Superior de Educação Física da Universidade Federal de Pelotas	Faculdade de Medicina da Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-3w99cg6	<NULL>	Patients of both sexes, aged 18 years or older with no upper age limit; admitted to the Emergency Department of the Pelotas Emergency Hospital due to Acute Respiratory Failure secondary to Chronic Obstructive Pulmonary Disease or cardiogenic Acute Pulmonary Edema; between January 2024 and August 2024; who were eligible for noninvasive ventilation	Acute Respiratory Failure from causes other than Acute Pulmonary Edema and Chronic Obstructive Pulmonary Disease; Contraindication to Non-Invasive Ventilation, such as Refractory Hypoxemia; Glasgow Coma Scale score below 8; Agitation; Patient Refusal; Hemodynamic Instability with Systolic Blood Pressure below 90 millimeters of mercury; Complex Arrhythmias; Acute Myocardial Infarction; Upper Airway Obstruction; Facial Trauma; Ineffective Cough; Inability to Swallow; Intractable Vomiting; Significant Abdominal Distension; Upper Gastrointestinal Bleeding; Undrained Pneumothorax; Post-operative Status after Surgery of the Upper Airway; Esophagus, or Face; Severe Respiratory Acidosis requiring Immediate Intubatio	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-95jnbpt	Efficacy of In-office Bleaching immediately and 72 hours after its manipulation	Not yet recruiting	Intervention	2025-07-31	<NULL>	<NULL>	8177	Efficacy of In-office Bleaching with Attachable Syringe: immediate and after 72 hours of mixing: randomized, triple-blind equivalence clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-95jnbpt	<NULL>	Volunteers aged at least 18 years; both sexes; with good general and oral health; with teeth free of caries and periodontal disease in the anterior region; who agree to the free and informed consent form and whose canines must have A2 color or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany)	Volunteers who have previously undergone a whitening procedure; who have reported the presence of previous dental sensitivity; presence of dental prosthesis; fixed orthodontic appliance; restorations in the upper anterior teeth; endodontic treatment in the upper anterior teeth; gingival recessions; teeth with tetracycline staining or fluorosis; continuous use of medications such as analgesics and anti-inflammatories; pregnant or lactating women and those with habits such as bruxism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-3mcfsb9	Influence of Anti-inflammatory Drug use during Glaucoma tube implant surgery	Terminated	Intervention	2025-07-31	<NULL>	<NULL>	8178	Influence of Subtenon Triamcinolone as an adjunct in the hypertensive phase of Susanna&apos;s Drainage Device in the postoperative period	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2020-12-08	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3mcfsb9	<NULL>	Age 18 years or older; both genders; diagnosis of primary open-angle glaucoma refractory to maximally tolerated medical therapy and failure of at least one previous trabeculectomy surgery; indication for primary implantation of the Susanna UF glaucoma drainage device; best-corrected visual acuity in the study eye of light perception or better; ability to understand and sign the Informed Consent Form; availability to attend all study follow-up visits for a six-month period	No light perception visual acuity in the study eye; previous glaucoma drainage device surgery in the study eye; need for combined surgery at the time of Susanna UF drainage device implantation (e.g., phacoemulsification, pars plana vitrectomy); neovascular glaucoma; uveitic glaucoma; glaucoma following corneal transplantation; any ocular or systemic condition that, in the investigator&apos;s opinion, could prevent protocol-required examinations, interfere with outcome assessment, or significantly increase risk to the participant; concurrent participation in another interventional clinical trial	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-9qzb5r6	Impact of a Modality of Integrative and Complementary Health Practices in Primary Care: results from a mixed-methods study	Data analysis completed	Intervention	2025-07-30	<NULL>	<NULL>	8166	Assessment of a modality of Integrative and Complementary Health Practices in Primary Health Care: a mixed-methods study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Faculdade de Saúde Pública da USP	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9qzb5r6	<NULL>	Age 18 years or older; of both sexes; complaint of musculoskeletal pain symptoms in any part of the body for more than 3 months	Age below 18 years; with no musculoskeletal pain for more than 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-2qv38rt	Effectiveness of Speech Therapy in the self-assessment of patients with Refractory Chronic Cough	Recruitment completed	Intervention	2025-07-30	<NULL>	<NULL>	8167	Effectiveness of Speech-language Pathology Rehabilitation in the self-assessment of patients with Refractory Chronic Cough	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2qv38rt	<NULL>	Individuals of both sexes; over 18 years of age; with a complaint of Refractory Chronic Cough for more than six months associated with underlying comorbidities who were in treatment for at least two months; using medications such as antibiotics, inhaled bronchodilators, inhaled steroids, oral corticosteroids, proton pump inhibitors, antihistamines; neuromodulators such as Morphine, Gabapentin and Pregabalin	Individuals with untreated comorbidities associated with Chronic Cough; those taking angiotensin-converting enzyme inhibitor medications; untreated infections in the last two months; individuals with lung conditions, such as lung cancer, lung metastases, previously diagnosed endobronchial lesions, and lesions resulting from thoracic radiotherapy; limiting neurological diseases; and smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-7pjj8mk	Palliative Care for Lymphoma with early navigation and outcomes (PLENO study): a randomized controlled trial	Recruiting	Intervention	2025-07-30	<NULL>	<NULL>	8168	Early palliative care in patients with relapsed/refractory Non-Hodgkin Lmphoma	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Oncoclínicas Rio de Janeiro S.A	Oncoclínicas Rio de Janeiro S.A	https://ensaiosclinicos.gov.br/rg/RBR-7pjj8mk	<NULL>	Diffuse Large B-Cell Lymphoma (DLBCL); Primary Central Nervous System Lymphoma (PCNSL); HTLV-associated Lymphoma, Burkitt Lymphoma; Mantle Cell Lymphoma (MCL); Primary Mediastinal Large B-Cell Lymphoma (PMBCL); Peripheral T-Cell Lymphoma (PTCL);  transformed indolent Non-Hodgkin Lymphoma; both male or female; over 18 years old; followed in outpatient settings; capable of responding to the required information or accompanied by someone able to do so; who sign the informed consent form	Individuals under 18 years of age; patients who refuse to participate; patientse with a histopathological diagnosis of indolent Non-Hodgkin Lymphoma of the following subtypes: Follicular, Cutaneous T-Cell, and Lymphoplasmacytic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-6nr6hp5	Brain and Hormone Therapy after Menopause	Recruiting	Observational	2025-07-30	<NULL>	<NULL>	8169	Brain effects of Hypoestrogenism and Hormone Replacement in postmenopausal women: a prospective cohort study with multimodal Neuroimaging	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-10	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6nr6hp5	<NULL>	Hormonal therapy (HT) group: age between 45 and 55 years; absence of menstruation in the last six months and no more than 36 months; last spontaneous menstruation occurring after 40 years of age; plasma FSH levels greater than 40 IU/L and estradiol levels less than 25 pg/mL; clinical indication for HT; intention to administer HT for 16 or more uninterrupted weeks; have education greater than or equal to 7 years of formal study. N-HT group: women ineligible and/or who refused to receive hormone therapy: age between 45 and 55 years; absence of menstruation in the last six months and no more than 36 months; last spontaneous menstruation occurring after 40 years of age; plasma FSH levels greater than 40 IU/L and estradiol levels less than 25 pg/mL; have education greater than or equal to 7 years of formal study. Reference Group of pre-menopausal women: age between 35 and 40 years; have regular menstrual cycles; have education greater than or equal to 7 years of formal study	HT group: previous use of HT; use of antidepressants, anticonvulsants, benzodiazepines or other drugs with effects on the central nervous system; patients with major depressive disorder, anxiety disorder, bipolar affective disorder, schizophrenia or any other psychiatric disorder and neurological diseases with an impact on cognition; personal history of breast cancer; history of venous thromboembolism; history of stroke; established coronary disease; active liver disease; high-risk endometrial cancer; uterine bleeding of unknown cause. N-HT group: having undergone or currently undergoing non-hormonal pharmacological therapies for menopause; use of antidepressants, anticonvulsants, benzodiazepines or other drugs with effects on the central nervous system; women with major depressive disorder, anxiety disorder, bipolar affective disorder, schizophrenia or any other psychiatric disorder and neurological diseases with an impact on cognition; personal history of breast cancer; history of venous thromboembolism; history of stroke; established coronary disease; active liver disease; high-risk endometrial cancer; uterine bleeding of unknown cause. Reference Group of premenopausal women: irregular menstrual cycles; absence of menstruation in the last six months; having used or using contraceptive methods; use of antidepressants, anticonvulsants, benzodiazepines or other drugs with an effect on the central nervous system; women with major depressive disorder, anxiety disorder, bipolar affective disorder, schizophrenia or any other psychiatric disorder and neurological diseases with an impact on cognition; personal history of breast cancer; history of venous thromboembolism; history of stroke; established coronary disease; active liver disease; high-risk endometrial cancer; uterine bleeding of unknown cause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-10mcrfkq	Home monitoring of possible complications using the Meu PICC app in people with a central catheter inserted in the arm and treated in a day hospital	Data analysis completed	Intervention	2025-07-30	<NULL>	<NULL>	8170	Extra-hospital monitoring of complications by application Meu PICC in patients using peripherally inserted central catheter attended in a day hospital: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-27	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10mcrfkq	<NULL>	Age equal to or greater than 18 years; have a smartphone with camera and internet access with proficiency in its use; home use of peripherally inserted central catheter PICC for medication administration; follow-up at the day hospital of the referring institution; both genders	Referred or perceived psychiatric illness; reported or perceived cognitive or sensory impairment without caregiver; terminal illnesses (such as cancer with metastases); difficulty in communication; without a caregiver; patients without return to the day hospital	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-5kwy8yf	Saturation point for at-home bleaching	Recruiting	Intervention	2025-07-29	<NULL>	<NULL>	8160	Clinical assessment of the saturation point in teeth whitening	<NULL>	4, single-arm-study, single-blind	4	<NULL>	<NULL>	<NULL>	2025-05-15	Universidade Tuiuti do Paraná	Universidade Tuiuti do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5kwy8yf	<NULL>	Minimum age of 18 years; of both sexes; good general and oral health, without systemic diseases that may interfere with dental whitening; absence of periodontal disease, gingival recession or carious lesions in anterior teeth; upper canines with Whiteness Index for Dentistry (WID) shade less than 20 equivalent to A2 or darker, according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany); absence of restorations in anterior teeth, ensuring an accurate analysis of the color change; availability to attend consultations and follow the experimental protocol	Previous history of dental whitening; pre-existing dentin hypersensitivity, reported by the participant or identified during screening; continuous use of analgesic or anti-inflammatory medications, which may interfere with the perception of dental sensitivity; use of orthodontic appliances, dentures or restorations in anterior teeth, as they may influence the assessment of color; previous endodontic treatment in anterior teeth, which may affect the response to whitening; presence of severe tooth discoloration, including severe fluorosis, pulpless teeth or stains resulting from the use of tetracycline; visible cracks in tooth enamel, which may compromise the response to whitening; pregnancy or lactation, due to the lack of studies on the safety of whitening in this population; smoking or bruxism, which may influence color stability and oral health	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-2bzxr22	Use of Laser and Antimicrobial Dressing in the treatment of foot wounds in people with Diabetes	Not yet recruiting	Intervention	2025-07-29	<NULL>	<NULL>	8161	Photodynamic Therapy Alone, DACC, and their combination in the treatment of foot Ulcers in people with Diabetes: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-30	Hospital Universitário do Oeste do Paraná	Hospital Universitário do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2bzxr22	<NULL>	Individuals aged 18 years or older (men and women); who have 1 or more infected ulcers on the foot, present for at least 2 months and a maximum of 24 months, ulcer size from 1 to 100 cm2; who have an ankle-brachial pressure index greater than or equal to 0.80	Patients with known hypersensitivities or allergies to the dressing materials used in the study; patients undergoing recent or active cancer treatment; patients with severe malnutrition; patients with ulcers diagnosed as malignant; patients with systemic infection treated with continuous antibiotics (local and/or systemic antibiotics) for more than 5 consecutive days and in the last 5 days prior to treatment; patients who have used corticosteroids (local or systemic) in the 5 days prior to treatment; uncontrolled diabetes with glycated hemoglobin: Hb A1c greater than or equal to 10; chronic diseases that impair wound healing: autoimmune disorder in an acute flare-up phase, chronic kidney disease, and peripheral vascular insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-8kqhkz7	Assessment of Lavandula angustifolia Essential Oil in Temporomandibular Disorder: A Clinical Trial Investigating Therapeutic Effects	Recruiting	Intervention	2025-07-29	<NULL>	<NULL>	8162	Evaluation of the effect of Lavandula angustifolia Essential Oil as a treatment for Temporomandibular Disorder: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-05	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8kqhkz7	<NULL>	Both genders; alphabetized individuals; aged between nineteen and forty five; diagnosis of myalgia or myofascial pain with spread or reference; score of at least six on the subjective pain scale	Individuals with cognitive impairments that prevent them from answering the questionnaires; pregnant women; nursing mothers; people who are using analgesics within the 48 hours prior to the first assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-10yk36ht	Study to evaluate hydration in the prevention of blemishes after varicose vein treatment	Data analysis completed	Intervention	2025-07-29	<NULL>	<NULL>	8163	Prospective study of the impact of skin hydration on the incidence of post-sclerotherapy hyperpigmentation	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2024-02-10	Universidade Federal do Rio Grande	Irmandade Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10yk36ht	<NULL>	women. fitzpatrick III to IV. formal indication to sclerotherapy	Men. Patients &lt; 18 years old. patients with any contraindication to the sclerotherapy procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-5hq9fst	The effect of antibiotic therapy combined with Gingival Inflammation treatment in individuals with Diabetes	Recruiting	Intervention	2025-07-29	<NULL>	<NULL>	8164	Evaluation of the effectiveness of Antimicrobial Therapy with Amoxicillin and Metronidazole as an adjunct to Periodontal Treatment in individuals with type II Diabetes: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Federal De Minas Gerais	Universidade Federal De Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5hq9fst	<NULL>	Patients with type 2 diabetes mellitus and stage II or III periodontitis; patients without diabetes; aged 30 years or older; of both sexes; with a minimum of fourteen teeth; who agree to participate in the research by signing an informed consent form (ICF)	Individuals with diseases that affect the immune system; smokers; pregnant or breastfeeding women; individuals allergic to amoxicillin or metronidazole; individuals who have undergone periodontal treatment in the last 6 months; individuals who have received antimicrobial or anti-inflammatory therapy in the last 3 months; individuals who change their diabetes medication during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-56n2tb4	The impact of Oral Health guidance using Information and Communication Technology on the Quality of Life of individuals with Autism Spectrum Disorder	Terminated	Intervention	2025-07-29	<NULL>	<NULL>	8165	Effect of guidance measures on Oral Health using Information Technology and Communication in the Quality of Life of children and adolescents with Disabilities	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-10	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-56n2tb4	<NULL>	Children and adolescents diagnosed with Autism Spectrum Disorder - ASD; aged 6 to 14 years; of both sexes; who needed oral hygiene guidance and who had not attended dental services for at least three months before the start of the study	Children and adolescents who did not allow clinical examination; wore fixed orthodontic appliances; who had cleft lip and palate; they used medication with side effects in the oral cavity; whose caregivers were under eighteen years of age; those whose caregivers had performed this function for less than three months; or did not know how to read or write	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-10psthtk	Impact of Nutritional Intervention on the nutritional status of malnourished patients with gastrointestinal tract Cancer	Recruitment completed	Intervention	2025-07-25	<NULL>	<NULL>	8156	Impact of Nutritional Intervention on clinical outcomes in surgical patients	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-14	Liga Norte Riograndense Contra o Câncer	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-10psthtk	<NULL>	Patients of both sexes; minimum age of 20 years; with a confirmed diagnosis of cancer in the gastrointestinal tract and treated at the general surgery outpatient clinic	Hospitalization for less than 24 hours; patients on enteral and parenteral nutritional therapy; patients admitted to intensive care units; palliative care; pregnant women and/or individuals with infectious diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-8dyvkz7	Multimodal Preemptive Analgesia in third molar surgery, a randomized clinical trial	Not yet recruiting	Intervention	2025-07-25	<NULL>	<NULL>	8157	Evaluation of the efficacy of Multimodal Preemptive Analgesia with Nimesulide and Tramadol Hydrochloride versus Dexamethasone in controlling pain, edema and trismus after extraction of lower third molars	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri - UFVJM	https://ensaiosclinicos.gov.br/rg/RBR-8dyvkz7	<NULL>	Patients over 18 years of age; both sexes; without general health impairment according to medical history and physical examination; patients with indication for extraction of bilateral mandibular third molars; impacted; asymptomatic; in class IIB position, according to the Pell &amp; Gregory classification; with similar surgical difficulty	Patients with a history of hypersensitivity to any of the components of the medications used; patients who have used anti-inflammatory drugs in the 15 days prior to surgery; patients with tuberculosis, leukocytosis, collagen vascular diseases, multiple sclerosis, HIV infection, and other autoimmune diseases; pregnant and lactating patients; patients with a history of pericoronitis; patients with cognitive disorders that make it impossible to understand and execute commands; patients who withdraw consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-8d9fhcn	Spinal Manipulation vs. Mobilization: Which Is More Pleasurable? A Randomized Crossover Study	Not yet recruiting	Intervention	2025-07-25	<NULL>	<NULL>	8158	Is Spinal Manipulation more pleasurable than Mobilization? Randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-17	Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8d9fhcn	<NULL>	Healthy individuals of both sexes; aged 18 to 40 years; no significant low back pain in the past 3 months	Individuals with a history of recent trauma to the lumbar spine or other spinal regions; neurological impairment; osteoporosis; history of spinal surgery; history of spinal fractures; the presence of chronic or acute musculoskeletal injuries in the spine; use of corticosteroids in the past month and analgesics in the two days before the intervention; sensory alteration; having received spinal manipulation or mobilization in the five days preceding the interventions; pregnancy; history of autoimmune disease (ankylosing spondylitis, rheumatoid arthritis, or others); spinal inflammation; spinal tumor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-63frmt7	Use of the combination of Injectable platelet-rich fibrin with Plenum-oss® in maxillary sinus membrane elevation surgery	Recruitment completed	Intervention	2025-07-25	<NULL>	<NULL>	8159	Controlled, randomized, double-blind clinical study of the predictability of the association of i-PRF with Plenum-oss® in maxillary sinus membrane elevation surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-27	Universidade estadual Paulista Júlio de Mesquita Filho - Campus Araraquara	Faculdade de Odontologia da Universidade Estadual Paulista UNESP - Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-63frmt7	<NULL>	Adult patients aged at least 18 years; both sexes; healthy; with maxillary ridge atrophy with bone height less than 5 mm	Smoker; uncontrolled systemic diseases; blood dyscrasias; sinus pathologies; current or previous use of medications that interfere with bone turnover; irradiated in the head and neck region; pregnant women; untreated periodontal diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-29k8grc	Influence of Light Therapy on soft tissue healing after Tongue Tumor Removal	Recruiting	Intervention	2025-07-24	<NULL>	<NULL>	8152	Influence of Photobiomodulation with Low-power Laser Therapy on soft tissue healing after Glossectomy: a randomized, triple-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-20	Instituto do Câncer do Ceará	Instituto do Câncer do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-29k8grc	<NULL>	Patients over 18 years of age; of both genders; with head and neck cancer located on the tongue or floor of the mouth with an indication for partial or total glossectomy in stages I, II, III or IV	Patients who have undergone previous tumor resection surgery and/or neck dissection; patients with tumor recurrence or recurrence and with a previous history of radiotherapy in the head and neck region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-2hmgr4d	Analysis of gum substances in patients who underwent Home Teeth Whitening	Recruitment completed	Intervention	2025-07-24	<NULL>	<NULL>	8153	Analysis of acute phase markers in patients undergoing at-Home Dental Bleaching:a blinded randomized controlled clinical trial	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2025-05-06	Universidade de Brasilia/ Departamento de odontologia	Universidade de Brasilia/ Departamento de odontologia	https://ensaiosclinicos.gov.br/rg/RBR-2hmgr4d	<NULL>	Patients aged between 18 and 40; both sexes; healthy; without active caries or periodontal disease and interested in whitening their teeth will be selected	Use of antimicrobials and immunosuppressants for less than three months; smokers; hospitalization and dental treatment within three months prior to the start of the study; pregnant and breastfeeding women; patients with unsatisfactory restorations; severe fluorosis; tetracycline staining	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-8mqxc4b	Use of Cannabidiol (CBD) Oil to relieve pain and burning in people with Burning Mouth Syndrome	Recruiting	Intervention	2025-07-24	<NULL>	<NULL>	8154	Evaluation of the analgesic effect of Cannabidiol (CBD) Oil on symptom reduction in patients with Burning Mouth Syndrome: a non-randomized controlled clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-03-01	Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8mqxc4b	<NULL>	Patients over 18 years of age; both genders; previous diagnosis of Burning Mouth Syndrome; diagnosed during the study	history of Liver Disease; using Anticoagulants; family history of Schizophrenia; symptoms associated with other comorbidities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-4x5dhpc	Tests are being carried out to verify whether the Psotran Fluid product is effective and safe for people with Psoriasis, Dermatitis and Ichthyosis	Recruitment completed	Intervention	2025-07-24	<NULL>	<NULL>	8155	Single-blind study of efficacy and safety of the product Psotran Fluid in humans suffering from Psoriasis, Dermatitis and Ichthyosis	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-31	Nipo Serviços Médicos SS Ltda	Instituto de Saúde e Bem Estar da Mulher	https://ensaiosclinicos.gov.br/rg/RBR-4x5dhpc	<NULL>	Patient of both sexes. Over 18 years old with a maximum age of 90 years. With lesions compatible with Psoriasis, Eczema and Ichthyosis, in the initial phase of treatment	Pregnancy. Neonates. Sensitivity to drug components	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:46
RBR-8fg9w54	Use of an Obesity classification system to facilitate the referral of obese people to Bariatric Surgery	Recruiting	Observational	2025-07-23	<NULL>	<NULL>	8150	Application of the Edmonton Obesity Staging System as a strategy to enhance the treatment of Obesity through Bariatric Surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-01	Centro de Ciências da Saúde da Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco - HC-UFPE	https://ensaiosclinicos.gov.br/rg/RBR-8fg9w54	<NULL>	Both sexes; undergoing bariatric surgery of the Gastric Sleeve or Roux-en-Y Gastric Bypass (RYGB) type; age between 18 and 60 years; Body Mass Index (BMI) greater than or equal to 35 kg/m2; undergoing surgery at the Clinical Hospital of the Federal University of Pernambuco (CH-FUPE)	Other surgical techniques or repairs; do not have all the data necessary for the evaluations recorded in the medical records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-54ckvrj	Laser helps reduce tooth Sensitivity after whitening: a patient-based study	Recruitment completed	Intervention	2025-07-23	<NULL>	<NULL>	8151	Effect of Low-Level Laser therapy on reducing post-whitening Sensitivity: a split-mouth randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-24	Centro Universitário Univel	Centro Universitário Univel	https://ensaiosclinicos.gov.br/rg/RBR-54ckvrj	<NULL>	Patients of both sexes; aged between 18 and 30 years; with all vital anterior teeth present; never whitened or restored; and presenting central incisors with shade A2 or darker, according to the Vitapan Classical shade guide (Vita, Bad Säckingen, Germany)	Patients with missing anterior teeth; affected by carious lesions; with gingival recession; with any type of restorative or prosthetic treatment; with a history of dentin hypersensitivity; presenting dental discoloration due to tetracycline or fluorosis; using continuous medications such as anti-inflammatory drugs or analgesics; or who were pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-6s85dyj	Evaluation of Cannabis extract Ointment to help treat Neuropathy in Diabetes patients	Recruiting	Intervention	2025-07-22	<NULL>	<NULL>	8146	Effect of Ointment containing Cannabis extract rich in Cannabidiol 1% as an adjuvant in the treatment of Diabetic Neuropathy: randomized controlled clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-07-15	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Policlínica Universitária Piquet Carneiro da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6s85dyj	<NULL>	In phase one, non-diabetic individuals will be included; aged between 40 and 60 years; both sexes; without comorbidities; not using or consuming, during the evaluation period, any Cannabis-based product; in phase two, individuals aged between 50 and 75 years will be included; of both sexes; with a diagnosis of Diabetes with Peripheral Neuropathy previously defined by the endocrinology team, in accordance with the protocols and guidelines adopted by the multidisciplinary team of the outpatient clinic; who present moderate or severe pain intensity, defined as a score equal to or greater than 4 on the Visual Numeric Scale, and a score greater than or equal to 4 on the Questionnaire for the diagnosis of neuropathic pain; recent blood glucose and glycated hemoglobin tests; history of attendance at medical appointments at the outpatient clinic	In phase one, patients under 40 and over 60 years of age will be excluded; those who have not consumed cannabis-based products; in phase two, patients under 50 and over 75 years of age will be excluded; patients with untreated active lesions; patients in continuous use of opioids, anti-inflammatories and/or use of cannabis derivatives by any route and/or dependence; patients with decompensated organic comorbidities and/or high-risk psychiatric conditions; current pregnancy or lactation; patients unable to understand the study protocol due to cognitive dysfunction or untreated psychiatric illness; report of sensitivity to cannabinoids, addressed in the first interview/evaluation, on an individual basis, respecting the participant&apos;s desire for confidentiality	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-7jgdk6y	Monthly and quarterly mesotherapy in the treatment of male Pattern Baldness	Recruitment completed	Intervention	2025-07-22	<NULL>	<NULL>	8148	Mesotherapy with Dutasteride 0.1% monthly versus quarterly in the treatment of male Androgenetc Alopecia: Randomized double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Clinica Sanabria Transplante e Restauração Capilar	Hospital Universitário Maria Aparecida Pedrossian da Universidade Federal do Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7jgdk6y	<NULL>	Males; age between 25 and 50 years; diagnosis of male androgenetic alopecia classified as grades 3V, 4V or 5V on the Norwood-Hamilton scale	Patients who present any other causes of hair loss other than exclusively androgenetic alopecia; known hypersensitivity to dutasteride; previous diagnosis of erectile dysfunction; use of therapy aimed at increasing hair density in the last four months; patients with insulin-dependent diabetes mellitus; history of stroke, cancer, thromboembolic phenomena or use of anticoagulant medications; patients with a previous history of psoriasis or lichen planus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-3qmg5nj	Assessment of distal temperature before and after the use of positive airway pressure in patients with sleep apnea according to preferred times for sleeping and waking up	Not yet recruiting	Intervention	2025-07-22	<NULL>	<NULL>	8149	Assessment of distal temperature before and after the use of Positive Airway Pressure device in patients with Obstructive Sleep Apnea according to chronotype	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-30	Faculdade de Saúde Pública da Universidade de São Paulo	Departamento de Saúde e Sociedade da Faculdade de Saúde Pública da Universidade de São Paulo FSP/USP	https://ensaiosclinicos.gov.br/rg/RBR-3qmg5nj	<NULL>	Patients of both sexes;aged18 years or older; with a diagnosis of moderate or severe obstructive sleep apnea; who are beginning the adaptation process to Positive Airway Pressure (CPAP) with a nasal mask indication, will be recruited	Patients presenting with other sleep disorders as insomnia; parasomnias; narcolepsy; central sleep apnea; uncontrolled clinical disease as diabetes; renal or cardiac failure; recent stroke or coronary insufficiency; recent postoperative period; Chronic obstructive pulmonary disease; oxygen dependence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-9f62ht4	Hathayoga and stress regulation in adult women	Recruitment completed	Intervention	2025-07-21	<NULL>	<NULL>	8140	Effects of hathayoga on stress and autonomic nervous system modulation in apparently healthy adult women: an extraordinary clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-13	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9f62ht4	<NULL>	Women; aged between 18 and 50 years; who have symptoms of stress and who score at least 20 points on the Stress Perception Scale-10 (PSS-10); who are not in menopause; who are not exercising regularly; who have had less than one year or no experience with the practice of Yoga	Women with diagnosis of non-communicable chronic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-4wtmxst	Efficacy of Biovidro 45s5 in the treatment of Dentin Hypersensitivity: randomized clinical trial	Recruitment completed	Intervention	2025-07-21	<NULL>	<NULL>	8141	The effect of Bioglass in the treatment of Dentin Hypersensitivity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Programa de Pós-Graduação em Odontologia da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4wtmxst	<NULL>	Patients over 18 years of age; both genders - male and female; good oral hygiene; without periodontal disease or dysfunctional habits; who have at least one cervical lesion in the quadrant diagnosed as moderate or severe hypersensitivity	Desensitizing treatment in the last six months; history of chronic use of medications such as antidepressants, antihistamines, nonsteroidal anti-inflammatory drugs, anticonvulsants or sedatives; history of allergies to dental products; pregnant or lactating patients; orthodontic appliances; the selected teeth should not have pulpitis, crowns, abutments, extensive or defective restorations on the vestibular surface, nor cracks in the enamel, fractures or cavities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-102fn4kd	The effect of Strength Exercise with Blood Flow Restriction using different Pressure Levels in the elderly	Not yet recruiting	Intervention	2025-07-21	<NULL>	<NULL>	8143	Physiological marker responses to Resistance Exercise with Blood Flow Restriction using different Occlusion Pressures in older adults	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Felipe Corbellini	Universidade Comunitária da Região de Chapecó - Unochapecó	https://ensaiosclinicos.gov.br/rg/RBR-102fn4kd	<NULL>	The study will include elderly individuals aged 60 to 70 years old; of both genders; and who do not have a routine of systematic physical exercise.	Individuals with severe arterial and/or venous insufficiency (assessed by VLab-4000); joint or mobility problems that prevent and/or limit the performance of the exercises predetermined by the protocol; and endocrine dysfunctions related to the biomarkers analyzed in the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-8gbnr2x	Healthy volunteer study to test the safety of an antibiotic combination	Not yet recruiting	Intervention	2025-07-21	<NULL>	<NULL>	8144	A phase I, randomized, double-blind, placebo-controlled, multiple-dose study to evaluate the safety, tolerability, and pharmacokinetics of Pitavastatin+Polymyxin B (Pva+Pmx), Desloratadine+Meropenem (Des+Mpm), and Ceftibuten+Polymyxin B (Cef+Pmx) in healthy adults	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Evangélica de Goiás	Universidade Evangélica de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8gbnr2x	<NULL>	Healthy adult men and women of non-childbearing potential. aged 18 to 55 years. Body mass index between 18.5 kilograms per square meter and 29.9 kilograms per square meter and body weight between 55.0 kilograms and 100.0 kilograms. No clinically significant abnormalities at screening or on Day 1, including vital signs within normal parameters (temperature, Normal heart rate, respiratory rate, and blood pressure), Normal electrocardiograms, hemoglobin/hematocrit, white blood cell count and platelet count greater than or equal to the lower limit of normal, serum creatinine less than 1.4 milligrams per deciliter, serum urea nitrogen less than 40 milligrams per deciliter, alanine aminotransferase and aspartate aminotransferase less than 50 units per liter	History or presence of significant cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, or neurologic disease that may increase the risk of adverse effects from study medications. History of confirmed or suspected Clostridium difficile infection. History of seizure disorders. Positive urine drug or alcohol test during screening. Positive test for human immunodeficiency virus (HIV), Positive test for hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV). History of substance or alcohol abuse that increases the risk of adverse effects from study medications. Use of any prescription or over-the-counter medication; use of herbal products; use of vitamins; use of dietary supplements or hormonal supplements in the seven days prior to randomization. Documented hypersensitivity or anaphylaxis to any medication. Donation of blood or plasma in the thirty days prior to randomization, total blood loss greater than 500 milliliters in the thirty days prior to randomization, or blood transfusion in the one year prior to study enrollment. Participation in a clinical trial involving a New Chemical Entity in the last three months or a marketed drug in the thirty days prior to the first dose of the study drug. Any other condition or prior therapy that would make the volunteer unsuitable for the study, inability to fully comply with the study protocol or likely non-compliance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-95mw4qm	Benefits of Health Education using an Educational Booklet for Hemodialysis patients	Recruiting	Intervention	2025-07-21	<NULL>	<NULL>	8145	Effectiveness of an Educational Booklet in promoting self-care among Hemodialysis patients with Arteriovenous Fistula	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-24	Universidade Estadual do Ceará	Hospital Universitário Walter Cantídio da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-95mw4qm	<NULL>	to be 18 or older; both sexes; followed up in the Hemodialysis service with via permanent vascular access of the Arteriovenous Fistula type; Hemodialysis started at least four weeks ago; be able to read and understand the booklet	incapacitating Mental Illness; being homeless; living in a collective shelter or deprived of liberty; having a non-functioning Arteriovenous Fistula	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-6wz472d	Modified thoracoabdominal nerve block by perichondral approach guided by Ultrasonography in patients undergoing Laparoscopic Sleeve Gastroplasty: a prospective study	Recruiting	Intervention	2025-07-19	<NULL>	<NULL>	8138	Modified thoracoabdominal nerve block via perichondrial approach (M-TAPA) in patients undergoing laparoscopic sleeve gastroplasty: a prospective study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Hospital São Domingos	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6wz472d	<NULL>	Age between 18 and 65 years; both sexes; American Society of Anesthesiologists (ASA) physical status II or III; patients undergoing Sleeve type bariatric surgery	Severe comorbidity with American Society of Anesthesiologists (ASA) physical status IV; cardiac arrhythmias; dilated cardiomyopathy; cardiac conduction disturbance; electrolyte disturbance; acid-base disturbance; hypersensitivity to lidocaine; psychiatric, hepatic, respiratory or oncological diseases, who are receiving any type of analgesic in the week before surgery; patients receiving hemoderivatives during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:19
RBR-46kgpmz	Use of Vibration Platform to increase muscle strength and improve performance in amateur street runners	Not yet recruiting	Intervention	2025-07-19	<NULL>	<NULL>	8139	Whole Body Vibration in the response of muscle strength and performance in amateur street running athletes: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Centro Universitário Augusto Motta - UNISUAM	Centro Universitário Augusto Motta - UNISUAM	https://ensaiosclinicos.gov.br/rg/RBR-46kgpmz	<NULL>	Amateur street runners; aged between 18 and 59; of both genders	Recent surgeries; prosthetic surgeries; osteoporosis; uncontrolled hypertension; metal prosthesis;recurrence of osteosynthesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-10sq7mnk	Effects of dual-task training on gait in elderly people	Recruiting	Intervention	2025-07-17	<NULL>	<NULL>	8135	Effects of dual-task training on the gait of physically active and institutionalized elderly people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade de Caxias do Sul	Universidade de Caxias do Sul	https://ensaiosclinicos.gov.br/rg/RBR-10sq7mnk	<NULL>	Elderly people over the age of 60, who are clinically stable and without acute health conditions that could compromise participation in the training, will be included in the study. Literate individuals, with sufficient cognitive capacity to understand the instructions given. Elderly people who maintain the ability to walk independently, without motor restrictions that prevent participation in training. Everyone who agrees to participate voluntarily and who signs the Free and Informed Consent Form	Individuals who present a cognitive deficit or insufficient level of understanding to perform the tests, who present functional limitations to walking (disabling pain and/or sequelae of neurological or orthopedic diseases) will be excluded. Individuals with motor restrictions and the presence of diseases that make it impossible for participants to complete the protocol. Elderly people who are not able to walk independently and who use assistive devices for mobility. Furthermore, participants involved in other similar training programs during the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-32by67h	Lifestyle and mental health in adolescents	Not yet recruiting	Intervention	2025-07-17	<NULL>	<NULL>	8136	An experimental study between lifestyle and mental health in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-32by67h	<NULL>	Healthy volunteers; both genders; aged between 11 and 17 years; agree to participate in the study by signing the consent forms by their guardian and assent by the participant	Self-report of diagnosis of psychiatric disorders; self-report of use of alcohol or drugs; physical inability to perform physical exercise; food intolerance to some food; participant who does not participate in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-2qvhp8w	Frailty Assessment, Telomere Length, and Postoperative Outcomes in Cardiac Surgery Patients	Data analysis completed	Observational	2025-07-17	<NULL>	<NULL>	8137	Funtionality Assessment and Telomere Length to predict surgical complications in patients undergoing Cardiac Surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2qvhp8w	<NULL>	Volunteers undergoing elective cardiac surgery for myocardial revascularization or to correct heart valve diseases with cardiopulmonary bypass; over 18 years old; all genders; all ethnicities	Emergency surgery; other associated cardiovascular procedure; acute myocardial infarction  less than 30 days before operation; unstable angina;  orthopedic or neurologic disorders that prevented or made it difficult to perform the functional tests; functional class IV of the NYHA	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-6vj7z9h	Evaluation the pain level of migraine patients after inhalation of essential oils: a randomized clinical trial	Recruiting	Intervention	2025-07-16	<NULL>	<NULL>	8133	Evaluation of pain thresholds in migraine patients after inhalation of essential oils: a randomized clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-03-14	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6vj7z9h	<NULL>	Volunteers of all genders; aged between 18 and 60 years; mentally competent; diagnosed with chronic or episodic migraine; with or without prophylactic medication; according to the International Classification of Headache Disorders criteria	Volunteers with severe acute circulatory disorders; diabetes mellitus; uncontrolled arterial hypertension; fibromyalgia; cognitive impairments; anosmia or hyposmia after COVID-19; allergy to substances present in essential oils; pregnancy and lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-732s44x	Linear regression between cerebral oximetry and hematocrit during acute normovolemic hemodilution	Recruitment completed	Intervention	2025-07-15	<NULL>	<NULL>	8129	Evaluation of the impact of Acute Normovolemic Hemodilution on cerebral oximetry in patients undergoing major non-cardiac surgeries	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2024-08-12	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-732s44x	<NULL>	The target population was patients undergoing general anesthesia for major non-cardiac surgeries; age were between 18 and 65 years old; classified as class I or II by the American Society of Anesthesiology; both male and female	Patients who refused or withdrew from participation were excluded. Patients with arrhythmias; heart failure; previous heart attacks; restrictive or obstructive lung diseases; significant renal dysfunction (creatinine clearance &lt; 60 mg/L/min) or who had an oliguric or anuric presentation were also excluded; Patients with a preoperative hematocrit lower than 30% were also excluded, except in contexts in which the patient refused to receive blood transfusions, making this limitation less restrictive given the benefit in these cases; Patients undergoing laparoscopic surgeries; neurosurgeries; Surgeries in which neuraxial anesthesia was associated intraoperatively were also excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-85tkdz5	Sacred Dances versus physical training on Heart Failure	Not yet recruiting	Intervention	2025-07-15	<NULL>	<NULL>	8130	Effects of sacred dances versus physical training on Heart Failure a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-05	Fundação Bahiana para o Desenvolvimento da Ciência	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-85tkdz5	<NULL>	Women; ages 18 to 70; Heart Failure Class I, II or III according to the New York Heart Association; no regular physical exercise for 3 months; ability to perform moderate physical activities	Clinical conditions of any nature that prevent the performance of physical activities; chronic kidney disease requiring dialysis; oxygen desaturation during exercise; complex ventricular arrhythmias at rest or during exercise; hospitalization due to cardiovascular decompensation, acute myocardial infarction, surgical or percutaneous revascularization, complex arrhythmias or sudden reversed death; social incapacity to attend the proposed sessions; serious cognitive or psychiatric problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-9bw8xtd	Orofacial Therapy with a palatal plate in infants with Down Syndrome	Recruitment completed	Intervention	2025-07-15	<NULL>	<NULL>	8131	Orofacial Proprioceptive Stimulation Therapy with a memory palatal plate in infants with Down Syndrome – a non-randomized clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Centro universitário Christus	Centro universitário Christus	https://ensaiosclinicos.gov.br/rg/RBR-9bw8xtd	<NULL>	Patients with Down Syndrome; age between 2 months and 2 years; both sexes; with Hypotonia of the facial muscles; Macroglossia; protruding flaccid tongue and insufficient lip seal; patients who are able to attend for treatment and maintenance with the memory palatal plate; patients who agree to invest in the minimum laboratory cost for the production of the memory palatal plate	Patients with Down Syndrome over 2 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-8hqz6s6	Evaluation of the use of removal solution in the prevention of Injuries caused by medical adhesives	Not yet recruiting	Intervention	2025-07-15	<NULL>	<NULL>	8132	Effect of removal rolution in preventing the occurrence of medical adhesive-related Injuries (MARSI): randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-05	Hospital das Clínicas da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8hqz6s6	<NULL>	Individuals of both sexes; aged 18 years or older; who have undergone compression dressings with medical adhesives following endovascular procedures; elective or emergency procedures; hospitalized after the procedure	Presence of previous skin lesions or lesions adjacent to the area where the compressive dressing will be applied	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-4x7w9kj	How patients perceive the preoperative use of Passiflora Incarnata in wisdom tooth extraction	Data analysis completed	Intervention	2025-07-14	<NULL>	<NULL>	8126	The patient&apos;s perception of the preemptive use of Passiflora Incarnata in third molar extraction	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-07-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Pró Reitoria de Pesquisa da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4x7w9kj	<NULL>	Be between 18 and 40 years old; both genders; have two asymptomatic homologous third molars (upper or lower); same classification as Pell and Gregory and Winter for homologous teeth; same angulation of the third molars in relation to the second molars	Pregnant; lactating; American Society of Anesthesiologists (ASA) classification as patient III or IV; history of use of medication for pain or anxiety in the 15 days prior to the study; history of hypersensitivity to substances or materials used in the experiment; patients unable to undergo surgical procedures with local anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-2d9sfvj	Efficacy of a Hygiene Protocol for Patients Undergoing Maxillary Disjunction with Haas Palatal Expander	Recruiting	Intervention	2025-07-14	<NULL>	<NULL>	8127	Clinical Efficacy of a Professional Hygiene Protocol and its Impact on the Oral Microbiome of Patients Undergoing Maxillary Disjunction with Haas Palatal Expander: Randomized Controlled Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-02	Universidade Federal do Rio de Janeiro	Faculdade de Odontologia da Universidade Federal do Rio de janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2d9sfvj	<NULL>	Systemically healthy patients; mixed or permanent dentition phases; erupted upper incisors and first deciduous or permanent molars; maxillary atresia; feminine and masculine genders; 8 to 18 years old	Presence of systemic or periodontal disease; use of antibiotics or anti-inflammatories for up to six months; use of mouthwashes or antimicrobial gels for up to one month before or during treatment; smoking; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-2vmd7y7	Short-term Intraocular Pressure changes after intraocular injection of 0.05 mL of Aflibercept 40 mg/mL and 0.02 mL of Aflibercept 114.3 mg/mL	Recruiting	Intervention	2025-07-14	<NULL>	<NULL>	8128	Short-term Intraocular Pressure changes after intravitreal injection of 0.05 mL of Aflibercept 40 mg/mL and 0.02 mL of Aflibercept 114.3 mg/mL	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Federal de Pernambuco	Clínica Oftalmológica Zona Sul	https://ensaiosclinicos.gov.br/rg/RBR-2vmd7y7	<NULL>	DAge 18 years or older; male or female gender; diagnosis of neovascular age-related macular degeneration or clinically significant diabetic macular edema in one or both eyes, as defined by the Early Treatment Diabetic Retinopathy Study guidelines; best-corrected visual acuity between 0.3 and 1.3 LogMAR, inclusive; axial length between 22 and 25 mm, inclusive, as measured by optical low-coherence reflectometry (Lenstar LS900™, Haag-Streit™, Switzerland); central subfield thickness of 300 µm or greater, as measured by spectral-domain optical coherence tomography (Cirrus®, Zeiss™, Germany)	Any treatment for neovascular age-related macular degeneration or clinically significant diabetic macular edema within the preceding 4 months; panretinal photocoagulation performed within the preceding 4 months; any ocular surgery performed within the preceding 4 months, history of pars plana vitrectomy, history of open-angle glaucoma or corticosteroid-induced ocular hypertension requiring treatment with anti-glaucoma or ocular hypotensive medications, intraocular pressure &gt; 21 mmHg, known hypersensitivity to any substance used in the procedure, presence of tractional retinal detachment; inability or unwillingness to provide informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-2gp7wpt	Investigation of Venous Thrombosis markers profile in patients undergoing surgical treatment of Varicose Veins by Conventional Surgery and Endolaser	Recruitment completed	Intervention	2025-07-12	<NULL>	<NULL>	8124	Investigation of Venous Thrombosis markers profile in patients undergoing surgical treatment of Varicose Veins by saphenous vein Stripping and Endolaser Thermoablation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-06	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Hospital Estadual de Serrana	https://ensaiosclinicos.gov.br/rg/RBR-2gp7wpt	<NULL>	Symptomatic lower limb varicose veins; Age greater than 18 years and less than 80 years; Presence of total or partial reflux of unilateral great saphenous vein that can be treated with both methods (stripping and endolaser), detected in duplex ultrasound with indication for surgical treatment.	Significant underlying diseases in activity such as cancer, lupus, tuberculosis; Infectious disease (infected ulcers); History of coagulation disorders (thrombophilia); History of thromboembolic events (deep vein thrombosis); Use of anticoagulant or antiplatelet medication; Pregnancy; High cardiovascular risk; Bilateral involvement of the great saphenous vein or concomitant involvement of the small saphenous vein;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9rdw98s	Efficacy of Platelet-rich Fibrin in the treatment of Temporomandibular Joint Osteoarthritis	Recruiting	Intervention	2025-07-11	<NULL>	<NULL>	8116	Clinical study to evaluate Platelet-rich Fibrin in the control of Temporomandibular Osteoarthritis	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2025-01-24	Faculdade de Medicina de Petrópolis/Centro Universitário Arthur Sá Earp Neto	Faculdade de Medicina de Petrópolis/Centro Universitário Arthur Sá Earp Neto	https://ensaiosclinicos.gov.br/rg/RBR-9rdw98s	<NULL>	Patients diagnosed with Temporomandibular Joint (TMJ) osteoarthritis. Age above 18.	Patients in an advanced stage of osteoarthritis, with signs of generalized sclerosis in magnetic resonance image. Pregnant or breastfeeding patients (since the risks involved are not known). Patients with local infection. Patients with hereditary coagulopathies. Patients with rheumatological diseases. Patients under chronic use of corticosteroids and immunosuppressants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9r7yhzk	Biopsychosocial perspective of the home environment of children born with Gastroschisis: observational study	Data analysis completed	Observational	2025-07-11	<NULL>	<NULL>	8119	Evaluation of physical growth, body composition, and neuropsychomotor development of patients with Gastroschisis over the first two years of life: cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-01	Instituto Fernandes Figueira - IFF/ FIOCRUZ	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9r7yhzk	<NULL>	Children born with simple or complex gastroschisis; both sexes; between 3 and 4 months of corrected chronological age	Children with genetic syndromes; other congenital malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9kv6mqc	Effect of healthy habits on cardiovascular risk factors in patients with Ischemic Stroke or Transient Ischemic Attack	Recruiting	Intervention	2025-07-11	<NULL>	<NULL>	8120	Effect of healthy habits on cardiovascular risk factors in patients with Ischemic Stroke or TIA: a randomized study according to AHA Life’s Essential 8 health indicators	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-19	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9kv6mqc	<NULL>	Patients diagnosed with Ischemic Stroke or Transient Ischemic Attack (TIA) within the past 48 hours, with a modified Rankin score less than 2; aged 18 years or older; of both sexes; and with a signed informed consent form	Patients with severe chronic diseases that may interfere with the study (e.g., active cancer, advanced renal failure); severe psychiatric disorders; and/or inability to participate in educational and follow-up sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-2njtg49	Faster and safer hand surgery with innovative technique and efficient bleeding control	Recruitment completed	Intervention	2025-07-11	<NULL>	<NULL>	8121	Fast-track hand surgery using the Walant methodology and tranexamic acid-controlled hemostasis	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-12-01	Hospital de Caridade São Vicente de Paulo.	Hospital de Caridade São Vicente de Paulo.	https://ensaiosclinicos.gov.br/rg/RBR-2njtg49	<NULL>	Adults scheduled for elective carpal tunnel release surgery. Minimum age of 18 years. Both sexes. Patients classified as ASA I or II (low surgical risk, according to the American Society of Anesthesiologists). Participants who underwent surgical treatment for Carpal Tunnel Syndrome (CTS) between December 2022 and April 2023	Patients under 18 years of age. Patients with contraindications for the use of tranexamic acid (TA), including renal insufficiency, history of seizures, vascular insufficiency, individuals with cognitive deficits or anxiety disorders that could compromise the agreed surgical technique	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-6m67nb9	Blood Flow Restricted Walking Training for patients with Lung Disease	Not yet recruiting	Intervention	2025-07-11	<NULL>	<NULL>	8122	Effect of Walking Training combined with Blood Flow Restriction in patients with COPD and prolonged use of home Oxygen. Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6m67nb9	<NULL>	Patients of both sexes; aged 50 years or older; presenting with Chronic Obstructive Pulmonary Disease (COPD); using home oxygen; with an Modified Medical Research Council Scale  (mMRC) score between 1-3; who have clinically tested positive for at least two weeks; Review the Informed Consent Form	orthopedic or cognitive conditions that prevent them from performing functional capacity tests; , pulmonary embolism, stroke, acute myocardial failure, peripheral arterial disease; smokers; using beta-blocker medications; undergoing another form of non-drug treatment; patients who cannot tolerate the exercise session;exacerbation in the last two weeks; those who refuse to sign the Free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-5cgpv4t	Auditory Brainstem Response (ABR)) hearing test in children with speech delay: comparison between Inhalation and Intravenous Anesthesia	Not yet recruiting	Intervention	2025-07-11	<NULL>	<NULL>	8123	Auditory Brainstem Response (ABR) in children with language delay: comparison between Inhalation and Intravenous Anesthesia	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2026-02-25	Faculdade de Medicina da Universidade de São Paulo	Instituto de Pesquisa e Ensino em Saúde Infantil (PENSI)	https://ensaiosclinicos.gov.br/rg/RBR-5cgpv4t	<NULL>	Children under investigation for language delay or suspected autism spectrum disorder, or undergoing audiological monitoring, who are scheduled to undergo an auditory brainstem response under general anesthesia must present: transient otoacoustic emissions with at least four reproducible responses; distortion product otoacoustic emissions with at least four reproducible responses; and auditory brainstem responses demonstrating waves I, III, and V elicited by a click stimulus at 80 decibels	Suspected or confirmed genetic syndromes; american society of anesthesiologists physical status classification of three or higher; patients with middle ear pathology; non-portuguese speakers; clinical history of neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:09
RBR-4dqtygd	Faculty training in realistic simulation	Recruitment completed	Intervention	2025-07-10	<NULL>	<NULL>	8113	Effectiveness of a training program for facilitators in realistic simulation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Instituto e Centro de Pesquisas São Leopoldo Mandic.	Instituto e Centro de Pesquisas São Leopoldo Mandic.	https://ensaiosclinicos.gov.br/rg/RBR-4dqtygd	<NULL>	Teachers and health professionals; of both sexes	Do not participate in face-to-face meeting days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-7pjwxp6	Vancomycin treatment optmization in neonatal and pediatric population using machine learning tools and statistical modeling	Recruiting	Observational	2025-07-10	<NULL>	<NULL>	8114	Vancomycin model-informed precision dosing and proposal of new PK-PD effectiveness indices through machine learning and statistical modeling in neonatal and pediatric populations	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7pjwxp6	<NULL>	Neonatal and pediatric patients (0 to 18 years old); of both sexes; who received vancomycin and underwent therapeutic drug monitoring trough vancomycin serum concentration	Adults patients (18 years and above)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-59vbvjq	How patient expectation affects back pain relief with TENS: a clinical study	Recruiting	Intervention	2025-07-10	<NULL>	<NULL>	8115	Influence of patient expectations on TENS treatment in chronic low back pain: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Universidade Estadual do Norte do Paraná	Universidade Estadual do Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-59vbvjq	<NULL>	Minimum age of 18 years; persistent low back pain for more than 12 weeks; moderate to severe pain (at least 3 points on the Visual Analogue Scale of pain); be able to understand and answer the questionnaires; both genders	Possibility of pregnancy or pregnant women; research participants who have neoplasms and tumors; research participants with cardiac pacemakers; research participants with significant skin irritations or (open wounds) at the TENS application site; research participants who have a diagnosis of fractures in the lumbar vertebrae; research participants who have serious neurological conditions or who have loss of sensation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:14
RBR-102g7f3m	Effects of ear Acupuncture on the Mental Health of college students: a clinical study	Not yet recruiting	Intervention	2025-07-09	<NULL>	<NULL>	8109	Auricular Acupuncture in the treatment of Emotional Disorders in university students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-102g7f3m	<NULL>	Postgraduate strictu sensu students who present moderate or high levels of anxiety, stress, and/or depression according to the Depression, Anxiety, and Stress Scale (DASS-21); who agree to be randomly allocated to the study groups; of both genders; and who are 18 years of age or older	Ear piercings (except in the earlobe); history of allergy to metal or microporous tape; history of photosensitivity; injury, inflammation, deformity, or tattoos on the ear; history of skin cancer in the head and neck region; use of hearing aid; use of chemical peels (such as retinoic acid, retinol, Vitanol-A, tretinoin, isotretinoin) and/or Roaccutan® (Isotretinoin) up to six months prior to the start of treatment; individuals with compromised immune systems (e.g., undergoing cancer treatment or using immunosuppressive medications); epilepsy; use of a cardiac pacemaker; pregnant or breastfeeding women, or those planning to become pregnant during the study period; rejection of or fear of receiving the technique; and undergoing any other form of energy therapy concurrently with the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-5nwn9xf	Study on the use of electrical stimulation of the brain and spinal cord to improve the strength of respiratory muscles	Recruiting	Intervention	2025-07-09	<NULL>	<NULL>	8110	Study of the use of Bilateral Anodal and Cathodal Direct Current Stimulation under the Primary motor cortex and spinal cord in gaining respiratory muscle strength and endurance: a double-blind, randomized clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-5nwn9xf	<NULL>	Both sexes. Distributed into two distinct age groups the young group composed of individuals aged between 18 and 25 years, and the elderly group, composed of individuals aged between 60 and 75 years. All participants, regardless of the group, must have a body mass index (BMI) between 17 and 24.9, normal lung function, with forced expiratory volume in one second (FEV1) values ​​greater than 80%, forced vital capacity (FVC) greater than 80% and FEV1/FVC ratio greater than 70%. In addition, volunteers must not have diagnosed cardiovascular diseases, nor motor alterations in the upper limbs that prevent the assessment of isometric handgrip strength	Individuals from both groups who have diagnosed chronic respiratory diseases, as well as those who are smokers or ex-smokers who have quit smoking for less than six months. Participants who abuse alcohol (alcoholics), who have been diagnosed with type I or type II diabetes, or who have any other metabolic syndrome or diagnosed rheumatic disease. Specifically for the elderly group, individuals with cognitive impairment will be excluded, as defined by scores below 18 points on the Mini-Mental State Examination (MMSE), previously administered by an experienced examiner	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-62thzgq	Study on the strength of the thigh muscles and how it relates to knee movements measured by sensors	Recruiting	Observational	2025-07-09	<NULL>	<NULL>	8111	Relationship, reproducibility and responsiveness of quadriceps and hamstring muscle endurance measurements with knee accelerometry using the SMMAR-T system: a cross-sectional observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-13	Centro de Ciências Biológicas e da Saúde da Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-62thzgq	<NULL>	People of both sexes; between 18 and 65 years old	Participants who present neurological and/or cognitive impairments; cardiorespiratory diseases and/or history of joint and/or muscle injury in the last six months or during the evaluation period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9tdngmz	Efficacy of Laser use in root canal treatment of deciduous teeth: a randomized clinical study	Not yet recruiting	Intervention	2025-07-09	<NULL>	<NULL>	8112	Efficacy of Photodynamic Therapy associated with potassium iodide in endodontic Treatment of Primary teeth: a ramdomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-20	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9tdngmz	<NULL>	Children of both genders; presenting at least one deciduous molar with a diagnosis of irreversible pulpitis or pulp necrosis; age between 5 and 9 years; with root resorption of a maximum of 1/3 of the roots; presence of the crypt of the permanent tooth and with sufficient dental structure to allow absolute isolation of the surgical field and subsequent restoration; children with positive behavior during the consultation	Children with any systemic alteration; history of allergic reaction to any medication; have used antibiotics in the last three months; systemic manifestation fever and extraoral abscess; negative behavior	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-6rdvyt4	Auriculotherapy for pain in people taking medication	Recruitment completed	Intervention	2025-07-08	<NULL>	<NULL>	8108	Auriculotherapy as an Analgesia strategy for users of chronic pain medications in primary health care	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-13	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6rdvyt4	<NULL>	Women; users of continuous analgesics, anti-inflammatories and opioids; who collect them at the Ijuí Municipal Pharmacy; with a minimum collection frequency of three consecutive months; age between 18 and 60; complete at least 8 Auriculotherapy sessions	Pregnant women; those who are unable to speak, see and hear; medically diagnosed with cognitive deficit; oncological diseases; serious autoimmune diseases; use of immunobiological drugs; who do not accept to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-82gmkbt	Effects of Whole-Body Muscle Electrostimulation associated with whey protein supplementation on physical capacities,hypertrophy, glycemia control and advanced glycation products (age) in elderly patients with Type 2 Diabetes Mellitus:triple blind randomized trial	Recruitment completed	Intervention	2025-07-07	<NULL>	<NULL>	8101	Effects of Whole-Body Electrostimulation associated with protein supplementation on physical capacities, glycemic control, and age formation in elderly Type 2 Diabetics compared to non-Diabetics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-05	Universidade São Judas Tadeu	Universidade São Judas Tadeu	https://ensaiosclinicos.gov.br/rg/RBR-82gmkbt	<NULL>	Stable dose of medication (oral antidiabetics or insulin or combination of both) for three or more months; glycated hemoglobin between 6 and 10.0%; renal function assessed by the Modification of Diet in Renal Disease (MDRD) above 60 ml/h; Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) up to 2.5 times the upper limit of the method; no impairment of the musculoskeletal system, disabling disease or previous surgeries that would prevent the exercise; no chronic non-communicable disease not adequately treated and decompensated, especially systemic arterial hypertension (SAH); does not use a pacemaker; age between 65 and 79 years; both sexes	Impossibility of carrying out evaluations and reevaluations and during the period; having more than three consecutive absences	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-5w8bgmk	Clinical Evaluation of two Unicrhomatic Resins in Non-Carious Cervical Lesions	Recruitment completed	Intervention	2025-07-07	<NULL>	<NULL>	8102	Clinical evaluation of two Unicrhomatic Resins in Non-Carious Cervical Lesions: a randomized, triple-blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5w8bgmk	<NULL>	Patients ASA (American Society of Anesthesiologists classification) I and II; age between 18 and 65 years; good oral hygiene; may be male or female; present at least 20 teeth in occlusion; present at least 2 NCCLs (Non-carious cervical lesions), with a depth greater than 1 mm	People with periodontal disease (probing depth up to 3 mm, bleeding, or mobility up to grade II); people with parafunctional habits; smokers; patients with orthodontic appliances; teeth that serve as prosthetic abutments; pregnant women; people who do not agree with the terms of the research or who have difficulties attending the follow-up appointments after the restoration is performed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-4hrvmkb	How the carotid artery reacts to mental stress: a new test to assess blood vessel health	Recruitment completed	Intervention	2025-07-07	<NULL>	<NULL>	8103	Carotid artery reactivity to mental stress: a potential new test for assessing vascular function	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4hrvmkb	<NULL>	Young adult men and women; between 18 and 40 years old	Participants who reported a history of cardiovascular or metabolic diseases, infectious or inflammatory processes; people with a history of cognitive deficit; waist-to-height ratio greater than 0.5; smokers; people who used drugs that could influence the variables analyzed; very active or sedentary people; women with an intrauterine device	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-3n8w4pc	The effect of transdermal devices on bruxism	Recruitment completed	Intervention	2025-07-07	<NULL>	<NULL>	8104	Evaluation of a Transdermal Device for the complementary treatment of Bruxism	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-20	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3n8w4pc	<NULL>	Male and female patients. Age range between 18 and 70 years old. Report of severe bruxism. Who do or do not use myorelaxing interocclusion plates	Patients with mild bruxism. Patients with bruxism in sporadic situations. Patients reporting allergies to lidocaine. Patients with skin lesions on the face	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-6dx6fq4	The relationship between quick strength and power in the muscles that straighten the knee: what we observed in a study with people	Recruiting	Observational	2025-07-07	<NULL>	<NULL>	8105	Correlation between torque development rate and muscle power of knee extensors: a cross-sectional observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-28	Centro de Ciências Biológicas e da Saúde da Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6dx6fq4	<NULL>	Amateur volleyball athletes; long-distance street and crossfit runners; of both sexes; aged between 18 and 45 years	Participants who present neurological and/or cognitive impairments; cardiorespiratory diseases and/or a history of joint and/or muscle injuries in the last six months or that occur during the collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-7ktpgx7	Evaluation of the Analgesic effect of Lidocaine when used Topically or Intravenously before Tracheal Intubation in patients under General Anesthesia	Recruitment completed	Intervention	2025-07-07	<NULL>	<NULL>	8107	Evaluation of the Antinociceptive effect of Topical or Intravenous Lidocaine prior to Tracheal Intubation in patients undergoing General Anesthesia	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal de São Paulo - UNIFESP/EPM	Hospital São Paulo - SPDM	https://ensaiosclinicos.gov.br/rg/RBR-7ktpgx7	<NULL>	Patients indicated for elective surgical interventions under general anesthesia and tracheal intubation; both genders; age between 18 and 80 years; American Society of Anesthesiologists physical status classification ASA I or II	Emergency procedures; psychiatric disorders; suspected difficult airway; contraindication to manual ventilation under a face mask; use of beta-blockers; cardiac arrhythmia; use of opioids or other illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-10g9mjqk	Comparison between two types of surgery to treat Penile Cancer	Recruiting	Intervention	2025-07-04	<NULL>	<NULL>	8098	Comparative study between robotic inguinal lymphadenectomies and pen inguinal lymphadenectomies in patients with Penile Cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-20	Instituto do Câncer do Ceará	Instituto do Câncer do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10g9mjqk	<NULL>	Men with Squamous Cell Carcinoma - SCC of the penis; minimum age 18 years; patients without clinical suspicion of lymph node involvement , but with an intermediate-risk penile tumoror high-risk ; patients with clinical suspicion of lymph node involvement, but with lymph nodes up to 3 cm and not fixed to the skin or deeper structures and without distant metastases	Patients without clinical suspicion of lymph node involvement and with low-risk penile tumor ; patients with clinical suspicion of lymph node involvement, but with lymph nodes larger than 3 cm and/or fixed to the skin or deeper structures and/or distant metastases; patients undergoing neoadjuvant radiotherapy or chemotherapy; dementia, psychiatric or cognitive status that prevents full understanding of the explanations and implications of the research project and treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-8ygm86f	Treatment of male pattern baldness with topical Dutasteride	Recruitment completed	Intervention	2025-07-04	<NULL>	<NULL>	8099	Topical Dutasteride in the Treatment of Male Pattern Alopecia	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2024-04-05	Clinica Sanabria Transplante e Restauração Capilar	Hospital Universitário Maria Aparecida Pedrossian da Universidade Federal do Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8ygm86f	<NULL>	Males; Age between 20 and 60 years; Diagnosis of Androgenetic Alopecia grades 3V, 4V or 5V on the Norwood-Hamilton scale	Patients who have undergone hair loss treatment in the last 4 months; those with systemic arterial hypertension; heart disease; kidney disease; those with other causes of hair loss or scalp dermatoses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-9f3whw9	Phage therapy for the decolonization of specific multidrug resistant bacteria in high-risk patients	Not yet recruiting	Intervention	2025-07-04	<NULL>	<NULL>	8100	Building a decolonization model using phages against KPC producing Klebsiella pneumoniae in high risk patients: a prospective feasibility and proof of concept study	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9f3whw9	<NULL>	Patients of both genders; active hematological or oncological condition; use of immunosuppressive medications; history of infection by Klebsiella pneumoniae producing Klebsiella pneumoniae carbapenemase with high risk of recurrence; planned surgery with high risk of infectious complication; sufficient time window to administer at least 7 days of phage therapy; positive rectal swab for Klebsiella pneumoniae producing Klebsiella pneumoniae carbapenemase; availability of a combination of phages active against the patient’s isolate; age over 18 years; signed informed consent from the patient	Patients without informed consent signed; pregnancy; breastfeeding; hemodynamic instability; any other acute and severe organ dysfunction; antibiotic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-8y9z94y	EN23-0216-08_Evaluation of gynecological acceptance and pH balance, considering perceived effectiveness	Not yet recruiting	Intervention	2025-07-02	<NULL>	<NULL>	8094	EN23-0216-08_Assessment of gynecological acceptability and pH maintenance with perceived efficacy	<NULL>	2, single-arm-study, single-blind	2	<NULL>	<NULL>	<NULL>	2025-08-14	Medcin Instituto da Pele Ltda	Medcin Instituto da Pele Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8y9z94y	<NULL>	Female population; female participants aged between 18 and 60 years; participants with an active sex life; participants with a vaginal pH value between 3.8 and 4.5; intact skin in the area of product application (vaginal mucosa); current user of products in the same category; willingness to follow the study procedures and attend the Clinical Research Center on the scheduled days and times for evaluations; understanding, agreement with, and signing of the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy and/or lactation (for women); sexually transmitted infections, such as candidiasis, trichomoniasis, or conditions that compromise the safety evaluation of the product; use of anti-inflammatory drugs, immunosuppressants, or antihistamines up to 3 weeks before selection; skin markings in the experimental area that interfere with the evaluation of possible skin reactions, such as vascular malformations, scars, increased hair growth, numerous nevi, or sunburns; atopic or allergic history to products in the same category; active skin pathologies or lesions (local or disseminated) in the evaluation area; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; relevant clinical history or current evidence of alcohol or drug abuse; known or suspected intolerance to products in the same category; intense sun exposure up to 15 days before evaluation; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; other conditions deemed reasonable by the investigator for disqualification from participation in the study, which should be described in the clinical record observation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-5nfpn48	Evaluation of hand strenght after Indirect Muscle Activation concomitant with a Mental Task, Laser Application and Pavilion Stimulation	Not yet recruiting	Intervention	2025-07-02	<NULL>	<NULL>	8095	Evaluation of Handgrip strenght after Overflow of non-homologous muscles concomitant with Cognitive Dual Task, Laser and Auricular Stimulation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5nfpn48	<NULL>	Healthy individuals; both sexes; aged between 18 and 30; motor preference for the right upper limb	Participants will be excluded if they have orthopedic alterations, pain, difficulty in performing the palmar grip and index finger flexion movements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-46kd834	Physical Exercises for patients with Chronic Renal Failure	Recruiting	Intervention	2025-07-02	<NULL>	<NULL>	8096	Effect of Physical Exercise during Hemodialysis in patients with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-46kd834	<NULL>	Patients over 18 years of age; both sexes;  undergoing conventional dialysis treatment for more than 3 months with a weekly frequency of 3 times a week; with a urea reduction rate greater than 65% or Kt/V greater than or equal to 1.2; who have the conditions to carry out physical tests; and who accept to participate in the training protocol	Patients with cognitive or visual impairment; unstable angina; decompensated congestive heart failure; severe cardiac arrhythmias; pacemaker; uncontrolled arterial hypertension (systolic blood pressure greater than 200 mmHg and diastolic blood pressure greater than 100 mmHg at baseline); decompensated blood glucose (greater than 300 mg/dL); peripheral vascular disease in the lower limbs (such as deep vein thrombosis); disabling neurological sequelae; acute systemic infections; patients with orthopedic problems that prevent their participation; intolerance to electrical current or the electrode; and physically active patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-6rr5yq3	Effect of Lavandula angustifolia Essential Oil on the management of Facial Myalgia, Anxiety, and Bruxism	Not yet recruiting	Intervention	2025-07-02	<NULL>	<NULL>	8097	Efficacy of Lavandula angustifolia Essential Oil in reducing signs and symptoms of Myofascial Pain, Bruxism, and Anxiety in children and adolescents: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-20	Programa de Pós-Graduação em Odontologia da Universidade Federal do Paraná	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-6rr5yq3	<NULL>	Participants of both sexes, regardless of race or ethnicity, aged between 5 and 17 years; with a diagnosis of myalgia or myofascial pain according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD); and who present with related bruxism and anxiety	Participants who present with any cognitive impairment that prevents them from completing the questionnaires; whose guardians violate the study protocol, who demonstrate poor adherence to the treatment; or who provide information considered questionable by the investigators; children and adolescents with autoimmune diseases or syndromic conditions; those undergoing orthodontic treatment or those experiencing odontogenic pain; individuals using analgesic and/or anti-inflammatory medications within 48 hours prior to the start of the clinical assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-8y6j7w3	Evaluation of a brain stimulation technique for the treatment of people with cocaine dependence	Data analysis completed	Intervention	2025-07-01	<NULL>	<NULL>	8088	Transcranial Magnetic Stimulation in the treatment of Cocaine Dependence: evaluation of efficacy in a clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2024-10-01	Santa Casa de Misericórdia de Belo Horizonte	Santa Casa de Misericórdia de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-8y6j7w3	<NULL>	Being diagnosed with cocaine dependence according to the Diagnostic and Statistical Manual of Mental Disorders DSM-5 criteria. Age between 18 and 70 years. Undergoing treatment at the Psychosocial Care Center for Alcohol and Drugs CAPS AD for at least six months. Having stable use of psychotropic medications if applicable for at least three months prior to the start of the study. Both sexes	Have a history of electroconvulsive therapy (ECT). Brain implants. Stroke or traumatic brain injury in the last 12 months. Diagnosis of epilepsy. Diagnosis of brain malformations. Diagnosis of schizophrenia. Use of medications that interfere with cortical excitability. Hypersensitivity to magnetic stimuli	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-4fsvs6y	Physical Exercise associated with daily whey protein supplementation in the management of Type 2 Diabetes Mellitus in older adults	Recruitment completed	Intervention	2025-07-01	<NULL>	<NULL>	8089	Combined Training associated with Daily whey Protein Supplementation in the treatment of Type 2 Diabetes Mellitus in older adults: randomized triple-blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-10	Universidade São Judas Tadeu	Instituto de Ortopedia e Traumatologia do Hospital das Clínica da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fsvs6y	<NULL>	Elderly participants with type 2 diabetes mellitus; aged between 65 and 79 years; male; on a stable dose of medication (oral antidiabetics, insulin, or a combination of both) for three or more months; glycated hemoglobin between 6% and 10.0%; without renal function impairment, which will be assessed using the Modification of Diet in Renal Disease (MDRD) formula, including only those with values above 60 ml/min; without musculoskeletal system impairment, pain, or any disabling disease or previous surgeries that prevent exercise; without inadequately treated or decompensated chronic non-communicable diseases, especially systemic arterial hypertension; with cognitive function within the normal range; assessed by the MoCA; considering cutoff scores according to the participant&apos;s educational level	Inability to undergo assessments and reassessments; having more than three absences during the training period; experiencing any adverse events related to musculoskeletal pain or worsening of symptoms or signs of pre-existing diseases; particularly changes in systemic blood pressure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-34vg84w	The impact of exercise during hemodialysis in falls and fatigue in patients treated with hemodialysis	Recruiting	Intervention	2025-07-01	<NULL>	<NULL>	8090	The impact of Intradialytic Aerobic Exercise in incidence of falls and fatigue in patients treated with hemodialysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-34vg84w	<NULL>	Patients over 18 years old; of both genders; undergoing regular HD treatment for more than three months, at least twice a week; who are clinically stable; not engaged in regular and organized physical activity	myocardial infarction (in the last six weeks); patients with unstable angina; acute cerebrovascular disease; lower limb amputation above the ankle; patients unable to perform functional tests; patients with cognitive impairments that affect consent and participation in the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-8bhgyg8	Effect of a Laser protocol on Postoperative Pain reduction in Root Canal treatment: A Pragmatic Clinical Trial	Recruiting	Intervention	2025-07-01	<NULL>	<NULL>	8091	Effect of a Photobiomodulation protocol on the reduction of Postoperative pain in Endodontic Treatment: a pragmatic clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Faculdade de Odontologia da Universidade Federal do Amazonas	Universidade Federal do Amazonas (UFAM)	https://ensaiosclinicos.gov.br/rg/RBR-8bhgyg8	<NULL>	Competent adult patients; both genders; aged between 18 to 65 years; with referral for endodontic treatment in permanent teeth from public healthcare services with referral documentation; patients with contact number	Patients at any gestational stage; immunocompromised or with special needs; teeth presenting endodontic complications; teeth with calcifications; teeth with external or internal resorptions; incomplete root formation; teeth with dental perforations; teeth with longitudinal or vertical fractures; severe periodontal disease; teeth not completed in a single session	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-9mp2vsm	Performance evaluation of different approaches for alveolar bone preservation	Recruiting	Intervention	2025-07-01	<NULL>	<NULL>	8092	Impact of different approaches to alveolar bone preservation on healing and maintenance of bone volume, rehabilitation aesthetics, and patient perception	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Associação Unificada Paulista de Ensino Renovado Objetivo	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9mp2vsm	<NULL>	Patient aged between 18 and 80 years; both genders; indication for Extraction of a single-rooted tooth; subsequent installation of at least one dental implant; the reasons for Extraction may include the impossibility of restorations due to extensive Caries Lesions, Prosthetic Failures, Root Fractures, or Endodontic Failures; the region to receive implants must present bone dimensions that allow the future placement of the dental implant and adequate prosthetic space; at least three bone walls must be present	Heavy smokers individuals (more than 10 cigarettes per day); pregnant women; lactating women; uncompensated systemic diseases (Diabetes Mellitus, Osteoporosis, Immunological Disorders, Hepatitis, etc.); use of Corticosteroids, Non-steroidal Anti-inflammatory drugs, Immunosuppressive drugs, Estrogen and Estrogen Receptor Modulators, Bisphosphonates, and Calcitonin during the 6 months before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-6hxvph7	Effects of green tea kombucha on health and physical performance	Not yet recruiting	Intervention	2025-07-01	<NULL>	<NULL>	8093	Green tea kombucha with grape peel phenolic extract: sensory evaluation and the acute and chronic effects on health and physical performance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-11-20	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Departamento de Tecnologia de Alimentos da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-6hxvph7	<NULL>	Men and women; aged between 18 and 45 years; body mass index between 18.5 and 24.9 kg/m²; with low to moderate levels of physical activity, assessed by the International Physical Activity Questionnaire – short version (IPAQ)	Individuals with chronic diseases or disorders affecting the digestive, oral, hepatic, renal, cardiovascular, or thyroid systems; individuals with cancer; inflammatory diseases or eating disorders; those who have used anti-inflammatory drugs, corticosteroids, or antibiotics in the past three months; pregnant, breastfeeding, or menopausal women; individuals who use tobacco and/or drugs; those with alcohol consumption exceeding 21 units per week for men and 14 units per week for women; individuals undergoing nutritional counseling for muscle mass gain; those who use antioxidant nutritional supplements; individuals with present or recurrent musculoskeletal injuries; those who frequently consume Kombucha, other fermented foods, or green tea; individuals with an aversion to Kombucha	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-2gfrq29	Evaluation of the Implantation of a biomaterial in the form of a Biocellulose with Strontium Apatite membrane for preservation of the dental supporting bone margin: a randomized, double-masked study with patients	Recruiting	Intervention	2025-06-30	<NULL>	<NULL>	8078	Evaluation of a biocellulose with Strontium Apatite membrane for alveolar bone crestal preservation: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Estadual Vale do Acaraú	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2gfrq29	<NULL>	Spontaneous demand; screening between April and December 2025; signing of the free and informed consent form (FICF); adults between 20 and 40 years old; both sexes; all ethnicities; good systemic health; good oral hygiene; indication for premolar extraction due to trauma, endodontic complication or irreparable caries	Uncompensated diseases (hypertension, diabetes or coagulation disorder); pregnant and lactating women; smokers; irradiated; immunocompromised; users of antimicrobials or anti-inflammatories one month before the study; allergy to biomaterials or anesthetics; periapical lesions; need for ostectomy to complete the extraction; dehiscence or fenestrations observed during surgery; uncooperative patient during treatment or who does not return for reassessment (study withdrawal)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-8srwcqg	Implementation of a care program on falls prevention in older adults at high risk of falls	Not yet recruiting	Intervention	2025-06-30	<NULL>	<NULL>	8079	Implementation of a case management-based intervention focused on falls prevention in older adults at high risk of falls: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-15	Centro de Ciências Biológicas e da Saúde	Centro de Ciências Biológicas e da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8srwcqg	<NULL>	Level of consciousness that allows the volunteer to be an active subject in the intervention; both genders; aged over 60 yeas; high risk of falls according to the global recommendation for the prevention and management of falls in older people (older people with a history of at least 1 fall in the last year and one or more of the following characteristics: injurious fall; ≥2 falls in the last year; presence of frailty syndrome; inability to get up after a fall without help for at least one hour; and fall accompanied by suspected transient loss of consciousness); ability to walk alone with or without a walking aid); and willingness to participate in the proposed assessments and interventions	Severe and uncorrected hearing and visual impairment that makes communication difficult during the intervention; presenting neurological diseases that rapidly modify the risk of falls (multiple sclerosis; diagnosis of moderate to advanced dementia; epilepsy; and traumatic brain injury; or taking associated medications); and presenting some contraindication to physical exercise (acute infectious disease; dissecting aortic aneurysm; severe aortic stenosis; congestive heart failure/unstable angina; acute myocardial infarction; acute myocarditis; acute pulmonary or systemic embolism; thrombophlebitis; ventricular tachycardia; and other dangerous arrhythmias)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-106yjkc3	Application of Telecare technologies in patients with Temporomandibular Disorders and Bruxism	Recruiting	Intervention	2025-06-30	<NULL>	<NULL>	8081	Use of Teleassistance tools in the care of individuals with Temporomandibular Disorders and Bruxism	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Programa de Pós Graduação em Odontologia da Universidade Federal do Paraná	Setor de Ciências da Saúde da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-106yjkc3	<NULL>	Over eighteen years of age; both genders; any ethnicity; who contact the temporandibular disorder and orofacial pain service at the Federal University of Paraná	Minors under 18 years of age; participants who do not have time for the appointments at the University clinic at the scheduled times; psychological or mental abnormalities that may prevent collaboration and completion of the questionnaires; participants who do not have access to a smartphone with the WhatsApp application installed; people who have previously received a clinical assessment of temporomandibular disorder and orofacial pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-586qvsj	Nebulized BromAc as a therapy to treat respiratory diseases	Recruiting	Intervention	2025-06-30	<NULL>	<NULL>	8082	Safety and efficacy of BromAc in subjects with acute respiratory failure due to infections: a phase 2 study (BROM-RES)	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2025-06-20	Universidade Federal de Minas Gerais	Hospital das Clínicas - Faculdade de Medicina - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-586qvsj	<NULL>	The participant or responsible party understands the procedures and requirements and is willing, and capable of providing informed consent for full participation in the study. Adults, male or female. Aged between 18 and 85 years at the time of consent with community-acquired pneumonia under mechanical ventilation admitted to the ICU. SARS-CoV-2 positive by rapid antigen testing in the case of COVID patients. Reported symptoms of severe respiratory illness (including fever or history of fever). The responsible party agrees and can fulfill all study procedures, including availability and contact information for follow-up visits. Patients may be intubated for up to 48 hours. Additionally, patients must have a secretor profile with vigorous mucous production at a capacity of 2mL of mucous per aspiration	Contraindication, or known hypersensitivity reaction to any elements of the proposed therapy. Currently participating in another therapeutic trial. Pregnant women. Severe ventilatory and hemodynamic instability that precludes procedures for aspiration or administration of the study medication, as defined by the attending medical team. Severely immunocompromised patients: solid organ or bone marrow transplant recipients within the past year, HIV/AIDS with CD4+ &lt; 200 cells/mm3, severe neutropenia (&lt; 500 cells/mm3 or &lt; 1,000 cells/mm3 with a prospect of dropping below 500 cells within 48 hours), patients on corticosteroid pulse therapy (dose &gt; or = 250 mg of methylprednisolone or equivalent) or with another potent immunosuppressant (e.g., cyclophosphamide) in the last 28 days. Moribund participants or patients without a therapeutic proposal, with a prospect of death within the next 24 hours, as defined by the attending medical team	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-7hx5wsk	Caffeine gum: impact on male beach volleyball athletes&apos; performance	Recruitment completed	Intervention	2025-06-30	<NULL>	<NULL>	8083	Effects of caffeine chewing gum on the performance of male beach volleyball athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-15	Centro de Ciências da Saúde e do Esporte	Centro de Ciências da Saúde e do Esporte	https://ensaiosclinicos.gov.br/rg/RBR-7hx5wsk	<NULL>	Be at least 18 years of age; to be of the masculine gender; regularly training and competing at a professional level in beach volleyball for at least 2 years; being free from chronic diseases; self-report of not regularly using any substance that could interfere with metabolic responses; self-report of not regularly using any nutritional supplement containing intracellular buffers	Possess a physical limitation that makes them unable to jump or attack; engage in physical activity within 24 hours preceding the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-106bgs3c	Weight Loss in Obese Adults Using Sibutramine versus a Combination of Sibutramine and Topiramate	Recruitment completed	Intervention	2025-06-30	<NULL>	<NULL>	8084	Weight loss in adults with obesity using Sibutramine versus combination of Sibutramine and Topiramate	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-11-05	Irmandade da Santa Casa de Misericordia de São Paulo	Irmandade da Santa Casa de Misericordia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-106bgs3c	<NULL>	Participants aged between 18 and 64 years; both sexes; with a Body Mass Index - BMI greater than or equal to 30 kg/m² or a BMI greater than or equal to 27 with risk factors	Diagnosis of type 2 diabetes mellitus with one risk factor for cardiovascular disease; history of heart disease such as coronary artery disease, heart failure, tachycardia, peripheral arterial obstructive disease, arrhythmia, cerebrovascular disease, or uncontrolled hypertension (BP maior que 145 por 90 mmHg); renal or hepatic insufficiency; bulimia or anorexia; use of other antiobesity medications in the past 3 months; personal or family history of nephrolithiasis; pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-7f8rdnf	Effect of acute theacrine supplementation and exercise on mood, cognition, and health in young adults.	Recruiting	Intervention	2025-06-30	<NULL>	<NULL>	8085	Evaluation of the effect of acute theacrine supplementation associated with a physical exercise program on mood, mental health, cognition, and health parameters of young individuals.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-09	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-7f8rdnf	<NULL>	Adults aged between 18 and 45 years; individuals engaged in resistance training for at least six months prior to the first study visit, to avoid delayed-onset muscle soreness typically observed in untrained individuals; with or without a diagnosis of common mental disorders (anxiety and/or depression); of both sexes	Osteoarthritis and rheumatoid arthritis; human immunodeficiency virus (HIV) infection; musculoskeletal disorders that prevent physical exercise; hypertension (systolic blood pressure above 120 mmHg and/or diastolic blood pressure above 80 mmHg); cardiovascular diseases; pregnancy and lactation; use of anticonvulsants; use of central nervous system stimulants, such as methylphenidate (Ritalin®, Concerta®), lisdexamfetamine (Vyvanse®, Juvene®), bupropion hydrochloride (Wellbutrin XL®, Zetron XL®, Bup), lithium carbonate (Carbolithium®); smokers, due to the stimulant effect of nicotine on the central nervous system. All information will be collected through anamnesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-10hr8nzd	Evaluation of the safety, ease of use, effectiveness, and cost of three ways to fix feeding tubes in critically ill patients	Recruiting	Intervention	2025-06-30	<NULL>	<NULL>	8086	Safety, efficacy, usability, and cost-effectiveness of three nasogastric tube Fixation devices: A cluster-randomized, controlled, crossover clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-03-10	Empresa Brasileira de Servicos Hospitalares - Ebserh	Santa Casa de Campo Grande	https://ensaiosclinicos.gov.br/rg/RBR-10hr8nzd	<NULL>	Patients of both sexes (male and female); admitted to the adult intensive care units of the surveyed institutions; using a nasoenteric catheter; aged ≥ 18 years; with no pre-existing nasal mucocutaneous injury.	Patients allergic to fixation device materials; with systemic dermatological disease; using the nasoenteral catheter for less than 24 hours; with cutaneous abnormality at the fixation site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-2m7w87r	Effect of Protein and Carbohydrate Supplementation Associated with Resistance Exercise as a Treatment for Type 2 Diabetes Mellitus	Data analysis completed	Intervention	2025-06-30	<NULL>	<NULL>	8087	Effect of Protein and Carbohydrate Supplementation Associated with Resistance Exercise as an Adjunct in the Treatment of Type 2 Diabetes Mellitus: A Randomized, Triple-Blind Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-19	Universidade São Judas Tadeu	Faculdade de Medicina da  Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2m7w87r	<NULL>	Diabetes Mellitus type 2 (DMT2)  with a stable medication dose (oral antidiabetics, insulin, or a combination of both) for three or more months; glycated hemoglobin between 6% and 9.0%; renal function assessed by the Modification of Diet in Renal Disease (MDRD) above 60 ml/h; no untreated or decompensated chronic non-communicable disease; male sex; age between 65 and 79 years	Inability to undergo assessments and reassessments; having more than three absences during the training period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-9brv7dd	Analysis of the Oral Environment in patients treated with Laser Therapy for Oral Mucositis	Recruiting	Intervention	2025-06-28	<NULL>	<NULL>	8074	Analysis of the Oral Microbiome in patients treated with Photobiomodulation for Oral Mucositis	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2024-10-22	Hospital Erasto Gaertner	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9brv7dd	<NULL>	Patients with malignant neoplasms in the head and neck region; undergoing radiotherapy treatment; both genders; no minimum or maximum age limit	Patients undergoing chemotherapy; uncontrolled or severe periodontal disease; application of oral topical medication; use of systemic corticosteroids; anti-inflammatory therapy; patients with salivary gland tumors; surgical removal of major salivary glands	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-2y8jkqb	THYRI Project: Two-plane uterine suture to decrease myometrial dehiscence in the cesarean site.	Not yet recruiting	Intervention	2025-06-28	<NULL>	<NULL>	8075	THYRI Project: Two-Plane Hysterorrhaphy to Reduce Isthmocele	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-15	Faculdade de Medicina de Jundiaí	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2y8jkqb	<NULL>	Pregnant woman submitted to the first cesarean section; pregnant woman submitted to lower-segment transverse cesarean section; woman with singleton pregnancy; no minimum or maximum age limit; feminine gender	Pregnant woman with myoma in the segment region of the uterus; woman submitted to emergency/urgent c-sections; woman with placenta previa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-9sn5qgw	Study on the impact of educational activities using the dietary guidelines on the eating habits of high school students	Recruitment completed	Intervention	2025-06-28	<NULL>	<NULL>	8076	Educational intervention in a high school class: the impact of the brazilian dietary guidelines on students’ knowledge of food and nutrition	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Pontificia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9sn5qgw	<NULL>	Minimum age 10 years; maximum age 19 years; both genders; students who submitted the assent and consent forms signed by themselves and their legal guardians	Under 10 years old; over 19 years old; students who did not submit the assent and/or informed consent forms signed by themselves and their legal guardians	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-6kth487	The effect of Stepping Training with Visual Stimulation on older adults	Recruiting	Intervention	2025-06-28	<NULL>	<NULL>	8077	The effects of Integrated Visa-Motor Stepping Training on older adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6kth487	<NULL>	60 years of age or older; both genders; residing in Porto Alegre; being available to participate in the program on the specified days and times; being independent in basic activities of daily living, as determined by the Katz Index of Independence in Activities of Daily Living; and having signed the informed consent form for the study	To have physical limitations that prevent the execution of the proposed exercises; have any clinical condition that contraindicates physical exercise (such as coronary heart disease, venous thrombosis, or severe psychiatric disorders, etc.); have severe cognitive impairment (scoring below 12 on the Mini-Mental State Examination); or experience disabling pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-10j6jt6x	Physiotherapeutic Follow-up of Patients with Chronic Low Back Pain: Multidimensional Assessment and Use of Data from an Extension Project	Not yet recruiting	Observational	2025-06-27	<NULL>	<NULL>	8072	Use of the Extension Project Database: Multidimensional Assessment and Physiotherapeutic Follow-up of Patients with Chronic Low Back Pain in the Management of Physical, Functional, and Psychosocial Sequelae	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-07-01	Centro de Ciências Biológicas e da Saúde CCBS - Universidade Estadual do Oeste do Paraná	Centro de Ciências Biológicas e da Saúde CCBS - Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10j6jt6x	<NULL>	Volunteers with a clinical diagnosis of chronic low back pain; aged between 18 and 59 years; of both sexes; referred to the Physical Rehabilitation Center of the State University of Western Paraná (CRF-UNIOESTE), or by direct invitation	Individuals with acute low back pain; absence of safe hemodynamic conditions to perform the tests and worsening of chronic pain on the evaluation days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-4rzc3gk	Performance evaluation of peri-implant Mucositis treatment using Subgingival Polishing with Erythritol Powder	Recruiting	Intervention	2025-06-27	<NULL>	<NULL>	8073	Treatment of peri-implant Mucositis with Subgingival Polishing	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-02	Associação Unificada Paulista de Ensino Renovado Objetivo	Faculdade de Odontologia da Universidade Paulista (UNIP)	https://ensaiosclinicos.gov.br/rg/RBR-4rzc3gk	<NULL>	Patient aged between 18 and 80 years; both sexes; who have had dental implants in place for at least 12 months; diagnosis of peri-implant mucositis is made based on the presence of signs of peri-implant inflammation (redness, edema and bleeding 30 seconds after probing); absence of additional bone loss after initial healing (higher than 2mm)	Pregnant and lactating women; individuals with systemic diseases (osteoporosis, immunological disorders, hepatitis, diabetes mellitus); patients with active periodontitis and peri-implantitis; use of corticosteroids, non-steroidal anti-inflammatory drugs, immunosuppressive drugs, antibiotics, estrogen and estrogen receptor modulators, alentronate and calcitonin during the 6 months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-83h7hfm	Benefits of Nutrition and Physical Activity for the health of people with Kidney Issues	Recruiting	Observational	2025-06-26	<NULL>	<NULL>	8067	Impact of Nutrition and Exercise on Microbiota, Uremic Toxins and quality of Life in patients with Chronic Kidney Disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-11	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-83h7hfm	<NULL>	Volunteers diagnosed with chronic kidney disease; age minimum eighteen and age maximum sixty five years; physically inactive.	Smoker volunteers; diagnoses of cardic; gastrointestinal; hepatic; pulmonary; neurological; psychiatric; hematological or metabolic autoimmune diseases; diagnosis of sleep disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-7cggk36	Radiotherapy dose mapping for head and neck Cancer associated with treatment toxicities	Recruitment completed	Observational	2025-06-26	<NULL>	<NULL>	8068	Determination of dosimetric map from Intensity-modulated Radiotherapy for head and neck cancer and risk of associated toxicities	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-01	Santa Casa de Misericórdia da Bahia	Universidade Federal da Bahia (UFBA)	https://ensaiosclinicos.gov.br/rg/RBR-7cggk36	<NULL>	Patients with head and neck cancer that are expected to receive 50-70 Gy in the primary radiation field with a classic fractionation scheme into daily doses of 2-2.12 Gy (sessions held from Monday to Friday, with breaks on weekends) and curative intent, totaling 5 to 7 weeks of treatment; patients must have completed oral adaptation aimed at eliminating foci of dental infection; aged 18 years or older; of both sexes	Patients who do not receive a radiotherapy dose between 50-70Gy, non squamous cell cancer diagnosis, patients who, for some reason, are unable to complete the planned dental adjustment; or who do not meet the other inclusion criteria described; patients who do not sign the Informed Consent Form or who express a desire to be excluded from the study will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-3yyd4jd	Comparison of the effects of the Invisalign Palatal Expander (IPE) and the Hyrax Expander in the treatment of narrow maxilla	Not yet recruiting	Intervention	2025-06-26	<NULL>	<NULL>	8069	Effects of treatment of Maxillary Atresia in the mixed dentition with the Invisalign Palatal Expander (IPE) system and Hyrax expander: a randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade Anhaguera - UNIDERP	Universidade Anhaguera - UNIDERP	https://ensaiosclinicos.gov.br/rg/RBR-3yyd4jd	<NULL>	Ages 7 to 10 years; both sexes; Angle Class I malocclusion; presence of maxillary atresia; erupted upper and lower permanent incisors	Patients with craniofacial deformities; dental agenesis; history of previous orthopedic/orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-38gw93c	Effects of a maintenance program with different supervision frequencies in individuals with chronic respiratory disease	Recruiting	Intervention	2025-06-26	<NULL>	<NULL>	8070	Effects of a physical exercise maintenance program with different supervision frequencies in individuals with COPD: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-13	Universidade Federal de São Carlos	Departamento de Fisioterapia da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-38gw93c	<NULL>	Participants diagnosed with Chronic Obstructive Pulmonary Disease (COPD); who have completed, within the past month, a 12-week physical training program involving resistance and aerobic exercise, with or without behavioral change strategies; aged 50 years or older; of both sexes; who have been clinically stable for the past four weeks; undergoing medical follow-up with pharmacological treatment; who agree to participate in the study and have signed the informed consent form	Participants undergoing treatment for malignant neoplasms; with rheumatic, neuromuscular, orthopedic, or visual disorders that prevent physical training; with decompensated cardiovascular or respiratory diseases that hinder the performance of tests; and participants who choose to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-6ggm2pn	Awareness Raising Interventions in Schools: Education on aging and brain health for teachers	Recruitment completed	Intervention	2025-06-26	<NULL>	<NULL>	8071	EnvelheCiência	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6ggm2pn	<NULL>	All teachers and support staff from the two public schools and the adult literacy program in São Carlos; from both sexes	Refusal to sign the Free and Informed Consent Form - FICF	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-68qv6wf	Adaptation, usability and initial results of a mindfulness program to support people in the search for meaning in life in a study with comparison groups	Not yet recruiting	Intervention	2025-06-25	<NULL>	<NULL>	8065	Adaptation, feasibility, and preliminary effectiveness of a Mindfulness-based program (Mindfulness-based health promotion - mbhp) for the search for meaning in life: a randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-01-01	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-68qv6wf	<NULL>	General population aged 18 years or older (based on the Mindfulness-Based Health Promotion - MBHP protocol)	a) Participants in the acute phase of depression; bipolar disorder; psychotic disorders, especially those with severe symptoms; b) Participants at risk of or with a history of dissociation, post-traumatic stress disorder, personality disorder, epilepsy, etc.; c) Participants using medications that cause cognitive impairment; d) Those with evident cognitive impairment; e) Those without access to high-speed internet for online videoconferencing (computer or smartphone); f) Those who are not available to attend 8 online sessions, each lasting 2 hours, and are unable to commit to completing the prescribed home practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-1034tqgd	Effectiveness and safety evaluate of Covid-19 vaccines by the National Immunization Program: a multicenter cohort study in brazilian healthcare workers	Recruitment completed	Observational	2025-06-24	<NULL>	<NULL>	8064	Effectiveness and safety of Covid-19 vaccines by the National Immunization Program: a multicenter cohort study in healthcare workers	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-27	Empresa Brasileira de Serviços Hospitalares	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-1034tqgd	<NULL>	Healthcare workers; over the age of 18; both sexes; working in the public and/or private healthcare system in of Brazil	Individuals who had been vaccinated for COVID-19 in a clinical trial taking place in parallel at the research sites	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-57xv2xm	Comparison of the respiratory and analgesic effects of shoulder pain block in patients undergoing video shoulder surgery: a randomized clinical study	Recruiting	Intervention	2025-06-19	<NULL>	<NULL>	8061	Comparative randomized clinical study between brachial plexus block via interscalenic and costoclavicular via regarding respiratory and analgesic effects in patients undergoing shoulder arthroscopy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-57xv2xm	<NULL>	Age between 18 and 80 years, of both sexes, with an ASA score (American Society of Anesthesiologists) of 1 to 3, body mass index (BMI) between 20 and 35kg/m² undergoing elective arthroscopic shoulder surgery	Patients will be excluded from the study if they are unable to consent to the study, have neuropsychiatric diseases, cognitive impairment or altered mental status, pre-existing pulmonary disease (obstructive or restrictive), coagulopathy, sepsis, hepatic or renal failure (glomerular filtration rate less than 30ml/min), pregnancy, known or suspected allergy to medications used during anesthesia, chronic pain condition requiring the ingestion of opioids at home and previous surgery in the neck or infraclavicular region ipsilateral to the operated limb	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-5x3tfq3	Effect of Water Exercise on the heart of postmenopausal women with high blood pressure	Not yet recruiting	Intervention	2025-06-19	<NULL>	<NULL>	8062	Cardiovascular effects of Aquatic Training in hypertensive postmenopausal women: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-09	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Programa de Pós-Graduação em Ciências da Saúde da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5x3tfq3	<NULL>	Women; aged between 45 and 65 years; post-menopausal (1 year of permanent amenorrhea); who do not undergo hormone therapy; at most 6 years after menopause; hypertensive patients on medication; who have not practiced physical exercise regularly for at least three months, according to the response to physical activity practice obtained in the anamnesis; without musculoskeletal problems or cardiovascular complications that prevent the performance of physical exercise; must present a medical certificate proving that they are fit to practice physical exercise; have no history of stroke or acute myocardial infarction; are non-smokers and do not have a diagnosis of Diabetes Mellitus	Present any cardiovascular complications during collections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-8qqyf8k	Improving oral care in intensive care units patients: evaluation of the impact on hospital stay and survival rates: a clinical study	Recruiting	Intervention	2025-06-19	<NULL>	<NULL>	8063	Application of an oral hygiene protocol in patients admitted to intensive care units and association with length of stay and mortality rate: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-03	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8qqyf8k	<NULL>	Age 18 or over; Patients for whom it is possible to carry out the initial assessment within the first 24 hours of admission to the ICU; Patients for whom it is possible to reassess the oral condition every 48 hours; Patients for whom the ICU stay is longer than 48 hours; Patients of both genders	Traumas or fractures to the face or oral cavity that make clinical examinations and application of oral care protocols impossible; Management restrictions requested by the medical team	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:43
RBR-7ybw4gk	Use of physiotherapeutic monitoring data for Athletes and Para-Athletes	Recruiting	Intervention	2025-06-18	<NULL>	<NULL>	8059	Use of the Database of the extension project (mother project): preventive and recovery Physiotherapeutic Monitoring, with a focus on integrative biodynamics, for Healthy Athletes and Para-athletes	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Centro de Ciências Biológicas e da Saúde da Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7ybw4gk	<NULL>	Athletes of different levels and sports; of both sexes; aged over then 14 years	Not authorizing the use of their data for research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-10vj22fr	Combination of Laser Therapy and Phytotherapy for the Treatment of Menopausal Symptoms	Recruitment completed	Intervention	2025-06-18	<NULL>	<NULL>	8060	The use of standardized extracts of Angelica keiskei and Panax ginseng as a strategy to potentiate the biological effects induced by red laser on postmenopausal symptoms	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-05-05	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-10vj22fr	<NULL>	Women between 40 and 65 years of age; experiencing amenorrhea for at least 12 months due to natural causes or due to health treatment; characterizing the post-menopausal period	Participants who do not sign the informed consent form; women who have received hormone therapy in the last 6 months; with untreated hypothyroidism; any type of cancer; photosensitivity; cardiac arrhythmias; pacemaker wearers; presence of neurological; renal; hepatic diseases or infectious disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-2rtpqt8	The use of Alpinia zerumbet gel-cream to manage pain and symptoms related to temporomandibular disorders	Not yet recruiting	Intervention	2025-06-17	<NULL>	<NULL>	8058	Clinical evaluation of the use of alpinia zerumbet gel-cream for use in patients with muscle temporomandibular dysfunction: randomized clinical study	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-09-01	Universidade Federal de Sergipe	Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2rtpqt8	<NULL>	Individuals of both sexes; aged between 18 and 70 years; with at least 20 natural dental elements (10 on each side); diagnosed with muscular type temporomandibular disorders (TMD)	Individuals with any inability to answer questions asked during care; patients who are already using therapeutic ultrasound or another type of therapy for muscle fatigue	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-293yfsj	Complete Dentures Obtained by Three-Dimensional Printing Compared to the Conventional Technique – Clinical, Crossover, Randomized and Controlled Study	Recruiting	Intervention	2025-06-16	<NULL>	<NULL>	8055	Complete Dentures obtained by Additive Manufacturing compared to Conventional Manufacturing – Clinical crossover, randomized and controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-19	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-293yfsj	<NULL>	Individuals aged 45 years or older; of both genders; completely edentulous for at least 1 year; mentally receptive; with good understanding of spoken Portuguese; with normal unstimulated saliva flow (0.3 mL/min); without Denture-Related Stomatitis; presenting satisfactory or good ridges, according to the Kapur Index	Individuals with disorders of the stomatognathic system; with pathological alterations of the ridges or seat tissues of the prostheses; debilitating systemic conditions such as Decompensated Diabetes Mellitus, Chronic Kidney Disease, Chronic Obstructive Pulmonary Disease, Heart Failure, Advanced Liver Disease and malignant tumors; autoimmune diseases such as Systemic Lupus Erythematosus or Multiple Sclerosis; HIV/AIDS and malnutrition; self-reported pain; motor and cognitive disorders; use of antibiotics in the 3 weeks prior to recruitment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-8sg9x52	Attention, memory and quality of life in post COVID-19 adults	Recruiting	Intervention	2025-06-16	<NULL>	<NULL>	8056	Attention, memory, self-reflection and insight, and quality of life in post COVID-19 adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-02	Programa de Pós-graduação em Psicologia da Universidade Federal do Espírito Santo - Campus Goiabeiras	Instituto de Ensino e Pesquisa Alberto Santos Dumont	https://ensaiosclinicos.gov.br/rg/RBR-8sg9x52	<NULL>	healthy volunteers; volunteers with cognitive impairment associated with post-COVID syndrome; both genders; aged over 18 and under 60 years; not using psychoactive substances that affect memory, such as benzodiazepines and hypnotics; no history of neurological and/or psychiatric disorders before or after COVID-19; provide authorization to participate in the study by signing the Informed Consent Form	be under 18 years old and over 60 years old; use psychoactive substances that affect attention and memory; present physical or cognitive repercussions resulting from other diagnoses prior to or subsequent to COVID-19; present a history of attention and memory impairment prior to the diagnosis of COVID-19	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-4yrxxmy	Evaluation of the Influence of Cardiovascular Medication use on the Procurement of Autologous Blood Derived Membranes	Recruitment completed	Intervention	2025-06-16	<NULL>	<NULL>	8057	Clinical and Laboratory Assessment of Fibrin Membrane in patients with Chronic Diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-12-10	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-4yrxxmy	<NULL>	For the control group, healthy volunteers will be selected; classified as ASA 1 by the American Society of Anesthesiologists; of both genders; non-smokers; aged between 18 and 85 years; and with no recent history of using any type of medication. For the experimental group, cardiac patients who are regularly using anticoagulants will be selected	Patients with more than one disease; drug users; or who do not fit into the groups described above will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-88f3459	General versus regional Anesthesia complications	Not yet recruiting	Intervention	2025-06-15	<NULL>	<NULL>	8054	Impact of General versus Regional Anesthesia on the incidence of postoperative pulmonary complications in peripheral arterial surgery: a multicenter randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-07-15	Hospital de Clínicas de Porto Alegre	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-88f3459	<NULL>	Adult patients; men or women; American Society of Anesthesiologists classification II to IV;  aged &gt;18 years; scheduled for elective arterial revascularization surgery in the lower limbs	Patientes with a body mass index above 40 kg/m2;  those undergoing emergency surgery; with a history of lung surgery; persistent hemodynamic instability in the preoperative period; a history of asthma or chronic use of corticosteroid therapy; neuromuscular disorders; history of use of anticoagulants or antiplatelet agents in the preoperative period; other conditions that contraindicate spinal anesthesia will also be excluded from the study; patient refusal; infection at the puncture site for subarachnoid block; increased intracranial pressure; inability of the patient to cooperate due to agitation; cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-6zm7yvg	Effects of meals without or rich in ultra-processed foods and with low or high caloric density on spontaneous food consumption, motivation and exercise tolerance in healthy adults	Recruiting	Intervention	2025-06-13	<NULL>	<NULL>	8049	Effects of meals without or rich in ultra-processed foods and with low or high energy density on ad libitum energy intake, motivation and tolerance to acute physical exercise in healthy adults: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-24	Faculdade de Nutrição - Universidade Federal de Alagoas	Faculdade de Nutrição - Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-6zm7yvg	<NULL>	Age between 19 and 30 years; both sexes, body mass index between 18.5 and 24.9 kg/m²; classified as irregularly active or active according to the criteria of the International Physical Activity Questionnaire short version; stable weight for at least 1 month; willing to comply with the schedule proposed by the research	The need for medical clearance to exercise according to the American College of Sports Medicine&apos;s Exercise pre-participation health screening questionnaire for exercise professionals; self-reported diagnosis of cardiorespiratory problems; chronic use of any medication (eg. : anti-diabetics, anti-hypertensives, anti-depressants, anti-retrovirals, immunosuppressants); altered fasting blood glucose, blood pressure or lipid profile; condition that makes it impossible to perform anthropometry, measurement of energy expenditure components or ergometric tests; individuals who are unable to consume the diet provided and/or have any food intolerances/allergies/restrictions; disordered eating behavior assessed using the Three-Factor Eating Questionnaire-18 tool; smokers; pregnant and breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-1024tnxh	Laser treatment of the perineum after vaginal delivery	Recruiting	Intervention	2025-06-13	<NULL>	<NULL>	8052	Photobiomodulation Treatment for Perineal Trauma: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-02	Universidade Federal de São Paulo	Hospital São Lucas	https://ensaiosclinicos.gov.br/rg/RBR-1024tnxh	<NULL>	Age between 18 and 45 years old. Full term vaginal birth. First pregnancy. Body Mass Index appropriate according to gestational age according to the body mass index classification by Atalah and collaborators	Smoking and alcoholism. Gestational diabetes mellitus, hypertensive syndromes or autoimmune diseases.  Postpartum hemorrhage. Bacterial infection or sexually transmitted disease. History of vulvar and vaginal surgery.  Previous history of gynecological câncer.  Presence of metallic implants in the pelvic region. Women with a recent history of urinary tract infection.  Neurological changes. Using corticosteroid therapy. Withdrawal from the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-9vv3djz	Optical versus Digital Flexible Ureteroscopy: a prospective randomized study	Terminated	Intervention	2025-06-13	<NULL>	<NULL>	8053	New era of Flexible Ureteroscopy: comparison between Digital vs. Optical Flexible Ureteroscope	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2019-02-02	Irmandade da Santa Casa de Misericórdia de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9vv3djz	<NULL>	One or more renal stones measuring up to 2cm; one or more stones in the proximal ureter measuring up to 2cm; age over 14 years; both sexes	Malformations that directly or indirectly involve the urinary tract; presence of infectious signs: Leukogram greater than 10 thousand or deviation above 8% band forms, presence of fever in the last 48 hours preceding the procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-5yf2zv5	Eating-related issues and body image in candidates for bariatric surgery	Recruitment completed	Observational	2025-06-12	<NULL>	<NULL>	8043	Eating disorders, food addiction, body image, and related factors among Individuals undergoing bariatric surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-04-20	Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5yf2zv5	<NULL>	Inclusion criteria will be individuals of both sexes; aged 20 years to 60 years old; with a body mass index (BMI) of 35 kg/m² or higher; regardless of the presence of obesity-related comorbidities	Exclusion criteria will include the presence of severe psychiatric disorders; genetic syndromes; active smoking; alcohol dependence or; substance abuse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-10hyxnbc	Physical training with step exercises and its effects on gait, cognition, and fall prevention in older adults.	Recruiting	Intervention	2025-06-12	<NULL>	<NULL>	8044	Effects of &quot;square-stepping exercise&quot; on cognitive function, functionality, and fall prevention in older adults.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Secretaria Municipal de Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-10hyxnbc	<NULL>	60 years of age or older; both genders; live in Porto Alegre; be available to participate in the program on the days and times established; be physically independent	To have any clinical condition that contraindicates physical exercise (such as coronary heart disease, venous thrombosis, or severe psychiatric disorders, etc.); severe cognitive impairment (Mini-Mental State Examination score below 12); disabling pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-3xbdyym	Effect of Ear Seeds associated with Exercise in people with Chronic Pain	Recruiting	Intervention	2025-06-12	<NULL>	<NULL>	8045	Additional effect of 8 weeks of Auriculotherapy associated with Exercise practice in people with Chronic Musculoskeletal Pain in primary health care: randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Prefeitura Municipal de Diamantina	https://ensaiosclinicos.gov.br/rg/RBR-3xbdyym	<NULL>	Primary Health Care users in the city of Diamantina-MG; both sexes; age between 18 and 65 years; nonspecific low back pain (pain between the lower margins of the ribs and the gluteal folds) (AIRAKSINEN et al., 2006); neck pain; osteoarthritis; pain lasting at least three months; pain intensity with a minimum score of 5 points on the numerical pain scale	Fibromyalgia; neoplasms; radiculopathies; active inflammatory diseases; previous fractures of the spine or lower limbs; previous surgery; other treatment for pain besides exercise in the last 3 months; presence of infection; inflammation or injury in the ear; allergy to microporous tape; use of opioid-type pain relief medications; contraindications for regular physical exercise; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-38y9xk6	Evaluation of a bioactive gel to control dental sensitivity in dental bleaching in adolescents	Not yet recruiting	Intervention	2025-06-12	<NULL>	<NULL>	8046	Evaluation of a bioactive gel to control dental sensitivity in dental bleaching in adolescents: double blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-24	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-38y9xk6	<NULL>	Good general and oral health (no need for surgery, endodontic, or periodontal treatment); both sexes; age between 12 and 16 years; at least six anterior upper teeth are free of active caries and endodontic treatment; if the anterior teeth have restorations, they must involve no more than 1/3 of the dental structure; canines (13, 23) must be A2 color or darker	Participants are undergoing orthodontic treatment; participants with dental prosthetics; severe tooth discoloration (such as tetracycline stains, fluorosis, or non-vital teeth)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-9qdpgtk	Retrospective clinical evaluation of patients with root fractures treated at the dental trauma clinic of Federal University of Uberlândia	Recruiting	Observational	2025-06-12	<NULL>	<NULL>	8047	Retrospective clinical evaluation of patients with root fractures treated at the dental trauma clinic of UFU	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Faculdade de Odontologia Universidade Federal de Uberlândia	Hospital Odontológico da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9qdpgtk	<NULL>	Patients who were treated at the Dento-alveolar Trauma Clinic of the Faculty of Dentistry of the Federal University of Uberlândia – FOUFU / Dental Hospital of the Federal University of Uberlândia - HOUFU, from 2004 to 2024, minimum age 6 years; both sexes	Patients with traumatized primary teeth; patients under 6 years old; patients who cannot attend follow-up appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-2qdn4xr	Relation among Synbiotics and Resistance Training in Type 2 Diabetes Mellitus	Recruitment completed	Intervention	2025-06-12	<NULL>	<NULL>	8048	Synbiotics and Resistance Training as adjuvants in the treatment of Type 2 Diabetes Mellitus: randomized triple blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-10	AMC Serviços Educacionais S/C Ltda	Laboratório do Estudo do Movimento (LEM) do Instituto de Ortopedia e Traumatologia (IOT) do Hospital das Clínicas (HC) da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2qdn4xr	<NULL>	Men; at least 60 years of age; have a diagnosis of Type 2 Diabetes Mellitus; have been under medical supervision with a stable dose of medication (oral antidiabetics or insulin or a combination of both) for three or more months; have glycated hemoglobin (HBA1c) between 6 and 9.0%; have no impairment of the musculoskeletal system such as pain and any type of disabling disease or previous surgeries; do not have a chronic non-communicable disease not specifically treated and decompensated; be vaccinated against COVID-19	Failure to complete assessments and reassessments; absence more than three times during the training period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-7vc36g7	Use of Auriculotherapy and Floral Therapy for anxiety and sleep in university students	Recruiting	Intervention	2025-06-10	<NULL>	<NULL>	8040	Use of Auriculotherapy and Floral Therapy in the management of anxiety and sleep quality in university students: crossover study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-30	Faculdade de Enfermagem da Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7vc36g7	<NULL>	students enrolled in an undergraduate course at the University of Campinas (UNICAMP), on the Campinas campus, in the interior of the state of São Paulo; over 18 years old; of any gender; with the Pittsburgh Sleep Quality Index (IQSP) &gt; 5 and anxiety classified as moderate, high or very high, according to the State-Trait Anxiety Inventory (STAI)	not be a student at Unicamp; undergo pharmacological treatment related to sleep disorders; routinely perform any of the PICs planned for the interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-4hqtjy6	Observation in simulation health care	Recruitment completed	Intervention	2025-06-10	<NULL>	<NULL>	8041	Observation in clinical simulation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-07	Faculdade de Enfermagem da Universidade Federal de Juiz de Fora	Prefeitura Municipal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4hqtjy6	<NULL>	Nurses of both genders; Nurses with aged 18 or over; Nurses from the Health Care Network of the municipality of Juiz de Fora; Nurses is enrolled in the extension course CicatrizARTE	Missing some step of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-65gns68	Efficacy of magnesium in patients with TMD: clinical trial	Recruiting	Intervention	2025-06-10	<NULL>	<NULL>	8042	Evaluation of the efficacy of magnesium in patients with Myofascial Temporomandibular Disorder: a triple-blind randomized clinical trial	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2024-01-01	Fundação Universidade de Pernambuco	Faculdade de Odontologia de Pernambuco (FOP/UPE)	https://ensaiosclinicos.gov.br/rg/RBR-65gns68	<NULL>	Participants aged between 18 and 31 years old; patients with myofascial Temporomandibular Disorder (TMD); patients without associated comorbidities; patients without a history of allergies; patients without a history of kidney or liver injury; patients who sign the free and informed consent form for the research; female and male patients	Patients with joint problems; patients using other medications to control pain; patients who use dietary supplements to increase sports performance; patients who refuse to participate in the research; patients presenting chronic pain; patients with severe pain who require other adjuvant therapies; patients with minimal pain, according to the visual analogue scale (VAS) &lt; 3; pregnant patients; hyperthyroidism; patients using antidepressants; cardiac patients; patients suffering from Glaucoma; patients who use alcoholic beverages during the treatment period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-4j8p3wq	Joint manipulation on lung and heart	Not yet recruiting	Intervention	2025-06-09	<NULL>	<NULL>	8039	Joint adjustment in the functions of the lungs and heart in post-COVID-19 patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Centro Universitário Augusto Motta	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-4j8p3wq	<NULL>	Not engage in any physical activity outside of that proposed in the experiment; not be pregnant or breastfeeding; be free of functional limitations that would interfere with the performance of the experimental conditions; be free of any condition that could influence the experimental procedures or the interpretation of the resulting data; not present with abnormal fluid accumulation (edema), particularly in the lower limbs; have no basilar artery impairment that would contraindicate cervical manipulations; include both sexes; aged between 19 and 44 years	Participants must report no history of neurological disorders; must not report any episodes of acute dizziness; and must not present with severe visual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-3dcrj98	Open prospective study evaluating TIMP (Tissue Inhibitor of Matrix Metalloproteinase) as a biomarker of Myocardial Fibrosis in patients diagnosed with Chagas Disease	Recruiting	Observational	2025-06-05	<NULL>	<NULL>	8037	Prospective, open cohort study to evaluate TIMP as a biomarker of Myocardial Fibrosis in Chagas Disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Pronto Socorro Cardiológico de Pernambuco Prof. Luiz Tavares - PROCAPE	Pronto Socorro Cardiológico de Pernambuco Prof. Luiz Tavares - PROCAPE	https://ensaiosclinicos.gov.br/rg/RBR-3dcrj98	<NULL>	Participants diagnosed with Chagas cardiomyopathy, with reactive serology by two different serological methods (indirect immunofluorescence, indirect hemagglutination, complement fixation, conventional ELISA and recombinant ELISA immunoassay), with and without left ventricular dysfunction, as determined by transthoracic echocardiography; age 18 years or older up to 80 years or younger; both sexes; provision of written, signed and dated Informed Consent Form	Individuals with Trypanosoma cruzi infection in the absence of clinical manifestations and signs of cardiac involvement as characterized by normal electrocardiogram, chest X-ray, and echocardiogram; history or current diagnosis of malignant neoplasia; chronic use of corticosteroids, anti-inflammatory drugs, or immunosuppressants; patients with pacemakers, implantable cardioverter-defibrillators (ICDs), cardiac resynchronization devices, metal clips for aneurysms, or other metallic implants that may contraindicate MRI; individuals with known coronary artery disease (CAD) (acute myocardial infarction, unstable angina, history of myocardial revascularization or angioplasty, and documented coronary obstruction by catheterization or coronary CT angiography); research participants who have participated in clinical trial protocols within the last 12 months, unless the investigator determines potential direct benefit (per CNS Resolution 251, August 7, 1997, Section III, Subitem J); alcohol and substance abuse (prior diagnosis according to DSM-V criteria); illicit drug use; any clinical condition that the investigating physician interprets as a risk to participant inclusion; claustrophobic participants unwilling to take the study-prescribed anxiolytic (Rivotril 0.25 mg); patients with tachyarrhythmia if decompensated at MRI time; pregnant or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-4skswkf	Ultrasound-guided puncture versus conventional puncture of arteriovenous fistula	Not yet recruiting	Intervention	2025-06-04	<NULL>	<NULL>	8035	Ultrasound guided cannulation versus standard cannulation in arteriovenous fistula access: pilot and feasibility study of a crossover clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Escola de Enfermagem de Ribeirão Preto	Fundação Santa Casa de Misericórdia de Franca	https://ensaiosclinicos.gov.br/rg/RBR-4skswkf	<NULL>	Adult patients aged between 18 and 80 years; with a native arteriovenous fistula; recently created and without any previous puncture	Patients who present an arteriovenous fistula outside the maturation period and using grafts (prostheses)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-7tmgb9b	Effect of Physical Exercise training on the level of body function, intensity of Back Pain, Depressive Symptoms and Ability to Breathe in Chronic Kidney Patients undergoing hemodialysis	Recruitment completed	Intervention	2025-06-03	<NULL>	<NULL>	8031	Effectiveness of Physical Exercise training on the level of functionality, intensity of Low Back Pain, Depressive Symptoms and Respiratory Capacity in Chronic Kidney Patients undergoing hemodialysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Faculdade Ciências Médicas de Minas Gerais	Faculdade Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7tmgb9b	<NULL>	Patients with Chronic Kidney Disease - CKD in stages 4 and 5 (Classification of the Brazilian Society of Nephrology), aged 18 years or older; both sexes;  who have been undergoing Hemodialysis - HD for more than three months and three times a week	Resistant and uncooperative patients, who do not have the cognitive conditions to respond to questionnaires and carry out assessments based on the criteria and cut-off points proposed by the Mini Mental State Examination (MMSE) and according to education; who present an unstable clinical condition; neurological diseases; and patients who complete 60% or less of the exercise protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-45vy5p3	How Home Exercises with online guidance can help elderly people with Neck Pain during the COVID-19 pandemic	Not yet recruiting	Intervention	2025-06-03	<NULL>	<NULL>	8032	Effects of Home-based Therapeutic Exercises via teleconsultation on Neck Pain complaints in elderly individuals during the COVID-19 pandemic	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Centro de Ciências da Saúde da Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-45vy5p3	<NULL>	Individuals aged 60 years or older; of both sexes; with complaints of chronic cervical pain; who are actively enrolled in Open University for the Third Age (UNATI) and the waiting list of the Physical Therapy School Clinic (CEFISIO); and who have access to the internet via a mobile phone, tablet, or computer	Candidates who have generalized chronic pain syndrome (fibromyalgia); neurological diseases; decompensated systemic diseases; presence of chronic postural deformities; have undergone surgery or have trauma in the cervical spine region; active cancer; severe vestibular diseases that increase the risk of falls; severe visual impairment; musculoskeletal and vascular pathologies that contraindicate the proposed exercises; a history of psychiatric disorders that may interfere with the data to be collected; currently undergoing physiotherapy treatment for cervical pain; use of opioid analgesics (e.g., morphine, tramadol, hydromorphone, fentanyl, and others) at the time of data collection or within the past three months; and those showing any cognitive impairment verified through cognitive screening during the triage process	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-64prprc	Oxigen maintenance after anesthesia: two nasal cannulas evaluation	Recruiting	Intervention	2025-06-03	<NULL>	<NULL>	8033	Apneic oxygenation after anesthetic induction: a randomized comparative study between high-flow and low-flow nasal cannula for oxygen supply	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-30	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-64prprc	<NULL>	Patients over 18 years of age of both genders; indicated for surgery requiring general anesthesia with endotracheal intubation; and invasive blood pressure, at Central Institute of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Patient refusal; difficulty understanding and signing the informed consent form; moderate or severe pneumopathy (forced expiratory volume in 1 second less than 80% of predicted) or previous use of oxygen support, including prior intubation or tracheostomy; hemodynamic instability; predictors of difficult airway, for both ventilation and intubation; intracranial hypertension; patients at risk of bronchoaspiration, predictors of full stomach or ultrasonographic image of the gastric antrum confirming a large amount of content or solid content; Body Mass Index above 30 (obesity); confirmed pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-6dcn292	Effects of infrared and red light therapy on leg pain in patients with mild to moderate Lipedema	Recruitment completed	Intervention	2025-06-03	<NULL>	<NULL>	8034	Effects of Phototherapy on lower limb pain in individuals with mild to moderate Lipedema	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Hospital da Bahia S/A - Assistência Médica e Hospitalar	Clínica Vascular Takayanagi	https://ensaiosclinicos.gov.br/rg/RBR-6dcn292	<NULL>	Female patients; patients with lipedema classified as mild to moderate; presence of pain in adipose tissue in the extremities; age between 18 and 70 years; patients able to understand and sign the informed consent form prior to undergoing photobiomodulation	Male patients; patients who do not sign the informed consent form; patients without pain in the extremities secondary to lipedema; patients using analgesics or anti-inflammatory drugs; pregnant patients; patients with infection or malignant lesions at the application site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-6pmkr5w	Evaluation of tooth whitening performed with 16% carbamide peroxide with or without very small hydroxyapatite particles	Recruitment completed	Intervention	2025-06-02	<NULL>	<NULL>	8029	Clinical evaluation of efficacy and sensitivity during home bleaching with 16% Carbamide Peroxide added with Hydroxyapatite nanoparticles	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-05	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6pmkr5w	<NULL>	Those individuals who have anterior teeth free of carious lesions and without restorations on the buccal and palatal surfaces will be included in the clinical trial; who do not present tooth sensitivity (sensitivity stimulated with an air syringe); patients from 18 to 50 years old; patients with any kind of color (VITA color guide); patients who were able to read and sign the consent form and are willing to attend follow-up visits	Patients with systemic diseases; whitening performed six months ago or less; patients who underwent scaling less than 6 months ago; those allergic to peroxide; those with neoplasia; patients with dentin sensitivity equal to or greater than mild; teeth with severe internal discoloration (tetracycline stains, fluorosis or teeth without pulp); patients with amelogenesis; patients with habits such as smoking, chewing toothpicks or with parafunctional habits; patients with periodontal disease or undergoing treatment for periodontal disease; patients who had non-carious cervical lesions or anterior teeth with exposed incisal dentin; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-7zmskk9	Noinvasive ventilation after extubation: a randomized clinical trial	Recruiting	Intervention	2025-06-02	<NULL>	<NULL>	8030	Clinical outcomes and adverse events of non-invasive ventilation use after extubation: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-7zmskk9	<NULL>	Over 18 years of age; both genders; intubated patients; more than 24 hours on an invasive ventilatory system; tolerate spontaneous breathing test with Tayre connected to oxygen therapy support; arterial blood gases in stable state	Pregnancy; existing spinal cord injury; neurodegenerative diseases; need for emergency intubation; cardiac or respiratory arrest; facial and cranial trauma or surgery; tracheostomy; recent oral gastric or esophageal surgery; upper gastrointestinal bleeding; excessive amount of respiratory secretions; uncooperative patient; presence of hearing and vision deficits; patient who does not tolerate the spontaneous breathing test and previous medical decision to limit therapeutic effort	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:17
RBR-24px5hf	Acute effects of Dry Needling applied to muscles of recreational street runners: a randomized clinical trial	Recruiting	Intervention	2025-05-29	<NULL>	<NULL>	8027	Acute effects of Dry Needling applied to trigger points in the gastrocnemius muscles of recreational street runners: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-28	Universidade do Estado do Pará	Secretaria Municipal de Esporte e Lazer de Castanhal	https://ensaiosclinicos.gov.br/rg/RBR-24px5hf	<NULL>	Adults aged 18 to 35 years old; of both sexes; who practice street running recreationally, twice a week, run at least 15 km per week; with a practice time of at least 3 months, in a non-professional manner without receiving remuneration or material incentives and/or sponsorships; who agree to participate in the research and sign the TCLE; have 1 to 3 latent tension points or myofascial triggers in each gastrocnemius which	Runners who undergo professional rehabilitation monitoring or with a physiotherapist during the research data collection; have some acute or chronic persistent Osteomyoarticular Injury in the last 3 months; have serious health changes or bleeding disorders; fibromyalgia; pregnant women; autoimmune disease; iron deficiency; hypothyroidism; use lower limb prosthesis; people with fear of needles; have performed Dry Needling or acupuncture 4 weeks before; using anticoagulants; analgesic medications in the last 24 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-10yfb37g	Scalp Injections of Dutasteride 0,1% versus Placebo for treatment of Male Baldness	Recruiting	Intervention	2025-05-27	<NULL>	<NULL>	8024	Mesotherapy with Dutasteride 0,1% versus Placebo for treatment of Male Androgenetic Alopecia: randomized clinic trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-03-01	Departamento de Dermatologia e Radioterapia da Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-10yfb37g	<NULL>	Males; 25 and 50 years old; diagnosed with Androgenetic Alopecia classified on the Norwood Hamilton scale as 3V, 4 or 5; only those who sign the informed consent form will take part in the study	Patients who present any other causes of hair thinning other than Androgenetic Alopecia; known sensitivity to Dutasteride; diagnosis of previous Erectile Dysfunction; use of therapy to increase hair density in the last four months or previous Hair Transplant at any time; patients with insulin-dependent Diabetes Mellitus; history of Stroke; Cancer; thromboembolic phenomena; use of anticoagulant medications; Psoriasis; Lichen planus; use of exogenous Testosterone or other androgenic anabolic steroids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-33dd28c	Local use of Gentamicin for prevention of infections in cardiac pacemaker implants	Recruitment completed	Intervention	2025-05-27	<NULL>	<NULL>	8025	Local use of prophylactic Gentamicin in cardiac pacemaker implants	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-08-15	Centro Universitário Católico Salesiano Auxilium	Centro Universitário Católico Salesiano Auxilium	https://ensaiosclinicos.gov.br/rg/RBR-33dd28c	<NULL>	Adults aged 18 or over; both genders; treated at the Santa Casa de Misericórdia Public Hospital, in the city of Araçatuba; planning for insertion and/or replacement of a Cardiac Pacemaker	Non-consent to participate in the study; known allergy to Gentamicin; patients on Hemodialysis or Peritoneal Dialysis; history of previous heart transplantation; previous infection in implantable cardiac devices; previous infection with another prosthetic device; endovascular infection, including Endocarditis in the last 12 months; physical, clinical or laboratory signs or symptoms consistent with active infection; including but not limited to Pneumonia; urinary tract infection; cellulitis or bacteremia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-6bwn664	The use of audiovisual material in reducing dental fear/anxiety in children	Recruitment completed	Intervention	2025-05-27	<NULL>	<NULL>	8026	The use of positive pre-visit imagery audiovisual material as a strategy to reduce dental fear/anxiety in children treated at a school dental clinic: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-27	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-6bwn664	<NULL>	Children aged 4 to 10 years; children of both genders; children attending their first appointment at the School of Dentistry of the Federal University of Pelotas	Children with intellectual disabilities; caregivers with intellectual disabilities; children with visual impairments; caregivers with visual impairments; children with hearing impairments; caregivers with hearing impairments; absence from appointments after a 15-day interval	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-8phx8f5	Influence of melatonin on physiological responses and physical performance during and after running	Not yet recruiting	Intervention	2025-05-26	<NULL>	<NULL>	8016	Effect of acute melatonin administration on physiological parameters and physical performance during and after running under different conditions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Federal de São Carlos	Laboratório de Fisiologia Endócrina e Exercício Físico	https://ensaiosclinicos.gov.br/rg/RBR-8phx8f5	<NULL>	The sample will consist of male and female runners; aged between 18 and 35 years; who are apparently healthy; physically independent; asymptomatic; normotensive; non-obese (body mass index lower than 30 kilograms per square meter and body fat percentage lower than 20%); non-users of tobacco or alcohol; moderately active (engaging in at least 150 minutes of physical activity per week, preferably running); and regularly participating in running programs	Volunteers who self-report the following conditions will be excluded: cardiovascular diseases; metabolic disorders; sleep disturbances; musculoskeletal injuries or any neuromuscular disorders affecting the lower limbs that would impair participation; use of dermatological medications (for example, creams, ointments, and lotions); antipyretics or diuretics and/or use of ergogenic substances (for example, anabolic-androgenic steroids) within the six months prior to the study. Due to the potential influence of subcutaneous fat on the signals obtained through near-infrared spectroscopy, individuals with skinfold thickness greater than 20 millimeters in the regions of interest will also be excluded from the sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-6j752hm	Cervical manipulation and muscle and brain responses	Not yet recruiting	Intervention	2025-05-26	<NULL>	<NULL>	8017	The effect of upper cervical manipulation in physically active adults	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-01	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-6j752hm	<NULL>	Healthy male volunteers aged between 18 and 50 years; no functional limitations or medical conditions that could compromise their health or confound the study results; no abnormal fluid accumulation (edema), particularly in the lower limbs; no evidence of basilar artery impairment that would contraindicate cervical spinal manipulations	Not currently pregnant or breastfeeding; no self-reported history of neurological disorders; no reports of acute dizziness episodes; no severe visual impairments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-10j2h569	Main causes of dental implant failure	Recruitment completed	Observational	2025-05-26	<NULL>	<NULL>	8019	Dental implant failure is a multifactorial complication	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-10j2h569	<NULL>	Patients with complete medical records; who underwent the dental implant installation procedure between February 2022 and December 2024; of both sexes; minimum age 18 years	Patients with incomplete records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-6v9q8ft	Efficacy of Anesthetic Eye Drops for Oral Anesthesia in children: a clinical study	Not yet recruiting	Intervention	2025-05-26	<NULL>	<NULL>	8020	Efficacy of Ophthalmic Anesthetic for topical use in pediatric dentistry: randomized controlled clinical trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-6v9q8ft	<NULL>	Healthy children; of both sexes; aged between 8 and 12 years; who require dental procedures with infiltration anesthesia in the posterior region of the maxilla; treated at the pediatric dentistry outpatient clinic of the Federal University of Piauí	Patients who are feeling pain at the time of the clinical examination; with a history of allergy to benzocaine or oxybuprocaine; who have used analgesics or anti-inflammatories up to 24 hours before the procedure; with syndromes or behavioral changes; those whose parents/guardians do not authorize participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-4yn9vmm	Efficacy of laser treatment for obstructive sleep apnea - clinical trial	Not yet recruiting	Intervention	2025-05-26	<NULL>	<NULL>	8023	Efficacy of non-ablative treatment with combination of Nd:YAG and Er:YAG lasers for sleep-disordered breathing analyzed by clinical and molecular parameters - controlled, randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-15	Faculdade de Odontologia da Universidade de São Paulo	Sistema Nacional de Laboratórios de Fotônica	https://ensaiosclinicos.gov.br/rg/RBR-4yn9vmm	<NULL>	Men and women; aged between 25 and 65 years; regardless of race or social class; who are at risk of obstructive sleep apnea by screening with the Stopbang questionnaire; with a minimum wash out of six months for other therapies for sleep-disordered breathing; who agree to participate in the study with signature of the free and informed consent form	Undergoing medical treatment or treatment for sleep-related breathing disorders; smokers; alcoholics; cancer patients; with diagnosed lung problems; with heart disease; using more than two antihypertensive drugs; with pharyngeal or nasal obstructions that require strictly surgical resolution; with previous surgery in the oropharynx region; pregnant or lactating women; history of photosensitivity (allergies); using photosensitive medication; Body mass index (BMI) above 40 kg/m2; participants who are unable to attend treatment sessions or follow-up appointments; or who do not perform follow-up exams as indicated by the researchers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-78n85q8	Effect of ozone therapy as a complementary treatment for inflamed gums in people with or without diabetes – clinical study	Recruiting	Intervention	2025-05-25	<NULL>	<NULL>	8015	Effect of adjunctive ozone therapy to non-surgical periodontal treatment on clinical, microbiological, and immunological parameters in individuals with periodontitis associated or not with diabetes mellitus type 2 – a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Departamento de Odontologia - Faculdade de Ciências da Saúde - UNB	Departamento de Odontologia - Faculdade de Ciências da Saúde - UNB	https://ensaiosclinicos.gov.br/rg/RBR-78n85q8	<NULL>	Women, men, and all gender identities and sexual orientations. Diagnosis of stage III or IV periodontitis, defined as a chronic multifactorial inflammatory disease associated with a dysbiotic biofilm and characterized by the progressive destruction of the dental attachment apparatus. The diagnostic criteria for stage III or IV include interproximal attachment loss of 5 mm or more at the worst site or radiographic bone loss extending to the middle or apical third of the root, according to the 2018 classification of periodontal and peri-implant diseases and conditions. Presence of at least 10% of sites with bleeding on periodontal probing. Presence of at least two sites with probing depth ≥ 5 mm and bleeding on probing. Diagnosis of type 2 diabetes mellitus, with HbA1c ≥ 6.5%. Treatment for diabetes mellitus with hypoglycemic medications and/or insulin	Periodontal treatment in the last 6 months. Use of antimicrobial and immunomodulatory medications in the last three months. Presence of systemic conditions (other than type 2 diabetes mellitus) that interfere with periodontal status, including HIV, immune disorders, morbid obesity (BMI ≥ 40), or underweight (BMI ≤ 18.5). Pregnant or lactating individuals. Tobacco use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-4y2mmgd	Respiratory Muscle Training in children with Autism	Recruiting	Intervention	2025-05-23	<NULL>	<NULL>	8014	Respiratory Muscle Training in children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-26	Centro Integrado de Saúde Amaury de Medeiros - CISAM/ Universidade de Pernambuco	Centro Integrado de Saúde Amaury de Medeiros - CISAM/ Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4y2mmgd	<NULL>	Children with Autism Spectrum Disorder diagnosed; aged 6 to 19 years; of both sexes; with the ability to understand instructions used during training and testing	Individuals with associated neurological disease (e.g., cerebral palsy); use of tracheostomy; severe and/or chronic respiratory disease (pulmonary embolism, asthma); acute retinal detachment or recent eye surgery; severe and/or unstable heart disease; aneurysm of the aorta; recent surgeries or abdominal disease (last six months); as well as patients who present relevant bone or joint involvement of the lower limb that makes it impossible to perform the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-478xd66	Tests to prove the efficacy and safety of the Hycos Membraderm gel product in humans suffering from acute or chronic wounds in infected or non-infected lesions	Recruiting	Intervention	2025-05-22	<NULL>	<NULL>	8013	Single-blind study of efficacy and safety of the Hycos Membraderm gel product in humans	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-30	Nipo Serviços Médicos SS Ltda	Nipo Serviços Médicos SS Ltda	https://ensaiosclinicos.gov.br/rg/RBR-478xd66	<NULL>	Patients who are in the initial phase of treatment and have skin lesions resulting from wounds, cuts, bedsores and ulcers. Patients who have never undergone treatment and those who are already taking medication. Age between 18 and 90 years. Any ethnicity, color/race, phototype, and of both sexes	Pregnancy. Patients under 18 years of age. Sensitivity to product components	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-7x22s3g	Light-emitting diode in the prevention of radiodermatitis in the breast	Recruitment completed	Intervention	2025-05-20	<NULL>	<NULL>	8010	Use of LED in the prevention of radiodermatitis in breast cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Coordenação de Cursos de Pós-Graduação Lato Sensu e Extensão  da Escola de Saúde Pública do Distrito Federal (Fepecs)	Hospital de Base do Distrito Federal - Instituto de Gestão Estratégica de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-7x22s3g	<NULL>	women; over 18 years of age; with a histological diagnosis of breast cancer; undergoing conservative surgery or mastectomy; with or without reconstruction; scheduled for adjuvant radiotherapy; availability to attend before or after the radiotherapy session; sign the Free and Informed Consent Form (FICF)	mentally incapable of answering questions about their health;undergoing radiotherapy due to recurrence of the disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-6tg4myr	Effects of Square-Stepping Exercise in cognition, functioning and prevention of falls in elderly people with Parkinson&apos;s Disease	Recruiting	Intervention	2025-05-20	<NULL>	<NULL>	8011	Effects of Square-Stepping Exercise in cognitive function, functioning and prevention of falls in elderly people with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-15	Universidade Federal de Ciências da Saúde de Porto Alegre	Secretaria Municipal de Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6tg4myr	<NULL>	Be 60 years of age or older; both sexes; live in Porto Alegre; be available to participate in the program on the established days and times; having been diagnosed with Parkinson&apos;s disease, stages I, II or III, according to the Hoehn Yahr scale; have signed informed consent for the study	Have physical limitations that make it impossible to perform the proposed exercises; have any clinical condition that contraindicates physical exercise; suffer from severe cognitive impairment determined by a score less than12 on the Mini-Mental State Examination; disabling pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-2d2j5wp	A proposal for an ecological assessment of the affective response to increasing and decreasing intensity physical exercise in adolescents	Not yet recruiting	Intervention	2025-05-16	<NULL>	<NULL>	8007	The affective response to physical exercise of different intensities in adolescents	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-05-19	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2d2j5wp	<NULL>	Healthy volunteers; both genders; aged between 11 and 17 years; agree to participate in the study by signing the consent forms by their guardian and assent by the participant	Self-report of diagnosis of psychiatric disorders; self-report of use of alcohol or drugs; physical inability to perform physical exercise; participant who does not participate in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-69dym8p	Controlling symptoms in people with trigeminal nerve pain	Recruiting	Intervention	2025-05-16	<NULL>	<NULL>	8008	Controlling symptoms in people with Trigeminal Neuralgia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-17	Universidade Federal de Alfenas - Unifal	Casa de Caridade Nossa Senhora do Perpétuo Socorro - Santa Casa de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-69dym8p	<NULL>	Patients aged 18 years or older; regardless of gender; patients with trigeminal neuralgia (TN) who have not responded to the usual clinical treatment; who have not previously undergone any surgical procedure for the treatment of TN; who are physically and cognitively able to understand the Informed Consent Form and participate in the study by answering the instruments used	Patients who are delirious or mentally confused at the time of the approach; patients with psychiatric symptoms (psychosis, suicidal ideation, bipolar disorder); patients with an intense pain crisis that makes it impossible to respond to the study instruments; other personal and behavioral circumstances that would limit compliance with the study requirements, or judged by the doctor in charge to be incompatible with the possibility of participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-6y6yn52	Can a body intervention improve body image in pain in people with chronic musculoskeletal pain?	Recruiting	Intervention	2025-05-14	<NULL>	<NULL>	8003	The Influence of a perceptual intervention on body image and pain perception of people with chronic pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6y6yn52	<NULL>	The inclusion criteria will be: age 20 and over; being able to understand Portuguese to fill in the questionnaires; - being able to move independently with or without the use of aids; having chronic pain for at least 3 months; having a score ≥ 35 on the Central Sensitization Inventory (CSI); having chronic pain with a diffuse distribution (≥ 3 areas).	Exclusion criteria will be neurological comorbidities such as Parkinson&apos;s, epilepsy, stroke; predominantly neuropathic chronic pain mechanisms with loss of peripheral sensitivity, strength or radiating pain; or inflammatory rheumatological diseases such as rheumatoid arthritis, ankylosing spondylitis, psoriatic, systemic lupus erythematosus, Scheuermann&apos;s disease; subjects who have undergone cancer treatment in the last 6 months; conditions in which magnetic resonance imaging is contraindicated, such as asthma, unstable cardiac conditions, or the use of continuous medication that could interfere with the acquisition of images; individuals over 80 years of age (senior citizens).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-2fsnrrb	Chronic®: A Study to Strengthen Muscle Health in Patients with Sarcopenia	Not yet recruiting	Intervention	2025-05-14	<NULL>	<NULL>	8004	Evaluation of the efficacy and safety of chronic® nutraceutical on muscle mass and functionality in patients with sarcopenia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-07	Universidade Federal do Amapá	Hospital Universitário da Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-2fsnrrb	<NULL>	Individuals between 65 and 80 years old; With a SARC-CalF score &gt; or = 11 points, suggestive of sarcopenia (Barbosa-Silva et al, 2016); • Minimum score on the Mini Mental State Examination &gt; 24 points; • Capacity to consent: ability to provide written informed consent; • Medication stability: participants who are on a stable medication regimen (no changes in the last 4 weeks before the start of the study), if during the follow-up they require a substantial change in the medication regimen, the participant may be excluded.	Serious medical conditions: Individuals with serious medical conditions that could interfere with safe participation in the study or interpretation of the results, such as unstable heart disease, severe renal or hepatic impairment. Supplement use: Use of other nutraceutical supplements or changes in usual supplementation in the last 4 weeks before the start of the study. Neurological diseases that affect mobility or muscle strength. Active cancer: Patients diagnosed with active cancer or undergoing treatment for cancer in the last 5 years. Recent dietary changes: Significant changes in diet in the last 3 months. Participation in other studies: Participation in other clinical studies in the last 6 months. Individuals who perform intense physical activity or strength training regularly (more than 3 times per week) in the last three months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-5t96cx6	Auriculotherapy for Sexual Function in Menopausal women	Recruitment completed	Intervention	2025-05-14	<NULL>	<NULL>	8005	Auriculotherapy for Sexual Function in Climacteric women: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5t96cx6	<NULL>	The study will be developed with women between 40 and 65 years old, with a score less than or equal to 23 (which indicates the presence of FSD in women in menopause) in the Female Sexual Functioning Index (FSFI) scores, followed at the aforementioned UAPS Antonina Caeté Pedrosa in Mombaça, Ceará. The following inclusion criteria will be followed for sample selection: women between 40 and 65 years old; presenting cognitive capacity to respond to the variables of interest.	"Exclusion criteria will be: injuries or inflammation in the ear; allergy to micropore tape; pregnant women; presence of mental disorders that compromise the collection of variables of interest.
The criteria for discontinuation: participants who wished to stop their participation at any time during the research; presented reactions considered unpleasant related to the treatment; disagreed with the allocation of seeds in the protocol points; missed two or more sessions for any reason."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-5qczxhb	Coffee-flavored drink to shorten fasting time before surgery	Recruiting	Intervention	2025-05-13	<NULL>	<NULL>	8000	Instant coffee-flavored product to shorten pre-operative fasting	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Regional Integrada do Alto do Uruguai e das Missões – URI - Campus de Erechim	Universidade Regional Integrada do Alto do Uruguai e das Missões – URI - Campus de Erechim	https://ensaiosclinicos.gov.br/rg/RBR-5qczxhb	<NULL>	Volunteers who agree to participate in the study; aged between 18 and 65 years; of both sexes; undergoing elective surgery regardless of specialty or surgical team	Allergy to any component of the coffee-flavored instant product; pregnant women; individuals with diabetes; gastropathy; or gastroesophageal reflux will be excluded from the second phase of the study as part of the test group; there are no exclusion criteria for the control group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-24rgf7n	Outcomes of Alveolar Bone Grafting performed with chin or iliac crest associated with Platelet-rich Fibrin in patients with Complete Unilateral Cleft Lip and Palate	Recruiting	Intervention	2025-05-13	<NULL>	<NULL>	8001	Result of Alveolar Bone Grafts from chin or iliac crest associated with Platelet Rich Fibrin in patients with CLPUC	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-11	Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo	Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-24rgf7n	<NULL>	Alveolar bone grafting surgery performed by a single surgeon and using the mandibular symphysis or iliac crest as a donor area, associated or not with Platelet-Rich Fibrin (PRF); having Complete Unilateral Cleft Lip and Palate (CUCLP); without distinction of sex;  without distinction age	Presence of associated craniofacial syndromes and comorbidities, as well as diseases or use of medications that may influence the preparation of the Platelet-Rich Fibrin (PRF)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-7qtqwzf	The role of progressive overload in the development of strength and muscle mass	Recruitment completed	Intervention	2025-05-13	<NULL>	<NULL>	8002	Effect of overload progression of strength training on strength and muscle mass	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-07	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7qtqwzf	<NULL>	Healthy young adults aged 18 to 30; of both sexes; no previous experience in Resistance Training	Participants must not have engaged in resistance training during the six months prior to the study; they must not have any musculoskeletal injuries in the lower limbs or neuromuscular disorders that could interfere with the execution of the study protocols	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-83x2g2q	Multicomponent exercise in cognition and mood in older adults (VIVIFRAIL): How multicomponent exercises can influence the mind and emotional well-being of older adults?	Recruitment completed	Intervention	2025-05-12	<NULL>	<NULL>	7997	Long-term effect of multicomponent exercises adapted to the level of frailty on cognition and mood in older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-25	Pontifícia Universidade Católica do Rio Grande do Sul	Fundação de Assistência Social e Cidadania- FASC	https://ensaiosclinicos.gov.br/rg/RBR-83x2g2q	<NULL>	Older adults. Both genders. Aged 60 years or older. Regular attendance at the meetings of older adults’ groups supported by the Foundation for Social Assistance and Citizenship. No severe visual, auditory, or cognitive impairments that would prevent the safe performance of the proposed assessments or exercises	Participants with scheduled surgeries or medical procedures within the next eight months that would interfere with participation in the exercise program. Participants who, despite meeting eligibility criteria, are unable to remain seated without support for at least 10 minutes during the functional assessment. Participants who, during cognitive assessment, demonstrate an inability to comprehend or respond to verbal commands. History of acute myocardial infarction or unstable angina within the past 6 months. Report of uncontrolled atrial or ventricular arrhythmias within the past 30 days. Presence of dissecting aortic aneurysm. Severe aortic stenosis. Acute endocarditis or pericarditis. Uncontrolled arterial hypertension. Acute thromboembolic disease. Severe acute heart failure. Severe acute respiratory failure. Uncontrolled orthostatic hypotension. Diabetes mellitus with acute decompensation or uncontrolled hypoglycemia. Recent fracture within the past month. Any other clinical or functional condition that may be considered a contraindication or risk to engaging in physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-10g25ty6	Acute effects of Cognitive Tasks associated with aerobic physical exercise on a stationary bike on Brain Derived Neurotrofic Factor (BDNF) factor Blood Levels and on the cognitive performance in Elderly Participants	Recruiting	Intervention	2025-05-12	<NULL>	<NULL>	7998	Acute effects of the Dual Cognitive Task associated with Aerobic Physical Exercise on BDNF factor serum levels and Cognitive Performance in older adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Estadual De Londrina - UEL	Departamento De Educação Física Da Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-10g25ty6	<NULL>	60 or over. Both sexes. Physically independent. Normal cognitive status or with mild cognitive impairment. Not included in physical exercise programs	Use of medications antidepressants and beta blockers. Decompensated illness as  hypertension, arrhythmias, or other physical and/or psychological conditions that prevent them from participating in assessments and interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-89nqfrc	How nitrate intake, lack of nutrients, muscle strength, and mental function are related in cancer patients during chemotherapy: a study that tracks all of this over time	Recruiting	Observational	2025-05-12	<NULL>	<NULL>	7999	Nitrate intake, nutritional risk, muscle strength, and cognition in cancer patients undergoing chemotherapy: a prospective cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-05	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco (HC-UFPE)	https://ensaiosclinicos.gov.br/rg/RBR-89nqfrc	<NULL>	Female cancer patients; age between 18 and 59 years; undergoing chemotherapy; no previous oncological treatment; no use of enteral or parenteral diet	Patients affected by secondary tumors; patients included in the research, but who during the chemotherapy treatment needed to use other forms of adjuvant treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-845fvzs	Evaluation of the longevity of cone morse dental implants	Recruitment completed	Observational	2025-05-09	<NULL>	<NULL>	8134	Evaluation of the longevity of dental implants installed at the Integrated Clinic of the Universidade do Extremo Sul Catarinense	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade do Extremo Sul Catarinense	FGM Dental Group	https://ensaiosclinicos.gov.br/rg/RBR-845fvzs	<NULL>	Patients over the age of 18; both genders; with single or total Arcsys® implants; with a history of progress and imaging tests such as tomography and panoramic scans	Patients who cannot undergo imaging tests, such as pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-752fqvj	Evaluation of the effects of Three ways of Teaching Torrect Pelvic Floor Muscle Contraction in women: a randomized controlled clinical trial	Not yet recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7991	Evaluation of the effects of Intracavitary and Extracavitary Perineal Awareness in women: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2026-06-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-752fqvj	<NULL>	Women over 18 years of age; having had sexual intercourse with vaginal penetration	Not knowing how to read and not being able to answer the questionnaires; having a urinary tract infection; having purulent and yellowish vaginal discharge; having undergone previous pelvic radiotherapy; having neurological disease; having pain during vaginal penetration during sexual intercourse; knowing how to contract the pelvic floor correctly and not accepting to participate in the research and/or not signing the TCLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:16
RBR-8hknmnf	Evaluation of The Breath-holding time as a screening for the need to perform or not the Respiratory Function Test in the Preoperative Period of Abdominal Surgeries	Recruitment completed	Observational	2025-05-08	<NULL>	<NULL>	7992	Evaluation of The Apnea Test as a screening for the need to perform or not the Respiratory Function Test in the Preoperative Period of Abdominal Surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8hknmnf	<NULL>	over 18 years old	Pregnancy; cognitive impairment and behavioral disorders; use of bronchodilators in the 24 hours prior to the examination; use of stimulant or illicit drugs; use of Central Nervous System depressant drugs in the last 24 hours; painful or infectious symptoms that compromise the proper performance of the examination; hemoptysis; pneumothorax; cardiopulmonary instability; myocardial infarction or pulmonary embolism in the last 6 months; cerebral, thoracic or abdominal aneurysm; eye surgery in the last two months; previous thoracic surgery;  abdominal surgery in the last two months; use of continuous home oxygen therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-8pqgrpn	Assessment of the benefits of Health Education with educational material for patients with Parkinson&apos;s Disease	Recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7993	Assessment of the benefits of a validated educational manual for patients with mild to moderate Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-28	Hospital Universitário Walter Cantídio da Universidade Federal do Ceará	Hospital Universitário Walter Cantídio da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8pqgrpn	<NULL>	Have a diagnosis of Parkinson&apos;s disease according to the Movement Disorders Society criteria; Parkinson&apos;s disease stage from 1 to 3, according to the modified Hoehn and Yahr (HY) scale; be literate; Be ≥40 years old; female or male gender	Diagnosis of multiple sclerosis, acute disseminated encephalomyelitis, parkinsonism plus, cerebrovascular disease with motor sequelae, or Guillain-Barré syndrome; dementia syndrome of any etiology according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); schizophrenia with hospitalization, psychotic episode, or suicidal ideation in the last 6 months; Bipolar affective disorder with hospitalization or episode of mania, hypomania, or depression in the last 6 months; depression with hospitalization, suicidal ideation, or a psychotic episode in the last 6 months; myocardial infarction with or without ST-segment elevation in the last 12 months; myocardial revascularization surgery or percutaneous angioplasty in the last 12 months; uncontrolled arrhythmia; severe chronic obstructive pulmonary disease or oxygen dependency; Heart failure with functional reduction and symptom classification in stage III or IV; resting blood pressure ≥160 × 100 mmHg; implantable cardioverter-defibrillator; severe chronic kidney disease (creatinine clearance &lt;30 mg/dl); proliferative retinopathy due to type 2 diabetes mellitus; peripheral neuropathy with motor impairment; moderate to severe hearing impairment: inability to maintain a conversation or need for lip reading; moderate to severe visual impairment: minimum visual acuity of 20/70 on the Snellen scale; active cancer or undergoing cancer treatment; alcohol consumption &gt;14 drinks per week; living with individuals participating in the same study; thromboembolism without the use of anticoagulants; significant weight loss (10% of usual weight) in the last 6 months; lack of family support to participate in the study; mini-Mental State Examination (MMSE) score less than 25 for patients with 1 to 4 years of education, less than 27 for patients with 5 to 8 years of education, less than 28 for patients with 9 to 11 years of education, or less than 29 for patients with more than 11 years of education	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-536hkwg	Effects of Laser on pain and return of sexual function after postpartum Perineal Trauma: a feasibility study	Not yet recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7994	Effects of Photobiomodulation on pain and return of sexual function after obstetric spontaneous Perineal Laceration: a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital Universitário Cassiano Antonio Moraes (HUCAM) da Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-536hkwg	<NULL>	Postpartum women treated at the Maternity of Hospital Antônio Cassiano de Moraes (HUCAM); normal birth with spontaneous perineal laceration of any degree; Singleton pregnancy; aged 16 or over; completion of the free and informed consent form	Infectious disease; hemorrhoid; bruise or varicose veins in the perineum	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-4xc37tm	How the use of probiotics may help control the development of Periodontal Disease	Recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7995	Evaluation of the effect of a Probiotic on the progression of Periodontitis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4xc37tm	<NULL>	Being man or woman. Having stage III or IV periodontitis. Having received treatment for active periodontitis, including mechanical therapy with or without antibiotic therapy using amoxicillin and metronidazole, at the clinic of the School of Dentistry, University of São Paulo. Currently being in the supportive periodontal therapy phase. Being in good general health. Having at least six teeth present in the oral cavity, with at least one non-adjacent interproximal site presenting probing depth (PD) and clinical attachment level (CAL) equal to or greater than 5mm. Being over 18 years of age	Presenting any systemic condition that may influence the course of periodontal disease, such as diabetes, or that requires the use of systemic antibiotics. Being a smoker. Having a Body Mass Index (BMI) greater than 30 kilograms per square meter. Being pregnant or breastfeeding. Having used systemic antibiotics in the three months prior to the beginning of the study. Frequently using mouthwashes. Regularly consuming probiotic products. Being under 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-2m9r3j2	How consuming a yerba mate (ilex paraguariensis) extract can impact nutrition, metabolism, inflammation, and oxidative balance in overweight people	Not yet recruiting	Intervention	2025-05-08	<NULL>	<NULL>	7996	Effects of ingesting a yerba mate extract (ilex paraguariensis) on nutritional, metabolic, inflammatory parameters, and oxidative status in overweight individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-2m9r3j2	<NULL>	Men and women; age range between 40 and 65 years; without a history of cardiovascular disease; non-smokers or individuals who quit smoking in the past 3 years; individuals willing to maintain their usual diet and physical activity; individuals willing to maintain their habitual consumption of beverages rich in polyphenols (yerba mate, teas, coffee, wine, cocoa, soy milk, and fruit juices) during the study; individuals not using hypoglycemic, antihypertensive, or cholesterol-lowering medications; individuals who are overweight or obese (BMI ≥ 25 to 34 kg/m²); individuals who discontinued nutritional counseling at least 3 months ago or who are undergoing nutritional treatment but have not experienced weight changes &gt;5% in the last 3 months.	Diagnosis of uncontrolled metabolic or endocrine disorders; individuals who have undergone obesity surgery; postmenopausal women; pregnant and breastfeeding women; use of antipsychotics; those following vegetarian or vegan diets; individuals using probiotics or dietary supplements with antioxidant properties; those with weight fluctuations greater than 10% in the past three months; undergoing treatment for excess body weight (current low-calorie diet or nutritional treatment); smokers or chronic alcohol users; severe arterial hypertension, history of cardiovascular disease with clinical complications such as acute myocardial infarction and other coronary diseases; individuals with known malignant neoplasms, gastrointestinal diseases, kidney disease, and/or liver disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-3775776	Effects of Curcumin supplementation associated with resistance training on muscle gain, maximal strength, and blood markers in strength training practitioners: a randomized, double-blind clinical trial	Other	Intervention	2025-05-07	<NULL>	<NULL>	7989	Effects of Curcumin supplementation associated with resistance training on muscle hypertrophy, maximal strength, and biochemical biomarkers in strength training practitioners: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-21	União Brasileira de Educação e Assistência	União Brasileira de Educação e Assistência	https://ensaiosclinicos.gov.br/rg/RBR-3775776	<NULL>	Adult male bodybuilders; age 20 to 35; who have been bodybuilding for at least six months; practitioners who include at least three weightlifting physical activity sessions per week	Individuals diagnosed with any chronic disease or condition such as hypertension ; type 1 or type 2 diabetes mellitus ; as well as those using dietary supplements or medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-106nnmgg	Auriculotherapy for postpartum pain relief – a randomized clinical trial	Not yet recruiting	Intervention	2025-05-07	<NULL>	<NULL>	7990	Efficacy and acceptance of auriculotherapy for pain relief in the immediate postpartum period at the university hospital of Florianópolis - a pilot randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-29	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-106nnmgg	<NULL>	Vaginal delivery or cesarean section performed at Universitary Hospital (HU) of Universidade Federal de Santa Catarina (UFSC); age between 18 and 50 years; live newborn; agreement to participate in the study; sign the informed consent form	Severe medical complications in the postpartum period; history of severe psychiatric disorders or cognitive impairment; presence of piercings or similar items at the acupuncture point sites; contraindications for auricular acupuncture (infections at the application site, known allergies); additional surgeries or procedures (tubal ligation, hysterectomy)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-3jkk5c8	Role of Creatine supplementation in Elderly patients with Alzheimer&apos;s disease.	Recruiting	Intervention	2025-05-06	<NULL>	<NULL>	7984	Role of Creatine supplementation on metabolism, sarcopenia, functionality and cognition of Elderly patients with Alzheimer&apos;s disease: a randomized placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-16	Universidade Federal de Minas Gerais - UFMG	Instituto Nacional de Neurociência Translacional (INNT)	https://ensaiosclinicos.gov.br/rg/RBR-3jkk5c8	<NULL>	58 individuals (men and women); age equal to or over; Medical diagnosis of mild cognitive impairment or mild to moderate dementia due to or diagnosed with mixed dementia (from associated with cerebrovascular disease); Preserved ability to walk at least 10 meters without aid of gear devices and able to participate in the proposed interventions and evaluations.	Motor stroke motor sequelae; Other neurological diseases that affect cognition and/or mobility; functional limitation or sensory impairment; Parkinsonism; Some decompensated and/or renal cardiovascular condition - glomerular filtration rate (TFG) less than 40 ml/min/1.73 m2; presence of high microalbuminuria or proteinuria; diagnosed with type 1 diabetes mellitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-7d5bnmb	Vagus nerve stimulation in the auricular region for the treatment of patients with Temporomandibular Dysfunction – Pilot Study	Not yet recruiting	Intervention	2025-05-06	<NULL>	<NULL>	7985	Noninvasive Auricular Vagal Electrical Stimulation for the treatment of patients with Temporomandibular Dysfunction – Pilot Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-30	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-7d5bnmb	<NULL>	Adults aged 18 years or older; both sexes; diagnosis of temporomandibular dysfunction by the Diagnostic Criteria; completion of the free and informed consent form; change in heart rate variability with sympathetic or parasympathetic index outside the normal range (-1 to 1), in at least 2 of the 3 orthotest moments; minimum pain level of 4 considering an average of 4 values: greatest pain in the last week, least pain in the last week, average pain in the last week and current pain, all on a visual analogue scale from 0 to 10	Neurological impairment; rheumatological diseases such as rheumatoid arthritis and ankylosing spondylitis; cardiac arrhythmia or other cardiovascular conditions using beta-blockers; pregnant women or women who are breastfeeding; patients diagnosed with cancer; epilepsy; skull, cervical or rib fractures; severe osteoporosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-49hfhwk	Identification of psychological risk factors for the development of Professional Exhaustion Syndrome among anesthesia trainees: A prospective multicenter observational study	Recruiting	Observational	2025-05-06	<NULL>	<NULL>	7987	Identification of psychological risk factors for the development of Burnout among anesthesiology residents: A prospective multicenter observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-01	Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-49hfhwk	<NULL>	Anesthesiology resident physicians in their first, second and third year of specialization; from both sexes; with ages between 22 and 40 years; regularly enrolled in the Teaching and Training Center of the participating hospitals; who wish to participate in the study	Anesthesiology residents with a history of previously diagnosed mental disorders such as Bipolar Disorder; Schizophrenia; Major Depression; prior history of substance abuse; or other psychopathies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-7g7pv59	Medicinal plant spray to reduce tooth sensitivity after In-office Tooth Whitening	Recruiting	Intervention	2025-05-05	<NULL>	<NULL>	7981	Efficiency of a spray containing medicinal plants on Dentin Sensitivity after In-office Tooth whitening	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-15	Faculdade de Odontologia da Universidade Federal de Juiz de Fora	Faculdade de Odontologia da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7g7pv59	<NULL>	Individuals of both genders;  over 18 years or older; with a clinical indication for dental bleaching and without periodontal disease or dental caries	Participants reporting an allergy to hydrogen peroxide	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-3x9gb8s	Effects of body vibration combined with respiratory physiotherapy in patients with pulmonary emphysema and osteoporosis: a controlled clinical study	Not yet recruiting	Intervention	2025-05-05	<NULL>	<NULL>	7982	Evaluation of the efficacy and safety of a whole-body vibration protocol combined with pulmonary rehabilitation on the functional capacity and bone quality of patients with Chronic Obstructive Pulmonary Disease: a prospective randomized controlled single-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3x9gb8s	<NULL>	Sign the informed consent form thus authorizing their participation in the research; participants with a  diagnosis of Chronic Obstructive Pulmonary Disease; men or women; age over 45 years; they will need to walk without assistance or supervision from others even if they use some type of walking aid	Hypercalcemia; severe vitamin D deficiency (25-hydroxyvitamin D &lt; 12 nanograms per milliliter); uncompensated thyroid function disorders; creatinine clearance &lt; 45 milliliters per minute; recent history of hip fracture (&lt; 12 months); alcohol or illicit drug dependence; use of teriparatide; calcitonin; androgens; estrogens or selective estrogen receptor modulators in the past 6 months; use of bisphosphonates in the past 12 months; osteoarthritis with synovitis; use of osteoarticular prostheses; severe heart failure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-8skkj7q	Effect of Ibuprofen and Arginine gel on sensitivity after whitening: controlled clinical study	Recruitment completed	Intervention	2025-05-05	<NULL>	<NULL>	7983	Desensitizing action of topical application of Ibuprofen and Arginine gel on post-whitening sensitivity: a randomized, double-blind, split-mouth clinical study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-01-01	União Educacional de Cascavel	FGM Dental Group	https://ensaiosclinicos.gov.br/rg/RBR-8skkj7q	<NULL>	Patients of both sexes; aged between 18 and 30 years; presence of all vital anterior teeth; never having undergone dental whitening; not having restored anterior teeth; not having central incisor teeth with color A2 or darker	Patients with missing front teeth; with caries lesions; presence of gingival recession; with any restorative or prosthetic treatments; history of dental hypersensitivity; dental discoloration due to Tetracycline or Fluorosis; who use continuous medications such as anti-inflammatories and analgesics; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-1068g8pp	Study of magnetic brain stimulation and memory, attention, and reasoning in students	Recruiting	Intervention	2025-05-05	<NULL>	<NULL>	8431	Effect of Transcranial Magnetic Stimulation on cognitive performance in students	<NULL>	4, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Clínica Sinedor Ltda	Palm Serviços Médicos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-1068g8pp	<NULL>	Adults aged 18 to 80 years, of either sex; individuals without neurological comorbidities or with a clinical diagnosis of Parkinson’s disease or Alzheimer’s disease; ability to undergo the planned cognitive assessments and transcranial magnetic stimulation procedures; agreement to participate by signing the informed consent form, directly or through a legal representative when applicable	History of epilepsy or unprovoked seizures; severe or unstable clinical conditions that contraindicate participation in the study; contraindications to transcranial magnetic stimulation identified on clinical screening or according to device safety recommendations; inability to complete the proposed assessments or stimulation procedures; refusal to sign the informed consent form, directly or through a legal representative when applicable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:17
RBR-2dx9m4h	Change in grip strength induced by overflow contralateral to hip flexion	Data analysis completed	Intervention	2025-05-03	<NULL>	<NULL>	7980	Change in grip strength induced by overflow contralateral to hip flexion	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2dx9m4h	<NULL>	They were aged between 18 and 30 and had a motor preference for the right upper limb.	Volunteers with orthopaedic alterations, pain, difficulty in performing the palmar grasp and hip flexion movements, and failure to achieve at least 70 per cent of the maximum hip flexion force.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-4k29x2f	Effects of Bodybuilding Exercise performed at night on sleep in adults	Not yet recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7973	Effects of a Resistance Exercise session performed earlier versus later at night on sleep in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-10	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4k29x2f	<NULL>	Being between 20 and 55 years old; both sexes; doing resistance exercises more than 2 days a week	Cardiovascular, respiratory, osteoarticular diseases; use of medications; smoking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-5nfv46m	Innovation in health: analysis of physiological signals for the prevention and monitoring of Cardiovascular and Metabolic Diseases	Not yet recruiting	Observational	2025-04-30	<NULL>	<NULL>	7974	Geometric Analysis and Spectral Topology of Physiological Markers for preclinical indicators of Cardiovascular Diseases and Metabolic Syndrome in young and adult individuals	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-02	Centro Acadêmico de Vitória - Universidade Federal de Pernambuco	Centro Acadêmico de Vitória - Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5nfv46m	<NULL>	Adult individuals aged between 25 and 55 years old, of both genders, with preclinical or clinical diagnosis of cardiovascular disease (type 2 diabetes and hypertension), may present with comorbidities such as dyslipidemia or overweight and obesity. Control group – adult individuals aged between 25 years and 55 years old, of both genders, with no cardiovascular diagnosis	Individuals who are hospitalized or in the acute phase of the disease; who present any motor impairment; or who refuse to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-3bvgwq9	Auriculotherapy for stress and quality of students	Recruitment completed	Intervention	2025-04-30	<NULL>	<NULL>	7975	Effect of Auriculotherapy on quality of life and stress in undergraduate nursing students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-20	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-3bvgwq9	<NULL>	Students with active enrollment in the nursing degree at the Federal University of Espírito Santo; both sexes	Students on leave or with a suspension of enrollment; students who have started some drug treatment other integrative practice in the last 3 months; students pregnant up to 3 months; students with lesions in the pinna, injury or deformity in the ear; use of ear piercing (except for normal earrings); use of bilateral hearing aids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-10ht6b45	Treatment of joint pain after Chikungunya	Recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7976	Treatment of joint pain induced by Chikungunya infection	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Federal de São Paulo	Faculdade Sete Lagoas - FACSETE	https://ensaiosclinicos.gov.br/rg/RBR-10ht6b45	<NULL>	Patients proven to have been diagnosed with Chikungunya (serological test); Patients with more than 14 days of infection and who have joint pain (hands and feet); Patients aged between 25 and 80 years; of both sexes; with capacity that involves understanding the study and participation in the questionnaires applied; sign a Free and Informed Consent Form&quot;	Patients without laboratory confirmation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-8gxt823	Use of Calendula and Chamomile in the prevention and treatment of Skin Irritation caused by radiotherapy in patients with head and neck cancer: clinical study	Not yet recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7977	Use of Calendula and Chamomile in the prevention and treatment of Radiodermatitis in patients with head and neck cancer: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Liga Norteriograndense Contra o Câncer	Liga Norteriograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-8gxt823	<NULL>	Be 18 years of age or older; both sexes; have a histologically proven diagnosis of head and neck neoplasia with indication for radiotherapy treatment associated with chemotherapy; no previous history of antineoplastic treatment; no previous history of radiotherapy in the same field/treatment site; intact and continuous skin in the head and neck region on the first day of radiotherapy treatment	Interrupt oncological treatment for a period longer than eight days; use of any other type of product on the skin in the area undergoing radiotherapy treatment; have any type of allergy or hypersensitivity to EFA, calendula or chamomile	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-7qbb4bf	Evaluation of Caffeine and Sodium Bicarbonate in Athletes	Not yet recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7978	Evaluation of the Effects of Caffeine and Sodium Bicarbonate in Athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-21	Faculdade de Ciências da Saúde da Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7qbb4bf	<NULL>	Healthy volunteers; both genders; non-smokers; age between 18 and 40 years old	Smoking volunteers; history of alcohol or drug abuse; diagnosis of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-6vkwsjx	The effects of non-invasive cerebral electrical stimulation associated with cardiorespiratory training on blood pressure parameters, respiratory rate, functional capacity and muscle strength in sedentary individuals	Not yet recruiting	Intervention	2025-04-30	<NULL>	<NULL>	7979	Effects of tDCS associated with cardiorespiratory training on hemodynamic parameters, functional capacity and muscle strength in sedentary people: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-05	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6vkwsjx	<NULL>	Volunteers of both sexes; insufficiently active sedentary identified by global physical activity questionnaire; aged between 18 and 50 years	Volunteers active smokers; seizure history; pregnancy; signs of severity and/or indications for hospitalization; diagnosis of epilepsy or use of anticonvulsants; recent heart surgery (less than 3 months); unstable angina; clinical diagnosis of aneurysm; uncontrolled hypertension; metallic implants; tumor; previous brain surgery; important cranioencephalic anatomical alteration; chronic degenerative lower limb disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-5dz9yq8	Low-intensity Exercises during Chemotherapy infusion in women with Breast Cancer	Recruiting	Intervention	2025-04-29	<NULL>	<NULL>	7968	Low-intensity Exercises during Chemotherapy infusion for fatigue, functionality and neuropathy in women with Breast Cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-25	Hospital de Câncer de Barretos - Fundação Pio XII	Hospital de Câncer de Barretos - Fundação Pio XII	https://ensaiosclinicos.gov.br/rg/RBR-5dz9yq8	<NULL>	Women with histologically confirmed breast cancer; literate; scheduled to receive adjuvant or neoadjuvant chemotherapy; aged between 18 and 85 years; with a planned minimum of 5 cycles, after signing the Informed Consent Form - ICF	Patients who present any type of adverse reaction to exercise during the infusion; patients who report discomfort at any stage of the study and choose to withdraw the Informed Consent Term (ICT); patients who, for any clinical reason, need to interrupt chemotherapy treatment (toxicity, anaphylactic reaction, etc)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-73dm94r	Efficacy of Light Therapy in Temporomandibular Dysfunction in people with different skin tones: a clinical study	Not yet recruiting	Intervention	2025-04-29	<NULL>	<NULL>	7969	Effectiveness of Photobiomodulation Therapy on Temporomandibular Dysfunction in patients with different skin phototypes: a double-blind randomized controlled trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-73dm94r	<NULL>	Age between 18 and 55 years; female gender; presence of reported pain in the facial region lasting at least three months; and presence of a diagnosis of myofascial pain according to the evaluation criteria of the revised version of the Diagnostic Criteria for Temporomandibular Disorders - DC/TMD (Axis I, categories Ia and Ib)	Women who are receiving any treatment for Temporomandibular Disorders or accumulate simultaneous interventions outside of this protocol; have a history of tumor, trauma or head and neck surgery; a previous diagnosis of fibromyalgia or other painful musculoskeletal syndromes; neurological and psychiatric disorders; use of anxiolytics, antidepressants and anticonvulsants; or who are pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-3p52g2p	Effects of an Educational Intervention to change the lifestyle of people at risk for diabetes	Recruitment completed	Intervention	2025-04-29	<NULL>	<NULL>	7970	Effects of an Educational Intervention on anthropometric, biochemical, dietary and lifestyle parameters in individuals at high risk for type 2 Diabetes Melitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-20	Universidade Federal de Pernambuco (UFPE)	Universidade Federal de Pernambuco (UFPE)	https://ensaiosclinicos.gov.br/rg/RBR-3p52g2p	<NULL>	Individuals ≥ 20 years and &lt; 60 years; Not having a previous diagnosis of type 1 or type 2 DM; Displaying a body mass index (BMI) ≥ 25 and ≤ 34.9 kg/m², that is, overweight and grade 1 obesity; Having access to a WhatsApp application; Having access to the internet and a personal cell phone; Having a diagnosis of pre-diabetes or gestational diabetes (past) or a score equal to or greater than five in the Diabetes Risk Screening proposed by the American Diabetes Association – ADA	Pregnant women; People with diabetes mellitus, of any type; Unable to practice physical activity, as per medical advice; People with serious neurological or psychiatric problems; People with neoplasms, chronic transmissible diseases, liver or kidney failure, untreated thyroid dysfunction, congestive heart failure and coronary artery disease; Use of anti-obesity medication and/or oral antidiabetic medication; protein supplementation and use of hormone therapy; Have participated in a concomitant weight control program or a medically prescribed diet; Have undergone bariatric surgery in the last three years, or are planning to undergo surgery in the next 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-10dnk8pg	Effect of Polydextrose consumption on the composition of intestinal bacteria and blood sugar control in patients with Gestational Diabetes Mellitus	Recruiting	Intervention	2025-04-29	<NULL>	<NULL>	7971	Effect of Polydextrose consumption of the intestinal microbiota,  inflammatory and oxidative stress markers, immune profile, and glycemic control of patients with Gestational Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-20	Universidade Federal de Santa Catarina	Hospital Universitário Polydoro Ernani de São Thiago - HU/UFSC/EBSERH	https://ensaiosclinicos.gov.br/rg/RBR-10dnk8pg	<NULL>	Adult patients over 19 years of age, with GDM diagnosed between 24 and 28 weeks of gestation by OGTT, who have a eutopic pregnancy, with only one embryo and who accept and sign the Informed Consent Form (TCLE).	Exclusion Criteria: Alcoholism, alcoholism, drug use, presence of fetal malformations, psychiatric, neurological, autoimmune, renal, hepatic diseases, inflammatory bowel diseases, previous type 1 or 2 Diabetes Mellitus, immunodeficiencies, allergies or food intolerances, hyperemesis gravidarum, use of anti-inflammatory drugs in the last 30 days and use of antibiotics and supplements or complements containing pre, pro or synbiotics in the last 90 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-6hwcyyg	The Influence of the Pharmacist on the Treatment of Patients with Heart Failure: a Randomized Clinical Trial	Recruitment completed	Intervention	2025-04-29	<NULL>	<NULL>	7972	Effects of Pharmaceutical Intervention in patients with Heart Failure: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Carla Daniely Pombal Bianchini	Centro Universitário Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-6hwcyyg	<NULL>	Patients aged 18 years or older, of both sexes, with a diagnosis of HF syndrome will be included: HF with reduced ejection fraction or preserved HF, as defined by the Brazilian Guidelines for Chronic and Acute Heart Failure (2018), in use of drug treatment. The selection will take place at Centro Universitário FMABC (HF Ambulatory),  with patients that are using medicine treatments.	Patient being evaluated for heart transplantation; patient being evaluated for use of a ventricular assist device; severe lung disease; neoplasm; patient with renal dysfunction and need for dialysis and patient with cognitive difficulties that prevent the completion of the study questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-3xbwpfz	Medical approach to Varicose Veins	Recruiting	Intervention	2025-04-28	<NULL>	<NULL>	7960	Contemporary and holistic approach to Chronic Venous Disease	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-07-08	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3xbwpfz	<NULL>	Age greater than or equal to 18 years; no upper age limit; patients of both sexes; surgical risk classified by the American Society of Anesthesiologists as I to III; clinical presentation of itching, pain, tightness, skin irritation, heaviness, cramps, or other symptoms secondary to chronic venous disease congestion; presence of tributary varicose veins with reflux, enlarged with a diameter equal to or greater than 3 millimeters and tortuous; Doppler ultrasound of the great saphenous vein showing venous reflux greater than 0.5 seconds in the standing position after manual compression maneuver of the calf upstream; diameter equal to or greater than six millimeters in cross-section in the thigh, 15 cm below the saphenofemoral junction; clinical classification 2 to 6; agreement with the proposed protocol and signing of the consent form	Pregnancy or breastfeeding; severe systemic disease, ongoing neoplasia, or without oncological criteria for cure; prolonged restriction of mobility; history of or current manifestation of thrombophilia, deep vein thrombosis, or pulmonary embolism based on history, physical examination, or complementary methods; absence of the posterior tibial and dorsalis pedis pulses, with an ankle brachial index of less than 0.9; prior surgical treatment for the cure of varicose veins, whether conventional surgery or endovenous ablation, that included access to the saphenous vein in the thigh; ultrasound of the candidate axial vein for intervention showing aplasia, hypoplasia, occlusion, or segmental tortuosity that precludes the progression of the endolaser fiber	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-9rsrk6h	How laser treatment can relieve knee pain caused by arthritis	Data analysis completed	Intervention	2025-04-28	<NULL>	<NULL>	7961	Effect of Low-Level Laser Therapy in Patients Diagnosed with Knee Osteoarthritis	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-03-13	Universidade Federal do Amazonas	Instituto de Saúde e Biotecnologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9rsrk6h	<NULL>	Individuals of both sexes. Age between 50 and 74 years old. Diagnosis of symptomatic knee osteoarthritis. Minimum pain intensity of 3 on the Visual Analog Scale (VAS). Meet the classification criteria of the American College of Rheumatology, including: joint pain; functional changes; presence of crepitus in the knee; joint stiffness lasting an average of 30 minutes; presence of osteophytes identified by imaging studies. Pain and functional disability in the knee for at least 3 months. Radiographic classification between grades 2 and 4 on the Kellgren–Lawrence scale	Individuals with the following complications: neoplasms; dementia; neurological deficits (sensory or motor); uncontrolled systemic arterial hypertension; patients using antidepressants; or who had acute infections; vascular complications; epilepsy; gravid uterus; burns as well as patients using pacemakers and patients using anti-inflammatory or analgesic medications; symptomatic hip OA; acute diseases; other rheumatic diseases; systemic or orthopedic that could interfere with the results and the performance of the tests; all these cases were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-8w2kjkn	Effects of edible mushroom supplementation on Hypertension, heart function and gut: a clinical study	Recruiting	Intervention	2025-04-28	<NULL>	<NULL>	7962	Effects of mushroom (pleurotus ostreatus) supplementation on blood pressure, autonomic function, and gut microbiota in patients with Arterial Hypertension: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Centro de Ciências da Saúde da Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8w2kjkn	<NULL>	Adults aged 20 to 59 years; both sexes; medical diagnosis of high blood pressure; eutrophic nutritional status	People with disabilities that prevent them from taking exams; pregnant women; kidney disease; dyslipidemia; diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-8cj7smm	Comparison of the immediate effects of transcranial electrical stimulation with different current patterns on cortical metrics among healthy individuals, with ADHD and depressive symptoms	Recruiting	Intervention	2025-04-28	<NULL>	<NULL>	7963	Comparison of the immediate effects of transcranial electrical stimulation with different current patterns on cortical metrics among healthy individuals, with ADHD and depressive symptoms	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-30	Instituto de Ciências da Vida da Universidade Federal de Juiz de Fora - ICV UFJF GV	Instituto de Ciências da Vida da Universidade Federal de Juiz de Fora - ICV UFJF GV	https://ensaiosclinicos.gov.br/rg/RBR-8cj7smm	<NULL>	Young adults; men and women; between 18 and 30 years old; with hearing acuity; no self-reported use of psychoactive substances	Individuals with epilepsy; taking anticonvulsant medication and/or sleep deprivation; with photosensitivity; with a history of seizures for any reason; with metallic materials implanted in or near the head; with pacemakers or cardiac wires (Stents) or with another active device in which interaction with the electric field may interfere with its functioning; participants with eczema on the head will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-6khstfv	Breastfeeding and Buzzy® in reducing pain during childhood vaccination: randomized clinical trial	Data analysis completed	Intervention	2025-04-28	<NULL>	<NULL>	7964	Pain management and the use of technologies in nursing care during childhood vaccinations	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-12	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6khstfv	<NULL>	Infants of both genders; aged two to twelve months; breastfed; who attended the sector to receive the pentavalent vaccine, at the time of data collection, accompanied by a legal representative, over 18 years old and who demonstrated consent for the infant&apos;s participation in the investigation	Infants who have not received the pentavalent vaccine for any reason; infants with a history of treatment with prophylactic analgesics within a period of up to eight hours prior to the administration of the vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-22g4hbz	How different Exercise intensities affect pain, mobility, and quality of life in people with Hip Osteoarthritis: a clinical study	Recruiting	Intervention	2025-04-28	<NULL>	<NULL>	7965	Effects of different Exercise intensities on pain, physical function, and quality of life in Individuals with Hip Osteoarthritis: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-22g4hbz	<NULL>	Individuals with a clinical diagnosis of unilateral or bilateral hip osteoarthritis according to at least one of the criteria established by the American College of Rheumatology: hip pain, internal rotation less than 15º and flexion less than 115º; sedentary; both sexes; age between 25 and 70 years; patients will be classified according to the severity of osteoarthritis according to radiographic findings of hip osteoarthritis by the Kellgren and Lawrence Osteoarthritis Classification	Individuals with total or partial hip and/or knee arthroplasty; patients on the waiting list for hip arthroplasty surgery; morbid obesity; general health status compromised by serious or decompensated systemic diseases; cognitive or neurological impairment; those who already undergo some other type of conservative treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-3hsqzqz	Research using technology to promote healthy eating among teenagers	Not yet recruiting	Intervention	2025-04-28	<NULL>	<NULL>	7966	Clinical trial using Digital Technology to promote healthy eating among adolescent students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2026-03-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-3hsqzqz	<NULL>	Adolescents must be attending high school and be regularly enrolled in the selected school; have a smartphone and internet access and use WhatsApp; the teenager signs the Term of Free and Informed Assent - TALE and have parental consent by signing the Institution&apos;s Consent Form - TCLE; age between 15 and 19 years old; both sexes	Adolescents who have physical and/or mental limitations that may prevent their participation during the program evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-7thvb56	Therapeutic effects of jaboticaba (Plinia jaboticaba) peel on ulcerative colitis	Recruiting	Intervention	2025-04-28	<NULL>	<NULL>	7967	Therapeutic effects of jaboticaba (Plinia jaboticaba) peel dry extract on ulcerative colitis: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-19	Hospital das Clínicas da Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7thvb56	<NULL>	Inclusion criteria: sex: men and women; age: adults and elderly people (18-80 years old); time since diagnosis of ulcerative colitis: more than six months from the beginning of the experimental protocol, being confirmed by radiological, endoscopic, and/or histological analyses; disease activity: mild or moderate clinical stage, according to the Mayo score, and fecal calprotectin higher than 300 ug/g; other diseases: patients without recurrent enteric infections, not requiring surgery and without high severity for intestinal, hepatic, renal, endocrine, respiratory, neurological, and/or cardiovascular diseases; biological condition: non-pregnant and non-lactating women; medication: patients receiving medication for ulcerative colitis beginning more than 6 months after diagnosis and patients not receiving antibiotics; diet and body weight: omnivores and patients who do not consume drinks or foods based on berries (red fruits) and/or rich in bioactive compounds; with low or adequate consumption of dietary fiber; and eutrophic or overweight according to the Body Mass Index; and non-alcohol dependent and non-smokers	Exclusion criteria: age: children and adolescents (0-18 years); time since diagnosis of ulcerative colitis: less than six months from the start of the experimental protocol, being confirmed by radiological, endoscopic, and/or histological analyses; disease activity: normal/remission or severe clinical stage, according to the Mayo score, and fecal calprotectin lower than 300 ug/g; other diseases: patients with recurrent enteric infections, requiring surgery and with high severity for intestinal, hepatic, renal, endocrine, respiratory, neurological and/or cardiovascular diseases; biological condition: pregnant and lactating women; medication: patients receiving medication for ulcerative colitis beginning less than 6 months after diagnosis and patients receiving antibiotics; diet and body weight: vegetarians and patients who continuously use drinks or foods based on berries (red fruits) and/or rich in bioactive compounds; who consume a high level of dietary fiber; and obese or malnourished according to BMI; and alcohol dependents and smokers. Additionally, during the implementation of the experimental protocol, the following exclusion criteria will be adopted: patients with complications or in need of changing drug therapy that violates the inclusion criteria; and patients who decide to withdraw from the study or who are unable to follow the recommendations of the experimental protocol (more than 20% failure to adhere to treatment)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-10gfr3fb	Impact of diets with different degrees of processing and energy density on health	Recruitment completed	Intervention	2025-04-28	<NULL>	<NULL>	8445	Metabolic effects of diets free or rich in ultra-processed foods and with high or low energy density in healthy adults: randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-07	Faculdade de Nutrição - Universidade Federal de Alagoas	Faculdade de Nutrição - Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-10gfr3fb	<NULL>	Age between 19 and 30 years; both sexes; body mass index between 18.5 and 24.9 kg/m²; body mass index between 18.5 and 30 kg/m²; bioimpedance fat percentage &lt;30% for men and &lt;42% for women; stable weight for at least 1 month; willing to follow the schedule proposed by the research	Chronic use of any medication (eg. : anti-diabetics, anti-hypertensives, anti-depressants, anti-retrovirals, immunosuppressants); altered fasting blood glucose, blood pressure or lipid profile; condition that makes it impossible to perform anthropometry, measurement of energy expenditure components, or blood collection; individuals who are unable to consume the diet provided and/or have any food intolerances/allergies/restrictions; disordered eating behavior assessed using the Three-Factor Eating Questionnaire-18 tool; smokers; pregnant and breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-8nqsfsn	Effects of Melatonin Supplementation on Sleep Quality in Patients with Advanced Glaucoma	Recruitment completed	Intervention	2025-04-27	<NULL>	<NULL>	7957	Randomized Clinical Trial: Effects of Melatonin Supplementation on Sleep Quality in Patients with Advanced Glaucoma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-04	Universidade Federal de Sao Paulo ( UNIFESP)	Associação Fundo de Incentivo à Pesquisa ( AFIP)	https://ensaiosclinicos.gov.br/rg/RBR-8nqsfsn	<NULL>	Patients over 40 years of age and under 80 years of age; both genders; diagnosed with glaucoma (determined by at least 2 criteria: optic nerve excavation on retinography examination, greater than 0.6; typical defect in perimetry; localized damage to the nerve fiber layer); informed consent form granted	Patients with a history of depression; intraocular surgeries (except cataract surgery); ocular trauma; who work at night; systemic medications for sleep disorders; or intolerance to the use of medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-10b6dcpr	Antimicrobial photodynamic therapy and photobiomodulation in alveolar socket healing of diabetic Patients	Terminated	Intervention	2025-04-27	<NULL>	<NULL>	7958	Antimicrobial photodynamic and photobiomodulation therapies on alveolar dental socket repair in diabetic patients: a double-blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10b6dcpr	<NULL>	Type 2 diabetic patients of both genders; age between 35 and 60 years; requiring extraction of erupted permanent teeth, either by simple alveolar techniques or complex open flap extractions; clinical and laboratory examinations performed to standardize the sample; fasting blood glucose levels between 110 and 250 mg/dl; glycated hemoglobin (HbA1c) values up to 7.5%; controlled hypertension with an average blood pressure up to 150/100 mmHg	"We did not include individuals who had used analgesic or anti-inflammatory drugs in the last 15 day Smokers
Patients in use of antiresorptive drugs ز  patients with renal insufficiency; a history of hypothyroidism or hyperthyroidism. chronic pain. neurological or psychiatric disorders; pericoronitis; or any other condition indicative of acute local infection or bisphosphonates at any time; were excluded; Smokers, pregnant women, individuals with a family history of photosensitivity; and those allergic to postoperative pain medications or anti-inflammatory drugs were also not included"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-4596xc2	Comparison of the effects of prescribed physical exercise after an evaluation performed using a treadmill walk test versus the Six-Minute Walk Test in a corridor in patients with coronary artery disease: a randomized controlled clinical study	Not yet recruiting	Intervention	2025-04-27	<NULL>	<NULL>	7959	Comparison of the adaptations induced by physical training prescribed based on the cardiopulmonary exercise rest and the six-minute walk test in patients with coronary artery disease: a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-30	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4596xc2	<NULL>	Volunteers diagnosed with coronary artery disease; over 18 years old; no restrictions regarding gender	Volunteers with contraindications for moderate physical training; contraindications for performing any of the assessment methods; orthopedic limitations; non-adherence to pharmacological treatment; non-adherence to the cardiovascular rehabilitation program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-6jyrdyk	Taping Technique in shoulder surgery for neck edema reduction and prevention of airway complications during extubation	Recruitment completed	Intervention	2025-04-25	<NULL>	<NULL>	7955	Taping Technique in shoulder arthroscopy to minimize cervical edema and avoid airway complications in extubation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Regional Integrada do Alto do Uruguai e das Missões - Campus Erechim	Universidade Regional Integrada do Alto do Uruguai e das Missões - Campus Erechim	https://ensaiosclinicos.gov.br/rg/RBR-6jyrdyk	<NULL>	Volunteers with a clinical indication for elective shoulder arthroscopy; both genders; aged 18 years or older	Volunteers with spondylosis or significant cervical deformities; allergic to the components of the micropore tape	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-85xz9cq	Effect of functional training and resistance training in People with Fibromyalgia	Recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7949	Effect of functional training versus resistance training in individuals with Fibromyalgia: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal de Sergipe - UFS	Laboratório de Pesquisa em Neurociências	https://ensaiosclinicos.gov.br/rg/RBR-85xz9cq	<NULL>	People with fibromyalgia of both sexes; aged between 18 and 60 years; diagnosis of fibromyalgia based on the recommendations of the American College of Rheumatology of 2016; respond negatively to all questions on the Physical Activity Readiness Questionnaire; physically independent; do not have disorders that prevent them from exercising; have not been engaged in physical exercise for at least three months	Neurological conditions that interfere with evaluations, such as paralysis, significant sensory alterations, and levels of consciousness/comprehension; advanced joint diseases; suspected thrombosis, heart diseases, and immediate post-operative periods; pregnancy; alcohol abuse and illicit substance use; active cancer; initiating another type of physical exercise during the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-4mp6nvg	Evaluation of a nutritional education program to prevent childhood obesity in Guaíba, Rio Grande do Sul	Not yet recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7950	Evaluation of a community intervention program for food and nutrition education to prevent childhood obesity in the municipality of Guaíba, Rio Grande do Sul: a randomized field trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-10-01	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	https://ensaiosclinicos.gov.br/rg/RBR-4mp6nvg	<NULL>	Volunteers aged between 4 and 6 years old; both genders; enrolled in preschool education; residents of the municipality of Guaíba; parents and guardians of preschoolers; preschool teachers; health agents working in the school health program	Volunteers in wheelchairs; volunteers diagnosed with cerebral palsy; volunteers diagnosed with autism spectrum disorder; volunteers diagnosed with Down syndrome; volunteers diagnosed with heart disease; volunteers diagnosed with endocrine diseases; teachers and health agents of the school health program who have sick leave; teachers and health agents of the school health program who have maternity leave	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-9t97hgt	Auriculotherapy for people affected by flooding in Rio Grande do Sul	Recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7951	Auriculotherapy in post-natural disaster care in Rio Grande do Sul	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-06	Universidade Federal de Santa Maria	Programa de Pós-Graduação em Enfermagem da Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-9t97hgt	<NULL>	Residents of Bento Gonçalves affected by the natural disaster; who needed to evacuate their place of residence or work; who suffered significant loss of material assets, documented or self-reported; mourning for family, friends or acquaintances as a direct consequence of the disaster; minimum age of 18 years; both sexes	People with a history of known allergy to materials used in the intervention such as micropore, adhesive tape, crystal spheres or seeds; presence of lesion or active inflammation in the ear; current treatment with Auriculotherapy or auricular acupuncture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7gs22jk	Food and the heart: the benefits of a Nutritional Intervention for people with Heart Failure	Not yet recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7952	Effect of a Nutritional Intervention on clinical, laboratory and quality of life parameters of patients with Heart Failure: 6-month follow-up	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos	Hospital Universitário da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7gs22jk	<NULL>	Agreement to participate in the study and signing of the Free and Informed Consent Form - TCLE. Patients diagnosed with Heart Failure - HF. HF with slightly reduced ejection fraction or HF with reduced ejection fraction, with ventricular ejection fraction less than 50%, according to the last echocardiogram performed. Patients over 18 years of age. Both sexes. Patients free of decompensation due to HF for at least 3 months before inclusion in the project	Pregnant women. Breastfeeding women. Patients with limitations in understanding the guidelines: such as the presence of cognitive disorders or difficulties in reading or understanding the booklet	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-34y3bts	The benefits of Pneumatic Compression Boot on muscle pain, fatigue sensation, and physical performance in basketball players	Recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7953	Effectiveness of Intermittent Pneumatic Compression on exercise-induced muscle damage in basketball athletes: a randomized crossover trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-15	Faculdade de Fisioterapia da Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-34y3bts	<NULL>	Basketball athletes; of both sexes; regardless of ethnicity; aged 18 to 35 years will be included in the study	Participants self-reporting any musculoskeletal pain; or discomfort in the lower limbs at baseline will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-9m634y8	Initial filling of 0.9% Sodium Chloride versus 20% Albumin in preventing blood pressure drop in patients with Acute Renal Failure during hemodialysis: a comparative clinical study	Recruiting	Intervention	2025-04-24	<NULL>	<NULL>	7954	Initial priming of 0.9% Sodium Chloride vs 20% Albumin in preventing hemodynamic instability in patients with Acute Kidney Injury during hemodialysis: a randomized clinical trial	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2025-04-01	Hospital das Clínicas da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	Hospital das Clínicas da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9m634y8	<NULL>	Men and women; over 18 years old; with acute kidney injury; admitted to the intensive care unit using norepinephrine at a dose of 0.3 to 0.6 ucg/kg/min; and undergoing prolonged hemodialysis for at least 3 sessions	Patients under 18 years of age; and treated with less than two sessions of prolonged hemodialysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:39
RBR-3nvyrtg	Use of Laser Therapy to prevent Infection at the site (jararaca) Snake Bite in the Brazilian Amazon	Recruiting	Intervention	2025-04-24	<NULL>	<NULL>	8009	Efficacy of Photobiomodulation in reducing Secondary Infections in Bothrops Envenomations in the Brazilian Amazon: randomized clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Escola Superior de Ciências da Saúde da Universidade do Estado do Amazonas	Fundação de Medicina Tropical Dr. Heitor Vieira Dourado	https://ensaiosclinicos.gov.br/rg/RBR-3nvyrtg	<NULL>	Present clinical characteristics of a Bothrops snakebite accident, regardless of sex and age; have occurred less than 24 hours before the snakebite accident; have not undergone serum therapy for a current Bothrops snakebite accident in another institution; no minimum age was defined, however, in relation to children, only those who understand the procedure, agree to participate in the research together with their legal guardian and who understand/accept the use of protective glasses will be included	Patients who have a clearly established secondary infection at the time of admission; immunocompromised patients, those with autoimmune disease or microorganisms that compromise the immune system; who have used antibiotics in the last 30 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-4shpqhj	Effect of Therapeutic Ultrasound on recovery after Elbow Fracture surgery	Not yet recruiting	Intervention	2025-04-24	<NULL>	<NULL>	8050	Additional effect of Therapeutic Ultrasound in postoperative rehabilitation of Elbow Fractures: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-16	Universidade Federal de Juiz de Fora	Programa de Pós Graduação em Saúde Faculdade de Medicina da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4shpqhj	<NULL>	Individuals aged 18 to 70 years; of both sexes; referred for physiotherapy treatment from the sixth week of surgical intervention after elbow fractures; with limited range of motion greater than or equal to twenty degrees of extension deficit; or less than or equal to one hundred and twenty degrees of elbow flexion; elbow fractures involving the distal segment of the humerus; proximal segment of the ulna; fracture of the neck and head of the radius according to Mason&apos;s Classification; elbow fractures and dislocations such as Hotchkiss&apos;s terrible triad; Monteggia lesion; transolecranon fracture and dislocation	Patients with bilateral elbow fractures or whose indicated treatment is total elbow arthroplasty; pregnant women; neurological, rheumatic or psychiatric diseases that compromise rehabilitation; previous history of elbow stiffness; previous surgical procedure on the elbow; existence of Kirschner wires or cerclage wires in the proximal ulna and distal humerus; Mini-Mental State Examination score of less than 24 points for those with higher education and 18 points with low to moderate level of education	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-10nbjgb9	Effect of Transcranial Direct Current Stimulation (tDCS) in Attention Deficit Hyperactivity Disorder (ADHD)	Recruiting	Intervention	2025-04-24	<NULL>	<NULL>	8187	Therapeutic response of Transcranial Direct Current Stimulation (tDCS) in Attention Deficit Hyperactivity Disorder (ADHD): a double-blind pilot clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-10	Universidade Estadual do Sudoeste da Bahia	Clínica Quality	https://ensaiosclinicos.gov.br/rg/RBR-10nbjgb9	<NULL>	Volunteers aged between 18 and 50 years; both sexes; diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) confirmed by a specialist through clinical evaluation; if previously diagnosed with Attention Deficit Hyperactivity Disorder (ADHD), not using psychostimulant medication in the last 30 days; participants must be available for daily sessions of Direct Current Electrical Stimulation	Severe depression; Moderate to severe anxiety; Bipolar disorder with an episode of mania or depression in the last year; Schizophrenia or other psychotic disorder; Autism Spectrum Disorder; positive screening for substance use (alcohol, tobacco and other psychoactive substances); severe neurological and organic comorbidities (seizures, neoplasms, previous neurosurgery); carriers of cochlear implants or other metal implants; pregnant women or recent intention to become pregnant; family history of sudden death before age 50	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-25rft3r	Effect of moderate-paced music on walking ability and muscle metabolism in people with Peripheral Arterial disease	Not yet recruiting	Intervention	2025-04-23	<NULL>	<NULL>	7946	Effect of medium-pace music on walking ability and muscle metabolism of claudicating individuals with Peripheral Arterial disease: a quasi-experimental study	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-25rft3r	<NULL>	Homens e mulheres; Age ≥ 18 years; Diagnosis of peripheral arterial disease with ankle-brachial index &lt; 0.90 at rest; Individuals without physical and cognitive limitations for performing and understanding the procedures; In case of hearing impairment, the participant may only participate if they have correction by a prosthesis that guarantees their exposure to sound stimuli	Participants with clinical conditions that contraindicate physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-89svjw3	Effect of Functional Training on cognition and functionality of elderly women	Recruitment completed	Intervention	2025-04-23	<NULL>	<NULL>	7947	Effect of Functional Training on cognitive health and functional independence in postmenopausal women with Cognitive Impairment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-89svjw3	<NULL>	The sample consisted of elderly women; aged between 60 and 80 years; physically independent and literate; who were not undergoing hormone replacement therapy and had a history of one year since their last menstruation; presenting a Montreal Cognitive Assessment (MoCA) score &lt; 26; and who had subjective memory complaints (SMC); living near the institution and adjacent areas; free from neurological diseases (dementia; Parkinson&apos;s disease; Alzheimer&apos;s disease; multiple sclerosis; depression) or recent surgeries; vision problems (hyperopia; color blindness); hearing; musculoskeletal and cardiorespiratory problems that prevented the practice of high-intensity physical exercises	Attendance below 70%; absence from assessments; engaging in another type of physical activity practice at the same time as the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-3xqdph2	Respiratory muscle training combined with physiotherapy in hemodialysis patients	Data analysis completed	Intervention	2025-04-23	<NULL>	<NULL>	7948	The effectiveness of respiratory muscle training combined with physiotherapy in hemodialysis patients: a randomized study.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-05	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-3xqdph2	<NULL>	Individuals with chronic renal failure undergoing hemodialysis in the Nephrology Department of the Hospital for at least three months of hemodialysis; of both sexes; between 18 and 70 years old; in stable clinical conditions	Patients who will undergo kidney transplantation during the intervention period; who are unable to understand and follow the research protocols; people in wheelchairs; who have medical contraindications to performing physical and/or breathing exercises; those who do not agree to sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:17
RBR-2p4ycn9	Periodontal support alterations and the relationship of occlusal profile and bone losses	Recruitment completed	Intervention	2025-04-22	<NULL>	<NULL>	7945	Prevalence of periodontal support alterations and the relationship of occlusal profile and bone losses with periodontal risk	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-28	Universidade de Sao Paulo	Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2p4ycn9	<NULL>	Patients over 18 years old; regardless of gender; who have periodontal disease; at least one posterior occlusal support.	Patients classified as B4 and C according to the Eichner Index; patients undergoing orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-9mqpwbw	Cardiac control after Pediatric Heart Surgery	Not yet recruiting	Observational	2025-04-21	<NULL>	<NULL>	7940	Cardiac autonomic control in the postoperative period of Pediatric Cardiac Surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-04-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-9mqpwbw	<NULL>	Children and adolescents diagnosed with congenital heart disease; of both sexes; aged between the first day of life and 17 years, 11 months and 29 days; who do not use a cardiac pacemaker; and with acceptance of the consent form by the child&apos;s legal guardians, and the assent form by the child over 2 years old	Inability to remain with the polar capture device for a specified period of time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-9w6wd89	Recovery of the diaphragm muscle after removal of mechanical ventilation support	Recruiting	Intervention	2025-04-21	<NULL>	<NULL>	7941	Diaphragmatic rehabilitation after weaning from mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-02	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-9w6wd89	<NULL>	Adult patients; of both sexes; aged 18 years or older; with hypoxemic respiratory failure treated by prolonged invasive mechanical ventilation for more than 48 hours and who have been extubated after a successful spontaneous breathing trial; evaluated by lung ultrasound with a pulmonary ultrasound score of less than 14 points and diaphragmatic dysfunction characterized by a diaphragmatic thickness fraction ≤ 36% diagnosed by diaphragmatic ultrasound	Patients with Chronic Obstructive Pulmonary Disease (COPD); Patients in palliative care; Patients with Respiratory failure secondary to neuromuscular syndromes; Patients without an ultrasound window will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-2nzh9vr	Use of music and ice compress for pain relief in the postoperative cardiac period	Not yet recruiting	Intervention	2025-04-21	<NULL>	<NULL>	7942	Effectiveness of the association of music and cryotherapy in pain relief in mediastinal drain removal after myocardial revascularization: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-10	Departamento de Enfermagem	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2nzh9vr	<NULL>	Being in the post operative of myocardial revascularization surgery; being hemodynamically stable and with Glasgow 15; of both sexes; be able to be assessed using pain scales; be over 18 years old; not have any neurological or cognitive condition that could influence the application of the intervention	Use of continuous sedation or analgesics; opioid use for chronic pain; narcotics addiction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7qtvbh3	Study of the effects of Biperiden drug on reducing the desire to quit smoking	Data analysis completed	Intervention	2025-04-17	<NULL>	<NULL>	7934	Study of the acute effects of Biperiden on nicotine cravings: double-blind, placebo-controlled study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-10-20	Escola Paulista de Medicina	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qtvbh3	<NULL>	Patients with nicotine use disorder, according to DSM-5 criteria; who have intense compulsion, according to the Questionnaire of Smoking Urges-Brief (43 or more points); aged between 18 and 60 years; male and literate (with the ability to write and read Portuguese)	Present other psychiatric disorders (serious such as schizophrenia and bipolar mood disorder); severe disorder criteria when using other drugs or severe cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7khws8d	Clinical performance of composite resin restorations in Non-Carious Cervical Lesions	Recruitment completed	Intervention	2025-04-17	<NULL>	<NULL>	7935	Clinical performance of restorations of non-carious cervical lesions in posterior teeth with bulk-fill composite resins: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-15	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7khws8d	<NULL>	Presence of 4 vital teeth with non-carious cervical lesions on the vestibular surface of premolars and molars; age range from 18 to 64 years; both sexes; present at least 20 teeth; occlusal contact with healthy or properly restored antagonist tooth	Advanced periodontal disease; teeth with pulp alteration or endodontic treatment; participants undergoing orthodontic treatment; severe bruxomas; smokers; participants who make chronic use of analgesics; teeth with tissue loss in the cervical region due to carious lesions; participants with a thin gingival biotype; medical, psychiatric or pharmacotherapeutic history that may compromise the protocol, including chronic use of anti-inflammatory, analgesic and psychotropic drugs; pregnancy or breastfeeding; allergies and idiosyncratic responses to the composition of the products; abutment teeth of fixed or removable prostheses; teeth or support structures with any painful pathology; poor oral hygiene	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-8mfwskg	National study to assess the benefits of Hydrolyzed Collagen as a dietary supplement in healthy women of reproductive age	Recruitment completed	Intervention	2025-04-17	<NULL>	<NULL>	7936	National, single-Center, randomized, placebo-controlled clinical trial to investigate the benefits of oral administration of Hydrolyzed Collagen as a dietary supplement in healthy women of reproductive age	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-20	Centro de Medicina Reprodutiva Dr. Carlos Isaia Filho LTDA.	Centro de Medicina Reprodutiva Dr. Carlos Isaia Filho LTDA.	https://ensaiosclinicos.gov.br/rg/RBR-8mfwskg	<NULL>	Healthy participants; female; aged between 18 and 45 years; able to confirm voluntary participation; agree with all the purposes of the trial by signing and dating the informed consent form in two copies; have a negative pregnancy test at the screening visit; have agreed to maintain their usual lifestyle regarding physical activities throughout the study; patients with a T-score of -2.5 standard deviations or higher in the bone densitometry result performed at screening; available to attend all study assessment visits	The participant must not have used collagen in the last 3 months; have current injuries, prolonged immobilizations, and/or pain in the musculoskeletal system (muscle, cartilage, or bone); have a recent history of surgery due to bone fracture; have any contraindications to functional food or intolerance to any of the experimental components or placebo; have a past or present history of malignant disease; have received intra-articular injections such as hyaluronic acid, corticosteroids, or similar in the last 6 months; have used glucosamine with or without chondroitin sulfate in the last 6 months; regularly use anti-inflammatory drugs, statins, beta-blockers, or any medications that the evaluator deems may influence collagen metabolism; be pregnant, planning pregnancy, or lactating; have chronic cardiovascular, renal, hepatic, neurological, endocrine (including osteoporosis), metabolic, or infectious disease, or severe hematological disease; be vegan (due to the origin of the supplement to be used); consume more than 21 units of alcohol (equivalent to 1 glass of wine, 1 can of beer, or 1 shot of distilled liquor per day) per week; be a participant with synovitis and synovial effusion in the knee; have gastrointestinal diseases that may affect collagen absorption; present any clinical findings (clinical/physical assessment) or pre-existing laboratory conditions that are interpreted by the investigator as a risk to the participant’s involvement in the clinical trial; be a participant using or planning to use prohibited medications and/or supplements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-44cdrz2	Study on the acceptability and effectiveness of a Denture Adhesive Cream	Not yet recruiting	Intervention	2025-04-17	<NULL>	<NULL>	7937	ORC_128728_EN24-0214-01_Dental acceptability evaluation with perceived effectiveness for health product	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Kley Hertz Farmacêutica S.A	Medcin Instituto da Pele Ltda	https://ensaiosclinicos.gov.br/rg/RBR-44cdrz2	<NULL>	Healthy volunteers; both genders; aged between 18 and 70 years; users of removable dental prostheses; who have used or currently use adhesive creams; agreement to follow the study procedures and attend the center on specified dates and times for evaluations; understanding, consenting, and signing the informed consent form	Pregnancy or risk of pregnancy, breastfeeding; use of anti-inflammatory, immunosuppressive, antihistamine drugs up to 3 weeks prior to selection; atopic history or allergies to health products in this category; active pathologies and or skin lesions (localized and or widespread) in the evaluation area; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; relevant clinical history or current evidence of alcohol or drug abuse; known history or suspected intolerance to products in the same category; Intense sun exposure up to 15 days prior to the evaluation; aesthetic or dermatological treatments up to 4 weeks prior to the evaluation; other conditions considered by the investigator as reasonable for disqualification from study participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-4qqbzzz	Alpha-lipoic acid as an adjuvant in the treatment of depression	Recruiting	Intervention	2025-04-17	<NULL>	<NULL>	7938	Clinical study of Alpha-Lipoic Acid as an adjuvant drug for the treatment of Depression	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-03-18	Departamento de Fisiologia e Farmacologia da Universidade Federal do Ceará	Departamento de Fisiologia e Farmacologia da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4qqbzzz	<NULL>	Male or female participants; aged between 18 and 50 years; diagnosed with moderate depression, assessed using the Hamilton scale; undergoing stable treatment with an antidepressant from the Selective Serotonin Reuptake Inhibitor class for at least four weeks before inclusion in this study; receiving care at the Psychiatry Outpatient Clinic of the Walter Cantídio University Hospital; willing to maintain this medication during the study; capable of understanding the nature and objectives of the study, including its risks and benefits, and willing to cooperate with the researcher and comply with the protocol requirements, as confirmed by signing the Informed Consent Form; patients who do not have clinical conditions that could interfere with the results, such as uncontrolled chronic diseases (diabetes, heart disease, liver disease, and kidney disease)	Participant with a history of severe psychiatric disorders (e.g., bipolar disorder, schizophrenia) or substance abuse; history of autoimmune or inflammatory diseases that may alter cytokine production, or any condition that affects the metabolism of alpha-lipoic acid; known history of hypersensitivity to alpha-lipoic acid or any component of the formulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-58gw8gg	At-home Bleaching with 5% versus 10% Carbamide Peroxide: a randomized, split-mouth, triple-blind, non-inferiority controlled trial	Not yet recruiting	Intervention	2025-04-17	<NULL>	<NULL>	7939	Comparison of bleaching efficacy of 5% vs. 10% Carbamide Peroxide: a randomized, split-mouth, triple-blind, non-inferiority controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-58gw8gg	<NULL>	Patients must be 18 years or older. Both sexes. Being in good general and oral health. With no carious lesions, restorations, or endodontic treatment in the maxillary anterior teeth. The maxillary canines must have a shade of A2 or darker according to the value-oriented Vita Classical shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)	Patients already undergoing tooth whitening; undergoing orthodontic treatment; with severe discoloration due to tetracycline stains and fluorosis; participants with any other pathology that could cause sensitivity (such as recession, exposed dentin or presence of visible fissures in the teeth) or history of hypersensitivity;  pregnant and lactating women; patients with dental bruxism; taking analgesics or anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-67qxnt9	Photobiomodulation in the prevention of induced Trissum by head and neck Radiotherapy	Data analysis completed	Intervention	2025-04-16	<NULL>	<NULL>	7925	Influence of Photobiomodulation in the prevention of induced Trissum by head and neck Radiotherapy: triple blind clinical test, randomized and controlled placebo	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2022-07-13	Instituto do Câncer do Ceará	Instituto do Câncer do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-67qxnt9	<NULL>	Patients over 18 years of age will be included; both sexes; with head and neck cancer in the nasopharynx, maxillary sinuses, oropharynx, mouth and salivary glands; stages I, II, III or IV in which head and neck radiotherapy has been indicated	Patients who underwent previous surgery for tumor resection and/or neck dissection, patients Patients who have undergone previous tumor resection and/or cervical dissection surgery will be excluded; patients with tumor recurrence or recurrence; previous history of head and neck radiotherapy; patients whose radiotherapy dose is less than 40G; patients who withdraw from treatment or the study; who required a change in the therapeutic protocol; who develop extreme toxicity or evolve to death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-9jwzn8d	Evaluation of  virtual reality to reduce anxiety before surgery in adult	Not yet recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7926	Evaluation of immersive virtual reality for reducing preoperative anxiety and increasing satisfaction in adult surgical patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital Santa Cruz Sociedade Anonima	Faculdade Evangélica Mackenzie do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9jwzn8d	<NULL>	Patients of both sexes; aged between 18 and 80 years; with  cognitive ability to interact with the glasses and answer the questions	Patients with hearing or visual impairment; patients with facial infections; or with a history of seizures or migraines; those whose proposed surgeries are due to neoplasms; those requiring intensive care unit admission in the immediate postoperative period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-9p6x9yh	Metformin and health, how the use of the drug is related to diseases in patients with Monoclonal Gammopathy in western Paraná	Recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7927	Use of metformin and the occurrence of diseases and injuries in people with positive Monoclonal Gammopathy of Undetermined Significance (MGUS) in the western macroregion of Paraná	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Estadual do Oeste do Paraná - UNIOESTE	Universidade Estadual do Oeste do Paraná - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-9p6x9yh	<NULL>	Men; over 50 years old; with positive results for Monoclonal Gammopathy of Undetermined Significance; who accept specialized follow-up at the University Hospital of Western Paraná in Cascavel, Paraná	Men who do not accept monitoring or do not sign the Free and Informed Consent Form will be excluded from the study; men who present intolerance to Metformin; gastrointestinal problems that affect the absorption of the medication; who use medications that can interact significantly with Metformin, for example Carbonic Anhydrase; who undergo immunosuppressive therapies; who undergo recent oncological treatments; with metabolic conditions such as Type 1 Diabetes Mellitus; or those who are unable to follow the study instructions or who do not agree to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7v86hk9	Impact of caffeine intake on mental, cognitive and affective health during a strength training session	Not yet recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7928	Evaluation of the effect of acute caffeine Supplementation on affective parameters, cognition, anxiety and mood during a strength training session in an adult population	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-20	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-7v86hk9	<NULL>	Adults; both genders; with or without a diagnosis of Common Mental Disorder; age between 18 and 45 years old; be performing Strength Training for at least 6 months prior to the participant&apos;s first visit	Adults diagnosed with Osteoarthritis; Rheumatoid Arthritis; Infected with HIV Virus; Musculoskeletal Diseases that prevent physical exercise; Hypertensive; people with Cardiovascular Diseases; Pregnant women; Breastfeeding women; Ulcer sufferers; carriers of Gastrointestinal Inflammatory Diseases; volunteers who use Theophylline and Aminophylline, Anticonvulsants, Central Nervous System stimulant drugs such as Methylphenidate (Ritalin® and Concerta®), Lisdexamfetamine (Venvanse®, Juvene®), Bupropion Hydrochloride (Wellbutrin XL®, Zetron XL®, Bup), Lithium Carbonate (Carbolitium®); Smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-7n2w7zt	Ankle exercises on muscle responses in athletes and active adults	Not yet recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7929	Effect of short-foot on musculoskeletal responses in athletes and recreationally active adults: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-7n2w7zt	<NULL>	Adult volunteers of both sexes; must not engage in any physical activity other than that proposed in the experiment; must be free from functional limitations that would prevent them from performing the tests and/or the proposed protocol; and must engage in less than 300 minutes of physical activity per week	Must not be consuming caffeine-based or stimulant ergogenic aids; must not report any acute dizziness; must not present abnormal fluid accumulation (edema), particularly in the lower limbs; must not have been diagnosed with conditions affecting postural control, such as vestibular dysfunction, Alzheimer’s disease, Parkinson’s disease, or motor neuron disorders; must not have a history of lower limb trauma in the past year; and must not be currently engaged in a structured exercise program focused on postural control	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-97579sk	Device replacement after jaw expansion in children	Recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7930	Evaluation of Retaines Replacement After Rapid Maxillary Expansion (RME) in Children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Faculdade de Odontologia da Universidade Estadual Paulista - Júlio De Mesquita Filho	Faculdade de Odontologia da Universidade Estadual Paulista - Júlio De Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-97579sk	<NULL>	Present Free and Informed Consent Ferm duly signed by your legal guardian; and sign the Free and Informed Consent Term; need for rapid jaw expansion; do not present periodontal involvement; do not present contraindications to the treatment itself; patients with incomplete maxillary bone maturation and transverse jaw deficiency; Patients of both genders (female and male); minimum age of 6 years and maximum of 12 years	Having previously performed maxillary expansion; not being included in the age criteria; patients who did not accept the treatment, as well as not signing the Free and Informed Consent Term and Free and Informed Consent Term; patients who have already performed the Rapid Maxila Expansion previously; bone consolidation of the median palatine suture; patients who have periodontal involvement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-43rr3jz	Joint manipulation and myofascial release on cardiac response in physically active and normotensive men and women	Recruitment completed	Intervention	2025-04-16	<NULL>	<NULL>	7931	Acute effect of global manipulation and myofascial release on autonomic and hemodynamic responses in physically active and normotensive men and women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-03	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-43rr3jz	<NULL>	not engaging in any other type of physical activity; not consuming caffeine-based supplements or any substance that alters metabolism; adults; both sexes	Have functional limitations or medical conditions that may compromise your health or confuse the results of the study; be pregnant or breastfeeding; have abnormal fluid accumulation (edema), especially in the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-328krjg	Impact of neuromodulation on cognitive functions altered in Attention Deficit Hyperactivity Disorder (ADHD)	Not yet recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7932	Impact of High-Definition Transcranial Electrical Stimulation with Alternating Current on Executive Functions in individuals with Attention Deficit Hyperactivity Disorder	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-10-01	Campus Integrado de Manufatura e Tecnologia - CIMATEC / SENAI	Campus Integrado de Manufatura e Tecnologia - CIMATEC / SENAI	https://ensaiosclinicos.gov.br/rg/RBR-328krjg	<NULL>	Provision of Free and Informed Consent in writing, signed and dated; provision of the assent term in writing, signed and dated; individuals of both sexes; right-handed; aged 12-18 years; diagnosed with Attention Deficit Hiperativity Deficit (ADHD) according to DSM-V criteria; residing in Salvador and the metropolitan area; enrolled in regular school or who have already completed high school; and who have medical authorization to suspend the use of psycho-stimulant medication for 48 hours prior to the interventions and for an additional 5 days during the intervention period. Individuals of both sexes; aged 12-18 years; without a diagnosis of ADHD; residing in Salvador and the metropolitan area, enrolled in regular school or who have already completed high school.	Research participants who have been involved in clinical study protocols in the last 12 (twelve) months, unless the investigator deems there may be a direct benefit to them (CNS Resolution 251, dated August 7, 1997, item III, subitem J); alcohol and drug abuse (previous diagnosis according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders – DSM-V); use of illegal drug; any clinical condition interpreted by the investigating physician as a risk for the participant’s inclusion in the study, presence of head injuries contraindicating the use of neuromodulation; use of pacemakers; cochlear implants, or metal plates in the head; brain tumors; cranial deformities; diagnosis of depression and/or anxiety disorders, according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V), in the last 6 months; diagnosis of bipolar disorder, schizophrenia, autism spectrum disorder, and other developmental disorders diagnosed according to DSM-V; diagnosis of epilepsy; pregnant individuals; diagnosis of ADHD only with hyperactive presentation; initiation of new psychotropic medications or changes in the dosage of usual medication in the last 3 months; ose of psycho-stimulants 48 hours before and during the intervention; Oral language disorders and cognitive disorders that hinder understanding of the study procedures and the necessary responses; individuals who have suffered acquired neurological disorders or have congenital neurological disorders that may interfere with understanding the study results: cerebrovascular accidents, encephalopathies; visual or auditory impairments that prevent effective use of Virtual Reality; Episodes of nausea and labyrinthitis that, even when treated, hinder the use of Virtual Reality; any condition that, in the opinion of the principal investigator, poses a risk to the research participant during their participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-35czqgf	Clinical and radiographic evaluation of implants with different thread designs and materials for 3D printing dental crowns	Recruiting	Intervention	2025-04-16	<NULL>	<NULL>	7933	Evaluation of clinical and radiographic parameters with different macrogeometries of implants and of 3D printed resin crowns materials	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-35czqgf	<NULL>	Participants over 18 years of age; both sexes; requiring replacement with the use of two unit prostheses on implants in the posterior region of the maxilla or mandible; with healthy adjacent natural teeth (no carious lesions or any stage of periodontal disease); favorable gingival profile (thickness greater than 1.5 mm) and sufficient bone tissue to perform the implantation surgery without bone grafts or augmentations	Smokers; uncontrolled diabetes; metabolic bone disorders; history of radiotherapy to the head and neck; recent chemotherapy treatment; use of drugs that influence bone and gum tissue healing; use of illicit drugs; need for fixed partial dental prostheses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-9nkrhy6	Evaluation of the effects of transcranial magnetic stimulation on postural control in patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2025-04-15	<NULL>	<NULL>	7918	Effects of transcranial magnetic stimulation on postural control of Parkinson&apos;s patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-10	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9nkrhy6	<NULL>	Individuals aged 18 years or older; regardless of gender; who have a clinical diagnosis of Parkinson&apos;s disease, classified as mild to moderate; who have a medical diagnosis of the disease for at least six months; ability to attend scheduled sessions and availability to participate in all stages of the study, including assessments and interventions	Individuals who do not complete the assessments or any stage of the research project, carrying out the tests and applying the questionnaires proposed by the research project; who have a number of absences in interventions greater than 25%; individuals with relative or absolute contraindications to transcranial magnetic stimulation, such as a history of epilepsy or seizures, presence of implanted metal or electronic devices; individuals with severe cognitive deficits, identified during screening, that prevent understanding of the procedures or participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-973mztk	Pilot clinical study of a Dermatological Preparation for the Prevention of Skin Lesions in patients with Breast Cancer treated with Radiotherapy	Recruitment completed	Intervention	2025-04-15	<NULL>	<NULL>	7919	Dermatological Preparation to protect the skin of patients with Breast Cancer undergoing Radiotherapy	<NULL>	2, non-randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2023-01-01	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-973mztk	<NULL>	Women aged between 40 years and 70 years; with invasive breast cancer; with pathological staging I – TNM (tumor -T; lymph node - N; metastasis - M) stage T1N0, i.e., unifocal lesion measuring up to 2.0 cm without lymph node involvement through lymph node sampling from the axilla or sentinel lymph node research; patients with therapeutic plans that involve only breast treatment	Women with a history of collagenosis (rheumatological autoimmune diseases); patients with large breasts, that is, with the distance between the sternum and the mid-axillary line greater than 25 cm; patients with therapeutic plans that involve treatments of areas other than the breasts, such as axillary drainage, supraclavicular or internal mammary fossa drainage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-8bph75x	Eficácia da Terapia Floral: Um estudo com crianças e adolescentes autistas	Recruitment completed	Intervention	2025-04-15	<NULL>	<NULL>	7920	The effectiveness of Saint Germain Flower Therapy in children and adolescents autistic: Double-blind Randomized Clinical Trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2024-03-06	Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8bph75x	<NULL>	Age between 5 and 18 years; both genders; user of the rehabilitation services of the Autism Care Center; sufficient cognitive capacity to perform the method of visualizing flower essences; diagnosis of Autism Spectrum Disorder confirmed by medical report	Severe intellectual disability; users of flower essences prior to the start of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-5nnjt86	Evaluation of the efficacy of the product Pycnogenol in the lightening of Melasma	Recruiting	Intervention	2025-04-15	<NULL>	<NULL>	7921	Orc_118091_en24-0171-01_double-blind, randomized, placebo-controlled clinical trial: evaluation of the efficacy of the investigational product (Pycnogenol®) in the lightening of Melasma_clinical, subjective, and instrumental study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-03-10	Divcom S/A	Medcin Instituto da Pele	https://ensaiosclinicos.gov.br/rg/RBR-5nnjt86	<NULL>	Female participants; aged between 18 and 60 years; mild to moderate facial melasma; present phototype II to IV; no history of using cosmetic products with lightening action in the last 15 days or medications in the last 30 days	Pregnancy/ lactation; skin marks or dermatological conditions that interfere with the evaluation; atopic or allergic history to the product formula or sunscreen or products of the same category; medications that may impact skin pigmentation; active skin pathologies or lesions; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; relevant clinical history of alcohol or drug abuse; intense sun exposure up to 15 days before; aesthetic or dermatological treatment up to 45 days before	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-102x8y2x	Evaluation of the effectiveness of a bioactive remineralizing gel in post-whitening sensitivity with 35% hydrogen peroxide: a randomized, triple-blind, split-mouth clinical study	Recruitment completed	Intervention	2025-04-15	<NULL>	<NULL>	7922	Effectivesness of topical application of a bioactive remineralizing gel on  post-bleaching sensitivy with 35% hydrogen peroxide a randomized, plith-mouth, triple-blind clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-08	Universidade Cesumar	Universidade Cesumar	https://ensaiosclinicos.gov.br/rg/RBR-102x8y2x	<NULL>	Individuals over 18 years of age; good general and oral health; anterior teeth free of caries; who agree to the Informed consent form; have teeth with a color of A2 or darker; both genders	Patients with orthodontic appliances; pregnant or breastfeeding women; restorations on anterior teeth; severe gingival recessions; dental sensitivity; patients who have already undergone teeth whitening; anterior upper teeth that have undergone endodontic treatment or have severe internal discoloration;Patients using analgesic or anti-inflammatory; medications;Those with bruxism habits;Smokers;Visible cracks in their teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-6nzzhqk	Assessment of oxidative stress, damage to the membrane lining the cells of blood vessels, phase angle and clinical evolution in Heart Infarction	Data analysis completed	Observational	2025-04-15	<NULL>	<NULL>	7923	Evaluation of oxidative stress, endothelial glycocalyx injury, phase angle and clinical outcome in Acute Myocardial Infarction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-24	Unidade de Emergência do Hospital das Clínicas de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)	https://ensaiosclinicos.gov.br/rg/RBR-6nzzhqk	<NULL>	Patients diagnosed with acute myocardial infarction with ST segment elevation; male and female; of different races; aged 18 years or older within 72 hours of hospital admission	Patients with diagnosis of renal or hepatic disease; cancer; age over 80 years; use of external orthopedic or cardiac devices; mechanical ventilation; pregnancy; cardiorespiratory arrest or cardiogenic shock at admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-75rsy6w	Effect of Sensory Stimulation on the foot on the mobility, capacity and physical performance of people with Parkinson&apos;s disease	Recruiting	Intervention	2025-04-14	<NULL>	<NULL>	7913	Effect of Hallux Sensory Stimulation on Mobility, Capacity and Performance Functional Performance of people with Parkinson&apos;s Disease: a clinical trial, double blind, randomized and crossed	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Estadual Paulista	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-75rsy6w	<NULL>	Motor limitations caused by Parkinson&apos;s disease, classified as moderate to severe (score 2.5 to 4 on the Hoehn and Yahr scale) and gait impairment characterized by reduced walking speed (speed less than 1.0 m.s-1). Participants whose drug treatment for Parkinson&apos;s disease remains unchanged for at least 30 days before the start of and during the volunteer&apos;s participation in the study. Participants must also be on drug treatment for Parkinson&apos;s disease for at least six months. Minimum age of 60 years. Both sexes	Signs of severe cognitive decline, based on the results of the Mini-Mental State Examination, adjusted according to the educational level for the Brazilian population. Presenting cardiorespiratory, neuromuscular and musculoskeletal diseases, which are not related to Parkinson&apos;s disease, and which make it impossible to carry out tasks security testing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-10jfkh7q	Promoting physical activity among economically disadvantaged adults	Not yet recruiting	Intervention	2025-04-14	<NULL>	<NULL>	7914	Promoting physical activity and equity: overcoming barriers to physical activity participation among economically disadvantaged adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-30	Programa de Pós-Graduação em Educação Física da Universidade Federal de Sergipe	Universidade do Estado do Pará	https://ensaiosclinicos.gov.br/rg/RBR-10jfkh7q	<NULL>	Aged 18 years or older; all gender; not meeting physical activity guidelines (less than 150 minutes of moderate-to-vigorous physical activity per week); not having participated in any physical activity program in the past three months; intending to join a walking/running programme; and agree to the Informed Consent Form by signing it	Individuals with a condition that prevents them from engaging in physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-10m9thvy	Impact of a Gamified Educational Intervention on violence against the elderly on the knowledge of high school students	Recruiting	Intervention	2025-04-14	<NULL>	<NULL>	7915	Development, validation and evaluation of an Educational Game and a Manual on Violence against Elderly People with high school students	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-20	Faculdade de Medicina de Marília	Escola Estadual Sebastião Monaco Vereador	https://ensaiosclinicos.gov.br/rg/RBR-10m9thvy	<NULL>	Be enrolled in high school; of both sexes	Students who do not complete the data collection instrument and/or the Free and Informed Consent Form and/or Free and Informed Assent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-6zyrzjq	The Effects of Virtual Reality Therapy on Hand Use in Children with Cerebral Palsy: A Randomized Clinical Trial Feasibility Study	Recruitment completed	Intervention	2025-04-14	<NULL>	<NULL>	7917	The Effects of Virtual Reality Therapy on Hand Function in children with Cerebral Palsy: a randomized clínical trial feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade do Estado do Pará - Centro de Ciências Biológica e da Saúde	Universidade do Estado do Pará - Centro de Ciências Biológica e da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-6zyrzjq	<NULL>	Children with cerebral palsy; both male and female and aged 4-12 years old; classified according to the Gross Motor Function Classification System Expanded and Revised (GMFCS - E&amp;R) levels I-IV and Manual Ability Classification System (MACS) levels I-IV; with cognitive skills of understanding the verbal commands offered	Children with cerebral palsy (CP) who have undergone treatment with botulinum toxin in the last 6 months in the upper limbs or during the period of intervention with virtual reality (VR); children with cerebral palsy (CP) who have presented neurological complications related to seizures not controlled by medication; who do not agree with the Free and Informed Consent Form (FICF) or Free and Informed Assent Form (FICF)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-7vfx9pv	Affective response to increasing and decreasing intensity physical exercise in adolescents	Not yet recruiting	Intervention	2025-04-10	<NULL>	<NULL>	7912	The affective response to physical exercise of different intensities in adolescents	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	União Brasileira de Educação e Assistência	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7vfx9pv	<NULL>	Healthy volunteers; both genders; aged between 11 and 17 years; agree to participate in the study by signing the consent forms by their guardian and assent by the participant	Self-report of diagnosis of psychiatric disorders; self-report of use of alcohol or drugs; physical inability to perform physical exercise; participant who does not participate in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-7pxmfjc	Acute effects of motor rehabilitation in stroke survivors through resistance training and neuromodulation	Not yet recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7907	Motor rehabilitation in stroke survivors with severe functional impairments through unilateral eccentric training combined with cortical neuromodulation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Instituto de Física Gleb Whatagin	Instituto de Física Gleb Whatagin	https://ensaiosclinicos.gov.br/rg/RBR-7pxmfjc	<NULL>	Patients who suffered a stroke (type 1); patients who have severe hemeparesis as a consequence of the stroke; both female and male patients; patients above 18 years old	Patients who have any type of metal inside their body (pins, pacemakers, metal prostheses, revolver bullets); patients who have any musculoskeletal injury on the affected or unaffected limbs; patients who had previous conditions such as seizures, head trauma, hearing problems and cochlear impalants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-9qsgdqr	Changes in VO2max and oxidative metabolism in different quadriceps muscles during 6 weeks of moderate continuous intensity training and high intensity interval training: a randomized crossover trial	Recruitment completed	Intervention	2025-04-09	<NULL>	<NULL>	7908	Changes in VO2max and oxidative metabolism in different quadriceps muscles during 6 weeks of moderate-intensity continuous training and high-intensity interval training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9qsgdqr	<NULL>	Be at least 18 years of age; to be of the masculine gender; have participated in at least three sessions of physical activity per week, on average, in the month leading up to the start of the study	Use of medications that could potentially interfere with the study results; smokers; participants who answered &quot;yes&quot; to any question on the physical activity readiness questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-4cbtxv2	Auriculotherapy for migraine treatment in women, a clinical study	Recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7909	Effect of Auriculotherapy in the treatment of women with Migraine: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-15	Sociedade de Educação Superior e Cultura Brasil S.A.	Sociedade de Educação Superior e Cultura Brasil S.A.	https://ensaiosclinicos.gov.br/rg/RBR-4cbtxv2	<NULL>	Medical diagnosis of migraine with a minimum duration of one year; women; aged between 18 and 60 years; agreement to participate in the study; formalization of participation through the signing of the Informed Consent Form (ICF)	Women diagnosed with tension headache; other pain syndromes; pregnant women; continuous use of anti-inflammatory drugs; antidepressants; or analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-65p3f3s	Evaluation of the use of Topical Anesthesia in Thyroid surgery	Not yet recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7910	Evaluation of the use of Topical Anesthesia on the airway with Lidocaine and Ropivacaine in patients undergoing Total Thyroidectomy surgery: a randomized study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-06-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-65p3f3s	<NULL>	Patients undergoing total thyroidectomy; both genders; age between 18 and 70 years; American Society of Anesthesiologists (ASA) physical status classification I or II	Patients who refuse to participate in the study; difficult tracheal intubation (trachea not intubated after the first attempt); smoking patients; patients with heart, lung, or neurological diseases; patients with a history of previous laryngeal or tracheal surgery; patients at risk of aspiration of gastric contents; patients requiring the use of a nasogastric or orogastric tube	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-4w9jscv	The effectiveness of using Limb rotation band for treatment of Femoral anteversion in children with in-toeing: a randomized clinical trial	Not yet recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7911	Study and development of Orthosis for treatment of Femoral anteversion in children with In-Toeing: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4w9jscv	<NULL>	Children of both sexes; Age between 4 and 10 years; Present in-toeing pattern due to femoral anteversion; absence of neuromotor or behavioral alteration; gait angle less than -3° and internal rotation of the hip greater than 70°; do not present in-toeing due to internal torsion of the tibia and metatarsus adductus or excessive deformity indicating surgery (over 80° of internal rotation); do not present a history of surgery; fractures in limbs and deformities that affect gait (for example, clubfoot, dislocation of the hip joint)	Low adherence to daily use of the orthosis (less than 4 hours reported); presence of allergies or irritability when using the orthosis; orthopedic surgeries on lower limbs involving the hip; possible fractures in the lower limbs; interruption in the use of the orthosis for more than 15 total days or 7 calendar days; withdrawals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-2zh964c	Treatment of knee Osteoarthritis with blood derivate	Recruiting	Intervention	2025-04-09	<NULL>	<NULL>	7943	Treatment of knee Osteoarthritis with Platelet-rich Plasma: prospective and randomized study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-09-05	Faculdade de Medicina da Universidade Federal Fluminense	Hospital Universitário Antonio Pedro/Empresa Brasileira de Serviços Hospitalares	https://ensaiosclinicos.gov.br/rg/RBR-2zh964c	<NULL>	Age between 40 and 70 years old; both sexes; diagnosis of Bilateral Osteoarthritis of the knee, according to the criteria of the American College of Rheumatology; radiographs with a Kellgren-Lawrence classification of less than III in both knees; present full range of motion (0 to 120°)	History of previous trauma, infection or surgery in the same knee in the last 2 years;limb malalignment (varus&gt;10º and valgus &gt; 15º);corticosteroid infiltration in the same knee in the last 3 months;hyaluronic acid ; unfiltration in the same knee in the last 12 months;inflammatory, autoimmune or neoplasic disease;body mass index&gt; 35 kg/m2; use of immunosuppressants or anticoagulants; active neoplasia; hematologic disorders; history of transmissible disease accute or chronic; living outside Rio de Janeiro metropolitan area; participants without full autonomy, blind, deaf or illiterate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-4hptrpt	Study of the characteristics and safety of two files after being used in three root canal treatments	Recruiting	Intervention	2025-04-08	<NULL>	<NULL>	7901	Analysis of the mechanical properties and safety of two rotary systems after three clinical uses	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-10	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4hptrpt	<NULL>	Adult patients of both genders; aged 18 to 60 years; requiring primary endodontic treatment of permanent lower first and second molars with completely formed apices; with curvature between 10º and 20º (Schneider, 1971)	Patients with previous endodontic treatments; fractures; root resorptions; teeth with an open foramen; and with a pronounced degree of curvature; severely destroyed teeth in which absolute isolation cannot be achieved.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-43j2rh9	Effects of Extra-articular Reinforcement in Anterior Cruciate Ligament Reconstruction on the clinical and functional status of high-performance athletes	Not yet recruiting	Intervention	2025-04-08	<NULL>	<NULL>	7902	Effects of ACL Reconstruction on the functionality of high-performance athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	https://ensaiosclinicos.gov.br/rg/RBR-43j2rh9	<NULL>	Be a federated athlete who has participated in one or more official competitions in the last two years; be between 18 and 45 years old; have an injury to the Anterior Cruciate Ligament – ACL, without compromising other ligament structures of the knee; have not undergone previous surgery on the affected joint; of either sex	Presence of post-surgical infection; inability to or refusal to perform follow-up assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-8x78cnz	Walking to improve functionality in hospitalized elderly people	Recruiting	Intervention	2025-04-08	<NULL>	<NULL>	7903	Walking activity to improve functionality in hospitalized elderly – a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Instituto de Medicina Integral Professor Fernando Figueira (IMIP)	Hospital Mestre Vitalino	https://ensaiosclinicos.gov.br/rg/RBR-8x78cnz	<NULL>	Elderly individuals over 60 years of age; admitted to the medical clinic sector; classified as sedentary through the International Physical Activity Questionnaire (IPAQ); both sexes	Classified with severe prior functional impairment through the Barthel Index (26-50 points); inability to ambulate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-39wj7gh	Development of a questionnaire to identify young people in Brazil at higher risk of dental erosion	Recruitment completed	Observational	2025-04-08	<NULL>	<NULL>	7904	Development and validation of a questionnaire to assess susceptibility to Dental Wear by Erosion in young people in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-22	Faculdade de Ciências da Saúde da Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-39wj7gh	<NULL>	Be within the target audience between the ages of eighteen and twenty-nine; be male or female; sign the informed consent form	Individuals outside the established age range; those who refuse to sign the informed consent form; those who have previously participated to avoid repetition bias;  those without access to devices for remote participation will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-10j3s6pd	Cataract surgery in Glaucoma patients	Not yet recruiting	Intervention	2025-04-08	<NULL>	<NULL>	7905	Monofocal Intraocular Lens versus Monofocal-plus Intraocular Lens in Glaucoma patients: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-10j3s6pd	<NULL>	Both gender; Open angle glaucoma and angle-closure glaucoma; cataract with surgical indication; intraocular pressure lower than 21mmHg, with or without medication use; visual acuity above light perception; mild glaucoma at functional and structural evaluation	Intraocular pressure above 21mmHg; high myopia or high hyperopia; axial length above 30mm or lower than 18mm; secondary glaucomas; macular diseases; central loss at visual field; need of antiglaucomatous surgery; use of oral acetazolamide	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-4qyw77g	Restoring Canine Guidance in the control of Bruxism: a pilot study	Terminated	Intervention	2025-04-08	<NULL>	<NULL>	7906	Restoring the Canine Guide as an alternative for controlling Bruxism: a pilot randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-10	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4qyw77g	<NULL>	Healthy people aged 18 - 29. Both sexes. Complete dentition. Absence of bilateral canine guide with signs of wear. Incisal wear with no pain. Reports of bruxism episodes by third parties	Presence of temporomandibular disorders. Presence of other parafunctional habits. Systemic diseases that cause teeth clenching and grinding. Patients with dentures. Absence of teeth. Presence of painful symptoms associated with bruxism. Extensive dental rehabilitations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-7g8pn37	How Rapid Maxillary Expansion (RME) influences kids and teens with symptoms of Obstructive Sleep Apnea?	Recruiting	Intervention	2025-04-07	<NULL>	<NULL>	7896	Influence of Rapid Maxillary Expansion (RME) on Children and Adolescents with Obstructive Sleep Apnea	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-7g8pn37	<NULL>	Pediatric and young patients aged between 6 and 14 years; previous diagnosis of obstructive sleep apnea or symptoms associated with sleep-disordered breathing; both gender	Patients with syndromes or other conditions considered confounding factors; patients undergoing alternative treatments for the disorder; patients who refuse to participate in the study; patients unwilling to attend scheduled appointments; patients who refuse to undergo preliminary examinations; patients who do not sign the informed consent form (ICF)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-8yvd85y	Effect of Whey Protein Supplementation for Mucositis in BMT Patients	Recruitment completed	Intervention	2025-04-07	<NULL>	<NULL>	7897	Effect of Food Supplementation with Enriched Milk Protein Concentrate with TGF-ß in reducing oral Mucositis in patients undergoing BMT	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Universidade Federal de Juiz de Fora	Hospital Universitário da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8yvd85y	<NULL>	Age over 12 years old; both genders; patients who have not started the conditioning phase	Patients who are allergic to milk proteins; lactose intolerants; suspension of oral nutrition during treatment; death occurring during the data collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-5ckc83h	National Study to acess the benefits of Hydrolyzed Collagen as a Dietary Supplement in Healthy postmenopausal women	Recruitment completed	Intervention	2025-04-07	<NULL>	<NULL>	7898	National, single-center, randomized, placebo-controlled clinical study to investigate the benefits of oral administration of Hydrolyzed Collagen, as a Food Supplement, in Healthy postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-19	Centro de Medicina Reprodutiva Dr. Carlos Isaia Filho LTDA.	Centro de Medicina Reprodutiva Dr. Carlos Isaia Filho LTDA.	https://ensaiosclinicos.gov.br/rg/RBR-5ckc83h	<NULL>	Healthy female participants; aged between 45 and 60 years; with the ability to confirm voluntary participation and agree with all the purposes of the trial by signing and dating the informed consent form  in two copies; willing to maintain their usual physical activity lifestyle until the end of the study; patients with a T-score of -2.5 standard deviations or higher in the result of bone densitometry performed during screening (V-1); availability to attend all study evaluation visits; postmenopausal participants with documented evidence; if the participant has not undergone a hysterectomy: at least 12 months of spontaneous amenorrhea; if the participant has undergone oophorectomy: at least 6 weeks post-bilateral oophorectomy procedure; if the participant has undergone a hysterectomy: serum FSH greater than 40 mUI/ml and E2 less than 20 pg/ml	Volunteers who have used collagen in the last 3 months; have undergone unilateral oophorectomy; have current injuries, prolonged immobilizations, and/or pain in the musculoskeletal system (muscle, cartilage, or bone); have a recent history of bone fracture surgery; have any contraindication to functional foods or intolerance to any of the experimental components or placebo; have a past or present history of malignant disease; have received intra-articular injections such as hyaluronic acid, corticosteroids, or similar in the last 6 months; have used glucosamine with or without chondroitin sulfate in the last 6 months; regularly use anti-inflammatory drugs, statins, beta-adrenergic blockers, or any drugs the investigator deems may influence collagen metabolism; have chronic cardiovascular, renal, hepatic, neurological, endocrine (including osteoporosis), metabolic, or infectious diseases, or severe hematological disorders; are vegan (due to the origin of the supplement to be used); consume more than 21 units of alcohol (equivalent to 1 glass of wine, 1 can of beer, or 1 shot of distilled alcohol per day) per week; participants with synovitis and synovial effusion in the knee; have gastrointestinal diseases that may affect collagen absorption; present any clinical findings (clinical/physical evaluation) or previous laboratory condition interpreted by the principal investigator as a risk to the participant&apos;s involvement in the clinical trial; participants using or with plans to use prohibited medications and/or supplements that are interpreted by the principal investigator as a risk to the participant&apos;s involvement in the clinical trial	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-7wt6hzm	Evaluation of Medical and Nutritional Treatment of Obesity through Online Care compared to In-Person Care in patients using Brazil&apos;s Public Health System	Data analysis completed	Intervention	2025-04-07	<NULL>	<NULL>	7899	Evaluation of Medical and Nutritional Treatment of Obesity through Telehealth compared to Conventional Treatment in a sample of patients of Brazil&apos;s Public Health System	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-7wt6hzm	<NULL>	Patients who are already being monitored at the Obesity Outpatient Clinic of the Federal University of São Paulo - UNIFESP (not treatment-naïve). Patients who have already been seen by a doctor in the last 6 months or less at this clinic. Men or women. Over 18 years of age. Agree to and sign a Free and Informed Consent Form (FICF). Agree to attend remotely. Have access to the internet and the possibility of having their blood pressure and weight measured before the remote consultation	Presence of diseases that cause difficulties in understanding and reasoning that indicate cognitive deficits (e.g. intellectual disability, senile dementia, neurological and genetic syndromes, limiting heart diseases, autistic spectrum disorder and psychotic disorders). Presence of Bulimia Nervosa Eating Disorder. Being pregnant or breastfeeding or planning a pregnancy (female patients). History of cancer in the last 5 years. Obesity of secondary cause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-54wsdps	Effects of Pneumatic Compression Boot on Recovery after Exercise in Physically Active People	Recruiting	Intervention	2025-04-07	<NULL>	<NULL>	7900	Effects of different Intermittent Pneumatic Compression pressures on indirect markers of Exercise-Induced Muscle Damage in physically active individuals: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-54wsdps	<NULL>	Men aged between 18 and 35 years; classified as physically active according to the International Physical Activity Questionnaire (IPAQ) classification; who do not perform regular jumping training; who have not used Intermittent Pneumatic Compression prior to this research	Subjects with musculoskeletal injuries or lower limb surgeries within a period of nine months prior to the tests; with an inflammatory rheumatological condition or severe cardiovascular and/or pulmonary disease that prevents them from performing the proposed assessment and tests; with any condition that is contraindicated for performing maximum strength tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-7322n6s	Bone regeneration with absorbable membrane after tooth extraction	Recruiting	Intervention	2025-04-04	<NULL>	<NULL>	7888	Guided regeneration with Polydioxanone (PDO) membrane in dental alveoli after tooth extraction: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Universidade Estadual Paulista Julio de Mesquita Filho	Faculdade de Odontologia da Universidade Estadual Paulista Julio de Mesquita Filho - Campus Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-7322n6s	<NULL>	Have all four bony walls after the extraction procedure; over 18 years old; both genders; have signed the Free and Informed Consent Form	Uncontrolled systemic involvement; teeth in areas of tumor lesions; acute infectious processes; deciduous teeth; untreated periodontal problems; smokers; irradiated in the head or neck region; allergy to any component used in the research; psychological disorders; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-10q9p5pg	Evaluation of the accuracy of a virtual surgical planning protocol in orthognathic surgery planning	Terminated	Observational	2025-04-04	<NULL>	<NULL>	7889	3D virtual simulation in orthognathic surgery: study of the accuracy of the Universal Protocol	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2015-02-07	Faculdade de Odontologia da Universidade de São Paulo - FO-USP	Faculdade de Odontologia da Universidade de São Paulo - FO-USP	https://ensaiosclinicos.gov.br/rg/RBR-10q9p5pg	<NULL>	Patients who underwent bimaxillary orthognathic surgeries; including those undergoing genioplasty or maxillary segmentation; Minimum age of 18 years; no gender restriction	Patients who underwent temporomandibular joint reconstruction surgeries. Patients who had single-jaw orthognathic surgeries. Patients with genetic syndromes; cleft lip/palate; or other craniofacial anomalies. Patients lacking one or more of the following: preoperative clinical photographs; preoperative Computed Tomography with centric relation bite guide; or immediate postoperative Computed Tomography in maximum intercuspation with elastic fixation (up to 1 day post-surgery)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-8sm6kkk	Comparison between treatment with Oral Minoxidil at doses of 1 mg per day and 2 mg per day in the treatment of Female Baldness	Recruitment completed	Intervention	2025-04-04	<NULL>	<NULL>	7890	Oral Minoxidil 1 mg versus Oral Minoxidil 2 mg for treatment of Female Pattern Alopecia: a randomized, double-blind clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-06-01	Clinica Sanabria Transplante e Restauração Capilar	Clinica Sanabria Transplante e Restauração Capilar	https://ensaiosclinicos.gov.br/rg/RBR-8sm6kkk	<NULL>	Females; age between 18 and 60 years; diagnosis of female pattern alopecia classified between grades II and IV on the Sinclair scale	Patients who have undergone previous treatment for hair loss in the last 6 months; patients diagnosed with systemic arterial hypertension, heart disease or kidney disease; patients with other causes of hair loss; presence of dermatoses on the scalp	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-4bk3yjb	Inspiratory muscle training and Inflammatory bowel disease	Other	Intervention	2025-04-04	<NULL>	<NULL>	7891	Effects of inspiratory muscle training on cardiovascular autonomic control and systemic inflammation in patients with Inflammatory bowel disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-06	Instituto Biomédico	Instituto Biomédico	https://ensaiosclinicos.gov.br/rg/RBR-4bk3yjb	<NULL>	Men and women; minimum age of 18 and a maximum of 60 years; participants with inflammatory gastrointestinal diseases in remission for 3 months; participants with the ability to walk independently; participants with no change in medication for at least 30 days prior to the start of the testing protocol; complete blood count, liver enzymes and inflammatory markers performed no more than 30 days ago	History of chronic or acute cardiorespiratory disease, except controlled arterial hypertension; acute pathologies that affect blood pressure and breathing; body mass index &lt; 17 or &gt; 35 kg/m2; cardiac arrhythmia that prevents measurement of cardiac autonomic control; anemia; smoking; previously diagnosed respiratory disorders and lung capacity below 80% of the value predicted by spirometry; severe postural deviation in the sternum or spine such as scoliosis, hyperkyphosis or hyperlordosis that influence the respiratory pattern; osteomyoarticular dysfunction that alters gait and requires assistive devices for walking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-5g9j4pv	Acute effect of functional training on arterial rigidity and ambulatory blood pressure in elderly people with Hypertension	Not yet recruiting	Intervention	2025-04-04	<NULL>	<NULL>	7893	Acute effect of functional training on arterial rigidity and ambulatory blood pressure in elderly people with Arterial Hypertension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-17	Programa de Pós-Graduação em Educação Física - PPGEF	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-5g9j4pv	<NULL>	Elderly people; men and women; hypertensive; sedentary or who had not practiced any type of physical training in the month prior to the start of the intervention; not have uncontrolled heart failure; Parkinson&apos;s; Alzheimer&apos;s; insanity; physical or visual disability; morbid obesity; Cancer; unstable angina; musculoskeletal disorders that limit the performance of exercises; must be under treatment with antihypertensive medications; have medical follow-up; sign the Free and Informed Consent Form	Not completing the functional training session; failing to perform ankle brachial index (ABI) exams; not performing ambulatory blood pressure mapping (ABPM) in the pre- and post-intervention moments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-9gdncdx	Result of action to increase adherence to school meals in the city of Sumidouro-RJ	Recruiting	Intervention	2025-04-04	<NULL>	<NULL>	7894	Effectiveness of an intervention based on food autonomy in adherence to school meals: a school-based randomized community trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-20	Instituto de Medicina Social - Universidade do Estado do Rio de Janeiro	Instituto de Medicina Social - Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9gdncdx	<NULL>	Healthy volunteers; both genders; age between 6 and 15 years; be regularly enrolled in schools participating in the study; sign the Assent Form; return of the Free and Informed Consent Form signed by parents and/or guardians	Students who have some type of physical/cognitive disability that makes it impossible to complete the questionnaires;  students who are pregnant, as they may behave differently than usual at this stage of life	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-6fsbgky	Foam treatment of the saphenous vein	Recruitment completed	Intervention	2025-04-04	<NULL>	<NULL>	7895	Use of Dense Foam in the great saphenous vein	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Hospital Universitário Pedro Ernesto	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-6fsbgky	<NULL>	Age greater than 18 years; patients of both sexes; presenting chronic venous disease with clinical classification C2, C3, C4, C5, or C6 according to Clinical-Etiology-Anatomy-Pathophysiology; presenting proximal, multi-segmental, or diffuse great saphenous vein insufficiency with a diameter greater than 6mm in a segment longer than 20 cm in length; signing the informed consent form	Patients will be excluded in the event that the Doppler ultrasound reveals acute deep vein thrombosis, chronic deep vein thrombosis without recanalization, varicose disease not associated with great saphenous vein insufficiency; patients who have previously undergone varicose vein surgery; patients with thrombophilias; active neoplasia or cancer under treatment; pulmonary diseases or peripheral arterial disease with an ankle-brachial index less than 0.6	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-10nb9dft	Study of a Coffee-flavored Chewing Gum to Improve Bowel Habits After Abdominal Surgery.	Recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7881	Evaluate the effectiveness of coffee flavor chewing gum with the addition of trigoneline for postoperative treatment of paralytic ileus on video cholecystectomy: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-22	Universidade Regional Integrada do Alto Uruguai e das Missões	Universidade Regional Integrada do Alto Uruguai e das Missões	https://ensaiosclinicos.gov.br/rg/RBR-10nb9dft	<NULL>	Research participants who underwent video cholecystectomy in two hospitals in the north of Rio Grande do Sul and presented postoperative paralytic ileus	history of allergies to gum components; diseases that worsen intestinal transit; diabetic patients; patients with chewing difficulties	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-92wcttd	Comparison between Ceftriaxone and Crystalline Penicillin for the treatment of Ocular Syphilis	Recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7882	Ceftriaxone versus Crystalline Penicillin for the treatment of ocular Syphilis: a randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital de Clínicas da UNICAMP	Hospital de Clínicas da UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-92wcttd	<NULL>	Individuals, male or female; over 18 years of age diagnosed with ocular syphilis	History of previously treated syphilis; allergy to penicillin or cephalosporin; immunocompromised individuals not infected with the Human Immunodeficiency Virus (HIV); concomitant severe eye disease that may compromise the analysis of response to treatment of syphilis uveitis (e.g., diabetic macular edema, age-related macular degeneration, previous blindness for other reasons); refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-9mwmq2q	Effects of physical exercise in patients with Diabetes Mellitus	Recruitment completed	Intervention	2025-04-03	<NULL>	<NULL>	7883	Efects of metabolic rehabilitation in patients with Diabetes Mellitus: Randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-30	Hospital Estadual Dr. Alberto Rassi	Hospital Estadual Dr. Alberto Rassi	https://ensaiosclinicos.gov.br/rg/RBR-9mwmq2q	<NULL>	Individuals over 40 years of age; with a clinical diagnosis of type 2 diabetes mellitus; of both sexes; with a self-reported sedentary lifestyle or physical activity level of less than 150 minutes per week; who have agreed to and signed the Free and Informed Consent Form	Individuals with clinical instability; osteomyoarticular; neurological diseases; wounds that make it impossible to perform assessments or physical exercises; individuals with lower limb prostheses and/or amputations of the following types: lisfranc, transtibial or transfemoral; individuals with two consecutive absences during the intervention phase or who choose to withdraw their consent to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-9dbk25m	ProMOVE Healthy Schools: Technologies for strengthening and integrating public policies for health promotion and integral education	Not yet recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7884	Health-Promoting Schools: Technologies for strengthening and integrating public policies for health promotion and integral education	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-07	Centro de Ciências da Saúde	Secretaria Municipal de Educação, Prefeitura de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-9dbk25m	<NULL>	Be a student at Full-Time Municipal Schools in Fortaleza, the capital of Ceará, Northeast Brazil; Be of both sexes; Be enrolled in the 6th to 9th grade of Elementary School; Be at least 10 years old; Agree to participate in the research	Do not fill out the questionnaire; Withdrawing from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-7w3g2b3	The cognitive effect of using Instagram vs. TikTok	Not yet recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7885	Comparison of the cognitive impacts of Instagram versus TikTok use among adolescents from different socioeconomic levels	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-30	Universidade Federal da Bahia - Faculdade de Medicina	Universidade Federal da Bahia - Faculdade de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-7w3g2b3	<NULL>	Adolescent users of Instagram and TikTok for at least 6 months from the date of the first test administration; adolescents of Brazilian nationality; between 13 and 18 years old; of both sexes	Adolescents who do not use TikTok and Instagram; adolescents who started using Instagram and TikTok less than 6 months ago from the date of the first test administration; adolescents who are not Brazilian; younger than 13 and older than 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-563rqd9	Chronic effects of motor rehabilitation in Stroke survivors through Resistance Training and Neuromodulation	Not yet recruiting	Intervention	2025-04-03	<NULL>	<NULL>	7887	Motor rehabilitation in Stroke survivors with severe functional impairments through Unilateral Eccentric Training combined with Cortical Neuromodulation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Instituto de Física Gleb Wataghin	Instituto de Física Gleb Wataghin	https://ensaiosclinicos.gov.br/rg/RBR-563rqd9	<NULL>	Patients who suffered a stroke (type 1) more than 6 months prior to participation in the study; patients who have severe hemeparesis as a consequence of the stroke; both female and male patients; patients above 18 years old	Patients who have any type of metal inside their body (pins, pacemakers, metal prostheses, revolver bullets); patients who have any musculoskeletal injury on the affected or unaffected limbs; patients who had previous conditions such as seizures, head trauma, hearing problems, and cochlear implants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-98yskk7	Effect of prior knowledge about a Caries-arresting product on caregivers&apos; opinion and acceptance regarding the appearance of children&apos;s primary teeth after use	Data analysis completed	Intervention	2025-04-02	<NULL>	<NULL>	7877	Influence of prior knowledge about a substance that arrests Caries on caregivers&apos; acceptance and impression regarding the appearance of its use on children&apos;s primary teeth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-98yskk7	<NULL>	Guardians and caregivers of children aged between 1 and 5 years; who are treated at the Clinic for Babies and Children in Early Childhood of the School of Dentistry of the Federal University of Rio de Janeiro; both sexes; who agree to participate in the study	Guardians and caregivers of children involved in clinical studies in which silver diamine fluoride was one of the investigated interventions; who had already been treated with silver diamine fluoride; those with visual impairments; who do not own smartphones	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-8y6cvnr	Breathing exercises to improve respiratory muscle strength and diaphragm movement in people with advanced chronic kidney disease who are not on dialysis	Recruiting	Intervention	2025-04-02	<NULL>	<NULL>	7878	Effects of an inspiratory muscle training protocol on respiratory muscle strength, thickness and diaphragmatic mobility of patients with Chronic Kidney Disease in the non-dialysis stage: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-08	Centro de Ciências da Saúde (CCS)	Centro de Ciências da Saúde (CCS)	https://ensaiosclinicos.gov.br/rg/RBR-8y6cvnr	<NULL>	Patients with a clinical diagnosis of Chronic Kidney Disease (CKD) in the non-dialytic stage, according to the criteria established by the National Kidney Foundation; aged between 40 and 70 years; male and female patients; clinically stable; without recent episodes of acute decompensation; capable of understanding and performing the maneuvers required for inspiratory muscle training (IMT).	Patients undergoing renal replacement therapy (hemodialysis; peritoneal dialysis; or kidney transplant); those presenting with acute or chronic respiratory diseases; neurological or musculoskeletal conditions that interfere with the performance of respiratory exercises; cognitive or behavioral incapacity that prevents participation in the study or adherence to the protocol instructions; or any other medical condition that renders the patient ineligible to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-7rrrvjw	Effects of recreational Volleyball program in Obese adolescents	Not yet recruiting	Intervention	2025-04-02	<NULL>	<NULL>	7880	Effects of a 12-week recreational Volleyball program in Obese adolescents: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Instituto de Educação Física e Esportes	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-7rrrvjw	<NULL>	Be between 12 and 17 years old; both genders; display body mass index &gt; 2 standard deviations above the specific for the age and se according to the World Health Organization reference medians; be in the final stages of the pubertal maturation	Have medical conditions that contraindicate participation in physical activities; the use of medication that influences the results observed; participation in structured exercise, nutrition or weight loss programs weight in the 6 months prior to the initial screening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-3t38hq2	Effect of a beam walking training on balance control during gait in older adults with a history of falls: a randomized clinical trial	Not yet recruiting	Intervention	2025-04-01	<NULL>	<NULL>	7874	Effect of beam walking training on dynamic balance control during locomotion in even and uneven terrains in older adults: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-07-01	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3t38hq2	<NULL>	Men and women; age between 65 and 80 years; intellectual capacity to understand verbal commands and perform tasks; ability to stand and walk independently without the use of assistive devices; older adults who have experienced at least one fall in the last six months; a MiniBEST test score below the cutoff point for fall risk, adjusted for age	Uncontrolled severe musculoskeletal, sensory, neurological, or cardiovascular problems; visual impairments not corrected by glasses or lenses; cognitive deficits such as alzheimer&apos;s, dementia, and other conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-10h3vtwm	Cardiovascular and sensory responses during Passive Ankle Movement in Elderly individuals	Not yet recruiting	Intervention	2025-04-01	<NULL>	<NULL>	7875	Cardiovascular and perceptual responses during Passive Ankle Mobilization in Elderly individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Hospital Israelita Albert Einstein	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-10h3vtwm	<NULL>	Both genders; age equal to or greater than 60 years; have no history of heart disease and do not have orthopedic problems; are not involved in the practice of regular systematic physical activity more than once a week over the last six months prior to the beginning of the study; do not have a body mass index greater than 30 kg/m2; have calf skinfold thicknesses of less than 20 mm due to the interference of adiposity in the penetration of light from the Near-infrared Spectroscopy (NIRS) probe; and are able to perform a passive ankle mobilization session	Participants who are smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-9wrq8n7	Effects of two types of Exercise on Breast Cncer	Not yet recruiting	Intervention	2025-03-31	<NULL>	<NULL>	7870	Acute effects of Exercise performed in two shorter sessions versus one longer session over the course of a day on Plasma Myokines, Growth and Viability of Mammary Carcinoma Lineage Cells: a Clinical, Randomized and Crossover Study with patients with Breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-08-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Hospital Imaculada Conceição	https://ensaiosclinicos.gov.br/rg/RBR-9wrq8n7	<NULL>	Woman; over 18 years of age; breast cancer patient undergoing radiotherapy; able to perform physical exercise according to medical evaluation	Have severe cardiovascular, metabolic or osteoarticular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-5qjhyk3	Influence of Non-invasive Electrostimulation using the Scalp Acupuncture technique on Hand Strength Potentiated by the Strength of the Opposite Finger	Not yet recruiting	Intervention	2025-03-31	<NULL>	<NULL>	7871	Influence of acute Non-invasive Cranial Electrostimulation using the Scalp Acupuncture technique on Overflow-potentiated Handgrip Strength	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-31	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5qjhyk3	<NULL>	Healthy volunteers; both sexes; age between 18 and 59 years; right motor preference; participants diagnosed with ischemic stroke on the left confirmed by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) scans; age between 40 and 79 years; right hemiparesis; minimum score of 50% on the Fugl Meyer scale	Left motor preference; orthopedic alterations; fear of needles; hemorrhagic tendencies; clinical instability; uncontrolled epileptic seizures; other associated neurological diseases; global aphasia; inability to understand the written and spoken portuguese language	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-2hs6h82	Manual and foam rolling myofascial release on muscle strength and balance in active adults with knee pain	Recruiting	Intervention	2025-03-31	<NULL>	<NULL>	7872	Contralateral effect of myofascial release performed manually and with foam rolling on neuromuscular responses in physically active adults with nonspecific patellofemoral pain.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-03	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-2hs6h82	<NULL>	Be free from functional limitations, except for nonspecific patellofemoral pain; must not present any type of limitation that could influence the experiment or the interpretation of the data obtained; not report any type of acute dizziness; men and women; aged between 18 and 59 years old	Exhibit abnormal fluid accumulation (edema); particularly in the lower limbs; present with severe visual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-79h7h7j	Metabolic effects of Melipona quadrifasciata propolis on glycemic, lipid, and oxidative stress profile	Terminated	Intervention	2025-03-31	<NULL>	<NULL>	7873	Metabolic effects of Melipona quadrifasciata propolis on glycemic and lipid profile, insulin resistance and oxidative stress markers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-15	Universidade Regional de Blumenau	Universidade Regional de Blumenau	https://ensaiosclinicos.gov.br/rg/RBR-79h7h7j	<NULL>	Subjects over 18 years of age from both genders who agree to participate by signing the informed consent form; answer questions from the anamnesis questionnaire and anthropometric data; make a daily intake of propolis extract or placebo during the study; and provide a sample of blood for biochemical measurements at the beginning and at the end of the study	Do not take a daily intake of of propolis extract or placebo during the study; not possible to obtain a blood sample for the biochemical measurements at the beginning and at the end of the study; presented as women pregnant or breastfeeding women; history of malabsorption or gastrointestinal surgery; cognitive problems that prevent them from understanding the instructions for participating in the study; participating in another clinical study at the same time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-3g2xxj2	Efficacy of Elastic Bandage on Pain and Quality of Movement in Patients with Knee Osteoarthritis	Not yet recruiting	Intervention	2025-03-26	<NULL>	<NULL>	7865	Efficacy of Tissue Flossing associated with Pilates on pain, function and quality of movement in patients with knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3g2xxj2	<NULL>	Patients aged between 40 and 80 years, of both sexes, diagnosed with symptomatic knee osteoarthritis; chronic degenerative joint condition with persistent symptoms for more than 12 weeks; not practicing physical activity regularly for more than 150 minutes per week; clinical diagnosis of knee osteoarthritis confirmed according to the criteria of the American College of Rheumatology, including knee pain associated with at least three of the following aspects: age equal to or greater than 50 years; crepitus during knee movements; increased sensitivity to compression; decreased local heat; bone enlargement; morning stiffness lasting less than 30 minutes; radiological changes from grade 2 onwards according to the Kellgren and Lawrence criteria, classified as follows: grade 0 – no changes; grade 1 – doubtful reduction of the joint space with possible presence of osteophytes; grade 2 – possibility of reduction of the joint space associated with the definitive presence of osteophytes; grade 3 – permanent reduction of the joint space, formation of osteophytes, subchondral sclerosis and deformity of the bone structures; grade 4 – large formation of osteophytes, severe reduction of the joint space, marked subchondral sclerosis and permanent deformity of the bone structures; presence of pain measured by the Numerical Pain Scale with a score equal to or greater than 3 points; painful passive range of motion in one or more osteokinematic movements of the knee complex	Patients with asymptomatic knee osteoarthritis; history of previous surgery in the lower limbs; presence of neurological or infectious disorders; severe visual impairments that compromise functionality or safety during the intervention; use of prostheses in the lower limbs; inability to understand the Portuguese language; having undergone physiotherapy treatment or Pilates in the last three months; administration of corticosteroids or hyaluronic acid in the last twelve months; presence of uncontrolled hypertension or diabetes; presence of peripheral vascular disease with a history of deep vein thrombosis, stroke, or any condition that contraindicates peripheral compression; presence of allergies or dermatitis that prevent the application of the proposed technique​	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-58j2jmh	Analysis of heart rate in people with spinal cord injury using two types of arm bicycles and physical tests and its relationship with general health. A controlled study	Not yet recruiting	Intervention	2025-03-26	<NULL>	<NULL>	7866	Analysis of heart rate variability between two types of Cycle ergometers and between functional submaximal tests and their correlation with health status in individuals with spinal cord injury - Randomized controlled clinical trial - Phase I	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-01	Departamento de Fisioterapia da Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-58j2jmh	<NULL>	Volunteers with spinal cord injury; both genders; aged between 18 and 50; neurological levels below the 6th spinal cord segment; complete or incomplete spinal cord injury; more than 6 months since injury; no regular physical activity; no physiotherapy	Volunteers with other associated neurological diseases; history of heart disease or lung disease; diagnostic hypothesis; who are unable to complete the tests for any reason such as withdrawal, hospitalization, infections, dermal, musculoskeletal, vascular or respiratory complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-7kp4x6p	Assessment of the superiority of using Bicalutamide 50 mg orally versus Spironolactone 100 mg orally for treatment of Female Baldness	Recruitment completed	Intervention	2025-03-26	<NULL>	<NULL>	7867	Assessment of the superiority of efficacy of using Bicalutamide 50 mg orally versus Spironolactone 100 mg orally for treatment of Female Pattern Alopecia: double-blind and randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-09-01	Clinica Sanabria Transplante e Restauração Capilar	Clinica Sanabria Transplante e Restauração Capilar	https://ensaiosclinicos.gov.br/rg/RBR-7kp4x6p	<NULL>	Females; age between 17 and 60 years; diagnosis of female pattern alopecia stages II to V of the Sinclair scale	Patients who have undergone previous treatment for hair loss in the last four months; diagnosed with high blood pressure, heart disease, liver disease or kidney disease; with other causes of hair loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-86fwwnn	Evaluation of a biotherapeutic as an adjunct treatment for Chronic Periodontitis	Recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7857	Double-blind, placebo-controlled pilot clinical study for clinical evaluation of biotherapeutic as an adjuvant to the treatment of Chronic Periodontitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-19	Universidade Veiga de Almeida	Universidade Veiga de Almeida	https://ensaiosclinicos.gov.br/rg/RBR-86fwwnn	<NULL>	The selected individuals must present a Clinical Attachment Level (CAL) of moderate severity, equal to or greater than three or four millimeters, and severe cases equal to or greater than five millimeters, according to the American Association of Periodontology classification. The probing depth must be present in at least two proximal sites of two non-adjacent teeth. Both sexes	Individuals who have undergone any periodontal treatment in the past twelve months. Presence of aggressive periodontitis. Pregnancy and lactation. Prosthesis users. Medical conditions that may interfere, such as HIV, diabetes, or chronic lung disease. Individuals treated with inhaled corticosteroids, nonsteroidal anti-inflammatory drugs, or antibiotics used in the past six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-39v9n67	Animal-Assisted Therapy in pediatric dentistry: an intervention study with dogs	Recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7858	Animal-Assisted Therapy in pediatric dentistry: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-13	Faculdade Meridional - IMED	Faculdade Meridional - IMED	https://ensaiosclinicos.gov.br/rg/RBR-39v9n67	<NULL>	Patients aged between 5 and 12 years; of both sexes; who require at least 2 restorative procedures and/or extractions under local anesthesia; who are in good general health; without significant medical conditions that would interfere with participation in the study, preventing the child from understanding and interacting with the animals	Patients with serious medical conditions; known phobia/aversion and allergies to dogs; and children with cognitive disabilities that may affect communication and understanding of instructions necessary to perform the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-2kpzdtb	Transcranial Magnetic Stimulation in two brain regions, insula compared to the motor area, in the treatment of Peripheral Neuropathic Pain and Migraine: a double-blind randomized clinical trial - superiority assessment	Recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7859	Transcranial Magnetic Stimulation of the posterior superior insula compared to the primary motor area (M1) in the treatment of Peripheral Neuropathic Pain and Migraine: a double-blind randomized clinical trial – superiority assessment	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-01-14	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2kpzdtb	<NULL>	18 years of age or older. Both gender. Ability to understand the study protocol and provide written informed consent. For patients with neuropathic pain, presence of peripheral neuropathic pain, according to current guidelines, with the following characteristics: Average pain intensity assessed by the Verbal Numeric Rating Scale  ≥ 4/10. Presence of neuropathic pain refractory to medication therapy. Persistent for more than six (6) months. For patients with migraine: Diagnosis of migraine with or without aura, according to the 3rd edition of the International Classification of Headache Disorders, in addition to the following characteristics: onset of migraine before 65 years of age, monthly frequency of headache days ≥4, absence of any secondary headache diagnosis, according to the 3rd edition of the International Classification of Headache Disorders, and no modifications to their migraine prophylactic treatment in the last 3 months	History of alcohol or illicit drug abuse. Severe uncompensated psychiatric comorbidities Comorbidities: Severe uncompensated medical comorbidities. Contraindications to rTMS, including cranial trauma or concussion, metallic implants in the skull, pregnancy, pacemaker, medication infusion devices, prior problems with TMS or MRI. Women of childbearing potential who are not using effective contraceptive methods. Other medical conditions that require hospitalization. Participation in other clinical trials at the same time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-7pghdmt	Postprandial effect of whole or ground flaxseed in people with type 2 Diabetes	Data analysis completed	Intervention	2025-03-24	<NULL>	<NULL>	7860	Acute effect of consumption of ground or whole flaxseed on blood glucose levels in people with type 2 diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Franciscana	Universidade Franciscana	https://ensaiosclinicos.gov.br/rg/RBR-7pghdmt	<NULL>	People diagnosed with type 2 Diabetes; both genders; adults aged 18 and over and elderly people without risk of dysphagia; who eats breakfast regularly (4 days a week, with an intake of 100 kcal within two hours of waking up); who like and commit to consuming the foods proposed in the study; and who have time available for the days planned for the research	Individuals diagnosed with another type of Diabetes mellitus; use of exogenous insulin; with decompensated Diabetes (capillary blood glucose 180 mg/dl on the day of the test); pregnant and breastfeeding women; depressive; smokers; alcoholics; with gastrointestinal disease; neurological; history of alcohol or drug abuse; that report the last bowel frequency according to the Bristol scale 1, 2, 5, 6 and 7; and allergic to the foods used in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-8pdy4q8	Effects of Transcranial Photobiomodulation Therapy in the rehabilitation of individuals up to three months after Stroke: a randomized clinical trial	Recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7861	Effects of Transcranial Photobiomodulation Therapy on the rehabilitation of individuals after Stroke: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-30	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8pdy4q8	<NULL>	Participants of both sexes; age between eighteen and fifty-nine years; up to three months from the episode of unilateral ischemic stroke; not neglecting paretic limbs; hemodynamically stable; without peripheral neuritis; able to understand and follow simple verbal instructions	Inability to understand questionnaires; hypersensitivity to light; oncological pathologies; infectious pathologies; post-surgical spinal procedures; rheumatic diseases; renal diseases; hepatic diseases; untreated gastrointestinal diseases; untreated psychiatric diseases; immunosuppression; pregnant women; lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-108r7p2n	The influence of prior information on the effect of caffeine on reaction time of university students	Not yet recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7862	The influence of caffeine on the reaction time of university students	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-06	Universidade Estadual do Sudoeste da Bahia	Universidade Estadual do Sudoeste da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-108r7p2n	<NULL>	university student; of both genders, that is, men and women; non-smoker; resident in the municipality of Jequié located in the state of Bahia; Brazil; over 18 years of age	volunteers who declare themselves to have diseases or use medications that interfere with movement or muscle activation and perception of visual and auditory stimuli; as well as individuals with upper limb amputations that make it impossible to handle and attach the reaction and strength measuring device	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-10365tqp	Pharmaceutical Care for patients with Leprosy	Not yet recruiting	Intervention	2025-03-24	<NULL>	<NULL>	7863	Implementation of the Pharmacotherapeutic Follow-up Service for Leprosy Patients in an outpatient pharmacy at a university hospital	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-06-02	Pro Reitoria de Pesquisa da Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-10365tqp	<NULL>	Patients with Leprosy treated at the Hospital das Clínicas of the Federal University of Minas Gerais; both genders; with no minimum or maximum age limit	Patients without Leprosy; patients with Leprosy not treated at the Hospital das Clínicas of the Federal University of Minas Gerais	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-10v56ctt	Comparison of the anxiolytic effect during dental anesthesia	Recruiting	Intervention	2025-03-20	<NULL>	<NULL>	7852	Comparison of the anxiolytic effect of Valerian officinalis l., Diazepam and Nitrous oxide during Dental anesthesia	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-08-12	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10v56ctt	<NULL>	Volunteers whose ages are between 18 and 40 years old; participants classified as ASA I; who have the upper 2nd molar used as a reference for application of the anesthetic technique	Patients under 18 or over 40 years of age will be excluded from the study; those weighing less than 50 kg or more than 90 kg; those who have never undergone anesthesia; those with a history of contraindications to the use of benzodiazepines or Valerian; and those with claustrophobia or mouth breathing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-45gqpmm	How LED Light Therapy Can Improve Brain Function in People with Fibromyalgia: A Scientific Study	Recruitment completed	Intervention	2025-03-20	<NULL>	<NULL>	7853	Effects of Systemic Photobiomodulation by LED therapy on cortical parameters in individuals with Fibromyalgia: randomized controlled study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal de Juiz de Fora - Campus GV	Universidade Federal de Juiz de Fora - Campus GV	https://ensaiosclinicos.gov.br/rg/RBR-45gqpmm	<NULL>	Adults of all genders; between eighteen and eighty years of age; with hearing acuity; no history of neuropsychiatric disorders; no self-reported use of psychoactive substances; diagnosed with fibromyalgia	Individuals with arthritis; lupus; any autoimmune disease; use of a pacemaker; practice of sports or physical activity; with an injury in the last six months; pregnancy; uncontrolled diabetes mellitus; uncontrolled blood pressure; malignant tumors; hypersensitivity to light	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-469x3sh	Multicenter study, before and after intervention, to test the end-of-life wishes card game in oncology residents and clinical oncologists	Not yet recruiting	Intervention	2025-03-20	<NULL>	<NULL>	7854	Awareness of oncology residents and clinical oncologists regarding the application of the Go Wish Cards Game for cancer patients: a multicenter pre and post-intervention study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-07	Hospital de Câncer de Barretos	Instituto Nacional do Câncer	https://ensaiosclinicos.gov.br/rg/RBR-469x3sh	<NULL>	Oncology residents; of both genders; being in the second or third year of clinical oncology residency; being available to participate in three sessions of the Go Wish card game intervention; and clinical oncologists	Oncology residents and clinical oncologists who have participated in previous studies involving the Go Wish Card Game	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-4knsh9z	Analysis of anxiety levels in third molar surgery comparing the use of Zolpidem and Passiflora incarnata: a controlled, randomized, triple-blind clinical study	Terminated	Intervention	2025-03-20	<NULL>	<NULL>	7855	Use of Zolpidem and Passiflora incarnata to control dental anxiety in third molar surgery: a controlled, randomized, triple-blind clinical study	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2021-10-20	Universidade Estadual Paulista Júlio de Mesquita Filho-Unesp	Universidade Estadual Paulista Júlio de Mesquita Filho-Unesp	https://ensaiosclinicos.gov.br/rg/RBR-4knsh9z	<NULL>	Patients in good systemic and local health conditions; both sexe; patients between 16 and 35 years of age; indication of extraction of third molars (elements 18, 28, 38 or 48), with at least 2/3 of the root formed, according to radiographic evaluation, thus belonging to classification I or II and position A or B of Pell and Gregory	Patients who have mandibular third molars in positions 3 and C according to the Pell and Gregory classification; presence of any local manifestations in the area of interest that may contraindicate the surgical procedure, such as: pericoronitis, cysts and odontogenic tumors associated or not with the third molar, trauma in the region, or any symptomatology that indicates the presence of infection; patients who smoke or who have some type of systemic disease (of any organic system), such as diabetes, systemic arterial hypertension, hyperthyroidism, osteoporosis, gastrointestinal diseases that compromise the results of surgery or that contraindicate the administration of the drugs used in the research; patients with a history of hypersensitivity to any drug used in the research; patients who are intolerant to other materials that will be used in the research, such as 0.5% alcoholic chlorhexidine solution, 0.12% chlorhexidine digluconate solution and 2% mepivacaine hydrochloride solution with epinephrine 1:100,000; female patients who are menstruating, gestational or lactating during the period of surgical procedures; patients who have an abnormal sleep pattern, who slept less than 5 hours the night before, or use medication to control psychiatric illnesses, or who are taking medication that interferes with cortisol analyses, such as corticosteroids, estrogens and androgens	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-2q3229w	Local Anesthesia for applying Hyaluronic Acid to the knee: does it make a difference?	Recruiting	Intervention	2025-03-20	<NULL>	<NULL>	7856	Decision for Subcutaneous Anesthesia to perform Intra-Articular Infiltration with Hyaluronic Acid in the knee	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-04-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2q3229w	<NULL>	Patients from the Sports Medicine outpatient clinic at the Federal University of São Paulo (UNIFESP); diagnosed with bilateral patellar chondropathy grade 3 or higher according to the International Cartilage Repair Society (ICRS); aged between 18 and 60 years; of both sexes	Patients under the age of 18 and above 60 years; patients with minor patellar chondropathy; patients with unilateral disease; patients with uncontrolled systemic diseases or immunosuppression; and patients who do not wish to participate or complete the stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-3hf6gyw	Aromaterapia inalatória com lavanda para redução da ansiedade	Recruitment completed	Intervention	2025-03-18	<NULL>	<NULL>	7845	Pilot study for clinical application protocol of inhaled aromatherapy with lavender for anxiety reduction: a randomized double-blind placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-08	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3hf6gyw	<NULL>	Age between 18 and 30 years; with an anxiogenic trait and medium anxiety state (with scores between 30 and 39 on the State-Trait Anxiety Inventory/ STAI); who smell odors.	Being chemically dependent, or using anxiolytics, antidepressants, antihistamines, narcotics; being allergic to odors/smells, or undertaking some other complementary therapy for stress/anxiety relief such as meditation or yoga; People who meet the diagnostic criteria for Generalized Anxiety Disorder, Obsessive Compulsive Disorder, Major Depressive Disorder and Attention Deficit Disorder, according to the Structured Clinical Interview for Disorders screening strategy of DSM-5.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-4hskt2d	Effects of a preoperative home exercise program: physical-functional and hospital outcomes in patients undergoing knee surgery	Not yet recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7847	Effects of a preoperative home exercise program: physical-functional and hospital outcomes in patients undergoing total knee arthroplasty	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-21	Ministério da Saúde	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	https://ensaiosclinicos.gov.br/rg/RBR-4hskt2d	<NULL>	Patients diagnosed with knee osteoarthritis who have been selected for total knee arthroplasty by their physician; both genders; aged between 50 and 75 years; who have signed the Free and Informed Consent Form; able to perform the exercises proposed in the home training program; availability for telerehabilitation sessions and WhatsApp for supervised video conferences	Patients who do not respond to scheduled telerehabilitation sessions or communication via WhatsApp; patients who present unexpected medical complications that prevent continuity or safety in the exercise program will be instructed to immediately stop exercising and excluded from the study; changes in the clinical condition that result in surgical contraindication or new injuries during the pre-rehabilitation period that make participation in home exercises unfeasible will also be grounds for exclusion; patients who present scores below the values ​​suggested by the Ministry of Health in the Mini Mental State Examination (MMSE) due to the possibility of inability to adequately understand the tests and the intervention protocol; are involved in another physical exercise program that has a frequency equal to or greater than once a week; have any other medical condition that prevents safe participation in the exercise program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-5s28jmt	Fascial Massage for the treatment of Muscle Pain in athletes: a randomized controlled clinical trial	Recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7848	Myofascial Release for the treatment of Musculoskeletal Pain in athletes: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-12	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5s28jmt	<NULL>	Athletes and sports practitioners with muscle pain related to physical exercise; physically active or very active; both genders	Athletes and sports practitioners with pain originating from musculoskeletal injury; unable to read and unable to answer questionnaires; non-sports practitioners	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-5sfkgpy	Cashew fiber in preventing obesity	Recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7849	Effect of Cashew Fiber (Anacardium occidentale L.) in the Prevention of Obesity: A Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-5sfkgpy	<NULL>	Healthy volunteers; body mass index between 25 and 29.9 kg/m²; age range between 20 and 39 years; non-smokers; non-alcoholics; both sexes	With comorbidities and/or complications such as kidney, liver, severe cardiovascular and gastrointestinal diseases; who use continuous medications (except contraceptives); allergy to any food ingredient used; women who are pregnant or lactating; individuals who drink alcohol or smoke; people who take fiber supplements or undergo weight loss treatments; individuals who perform moderate or high intensity physical activity for more than 30 minutes daily; individuals who present cognitive alterations, such as psychotic disorder resulting from a general medical condition and/or induced by substances, Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, Brief Psychotic Disorder, Delusional Disorder and Psychotic Disorder without specification	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-3njbh7w	Effects of Acupuncture on the scalp for pain relief, depression symptoms and impact on improving the quality of life of people with Fibromyalgia	Not yet recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7850	Effects of Craniopuncture on pain, depression symptoms, and impact on quality of life of people with Fibromyalgia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-03	Programa de Pós-Graduação em Enfermagem da  Universidade Federal do Rio Grande do Norte	Programa de Pós-Graduação em Enfermagem da  Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3njbh7w	<NULL>	Patients with a diagnosis of fibromyalgia obtained through the International Classification of Diseases (ICD-10) code M79 will be included. 7; patients aged 18 years or older; both sexes	Individuals with impaired cognitive ability, who are unable to understand the questions in the questionnaires; those who have other causes of pain; those who have an insurmountable fear of needles	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-34qpgjn	The benefits of Physical Exercise and Blood Molecular Analysis as an intervention for reducing Kidney Toxins in patients with Chronic Kidney Disease: an exploratory study	Not yet recruiting	Intervention	2025-03-18	<NULL>	<NULL>	7851	The benefits of Physical Exercise and Biomolecular analyses as an intervention to reduce Uremic Toxins in patients with Chronic Kidney Disease: an exploratory study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-10	Strictu Sensu em Educação Fìsica	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-34qpgjn	<NULL>	Person diagnosed with chronic kidney disease and who have persistent albuminuria (&gt;300mg/g) following the KDIGO - Kidney Disease: Improving Global Outcomes guidelines; metabolic syndrome {i.e., type 2 diabetes mellitus, arterial hypertension (blood pressure&gt;180/100mmHg), overweight or obesity, and dyslipidemia}; do not have complications arising from preexisting clinical metabolic diseases (i.e., diabetic coma, ketoacidosis, hyperosmolarity, and/or uncontrolled diabetes), evaluated by a nephrologist; absence of neurodegenerative, osteomyoarticular diseases, lupus erythematosus, or congenital kidney disease; do not have apparent cardiovascular complications, such as heart failure, severe arrhythmia, angina, or cerebrovascular disease; do not have comorbidities that limit performance in physical tests or training; have not been engaged in physical exercise programs for at least six months prior to the start of the experimental protocol; have no smoking or alcohol consumption behavior; D-dimer values ​​within normal values ​​(220-500 ng/mL); patients of both sexes; and over 18 years of age	Practice physical exercise regularly; have suffered a stroke in the last 6 months and/or have autoimmune diseases; unstable cardiac dysfunctions, such as: non-stabilized coronary disease, aneurysm at risk of rupture, uncontrolled arrhythmia, uncontrolled hypertension (SystolicBloodPressure&gt; 190 mmHg and/or DiastolicBloodPressure&gt; 100 mmHg); infarction in the last 3 months;  infectious conditions, Hemoglobin lower than 8 in the last monthly routine hemodialysis exam; myoarticular pain; fever;  oxygen saturation (SpO2) at rest less than 94%; restriction of clinical staff will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-5wfcmwv	Application of artificial intelligence in the design of single crowns on implants in the anterior region	Recruiting	Observational	2025-03-17	<NULL>	<NULL>	7838	Design of single crowns on implant in anterior region by artificial intelligence	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-16	departamento de odontologia	Departamento de Engenharia de Computação e Automação	https://ensaiosclinicos.gov.br/rg/RBR-5wfcmwv	<NULL>	Individuals over 18 years of age; of both sexes; with stable occlusion; with all upper and lower anterior teeth aligned and healthy or with single-sided restorations that do not alter their morphology. For the second stage of training, models with a trunnion-type abutment in the anterior region of the maxilla and their respective antagonist models will be selected from the Laboratory database in dental prosthetics	Individuals with missing anterior teeth; undergoing orthodontic treatment or with pathological tooth migration resulting from periodontal disease will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-57vgbmg	The Cognitive Functional Therapy in foot disorders	Recruiting	Intervention	2025-03-17	<NULL>	<NULL>	7839	Effectiveness of Cognitive Functional Therapy in patients with Plantar Fasciopathy: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-24	Departamento de Ciências do Movimento Humano	Centro Universitário Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-57vgbmg	<NULL>	Participants of both sexes; aged 18 years or older; with complaints of plantar pain greater than or equal to 3 out of 10 points on the numerical pain scale for at least 3 months; reproduced with the first step in the morning and/or in activities with increased weight support, for example, standing; pain on palpation of the medial calcaneal tubercle and/or proximal plantar fascia will be included in the study; Patients who present with bilateral pain will be considered on the side with greater pain	Participants who have had musculoskeletal disease in the lower limbs in the last 6 months; systemic musculoskeletal disease; previous surgery on the lower limbs and spine; diabetes; pregnancy; having received corticosteroid application in the plantar fascia in the last 6 months will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-3gj96xw	Comfort and usability of customized mouthguards obtained by conventional molding and through an intraoral scanner and 3D printers: randomized clinical trial	Recruitment completed	Intervention	2025-03-17	<NULL>	<NULL>	7840	Comfort and usability of personalized mouthguards obtained by conventional and digital flow impressions: a randomized, parallel-arm clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-06-01	Faculdade de Odontologia Universidade Federal de Uberlândia	Hospital Odontológico da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3gj96xw	<NULL>	Young and adult athletes of both genders; over 16 years of age; with sufficient critical ability to answer the questionnaire objectively; who regularly practice some sport at least twice a week and who agree to use a mouthguard in all sports activities; patient who has a medical history that does not compromise the evolution of results; who has the habit of brushing their teeth at least twice a day; who has posterior occlusal stability and who has a normal periodontal condition according to probing parameters	Athletes of both genders; who have recently suffered a dentoalveolar trauma and are in pain; who have a recent root, alveolar or condylar fracture; who need dental retention; who have some chronic disease with oral manifestations; who have some oral pathology considered serious; patients with very poor oral hygiene; patients with occlusal instability; patients with advanced periodontal disease; patients with allergies to any material that will be used at work	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-5w2fsx4	Pulp Therapy with Two Antibiotic Pastes - Randomized Clinical Trial	Recruiting	Intervention	2025-03-17	<NULL>	<NULL>	7841	Non-Instrumental Technique with two Antibiotic Pastes - Randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-01-06	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-5w2fsx4	<NULL>	Children of both sexes; aged 3 to 7 years; who have lower deciduous molars with a clinical and radiographic diagnosis of irreversible pulpitis or pulp necrosis; physiological root resorption equal to or less than 1/2 and sufficient dental structure for absolute isolation of the operating field and adaptation of a steel crown	Children with teeth with calcific metamorphosis; pathological internal or external root resorption visible on periapical radiographs; history of allergic reaction to toothpaste components; use of antibiotics in the month prior to treatment and immunocompromised children	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-4fcb4z4	Effectiveness of Tai Chi on patients with Chronic Neck Pain	Not yet recruiting	Intervention	2025-03-17	<NULL>	<NULL>	7842	Effectiveness of Tai Chi in patients with Nonspecific Chronic Neck Pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fcb4z4	<NULL>	Chronic nonspecific neck pain (defined as pain and discomfort) located in the neck region between the upper nuchal line and the scapular level for at least three months; age between 18 and 80 years; men and women may be included in the study; present pain intensity of at least three points on the numerical pain scale; reside in the region where the study will be conducted; the selected subjects will have to present sufficient knowledge of the Portuguese language to be able to answer the questionnaires	suspected or confirmed spinal diseases (e.g. tumor, infection, and fractures); history of spinal surgery; cardiovascular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-10hxhyfp	Technology Method in Postural Education for Schoolchildren and Teachers	Not yet recruiting	Intervention	2025-03-17	<NULL>	<NULL>	7843	Technology in Postural Education (TEP): Method for Approach of Students and Teachers	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-03-15	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10hxhyfp	<NULL>	Teachers of both sexes and different subjects from participating schools. Children and adolescents of both sexes, aged between 8 and 17 years old. Enrolled in and attending public and private schools in the city of Florianópolis, Santa Catarina. Literate students, with reading and writing skills. Individuals with access to the internet and an electronic device, such as cell phone, tablet, computer, notebook. Teachers and students whose parents and/or guardians sign the Free and Consent Form Informed (TCLE), Consent Form for Photographs, Videos and Recordings, students who sign the Consent Form	Students with motor and cognitive disabilities, previously acquired physical disabilities, congenital and neurological disorders. Students who do not attend 70% of the program&apos;s classes. Teachers who do not attend training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-9j64v4y	Effect of Platelet-Rich Fibrin (PRF) on Post Tonsil Surgery Pain	Recruitment completed	Intervention	2025-03-17	<NULL>	<NULL>	7844	Effect of Platelet-Rich Fibrin (PRF) on Post-Tonsillectomy Pain	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2024-11-01	Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	https://ensaiosclinicos.gov.br/rg/RBR-9j64v4y	<NULL>	Age equal to or over 18 years old. Indication for tonsillectomy. Signing of the Free and Informed Consent Form (ICF). Both sexes	Refusal to sign the Informed Consent Form (ICF)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-8psxvsq	The effect of Laser Acupuncture and Strength Exercises on the pain and function of knee osteoarthritis in the elderly: a controlled, experimental and double-blind clinical trial	Not yet recruiting	Intervention	2025-03-12	<NULL>	<NULL>	7834	The effect of Laser Acupuncture and Progressive Resistance Exercises on pain and function of knee osteoarthritis in the elderly: a controlled, randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-06	Universidade Federal de São Paulo	Secretaria Municipal de Saúde de Santos	https://ensaiosclinicos.gov.br/rg/RBR-8psxvsq	<NULL>	Individuals of both sexes; aged 60 years and over; diagnosed with knee osteoarthritis according to the criteria of the American College of Rheumatology; experiencing knee pain between 3 and 8 on the numeric pain scale (NDS) in the last week	Use of metal prosthesis in the hip or knee region; cardiac pacemaker or other electronic implants; peripheral neurological deficit; uncontrolled systemic arterial hypertension; uncontrolled diabetes mellitus; continuous use of anti-inflammatories; steroid use; thrombotic or embolic changes in blood vessels; joint infiltration in the knee in the last 3 months; regular physical activity at the time of the research and any medical condition that prevents physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-74w5bt4	Evaluation of the effect of different methods of topical anesthesia during the anesthesia procedure before dental treatment in children requiring treatment of primary molar teeth	Recruitment completed	Intervention	2025-03-12	<NULL>	<NULL>	7835	Evaluation of the effect of different methods of topical anesthesia on pain during infiltrative anesthetic puncture in children requiring dental treatment of primary molars: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-20	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-74w5bt4	<NULL>	Children aged 6 to 9 years; without systemic impairment (information provided by guardians); ASA I and II; of both sexes; with or without experience in dental care; who need dental treatment on lower deciduous molars, under local anesthesia, including restorations with absolute isolation, endodontic treatment or extraction; patients who will be referred for care at the Supervised Internship for Children and Adolescents (ESCA) clinic, a discipline linked to the undergraduate clinic in Dentistry at the Federal University of Santa Catarina (UFSC)	Patients with odontogenic infection associated with systemic signs and symptoms; acute pain or dental urgency; reported history of allergy to drugs used in the research (topical anesthesia and anesthetic solution) or components of absolute isolation (in cases requiring restorative or endodontic treatment); reported history of respiratory disease; reported history of hemorrhage or problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-9tt6s3p	The effect of Cat&apos;s Claw on inflammation, pain, and quality of life in women with endometriosis	Not yet recruiting	Intervention	2025-03-11	<NULL>	<NULL>	7828	Effect of Uncaria Tomentosa Supplementation on Markers of Inflammation and Oxidative Stress, Pain, and Quality of Life in Women with Endometriosis: A Randomized, TripleBlind, Placebo-Controlled Clinical Trial	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9tt6s3p	<NULL>	Adult women; between 18 and 49 years old; with symptomatic Endometriosis; diagnosed through laparoscopy and/or magnetic resonance imaging and/or transvaginal ultrasound with bowel preparation; with rejection of hormonal treatment, at least in the last 3 months	Women diagnosed with Endometriosis who are pregnant and/or lactating; are allergic to the Uncaria tomentosa plant; who have liver diseases such as hepatitis, gallstones, liver cirrhosis and hepatic steatosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-59ytd4c	Prolotherapy: An Alternative for Knee Osteoarthritis	Recruitment completed	Intervention	2025-03-11	<NULL>	<NULL>	7829	Prolotherapy in the treatment of knee osteoarthritis	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-03-19	Instituto Nacional de Traumatologia e Ortopedia	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-59ytd4c	<NULL>	Patients aged between 40 and 75 years. Both sexes. Diagnosis of bilateral knee osteoarthritis according to the criteria of the American College of Rheumatology. Classified by radiographs using the Kellgren-Lawrence classification of grade III or less in both knees. Presenting with a full range of motion	Patients with a history of trauma, infection, or previous surgery in the affected joint. Patients with an alteration of the mechanical axis measurement of the lower limbs, varus or valgus greater than 5 degrees. Patients with inflammatory diseases. Corticosteroid infiltration in the last 6 weeks. Patients who underwent viscosupplementation in the past year. Patients who used NSAIDs in the two weeks prior. Patients with a body mass index greater than 40. Patients with a history of allergy to pollen or bird-derived products. Patients with active neoplasia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-5z98vxb	Effects of different rehabilitation protocols in adults and elderly individuals with chronic post-Chikungunya joint pain	Not yet recruiting	Intervention	2025-03-11	<NULL>	<NULL>	7831	Efficacy of different rehabilitation protocols on biopsychosocial variables in adults and elderly people with chronic post-Chikungunya arthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5z98vxb	<NULL>	Individuals infected with the Chikungunya virus with chronic arthralgic symptoms (more than 3 months); pain level more than 0 on Visual Analogical Scale; of both sexes; aged over 18 years old	Individuals who present any contraindication to the proposed interventions; who do not respond to simple commands; who present arthralgic symptoms of origin other than Chikungunya virus infection; who are carrying out other physical treatment protocols or begin during the intervention; who use wheelchair-type walking aids or bedridden individuals who have some severe comorbidity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-10bfs3gm	Effects of Sports Training associated with Nutritional Intervention on adolescent health	Not yet recruiting	Intervention	2025-03-11	<NULL>	<NULL>	7832	Effects of Sports Training associated with Nutritional Counseling on cardiovascular risk factors in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-15	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-10bfs3gm	<NULL>	Adolescents of both sexes; aged between 11 and 14; residing in Porto Alegre - RS and the metropolitan region; available to participate on determined days and times	Adolescents with any pathology or injury that limits the total or partial execution of the training protocol; using medications that influence the results (for example: statins, hypoglycemic agents or beta-blockers); pregnancy; who have been participating in some physical activity/exercise or following some nutritional counseling program for at least six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-8mwt64p	Effect of Ozone Gas on Abdomen Fat	Recruitment completed	Intervention	2025-03-11	<NULL>	<NULL>	7833	Evaluation of the effects of Ozone Therapy in the treatment of Fat Located in the region of abdomen	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-20	Centro Universitário das Faculdades Associadas de Ensino - FAE	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-8mwt64p	<NULL>	Female, aged 18 to 65 years old;  with a body mass index considered eutrophic and/or overweight;  carriers of superficial subcutaneous adipose tissue, such as: localized fat greater than 1.5 cm and cellulite of different degrees; non-smokers;  who agree to participate and sign the TCLE.	"Pregnant women; Patients who have G6PD deficiency;  Age under 18 or over 65; With facial and/or body plastic surgeries in the treatment area; Using home-care dermocosmetics, or other dermatological procedures;  Patients with hemophilia and bleeding disorders;  People with diabetes mellitus and decompensated metabolic disorders; Underwent aesthetic treatment in the treatment region in the last 3 months; Skin lesions, such as dermatitis and dermatoses; Dancerous lesions on or near the area; Participants with a cardiac pacemaker or other implanted electronic device;  Who refuse to sign the free and informed consent form. 
Who miss two consecutive treatments or who start some type of anti-inflammatory treatment or use of dermocosmetics during the study"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-36z72x9	Comparison between Restorations with stainless steel crowns and orthodontic bands: randomized controlled clinical trial	Recruiting	Intervention	2025-03-10	<NULL>	<NULL>	7824	Restorations with stainless steel crowns versus orthodontic bands: randomized controlled clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-29	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-36z72x9	<NULL>	Children aged three to eight years old; of both sexes; treated at the pediatric dentistry clinic of the Federal University of Piauí - UFPI who have deciduous molars with extensive carious lesions on occlusoproximal surfaces, without pulp involvement; the teeth must have sufficient remaining structure for adaptation of a stainless steel crown or orthodontic band	Molars with mobility, pain or symptoms of pulp pathology; gingival inflammation caused by poor oral hygiene	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-3h369zf	Impact of immediate breast reconstruction on time to start chemotherapy and radiotherapy after mastectomy	Recruitment completed	Observational	2025-03-10	<NULL>	<NULL>	7825	Impact of immediate implant-based breast reconstruction on integration of chemotherapy and radiotherapy post-mastectomy: a retrospective cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-01-01	Hospital Aristides Maltez	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3h369zf	<NULL>	Women aged 18 years or older; diagnosis of invasive breast carcinoma treated at Aristides Maltez Hospital; clinical staging I, II and III according to the American Joint Committee on Cancer 8th edition; patients undergoing mastectomy only; patients undergoing any type of mastectomy only and mastectomy associated with immediate implant-based breast reconstruction	Diagnosis of local and regional recurrence and distant metastases of breast cancer; diagnosis of de novo stage IV; inflammatory carcinoma; first adjuvant therapy not performed at Aristides Maltez Hospital; prophylactic mastectomy; incomplete neoadjuvant chemotherapy up to the time of mastectomy; tumor progression or clinical non-response to neoadjuvant chemotherapy; bilateral mastectomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-39xwyzr	Educational action for adults with type 2 Diabetes in primary care with a low-carbohydrate diet	Recruitment completed	Intervention	2025-03-10	<NULL>	<NULL>	7826	Educational intervention for adults with type 2 Diabetes in primary care on low-carbohydrate eating:a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-15	Universidade Estadual do Oeste do Paraná	Prefeitura Municipal de Francisco Beltrão	https://ensaiosclinicos.gov.br/rg/RBR-39xwyzr	<NULL>	Patients diagnosed with Type 2 Diabetes without using insulin, aged between 40 and 89 years and with glycated hemoglobin levels equal to or above 6.5%. It may or may not have arterial hypertension as a comorbidity. Must have full access to the internet and have a smartphone application for individual or group communication	Those who have other forms of Diabetes, vegans, vegetarians, who have had bariatric surgery, with severe cardiovascular disease or diagnosed kidney disease, with a condition that affects their ability to participate, pregnant and lactating women, being on a weight loss program, in risk of an eating disorder or with a baseline glycated hemoglobin measurement of less than 6.5%	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-8xz3t35	How macronutrients affect Skin Temperature in para-athletes: a crossover study with Infrared Thermography	Data analysis completed	Intervention	2025-03-10	<NULL>	<NULL>	7827	Effect of the influence of meals with different macronutrient compositions on the thermographic response at rest and post-exertion in paralympic athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Escola de Educação Física da Universidade Federal de Minas Gerais	Escola de Educação Física da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8xz3t35	<NULL>	Athletes from the competitive teams of the Paralympic sports of para-taekwondo, powerlifting, swimming, and athletics at the Brazilian Paralympic Reference Center of Universidade Federal de Minas Gerais; individuals aged between 18 and 50 years; athletes who have participated in state, national, or international competitions in the past year; and those who have an eligible impairment to compete in the mentioned Paralympic sports; both sexes	Individuals under 18 years of age or over 50 years; those who have not participated in state, national, or international competitions in the past year; athletes with food allergies or intolerances that prevent participation in the proposed nutritional interventions; individuals with inflammatory processes or muscle injuries in the last two months; participants with a history of severe and disabling injuries that prevent them from regular training; and athletes who do not have an eligible impairment to compete in Paralympic sports	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-3rxj6y6	The effect of sense of coherence on the quality of life of adolescents after COVID-19 pandemic: experimental study	Recruitment completed	Intervention	2025-03-10	<NULL>	<NULL>	8142	Sense of coherence and its effect on the health and quality of life of vulnerable adolescents after the COVID-19 pandemic:  intervention study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-18	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3rxj6y6	<NULL>	Students must be enrolled in their first or second year of high school and be 15 or 16 years old at the time of the survey. Both sexes	Adolescents using orthodontic appliances. Pregnant or breastfeeding students	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-8b3rrkq	How vacuum drainage can help treat dental infections: a patient study	Recruitment completed	Intervention	2025-03-07	<NULL>	<NULL>	7820	Use of vacuum drainage in odontogenic infections: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Hospital Metropolitano Odilon Behrens	https://ensaiosclinicos.gov.br/rg/RBR-8b3rrkq	<NULL>	Patients over 18 years of age; both sexes;  hospitalized due to severe odontogenic infection and with indication of extraoral drainage in primary facial spaces: buccal, submandibular and/or submental; Such patients must be classified by the American Anesthesiology Association (ASA), as ASA I - good general health or ASA II - compensated underlying disease	Patients with a history of hypersensitivity to any of the components of the medications used; patients classified as American Association of Anesthesiology - ASA III or ASA IV; patients with tuberculosis, collagen vascular diseases, multiple sclerosis, Human Immunodeficiency Virus (HIV) infection, and other autoimmune diseases; pregnant and breastfeeding women; patients with cognitive disorders that make it impossible to understand and execute commands; withdrawal of consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-4w7tkh3	Study on the efficacy and safety of a nanotechnology product based on Rosemary essential oil with Ultrasound application in patients with knee Osteoarthritis	Not yet recruiting	Intervention	2025-03-07	<NULL>	<NULL>	7821	Efficacy and safety of Phonophoresis with Salvia Rosmarinus essential oil nanoemulsion in knee Osteoarthritis: a randomized, triple-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-01	Empresa Brasileira de Serviços Hospitalares	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4w7tkh3	<NULL>	Clinical and radiological diagnosis of knee osteoarthritis according to the American College of Rheumatology criteria. Age 18 years or older. Both sexes. Ability to understand and sign the Informed Consent Form. Presence of knee pain for at least three months impacting functionality. Availability to attend study sessions throughout the intervention period	Previous diagnosis of rheumatoid arthritis, gouty arthritis, infectious arthritis, or other inflammatory joint diseases. History of prior surgery on the affected knee. Use of oral or intra-articular corticosteroids in the last six months. Presence of ulcers, skin infections, or lesions in the intervention application area. Severe neurological or psychiatric diseases that may compromise study participation. Pregnancy or lactation. Use of metallic devices in the knee preventing phonophoresis application. Participation in another clinical trial in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-10rz4v48	Evaluation of teeth restored with full crowns using 3D printed resin and milled national restorative materials	Recruiting	Intervention	2025-03-07	<NULL>	<NULL>	7822	Prospective clinical study of anterior and posterior teeth rehabilitated with 3D printed and/or milled resin full crowns using national restorative materials	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-26	Universidade Federal de Uberlândia Faculdade de Odontologia	FGM Dental Group	https://ensaiosclinicos.gov.br/rg/RBR-10rz4v48	<NULL>	Adult patients over the age of 18; both genders;  in need of restoration in anterior and/or posterior teeth with severe coronal destruction; patients with a medical history that does not compromise the evolution of the results; who have the habit of brushing their teeth at least once a day and who have normal periodontal condition in relation to probing parameters	Patients with any chronic disease with oral manifestations; who have any oral pathology considered serious; patients with periodontal disease; presence of periapical lesions; patients with allergies to any material that will be used in the work	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-4fht8tn	Gamified educational strategy for preventing bullying and cyberbullying with school adolescents	Recruitment completed	Intervention	2025-03-07	<NULL>	<NULL>	7823	Motivational effects of digital game-based learning for education in bullying prevention measures	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Centro de Ciências da Saúde	Centro de Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-4fht8tn	<NULL>	Adolescents aged 10 to 14; Be regularly enrolled in the 6th to 9th year of elementary education II of selected school; Have basic conceptual knowledge about bullying and cyberbullying in order to minimize the occurrence of errors in the semantic evaluation of the Measurement Scale Intention to Prevent Bullying and Cyberbullying; Adolescents self-declared between different gender identities	Students who were drawn but were not present at school at the time filling out the data collection form; Adolescents with cognitive problems related to difficulty in understanding that made filling out the forms difficult; Adolescents with hearing, visual impairment or special needs which made it difficult to evaluate the proposed educational tool	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-7rtnwfr	Evaluation of the sedative effects of Dexmedetomidine after anesthesia for gallbladder removal	Recruiting	Intervention	2025-03-06	<NULL>	<NULL>	7817	Effects of Dexmedetomidine on awakening from anesthesia in patients undergoing videolaparoscopic surgery: randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-11-01	Faculdade de Ciências Médicas de Pernambuco	Complexo Hospitalar do Hospital Universitário Oswaldo Cruz da Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7rtnwfr	<NULL>	Patients of both sexes; candidates for cholecystectomy; no chronic or serious illnesses; with mild or controlled systemic diseases, without functional limitations	Pregnant women; known allergy to the drugs used in the study; bradycardia with a heart rate below 50 bpm; preoperative cardiac conduction block; kidney or liver failure; decompensated psychiatric disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-3dvy84p	Effects of the muscle relaxant Cyclobenzaprine on the chewing muscles activity during sleep	Recruiting	Intervention	2025-03-06	<NULL>	<NULL>	7818	Effects of Cyclobenzaprine on rhythmic masticatory muscle activity during sleep: proof of concept for a randomized placebo-controlled crossover trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-01-02	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3dvy84p	<NULL>	Volunteers of both sexes; age between 18 and 50 years; self-reported teeth clenching and/or grinding during sleep (at least once a week in the last month) or sleep partner or family-reported clenching and/or grinding in the past 3 months; dental wear compatible with possible sleep bruxism, based on clinical evaluation; secondary manifestations related to sleep bruxism, such as discomfort/tension/facial pain (excluding persistent headache or migraine), temporal headache, or jaw locking upon waking; frequent history of tooth or restoration fracture; clinical signs of tongue mucosa indentation and masseter muscle hypertrophy	History of dizziness and syncope; sensitivity to drowsiness induced by alcohol and medications such as muscle relaxants and anxiolytics; history of any type of heart disease, such as tachycardia, arrhythmia, heart failure, and myocardial infarction; diagnosis of obstructive sleep apnea-hypopnea syndrome, periodic limb movement disorder, and insomnia; liver dysfunction; diagnosis of hyperthyroidism or hypothyroidism; pregnancy or suspected pregnancy, postpartum and breastfeeding, as well as the use of oral contraceptives and/or other related methods; use of anxiolytics, antidepressants, sleep inducers, analgesics, and monoamine oxidase inhibitors in the last 14 days; history of cannabis use; report of persistent intense headaches, migraines, facial pain, and temporomandibular joint pain that interfere with daily activities; limited mouth opening of less than 25 mm; history of allergy to electrode gel adhesive; history of severe and persistent gastroesophageal reflux​	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-4433szt	What is the best surgical treatment for trigger finger? Minimally invasive technique with retinaculotome or open technique	Not yet recruiting	Intervention	2025-03-05	<NULL>	<NULL>	7816	Surgical treatment of trigger finger: minimally invasive technique with retinaculotome versus open technique. Randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-25	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4433szt	<NULL>	Trigger finger in any of the five fingers; over 18 years old; both sexes; trigger finger greater than II according to the green classification.	Associated Dupuytren&apos;s disease; previous surgical treatment for trigger finger; patients with associated collagen or autoimmune diseases; presence of joint stiffness in the interphalangeal joints; previous tendon injuries or fractures of the metacarpals or phalanges	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-79gtzqq	Laser treatment for healing after tooth extraction in patients who received radiotherapy for head and neck cancer - clinical trial	Recruitment completed	Intervention	2025-02-28	<NULL>	<NULL>	7813	Use of photodynamic therapy in alveolar repair after tooth extraction in head and neck irradiated patients: randomized clinical trial	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2023-04-01	Sociedade Pèrnambucana de Combate ao Câncer	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-79gtzqq	<NULL>	Over 18 years old; both genders; presence of teeth with indication of simple extraction; history of radiation therapy to the head and neck; more than 3 months from the end of radiotherapy to the head and neck	Patients who underwent palliative radiotherapy or with any dose lower than 60Gy; patients who have used medications with antiresorptive potential or other cause likely to cause bone necrosis; patients with any known contraindication or allergy to methylene blue or some  prescribed medications; patients whose Radiotherapy has not involved the region in which the tooth to be removed is included; patients with some clinical impediment to photobiomodulation (trismus, surgical sequelae)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-5vxncn2	Use of ozone for tooth whitening in patients with tooth sensitivity: clinical and randomized study	Not yet recruiting	Intervention	2025-02-28	<NULL>	<NULL>	7814	Use of medicinal ozone for tooth whitening in patients with tooth hypersensitivity: clinical and randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-20	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5vxncn2	<NULL>	Patients of both sexes will be included in the study; aged between 18 and 35 years; with all vital anterior teeth; never whitened or restored; with periodontal health; no history of spontaneous dental pain; that do not use toothpaste with desensitizing properties; with grade 1 to 3 dentin sensitivity;  willing to return for future evaluations during the research period	Patients with missing anterior teeth will be excluded from the study; affected by caries lesions; with the presence of recession; with some type of restorative or prosthetic treatment; or who use fixed orthodontic appliances; patients with bruxism or visible enamel cracks; patients with a history of periodontal disease or active periodontal disease; patients with a history of dental hypersensitivity; patients with tooth color changes due to fluorosis or tetracycline; patients who use many medications; and pregnant or lactating patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-3m77djm	Feasibility and effectiveness of a pre-operative home physical exercise Program in Osteoarthritis patients awaiting knee prosthesis Surgery	Not yet recruiting	Intervention	2025-02-28	<NULL>	<NULL>	7815	Feasibility and effectiveness of a physical exercise Program pre-operative homework in Osteoarthritis patients waiting for total knee Arthroplasty	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-28	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad - INTO	https://ensaiosclinicos.gov.br/rg/RBR-3m77djm	<NULL>	Participants eligible for the study will be those aged between 50 and 75 years; of both sexes; who report being able to perform the proposed exercises (table 1); who accept the terms of the informed consent form (ICF); who are not engaged in another physical exercise program; who do not present cardiovascular, metabolic, or musculoskeletal conditions unrelated to knee osteoarthritis that may prevent the execution of the evaluation tests and the home exercise program; who present a diagnosis of unilateral knee osteoarthritis according to the Ahlbäck classification modified by Keyes et al. (1992), being grade I reduction of joint space or grade II obliteration of joint space or grade III wear of the tibial plateau &lt; 5 mm in the anteroposterior plane and intact posterior part of the plateau in the sagittal section or grade IV wear of the tibial plateau from 5 to 10 mm in the anteroposterior plane and extensive wear of the posterior margin of the tibial plateau in the sagittal section or grade V severe subluxation of the tibia in the anteroposterior plane and anterior subluxation of the tibia &gt; 10 mm in the sagittal plane; who are classified as candidates for primary total knee arthroplasty; who have some means of direct contact or through a close relative to facilitate communication; in the case of patients in the experimental group, who have availability for telerehabilitation sessions, access to communication via WhatsApp, and conditions for conducting supervised videoconferences	Patients will be excluded if they present unexpected adverse events that compromise the safety or continuity of the home-based physical exercise program; if they do not attend the scheduled telerehabilitation sessions; if they do not respond to communication attempts via WhatsApp; if they do not achieve the minimum score required on the Mini-Mental State Examination (MMSE) adjusted to their educational level with a score below the cutoff value indicating cognitive impairment which may compromise the proper understanding of the home-based exercise program as well as the use of WhatsApp for conducting and monitoring activities; if they have a cancellation or rescheduling of the surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-2n5fptq	Weight Training Exercises compared to Mouth and Throat Exercises as a treatment for Sleep Apnea	Terminated	Intervention	2025-02-27	<NULL>	<NULL>	7812	Resistance Physical Exercise compared to Oropharyngeal Exercises as a treatment for Obstructive Sleep Apnea Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-23	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-2n5fptq	<NULL>	Individuals of both sexes; aged 30 to 60 years; with symptoms of snoring and drowsiness related to Obstructive Sleep Apnea; who have the physical and cognitive conditions to participate in the intervention	Individuals with insufficient scores to characterize Obstructive Sleep Apnea; volunteers who already undergo another treatment for the disorder such as the positive pressure device used at night Continuous Positive Airway Pressure; oral devices; medication; previous nasal and jaw surgeries; those who do not agree to sign the Free and Informed Consent Form; those who are not present when the questionnaires are administered	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-4vjzbmd	Psychomotricity for children with Autism Spectrum Disorder	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7796	Psychomotor Intervention based on organization of Therapeutic Setting in cycles for children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-03	Universidade Evangélica de Goiás	Clinica de Neuroreabilitação Infantil Follow Kids	https://ensaiosclinicos.gov.br/rg/RBR-4vjzbmd	<NULL>	Volunteers with Autism Spectrum Disorder; levels of support I, II and III according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V); age between 3 and 10 years of age; children who demonstrate sufficient response to understand simple verbal commands; no medication changes at least six months before the start of the study and during its implementation	Volunteers who underwent surgery or neurolytic blockades in the 12 months prior to the study; orthopedic deformities; intellectual disorders that limited the performance of the intellectual activities proposed in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-4cj8njk	Effect of vitamin C use in third molar surgery	Recruitment completed	Intervention	2025-02-26	<NULL>	<NULL>	7797	Effect of vitamin C use on healing and postoperative symptomatology in mandibular third molar surgery	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2022-04-02	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4cj8njk	<NULL>	Healthy volunteers who do not continually use medications; both sexes; who are between 18 and 30 years old; that have teeth 38 and 48 in the same position; with indication for removal in an outpatient procedure under local anesthesia	Volunteers who do not agree to participate in the research after reading the Free and Informed Consent Form;  presence of pathological lesions such as cysts and/or tumors in the region surrounding or associated with the lower third molars; have any suspected or diagnosed allergy to any of the drugs used in the research; volunteers who did not return for the second surgical procedure, to be performed on the opposite side of the initial surgery; pregnant patients; volunteerswho have vitamin C deficiency and require regular vitamin supplementation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-8csbc2g	Personalized Nutrition in the care of people with Obesity: genetic risk and personalized guidance in controlling hunger and appetite	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7798	Precision Nutrition in the care of people with Obesity: (epi)genetic scores and personalized guidance in controlling appetite and satiety	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-8csbc2g	<NULL>	Men and women will be included; between 20 and 55 years old; overweight; high waist circumference; excess body fat associated with at least one of the other components of Metabolic Syndrome; obesity and excess body fat independent of the presence of the other components of Metabolic Syndrome	Pregnant women; lactating women; women in menopause; athletes; shift workers; people with physical and/or intellectual disabilities; intolerance or food allergies to the test foods; type 1 diabetes mellitus; autoimmune diseases or use of immunosuppressants; hormonal disease; digestive disease or alterations; carriers of inflammatory bowel or liver diseases; chronic kidney disease; pancreatitis; cardiovascular diseases; eating disorders; cancer; infectious episode in the last month; history of illicit drug use and/or alcohol consumption greater than 21 and greater than 14 units/week for men and women, respectively; having undergone bariatric surgery; indicating weight instability (5% of usual weight) in the last three months; habitual consumption of granola, nuts, whole grains or seeds (sesame, pumpkin and sunflowerseeds, flaxseed) &gt;30 g/day; following a vegan, vegetarian or dietary restriction diet (gluten, lactose); use of anti-inflammatory drugs, corticosteroids, antipsychotics, antidepressants that may affect appetite and energy metabolism; use of vitamin, mineral and omega-3 supplements; use of fiber supplements (psyllium, inulin); not having participated in nutritional interventions in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:13
RBR-5ystjk9	Aging Well: Nutrition, Food Education, and Quality of Life	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7799	Promoting healthy aging: Food and Nutrition Education and Quality of Life	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-10	Pontificia Universidade Católica de Campinas - PUC/ CAMPINAS	Pontificia Universidade Católica de Campinas - PUC/ CAMPINAS	https://ensaiosclinicos.gov.br/rg/RBR-5ystjk9	<NULL>	People aged 60 or over; male and female; independent; participants in the Vitalità program at the Pontifical Catholic University of Campinas	Older adults with self-reported cognitive diseases; Those who do not sign the Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:58
RBR-7dn5w43	Evaluation of the effects of Sedation with Midazolam and Nitrous Oxide versus Physical Restraint in children with Intellectual Disabilities during dental treatments	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7800	Randomized clinical trial of the effects of Sedation with Midazolam associated with Nitrous Oxide compared to Protective Stabilization during dental care for children with Intellectual Disabilities	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal do Rio de Janeiro	Faculdade de Odontologia da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7dn5w43	<NULL>	Children of both genders; with a physical status classification from I to III, as defined by the American Society of Anesthesiologists; aged between 3 and 12 years; prior diagnosis of intellectual disability confirmed by caregivers; behavior classified as negative or definitely negative on the Frankl scale during screening at the Clinic for Children with Disabilities of the Department of Pediatric Dentistry at the Faculty of Dentistry of the Federal University of Rio de Janeiro, indicating the need for protective stabilization to perform dental treatment; need for dental treatment identified during screening, including restoration, pulpal therapy, or simple extraction	Children weighing less than 15 kg; airway classification by the modified Mallampati scale equal to or greater than III; medical contraindication for intranasal medication sedation, inhalation sedation, or protective stabilization; presence of disabilities without intellectual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-2q5dg2d	Treatment of Dental Hypersensitivity with Low-power Laser and Resin Film: a clinical study	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7801	Photobiomodulation Therapy and Light-cured Resin Varnish as treatment for Cervical Dentin Hypersensitivity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-31	Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2q5dg2d	<NULL>	Volunteers of both genders; aged between 18 and 45 years; must present at least one premolar and at most eight premolars with cervical dentin hypersensitivity (CDH), with pain measured on the numerical rating scale (NRS) equal to or greater than 4 and with non-carious cervical lesion (NCCL) with a maximum depth of 1mm; volunteers with at least 20 teeth in occlusion	Volunteers with premolars with Cervical Dentin Hypersensitivity - CDH with active carious lesions; or with defective restorations; or with dental tissue loss requiring restorative treatment; or with pulp inflammation; or that serve as support for removable partial dentures or fixed prostheses; individuals undergoing ongoing orthodontic and periodontal treatment; those who report having received desensitizing treatment from a professional in the last six months or using desensitizing toothpaste in the last three months; those who have used anti-inflammatory drugs or analgesics at the time of recruitment; pregnant women or those who are breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-7w9ffgr	Efficacy of Alternative Braces to maintain space after Early Loss of Primary Molars: randomized clinical trial	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7802	Efficacy of Bonded Wire Space Maintainer for Early Loss of Primary Molars: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-15	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-7w9ffgr	<NULL>	Patients aged between 4 and 9 years; of both sexes; deciduous or mixed dentition stage; early loss of at least one primary molar; and presence of teeth adjacent to the edentulous space	Those who require space recovery; cases in which the permanent successor is in the eruption stage; enamel defects; as well as those who are not willing to participate or collaborate with the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-8gb3sfj	Effect of Rapid and Repeated Practice compared to Traditional Simulation on learning Cardiopulmonary Resuscitation by nursing students	Data analysis completed	Intervention	2025-02-26	<NULL>	<NULL>	7803	Effectiveness of simulation strategies in theoretical-practical learning about Cardiopulmonary Resuscitation for nursing students: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-14	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8gb3sfj	<NULL>	Being regularly enrolled in the first year of the Bachelor of Nursing course at the School of Nursing at the University of São Paulo (EEUSP); be available to participate in the three stages of the study, the first being distance learning and the others in person; be at least 18 years old; both sexes	Having physical limitations that would prevent participation in the simulated practical activity; having participated in a Basic Life Support (BLS) course within the past two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-2qdddys	The role of Physiotherapy in the management of post-cesarean Low Back Pain through Manual Therapy and Exercises	Recruitment completed	Intervention	2025-02-26	<NULL>	<NULL>	7804	Therapeutic approach for the management of post-cesarean Low Back Pain through Manual Therapy and Exercises	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade do Estado de Minas Gerais	Universidade do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2qdddys	<NULL>	From one year after the cesarean section; sedentary women; over 18 years of age; have consented to the Informed Consent Form; without cognitive deficits that hinder their understanding when performing the exercises, score 7 on the Roland Moris questionnaire; score greater than or equal to 3 on the visual analogue scale (VAS)	Failure to consent to the Informed Consent Form; less than one year since the cesarean section; performing some type of physical exercise; having already performed some procedure on the scar	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-10qjnp65	Protein Supplementation in the Functional Rehabilitation of critical patients	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7805	Protein Supplementation Strategies in the Functional Rehabilitation of critical patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade de Pernambuco	Hospital Universitário da Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-10qjnp65	<NULL>	Patients admitted to the Intensive Care Unit - ICU; over 18 years old; of both sexes; with indication of the use of exclusive enteral nutritional therapy; and that they undergo early motor rehabilitation according to the institution&apos;s protocol (24 hours after admission to the ICU, without intracranial hypertension, in hemodynamic and respiratory stability)	Patients under 18 years of age; who are on oral feeding; parenteral or mixed; or who have some type of contraindication to undergoing motor physiotherapy; patients with suspected or confirmed brain death; patients in palliative care; pregnant women; patients who have contraindications for using the cycle ergometer (skeletal, dermatological or surgical dysfunction); and Body Mass Index (BMI) greater than or equal to 30kg/m² (obesity)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-74snjc8	Brain Neuromodulation in children with Cerebral Palsy	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7806	Transcranial Stimulation by Photobiomodulation and Direct Electrical Current in children with Spastic Cerebral Palsy: a double blind, controlled, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Universidade Brasil	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-74snjc8	<NULL>	Diagnosis of spastic cerebral palsy; functional classification on Levels I, II,III or IV of the Gross Motor Function Classification System (GMFCS); ability to walk independently in at least the previous 12 months, even if requiring a gait-assistance device; age between four and 12 years; both genders; degree of understanding and cooperation compatible with the execution of the proposed activities; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-35r3zkc	Use of Silver Diamine Fluoride dental materials compared to Resin Sealant in the prevention of ooth Decay and Tooth Sensitivity in first permanent molars with the presence of Molar Incisor Hypomineralization: a randomized clinical trial	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7807	Use of Silver Diamine Fluoride compared to Resin Sealant in the prevention of Tooth Decay and Tooth Sensitivity in first permanent molars with MIH: a randomized clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-12-30	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Secretaria de Estado da Educação do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-35r3zkc	<NULL>	Children aged 6 to 10 years; both sexes; students from public schools in the city of Diamantina;who have at least one first permanent molar with Molar Incisor Hypomineralization (MIH) - MIH fully erupted with mild MIH; without cavitated dental caries, International System for Caries Detection and Assessment, (ICDAS 0 to 2); without restorations or sealants; children and their parents / guardians who agree to their child&apos;s participation in the study	Children who present systemic impairment that may alter their response to the proposed treatments, such as physical and neurological changes that impact oral hygiene; children who are allergic to any dental material to be used, as previously reported by their parents; children who refuse to undergo clinical examination and treatment; children who present post-eruptive cuspal rupture during the clinical examination; children who use orthodontic braces; children who present post-eruptive cuspal rupture during the clinical examination; children who use orthodontic braces	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-5dxr6cq	Effect of Muscle Strengthening by Distance Care: Randomized controlled trial	Recruitment completed	Intervention	2025-02-26	<NULL>	<NULL>	7808	Effect of Teleservice Strength Training. Randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-14	Universidade Federal de Alfenas - UNIFAL-MG	Universidade Federal de Alfenas - UNIFAL-MG	https://ensaiosclinicos.gov.br/rg/RBR-5dxr6cq	<NULL>	Participants with self-report of low back pain; of both sexes; aged between 18 and 30 years	Age less than 18 years and over 30 years and presenting a medical diagnosis of neurological; orthopedic; traumatological; rheumatological diseases that promote alterations in static balance or cause chronic pain; participants with uncontrolled arterial hypertension; skin lesions in the lumbar spine/lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-2mbkswx	Comparison of open surgery using sutures with video surgery using metal buttons in the surgical treatment of acute clavicle dislocation	Recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7810	Comparative analysis of open versus arthroscopic approaches in acute acromioclavicular injuries/dislocations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-20	Santa Casa Misericórdia Maceió	Fundação Educacional Jayme de Altavila - Fejal	https://ensaiosclinicos.gov.br/rg/RBR-2mbkswx	<NULL>	Patients of both sexes;over 18 years old; diagnosed with acute acromioclavicular dislocation within 21 days of injury; Rockwood type 3;4;5;6	Previous shoulder surgeries; multiple trauma patients; abuse of alcohol or illicit drugs; exposed injuries; carrier of neoplastic disease; associated fractures in the upper limb; adhesive capsulitis; glenohumeral osteoarthritis; psychiatric illness; pregnancy; comorbidities not clinically compensated; presence of active infection, loss of follow up of the first clinical evaluation carried out at 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-8kt9t54	The influence of practice with virtual video games on motor control and skill learning in young adults	Not yet recruiting	Intervention	2025-02-26	<NULL>	<NULL>	7811	The influence of Virtual Reality practice on motor control and skill learning in young adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal de São Carlos - UFSCar	Universidade de São Paulo - São Carlos/SP	https://ensaiosclinicos.gov.br/rg/RBR-8kt9t54	<NULL>	Be young adults; aged 18-30 years); with no prior experience with the games included in the practice protocol of the present study, either on Xbox 360º Kinect™ or on real practice	Body Mass Index corresponding to the obesity condition; present any visual, musculoskeletal, physical and/or neurological changes that could compromise the performance of the assessments and practice sessions proposed in this study; be absent from any of the assessments and/or practice sessions; have prior experience with the games included in the practice protocol, both virtual reality and real practice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-44cvfnq	Effects of a meditation and mindfulness program on the mental health of medical students	Data analysis completed	Intervention	2025-02-26	<NULL>	<NULL>	7836	Impact of a Mindfulness-Based Stress Reduction Program on medical students: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-29	Universidade do Grande Rio Professor José de Souza Herdy	Escola de Medicina e Cirurgia da Universidade Federal do Estado do Rio de Janeiro (UNIRIO)	https://ensaiosclinicos.gov.br/rg/RBR-44cvfnq	<NULL>	Medical students from Universidade do Grande Rio Professor José de Souza Herdy (UNIGRANRIO); both genders; own a smartphone with WhatsApp® and internet access; aged 18 years or older; provide written informed consent	Previous diagnosis of decompensated psychiatric disorders; inability to attend in-person sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-3v7cw2r	Development and testing of tools to facilitate oral hygiene for patients with Neuromotor Disability	Recruiting	Intervention	2025-02-25	<NULL>	<NULL>	7793	Creation and evaluation of tools to help with the oral hygiene of patients with neuromotor disability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-15	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3v7cw2r	<NULL>	Patients duly registered at the Clinic for Pediatric Patients with Disabilities of the Department of Pediatric Dentistry and Orthodontics of the Faculty of Dentistry - Federal University of Rio de Janeiro - FO/UFRJ; present cognitive deficit; limiting physical motor disability; do not perform their own oral hygiene, depending completely on a third party to perform this function;  have gingivitis and/or visible biofilm on the day of the clinical examination; age from 5 to 40 years; both sexes	Patients whose guardians/caregivers cannot participate in the interviews; in cases where it is completely unfeasible to manipulate this patient; patients with dental calculus that cannot be removed in an outpatient setting	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-108x4469	Vaginal birth or cesarean section: a conscious choice	Recruitment completed	Intervention	2025-02-25	<NULL>	<NULL>	7794	Strategies for changing attitudes towards elective cesarean in a public hospital	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-03	Faculdade de Medicina de Jundiaí	Faculdade de Medicina de Jundiaí	https://ensaiosclinicos.gov.br/rg/RBR-108x4469	<NULL>	Healthy pregnant women; in good overall health; who have opted for a cesarean section	Pregnant women with medical or obstetric indication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-9nmm7sz	Impact of telemedicine medical guidance on the continuation and satisfaction rates of the Etonogestrel releasing implant inserted after childbirth	Recruitment completed	Intervention	2025-02-25	<NULL>	<NULL>	7795	Impact of telemedicine medical guidance on the continuation and satisfaction rates of the Etonogestrel releasing implant inserted in the immediate postpartum period	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9nmm7sz	<NULL>	Postpartum women who have given birth at the Santa Isabel Maternity Hospital;  aged between 18 and 45 years; who express a desire to use the Etonogestrel implant after contraceptive instructions; who regularly have access to cell phones with the ability to receive video messages	Patients who do not have a mobile phone with access to the internet and the free WhatsApp messaging application; women with clinical conditions that hinder understanding of the video (addiction to the use of alcohol and/or illicit drugs, vision or hearing difficulties, psychiatric illnesses without adequate clinical treatment);  homeless women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-2t5r2xb	Efficacy of Electromyographic Biofeedback as an adjunctive therapy in the treatment of sequelae of eye closure during chewing in individuals with Peripheral Facial Paralysis: clinical trial	Recruiting	Intervention	2025-02-24	<NULL>	<NULL>	7785	Efficacy of Electromyographic Biofeedback as an adjunctive therapy in the treatment of Oro-ocular Synkinesis during chewing in individuals with Peripheral Facial Paralysis: a clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-15	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2t5r2xb	<NULL>	Availability to undergo all procedures outlined in the research; adult aged between 25 and 44 years; both sexes; diagnosed with acquired peripheral facial paralysis; classified as House-Brackmann III (with the presence of oro-ocular synkinesis during chewing); having a minimum of two years and a maximum of 10 years since the onset of the condition	History of surgical intervention and or use of botulinum toxin in the orbicularis oculi and or orbicularis oris muscles to treat facial paralysis sequelae; facial injuries that interfere with the placement of surface electrodes; skeletal dentofacial deformity identified through facial analysis; absence of more than one unreplaced tooth, verified through intraoral inspection; patients with a history of oncological and or neurological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-7nh566t	Effects of Omega-3 and Aspirin, with or without Antibiotics, in the treatment of Severe Gum Disease	Data analysis completed	Intervention	2025-02-24	<NULL>	<NULL>	7786	Clinical and microbiological effects of Immune modulation, with or without Systemic Antibiotics, in the treatment of Periodontitis	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-09-01	Universidade Guarulhos	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-7nh566t	<NULL>	Severe periodontitis; at least 15 teeth; aged over 29 years; males and females	Smokers; former smokers for at least 5 years; pregnant or lactating women; history of periodontal treatment in last 6 months; continuous use of oral antiseptics; use of systemic antibiotics, corticosteroids, non-steroidal anti-inflammatory drugs, immunosuppressants, estrogen, and estrogen receptor modulators; medicines that may influence bone metabolism, such as alendronate, calcitonin, and others, in the last 6 months; continuous use of medications; a systemic disease that may alter the response to periodontal or requiring prophylactic medication for dental treatment; report of allergy to metronidazole or amoxicillin, aspirin or fish and seafood; use of orthodontic appliances; prostheses; blood dyscrasias, gastritis or gastric ulcer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-10xprdbk	Omega-3 and Aspirin with Antibiotics to treat Gum Disease in people with Diabetes	Recruitment completed	Intervention	2025-02-24	<NULL>	<NULL>	7787	Omega-3 and Aspirin associated with Systemic Antibiotics in the periodontal treatment of patients with type 2 Diabetes Mellitus: local and systemic effects, immunological actions, and impact on oral and gut microbiota	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-06	Universidade Guarulhos	Universidade Guarulhos	https://ensaiosclinicos.gov.br/rg/RBR-10xprdbk	<NULL>	Stages III and IV Periodontitis; Grades B and C Periodontitis; type 2 Diabetes Mellitus; at least 15 teeth; 30 years and over; males and females	Smokers; pregnant women; lactating women; history of periodontal treatment in the last 6 months; continuous use of oral antiseptics, use of systemic antibiotics, corticosteroids, non-steroidal anti-inflammatory drugs, immunosuppressants, estrogen and estrogen receptor modulators, drugs that can influence the bone metabolism (Alendronate, Calcitonin and others) in the last 6 months; continuous use of medication; need for prophylactic medication for dental treatment (eg mitral valve prolapse); report of allergy to Metronidazole, Amoxicillin (as well as any other penicillin), Aspirin or fish/seafood; use of braces; extensive prosthetic rehabilitations; blood dyscrasias; gastritis or gastric ulcer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-5dt62k4	Serious game associated with Cycling for the treatment of Stroke patients	Data analysis completed	Intervention	2025-02-24	<NULL>	<NULL>	7788	Serious Game associated with Cycle Ergometry for rehabilitation of hemiparetic patients due to Stroke	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Faculdade Guilherme Guimbala	Faculdade Guilherme Guimbala	https://ensaiosclinicos.gov.br/rg/RBR-5dt62k4	<NULL>	Hemiparetic stroke patients volunteers; 18 years or older; clinically stable and in the chronic phase of the disease; able to walk independently, the use of a walking aid device was permitted; signing the Free and Informed Consent Form (FICF), expressing interest in participating in the project	Patients with hemiparesis resulting from pathologies other than stroke, as well as hemiplegic patients; patients who do not have lower limb impairment; patients who have bilateral motor impairment, which prevents characterization as hemiparetic; patients with severe visual and/or auditory impairment; uncooperative patients and/or with cognitive deficit (assessed with the Mini Mental State Examination); patients who are undergoing any other type of rehabilitation for the lower limbs or for the respiratory system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-8hhwzbj	The Effect of Physical Exercise on Long COVID	Data analysis completed	Intervention	2025-02-24	<NULL>	<NULL>	7790	Effect of Different Types of Physical Exercise on the Rehabilitation of Long COVID	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Instituto Federal de Educação, Ciência e Tecnologia de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8hhwzbj	<NULL>	Physically inactive for at least 3 months. aged 18 years or older. A positive COVID-19 test conducted at least 6 months ago. Both sexes	Younger than 18 years old. Active smoker. Never had COVID-19	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-6zhmt6r	Uterine removal with vaginal suspension using Splentis for women with uterine prolapse	Data analysis completed	Intervention	2025-02-24	<NULL>	<NULL>	7791	Evaluation of the efficacy and safety of Prophylactic Vaginal Dome Fixation using the Splentis™ device during Vaginal Hysterectomy in patients with Uterine Prolapse	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-06-01	Faculdade de Medicina do ABC	Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-6zhmt6r	<NULL>	Women at least 18 years old; with uterine prolapse grades III or IV; women wanting hysterectomy	History of thrombosis or thromboembolic disorders; chronic kidney or liver disease; cerebrovascular accident or transient ischemic attack; endometrial hyperplasia; rheumatological diseases; low- or high-grade squamous intraepithelial lesions of the cervix, vagina, or vulva; untreated genitourinary infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-7qc828r	Online brief Psychotherapy for Depression	Recruiting	Intervention	2025-02-24	<NULL>	<NULL>	7792	Brief Behavioral Activation for Depression adapted for teleheath of Brazilians	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-06	Instituto Brasiliense de Análise do Comportamento	Instituto Brasiliense de Análise do Comportamento	https://ensaiosclinicos.gov.br/rg/RBR-7qc828r	<NULL>	Ages between 18 and 60 years; both genders; meet the criteria for Major Depressive Disorder according to the DSM-5; have a score above 16 on the Hamilton Scale for Depression (GRID-HAM-D); literate Brazilians; use Whatsapp daily in their communications; schedule compatibility with research therapists; access to a computer, notebook, tablet or smartphone with a camera and internet connection; access to a confidential and suitable environment for carrying out teleservices; using antidepressants for at least two months or not using antidepressants for the same amount of time	Being in psychotherapeutic treatment; being diagnosed with bipolar disorder; being diagnosed with psychotic disorders; being diagnosed with current abuse/dependence on psychoactive substances; being at high risk of suicide (according to the diagnostic interview)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-6cmsgwx	Website in auditory rehabilitation of the elderly	Recruiting	Intervention	2025-02-21	<NULL>	<NULL>	7775	Digital interface in auditory rehabilitation of the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-16	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-6cmsgwx	<NULL>	Group A1 and A2: Be regularly enrolled in the Speech Therapy Clinic of FOB/USP; be 60 years of age or older, regardless of gender, and are therefore considered elderly, according to the principles of the World Health Organization (WHO, 2002); have normal cognitive function assessed using the CS-10 protocol; have undergone audiological evaluation and have symmetrical bilateral sensorineural hearing loss, mild to moderate or moderately severe according to the quadritonal average of audiometric thresholds at frequencies of 500 Hz, 1000 Hz, 2000 Hz and 4000 Hz; The ears will be considered symmetrical when they present the same degree and configuration of audiometric curve, with a difference of up to 15 dB between the ears; have an indication for using hearing aids for the first time; have mobile devices; know how to use mobile devices or have relatives/caregivers who can assist them; Group B1 and B2: Communication Partners must be 18 years of age or older, regardless of gender, must live with the elderly and be available to accompany them during all face-to-face consultations; have mobile devices; know how to use mobile devices	Group A1 and A2: Having undergone ear surgery; having deformities or other changes in the external ear; having cognitive, neurological, motor impairments and/or serious health problems; Group B1 and B2: Not participating in presentials consultations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-6bn7y6z	Evaluation of Colchicine Peeling for the treatment of premalignant skin lesions	Data analysis completed	Intervention	2025-02-21	<NULL>	<NULL>	7776	Colchicine peeling versus placebo for actinic keratoses	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-08-16	Sociedade Brasileira de Dermatologia Regional São Paulo - FUNADERSP	Sociedade Brasileira de Dermatologia Regional São Paulo - FUNADERSP	https://ensaiosclinicos.gov.br/rg/RBR-6bn7y6z	<NULL>	Sign the Free and Informed Consent Form; Age over 18 years of age for both sexes; Present at least three and no more than ten lesions clinically compatible with actinic keratosis on each forearm, bilaterally	Less than three or more than ten lesions on each forearm; Use of any specific treatment for AKs and/or cutaneous cancerization in the last 6 months; Selected treatment area with an atypical clinical appearance or other extensive dermatoses on the forearms; Current and previous clinical diagnosis or evidence of any medical comorbidity that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; Present hypersensitivity or allergy to any of the substances under study; Patients using any systemic or topical immunosuppressive substance, oral retinoid, in addition to other local treatments (e.g. corticosteroids, anti-inflammatories, retinoids); Immunocompromised individuals; Coagulation disorders; Suspected or confirmed pregnancy; Women who are breastfeeding; Refusal to undergo dermatological ultrasound	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-9g67ytj	Effects of Functional Exercise applied Online or in Person on pain and function in patients with Fibromyalgia	Recruiting	Intervention	2025-02-21	<NULL>	<NULL>	7777	Effects of Functional Exercise via Telerehabilitation vs. In-person training on pain and functionality in patients with Fibromyalgia: a pragmatic clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9g67ytj	<NULL>	Patients diagnosed with fibromyalgia; of both sexe; aged between 18 and 60 years old; who are physically independent will be included in the study	Patients who have musculoskeletal and cardiovascular disorders that prevent them from performing physical tests and training configurations; with a diagnosis of other diseases that interfere with modulation of pain levels; who have undergone surgical procedures, physical exercise and/or physiotherapy treatment in a systematic manner in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-3kwr4tz	Study on Mortality, Infections, and Surgeries in the Treatment of Hydrocephalus Caused by Infratentorial Tumors in Children and Adolescents	Recruiting	Observational	2025-02-21	<NULL>	<NULL>	7778	Observational, prospective, and multicenter study to assess Mortality, Infection Rates, and number of surgeries related to the treatment of Hydrocephalus Secondary to Infratentorial Tumors in childhood and adolescence	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-01	Escola Paulista de Medicina	Instituto de Oncologia Pediátrica - IOP/GRAACC	https://ensaiosclinicos.gov.br/rg/RBR-3kwr4tz	<NULL>	Patients of both sexes; under 18 years old; with a diagnosis of hydrocephalus secondary to a primary central nervous system tumor; located in the posterior fossa, characterized by clinical findings and radiological imaging (CT scan or MRI); Hydrocephalus secondary to a posterior fossa tumor will be characterized when the patient presents a tumor in the posterior fossa, causing obstruction of cerebrospinal fluid circulation; enlargement of the lateral ventricles and third ventricle, with this enlargement documented through imaging exams such as cranial CT or MRI; identification, in addition to the ventricular enlargement, of an increase in the temporal horns of the lateral ventricles (&gt;2mm); and transependymal edema in the frontal and/or occipital horns of the lateral ventricles; Additionally, the patient must present signs and symptoms related to increased intracranial pressure, such as: headache; irritability; vomiting; strabismus and/or paresis of the 6th cranial nerve unilaterally or bilaterally; papilledema; bradycardia; hypertension; and altered level of consciousness (drowsiness, stupor, or coma); Participating centers will be those that offer, both through the public health system and/or the private healthcare system, surgical treatment for patients under 18 years old with posterior fossa tumors; Patients who have initially been treated for hydrocephalus at an external center may also be included, provided that all necessary information for study inclusion is available	Patients over 18 years old; patients with lesions in other sites that do not focus primarily on the posterior fossa; patients who have previously undergone surgical resection of posterior fossa tumors; patients without hydrocephalus associated with a posterior fossa tumor; patients with posterior fossa tumors and hydrocephalus but who will not undergo surgical resection of the lesion (for example, diffuse midline pontine gliomas); or cases considered only for biopsy of the lesion; patients who refuse to participate in the study; and patients whose data regarding hydrocephalus and its characterization cannot be retrieved with the necessary details for the study will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-7n3y2gq	Application of light to treat wounds in the feet of people with Diabetes	Recruiting	Intervention	2025-02-21	<NULL>	<NULL>	7781	Study to test the application of red and blue light in the treatment of wounds in the feet of people with Diabetes	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2023-11-25	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7n3y2gq	<NULL>	Patients over 18 years old; of both sexes; already undergoing treatment for type 1 or type 2 diabetes mellitus; with a clinical diagnosis of peripheral neuropathy in the feet; having one or more active ulcers for at least 1 month; and with an ulcer of at least 1 cm² in area	Patients with end-stage chronic kidney disease/hemodialysis, heart failure grades III and IV; or other associated causes of skin ulcers (leprosy, lymphedema/elephantiasis, chronic venous insufficiency, hereditary hemoglobinopathies, squamous cell carcinoma, invasive mycoses, mycobacterioses)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-3g8vv3k	Effects on posture and movement after Non-Invasive Neuromodulation in Spinal Cord Injury	Recruiting	Intervention	2025-02-21	<NULL>	<NULL>	7782	Galvanic Vestibular Stimulation in Spinal Cord Injury: effects on motor control	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Universidade Municipal de São Caetano do Sul	Universidade Municipal de São Caetano do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3g8vv3k	<NULL>	Having sensorimotor sequelae such as tetraparesis/tetraplegia or paraparesis/paraplegia secondary to spinal cord trauma; being over 18 years old; both sexes; being under medical supervision for their condition; and following the prescribed medical guidelines	Having any non-compensated clinical alteration; having a pressure ulcer; having a metal implant in the skull; having episodes of seizure; having a pacemaker or other type of neuromodulator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-38qpwdp	Evaluation of the use of Laser applied to the Face for the Prevention os Salivary Gland Dysfunctions in patients after Radioiodine Therapy	Recruitment completed	Intervention	2025-02-21	<NULL>	<NULL>	7783	Evaluation of Extraoral Photobiomodulation in the Prevention of Salivary Gland Dysfunctions by Radioiodine Therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Fundação Antônio Prudente- A.C.Camargo Cancer Center	Fundação Antônio Prudente- A.C.Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-38qpwdp	<NULL>	Volunteers must be 18 years of age or older; with differentiated thyroid cancer; both sexes; indication of radioiodine therapy after total thyroidectomy surgery	Patients who have received any previous radioiodine therapy or radiotherapy in the head and neck region; patients who underwent thyroidectomy at another institution; previous diseases of the salivary glands; clinical conditions or impaired general health that prevent them from participating in the study; patients who are using bethanechol chloride or any other cholinergic drugs; patients who do not attend at least 4 sessions of photobiomodulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-6k6344n	Evaluation of toothpastes to treat Tooth Sensitivity in patients undergoing Home Whitening teeth treatment	Not yet recruiting	Intervention	2025-02-20	<NULL>	<NULL>	7770	Evaluation of desensitizing toothfrices with obliterating and neural action in reducing Tooth Sensitivity during Home Whitening with Hydrogen Peroxide	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-05	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6k6344n	<NULL>	Patients with initial color selection equal to or below A2, B2 or C2; patient with periodontal health condition; patient aged 18 to 50 years; patients of both sexes; patient with central, lateral and canine incisors present in the mouth	Patient who did not sign the free and informed consent form;  patients with initial color selection equal to or above A1, B1 or C1; patient with active periodontal disease; patient with a history of sensitivity; patient with direct and/or indirect anterior restorations involving the buccal surface; patients with fixed prostheses on more than 2 anterior teeth; patients who already use continuous desensitizing toothpaste; patients who have already had whitening in the last 5 years; patients with chronic use of anti-inflammatory or analgesic medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-54x2zpz	Effects of facilitated restraint on cerebral oxygen consumption during the suction of secretions present in the nostrils and throat of preterm newborns	Recruiting	Intervention	2025-02-20	<NULL>	<NULL>	7771	Acute effects of aspiration in preterm newborn with or without facilitated contention on cerebral oxygen consumption: a randomized crossover clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2024-12-01	Faculdade de Medicina da Universidade de São Paulo	Hospital Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-54x2zpz	<NULL>	Newborns under 35 weeks admitted to the Neonatal Intensive Care Unit; both genders; monitored with brain near-infrared light spectroscopy	Congenital Heart Disease; diaphragmatic hernia; fracture of upper limbs or lower limbs; use of sedation or analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-78bn3gf	Effect of Strength Training and Miconia Albicans on Pain, Inflammation and Functionality in women with knee Osteoarthritis	Not yet recruiting	Intervention	2025-02-20	<NULL>	<NULL>	7772	Effect of Resistance Training and Miconia Albicans on Pain, Inflammation and Functionality in women with knee Osteoarthritis: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-78bn3gf	<NULL>	Female subjects with radiographs showing knee osteoarthritis grades II and III on the Kellgren and Lawrence osteoarthritis classification. Knee pain greater than 3 on the numerical pain rating scale. Age 50 to 70 years and functional impairment in the past 3 months that met at least one of the American College of Rheumatology classification criteria	Female individuals with neurological, cardiovascular and/or pulmonary diseases that may compromise the execution of the exercise protocol. Have used intra-articular injections of steroids or other substances in the last three months. Have systemic inflammatory disease. Have had orthopedic surgery on the lower limbs or are unable to perform the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-28pnbq3	The effect of breast milk extraction on blood sugar control in children at risk	Recruiting	Intervention	2025-02-20	<NULL>	<NULL>	7773	Impact of breast milk expression on glycemic control of infants at risk for neonatal hypoglycemia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-01-20	Escola Paulista de Enfermagem	Escola Paulista de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-28pnbq3	<NULL>	"Brazilian women; age 18 years; in singleton pregnancies; who express the desire to breastfeed,
newborns with risk factors for hypoglycemia; women who gave birth within 3 hours"	Children with congenital malformations and/or associated pathologies; premature babies (bigger 37 weeks of gestation) and those who were referred to the Neonatal Intensive Care Unit or Intermediate Care shortly after birth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-4ngc9n5	Pilot study of a clinical trial comparing patients with a type of brain tumor who will undergo radiotherapy and chemotherapy treatment with those who will undergo this treatment combined with the use of the medication Perillyl Alcohol by inhalation	Recruiting	Intervention	2025-02-20	<NULL>	<NULL>	7774	Pilot study of a randomized clinical trial comparing patients with Glioblastoma undergoing standard treatment (radiotherapy and chemotherapy) versus standard treatment combined with the use of Intranasal Perillyl Alcohol	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2024-11-04	Hospital de Clínicas da Unicamp	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4ngc9n5	<NULL>	Adult individuals; of both genders and transgenders; aged 18 and over; diagnosed with Glioblastoma; who underwent a surgical procedure with partial removal of the tumor evidenced by brain MRI; who will be starting standard treatment with radiotherapy and chemotherapy and have a KPS ≥ 60	Patients allergic to lemon; who have the presence of another primary tumor or proven metastasis; who have a concomitant life-threatening disease or a pathology that affects blood circulation and the coagulation system; pregnant women or those intending to become pregnant and those who do not accept to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-63q9z47	Clinical evaluation of restorations located close to the gums using universal adhesives	Not yet recruiting	Intervention	2025-02-19	<NULL>	<NULL>	7765	Interaction of universal dentin bonding systems of non carious cervical lesions: a randomized clinical controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Clinica Multidisciplinar	https://ensaiosclinicos.gov.br/rg/RBR-63q9z47	<NULL>	Patients of any gender; at least 18 years old; good general health; acceptable oral hygiene; presence of at least 20 teeth in occlusion; two or more teeth (in occlusion, vital and without mobility) with similar cervical lesions predominantly caused by Erosive Tooth Wear and with a supragingival margin	Caries activity; systemic health complications; active or chronic periodontal disease; severe bruxism or other parafunctional habits; patients using a complete denture or implants occluding with the teeth of interest; patients who have undergone orthodontic, hypersensitivity or whitening treatment in the last 6 months; pregnant or breastfeeding women; allergies to the main components of the products used in this study; unavailability of time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-26x4qtw	Effects of peripheral ischemia on clinical recovery in patients with stroke	Not yet recruiting	Intervention	2025-02-19	<NULL>	<NULL>	7766	Effects of ischemic post-conditioning on clinical recovery in patients with stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Hospital Universitário da Universidade Estadual de Ponta Grossa	Grupo de Estudo sobre Respostas e Adaptações Fisiológicas ao Exercício da Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-26x4qtw	<NULL>	Both-gender patients; diagnosed with Ischemic Stroke with infarction of large arteries or small arteries; aged between 45 and 65 years; with clinical stability; independence prior to the event; degree of acute Ischemic Stroke at the time of hospital admission between 5 and 20 on the National Institutes of Health Stroke Scale will be included	Patients with infarctions of cardioembolic origin; patients whose investigation does not define the site of infarction; with previous Stroke; with systolic blood pressure above 200 mmHg; with ulcerative lesions in the lower limbs; patients who, after thrombolytic therapy, present lower than 5 points on the National Institutes of Health Stroke Scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-4473f2y	The performance of crowns compared to restorations that use posts inside the tooth root	Recruiting	Intervention	2025-02-19	<NULL>	<NULL>	7767	Clinical performance of endocrowns compared to restorations using intraradicular retainers: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-30	Universidade Federal de Pelotas - Faculdade de Odontologia	Universidade Federal de Pelotas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-4473f2y	<NULL>	Good general health conditions, endodontically treated molars, minimum supragingival margin of 2 mm, element that will receive treatment must be in occlusion, that have at least one adjacent element, that has at least 20 teeth in the mouth	Dental pain, unsatisfactory endodontic treatment or signs of periapical lesions at the time of radiographic or clinical examination, root fracture, need to behave as a prosthetic abutment, mobility greater than grade I, participants using orthodontic braces	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-888vpty	Effect of Manual Therapy in singers with Reflux	Terminated	Intervention	2025-02-19	<NULL>	<NULL>	7768	Effect of Osteopathic Manual Treatment on Reflux symptoms in singers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Escuela de Osteopatia de Madrid Brasil	Escuela de Osteopatia de Madrid Brasil	https://ensaiosclinicos.gov.br/rg/RBR-888vpty	<NULL>	Singing individuals of both sexes will be admitted; with the diagnosis of reflux using the Reflux Symptom Index (RSI) questionnaire; be aged between 21 and 50 years; being an amateur singer complaining of reflux; being using or not taking medication for reflux; agree to the Free and Informed Consent Term (ICF)	The person who is an instrumentalist will be excluded; having trunk and/or head and/or neck surgery; having received osteopathic care in the last 3 months until the beginning of this research; being in speech therapy; use orthodontic appliance; have a diagnosis of hiatal hernia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-3qr2cht	The effect of different Toothpastes in Peri-Implat Mucositis	Recruiting	Intervention	2025-02-19	<NULL>	<NULL>	7769	The effectiveness of Toothpastes with different Active Principles in Peri-Implat Mucositis: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-3qr2cht	<NULL>	Male and female participants; aged 18 or over; presence of at least one dental implant supporting single or multiple prostheses, with at least 1 year in function; diagnosis of peri-implant mucositis: presence of at least two sites with bleeding after probing; availability to participate for the 6 months of the study; have all upper and/or lower anterior incisors	Medical history that includes serious medical conditions or communicable diseases such as, but not limited to: human immunodeficiency virus (HIV), diabetes outside of glycemic target, rheumatic fever and bone diseases. Presence of untreated periodontitis and/or dental caries. Presence of peri-implantitis: presence of bleeding on probing and/or suppuration, probing depths greater than or equal to 6mm and level bone greater than or equal to 3mm. Motor or cognitive difficulties detected at the time of supervised hygiene. Use of antibiotics in the last month prior to the study. History of allergy to therapeutic ingredients (Chlorhexidine and Fluorides). Alcoholics and Smokers. Pregnant and breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-99b93yh	Color match of fluid restoration placed close to the gums before and after in-office whitening	Recruiting	Intervention	2025-02-18	<NULL>	<NULL>	7761	Color matching of unichromatic flowable composite resin before and after in-office bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-99b93yh	<NULL>	Men and women; Good general health; good oral hygiene; present at least 20 teeth under occlusion; at least two non-carious cervical lesions comparable in size; shape and dimensions; non-retentive; deeper than half a mm; and involve both the enamel and dentin of vital teeth; the cavosurface margin cannot involve more than 50% of the enamel; never having undergone dental whitening	Higiene oral extremamente pobre; usando dispositivos ortodônticos; periodontite severa ou crônica; hábitos de bruxismo pesado; alergia conhecida a materiais à base de resinas ou qualquer outro material usado neste estudo; mulheres grávidas ou lactantes; uso crônico de drogas anti-inflamatórias; analgésicas e psicotrópicas; paciente que já realizou clareamento dental	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-35q38yx	Effects of cardiovacular and metabolic rehabilitation during dialysis with or without respiratory muscles training.	Recruiting	Intervention	2025-02-18	<NULL>	<NULL>	7763	Effects of a conventional versus adapted intradialytic cardiovascular and metabolic rehabilitation program with inspiratory muscles training: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande no Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-35q38yx	<NULL>	Subjects over eighteen years of age will be included with no maximum age limit; both genders; diagnosed with stage five Chronic Kidney Disease for at least three months; undergoing hemodialysis at the Santa Rita Nephrology Center at least twice a week	Those who have some degree of neurological impairment will be excluded; who already undergo physiotherapeutic treatment; do not have the ability to walk independently; that they are bedridden; who are unable to carry out the evaluative tests and physiotherapeutic procedures proposed in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-6ffgn7t	Efficacy of Zinc Acetate mouthwash in controlling Bad Breath - A clinical study	Not yet recruiting	Intervention	2025-02-18	<NULL>	<NULL>	7764	Efficacy of Zinc Acetate mouthwash in controlling Halitosis - Randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-13	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-6ffgn7t	<NULL>	Participants of both sexes; aged over 18 years; students in the health area of ​​the Federal University of Piauí, Teresina, Brazil, diagnosed with halitosis by the organoleptic method at levels 2, 3, 4 or 5 on the Schmidt scale; who have at least 15 teeth in the mouth and do not use removable dentures	Individuals with a history of allergic reactions to the components of the tested solution; who have used mouthwash of any type in the last two days before the exam; who have consumed alcoholic beverages in the last 24 hours before the exam and who are conventional or electronic smokers will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-7mpnx6t	Assessment of heart health and metabolism in Menopausal women using Isoflavones: a control group study	Not yet recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7751	Cardiovascular evaluation and metabolic profile of women in Menopause using Daidzein and Genistein: a placebo-controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-03	Fundacao Universidade de Pernambuco	Fundacao Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7mpnx6t	<NULL>	60 female volunteers; age between 49 and 52 years old; in menopause after one year of the last menstrual period	Patients with cardiorespiratory disorders; neurological; and other known impairments that prevent the subject from carrying out the procedures; do not drink alcoholic beverages; nor consume substances containing isoflavones such as green tea, peas, peanuts, chickpeas, lima beans, broad beans, lentils and flaxseeds; or carry out high-intensity training for 24 hours prior to the assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-92v86nn	Effect of CBD and THC substances present in the cannabis plant as maintenance therapy for parkinson&apos;s disease	Recruitment completed	Intervention	2025-02-17	<NULL>	<NULL>	7753	Effect of THC and CBD cannabinoids combined as maintenance therapy for parkinson&apos;s disease: an open-label exploratory clinical trial (cpf study)	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2024-01-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-92v86nn	<NULL>	Having completed the double-blind phase of the study without interruptions; having not presented serious adverse effects in the double-blind phase; signing the informed consent form; age 50 or older; male or female	Medical decision that participation in the study is not in the best interest of the patient; presence of any condition that does not allow the protocol to be followed safely, such as serious adverse effects	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-47274gx	Effect of strength training combined with physiotherapeutic exercises on muscle recovery and rehabilitation in athletes and active adults: an evaluation of the heart, muscle, and blood: a randomized placebo-controlled trial	Not yet recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7754	Effect of strength training combined with different therapeutic modalities on musculoskeletal mecovery and rehabilitation in athletes and recreationally active adults: an integrated approach to cardiovascular, autonomic, neuromuscular, and blood responses: a randomized placebo-controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Sociedade Unificada Augusto Motta	Sociedade Unificada Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-47274gx	<NULL>	Perform at least 300 minutes of physical activity per week. Be between 18 and 59 years old. Both sexes. Be free from functional limitations that prevent the tests and/or the proposed protocol from being performed.	Consuming caffeine-based ergogenic aids. Reporting any type of acute dizziness. Presenting abnormal fluid accumulation (edema), especially in the lower limbs. Presenting impairments in the basilar artery that make cervical manipulations impossible. Diagnoses that affect postural control, such as vestibular dysfunction, Alzheimer&apos;s disease, Parkinson&apos;s disease, or motor neuron disorders. History of lower limb trauma in the last year. Presence of severe cardiopulmonary disease. Participants currently involved in a structured exercise program focused on postural control.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-7kwv2ct	Intense functional training for adults at cardiac risk: is it safe and does it benefit the heart?	Recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7755	High intensity functional training in adults with cardiovascular risk factors: feasibility, safety and cardiovascular health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-03	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-7kwv2ct	<NULL>	Adults of both sexes; aged between 18 and 59 years; inactive for at least 3 months; with medical clearance	Participation in less than 70% of the interventions; no medical clearance; no participation in data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-67fdcbg	Effects of Neurostimulation in children with speech and language difficulties	Not yet recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7756	Transcranial Direct Current Stimulation in cognitive and language skills	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal de Sergipe	Programa de Pós-graduação em ciências aplicadas à Saúde (PPGCAS)	https://ensaiosclinicos.gov.br/rg/RBR-67fdcbg	<NULL>	Children of any sex; have a diagnosis of speech and language disorders; aged between 6 and 12 years old; inserted in the regular school environment; have degrees of understanding and collaboration compatible with carrying out the proposed intervention, that is, accept the placement of electrodes and the time required for stimulation	Children whose guardians, at some point during the research, withdraw their free and informed consent; children with epilepsy; who use metallic brain implants or hearing aids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-6sff9qt	Postoperative nausea and vomiting in Brazil	Not yet recruiting	Observational	2025-02-17	<NULL>	<NULL>	7757	Survey on the use of antiemetics for the prophylaxis of postoperative nausea and vomiting in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-05-28	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-6sff9qt	<NULL>	Anesthesiologists and physicians specializing in Anesthesiology of the Brazilian Society of Anesthesiology. Who are duly registered and actively enrolled in the company. That they are in accordance with the Informed Consent Form and the research instruments. Both sexes	Anesthetists not registered on the Brazilian Society of Anesthesia website	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-27sysfx	Effect of local application of Chalcone T4 associated with conventional treatment of Periodontitis: Randomized clinical study	Recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7758	Effect of local application of Chalcone T4 in the adjunctive treatment of Periodontitis: Randomized clinical study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-07-01	Faculdade de Odontologia da Universidade Estadual Paulista Julio de Mesquita Filho Campus Araraquara	Centro Universitário Central Paulista	https://ensaiosclinicos.gov.br/rg/RBR-27sysfx	<NULL>	Healthy volunteers; both genders; over 18 years old; non-smokers; with the presence of stage III grade A periodontitis, in at least two sites in two different quadrants; with a probing depth greater than or equal to five millimeters; active periodontal disease, verified by the presence of bleeding on probing; have at least fifteen remaining teeth	Volunteers with systemic diseases that contraindicate periodontal treatment, which require antibiotic prophylaxis or use of medications that interfere with the evolution of periodontal disease and/or the results of treatment; pregnant or lactating women; volunteers who smoke or who stopped the habit less than 5 years ago; having used antimicrobials in the last three months; having used steroid or non-steroidal anti-inflammatory medications continuously for more than 7 days in the last 3 months; having received periodontal treatment in the last year; have fewer than 15 teeth present	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-10prjzs4	Perceived age assessment in women undergoing Facial Lifting	Recruiting	Intervention	2025-02-17	<NULL>	<NULL>	7759	Perceived age assessment in women undergoing Rhytidoplasty with Deep Plane, High SMAS, and Plication techniques: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10prjzs4	<NULL>	Female patients; aged between 45 and 60 years; voluntary attendance at the Plastic Surgery Clinic at Universidade Federal de São Paulo – Escola Paulista de Medicina; complaints of rhytidosis and facial laxity	Patients who have undergone facial surgeries, implants, malar fillers, or chemical or physical peels in the past 12 months; diagnosis of uncontrolled acute or chronic diseases such as diabetes mellitus, systemic arterial hypertension, healing disorders, autoimmune diseases, collagen diseases, infectious diseases, and psychiatric disorders; smokers; use of anticoagulants, antiplatelet agents, or corticosteroids; history of hypersensitivity to anesthetics; illiteracy; abandonment of clinical follow-up at any stage of the research or voluntary withdrawal from participation during the study; undergoing any other aesthetic facial procedure during the 6-month follow-up, such as Botox injections, facial fillers with hyaluronic acid, chemical peels, microneedling, fractional lasers, non-surgical facelifts, radiofrequency treatments, and CO2 resurfacing procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-7m82zcf	DAMA: Device for assessing the walking of people Post-Stroke	Recruiting	Observational	2025-02-17	<NULL>	<NULL>	7760	DAMA:  Portable device for kinematic Assessment of Gait in Post-Stroke individuals	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal do Rio Grande do Norte	Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7m82zcf	<NULL>	For individuals without a stroke - individuals who do not have any neurological, orthopedic or rheumatological condition that affects walking; of both genders; aged between 20 and 70 years. For individuals with stroke - have a diagnosis of stroke; of any etiology; at any stage of this condition (acute, subacute or chronic); be able to walk independently indoors - Functional Ambulation Category - FAC scores equal to or greater than 3; who do not use a walking aid; who do not have unstable heart conditions - New York Heart Association (NYHA) scores equal to or greater than 3; who do not have a clinical condition other than stroke that affects walking; of either gender; aged between 20 and 70 years old	Participants who for any reason feel unable to complete the evaluation protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-3gc2sqb	Effects of a mindfulness-based intervention on nurse leaders&apos; emotional intelligence, self-compassion and resilience	Not yet recruiting	Intervention	2025-02-14	<NULL>	<NULL>	7747	Effects of a mindfulness-based intervention on nurse leaders&apos; emotional intelligence, self-compassion and resilience: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-28	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3gc2sqb	<NULL>	Volunteer nurse leaders, hired by the São Paulo Hospital and Outpatient Clinics, Prof. Dr. Waldemar de Carvalho Pinto General Hospital of Guarulhos, State Hospital of Diadema Governador Orestes Quercia, General Hospital of Pedreira, and Municipal Hospital of Barueri Dr. Francisco Moran, São Paulo, Brazil; be 18 years of age or older; both sexes	Be a daily practitioner of any type of practice that uses mindfulness (such as: Yoga, Tai Chi Chuan, Chi Kung, among others), as indicated by the Sociodemographic and Clinical Questionnaire (QSDC); participants with a diagnosis and/or treatment for psychosis or schizophrenia, as indicated by the QSDC; participants who present suicidal ideation or severe depression, as scored by the Patient Health Questionnaire-9 (PHQ-9), 20 points or more for cutoff; participants who have problems with alcohol and drug abuse, as verified by the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) questionnaire, 26 points or more for cutoff	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-9d29wpj	Effect of yerba mate extract consumption on anthropometric parameters, body composition, and blood markers of inflammation, glycemic profile, and lipid profile in overweight individuals	Not yet recruiting	Intervention	2025-02-14	<NULL>	<NULL>	7748	Yerba mate extract (Ilex paraguarensis): effect of ingestion on anthropometric parameters, body composition, inflammatory markers, glycemic profile, and lipid profile in overweight individuals: a randomized, placebo-controlled, crossover, and triple-blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-10	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-9d29wpj	<NULL>	Individuals over the age of 18; Body Mass Index (BMI) greater than or equal to 24.99 kg/m²; both sexes	Individuals with a Body Mass Index (BMI) greater than or equal to 24.99 kg/m²; significant weight variation (more than 10%) in the last 3 months; use of anti-inflammatory medications; pregnancy or breastfeeding; allergies or hypersensitivity to any of the ingredients of the interventions; smoking; alcoholism; intense physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-7bb6mhc	Effect of Vaginal Laser in menopause: a comparative study on Genitourinary Symptoms	Data analysis completed	Intervention	2025-02-14	<NULL>	<NULL>	7750	Genitourinary Syndrome of menopause in patients treated with Vaginal CO2 Laser: a randomized clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7bb6mhc	<NULL>	Healthy postmenopausal women (at least 12 months since their last menstrual period, or with bilateral oophorectomy, or hysterectomized with follicle-stimulating hormone higher than 40 U/L; estradiol lower than 25 pg/mL); negative oncotic colpocytology within the last year; who agree to participate in the study and sign the informed consent form (ICF)	Active or recent (&lt;15 days) vaginal lesions; use of hormone replacement therapy in the last 6 months; untreated genitourinary tract infections; abnormal uterine bleeding; history of photosensitivity disorder or use of photosensitizing drugs; grade II-III genital prolapse (according to the Pelvic Organ Prolapse Quantification system, POP-Q); bacterial or viral vaginal infection (HPV, Herpes); immunosuppression; chronic corticosteroid use; scleroderma; extensive prior radiotherapy; burns in the area; collagen disorders; pregnancy and breastfeeding; genital neoplasia; anticoagulant therapy; patients with sling/mesh; uncontrolled diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-275z28y	In-office Bleaching with low vs. high concentrate: a randomized clinical Ttrial	Recruiting	Intervention	2025-02-13	<NULL>	<NULL>	7744	In-office Bleaching with low vs. high concentrate Hydrogen Peroxide: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-25	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-275z28y	<NULL>	Volunteers aged at least 18 years, with good general and oral health, teeth free of carious lesions, gingival recessions or periodontal disease in the anterior region, who agree to the informed consent form (ICF) and who have at least one of their canines in A2 color or darker, according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany) will be included in the study.	Volunteers who have previously undergone a whitening procedure, who report previous tooth sensitivity, who have dentures, fixed orthodontic appliances, restorations on the front teeth, endodontic treatment on the front teeth, teeth stained by tetracycline or fluorosis or who have visible cracks will be excluded from the study. In addition, patients who continuously use analgesic or anti-inflammatory medications, pregnant or lactating patients, and those with bruxism habits will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-29mvy54	Clinical study on the effect of Microfocused Ultrasound on facial rejuvenation	Not yet recruiting	Intervention	2025-02-13	<NULL>	<NULL>	7745	Clinical study on the efficacy and safety of Microfocused Ultrasound for Facial Rejuvenation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-02	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-29mvy54	<NULL>	Patients aged between 35 and 65 years; patients who show moderate signs of skin aging; both sexes	Patients with a history of photosensitivity will be excluded; tendency to form keloids; with dermatitis; active herpes infection at the procedure site; pregnant women; breastfeeding women; pacemaker holders; with decompensated chronic diseases; wearing metal prostheses in the area to be treated; with a history of heart disease; patients with a history of autoimmune diseases using isotretinoin; anticoagulants; with a history of previous aesthetic treatments in the area	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3xtpk68	Study on the effects of Acupuncture on endometrial characteristics in embryo transfer preparation cycles	Not yet recruiting	Intervention	2025-02-13	<NULL>	<NULL>	7746	Effect of Acupuncture on Endometrial Characteristics in Cycles and Preparation for Embryo Transfer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3xtpk68	<NULL>	Women of childbearing age; between 18 and 44 years old, and that the collection of their eggs must be carried out until the age of 41; who have already undergone in vitro fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI) and have had implantation failure; who have frozen embryos and wish to transfer them; who agree to participate in the research after reading and signing the informed consent form	Daily use of medications (anti-inflammatories and muscle relaxants); women undergoing treatments for psychiatric illnesses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3x4fk7v	How breathing techniques help remove secretions in patients on mechanical ventilation: a clinical study	Recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7734	Effect of Expiratory Chest Compression maneuver and Mechanical Hyperinflation on secretion removal in mechanically ventilated patients: a crossover clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade do Oeste de Santa Catarina	Universidade do Oeste de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-3x4fk7v	<NULL>	Patients over 18 years of age; both sexes; under mechanical ventilation for more than 24 hours; with criteria for airway aspiration and Free and Informed Consent signed by family members or guardians	Patients with mucus hypersecretion; need for aspiration less than 2 hours old; monitored cranial hypertension greater than 20cmH2O; haemodynamic instability; Richmond Agitation Sedation score greater than 0; untreated pneumothorax; pulmonary haemorrhage; immediate post-operative neurosurgery; acute respiratory distress syndrome; end-expiratory pressure setting greater than 10cmH2O and severe bronchospasm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-29x9zbc	Effects of bandaging on pain and abdominal muscle separation in postpartum women: a randomized controlled trial	Not yet recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7735	Effects of Kinesio Taping on pain and diastasis of the rectus abdominis muscles in postpartum women: a randomized controlled trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-17	Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-29x9zbc	<NULL>	Postpartum women; normal-risk pregnancy; single fetus; age between 18 and 40 years; up to 72 hours postpartum; via vaginal delivery or cesarean section; full-term birth between 37 and 42 weeks; no abdominal surgeries in the last 12 months	Obstetric complications; postpartum hemorrhage; postpartum depression; infections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-858ss8v	Cellular functional response of the musculoskeletal system of hip replacement surgery patients	Recruitment completed	Observational	2025-02-12	<NULL>	<NULL>	7736	Proliferative and functional response of the musculoskeletal system of hip Arthroplasty patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-01	Instituto Nacional de Traumatologia e Ortopedia	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-858ss8v	<NULL>	Over 18 years; hip arthroplasty eligible; both sexes	Neoplasm; positive viral diagnosis by serology or antigen (Hepatitis B, C and HIV); indication for revision hip arthroplasty surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-9t6j4j5	How Auriculotherapy can help children overcome Fear and Anxiety at the dentist	Recruitment completed	Intervention	2025-02-12	<NULL>	<NULL>	7737	Auriculotherapy in the treatment of fear and anxiety in children facing dental care - Evaluation using the Ryodoraku method	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-10	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9t6j4j5	<NULL>	Children; both genders; age between 6 and 12 years old; fear and anxiety regarding dental treatment	Systemic changes and special needs; children without a legal guardian; inability to attend the 5 sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3q7szpv	Effects of Teleconsultation for the care of children with feeding difficulties	Not yet recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7738	Effects of a Teleconsultation program on the quality of care for parents and caregivers of children with Dysphagia: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-05-15	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3q7szpv	<NULL>	Third, a non-progressive neurogenic disorder medical diagnosis, and a neurogenic dysphagia clinical diagnosis; Ser pacientes attended no ambulatório Gastropedriatria do Hospital das Clínicas da Universidade Federal de Pernambuco; Fazer parte dos casos identificados no ano de 2024 no respectiveo serviço; Aceitar participar da teleconsulta e do estudo.	First consultation; Do not accept consultation via video call.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-10t8m6m2	High versus low dose Vitamin D3 in severe Systemic Lupus Erythematosus on Pulse Methylprednisolone: a randomized, double blind, placebo controlled clinical trial	Data analysis completed	Intervention	2025-02-12	<NULL>	<NULL>	7739	Assessment of Vitamin D supplementation in patients with Systemic Lupus Erythematosus admitted to the rheumatology ward	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-05-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10t8m6m2	<NULL>	Patients with Systemic Lupus Erythematosus (according to the classification criteria defined by the Systemic Lupus International Collaborating Clinics of 2012). Age greater than or equal to 18 years. High disease activity (SLEDAI-2K greater than 11) requiring hospitalization for administration of intravenous pulse therapy with methylprednisolone. Patients with Systemic Lupus Erythematosus and concomitant infection were also eligible, provided they presented active disease after clinical evaluation. Both sexes	Concomitant diagnosis of another autoimmune disease; Body Mass Index - BMI greater than or equal to 35 kg/m2; severe renal failure - estimated glomerular filtration rate below 30 ml/min; history of nephrolithiasis, hypercalciuria (greater than or equal to 4 mg/kg/24 hours); hypercalcemia (total calcium corrected by albumin greater than 10.2 mg/dl); intestinal malabsorption; chronic liver disease; pregnancy, lactation; refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-4pp65c6	Effects of a bodybuilding protocol with a minimum training dose in 8 weeks on the symptoms of Premenstrual Syndrome and the coping strategies of university students	Recruitment completed	Intervention	2025-02-12	<NULL>	<NULL>	7740	Effects of an 8-week minimal dose protocol on psychocogical symptoms of Premenstrual Syndrome (PMS) and the coping strategies of college students	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-21	Universidade Federal do Pará	Programa de Pós Graduação em Ciências do Movimento Humano	https://ensaiosclinicos.gov.br/rg/RBR-4pp65c6	<NULL>	Be woman; university student enrolled in a higher education institution; be between 18 and 50 years of age; have regular menstrual cycles; not be pregnant; not making use of medication for psychological control; does not have pathologies in the reproductive system; does not have musculoskeletal diseases; being sedentary; Premenstrual Syndrome carrier	Do not completely fill out any of the questionnaires given before and during the protocol; absence from training sessions; present pregnancy during the protocol; stop answering the questionnaire, practice other exercises during the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-95p3jgp	Effect of Vagus Nerve Electrostimulation on Heart Rate Variability	Recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7741	Effect of different frequencies and laterality of Transcutaneous Vagus Nerve Stimulation on Heart Rate Variability: a randomized crossover study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-08	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-95p3jgp	<NULL>	Healthy volunteers; both genders; non-smokers; aged between 18 and 40 years; able to read and write Brazilian Portuguese sufficiently to complete the data collection instruments	Volunteers who smoke; history of alcohol or drug abuse; diagnoses of heart disease, hypertension, suspected or confirmed pregnancy, cognitive changes that make it impossible to collaborate in the intervention and data collection, injuries to the auricle or absence of the auricle	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-22bjcq6	Comparison of Mat Pilates versus Equipment-based Pilates for treating knee Osteoarthritis	Not yet recruiting	Intervention	2025-02-12	<NULL>	<NULL>	7743	Comparison between Mat Pilates and Equipment Pilates in the Treatment of Patients with Knee Osteoarthritis: A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-20	Departamento de Fisioterapia da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-22bjcq6	<NULL>	Individuals of both sexes. Aged between 50 and 80 years. Presence of chronic-degenerative joint impairment in the knee for more than 12 weeks. Sedentary individuals diagnosed with unilateral or bilateral knee osteoarthritis. Confirmed diagnosis of knee osteoarthritis according to the criteria of the American College of Rheumatology presence of knee pain and at least one of the following criteria age equal to or greater than 50 years, crepitus during knee movements, increased sensitivity to compression, reduced local warmth, bone enlargement, and morning stiffness lasting less than 30 minutes. Grade 2 or higher osteoarthritis according to the Kellgren and Lawrence classification. Presence of pain with a score equal to or greater than 3 on the Numeric Pain Scale. Use of the Physical Activity Readiness Questionnaire to assess the need for medical evaluation before physical activity practice	Asymptomatic knee osteoarthritis. History of previous surgery on the lower limbs. Diagnosis of neurological inflammatory rheumatic infectious or traumatic disorders. Severe visual impairments. Use of prosthetics in the lower limbs. Inability to understand Portuguese. Body Mass Index above 40. Physical therapy treatment performed in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-6fxhwqw	Evaluation of the use of membranes obtained from blood centrifugation for gingival retraction repair surgeries in smoker patients	Data analysis completed	Intervention	2025-02-11	<NULL>	<NULL>	7732	Evaluation of the use of Platelet Rich Fibrin for root coverage of Cairo Type I gingival recession in smoker patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-09	UNIOESTE - Universidade Estadual do Oeste do Paraná	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-6fxhwqw	<NULL>	Smoking patients; with Cairo Type I gingival recession; bilateral; aged between 20 and 50 years; both genders; without comorbidities seeking treatment at the Unioeste Dentistry Clinic	Exclusion criteria include; individuals who do not meet the criteria of cigarette consumption &gt; 10 cigarettes/day; positive history of antibiotic therapy in the last six months and anti-inflammatories; steroids or non-steroids; in the three months preceding the study; positive history of pregnancy; positive history of any systemic problem that contraindicates the surgical procedure; endodontic treatment or pulp pathology in the involved tooth; pathogenic occlusal interferences and previous surgery at the site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-7x8bkv2	Evaluation of how Cryotherapy aids athlete recovery after intense CrossFit workouts	Not yet recruiting	Intervention	2025-02-11	<NULL>	<NULL>	7733	Evaluation of the effects of Cryotherapy on the recovery of delayed onset Muscle Soreness in athletes after high-intensity interval training in WOD Murphy in CrossFit: a controlled, randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7x8bkv2	<NULL>	Participants must be between 18 and 45 years old. Of either sex. They must have at least six months of regular CrossFit experience, training a minimum of three times per week. It is essential that athletes are considered healthy and do not have any current or chronic musculoskeletal injuries that could interfere with the execution of the Murph WOD or the application of cryotherapy. Participants must not have performed the Murph WOD or similar high-intensity exercises in the four weeks prior to the start of the study. All participants must provide written informed consent, indicating that they understand the study procedures, risks, and benefits. Additionally, they must be available for training sessions, cryotherapy application, and subsequent assessments within the timeframe established by the study. Athletes&apos; body mass index (BMI) must be between 18.5 and 30 kg/m². Participants must not have used cryotherapy regularly as a recovery method in the three months preceding the study. It is important that athletes demonstrate the ability to follow study instructions and protocols consistently and correctly. Participants must be able to read and comprehend the language in which the study and informed consent are presented, ensuring they fully understand all instructions and study requirements	Participants who present any medical condition that may be exacerbated by intense exercise or exposure to cold, such as severe cardiovascular, respiratory, or metabolic diseases, will be excluded. Athletes with a history of chronic or recent musculoskeletal injuries that may interfere with the execution of the Murph WOD or the application of cryotherapy will also be excluded. Individuals who have performed the Murph WOD or similar high-intensity exercises in the four weeks prior to the start of the study will not be eligible. Participants who have regularly used cryotherapy as a recovery method in the three months preceding the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-93bscrv	Effects of Mechanical Stimulation using different Sialogogues on the evaluation of Salivary Flow in adults	Recruiting	Intervention	2025-02-11	<NULL>	<NULL>	7819	Effects of Mechanical Stimulation using different Sialogogues on the assessment of Salivary Flow in adults	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-26	Faculdade de Ciências de Saúde da Universidade de Brasília	Hospital Universitário de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-93bscrv	<NULL>	For Group 1, participants must be over 18 years old, of both sexes, in good systemic health, and without comorbidities such as hypertension, diabetes mellitus, or immunosuppressive diseases. They must be non-smokers, and alcohol consumption should be socially moderate. Additionally, alcohol consumption is not allowed within 24 hours prior to the collection. For Group 2, participants must be over 18 years old and exhibit symptoms of xerostomia	For Group 1, individuals who are using medications known to negatively affect salivary flow or induce xerostomia, including antihistamines, antidepressants, and anxiolytics, will be excluded. Smokers and heavy drinkers will also be excluded, as well as participants who consumed alcohol within 24 hours before the sialometry session. For Group 2, participants who do not present symptoms of xerostomia will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-99z7jnq	Effect of Ketamine combined with conventional treatment in Treatment-Resistant Depression and Suicide Risk	Not yet recruiting	Intervention	2025-02-10	<NULL>	<NULL>	7730	Effectiveness of Ketamine as an adjuvant to Lithium Carbonate and standard pharmacological treatment in adults with treatment-resistant unipolar and bipolar depression and the risk of suicide with intent: a double-blind study	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2025-02-15	Hospital Universitário Walter Cantídio Universidade Federal do Ceará	Hospital Universitário Walter Cantídio Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-99z7jnq	<NULL>	Participants of either sex; aged between eighteen and sixty-five years; body weight of fifty kilograms to one hundred twenty kilograms; informed consent obtained prior to participation; effective contraceptive methods for sexually active heterosexual women of childbearing potential (blood or urine test requested during screening, on medication administration days, and in case of clinical doubt about pregnancy status during the observation period); clinical stability demonstrated by physical examination, medical history, vital signs, and twelve-lead electrocardiogram during screening; abnormalities allowed if deemed clinically insignificant by the principal investigator and documented in source records; agreement to receive standard pharmacological treatment for treatment-resistant depression, treatment-resistant bipolar depression, and/or suicidal risk, as assessed by the responsible physicians; treatment-resistant depression: current major depressive episode without psychotic features, confirmed by the Structured Clinical Interview for DSM-5 Disorders Clinical Trials Version, Montgomery-Åsberg Depression Rating Scale score of eighteen or higher, resistance to two or more antidepressants and/or adjunctive agents; treatment-resistant bipolar depression: current major depressive episode without psychotic features, confirmed by the Structured Clinical Interview for DSM-5 Disorders Clinical Trials Version, diagnosis of bipolar disorder type I or II according to DSM-5 criteria, absence of sustained symptomatic remission for at least eight weeks or intolerance to two different treatments; suicidal risk with Montgomery-Åsberg Depression Rating Scale score of twenty-eight or higher, current suicidal ideation with intention confirmed by the Columbia-Suicide Severity Rating Scale and Montgomery-Åsberg Depression Rating Scale item 10 score ≥ 4	Manic episode limited to groups with treatment-resistant depression or suicidal intent; major depressive episode with psychotic features; schizophrenia or schizoaffective disorder as determined by the Structured Clinical Interview for DSM-5 Disorders Clinical Trials Version; alcohol or substance use disorder, excluding tobacco, or withdrawal symptoms requiring detoxification; inpatient or outpatient detoxification treatment within six months prior to screening; suicidal ideation or behavior primarily due to a condition other than major depressive disorder; current clinical diagnosis of autism spectrum disorder, neurocognitive disorders, or intellectual disability; history of seizures, except for childhood febrile seizures; malnutrition; inability to provide informed consent or comply with study requirements; pregnancy, lactation, or intention to become pregnant within the next twelve weeks; active infection with hepatitis B virus, hepatitis C virus, human immunodeficiency virus, or COVID-19; history of traumatic brain injury within the last six months; history of hypersensitivity to the study medications or their excipients; use of monoamine oxidase inhibitors within fourteen days before screening; cardiac disease or abnormal cardiac repolarization, including a history of myocardial infarction, angina pectoris, or coronary artery revascularization within six months prior to the start of the study treatment; history of clinically significant cardiac arrhythmias, complete left bundle branch block, advanced atrioventricular block, including bifascicular block, Mobitz type two, or third-degree atrioventricular block within six months prior to the start of the study treatment; Fridericia-corrected QT interval (electrocardiographic trace measured from the beginning of the QRS complex to the end of the T wave) at rest of greater than or equal to four hundred fifty milliseconds for men or greater than or equal to four hundred sixty milliseconds for women at screening or prior to the first dose on day one; inability to determine the Fridericia-corrected QT interval (electrocardiographic trace measured from the beginning of the QRS complex to the end of the T wave); risk factors for Torsades de Pointes, including uncorrected hypokalemia or hypomagnesemia, history of heart failure, or history of clinically significant or symptomatic bradycardia, long QT syndrome, family history of sudden unexplained death or congenital long QT syndrome; concomitant medication with a known risk of Torsades de Pointes that cannot be discontinued or replaced with a safe alternative medication seven days before screening and throughout the double-blind phase; average systolic blood pressure greater than one hundred forty millimeters of mercury or diastolic blood pressure greater than ninety millimeters of mercury at screening and before the first dose of medication on day one; elevated blood pressure or intracranial pressure that poses a serious risk, including vascular disease such as aneurysm and a history of intracerebral hemorrhage; any other condition, including liver disease or malignancy, that, according to the principal investigator&apos;s assessment, compromises the participant&apos;s safety; evidence of significant renal impairment indicated by an estimated glomerular filtration rate of less than forty milliliters per minute per one point seventy-three square meters at screening; use of other investigational medications within thirty days before screening; women of childbearing potential unless using highly effective contraceptive methods during the study treatment and for one week after discontinuation of the medication; effective contraceptive methods include total abstinence when consistent with the participant&apos;s preferred and usual lifestyle; bilateral oophorectomy with or without hysterectomy, total hysterectomy, or tubal ligation at least six weeks before administration of the investigational medication; male sterilization at least six months before screening; use of intrauterine device or intrauterine system; oral contraceptive or systemic hormonal contraception, including transdermal or implanted hormonal methods; women considered postmenopausal and not fertile if they have experienced twelve months of natural amenorrhea with a clinically appropriate profile, history of age-appropriate vasomotor symptoms, bilateral oophorectomy with or without hysterectomy, total hysterectomy, or tubal ligation for at least six weeks; absence of previous clinical exams or assessments that may confirm the absence of the aforementioned conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-996f8qn	Effects of Galvanic Vestibular Stimulation on posture and movement in patients with Parkinson&apos;s Disease: randomized clinical trial	Recruiting	Intervention	2025-02-10	<NULL>	<NULL>	7731	Effects of Galvanic Vestibular Stimulation on motor control in patients with Parkinson&apos;s Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-26	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-996f8qn	<NULL>	Patients between 50 and 75 years of age; female or male; with a diagnosis of Parkinson&apos;s Disease - idiopathic PD in stages 2-3 of the modified Hoehn &amp; Yahr Disability Scale (HY); undergoing regular monitoring at the Movement Disorder Outpatient Clinic; able to walk independently	Unable to remain independently in the standing position; severe visual impairment or not compensated with the use of corrective lenses; orthopedic disorders resulting in limitation of movement; using medication that acts on the vestibular system (e.g.: cinnarizine, flunarizine, betahistine, dimenhydrinate, meclizine and gingko biloba, among others); have Deep Brain Stimulation (DBS); history of seizures, pacemaker or metal implants in the head and neck region; undergoing neurofunctional physiotherapy and not accepting to suspend this treatment during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-485qvzm	Using light therapy to help treat Sickle Cell Anemia	Not yet recruiting	Intervention	2025-02-08	<NULL>	<NULL>	7726	Photobiomodulation Terapy: a novel approach to support the treatment of Sickle Cell Anemia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-485qvzm	<NULL>	Have a diagnosis of sickle cell anemia; be 12 years old; both sexes; the weight of these individuals must be equal to or greater than 40 kg; must be treated at the Hospital Foundation of Hematology and Hemotherapy of Amazonas	Individuals with a diagnosis of coagulation factor disorders; frequent and recent hemorrhagic episodes; glaucoma; pregnancy; the presence of malignant tumors or benign tumors with the potential to become malignant; active sepsis; chest trauma; history of tracheostomy; autoimmune disease; conditions of light sensitivity or use of photosensitive drugs; neurodegenerative diseases, and terminal illnesses will not be admitted to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-557kt34	Effects of Functional Training on Cardiopulmonary  Capacity, Muscle Strength, Mobility, Balance and Quality of Life in patients with Chronic Obstructive Pulmonary Disease	Terminated	Intervention	2025-02-08	<NULL>	<NULL>	7727	Effects of Functional Training on Cardiopulmonary Capacity, Muscle Strength and Endurance, Mobility and Balance of patients with Chronic Obstructive Pulmonary Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-04-04	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-557kt34	<NULL>	Patients aged 40 years or older, both gender; with clinical and functional diagnosis of Chronic Obstructive Pulmonary Disease regardless of time and degree of obstruction; able to walk without the use of gait aids	Patients with a self-reported history of unstable angina and/or acute myocardial infarction for less than three months; neurological and musculoskeletal diseases that prevented the performance of the tests and the functional training protocol;  patients whose obstruction was not confirmed through the pulmonary function test; inability to perform or complete the proposed tests or not complete the entire functional training protocol; absence for more than two sessions (consecutive or not)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3z4dd72	Raising children and dreams: randomized clinical trial in a tertiary hospital	Recruiting	Intervention	2025-02-08	<NULL>	<NULL>	7728	Raising children and dreams	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-22	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3z4dd72	<NULL>	Pregnant teenager; aged 14 to 19 years old; who is in the second trimester between 14 and 28 weeks of gestation; and who undergoes prenatal care at Centro de Atenção Integral à Saúde da Mulher e do Recém-nascido - CAISM/UNICAMP	Pregnant teenager who has difficulty reading, writing and understanding questionnaires; pregnant teenager who does not have access to and availability of the internet or cell phone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-95qrz8g	Evaluation of the use of Triplenex in Glaucoma: clinical trial	Recruitment completed	Intervention	2025-02-06	<NULL>	<NULL>	7720	Evaluation of the use of Triplenex (triple fixed combination) in patients with Glaucoma: randomized clinical trial	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-95qrz8g	<NULL>	Patients over 18 years old; both genders; diagnosed with glaucoma (determined by at least 2 criteria: intraocular pressure without eye drops above 21mmHg; typical defect in perimetry; localized damage in the nerve fiber layer); using at least 3 different classes of hypotensive eye drops; informed consent form granted	Patients with a history of ocular surface disease; intraocular surgeries (except cataract surgery); ocular trauma;  secondary glaucomas; current use of contact lenses; systemic medications that may alter the tear film;  steroids; or intolerance to any of the study drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-6bw8bwv	Increased dose of medication for stem cell collection in Multiple Myeloma patients undergoing Bone Marrow Transplantation	Recruiting	Intervention	2025-02-06	<NULL>	<NULL>	7721	Preemptive increase in granulocyte colony-stimulating factor on the fourth day of mobilization for autologous hematopoietic stem cell transplantation in Multiple Myeloma based on CD34+ cell count	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-06-12	Universidade Federal de Juiz de Fora UFJF	Hospital Universitário da Universidade Federal de Juiz de Fora da Empresa Brasileira de Serviços Hospitalares (HU-UFJF/Ebserh)	https://ensaiosclinicos.gov.br/rg/RBR-6bw8bwv	<NULL>	Patients diagnosed with multiple myeloma; patients who will undergo autologous hematopoietic stem cell transplantation; CD34+ count &lt; 10 cells on the fourth day of mobilization; be 18 years old or older; be male or famale; be carrying out mobilization only with G-CSF; be carrying out the first mobilization	Patients undergoing chemomobilization; patients undergoing mobilization with G-CSF and plerixafor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-722dg2y	Evaluation of the treatment of Uterine Endometriosis with three types of hormones: Dienogest pill, Etonogestrel implant and System releasing Levonorgestrel	Not yet recruiting	Intervention	2025-02-06	<NULL>	<NULL>	7722	Evaluation of the treatment of Adenomyosis with Dienogest, Etonogestrel Implant and Intrauterine System releasing Levonorgestrel – randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2026-02-01	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-722dg2y	<NULL>	Women; age between 18 and 45 years old; diagnosis of adenomyosis, both by magnetic resonance imaging and transvaginal ultrasound; have agreed to participate in the study and signed the Free and informed consent form	Women with uterine fibroids, endometrial polyps and other structural causes of abnormal uterine bleeding; women with cardiovascular, hepatic, renal failure or any other contraindications for the use of progestogens or the intrauterine system; women not having initiated sexual activity; women who cannot read or have some cognitive deficit that prevents them from understanding the questionnaires and the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-5w5x86y	Use of feedback device in cardiac arrest simulations by nurses	Recruitment completed	Intervention	2025-02-06	<NULL>	<NULL>	7723	Analysis of the use of feedback devices in simulated cardiac arrest care by nurses	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-10-03	Hospital Universitário da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5w5x86y	<NULL>	Active healthcare nurses; aged 18 years or older; of both sexes; from critical and non-critical adult patient units; working across all three shifts (morning, afternoon, and night)	Working in administrative areas of the hospital; being an instructor of Basic or Advanced Life Support courses; having completed another Basic or Advanced Life Support course between the first and second stages of the study; having health issues that impair CPR skills performance or being pregnant at the time of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-6b8jvpk	Effects of manual gripping exercise with a stress ball on blood pressure and heart rate variability in hypertensive elderly women	Recruiting	Intervention	2025-02-06	<NULL>	<NULL>	7724	Effects of isometric handgrip exercise performed with a ball antistress in the cardiovascular responses of elderly hypertensive women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Educação da Universidade Federal da Bahia - FACED	Faculdade de Educação da Universidade Federal da Bahia - FACED	https://ensaiosclinicos.gov.br/rg/RBR-6b8jvpk	<NULL>	being female; being aged 60 years or older; having been diagnosed with hypertension through a medical report or self-reporting as having hypertension and being on a prescribed antihypertensive medication; having been on antihypertensive medication at a maintained dose for the last 6 months; not having secondary hypertension and/or target organ damage; not using medications that directly affect cardiac autonomic regulation (e.g., beta-blockers and non-dihydropyridine calcium channel blockers, antidepressants); not having other cardiovascular diseases, aside from hypertension; not having grade II obesity or higher; not having diabetes with complications or using insulin; not having orthopedic conditions that prevent the practice of isometric resistance training; not being a smoker or having smoked in the last year; not undergoing hormone therapy	present safety blood pressure (BP) above 160 mmHg for systolic blood pressure (SBP) and/or 100 mmHg for dyastolic blood pressure (DBP) on the day carrying out the exercise in two consecutive reschedulings;  impossibility to continue a collection for health reasons or any other reason raised by the participant; decide leave the study voluntarily; impossibility of carrying out experimental sessions intervention and control with a time interval of less than 3 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-9xdn99g	Clinical evaluation of restoration for dental restoration near the gum before and after in-office bleaching	Recruiting	Intervention	2025-02-06	<NULL>	<NULL>	7876	Color matching of unichromatic composite resin before and after in-office bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9xdn99g	<NULL>	Good general health; good oral hygiene; present at least 20 teeth under occlusion; at least two non-carious cervical lesions comparable in size, shape and dimensions; non-retentive; deeper than half a millimeter; involve both the enamel and dentin of vital teeth; the cavosurface margin cannot involve more than 50% of the enamel; never having undergone dental whitening	Extremely poor oral hygiene; wearing orthodontic appliances; severe or chronic periodontitis; heavy bruxism habits; known allergy to resin-based materials or any other material used in this study; pregnant or lactating women; chronic use of anti-inflammatory, analgesic and psychotropic drugs; patients who have already undergone dental whitening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-4f7w4b6	Assessment of the female intimate area before and after the use of treated and untreated pantyliners	Recruitment completed	Intervention	2025-02-06	<NULL>	<NULL>	8233	Single-center, parallel, single blind clinical study to evaluate the urogenital microbiota and skin condition before and after wearing treated pantyliners with prebiotic and untreated control pantyliner	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-09	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	https://ensaiosclinicos.gov.br/rg/RBR-4f7w4b6	<NULL>	Females; 18 to 45 years old; in good general health, with regular monthly menstrual cycles who are not expected to menstruate during the study; participants with healthy and intact skin in the test areas; and be willing to comply with study requirements	Participants who are pregnant or intending to become pregnant during the study; history of chronic or currently active gynecological pathologies or urogenital infections in the last 3 months; used systemic and/or topical antibiotics, antifungals, and/or corticosteroids within 4 weeks prior to visit 1 and throughout the study; any other medical condition or history that may compromise the study results or the subject’s safety.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-7s58x6v	Effect of Myofascial Release on Post-Exercise Recovery in Water Polo Athletes	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7706	Effect of Release of Trigger Points on Functional Capacity, Biomechanical and Physiological Variables in Recovery After Game Simulation in Water Polo Athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Centro Universitário do Sagrado Coração - UNISAGRADO	Centro Universitário do Sagrado Coração - UNISAGRADO	https://ensaiosclinicos.gov.br/rg/RBR-7s58x6v	<NULL>	(a) male athletes; (b) age 16 to 25 years old; (c) have at least one year of experience in the sport; (d) perform a training load of at least 10 hours per week in the sport; (e) participate in at least regional level competitions	(a) have no reports of muscle injury in the thigh in the three months prior to the study, (b) joint injuries in the hip, such as femoroacetabular impingement or tendinopathies of the tendons of the hip muscles or trochanteric, iliopectineal or ischial bursitis diagnosed by a clinician; (c) do not present a drop in performance for more than four weeks that could characterize the occurrence of non-functional overreaching or signs of overtraining syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-5rf37wv	The Effect of a Protein Restricted Diet on Markers of Renal Function in Patients with Long-Term Renal Impairment Who are Undergoing Conservative Treatment	Not yet recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7707	Effect of Low-Protein Diet on Renal Function Markers in Conservatively Treated Patients with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-05	Hospital Universitário Lauro Wanderley da Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5rf37wv	<NULL>	Adult patients 18 years of age and older treated at the Nephrology Outpatient Clinic of the Lauro Wanderley University Hospital; Chronic Kidney Disease stage 3B to 5 not on dialysis; Glomerular filtration rate between 14-60 mL/minute; Male and female	Patients with chronic kidney disease due to autoimmune disease; Transplant recipients; Polycystic kidney disease; Renal neoplasia or single kidney disease; Liver Disease; Human Immunodeficiency Virus Carriers; Smokers; Pregnant women; Patients using dietary supplements such as probiotics, prebiotics, symbiotics, and antioxidants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-4cfz6sp	Clinical Evaluation of Composite Resins Tetric N-PowerFill 2 vs. Tetric NCeram 2 in Deciduous Molars: A Clinical Study	Not yet recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7708	Clinical Evaluation of Tetric N-PowerFill 2 vs. Tetric N-Ceram 2 in primary posterior teeth: A prospective, randomized, double-blinded parallel study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4cfz6sp	<NULL>	Good general and oral health; no need for endodontic or periodontal treatment; patients between three and ten years old who require a restoration in a primary posterior tooth; any gender	Severe systemic diseases; poor oral hygiene; allergy to any components present in the materials used; patients with a high risk of pulp exposure; endodontic complications; chronic use of medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-9cdr2yx	Telerehabilitation on patients undergoing Surgical Treatment for Breast Cancer	Data analysis completed	Intervention	2025-02-05	<NULL>	<NULL>	7709	Analysis of the influence of Telerehabilitation on the Functional Capacity and Pulmonary Function of patients undergoing Surgical Treatment for Breast Cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-9cdr2yx	<NULL>	women over 18; breast cancer diagnosis; Internet access; undergoing surgical treatment for breast cancer; agree to participate in the research	women with some myoskeletal, orthopedic, neurological dysfunction; cognitive and/or communication impairment; volunteers who refuse to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-3w64rhx	Clinical study to explore the efficacy of a diaper changing products regimen in diaper rash prevention	Recruitment completed	Intervention	2025-02-05	<NULL>	<NULL>	7710	Pilot, comparative, monocentric clinical study to explore the efficacy of a diaper change regimen, composed by diaper, diaper rash cream and wet wipes, on diaper rash prevention (E005562C)	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-14	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	https://ensaiosclinicos.gov.br/rg/RBR-3w64rhx	<NULL>	Infants from 6 to 12 months old; both sexes; in good general health; free from diaper rash or presenting a mild to moderate diaper rash; legal guardians are more than 18 years old and have signed the informed consent form	Subjects who present any allergy and sensitivity to products of the same category of the investigational products; present any history and skin condition that may compromise the study results or the subject’s safety; and have used oral and/or topical antibiotics, antifungals, antihistamines and/or corticosteroids in the 2 weeks prior to enrollment visit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-3tbxz4g	Pilates for low back pain in individuals with Parkinson’s disease	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7713	Pilates for non-specific chronic low back pain in individuals with Parkinson’s disease: protocol for a type 1 hybrid effectiveness-implementation randomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de Minas Gerais	Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3tbxz4g	<NULL>	Clinical diagnosis according to the criteria of the United Kingdom Parkinson’s Disease Society Brain Bank; non specific low back pain lasting for more than three months; pain intensity of at least three points on Numerical Pain Rating Scale, able to read and understand Portuguese; stable use of antiparkinsonian medication; preserved cognitive function; ability to walk independently; both sexes; no age restrictions	Diagnosis of other neurological and psychiatric diseases; history of trauma; nerve root compression; fracture; cancer; infection; or spinal surgery; participation in Pilates or physiotherapy sessions for treating low back pain within the last three months; visual or hearing impairments; any contraindication to exercise; post operative complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-8tsjf97	Effectiveness of Muscle Training and Respiratory Incentives in People Who Have Undergone Cardiac Surgery	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7714	Effectiveness Of incentive Spirometry in a Hospital-based Cardiac Rehabilitation program for patients undergoing Cardiac Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal de Santa Maria	Instituto de Cardiologia do Rio Grande do Sul - Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-8tsjf97	<NULL>	Age over 40 years; preoperative valve replacement; preoperative myocardial revascularization; both sexes	Previous diagnosis of infectious disease; severe uncorrected valvulopathy; severe lesion of the left main coronary artery; congestive heart failure; unstable angina; peripheral neuropathy; nephropathy; severe musculoskeletal disease; morbid obesity; cancer patients undergoing chemotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-4wrk7dy	Clinical evaluation of a universal material to cover tooth wear close to the gum before and after in-office whitening	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7716	Universal composite resin color compatibility before and after in-office whitening	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4wrk7dy	<NULL>	Minimum age of 18 years; both genders; good oral hygiene; present at least 20 teeth under occlusion; at least two non-carious cervical lesions comparable in size, shape and dimensions; non-retentive; deeper than half a millimeter; involve both the enamel and dentin of vital teeth; the cavosurface margin cannot involve more than 50% of the enamel	Extremely poor oral hygiene; wearing orthodontic appliances; severe or chronic periodontitis; heavy bruxism habits; known allergy to resin-based materials or any other material used in this study; pregnant or lactating women; chronic use of anti-inflammatory drugs; analgesics and psychotropic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-62n9c3p	Gengival therapy to prevent bone necrosis	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7718	Effect of Injectable Platelet-Rich Fibrin Combined with Non-Surgical Periodontal Therapy in Oncology Patients Undergoing Bisphosphonate Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Faculdade de Odontologia de Ribeirão Preto da USP	Faculdade de Odontologia de Ribeirão Preto da USP	https://ensaiosclinicos.gov.br/rg/RBR-62n9c3p	<NULL>	Individuals of both sexes, adults or elderly, aged between 18 and 90 years who have undergone cancer treatment and received more than 3 doses of injectable bisphosphonates. Patients with bone metastases and multiple myeloma will be considered	Individuals will be excluded if they present any of the following conditions: (1) physical or mental illness at the time of the exam; (2) neurological disorders; (3) history of uncontrolled seizure or CNS or psychiatric disorder judged by the researchers to be clinically relevant before signing the informed consent form; (4) Who have undergone non-surgical periodontal therapy in the last six months before the study; (5) Patients previously submitted to head and neck radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-10b2vr39	Effect of using Supplements with Immunomodulatory Nutrients in the preoperative period of Major Surgeries	Recruiting	Intervention	2025-02-05	<NULL>	<NULL>	7719	Effectiveness of using an Immunomodulatory Formula in the preoperative period of Major Surgeries	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-01-05	Faculdade de Nutrição Emília de Jesus Ferreiro	Faculdade de Nutrição Emília de Jesus Ferreiro	https://ensaiosclinicos.gov.br/rg/RBR-10b2vr39	<NULL>	Individuals aged between 20 and 80 years; of both sexes; candidates for major elective surgeries followed on an outpatient basis at the Antônio Pedro University Hospital of the Fluminense Federal University (HUAP/UFF)	Participants will be excluded if they: cannot use the gastrointestinal tract as a feeding route during the study period; have amputated limbs; have previously consumed source foods or dietary supplements containing arginine, omega 3 and/or nucleotides on a regular basis, and/or in a dose and time different from that estimated by this study; have a history of allergy to cow&apos;s milk protein, fish and soy or lactose intolerance; have previously used probiotics, symbiotics or antibiotics during the last 2 months prior to the perioperative period; are in a condition of pregnancy or lactation; have severe organic dysfunctions (carriers of cardiovascular diseases, chronic kidney disease and neurodegenerative diseases); have received postoperative immunomodulatory enteral supplementation in a dose and time different from that stipulated in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-48qqsq2	Does Mental Fatigue caused by the use of social networks impair visual-motor skills of beach volleyball players? A randomized crossover study	Not yet recruiting	Intervention	2025-02-05	<NULL>	<NULL>	8225	Does Mental Fatigue caused by the use of social networks impair percepto-cognitive abilities of beach volleyball athletes? A randomized crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-09-10	Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba - CCS/UFPB	https://ensaiosclinicos.gov.br/rg/RBR-48qqsq2	<NULL>	Have been training beach volleyball for at least one year; have experience in official competitions; be training regularly for competitions; have not been diagnosed with neurological diseases; be between 15 and 21 years old; be male or female	Withdraw from participating for any reason; and/or suffer any type of injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-35y8dwr	Assessment of skin, vagina and penis acceptability with perceived efficacy	Not yet recruiting	Intervention	2025-02-04	<NULL>	<NULL>	7704	Orc_135676_en24-0630-01_assessment of dermal, urological and gynecological acceptability with perceived efficacy	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-20	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-35y8dwr	<NULL>	For the female audience: female participants aged 18 to 65 years; sexually active; with vaginal dryness; heterosexual couples in a stable union or civil marriage; intact skin on the vaginal mucosa; user of products of the same category; agreement to follow the trial procedures and attend the Clinical Research Center on the days and times determined for evaluations; understanding, consenting to and signing the Free and Informed Consent Form; for the male audience: male participants aged 18 to 65 years; sexually active; heterosexual couples in a stable union or civil marriage; intact skin on the penile region; user of products of the same category; agreement to follow the trial procedures and attend the Clinical Research Center on the days and times determined for evaluations; understanding, consenting to and signing the free and informed consent form	Pregnancy or risk of pregnancy and/or lactation (for women); participants with erectile dysfunction (for men); sexually transmitted infections, such as: candidiasis, trichomoniasis, gonorrhea, chlamydia or pathologies that compromise the evaluation of the safety of use of the product; use of anti-inflammatory/immunosuppressive/antihistamine drugs up to 3 weeks before selection; skin marks in the experimental area that interfere with the evaluation of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevi, sunburn); atopic or allergic history of products in the same category; active skin pathologies and/or lesions (local and/or disseminated) in the evaluation area; immunosuppression by drugs or active diseases; decompensated endocrinopathies; relevant clinical history or current evidence of alcohol or other drug abuse; known history or suspected intolerance to products in the same category; intense sun exposure up to 15 days before the evaluation; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; other conditions considered by the researcher as reasonable for disqualification from participation in the study. If so, it should be described in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-48zgwz5	Clinical evaluations of conventional and digital provisional removable partial dentures	Recruiting	Intervention	2025-02-04	<NULL>	<NULL>	7705	Conventional vs. digital provisional removable partial dentures: a randomized controlled crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-48zgwz5	<NULL>	Patients of both sexes; aged 18 or older; partially edentulous; who are interested in participating in the study for the installation of interim removable partial dentures; and who present good general health conditions	Patients with palatal or mandibular torus requiring surgical removal; cognitive disease; communication difficulties and who have trouble attending the university for prosthetic treatment and follow-up appointments; patients with temporomandibular dysfunction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-34t4kwg	Evaluation of the efficiency of 2% Alcoholic Chlorhexidine solution versus 2% Degerming Chlorhexidine solutions associated with 0.5% Alcoholic Chlorhexidine in reducing Infections of tunneled catheters for hemodialysis: an intervention study in time series	Recruiting	Intervention	2025-01-31	<NULL>	<NULL>	7703	Assessment of the effectiveness of using Chlorhexidine 2% Alcohol versus 2% Degerming Chlorhexidine + 0.5% Allcoholic Chlorhexidine in reducing Infections related to tunneled catheters for hemodialysis: a time series intervention study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-34t4kwg	<NULL>	All patients on hemodialysis using a long-term Central Venous Catheter (CVC) dialyzed at the Dialysis Unit of the Hospital das Clínicas of the Faculdade de Medicina de Botucatu (HCFMB) from January 2023 to January 2026; over 18 years old; both sexes	Pregnant patients; those under 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-283vnm6	Validate a device for diagnosing changes in the tooth after some challenges and treatments	Recruitment completed	Observational	2025-01-30	<NULL>	<NULL>	7696	Validation of a reflectometer for clinical detection of post-treatment enamel changes and erosive or abrasive challenges	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-283vnm6	<NULL>	Individuals aged 18 to 30 years; of both sexes; in good general health; non-smokers; not using medications regularly; non-pregnant women; and free from systemic diseases; with no erosive dental wear; active caries lesions; gingivitis; periodontitis; or any other oral condition that could affect saliva composition; as well as the presence of restorations or fixed appliances on the vestibular surfaces of the upper anterior teeth	Presence of risk factors for erosive tooth wear; volunteers with excessive consumption of carbonated beverages; fruit juices or acidic fruits; swimmers; or patients with gastric disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-96bp2pb	Clinical trial phase 1/2 to verify the safety of oral clarified açaí extract in acute ischemic stroke	Not yet recruiting	Intervention	2025-01-30	<NULL>	<NULL>	7697	Randomized and controlled clinical trial, single-center phase 1/2, to verify the safety of oral clarified açaí extract in acute ischemic stroke (AÇA-ICTUS study)	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2025-02-01	Instituto de Ciências da Saúde da Universidade Federal do Pará	Hospital da Aeronáutica de Belém	https://ensaiosclinicos.gov.br/rg/RBR-96bp2pb	<NULL>	Age 18 years or older; diagnosis of ischemic stroke on admission; absence of bleeding on admission cranial tomography; National Institute of Health Stroke Scale equal or higher than 5 on admission; possibility of administering treatment within 24 hours from the onset of symptoms	Previous moderate functional disability (modified Rankin Scale equal or higher than 3); indication of thrombolytic therapy (chemical, mechanical); inability to tolerate or accept study procedures; co-occurrence of other serious clinical emergencies/urgencies on admission (e.g., cardiopulmonary arrest, acute respiratory failure, septic shock, status epilepticus, signs of intracranial hypertension); National Institute of Health Stroke Scale equal or higher than 20 on admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-5x9434h	Effects of Class II Treatment with Orthodontic Aligners associated with Mandibular Advancement or the use of Intraoral Distalizers	Recruiting	Intervention	2025-01-30	<NULL>	<NULL>	7698	Effects of Class II Treatment with Orthodontic Aligners associated with Mandibular Advancement or Intraoral Distalizers: multicenter randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Universidade Anhaguera - UNIDERP	Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-5x9434h	<NULL>	Age between 10 and 14 years; both sexes; at least half Class II of Angle; convex facial profile, characterizing mandibular retrognathism; pronounced horizontal overjet, greater than 4 mm	Presence of craniofacial deformities; dental agenesis; active carious lesions; and previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-4x9j9hq	Effect of Caffeine on respiratory muscle in premature newborns	Data analysis completed	Observational	2025-01-30	<NULL>	<NULL>	7699	Effect of Caffeine Citrate on diaphragmatic electrical activity in pre-term newborns	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-07-19	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-4x9j9hq	<NULL>	Newborns; of both genders; preterm newborns with gestational age equal to or less than 28 weeks; newborns between 28 and 32 weeks of gestational age under  invasive or non-invasive ventilatory support; newborns with clinical diagnosis of apnea with gestacional age less than 37 weeks	Patients with major congenital malformations; anomalies of the upper digestive tract; primary neurological or drug-related abnormalities; newborns under high-frequency mechanical ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-2why5rd	Effects of laser therapy associated or not with mirror therapy on the functionality of the upper limbs and cognition of individuals who have suffered a Stroke	Data analysis completed	Intervention	2025-01-30	<NULL>	<NULL>	7700	Effects of Transcranial Laser Therapy associated or not with mirror therapy on the functionality of upper limbs and cognition in individuals affected by Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2why5rd	<NULL>	Both sexes; older than 18 years; clinical diagnosis of stroke in the chronic phase (more than six months); up to grade 2 on the Ashworth scale; ability to respond to simple commands using the least affected limb in pre-defined tasks; signed the Free and Informed Consent Form	Not having resources to travel to the study location; diagnosis of Transient Ischemic Attack; plegia; history of seizures and/or use of medication to control them; diagnosis of other associated neurological diseases; pregnancy; do not present motor sequelae in the upper limbs resulting from the stroke	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-7jw7z2g	Platelet-rich blood product or corticosteroid, which is better for treating partial shoulder injuries?	Not yet recruiting	Intervention	2025-01-30	<NULL>	<NULL>	7701	I-PRF vs Corticosteroid in the Treatment of Tendinopathy and Partial Tears (&lt;50%) of the Supraspinatus Muscle: double-blind clinical trials	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7jw7z2g	<NULL>	Age between 18 and 65 years old; Shoulder pain and/or lateral deltoid; At least 3 months of symptoms; Physical examination with positive JOBE test, no pain in the acromioclavicular joint and no symptoms of instability; Tendinopathy/partial injury (less than 50%) of the supraspinatus muscle tendon confirmed by magnetic resonance imaging (MRI); no prior surgical intervention; agreement with the Free and Informed Consent Form (TCLE)	Body mass index greater than 18 and less than 35 kg/m2; pregnancy or lactation; systemic diseases (DM – glycated hemoglobin greater than 6.5); hematological disease (anemia, coagulopathy, thrombophilia); hemoglobin less than 11g/dL; Hematocrit less than 33%; Platelets less than150,000/µL; presence of another disease that could cause pain and dysfunction in the shoulder, such as arthritis or bone injury; such as arthritis or bone damage; ipsilateral limb orthopedic disease; rheumatological disease; chronic kidney disease on dialysis. Respiratory pathology (Rhinitis, Asthma, Chronic obstructive pulmonary disease); oncological disease; fibromyalgia or psychiatric pathology under treatment; chemical dependency (smoking, alcoholism, others); use of non-steroidal anti-inflammatory drugs in the last 30 days; use of glucocorticoids in the last 3 months (systemic, articular, topical, inhaled); Use of anticoagulants or antiplatelet agents; Anesthetic risk: ASA greater than or equal 3; patients receiving social security benefits (sickness benefit); limitation of range of motion compared to the contralateral side; partial injury, such as fissure, partial, fissure-type injury, partial rupture less than 50% or total of the supraspinatus tendon proven by magnetic resonance imaging; presence of acromion hooked seen on MRI; patients unwilling or unable to provide Free and Informed Consent Form (TCLE)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-9wyk6t4	Comparison between Laser Cryosclerotherapy and Sclerotherapy in Varicose Vein treatment: success rate and side effects	Recruiting	Intervention	2025-01-30	<NULL>	<NULL>	7702	Randomized clinical trial comparing the CLaCS technique and Sclerotherapy for the treatment of Superficial Venous Disease of the lower limbs: comparing success rate and side effects	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade do Vale do Rio dos Sinos	Clinica Prime Vascular	https://ensaiosclinicos.gov.br/rg/RBR-9wyk6t4	<NULL>	Women; aged between 18 and 70 years; reticular veins and telangiectasias; without reflux of the deep venous or saphenous system; Fitzpatrick Skin Type I, II or III; Patients should have at least one reticular vein with a minimum length of 5 cm in one of the lower limbs on the lateral side of the thigh	Venous disease CEAP class greater than C1; who underwent procedure with sclerotherapy or transdermal laser in the last 12 months; skin classification Fitzpatrick IV, V or VI; pregnancy or puerperium; known allergy; peripheral arterial disease; diabetes; dermatitis at the treatment site; asthma; migraine; deep or superficial deep vein thrombosis (DVT); family history of DVT; known thrombophilia or any hypercoagulable state and use of anticoagulants; uncontrolled systemic disorders; patients who fail to attend their treatment sessions or follow-up visits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-4jwm3zw	Intervention program with working memory and reading for students with learning difficulties: development and pilot study	Data analysis completed	Intervention	2025-01-29	<NULL>	<NULL>	7693	Elaboration and verification of the therapeutic efficacy of an intervention program with the phonological and visuospatial working memory for schoolchildren with learning difficulties	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-03	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-4jwm3zw	<NULL>	Voluntary consent by signing the Free and Informed Consent Form; Female and male schoolchildren aged between 9 years and 10 years and 11 months; Presence of learning difficulties confirmed by standardised assessment procedures (lower performance of schoolchildren in tests of metalinguistic skills and reading - PROHMELE).	Previous participation in speech therapy, pedagogical or psycho-pedagogical intervention programs; Presence of genetic syndromes, intellectual disability and attention deficit hyperactivity disorder, described in school records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-4g8m6y7	Anti-Aging Treatment with PDRN and Growth Factors: Evaluation of Results and Safety	Recruiting	Intervention	2025-01-29	<NULL>	<NULL>	7694	Evaluation of the Efficacy and Safety of Anti-Aging Treatment with PDRN and Growth Factors	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2024-09-18	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-4g8m6y7	<NULL>	Patients of both sexes; diagnosed with facial sagging will be included in the study; aged between 20 and 80 years; and who have no contraindications for facial volumization procedures	Patients with a history of photosensitivity; keloids; hypertrophic scars; and post-inflammatory hyperpigmentation; as well as those who are pregnant or lactating; will be excluded from the study; Individuals with local inflammatory skin disorders or active herpes infection at the procedure site will also be excluded; as well as individuals with a history of medical conditions that contraindicate the procedures; such as intolerance to the components; urticaria; Raynaud&apos;s disease; or a history of allergic reactions to the components; Finally; patients who do not agree to participate in the study will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-8qkmmb4	Evaluation of Motor Learning and Its Relationship with Quality of Life, Participation, and Functionality in Adolescents with Cerebral Palsy	Data analysis completed	Observational	2025-01-29	<NULL>	<NULL>	7695	Assessment of the Motor Learning Process Using a Mobile Device and Its Relationship with Quality of Life, Participation, and Functionality in Adolescents with Cerebral Palsy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-10	Universidade Federal de Alfenas -UNIFAL	Universidade Federal de Alfenas -UNIFAL	https://ensaiosclinicos.gov.br/rg/RBR-8qkmmb4	<NULL>	Age between 12 and 17 years. Both sexes. Classified at levels I, II, III, or IV of the Gross Motor Function Classification System. At levels I, II, or III of the Manual Ability Classification System. Participants with expected performance for their educational level, as assessed by the Nonverbal General Intelligence Test BETA III, in the subtests Matrix Reasoning – Nonverbal Intelligence and Processing Speed. Those scoring above the 10th percentile and with basic knowledge of numbers from 1 to 30 as a supplementary criterion. Adolescents regularly enrolled at Dr. José Vargas de Souza Municipal School.	Those classified at level V of the Gross Motor Function Classification System, at levels IV and V of the Manual Ability Classification System. Those with severe cognitive impairment that hindered the execution of activities. Adolescents with any evident or diagnosed sensory, motor, or cognitive deficits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-4zhxxhd	Longitudinal analysis of children and adolescents with radiographic bone alterations in the milk tooth phase treated at the Piracicaba Dental School	Not yet recruiting	Observational	2025-01-28	<NULL>	<NULL>	7688	Longitudinal analysis of children and adolescents with radiographic bone alterations in deciduous dentition treated at the Piracicaba Dental School	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-02	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4zhxxhd	<NULL>	"Individuals treated at the Piracicaba Dental School identified with a radiographic distance between the alveolar bone crest and the cementoenamel junction greater than 2 mm and parents and biological siblings;age from 5 years;any gender

Controls: Individuals treated at the Piracicaba Dental School identified with a radiographic distance between the alveolar bone crest and the cementoenamel junction equal to or less than 2 mm, and close relatives (parents and biological siblings)."	Motor impairments that hinder oral hygiene;use of fixed orthodontic appliances;continuous use of anti-inflammatory and or systemic antimicrobial medications in the past 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-9fnhzqw	Effects of Physical Exercise on Patients Treated with Drugs for Breast Cancer	Not yet recruiting	Intervention	2025-01-28	<NULL>	<NULL>	7689	Effects of Physical Exercise during Chemotherapy in Patients with Breast Cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-02	Bruno Gama Linhares	Faculdade de Medicina de Campos - Fundação Benedito Pereira Nunes	https://ensaiosclinicos.gov.br/rg/RBR-9fnhzqw	<NULL>	Women over 18; histological diagnosis of stage IA-IIIC breast carcinoma; scheduled to receive chemotherapy with anthracyclines or trastuzumab; be able to understand and accept informed consent; breast cancer patients	Contraindications for exercise testing, decompensated comorbidities; pre-existing heart disease, pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-4gkp27w	Effect of laser therapy in the treatment of paresthesia in patients undergoing orthognathic surgery and wisdom tooth extraction	Recruitment completed	Intervention	2025-01-28	<NULL>	<NULL>	7690	Effect of photobiomodulation in the treatment of paresthesia in patients undergoing orthognathic surgery and third molar extraction: randomized, triple-Blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-09	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4gkp27w	<NULL>	Will be included, adults aged between 18 and 60 years; of both sexes and regardless of color or social class; with a main complaint of inferior alveolar nerve paresthesia who underwent orthognathic surgery or third molar extraction; who seek or are referred to &quot;Laboratório Especial de Laser em Odontologia da Universidade de São Paulo&quot; for the treatment of paresthesia; to all participants will be asked to sign the free and informed consent form	Participants with paresthesia unrelated to orthognathic surgery or third molar extraction will be excluded; patients who also present lingual nerve paresthesia; patients with sensory changes reported before surgery or with a history of injury to trigeminal nervous tissue due to other interventions; patients who present paresthesia of the maxillary and/or mandibular branches of the trigeminal nerve and are undergoing some other type of treatment for paresthesia (Acupuncture; systemic medication; local physiotherapy; electrical stimulation); be using antidepressant or anxiolytic medications, and pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-7bt6dxb	Effects of physical exercise on kidney function, daily living skills and quality of life in people with Chronic Kidney Disease	Recruitment completed	Intervention	2025-01-28	<NULL>	<NULL>	7691	Chronic effects of strength training with blood flow restriction on glomerular function, functional capacity and perceived quality of life in people with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Empresa Brasileira de Serviços Hospitalares - EBSERH	Hospital Universitário Professor Alberto Antunes da Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-7bt6dxb	<NULL>	volunteers with stage 3 chronic kidney disease; both sexes; aged between 35 and 75 years; without a diagnosis of Hepatitis C or B; without flu-like syndromes; without coagulation dysfunction or signs of thrombophlebitis; without severe arrhythmia, angina or cerebrovascular or cardiovascular disease; without pulmonary congestion or peripheral edema; ankle-brachial index within normal standards	volunteers who suffer from any hypokinetic or osteoarticular disease or cardiovascular events during the intervention; medical recommendations to leave the study; attendance of less than 85% of the sessions planned for the intervention; personal needs and wishes to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-10ns38c6	The effect of Cold Plasma Activated Solution on the face to treat Skin aging	Recruiting	Intervention	2025-01-28	<NULL>	<NULL>	7692	Permeation of Plasma-Activated Solution in the Treatment of Skin aging	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-10ns38c6	<NULL>	Female patient; age between 40 and 60 years; phototype II, III, and IV according to the Fitzpatrick scale; presence of signs of facial photoaging grade I to IV according to the Glogau scale; Signed informed consent	Active infections such as herpes at the site where the procedure is performed; with tendencies to keloid healing and hypertrophic scarring; Pregnant; Rosettes; skin cancer; uncontrolled diabetes; use of some type of cosmetic in the facial region in the last six months, whose indication is for the minimization of facial aging, such as: Antioxidant, Kojic Acid, Salicylic Acid and Retinol; performance of rhytidoplasty and/or blepharoplasty, and ablative chemical or physical peeling in the last 12 months; and, use of botulinum toxin or fillers with collagen implants in the last six months; patients using photosensitizing drugs; patient with impossibility of photoprotection during the entire treatment period; patients with active skin diseases in the facial region; presence of implanted electronic or metallic devices; patient with suspected or diagnosed photosensitive epilepsy; Refusal to sign the free consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-4p5mr8c	Study on the effectiveness and tolerance of nanotechnological products based on medicinal plants in ulcers of patients with diabetes	Not yet recruiting	Intervention	2025-01-27	<NULL>	<NULL>	7683	Study of the effectiveness and clinical tolerance of nanotechnological products from volatile oils of Salvia rosmarinus and Larix decidua in planter ulcers of diabetic people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital Universitário da Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4p5mr8c	<NULL>	Adult males or females. ≥ 18 years of age. Signed written informed consent. Diagnosis of type 1 or 2 diabetes mellitus. HbA1c ≤ 86 mmol/mol (≤ 10%) at screening. Subjects with at least first time with a full-thickness ulcer or recurrent ulcer (below the ankle) that fulfills all of the following criteria at screening and at the start of the protocol: A non-Interdigital wound. Accessible for administration of the products, tests, evaluations, and wound study procedures. Persistence of the wound for at least 6 weeks prior to the start of the protocol. Complete minimal skin ulcer without detachment, without muscle, tendon, or bone exposure. A wound area of 1.0 - 5.0 cm2 after cutting or mechanical debridement at screening. During the 2 weeks between the start of the initial phase and baseline, the wound size should not decrease by more than 30% or increase by more than 25%, which corresponds to wound areas of 0.7 - 6.3 cm2. Pressure on the tip of the foot ≥30 mm Hg. Diabetic patients who present neuropathic and/or ischemic ulcers without infection at any stage of healing. Willing to refrain from using unapproved lotions or creams on the site of injury and the surrounding area during the treatment period. Willing to refrain from washing the treated area for at least 8 hours after application of study medication. Laboratory values for the tests listed below within protocol-defined reference ranges, or &quot;out of range&quot; test results that are clinically acceptable for study participation. Ability to follow study instructions and likely complete all study requirements. Agree to participate in the research by signing the Informed Consent Form	Be under 18 years old. Pregnant or breastfeeding. Patients who do not fit into the ulcer classification stipulated for the study (severe injuries with deep infection, or with indication for amputation). Patients with cognition problems that make it difficult to apply treatment. Concomitant disease or treatment that suppresses the immune system. Chronic medical condition that, without the judgment of the investigator(s), would disrupt study performance or place the patient at undue risk. Known sensitivity to any of the components of the study medication. Treatment with systemic chemotherapy agents in the 6 months prior to selection. Use of systemic retinoids in the 6 months prior to the screening period. the leg presenting the planned or performed wound within 8 weeks prior to screening. Has any disease conditions, including ulcerative dermatologic disorders and vasculitis, or comorbidities that may preclude the subject from participating in the study or confound assessment of the safety profile and effect on wound healing. Female subjects of childbearing potential unless using a contraceptive method with a failure rate &lt; 1% to prevent pregnancy. Patients who do not have continuous monitoring by their family or caregiver and those who cannot attend within the specified period for evaluation and dressing changes (lost to follow-up)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-3p6tr4n	The effects of prayer on pain thresholds and scores of anxiety and depression in patients with migraine and control: A randomized clinical trial	Recruiting	Intervention	2025-01-27	<NULL>	<NULL>	7684	The effects of prayer on pain thresholds and scores of anxiety and depression in patients with Migraine and control: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-29	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3p6tr4n	<NULL>	The inclusion criteria for this project is having a diagnosis of chronic or episodic migraine and feeling comfortable performing a known prayer. People who consider themselves religious and non-religious, spiritual and non-spiritual can participate. Female and male participants. Aged 18 to 60 years	Exclusion criteria will be severe acute circulatory disorders, decompensated diabetes mellitus and cognitive weaknesses that prevent the patient from understanding and carrying out the study procedures. In addition to the use of analgesics in the 24 hours prior to the algometry assessment. The exclusion criteria will be previously verified using a form sent to the potential participant and confirmed in the first evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-7zkj67z	The role of physiotherapy in the quality of life and functional capacity of cancer patients undergoing palliative treatment	Recruitment completed	Intervention	2025-01-27	<NULL>	<NULL>	7685	Analysis of the influence of physiotherapy exercise on the quality of life and functional capacity of cancer patients in palliative treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Fundação Doutor Amaral Carvalho	Hospital Amaral Carvalho / Fundação Doutor Amaral Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-7zkj67z	<NULL>	Hospitalization for at least 7 days; be 60 years of age or older; pain according to Visual Analogue Scale (VAS) between 3 and 7; Modified Borg Scale between 0 and 7; Karnofsky (KPS – Karnofsky Performance Status) we will use between 30% and 70%; ECOG (Eastern Cooperative Oncology Group performance status) between 1 and 3	Need for sedoanalgesia; discharged before 7 days of hospitalization; signs of intense respiratory discomfort requiring absolute rest; evolution to death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-3jhv37y	Adapted strength and balance training for institutionalized and non-institutionalized elderly: effects on strength, performance, and balance	Recruiting	Intervention	2025-01-27	<NULL>	<NULL>	7686	Effects of a strength and balance training protocol in different groups of elderly people	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Pontifícia Universidade Católica do Parana - PUCPR	Pontifícia Universidade Católica do Parana - PUCPR	https://ensaiosclinicos.gov.br/rg/RBR-3jhv37y	<NULL>	Elderly individuals over 60 years old; of both sexes; who have not participated in strength and balance exercise programs for at least six months; must be physically capable of performing physical tests; and have medical clearance to participate in exercises	Elderly individuals who are unable to perform the physical tests; engage in any type of strength and balance exercises not included in the present study; or report any injury during the training period will be excluded; those who fail to attend at least 75% of the total training sessions will be considered sample loss.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-9vsvkn5	Wheelchair mattress and cushion evaluation for pressure ulcer prevention	Not yet recruiting	Intervention	2025-01-25	<NULL>	<NULL>	7680	Evaluation of the C-CORE surface in the prevention of pressure injuries	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Escola de Enfermagem da Universidade Federal de Minas Gerais	Escola de Enfermagem da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9vsvkn5	<NULL>	Healthy adults; both genders; be over 18 years of age; have all limbs (upper and lower; be a non-smoker for at least one year; have the ability to move independently in bed and maintain supine and prone positions	Having a body height or width exceeding the size of the bed (2.0 x 0.85 m); presence of dermatological conditions involving scaling; skin wounds, or scars in areas of bony prominences (pressure measurement sites); or exhibiting pronounced spinal deformities upon inspection (lordosis or scoliosis)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-6yk2kgv	Ahmed ClearPath and Baerveldt non-valved drainage devices in the treatment of Glaucoma	Recruiting	Intervention	2025-01-25	<NULL>	<NULL>	7681	Efficacy and safety of implanting Ahmed ClearPath and Baerveldt non-valved drainage devices in the treatment of refractory and/or high-risk Glaucoma. Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6yk2kgv	<NULL>	Best-corrected visual acuity of Light Perception (LP) or better, with good light projection. Diagnosis of refractory glaucoma by the attending physician: intraocular pressure not clinically controlled with maximum tolerated therapy, presence of previous fistulizing glaucoma surgery or cataract surgery, contraindication to fistulizing surgery. Indication for drainage tube implantation by the attending physician, with or without association with cataract surgery or vitrectomy. Age 18 years or older. Both sexes	Under 18 years of age. Previous drainage tube implantation procedure. Presence of retinal and/or choroidal detachment. Visual acuity with no light perception. Presence of ocular tumor. Patients unable to undergo the proposed examinations or to remain in the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-7dj4mt3	Counseling and Physical Exercises: effects on the Health of pregnant women during prenatal care	Not yet recruiting	Intervention	2025-01-25	<NULL>	<NULL>	7682	Impact of Counseling and Physical Exercises on biomarkers and health indicators of pregnant women in prenatal care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Jataí	Secretária Municipal de Saúde de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-7dj4mt3	<NULL>	Pregnant women registered at the basic unit and undergoing prenatal care; have completed 12 weeks of pregnancy; are aged 18 or over; live in the municipality of Jataí-GO	Pregnant women with clinical comorbidities (hypertension and diabetes); multiple pregnancies; pregnant women with intellectual disabilities identified by a health professional, reported by a companion, or perceived when answering the study instruments; having self-reported or perceived motor limitations that do not allow them to perform motor and functional tests and physical exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-92y48wx	Tests to prove the efficacy and safety of Bandage Active Gueds in humans affected by vascular wound	Recruiting	Intervention	2025-01-24	<NULL>	<NULL>	7679	Single-blind clinical study on the efficacy and safety of the Gueds Active Bandage	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-31	Instituto de Saúde e Bem Estar da Mulher	Nipo Serviços Médicos SS Ltda	https://ensaiosclinicos.gov.br/rg/RBR-92y48wx	<NULL>	Participating patient who has Venous Vascular Ulcers and/or Lymphatic Edema. Whit woounds that require bandages and compression bandages. Age between 18 and 80 years. Any ethinicity, color/race, phototypes. Both sexes	Pregnancy. Neonates (0 to 1 year old). Sensitivity to the components of the medicine. Patients with ulcers caused by diabetes mellitus, arterial ulcers and mixed ulcers. Carrier of weakened limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-2yd7sy5	Use of probiotics to help treat gingivitis	Not yet recruiting	Intervention	2025-01-23	<NULL>	<NULL>	7676	Use of probiotics as adjuvant in gingivitis treatment: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-20	Universidade Iguaçu	Universidade Veiga de Almeida	https://ensaiosclinicos.gov.br/rg/RBR-2yd7sy5	<NULL>	Healthy volunteers; non-smokers; of both genders; over 18 years of age; must present Gingivitis characterized by the presence of gingival bleeding in more than 10% of the sites evaluated	Cigarete smokers; history of previous periodontal treatment; antibiotics use within the past 6 months; pregnancy; presence of acute or necrotizing lesions; history of diabetes; rheumatic fever; neurological deficiencies; immunological diseases; use of medications that affect periodontal tissues such as phenytoin, cyclosporine, nifedipine and anti-inflammatories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-10mdc4h7	Effects of taurine consumption on the physical performance of professional soccer players	Data analysis completed	Intervention	2025-01-23	<NULL>	<NULL>	7678	Effects of acute Taurine consumption on physical performance parameters in professional soccer athletes: a triple-blind, randomized, crossover clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-23	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10mdc4h7	<NULL>	To be a football (soccer) athlete; participate in the Under-20 category (ages 17 to 20); be involved in football competitions; have at least two years of formal and systematic experience in the sport prior to the start of the study	Presence of bone and/or muscle injury; history of recent musculoskeletal injuries; use of anti-inflammatory medication; use of taurine or caffeine-based supplements 24 hours before the protocols; presence of any disease in the central nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-2dsmhsq	rTMS and  Treadmill Training in children with Spastic Cerebral Palsy	Recruiting	Intervention	2025-01-22	<NULL>	<NULL>	7672	Neuromodulation of the primary motor cortex by rTMS and Treadmill Training in children with Spastic Serebral Palsy: a randomized, double-blinded, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Universidade Evangélica de Goiás	Follow Kids - Clinica de Neuro Reabilitação Infantil	https://ensaiosclinicos.gov.br/rg/RBR-2dsmhsq	<NULL>	Diagnosis of spastic cerebral palsy; functional classification on Levels I, II or III of the Gross Motor Function Classification System (GMFCS); ability to walk independently in at least the previous 12 months, even if requiring a gait-assistance device; age between six and 12 years; degree of understanding and cooperation compatible with the execution of the proposed activities; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-6ynw9d6	Effect of Aromatherapy on tiredness, insomnia and quality of life of patients with Breast and Gastrointestinal Cancer undergoing chemotherapy	Recruiting	Intervention	2025-01-22	<NULL>	<NULL>	7673	Effect of Aromatherapy on fatigue, sleep quality and quality of life in patients with Breast and Gastrointestinal Cancer undergoing chemotherapy treatment: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-05	Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6ynw9d6	<NULL>	Patients of both sexes; diagnosed with Breast or Gastrointestinal Cancer; over 18 years of age; who will begin the chemotherapy protocol	Patients who use sleep inducers; with cognitive deficit; who already use aromatherapy or who are allergic to Lavender or Bergamot essential oil	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-4gxpv7w	Musical drums adapted with Mirror Therapy: therapeutic toy to improve movement, muscle strength and quality of life of children with  Cerebral Palsy	Recruiting	Intervention	2025-01-22	<NULL>	<NULL>	7674	Musical drums adapted with mirror therapy: innovative therapeutic toy to improve range of movement, muscle strength and quality of life of children with unilateral cerebral Palsy	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-30	Faculdade de Ciências Médicas de Minas Gerais	Faculdade de Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4gxpv7w	<NULL>	Children and adolescents of both sexes; aged 6 years or older and under 14 years old; diagnosed with Unilateral and Bilateral Cerebral Palsy; classified as levels I II and III of the Gross Motor Function Classification System and as levels I II III of the Manual Ability Classification System for Children with Cerebral Palsy	Patients with cognitive disorders that impair the ability to understand simple commands; who have undergone surgical procedures; botulinum toxin injections in the upper limbs in the last 6 months; who have other neurological disorders or musculoskeletal disorders that may interfere with the response to ROM muscle strength  manual dexterity tests; as well as the application of the quality of life questionnaire; participants who have visual and auditory alterations that prevent visual and auditory feedback during the use of the adapted therapeutic toy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-9w5zzdh	Comparative study: Pericardio Bovino Vivendi versus native tissue in the treatment of pelvic prolapse	Recruiting	Intervention	2025-01-22	<NULL>	<NULL>	7675	&quot;Prospective, Randomized, Multicenter Comparative Study: Vivendi L-hydro - Labcor Graft versus Native Tissue in the Treatment of Pelvic Organ Prolapse in Women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Hospital Municipal Maternidade -Escola Doutor Mário de Moraes Altenfelder Silva	https://ensaiosclinicos.gov.br/rg/RBR-9w5zzdh	<NULL>	Women. Age between 18 and 80 years. Report of an uncomfortable bulge in the vaginal area that the patients can feel or see. Pelvic Organ Prolapse grade 3 or higher, anterior, apical, and vault types. The patient or legally authorized representative must agree and provide written informed consent. Be literate. Have accepted the invitation and understood the information contained in the informed consent form. Participant capable and agreeable to follow the established follow-up regimen	Informed consent form. Patients who withdraw from the study. Active or chronic infection, including gynecological infection, urinary tract infection, or local tissue necrosis. History of pelvic organ cancer (uterine, ovarian, bladder, colorectal, or cervical). History of radiotherapy and/or chemotherapy in the pelvic region. Use of systemic steroids in the last month or immunosuppressive or immunomodulatory treatment in the last 3 months. Systemic connective tissue disease (Scleroderma, Systemic Lupus Erythematosus, Marfan Syndrome, Ehlers-Danlos Syndrome, Collagenosis, Polymyositis, Rheumatic Polymyalgia). Neurological disease with neurogenic dysfunction of the lower urinary tract (Multiple Sclerosis, Spinal Cord Injury, or Stroke). Previous prolapse surgery with mesh in the target compartment. Skeletal alteration that prevents positioning in lithotomy. Chronic pelvic pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-3bgs2m2	Comparison between two Threads for Facial Suspension through the temple	Data analysis completed	Observational	2025-01-21	<NULL>	<NULL>	7671	Comparison between two Suture Threads in Temporal Endoscopic Facial Suspension	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-20	Universidade Palista - UNIP	Universidade Palista - UNIP	https://ensaiosclinicos.gov.br/rg/RBR-3bgs2m2	<NULL>	Women. Age 49 to 69 years. Not have performed any aesthetic procedure involving the use of botulinum toxin, injectable fillers of any nature and facial threads and/or sutures in the last 48 months. The result of the FACE-Q Questionnaire - Satisfaction with Facial Appearance should be a final value between 10 and 20 points. Have a medical release form. Absence of systemic, uncontrolled comorbidities. Ability to join the visiting scheme. Commit not to receive any other aesthetic procedure on the face during the study period (18 months)	Indication of rehabilitative dental treatment. Underlying disease or clinical condition that impairs the sequence of study procedures. Have some neuropathic disease. Have bruxism or clenching. Being pregnant. Allergy to any medication used. History of an eating disorder or any other condition and/or disorder related to image or physical appearance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-96b5zp9	Clinical and laboratory evaluation of resin materials containing bioactive particles	Not yet recruiting	Intervention	2025-01-17	<NULL>	<NULL>	7667	Clinical and in vitro performance of resin materials containing the bioactive particle S-PRG	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal do Paraná - UFPR	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-96b5zp9	<NULL>	Participants can be male or female; must be at least 18 and no more than 65 years old; have good oral hygiene; absence of periodontal disease; have at least 20 teeth in occlusion and of these three or more teeth must present noncarious cervical lesions (NCL) of the abfraction type; the lesions should be approximately 2 mm deep	Participants with caries activity; unsatisfactory oral hygiene conditions; severe bruxism or other parafunctional habits; periodontal disease and systemic complications; participants who have undergone orthodontic or hypersensitivity treatments in the past six months will be excluded; in addition to pregnant and lactating women; teeth with abfraction lesions that have an implant or total prosthesis as an antagonist will also not be included in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-2rg97kz	How Strength Training Can Improve Cardiovascular Health and Reduce Symptoms of Obstructive Sleep Apnea and Impact on Disease Severity, Blood Pressure, and Heart Health	Recruiting	Intervention	2025-01-17	<NULL>	<NULL>	7668	Effect of Strenght Training on Disease Severity, blood Pressure, arterial stiffness and autonomic modulation in adults with Obstructive Sleep Apnea	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-23	Pronto S.Cardiologico de Pe.Prof.Luiz Tavares - PROCAPE	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2rg97kz	<NULL>	Patients of both sexes will be included; with obstructive sleep apnea diagnosed through full-night polysomnography; with moderate to severe disease severity (Apnea-hypopnea index ≥ 15 events/hour); who are over 18 years old; and are not undergoing prior treatment for obstructive sleep apnea; patients must have a body mass index ≥ 25 kg/m²	Patients with uncontrolled hypertension (160mmHg systolic and 100mmHg diastolic); musculoskeletal diseases that prevent the intervention; as well as patients with chronic obstructive pulmonary disease; and patients participating in other supervised or unsupervised interventions; as well as those using continuous positive airway pressure, will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-8x8nmb4	Evaluation of the use of 2% tofacitinib in the treatment of non-pustular psoriasis on the hands and feet: a placebo-controlled clinical study	Not yet recruiting	Intervention	2025-01-17	<NULL>	<NULL>	7669	Efficacy of 2% tofacitinib ointment in the treatment of non-pustular palmoplantar psoriasis: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Estadual do Oeste no Paraná (UNIOESTE)	Universidade Estadual do Oeste no Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-8x8nmb4	<NULL>	Eligibility criteria for participation in the study include: adult individuals of both sexes; age between 18 and 60 years; clinical diagnosis of palmoplantar non-pustular psoriasis and active lesions at the time of inclusion; presence or history (documented by a dermatologist) of at least one additional plaque of psoriasis in another region of the body; a washout period of at least two weeks from the use of other topical medications that could affect psoriasis	The following participants will be excluded: patients with pustular psoriasis, erythrodermic psoriasis, or drug-induced psoriasis; evidence of other skin diseases that could affect the assessment of palmoplantar non-pustular psoriasis or the response to treatment; pregnant women; breastfeeding women; individuals with a known sensitivity to JAK inhibitors or to the vehicle/placebo; individuals using systemic JAK inhibitors; evidence of latent, active, or inadequately treated tuberculosis; hepatitis B or C infection; HIV (Human Immunodeficiency Virus) infection; history of disseminated or recurrent herpes zoster; history of infection requiring hospitalization or treatment with oral or topical antimicrobials within 2 weeks before baseline; history of lymphoproliferative disorders or malignancies (except for excised basal cell carcinoma or squamous cell carcinoma); history of thrombophilia; individuals using potent or moderate CYP3A4 inhibitors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-3wn6k3p	Gastrointestinal issues caused by metformin use: what are the treatment alternatives?	Not yet recruiting	Intervention	2025-01-17	<NULL>	<NULL>	7670	Occurrence of gastrointestinal adverse events and the use of metformin hydrochloride: are there other management options?	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2025-03-03	Universidade Federal de São João del-Rei	Universidade Federal de São João del-Rei	https://ensaiosclinicos.gov.br/rg/RBR-3wn6k3p	<NULL>	Male and female patients will be recruited. Age over 18 years. Patients using 500 mg immediate-release metformin hydrochloride for the first time	Pregnant women. Patients with a history of or declared allergies to folic acid. Those considered incapable of completing the adverse event perception form accurately: for the latter exclusion criterion, the patient&apos;s level of education and the presence or absence of a caregiver will be considered	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-72mvv89	Effect of medication use after video-assisted nose surgery: experimental clinical study	Recruitment completed	Intervention	2025-01-16	<NULL>	<NULL>	7665	Effects of use of Intranasal Blue®M Solution in Post-Operative Endonasal Endoscopic Surgery: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Hospital Paranaense de Otorrinolaringologia	Hospital Paranaense de Otorrinolaringologia	https://ensaiosclinicos.gov.br/rg/RBR-72mvv89	<NULL>	Patients with chronic rhinosinusitis unresponsive to clinical drug treatment; patients with indication for endoscopic sinus surgery; older than 18 years	Patients who have a history of prior sinonasal surgery; patients with a history of smoking;  patients with a history of systemic diseases that compromise the airway or irregularities in mucociliary transport, such as asthma or cystic fibrosis; patients with upper airway infection during the three weeks prior to surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-7w2yvfp	Direct Tracks to correct Unilateral Crossbite in children	Not yet recruiting	Intervention	2025-01-16	<NULL>	<NULL>	7666	Planas Direct Tracks (PDT) compared with no intervention for correction of Functional Posterior Crossbites in children: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-17	Associação Brasileira de Odontologia secção Bahia	Associação Brasileira de Odontologia secção Bahia	https://ensaiosclinicos.gov.br/rg/RBR-7w2yvfp	<NULL>	Children between 4-5 years of age, both sexes; who have Posterior Crossbites Functional; and do not yet have the first permanent molar erupted; posterior unilateral crossbite defined as minimum two crossed posterior teeth; deviation of mandibular position from contact in centric occlusion to position of maximum intercuspation accompanied by line deviation average of at least 1mm; perimeter compatibility between the arches, that is, in position centric relationship, the maxilla should not exceed the mandible by more than 2mm; children who have eliminated finger-sucking and/or pacifier habits due to fur least 6 months until the exam date; children whose parents sign an informed consent form after the carrying out the exams	Children with cleft lip and/or palate; syndromes or neurological diseases associated with craniofacial anomalies or dental ankylosis; children with anterior crossbite or class III skeletal relationship; previous orthodontic treatment; caries or extensive restorations, with mesio-distal or disto-vestibular involvement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-55zwb45	Comparison between measurements the Peripherally Inserted Central Catheter in children and newborns	Recruiting	Intervention	2025-01-15	<NULL>	<NULL>	7663	Comparison between two methods of measuring the Peripherally Inserted Central Catheter in pediatric and neonatal patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-17	Escola de Enfermagem - Universidade Federal de Minas Gerais	Hospital Metropolitano Odilon Behrens	https://ensaiosclinicos.gov.br/rg/RBR-55zwb45	<NULL>	Neonates and children aged to 12 years (ver emenda); both genders; with Peripherally Inserted Central Catheter - PICC Insertion procedure in upper limbs; who agree to participate in the study	Peripherally Inserted Central Catheter insertion procedure in lower limbs, external jugular veins and temporal and auricular veins; procedures performed in patients with congenital anomalies that present variations in the venous network or displacement of the anatomical location of the heart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-6pzvnt8	Assessment of pain, quality of life and success of root canal treatment after different cleaning methods: randomized clinical trial	Recruiting	Intervention	2025-01-15	<NULL>	<NULL>	7664	Assessment of postoperative pain, quality of life and success of endodontic treatment after different irrigant activation protocols: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-11	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pzvnt8	<NULL>	Participants will be selected at the Faculty of Dentistry of the University of São Paulo (FOUSP); individuals classified by the American Society of Anesthesiology as ASA I and II; aged between 18 and 60 years old; both genders; single-rooted teeth with single canal; diagnosis of pulp necrosis; evidence of symptomatic or asymptomatic apical periodontitis; radiolucency with a minimum diameter of 2 x 2 mm based on the initial periapical radiograph	Individuals classified by the American Society of Anesthesiology as ASA III or higher; pregnancy; allergies to local anesthetics, sodium hypochlorite, latex, or Ibuprofen; tooth with probing depth greater than 3mm; mobility score grade 2 or higher; subgingival fracture or caries that makes absolute isolation difficult or is not capable of definitive restoration; root fracture; any type of root resorption; incompletely formed root apex; endodontic treatment performed; individuals who took analgesic or anti-inflammatory medication that could alter pain perception within at least 12 hours before the start of the treatment session or those who took antibiotic medication 2 weeks before the start of treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-52rrmwg	Impact of bone graft and membrane on maintaining alveolar bone structure in diabetic patients after tooth extraction	Recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7656	Efficacy of Alveolar Ridge Preservation with Xenograft Combined with Collagen Membrane in Diabetic Patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade de São Paulo	Bioinovação Biomédica Limitada	https://ensaiosclinicos.gov.br/rg/RBR-52rrmwg	<NULL>	The study will include participants of both genders; aged between 18 and 70 years; who have been diagnosed with type II diabetes mellitus and present HbA1c levels between 6% and 10% (ASA II); must need the extraction of upper dental elements (excluding molars) and lower dental elements (excluding molars and incisors); performed using the closed technique; have no active periapical and/or periodontal infection	Individuals with other metabolic diseases that negatively impact bone metabolism, such as osteoporosis and hyperparathyroidism; participants who fail to attend follow-up appointments or those whose extraction procedures require bone tissue removal (osteotomy); experience any intraoperative complications, such as root fracture, bone fracture, loss of alveolar integrity, or hemorrhage, will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-2stdy4v	Effect of physical exercise on postural control and locomotor performance in people with hemophilia	Not yet recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7657	Effect of physical exercise, functional capacity, postural control and kinematic analysis of locomotor performance during obstacle overcoming associated with gripping movement in people with hemophilia	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Educação Física e Desportos da Universidade Federal do Espírito Santo - Campus Goiabeira	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-2stdy4v	<NULL>	Volunteers with Hemophilia A or B; Mild to Moderate or Severe Projects; male; body mass index less than 30	History of hip; knee; and ankle surgery; inability to walk with or without a device such as a cane or walker; history of bleeding into muscles or joints in the past 2 months; respiratory or neurological disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-32dp35h	Effects of sitting time on blood circulation, blood pressure, and muscle activity in adults	Recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7658	Cardiometabolic and cardiovascular responses, strength, and muscle electrical activity during multistage prolonged sitting in sdults	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-08-02	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-32dp35h	<NULL>	Healthy young adults aged between 18 and 50 years; Absence of previous diagnosis of chronic diseases, such as diabetes mellitus (type 1 or type 2), hypertension, cardiovascular diseases, neuromuscular or metabolic disorders; No use of continuous medications, including antihypertensives, antidiabetics, anti-inflammatory drugs, beta-blockers, or any other medication that may influence metabolism, the cardiovascular system, or muscle function; No use of supplements or ergogenic substances (e.g., creatine, caffeine, beta-alanine) in the 30 days prior to participation in the study; Absence of musculoskeletal injuries, chronic pain, orthopedic conditions, or any other physical limitation that prevents prolonged sitting (minimum of 3 hours); Consent to follow all research protocol guidelines, with availability to participate in the experimental session and complete all study stages	Interruption or non-completion of any phase of the study, including initial screening, anthropometric assessments, reference tests, or the experimental session; Development of any acute condition (e.g., fever, infection, acute injury) or diagnosis of a chronic condition during the screening and data collection period that may interfere with the study outcomes; Intake of alcohol, caffeine, medications, or ergogenic supplements within the 24 hours prior to the experimental session; Participants with elevated levels of sedentary behavior (e.g., more than 12 hours/day sitting) or engaging in vigorous physical activity (&gt;300 minutes/week) that may influence the study results; Exposure to environmental conditions that may alter thermoregulation or cardiovascular function (e.g., sunburn, hot baths close to the experimental session)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-542hj35	Quality of Cardiopulmonary Resuscitation performed by nursing professionals	Recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7659	Analysis of the quality of Cardiopulmonary Resuscitation performed by nursing professionals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-03	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-542hj35	<NULL>	Nursing professionals; age over 18 years;  both female and male; from units providing care to adults at the institution; who wish to participate in all stages of the research	Instructors of Basic or Advanced Life Support courses; professionals who have completed another Basic or Advanced Life Support course between the steps of the study; individuals with health problems that impair the performance of CPR skills, or those who are pregnant at the time of data collection and individuals who do not fully participate in any of the stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-9krffvx	Comparison of Two Methods for Securing Subcutaneous Access and Their Effects on Comfort and Safety of Patients in Palliative Care	Not yet recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7660	Effects of two Hypodermoclisis fixation techiniques on the occurrence of adverse event, length of stay and their implications for patient comfort in palliative care: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Federal de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-9krffvx	<NULL>	patients of both sexes; from 18 years of age; with a medical prescription for hypodermoclysis; who do not have a diagnosis of skin changes; who do not have a known history of allergy to the tape used	Patients who develop an allergy to the tape used; are transferred to another unit will be discontinued from the sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-3q6jfwp	Comparative study of different therapeutic modalities for controlling postoperative pain in proximal femur surgery	Not yet recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7661	Comparative study between pericapsular nerve block (PENG BLOCK) associated with the lateral femoral cutaneous nerve, iliac fascia block and intrathecal morphine in postoperative pain after proximal femur surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Secretaria Estadual de Saúde - RJ	Secretaria Estadual de Saúde - RJ	https://ensaiosclinicos.gov.br/rg/RBR-3q6jfwp	<NULL>	Participants over 18 years of age; of both sexes; undergoing surgery to correct a fracture of the proximal end of the femur	Allergy or intolerance to any of the drugs used in the study; liver failure; estimated glomerular filtration rate &lt; 15 mL/min/1.73 m2; known or suspected coagulopathy; pre-existing neurological or anatomical deficits in the lower extremities; cognitive impairment with difficulties in assessing pain and severe psychiatric illness; chemical dependency; history of mental illness; hemoglobin less than 9 mg/dl; conversion of spinal anesthesia to general anesthesia; blood transfusion; duration of surgery longer than 3 hours; change of surgical plan or orthopedic complication during surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-73rpgs9	Neurofunctional Rehabilitation and tDCS in children with Rubinstein-Taybi Syndrome	Recruiting	Intervention	2025-01-14	<NULL>	<NULL>	7662	Neurofunctional Rehabilitation and Transcranial Direct Current Stimulation in children with Rubinstein-Taybi Syndrome	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-05	Irmandade da Santa Casa de Misericórdia de São Paulo	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-73rpgs9	<NULL>	Children with Rubinstein-Taybi Syndrome; no brain injuries; age between three and six years; degree of collaboration compatible with adequate performance in the activities proposed in this project; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Neurological or neuromuscular diseases associated with Rubinstein-Taybi Syndrome; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-3mj5vhs	Effects of resistance training with blood flow restriction on pain reduction, physical function improvement, and quality of life in patients with fibromyalgia	Not yet recruiting	Intervention	2025-01-13	<NULL>	<NULL>	7653	Effects of blood flow restriction strength training on clinical, functional markers, and quality of life in patients with fibromyalgia: a randomized, double-blind, sham-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Ciências da Saúde da Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-3mj5vhs	<NULL>	Individuals diagnosed with fibromyalgia by a rheumatologist according to the American College of Rheumatology criteria (2010); female; Aged between 20 and 59 years; not engaged in strength training for at least 6 months; physically active; absence of cardiovascular, neurological, or psychiatric disease; ankle-Brachial Index (ABI) between 0.90 and 1.40, not indicating peripheral arterial disease; score above 3 on the visual analog scale	Undergoing any concomitant treatment during the study protocol, such as engaging in physical exercise, changes in medication treatment, and complementary therapies; minimum attendance of 80% in the training program; worsening of disease symptoms during the experimental period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-4cpcf7q	Evaluation, development and effectiveness of a gentle eating intervention program	Recruitment completed	Intervention	2025-01-13	<NULL>	<NULL>	7654	Evaluation, development and effectiveness testing of an intervention program for Intuitive Eating: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4cpcf7q	<NULL>	Young Brazilian women; 18 to 30 years old; any color, race or ethnicity	Self-reported mental disorder(s); self-reported eating disorder(s); request to terminate your participation; expressly request that your data not be used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-6bcnbpq	Impact of the use of Flebon in the treatment of patients with Lipedema	Data analysis completed	Intervention	2025-01-10	<NULL>	<NULL>	7652	Impact of the use of Pycnogenol in the treatment of patients with Lipedema	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2024-02-23	B2 Medicos Associados	Farmoquimica	https://ensaiosclinicos.gov.br/rg/RBR-6bcnbpq	<NULL>	Women between 18-40 yeras old;with lipedema	Pregnant women;patients usig anorexigens;patients using anabolic medicines;patients on restrictive diets;patients with a proven adverse reaction to Pycnogenol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-9mg4sv7	Impact of a behavioral program to promote adherence to drug treatment by people with type 2 diabetes mellitus	Recruiting	Intervention	2025-01-09	<NULL>	<NULL>	7647	Effect of an Implementation of Intentions program to promote adherence to oral antidiabetics in people with type 2 Diabetes mellitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-11	Universidade Federal de São João Del Rei - Campus Centro Oeste Dona Lindu	Universidade Federal de São João Del Rei - Campus Centro Oeste Dona Lindu	https://ensaiosclinicos.gov.br/rg/RBR-9mg4sv7	<NULL>	Age 18 or over; both sexes; use of oral antidiabetics for at least six months; diagnosis of type 2 diabetes mellitus; positive intention (greater than or equal to 4) to carry out the behavior of taking oral antidiabetics; ability to read and write in Brazilian Portuguese; preserved cognitive state, assessed by means of a questionnaire containing seven pre-established questions	The medication is administered by a caregiver; they are using insulin to treat type 2 diabetes mellitus; they are being monitored for type 2 diabetes mellitus in a health service other than primary health care services	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-9f8qtqp	Effects of Posterior Crossbite Treatment in children with Aesthetic Aligners and Removable Appliances: a randomized clinical study	Not yet recruiting	Intervention	2025-01-09	<NULL>	<NULL>	7649	Effects of Posterior Crossbite Treatment in mixed dentition with Orthodontic Aligners and Conventional Appliances: a randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Universidade Anhaguera - UNIDERP	Universidade Anhaguera - UNIDERP	https://ensaiosclinicos.gov.br/rg/RBR-9f8qtqp	<NULL>	Patients in mixed dentition; 7 to 10 years old; both genders; with Angle Class I malocclusion; erupted permanent upper and lower incisors; and unilateral or bilateral posterior crossbite	Patients with craniofacial deformities; absence of permanent teeth; presence of anterior open bite; and previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-10zxwdrh	Moving the classroom: impacts on youth health, cognitive function, and academic performance	Recruiting	Intervention	2025-01-09	<NULL>	<NULL>	7650	Effectiveness of introducing physically active classes on children&apos;s cognitive function and academic performance: a cluster-randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-07	Departamento de Educação Física - Universidade Federal de Sergipe	Departamento de Educação Física - Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-10zxwdrh	<NULL>	Children aged between 7 and 9 years old; both sexes; without any restrictions preventing them from performing postural transitions; and who return the informed consent form properly signed by their parents or guardians	Students who stop attending school for any reason; students who express a desire to leave the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-7qgqqg2	How additional ingredients in coffee beverages affect glucose release in people	Recruiting	Intervention	2025-01-08	<NULL>	<NULL>	7646	Evaluation of the addition of ingredients in coffee beverages on the glycemic index and glycemic load in humans	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Faculdade de Saúde Pública da Universidade de São Paulo	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7qgqqg2	<NULL>	Aged between 18 and 50; both sexes; Body Mass Index (BMI) between 18.5 and 29.9 kg/m2 (eutrophic and overweight); consuming at least one cup of coffee a day in the last three months	Smoker; intolerance to consumption of coffee drinks on an empty stomach; allergy to the ingredients of the preparations; use of corticosteroids and hypoglycemic drugs at the time of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-5tqmbrx	Survival of Glass Ionomer or Resin Restorations in Fractured Molars Affected by Enamel Defect.	Recruiting	Intervention	2025-01-07	<NULL>	<NULL>	7641	Survival of GIC or RC Restorations in Molars Fractured by MIH - Randomized Clinical Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-15	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-5tqmbrx	<NULL>	As an inclusion criterion, individuals aged between 6 and 14 years who present at least one fully erupted first permanent molar with post-eruptive fracture due to MIH and loss of up to three surfaces, without compromising more than half of the occlusal impact area of the crown, will be selected. The selected teeth must not present pulp involvement (irreversible pulpitis and necrosis) or spontaneous pain. When there is doubt regarding the pulp diagnosis, additional exams such as periapical radiography and pulp vitality tests will be performed. If there is deep caries, only teeth that do not present a risk of pulp exposure on the interproximal radiograph will be included. Teeth with unsatisfactory restorations will also be included, and the operator will remove all previous restorations before the restorative protocol. Additionally, the patients must be available to attend follow-up appointments	The study will exclude teeth that only exhibit demarcated opacities due to MIH, teeth with enamel loss only due to MIH, teeth with orthodontic bands, patients whose parents do not consent to participation, age under 6 years or over 14 years, and teeth with more extensive structural loss than established by the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-7gwwxzg	Effect of infrared light on chronic renal patients undergoing hemodialysis and conservative treatment	Recruitment completed	Intervention	2025-01-07	<NULL>	<NULL>	7642	Effect of photobiomodulation with infrared led in chronic renal dialysis and non-dialysis patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Anhembi Morumbi	Hospital Regional do Baixo Amazonas Dr. Waldemar Penna	https://ensaiosclinicos.gov.br/rg/RBR-7gwwxzg	<NULL>	chronic kidney disease, male and female, age between 25 and 75 years, total number of patients 24	under 18 and over 80 years of age, debilitated, who do not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-9hyxs47	Impact of Surgery to Reduce Lung Size on the ability to breathe, the ability to exercise, and the quality of life of people with advanced Chronic Obstructive Pulmonary Disease (COPD)	Not yet recruiting	Observational	2025-01-07	<NULL>	<NULL>	7643	Impact of Lung Volume Reduction Surgery on lung function, exercise capacity and quality of life in patients with severe COPD	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-10	Disciplina de Cirurgia Torácica Escola Paulista de Medicina - Universidade Federal de São Paulo	Disciplina de Cirurgia Torácica Escola Paulista de Medicina - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9hyxs47	<NULL>	Patients of both genders; between 18 and 80 years of age; with severe chronic obstructive pulmonary disease (COPD) (exacerbating profile or not); clinically stable	Patients with bullous disease that has been removed by bullectomy; patients in a severe clinical condition; patients on mechanical ventilation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-10yj9xdv	Rehabilitation of shoulder dysfunctions using the Pilates method in patients with head and neck cancer undergoing neck dissection	Data analysis completed	Intervention	2025-01-07	<NULL>	<NULL>	7644	Rehabilitation of shoulder dysfunctions using the Pilates method in patients with head and neck cancer undergoing neck dissection with preservation of the accessory nerve: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-31	Fundação Cristiano Varella	Unifaminas	https://ensaiosclinicos.gov.br/rg/RBR-10yj9xdv	<NULL>	Patients of both sexes; over 18 years old; with a primary diagnosis of head and neck cancer; who underwent neck dissection with preservation of the accessory nerve; whether or not they have undergone radiotherapy and/or chemotherapy treatment; who have limited range of motion of the shoulder on the surgery side ranging from 50° to 149° for flexion and abduction movements; that are in the acute phase, that is, evaluated within a maximum period of up to 45 days from the date of surgery	Patients undergoing neck dissection where there is a need to perform complete resection of the accessory nerve; who have had previous surgery and/or radiotherapy for head and neck cancer; with shoulder dysfunction already established before the surgical procedure; who have received any physiotherapeutic care with the aim of restoring range of movement; who have a range of motion limited to less than or equal to 49° for shoulder flexion and abduction movements or greater than 149°; who have cognitive impairment or any other impairment that prevents them from performing and understanding the proposed exercises; who underwent bilateral surgery and as a result have a range of movement for flexion and abduction of less than 150° in both upper limbs; those who refused to participate in the study; those who refused to sign the Free and Informed Consent Form after being informed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-10cwcpzj	Effect of nitrate on circulation and muscular endurance in humans	Recruiting	Intervention	2025-01-07	<NULL>	<NULL>	7645	Effect of inorganic nitrate on microvascular function, angiogenesis and muscle endurance in healthy humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-10cwcpzj	<NULL>	Healthy adults; of both sexes; with a minimum age of 18 years and a maximum age of 40 years; non pregnant; people who are available to participate in all visits to carry out the study; people from other cities who are available to be in the city where the experiments will be carried out	Individuals with cardiovascular diseases; pulmonary diseases; diabetes mellitus; hypertension; dyslipidemia; smoking; urinary tract infection; breastfeeding women; people who use drugs that interfere with amino acid metabolism and NO production; presence of osteomyoarticular injuries; use of nutritional and pharmacological ergogenic aids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-54wxgxv	The effect of a new program to improve the general and oral health of students at a municipal school in Bauru, São Paulo, Brazil	Data analysis completed	Intervention	2025-01-06	<NULL>	<NULL>	7636	Effectiveness of a new program to improve the general and oral health of schoolchildren in Bauru, São Paulo, Brazil	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-54wxgxv	<NULL>	Schoolchildren aged 6-9 years; feminine and masculine gender; children with cooperative behavior and in good physical and medical health; children who presented a signed consent form; the presence of first permanent molars without gingival tissue covering all the occlusal surface; and permanent first molars that present an occlusal surface of pits and fissures with a carious lesion in the enamel or with a high-caries-risk (presence of a tooth with a carious lesion, lost or restored, which is not a developmental defect of the enamel)	Children with orthodontic braces; paranormal occlusion; severe bruxism; allergy to resinous materials or any other material used in the study; and poor behavior	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-3nvq79h	Effects of Guarana on physical performance: a clinical study on anaerobic fitness	Data analysis completed	Intervention	2025-01-06	<NULL>	<NULL>	7637	Effects of Guarana (Paullinia cupana) supplementation on Heart Rate Variability and Anaerobic Fitness: a randomized, crossover, placebo-controlled, triple-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-3nvq79h	<NULL>	Healthy and physically active men; age between 18 and 30 years; non-smokers; no history of cardiovascular or musculoskeletal diseases; not using any medication or ergogenic substances	Individuals who do not meet the inclusion criteria; are unable to perform the jump protocol or withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-46p3q6b	Effects of Combined Cycling and Weight Training on the response to treatment of patients with Bowel Cancer that has spread to other organs: contribution of substances released by the muscle	Recruiting	Intervention	2025-01-06	<NULL>	<NULL>	7638	Effects of Combined Aerobic and Resistance Training on the response to chemotherapy in patients with Metastatic Colorectal Cancer: contribution of microRNAs	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Escola de Educação Física e Esporte da Universidade de São Paulo	Conjunto Hospitalar de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-46p3q6b	<NULL>	Patients aged 18 years or older; recent diagnosis of stage IV colorectal cancer, with measurable lesion and available and proven biopsy; candidates for chemotherapy sessions; Performance Status Scale (Eastern Cooperative Oncology Group - ECOG) between 0 and 2	Presence of unstable (uncontrolled) comorbidity; presence of dementia (score &lt;23 on the Mini Mental State Examination); having participated in a physical training program in the last 6 months; having active infections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-107m2sgt	10 years of nutritional health records from the teaching clinics of the Brazilian Institute of Rehabilitation Medicine, Rio de Janeiro	Not yet recruiting	Observational	2025-01-06	<NULL>	<NULL>	7639	Retrospective analysis of 10 years of nutritional records in the teaching clinics of the IBMR University Center, Rio de Janeiro	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-03-10	Instituto Brasileiro de Medicina de Reabilitação	Instituto Brasileiro de Medicina de Reabilitação	https://ensaiosclinicos.gov.br/rg/RBR-107m2sgt	<NULL>	Medical records of patients treated at the Teaching Clinics of the Brazilian Institute of Medicine and Rehabilitation (IBMR) University Center in Rio de Janeiro during the period from January 2014 to December 2024. Records must contain complete and up-to-date information on diagnoses, treatments, and clinical progress, with detailed documentation of nutrition-related health conditions, specifically hypertension, diabetes, obesity, malnutrition, and eating disorders. Records of patients treated at all units of the Teaching Clinics, regardless of gender, age, or ethnicity, provided they meet the other established criteria	Medical records with incomplete or illegible information, hindering the extraction and analysis of the data necessary for the research. Records of patients whose care occurred outside the period of interest, that is, before January 2014 or after December 2024. Records related to emergency or specific care that do not allow for a comprehensive analysis of nutrition-related health conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-10h76xvp	What are the differences in complications between two techniques for performing Tracheostomy - the Percutaneous technique and the Open technique?	Recruiting	Observational	2025-01-06	<NULL>	<NULL>	7640	Is there a difference between complications of Percutaneous versus Open Tracheostomy?	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-01	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10h76xvp	<NULL>	Patients undergoing tracheostomy; aged 18 years or older; both sexes	Emergency surgery; previous tracheostomy; blood clotting disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-78zfpxd	Comparative study between Local Freezing and back injection for Pain control after thoracic surgery	Not yet recruiting	Intervention	2025-01-03	<NULL>	<NULL>	7634	Cryoanalgesia versus thoracic epidural analgesia for Pain control in the postoperative period of thoracic surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78zfpxd	<NULL>	Patients of either gender; 18 years of age or older; undergoing invasive thoracic procedures, whether thoracotomy, sternotomy, or videothoracoscopy	Patients undergoing sympathectomy; patients undergoing procedures that do not access the pleural cavity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2tr8m36	Effects of organizing a Program to Detect and Monitor Lung Nodules in people at high risk of Lung Cancer	Recruiting	Observational	2025-01-03	<NULL>	<NULL>	7635	Impacts of structuring a Lung Nodule Detection and Monitoring Program in a population at high risk for Lung Cancer	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2tr8m36	<NULL>	Individuals between the ages of 50 and 80; of either gender; current or former smokers for a maximum of 15 years; smoking history of 20 pack-years or more	Individuals who are unable to undergo the tomographic scan; individuals who present with symptoms highly suggestive of lung cancer as hemoptysis, chest pain, change in cough pattern, unintentional weight loss greater than 10 kg; diagnosis of severe lung or heart disease, use of multiple medications and/or need for home oxygen therapy; history of radiation therapy to the chest region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-8w7d8np	The impact of math tasks on volleyball players&apos; performance: a randomized crossover study	Data analysis completed	Intervention	2025-01-02	<NULL>	<NULL>	7626	Effect of Math-related cognitive activities on Volleyball performance: a randomized crossover study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8w7d8np	<NULL>	Train volleyball for at least two years; compete at the school level; be between 12 and 17 years old; female	Withdraw from the research; absence on one of the data collection days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-55gksmb	The effect of mental fatigue on cognitive and physical aspects in young athletes and non-athletes	Data analysis completed	Intervention	2025-01-02	<NULL>	<NULL>	7627	The effect of mental fatigue on cognitive and physical aspects in young athletes and non-athletes	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-02-27	Departamento de Educação Física - Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-55gksmb	<NULL>	The inclusion criteria that will be adopted are: 1) to practice a systematized team sport at least twice a week with a previous history of at least 6 months; 2) to be male; 3) to be between the ages of 13 and 16; 4) to present the free and informed consent form (TCLE) and the free and informed assent form (TALE); 5) to have no physical limitations that would prevent the physical test from being carried out and no cognitive limitations that would prevent the psychological tests from being carried out cleanly.	The inclusion criteria that will be adopted are: 1) to practice a systematized team sport at least twice a week with a previous history of at least 6 months; 2) to be male; 3) to be between the ages of 13 and 16; 4) to present the free and informed consent form (TCLE) and the free and informed assent form (TALE); 5) to have no physical limitations that would prevent the physical test from being carried out and no cognitive limitations that would prevent the psychological tests from being carried out cleanly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-9g3xrqk	Testing ways to make patients&apos; experience more comfortable after chest surgery	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7628	Measures to improve the experience of patients undergoing thoracic surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9g3xrqk	<NULL>	Patients aged 18 years or over; both genders; undergoing invasive thoracic procedures whether by thoracotomy, sternotomy or videothoracoscopy	Patients under 18 years of age; patients who do not sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-7z76spy	Pilates method and virtual games: strategies to improve the quality of life of women with breast cancer treated by the SUS – randomized study	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7629	Pilates Method and Augmented Reality: strategies to improve the quality of life of users of the public health system diagnosed with Breast Cancer – randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7z76spy	<NULL>	Women; over 18 years old; SUS users; diagnosed with breast cancer undergoing treatment at the Advanced Center for Breast Diagnosis at Hospital das Clínicas de Goiânia	Clinical, orthopedic or neurological contraindications that prevent the practice of physical activity; less than 85% of the expected frequency of activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2rzx848	The Effects of Adding Pelvic Floor Muscle Exercises to Behavioral Therapy Associated with Transcutaneous Parasacral Nerve Electrical Stimulation on Sleep Quality in Women Who Are Awakened by Their Bladder to Urinate: A Randomized Controlled Clinical Trial	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7630	The effects of adding Pelvic Floor Muscle Training to Behavioral Therapy associated with Transcutaneous Parasacral Nerve Electrostimulation on Sleep Quality in women with Nocturia: a randomized, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Faculdade de Educação Física e Fisiotrapia	Faculdade de Educação Física e Fisiotrapia	https://ensaiosclinicos.gov.br/rg/RBR-2rzx848	<NULL>	Women over 18 years of age; women with complaints of nocturia (being woken up by the bladder at least once a night, every night for the last 30 days); having Overactive Bladder Syndrome (OBS) who obtain a score ≥ 8 on the Overactive Bladder – Validated 8 (OAB-V8) questionnaire - an instrument for assessing overactive bladder and scoring very or very high on question 6 in the same questionnaire and who have a high risk of sleep apnea; the research participant must have had sexual intercourse for the pelvic muscle assessment to be carried out	Not knowing how to read and not being able to answer the questionnaires; having a urinary tract infection in the last two weeks; smoking; having undergone previous pelvic surgery with the exception of a cesarean section; having undergone previous pelvic radiotherapy; having a neurological disease; not undergoing pharmacological and physiotherapeutic treatment for Overactive Bladder Syndrome (OBS); having only Stress Urinary Incontinence (SUI); pelvic floor muscle strength 0 and 1 on the modified Oxford scale; being pregnant and up to 3 months postpartum; using medications that may affect nocturnal urination (antimuscarinics, diuretics); uncontrolled type 2 diabetes and heart disease; uncontrolled high blood pressure; low risk of sleep apnea; night and shift workers; not accepting to participate in the research and/or not signing the free and informed consent form (FICF)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-99xqr4t	Effects of ear Acupuncture on the Mental Health of nursing professionals in a cancer hospital	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7631	Effects of Chinese Auricular Acupuncture on Compassion Fatigue and Emotional Health of nursing professionals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-16	Hospital Universitário Júlio Müller	Secretaria do Estado de Saúde de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-99xqr4t	<NULL>	nursing professionals; of both sexes; aged 18 or over; with at least 6 months of practical experience; who work in sectors that provide direct patient care; who have answered all the questions in the questionnaires; who have time available to participate in the research stages; and who agree to participate in the research by signing the free and informed consent form	having a previously diagnosed severe psychiatric disorder and currently using psychotropic medications at the time of data collection; being pregnant; working exclusively in administrative functions (unit management and nursing coordination); using a hearing aid; presenting dermatological lesions; infection; inflammation; or injury in the auricular pavilion; or being allergic to adhesive tape on the auricle; or excessive oiliness in the ear	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2kms8f9	Sleep disorders and their causes in children and adolescents in a city in northeastern Brazil	Not yet recruiting	Intervention	2025-01-02	<NULL>	<NULL>	7632	Sleep disorders and associated factors in children and adolescents in the metropolitan region of Recife	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2kms8f9	<NULL>	presence of headache for 3 months or more, of any origin and with intensity ≥ four on the Numeric Pain Intensity Scale.	presence of infection, inflammation or injury to the pinna; microporous tape allergy; prior energy therapy up to 3 months prior to the intervention; those undergoing physiotherapeutic treatment or making continuous use of medication for pain relief and pregnant women. In addition, it will be considered as a loss: refusal to receive auricular treatment, unavailability of time for TA sessions; missing two consecutive sessions and not showing up on the days scheduled for the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-10rr7kbx	Study between two surgical techniques for the treatment of Stress Urinary Incontinence, 5-year follow-up	Recruitment completed	Observational	2024-12-27	<NULL>	<NULL>	7624	Clinical study between Retropubic and Transobturator Slings for the treatment of Stress Urinary Incontinence: 5-year follow-up	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-01	Centro Universitário Saúde ABC - Faculdade de Medicina do ABC	Centro Universitário Saúde ABC - Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-10rr7kbx	<NULL>	Female patients. Age over 18 years old. Absence of associated neurological diseases. Patients previously submitted to surgical treatment to correct urinary incontinence, either by Retropubic Sling or Transobturator Safyre VS® and Safyre T-Plus®. Patients who agree to attend to undergo the proposed procedures	Pregnancy. Acute urinary tract infection.Sequelae of high exposure to ionizing radiation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-7z4qkcj	Treatment with manual therapy technique for pain relief in patients with Endometriosis	Recruitment completed	Intervention	2024-12-23	<NULL>	<NULL>	7623	Effect and mechanism of the manual Microphysiotherapy technique action associated with the Biological Laws methodology in the treatment of Endometriosis: a controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-08	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7z4qkcj	<NULL>	Women; who have a medical diagnosis of endometriosis; in the age group from 18 years to 45 years; without distinction of color/race or ethnicity; who live in the cities of Pato Branco-PR or Palhoça-SC and/or nearby cities; who agree to participate in all stages of the research, signing the Informed Consent Form (ICO)	Women who have other acute or chronic inflammatory pathologies; who are continuously using anti-inflammatories or analgesics; women who have previously undergone laparoscopic surgery or other surgeries for endometriosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-8w8rxbb	Assessment of Primary and Accumulated Dermal Irritability and Sensitivity of a cosmetic product	Not yet recruiting	Intervention	2024-12-21	<NULL>	<NULL>	7622	Assessment of Primary, Accumulated Dermal Irritability and Sensitization of a facial moisturizer, through patch testing (Patch Test)	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-21	IPCLIN - Instituto de Pesquisa Clínica Integrada Ltda	IPCLIN - Instituto de Pesquisa Clínica Integrada Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8w8rxbb	<NULL>	Full skin on the back;age from 18 to 59 years old;male and female;participants with phototypes I, II, III and IV according to the Fitzpatrick classification;absence of history of irritation and allergy to the material used in the study;have signed the free and informed consent form;participants who wish to participate in the study without financial profit	Participants who refuse to participate in the study in question;skin marks in the experimental area that interfere with the assessment of possible skin reactions,such as scars,increased hairiness,large quantities of ephelides and nevus and sunburn;active dermatoses that could interfere with the study results;pregnant or breastfeeding women;history of allergic reactions,irritation or intense sensations of discomfort to topical products such as cosmetics and medicines;volunteers with a history of allergy to the material used in the study;history of atopy;history of pathologies aggravated or triggered by ultraviolet radiation;intense sun exposure or tanning session up to 15 days before the initial assessment;expected intense sun exposure or tanning session during the study period;plan to take a swim in the sea, swimming pool or sauna during the study;participants who practice water sports;use of the following systemic topical medications:immunosuppressants,antihistamines,non-steroidal anti-inflammatory drugs,and corticosteroids up to two weeks before the selection;treatment with acid vitamin A and/or its derivatives orally or topically up to 1 month before the start of the study;anticipation of vaccination during the study or up to 3 weeks before the study,so as not to correlate the possible side effects of the vaccine with the study in question;any condition not mentioned above that,in the opinion of the investigator,may compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-9jw6tnm	Study of two different devices for bone augmentation	Not yet recruiting	Intervention	2024-12-20	<NULL>	<NULL>	7615	Barbell technique versus titanium reinforced PTFE membranes for bidirectional bone augmentation: multi-centre randomized clinical trial study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	https://ensaiosclinicos.gov.br/rg/RBR-9jw6tnm	<NULL>	Patients should have 18 years or older; signed inform consent; partial edentulism (up to 4 adjacent missing teeth); atrophied alveolar ridge with one or more adjacent missing teeth; atrophied alveolar ridge with residual remaining thickness less than 4mm; sufficient bone height at the surgical site to install implant	Patients with periodontal or peri-implant diseases; general contraindications for surgical procedures; inflammatory process / disease of oral cavity; dental implants adjacent to the surgical site; known or suspected non-compliance, drug or alcohol abuse; smokers or subjects who did not quit smoking at least 3 months before the surgery; diabetes; previous, concurrent or planned radiation therapy for head or neck cancer; concurrent or previous immunosuppressant, bisphosphonate, high-dose or long-term corticosteroid therapy; pregnant or lactating women; women of childbearing age, who are not using a highly effective method of birth control; participants in an investigational device, drug or biological study within the last 26 weeks prior to study start; participants in any other clinical investigation during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2cw89yf	Influence of the Dentin Drying Method on the adhesive interface – clinical and laboratory evaluation	Recruiting	Intervention	2024-12-20	<NULL>	<NULL>	7616	Effect of Moisture Control in dentin on the tooth/restoration interface – an in vivo and in vitro study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Federal do Mato Grosso do Sul	Universidade Federal do Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2cw89yf	<NULL>	Volunteer aged 18 or over; both genders; present good oral health conditions, without severe or chronic periodontal disease; presence of at least two third molars with indicated extraction	Presence of acute pain related to third molars; continuous use of analgesics and anti-inflammatories; history of known allergy to the restorative materials to be used; difficulty accessing third molars due to anatomical or surgical factors; presence of temporomandibular disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2qppkbb	Effects of pressure with fingers on points bp6 and ig4 of chinese medicine on pain in pregnant women in a maternity hospital in southern Bahia	Recruitment completed	Intervention	2024-12-20	<NULL>	<NULL>	7617	Effects of acupressure on points bp6 and ig4 on pain in pregnant women at a maternity hospital in southern Bahia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-04-01	Universidade Estadual de Santa Cruz	Hospital Materno Infantil  Dr. Joaquim Sampaio	https://ensaiosclinicos.gov.br/rg/RBR-2qppkbb	<NULL>	Pregnant women over 18 years of age; gestational age from 37 weeks; spontaneous, induced and/or supervised labor; with effective contractions and dilation greater than or equal to 4 cm; with a live fetus, in vertex cephalic presentation and in good vitality conditions; present intact skin bilaterally at the bp6 and ig4 points of traditional Chinese medicine	"Pregnant women who tested positive for COVID-19 less than 14 days ago; presence of obstetric complications or complications such as placenta previa, pre-eclampsia, ruptured membranes, amniotic fluid index 5 cm; dilation greater than 8 cm; immediate indication for cesarean section; 
knowledge of or having used pressure therapy with fingers or needles such as acupuncture, acupressure, doin, shiatsu or reflexology"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:13
RBR-4x9pk3m	Clinical study of Toothpaste with bioactives from the sap of the Amazonian dragon&apos;s blood tree (Croton lechleri) and Activated charcoal: sensory properties and effects on Bacterial plaque and Gingival health	Recruitment completed	Intervention	2024-12-20	<NULL>	<NULL>	7618	Clinical study of Toothpaste with Dragon´s blood (Croton lechleri) and Actived charcoal: organoleptic properties and effects on Dental biofilm and Gingival health	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-04-03	Universidade Estadual Vale do Acaraú	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4x9pk3m	<NULL>	Spontaneous demand; screening between April 2023 and April 2024; adults between 18 and 40 years old; both sexes; all ethnicities; without compromising systemic health; no smoking or alcohol consumption; dentition with more than 24 teeth; no ongoing orthodontic treatment; no daily use of mouthwashes; no use of mouthwashes and/or toothpastes with chlorhexidine in the last 60 days	Failure to sign the informed consent form (ICF); dropping out of the study; inappropriate use of the products to be tested; motor incoordination that makes tooth brushing difficult; surgery on the face or mouth that makes tooth brushing difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2y7jf2c	Efiicacy of at-home teeth bleaching comparing bleaching brush vs. tray-delivery  6% hydrogen peroxide	Not yet recruiting	Intervention	2024-12-20	<NULL>	<NULL>	7619	Efiicacy of brush-on vs. tray-delivery at-home bleaching with 6% hydrogen peroxide: A randomized, single-blind, split-mouth controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2y7jf2c	<NULL>	Patients should be 18 years or older; to be female;masculine;patients need to have a good general and oral health status;absence of caries lesions;restorations and endodontic treatment in the antero-inferior teeth;the lower canines should be color A2 or darker according to the value-oriented Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany)	Patients already submitted to dental bleaching;undergoing orthodontic treatment;with severe discoloration due to tetracycline stains;fluorosis will not be included in the study;in addition;participants with any other pathology that may cause sensitivity;such as recession;dentin exposure;presence of visible cracks in the teeth;or history of hypersensitivity will also be excluded;additionally pregnant;lactating women;patients with dental bruxism;taking analgesic;anti-inflammatory drugs will not be included in the study sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-7bmw7t2	Aromatics for controlling dental anxiety in children: a clinical study	Recruitment completed	Intervention	2024-12-20	<NULL>	<NULL>	7621	Aromatherapy in the management of dental anxiety in pediatric dental patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-7bmw7t2	<NULL>	Parents and/or guardians authorize the child to participate in the research. Children who score between 5 and 8 on the modified Venham Pictures Test scale. Children without health impairment. Children with the intellectual capacity to answer questions. Patients between 6 and 12 years of age. Both genders	Children with allergies. Children with cognitive difficulties. Children with systemic impairments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2n9x58k	A randomized, controlled study on the use of antifoaming and mucolytic agents in preparation for upper digestive endoscopy	Terminated	Intervention	2024-12-19	<NULL>	<NULL>	7610	Use of mucolytics and antifoams in preparation for Upper Digestive Endoscopy diagnosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Instituto Hospital de Base do Distrito Federal	Instituto de Gestão Estratégica de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-2n9x58k	<NULL>	Outpatient care for diagnostic upper gastrointestinal endoscopy; age greater than or equal to 18 years; both sexes	Patients who did not sign the Informed Consent Form; those who had forms filled out incompletely; patients with malignant gastrointestinal tract diseases; and neurological diseases; with an indication of therapeutic procedures at the time of the examination; the presence of food residues in the esophagus or stomach	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-5g3ckf5	Evaluation of the performance of Removable partial dentures in polymers	Recruiting	Intervention	2024-12-19	<NULL>	<NULL>	7611	Clinical, functional, and mechanical performance of Polyether-ether-ketone (PEEK) frameworks for Removable partial dentures	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-23	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas – Unicamp	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas – Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-5g3ckf5	<NULL>	Adult patients, over 18 years of age; both sexes; patients who require rehabilitation with conventional maxillary total dentures and mandibular kennedy class I removable partial dentures	Patients who present signs or symptoms of temporomandibular disorder; parafunctional habits; severe periodontitis; physical or cognitive limitations that prevent assessments and regular oral hygiene from being carried out; uncontrolled systemic diseases that prevent the completion of some stage of treatment; the impossibility of attending pre-determined appointments for evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-9mj5ymr	How pre- and post-Bariatric Surgery Exercise impacts patients&apos; health	Suspended	Intervention	2024-12-19	<NULL>	<NULL>	7612	Effects of Physical Exercise pre and post surgery on health outcomes of Metabolic and Bariatric Surgery patients	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade de Pernambuco	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-9mj5ymr	<NULL>	Individuals of both sexes; age between 18 and 60 years; no contraindications to supervised physical exercise; enrolled in the bariatric and metabolic surgery program at Hospital das Clínicas da Universidade Federal de Pernambuco (HC-UFPE/EBSERH)	Individuals with severe psychiatric impairments such as schizophrenia, personality disorders, uncontrolled depression, or suicidal tendencies; neurological disorders that may interfere with assessments or interventions; uncontrolled addiction to alcohol or other drugs; presence of active inflammation or chronic infectious diseases; osteoarticular disorders that prevent the performance of physical exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-7dqtrgh	Galvanic Vestibular Stimulation and Sensory Integration Therapy in children with Autism Spectrum Disorder	Recruiting	Intervention	2024-12-19	<NULL>	<NULL>	7613	Galvanic Vestibular Stimulation and Sensory Integration Therapy in children with Autism Spectrum Disorder: a randomized, placebo-controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-09	Universidade Evangélica de Goiás	Follow Kids - Clinica de Neuro Reabilitação Infantil	https://ensaiosclinicos.gov.br/rg/RBR-7dqtrgh	<NULL>	Diagnosis of autism spectrum disorder confirmed through clinical examination; have a standardized neurobehavioral assessment that confirms and categorizes the severity of autism spectrum disorder; children levels I, II and III according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V); age between five and nine years of age of both sexes; children who demonstrate sufficient response to understand simple verbal commands; no medication changes at least six months before the start of the study and during its execution; statement of informed consent signed by a legal guardian; statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2skg8p4	Effects of bodyweight physical training on the physical and mental health of military police officers from the special actions battalion	Not yet recruiting	Intervention	2024-12-19	<NULL>	<NULL>	7614	Effects of a bodyweight Physical Training protocol on the physical and mental health of military police officers from the special actions battalion	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2skg8p4	<NULL>	Military police officers from the 2nd Special Actions Battalion of the Military Police - BAEP de Santos; who agree to participate in the study; have worked in the military police for at least 1 year; do not have a previous psychiatric diagnosis; age between 26 and 50 years; male	Military police officers who use medicines that modulate the nervous system; and/or who present an attendance rate of less than 75% in the physical training sessions proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-3bhzqsm	Clinical trial to evaluate superior efficacy and safety of the association of Diltiazem hydrochloride 2% + Lidocaine hydrochloride 2% perianal gel in relation to Proctyl® rectal ointment (Policresulene 50 mg/g + Cinchocaine hydrochloride 10 mg/g) in the treatment of chronic Perianal Fissure	Not yet recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7603	"DLG Protocol: Phase III, multicentre, single-blind, parallel, randomized clinical trial to evaluate the
superior efficacy and safety of the fixed-dose combination of diltiazem hydrochloride 2%
+ lidocaine hydrochloride 2% perianal gel compared to Proctyl® rectal ointment
(polyresulene 50 mg/g + cinchocaine hydrochloride 10 mg/g) in the treatment of chronic
perianal fissure"	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2024-12-20	Irmandade da Santa Casa de Misericórdia de Santos	Laboratórios Ferring LTDA.	https://ensaiosclinicos.gov.br/rg/RBR-3bhzqsm	<NULL>	Participants capable of reading, or following along with the reading, understanding, and signing the informed consent form approved by the research ethics committee system; of both sexes; aged 18 years or older; capable of adequately communicating with the investigator and the clinical study team; diagnosed with chronic anal fissure; female participants without the potential to become pregnant; agree to use a safe contraceptive method; agree not to have anal intercourse during the study period	Participants diagnosed with malignant disease in the last 5 years, except for successfully treated basal cell carcinoma; those with chronic diseases on regular medication that, at the investigator’s discretion, may interfere with the clinical study; participants who show hypersensitivity or contraindication to any of the components of the formulations; female participants who are breastfeeding, planning to become pregnant, or who test positive for pregnancy during the study period; any clinical observation (clinical/physical evaluation) that is interpreted by the investigator as a risk to participation in the clinical study; participants who refuse to undergo visual or medical examination of the anal fissure; participants with more than one anal fissure; participants with anal fissure associated with or caused by other conditions, including but not limited to: drug-induced, trauma, human immunodeficiency virus (HIV) infection, anal fistula, inflammatory bowel disease, perianal sepsis, or malignancy; participants who refuse to discontinue all other concomitant topical preparations applied in and around the anus from the day before the start until the end of the clinical study; use of sitz baths from the signing of the informed consent form (ICF) until the end of the clinical study; use of anesthetics from the signing of the ICF until the end of the clinical study; injection of botulinum toxin into the anal fissure within 3 months prior to signing the ICF; participants actively treated with antiviral therapies for HIV (e.g., indinavir, nelfinavir, ritonavir); participants treated with any prohibited medication within 14 days prior to signing the ICF such as: cytochrome P450 (CYP450) inhibitors and inducers; cytochrome P3A4 (CYP3A4) substrates, inhibitors, and inducers; benzodiazepines; β-adrenoceptor antagonists (Beta-Blockers); calcium channel blockers; digoxin; opioids; participants with any of the following concomitant conditions: sick sinus syndrome, except in the presence of a functioning ventricular pacemaker; second or third-degree atrioventricular block, except in the presence of a functioning ventricular pacemaker; hypotension (systolic pressure less than 90 mmHg); history of reduced left ventricular function, bradycardia, first-degree atrioventricular block, or prolonged PR interval (&gt; 0.2 seconds / &gt; 200 milliseconds) on electrocardiogram; documented acute myocardial infarction and pulmonary congestion by radiography; history of active uncontrolled diabetes and/or hypertension; current infection treated with a macrolide antibiotic; clinical evidence or history of fecal incontinence; clinical evidence or history of chronic constipation or constipation in the 4 weeks prior to signing the ICF (defined as 2 or fewer bowel movements per week; associated with straining/passage of hard stools); clinical evidence or history of anal fistula; clinical evidence or history of anal abscess; clinical evidence or history of fixed anal fibrosis; history of inflammatory bowel disease or active gastrointestinal disorders (e.g., inflammatory bowel disease, Crohn’s disease, ulcerative colitis); history of any previous anal or rectal surgery, including but not limited to: lateral sphincterotomy and anal dilation or other previous surgery involving the anal canal or perianal region; history of pelvic radiotherapy; participants with associated acute hemorrhoidal crises; participants with anal or perianal cancer; participants with a history of cardiac (any), renal (resection or renal agenesis), gastrointestinal (partial or total removal of the esophagus, stomach, duodenum, jejunum, ileum, ascending colon, transverse colon, descending colon, sigmoid colon, or rectum) and liver or pancreas surgery, as well as a history of transplantation; having any planned surgery that may interfere with the successful completion of the clinical study; participants who have received therapy with diltiazem hydrochloride gel or other topical calcium channel blockers or other topical medicinal ointments, which at the physician’s discretion may interfere with the outcome of the clinical study, 3 days before signing the ICF; participants using oral calcium channel blockers, nitrates (e.g., glyceryl trinitrate GTN), or any other vasodilators; any clinically significant condition of renal, hepatic, neurological, dermatological, immunological, psychiatric (including drug or alcohol users) or hematological disease or any clinically significant abnormal laboratory findings that, at the investigator’s discretion and from medical records, may compromise participation in the clinical study; presenting a positive preliminary drug test result for amphetamine/methamphetamine, opiate/morphine, marijuana/tetrahydrocannabinol, cocaine/benzoylecgonine, and/or benzodiazepine; research participants who have participated in clinical study protocols in the last 12 months (National Health Council Resolution CNS 251, August 7, 1997, item III, subitem J), unless there may be direct benefit to the research participant, at the investigator’s discretion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-9vf9x3w	Effects of Osteopathic Manual Therapy (OMT) on the Stress levels of workers in a hospital environment	Not yet recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7604	Effects of Osteopathic Treatment on Stress levels of workers in a hospital environment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-9vf9x3w	<NULL>	64 nurses and nursing technicians will be included; of both sexes; aged between 20 and 65 years old; all workers at the Polyclinic Hospital in the city of Cascavel/PR with at least six months of experience	All employees who are undergoing treatment with psychiatric medications will be excluded from this survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-2j9zqkz	Teledentistry vs. Traditional Care: Monitoring Oral Health in Homebound Older Adults in Primary Care	Not yet recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7605	Oral Health Monitoring of Homebound Older Adults Using Teledentistry Versus Traditional Strategy by Oral Health Teams in Primary Care: A Pragmatic Randomized Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2j9zqkz	<NULL>	Both genders. Dentists: Must have an effective bond with the public health service, be hired through a selection process or linked to a multiprofessional residency program, have access to the internet via mobile device or computer with multimedia capabilities, and demonstrate availability to participate in the study, as well as a commitment to performing the proposed activities within the designated timeframe. Older Adults: Aged 60 or older, home-dwelling, monitored by oral health teams from the Family Health Strategy, with access to the internet (preferably via mobile device), and able to comprehend and respond to the proposed questions. For those older adults unable to comprehend and/or respond to the research questions, their caregivers (aged 18 or older) will be included. Caregivers of Older Adults: Whether laypersons or professionals, aged 18 or older, caring for older adults aged 60 or older, either home-dwelling or not, monitored by oral health teams from the Family Health Strategy, with access to the internet and able to comprehend and respond to the proposed questions	Dentists: Those on vacation, sick leave, leave of absence, retirement process, under administrative investigation, or members of inactive teams during the intervention phase of the research. Older Adults: Those who are out of their home at the time of data collection for any reason; those not receiving home visits; residents of Long-Term Care Facilities for the Elderly (ILPI); or those with caregivers younger than 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-9xjt5fp	Facilitation of neurofunctional training with tDCS and rTMS in children with ASD	Recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7606	Facilitation of Neurofunctional Training with tDCS and rTMS on the left dorsolateral prefrontal cortex in children with Autism Spectrum Disorder: a randomized, placebo-controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-03	Associação Educativa Evangélica	Clinica de Neuroreabilitação Infantil Follow Kids	https://ensaiosclinicos.gov.br/rg/RBR-9xjt5fp	<NULL>	Diagnosis of autism spectrum disorder confirmed through clinical examination; have a standardized neurobehavioral assessment that confirms and categorizes the severity of autism spectrum disorder; children levels I, II and III according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V); age between three and eight years of age; children who demonstrate sufficient response to understand simple verbal commands; no medication changes at least six months before the start of the study and during its execution; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-66sfk5k	Diastáse em Mulheres	Recruitment completed	Intervention	2024-12-18	<NULL>	<NULL>	7607	Diastasis of the abdominal muscles in women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-10	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-66sfk5k	<NULL>	Women aged 18 or over; were pregnant; with diastasis from 2 cm; no previous abdominal aesthetic surgeries; no musculoskeletal disease	Pregnant women; Women diagnosed with a hernia in the midline of the abdomen; Obese	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-8hvdh5r	On-line educational strategy to reducing night awakenings and prolonging sleep in the mother- baby dyad: Randomized Clinical Trial	Recruitment completed	Intervention	2024-12-18	<NULL>	<NULL>	7608	On-line educational strategy to reducing night awakenings and prolonging sleep in the mother- baby dyad: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-15	Departamento de Enfermagem da Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-8hvdh5r	<NULL>	Mothers aged 18 or over; babies aged 10 months and over and under 25 months; who have three or more nocturnal awakenings per night; mothers with internet access and who have installed the Whatsapp® and Google Meet® applications on their smartphone or notebook	Mothers diagnosed with a mental disorder; babies born prematurely (less than or equal to 35 weeks and 7 days); babies with low weight for age; infants with a physician&apos;s diagnosis of neurological or psychiatric impairment; infants diagnosed with gastroesophageal reflux	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-5v6bkky	Vegetable gardening at the Primary Health Care Unit	Recruiting	Intervention	2024-12-18	<NULL>	<NULL>	7609	Horticulture therapy in health promotion in the Primary Health Care: an exploratory study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de São Paulo	Secretaria Municipal de Saúde de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5v6bkky	<NULL>	Healthy volunteer; both gender; more than 18 years old; overweight; diabetes mellitus; systemic arterial hypertension; dyslipidemia;	Mental deficiency; confusion; pregnant; nursing mother	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-7dmytc7	Effect of Propolis on Vascular and Muscular Health	Recruiting	Intervention	2024-12-17	<NULL>	<NULL>	7599	Effect of Supplementation with Green Propolis Extract on Vascular Health and Muscular Recovery in Humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-7dmytc7	<NULL>	Healthy adults and older adults; both sexes; minimum of three months of prior resistance training experience	Cardiovascular diseases; pulmonary; diabetes mellitus; hypertension; dyslipidemia; smoking; pregnant women; lactating women; use of drugs that interfere with NO production (synthetic estrogen, angiotensin-converting enzyme inhibitors); presence of osteoarticular lesions and use of supplements (creatine, caffeine, antioxidant vitamins, minerals); anabolic steroids or anti-inflammatory drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-9s3dcs4	Photobiomodulation on Diabetic Foot	Recruiting	Intervention	2024-12-17	<NULL>	<NULL>	7600	Analysis of physiological effects, quality of life and tissue repair in patients with Diabetic Foot Ulcers after irradiation with systemic Photobiomodulation: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-18	Departamento de Fisioterapia da Universidade Federal do Ceará	Departamento de Fisioterapia da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9s3dcs4	<NULL>	diabetic volunteers of both genders; aged between 18 and 75 years; with non-infected diabetic foot wounds	volunteers with infected wounds; with cognitive deficits; carriers of autoimmune diseases; bilateral upper limb amputees; carriers of other skin diseases in addition to diabetic wounds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-98zsxkw	Efficacy of In-office Bleaching with an attachable syringe varying the application tip: double-blind randomized clinical trial	Not yet recruiting	Intervention	2024-12-17	<NULL>	<NULL>	7601	Efficacy of In-office Bleaching using 35% Hydrogen Peroxide in an attachable syringe varying the application tip: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-98zsxkw	<NULL>	Volunteers of both genders will be included in the study; with a minimum age of 18 years; with good general and oral health; with teeth free of carious lesions; gingival recessions and periodontal disease in the anterior region; who agree with the informed consent (ICF) and one of their canines must be A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany)	Volunteers who have performed a bleaching procedure previously will be excluded from the study; who have reported the presence of previous tooth sensitivity; presence of dental prosthesis; fixed orthodontic appliance; restorations in maxillary anterior teeth; endodontic treatment in maxillary anterior teeth; gingival recessions; teeth with tetracycline staining or fluorosis; visible cracks in the teeth; continuous use of medications such as analgesics and anti-inflammatories; pregnant or lactating women and those with habits such as bruxism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-76nr4dg	Use of Coconut Oil and laser for selective removal of Dental Caries	Recruiting	Intervention	2024-12-17	<NULL>	<NULL>	7602	Clinical evaluation of Coconut Oil gel for selective removal of carious tissue associated with Antimicrobial Photodynamic Therapy: a double-blind randomized clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-11-20	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-76nr4dg	<NULL>	Patients aged 5 to 18 years, classified according to WHO (2023) as children (5-9 years) and adolescents (10-18 years); Patients with occlusal or occlusoproximal caries lesions in the inner half of dentin (moderate or deep); Patients with pulp vitality evidenced by radiographic examination showing the absence of periapical lesions and furcation involvement; Patients in good general health and without medical conditions that could interfere with participation in the study; Patients who agree to participate in the study by signing the Informed Assent Form (TALE), or for minors, the parents and/or guardians signing the Informed Consent Form (TCLE)	Patients with extensive carious lesions that require endodontic treatment or tooth extraction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-94vkgvp	Impact of a Culinary and Dietetics Program on cooking skills, food quality, food insecurity and stress in university students	Recruitment completed	Intervention	2024-12-16	<NULL>	<NULL>	7592	Impact of Culinary and Dietetics Intervetions on cooking skills, diet quality, food insecurity and perceived stress in university students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-94vkgvp	<NULL>	Students of both sexes; aged 18 years or older; who are actively enrolled in Federal University of Rio Grande do Norte courses; show interest and availability to attend classes in the theoretical-practical course in cooking and dietetics; have access to a kitchen that contains utensils and basic equipment for preparing food	Pregnant students; nursing students	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-263nf22	EBRAHIP-120: Brazilian randomized controlled trial of uncemented and hybrid hip replacement surgery	Recruiting	Intervention	2024-12-16	<NULL>	<NULL>	7593	EBRAHIP-120: Brazilian randomized controlled trial of uncemented and hybrid hip arthroplasty.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-19	Suprema -  Sociedade Universitária para o Ensino Médico Assistencial	Hospital e Maternidade Therezinha de Jesus	https://ensaiosclinicos.gov.br/rg/RBR-263nf22	<NULL>	Inclusion criteria include age between 40 and 80 years old; with clinical and radiographic diagnosis of hip arthritis (both primary or secondary); uni or bilateral; both sexes	We will exclude patients with pathological fractures; metabolic and/or rheumatic diseases; patients with acetabular defects that require bone graft for correction; type III protrusio acetabuli deformity; patient with history of previous infection of the hip	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-9jv6nh4	Experimental dentifrice based on Red Propolis on orthodontic patients	Data analysis completed	Intervention	2024-12-16	<NULL>	<NULL>	7594	Analysis of Volatile Sulfur Compounds (VSC) pre and post therapy with Red Propolis toothpaste. Comparative periodontal and microbiological evaluation in patients using self-ligating orthodontic appliances and patients not undergoing orthodontic treatment	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Centro Universitário Hermínio Ometto	Centro Universitário Hermínio Ometto	https://ensaiosclinicos.gov.br/rg/RBR-9jv6nh4	<NULL>	Patients had good systemic health; age between 14 and 30 years old; both sexes	Use of antibiotic therapy in the last six months; use of anti-inflammatories in the last three months; smoking; pregnancy; fixed prosthesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-7rc2t5j	Effect of Transcutaneous Radiation in Hypertensive Patients: Application to the Radial Artery	Recruitment completed	Intervention	2024-12-16	<NULL>	<NULL>	7595	Effectiveness of Photobiomodulation in Hypertensive patients: transdermal application in radial artery	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Instituto de Ciência e Educação de São Paulo	Instituto de Ciências e Tecnologia da Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7rc2t5j	<NULL>	Patients diagnosed with grade I and II hypertension according to the VII Brazilian Guideline for Arterial Hypertension; both sexes; age between 50 and 70 years; Body Mass Index (BMI) between 18 and 30 kg/m²; classified as slightly active and irregularly active according to criteria established by the International Physical Activity Questionnaire, short version (IPAQ); registered and monitored by the Family Health Strategy team, in the Hiperdia Program; residing in the city of Bocaina- PI; who are available to participate in the treatment plan and have preserved cognitive capacity	Patients with comorbidities or associated complications such as uncontrolled diabetes and dialysis patients; history of neoplasms; pregnant women; breastfeeding women; alcoholics; smokers;  electronic implants; patients temporarily away from home	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-524vx5c	Study of the use of Fractional Microablative CO2 LASER in the treatment of urinary symptoms in menopause	Recruitment completed	Intervention	2024-12-16	<NULL>	<NULL>	7597	The use of Fractional Microablative CO2 LASER in the treatment of urinary symptoms of Menopausal Genitourinary Syndrome: a prospective cohort	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-524vx5c	<NULL>	Postmenopausal women defined by a physiological state, characterized by amenorrhea lasting more than one year, plasma follicle-stimulating hormone (FSH) levels greater than 40 U/l, and estradiol levels less than or equal to 25 pg/mL. Aged 45 years or older but younger than 80 years. Patients experiencing clinical symptoms of genitourinary syndrome of menopause (dryness, burning, stinging, vaginal itching, dyspareunia, and/or dysuria). Patients who exhibit clinical symptoms of urinary incontinence. Patients diagnosed via urodynamic study with stress urinary incontinence, overactive bladder, or mixed urinary incontinence. Patients with a cervical cytology exam within the last 6 months negative for neoplasia (for women over 65 years, the last negative cytology exam within the screening period established by the local Ministry of Health). Patients with a normal urine analysis (EAS – Elements of Abnormal Sediment), without any signs of urinary tract infection	Explicit refusal by the patient to participate in the study. Patients who have undergone surgical interventions to correct urinary incontinence at any time. Patients with urinary incontinence not directly or indirectly related to genitourinary syndrome of menopause (GSM), such as patients with neurogenic bladder. Patients with active genital infections (clinical and colposcopic diagnosis). Patients with a history of genital herpes who do not agree to prophylaxis with oral Acyclovir. Patients with a history of ulcerative colitis, Crohn&apos;s disease, or diarrhea due to intestinal disease, positive serology for HIV, hepatitis B, C, or genital condylomatosis. Immunosuppressed patients, chronic users of corticosteroids, patients with scleroderma, collagen diseases, or genitourinary tract neoplasia. Patients with thrombophilias or chronic users of anticoagulants or antiplatelet drugs. Patients with second or third-degree vaginal prolapse according to the Pelvic Organ Prolapse Quantification System (POP-Q). Patients with a history of photosensitivity. Patients who have previously undergone CO2 endovaginal laser treatment at any time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-3kcsy25	8-week Mindfulness Based Taining for parents of children with Autism and impact assesment on indices of Anxiety, Stress, Depression, Life Satisfaction, and Mindfulness	Recruitment completed	Intervention	2024-12-16	<NULL>	<NULL>	7598	8-week Mindfulness Based Taining for parents of children with Autism Spectrum Disorder and impact assesment on indices of Anxiety, Stress, Depression, Life Satisfaction, and Mindfulness	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3kcsy25	<NULL>	Be parents of children between 5 months and 14 years of age who have a diagnosis of autism spectrum disorder established according to the DSM-V criteria. Accept and be available to participate in one of the 2 mindfulness intervention groups for 8 weeks (8 meetings of approximately 2 hours) to be held online via the Zoom platform. Agree to complete the pre- and post-intervention questionnaires, as well as the Informed Consent Form (TCLE - Termo de Consentimento Livre e Esclarecido) and a health screening questionnaire.	Patients who are unable to attend online sessions at the scheduled times, either due to lack of availability or adequate equipment (computer with webcam, headphones, microphone, and broadband internet). Patients with more than 2 absences from the program or who miss the first or second session of the program. Participants with a diagnosis of a serious illness such as cancer, epilepsy. Participants with a diagnosis of an uncontrolled psychiatric disorder: schizophrenia, bipolar disorder, severe depression.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-2tyjxf2	Comparison of two surgical techniques for treating recent achilles tendon injuries: a clinical study	Not yet recruiting	Intervention	2024-12-14	<NULL>	<NULL>	7590	Comparison of two Surgical techniques of Acute Injury Repair in the Achilles Tendon: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-02	Instituto de Ciências da Saúde da Universidade Federal do Pará - ICS/ UFPA	Hospital Maradei	https://ensaiosclinicos.gov.br/rg/RBR-2tyjxf2	<NULL>	18 to 60 years old; both sexes; closed Achilles tendon injury with up to 21 days of evolution; non insertional Achilles tendon injury	Bilateral injury; history of previous surgery on the lower limb with injury; rerupture; diabetes mellitus; neurovascular disease; immunosuppressive therapy; use of drug from the fluoroquinolone group; patient who does not attend the return appointment; patient who does not follow the rehabilitation protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-4w622cw	Physical exercise program for elderly people with physical fragility	Data analysis completed	Intervention	2024-12-14	<NULL>	<NULL>	7591	Geti: biopsychosocial and environmental study of individuals in third age	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-10	Fundação Universidade do Estado de Santa Catarina	Fundação Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4w622cw	<NULL>	Be 80 years of age or older; both sexes; preserved cognitive function and physical frailty	Those who present a contraindication to the practice of physical activity or any other type of activity will be excluded. Other activity proposed by GETI, have a declared or confirmed physical disability and sequelae of pathologies neurological	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-2c67h58	Comparing Treatments for bleeding control and palate healing after soft Tissue Graft removal	Recruitment completed	Intervention	2024-12-13	<NULL>	<NULL>	7587	Comparison of different hemostatic treatments and morbidity control and palate healing after soft tissue graft removal: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-03	Universidade Federal de Santa Catarina	Centro de Ensino e Pesquisa em Implantes Dentários	https://ensaiosclinicos.gov.br/rg/RBR-2c67h58	<NULL>	Patients over 18 years of age; of both genders; without significant systemic impairments in the preoperative phase; with good oral hygiene, defined by a plaque index of 25% or less; indicated for periodontal plastic surgery using a soft tissue graft; with no history of soft tissue removal from the palate	Patients with significant systemic disorders; those using anticoagulant or antiplatelet drugs; pregnant women; smokers; those with clinical and/or radiographic signs of periapical pathologies; untreated periodontal disease at the surgical site; individuals allergic to polymers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-4w44wkd	Evaluation of photoprotection activity	Recruitment completed	Intervention	2024-12-13	<NULL>	<NULL>	7588	Evaluation of a semi-solid formulation containing a combination of free and nanoencapsulated natural products for protection against solar radiation	<NULL>	1, single-arm-study, double-blind	1	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4w44wkd	<NULL>	Healthy individuals;individuals aged 20-35 years;individuals with no history of dermatological disease;both sexes.	Individuals with skin lesions in the forearm area;individuals under 20 years of age or over 35 years of age;individuals with allergies to the components of the formulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-2rdwd3y	Development of advanced automatic systems and treatment protocols for hand rehabilitation	Recruiting	Intervention	2024-12-13	<NULL>	<NULL>	7589	Development of methods and intelligent systems for upper limb rehabilitation	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2024-08-05	Instituto de Ensino e Pesquisa Alberto Santos Dumont	Universidade Federal do Espirito Santo (UFES)	https://ensaiosclinicos.gov.br/rg/RBR-2rdwd3y	<NULL>	Individuals diagnosed with traumatic spinal cord; injury classified as having complete or incomplete tetraplegia (ASIA); with neurologic levels C4–C7; aged between 18 and 60 years; of both sexes; who exhibit some level of motor deficit in the upper limbs and possess adequate cervical control to support the use of virtual reality devices; individuals who are able to attend the intervention site	Participants presenting symptoms of dysautonomia and postural hypotension; presence of skin lesions; uncontrolled pain in the upper limbs; inadequate cervical control for supporting virtual reality devices for an appropriate duration; contractures and/or spasticity(classified by the modified Ashworth scale as grade 2 or higher); surgical procedures (e.g., tendon transfers) or orthopedic trauma (e.g., fracture) within the past 3 months; mechanical ventilation and participants unable to comprehend the information provided in the informed consent or unable to provide valid consent will be excluded; individuals who experience significant discomfort during the proposed activities; those who miss two consecutive sessions; or three alternating sessions during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-3frh5bp	Facilitation of brain activity and motor training in children with autism spectrum disorder	Recruiting	Intervention	2024-12-12	<NULL>	<NULL>	7586	Facilitation of left dorsolateral prefrontal activity using tDCS and neurofunctional training in children with autism spectrum disorder: a randomized, placebo-controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-16	Universidade Evangélica de Goiás	Follow Kids - Clinica de Neuro Reabilitação Infantil	https://ensaiosclinicos.gov.br/rg/RBR-3frh5bp	<NULL>	Diagnosis of autism spectrum disorder confirmed through clinical examination; have a standardized neurobehavioral assessment that confirms and categorizes the severity of autism spectrum disorder; children levels I, II and III according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V); age between three and eight years of age; children who demonstrate sufficient response to understand simple verbal commands; no medication changes at least six months before the start of the study and during its execution; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-76xj9g4	Replication of carotid artery response to Cold Pressor Test in young adults	Recruiting	Intervention	2024-12-11	<NULL>	<NULL>	7585	Reproducibility of carotid artery reactivity to the Cold Pressor Test in young adults	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-15	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-76xj9g4	<NULL>	Men and women; 18 to 40 years old; no diagnosis or history of cardiovascular disease	Participants who report a history of cardiovascular or metabolic diseases, infectious or inflammatory processes; waist-to-height ratio greater than 0.5; smokers; people who use drugs that may influence the variables analyzed; very active or sedentary people; women with intrauterine device	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-9nsmj66	The effects of Transcranial Direct Current Stimulation in women with Chronic Pelvic Pain	Recruiting	Intervention	2024-12-11	<NULL>	<NULL>	8189	The effects of Transcranial Direct Current Stimulation on pain, functioning and kinesiophobia in women with Chronic Pelvic Pain: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-15	Maternidade Escola Assis Chateaubriand da Universidade Federal do Ceará - MEAC/UFC	Universidade federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9nsmj66	<NULL>	Female participants; with a clinical diagnosis of Chronic Pelvic Pain that persists for at least six months; aged eighteen to forty-five years; with a score greater than or equal to three on the Numerical Pain Scale	Pregnant or lactating women will be excluded; those with cognitive dysfunction; those with diagnosed central neurological diseases; those with diagnosed but untreated psychiatric diseases; those with oncological diseases; those with metal implants and or pacemakers; those with a history of epilepsy and or seizures; those with chronic musculoskeletal conditions that overlap with Chronic Pelvic Pain; those with chronic skin diseases and or scalp lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-2r72f8v	Paste based on Zinc Oxide, Iodoform and Calcium Hydroxide Manipulated for filling root canals of primary teeth: double-blind randomized controlled clinical study	Recruiting	Intervention	2024-12-10	<NULL>	<NULL>	7582	Paste based on Zinc Oxide, Iodoform, and Calcium Hydroxide Manipulated for root canal filling of deciduous teeth: a double-blind randomized controlled clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-15	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2r72f8v	<NULL>	Children of both sexes; aged between 3 and 8 years; who have at least one deciduous lower molar diagnosed with irreversible pulpitis or pulp necrosis resulting from deep caries lesions with indication for radical endodontic treatment (pulpectomy)	Children with systemic involvement; who have a history of allergy to local anesthesia or any component present in the materials to be used; the deciduous lower molar presents radiographic signs of involvement of the crypt of the permanent successor tooth germ; the deciduous lower molar presents extensive coronal destruction that cannot be restored; the deciduous lower molar presents extensive coronal destruction that cannot be isolated; the deciduous lower molar presents pathological mobility; the deciduous lower molar presents root resorption greater than one third of the root; the deciduous lower molar presents a perforated pulp floor; the deciduous lower molar presents radiographic evidence of excessive internal or external root resorption; the deciduous lower molar presents excessive bone loss in the bifurcation area involving the underlying permanent successor tooth germ; the deciduous lower molar presents some of the root canals obliterated; the deciduous lower molar has undergone previous endodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-7dvgwyr	Effects physical exercise on moviment, pain, memory, attention, welfare in patients with chronic pain	Recruiting	Intervention	2024-12-10	<NULL>	<NULL>	7583	Effects of physical exercise practice on motor behavior, pain intensity, cognitive and psychological aspects and quality of life in patients with chronic pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7dvgwyr	<NULL>	Be over 18 years of age; men and women; present a medical certificate to participate in evaluations and physical exercise practice; have persistent musculoskeletal pain lasting 6 months or longer; be sedentary (not engaging in 150 minutes or more of moderate aerobic activity per week); demonstrate understanding of the questionnaires, tests/scales, and instructions/guidelines during evaluations and physical exercise practice	Presenting restrictions that make it impossible to carry out assessments and practice physical exercises; present a medical diagnosis of dementia;  have symptoms of COVID-19;  not carrying out all the procedures foreseen in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-5jrdd7c	Effect of Infant Massage on premature babies admitted to the hospital	Recruiting	Intervention	2024-12-10	<NULL>	<NULL>	7584	Effect of Therapeutic Infant Massage on premature babies admitted to the care unit neonatal intermediates	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-04	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-5jrdd7c	<NULL>	Gestational age between 32 and 36 weeks; birth weight greater than or equal to 1500 grams;  hospitalization in the Neonatal Intensive Care Unit - NICU; clinical stability; chronological age between 3 and 28 days; both genders; and authorization from parents/guardians through the Informed Consent Form -  ICF	Newborns who, during the research, present hemodynamic instability, reaction allergic to vegetable oil, need for emergency surgery; if discharged before the end of the research; if transferred to another hospital; if the person responsible decides to discontinue participation in any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-8ggp2cx	Use of Thermal Mattress before Anesthesia to prevent temperature drop and its effect on Mental Capacity	Recruiting	Intervention	2024-12-09	<NULL>	<NULL>	7580	Evaluation of the effectiveness of Peri-induction Warming with a Thermal Mattress in preventing Perioperative Hypothermia and its impact on cognitive function assessed by CogniFit	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Impar Serviços Hospitalares S/A	Centro de Ensino e Treinamento Hospital Regional do Gama	https://ensaiosclinicos.gov.br/rg/RBR-8ggp2cx	<NULL>	Patients between 65 and 80 years of age of both genders; procedures under general anesthesia with an estimated duration of 60 to 180 minutes; physical status classified as American Society of Anesthesiologists (ASA) I a III	Patients with preoperative fever (&gt; 38.0°C) or hypothermia (&lt; 36.0°C); history of encephalopathy, autonomic neuropathy, thyroid dysfunction, risk of malignant hyperthermia, or neurological or cognitive diseases; patients with a Body Mass Index (BMI) over 35 kg/m²; preoperative tympanic body temperature outside the range of 36°C to 38°C; patients referred to the Intensive Care Unit (ICU) during the post-anesthetic recovery period; patients diagnosed with uncompensated thyroid disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-79fw26y	Transcranial direct current stimulation (tDCS) and augmentative and alternative communication for children with cerebral palsy	Array	Intervention	2024-12-09	<NULL>	<NULL>	7581	Transcranial direct current stimulation and augmentative and alternative communication for children with cerebral palsy: a double-blind, randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-03	Universidade Evangélica de Goiás	Follow Kids - Clinica de Neuro Reabilitação Infantil	https://ensaiosclinicos.gov.br/rg/RBR-79fw26y	<NULL>	Diagnosis of cerebral palsy; both genders; age between six and twelve Years; children levels III, IV and V of the communication function classification system; statement of informed consent signed by a legal guardian; statement of informed assent signed by the participant	Children with neurological, neuromuscular diseases or syndromes associated with cerebral palsy; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-6vnrmfn	Effect of Buriti supplementation compared to whey protein in healthy young adults undergoing physical exercise	Not yet recruiting	Intervention	2024-12-08	<NULL>	<NULL>	7579	Effect of Hyperproteic Supplementation Based on Buriti (Mauritia Flexuosa) Versus Whey Protein in Healthy Young Adults Undergoing Physical Exercise: A Randomized, Blind, Controlled Pilot Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-6vnrmfn	<NULL>	The study will enroll men and women; aged between 18 and 35 years; who are apparently healthy according to the criteria of the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+); and classified as insufficiently active or sedentary based on the International Physical Activity Questionnaire (IPAQ)	Individuals with musculoskeletal injuries that limit the capacity for moderate and vigorous exercise during the study period; neoplastic, hepatic, renal, or cardiovascular disorders; malabsorption disorders; those consuming anti-inflammatory drugs, analgesics, antibiotics, or vitamin and mineral supplements during the study period; individuals on medications affecting metabolic profile; and vegetarians will be excluded. Additional exclusion criteria will include pregnancy and breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-5ct5f9w	Analysis of Gingival Healing Bordering Prosthetic Abutments with Treated Surface	Recruitment completed	Intervention	2024-12-06	<NULL>	<NULL>	7576	Histological and Histomorphometric Analysis of Gingival Healing at the Interface of Prosthetic Abutments treated with Anodization	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-5ct5f9w	<NULL>	Patients of both sexes; partial edentulousness in the posterior maxilla; with absence of at least two teeth, whether contiguous or not; healed ridges that do not require tissue evacuation for subsequent implant installation; implants installed with primary stability; mucosal thickness on the ridge crest minimum of 2 mm in height of the keratinized tissue	Patients who require some type of advanced bone or surgical assistance to allow implant installation; with systemic contraindication to the surgical procedure or conditions that interfere with the osseointegration process	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-9g8mrfg	Low Power Laser, therapeutic ultrasound and artificial intelligence in arthralgia and temporomandibular disorders: randomized clinical trial	Recruiting	Intervention	2024-12-06	<NULL>	<NULL>	7577	Photobiomodulation, therapeutic Ultrasound and Artificial Intelligence in arthralgias and Temporomandibular Myogenic Disorders: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Centro de Ciência da Saúde da Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9g8mrfg	<NULL>	Women aged 18 to 55 years who are diagnosed with joint or muscular temporomandibular disorder according to the Diagnostic Criteria for Temporomandibular Disorders DC/TMD; women who are not pregnant and/or who use a pacemaker; without rheumatological diseases; individuals who do not have cognitive deficits; individuals who do not have syndromes; do not use pain medications during the research period; onset of symptoms of at least 6 months; VAS visual analogue scale less than 7; agree and sign the Informed Consent Form (TCLE)	All patients who do not comply with all steps of the research protocol; patients who withdraw from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-438qrmr	Footcore Exercises on variables of running	Data analysis completed	Intervention	2024-12-06	<NULL>	<NULL>	7578	The influence of Footcore Exercises on the biomechanical variables of running, stability and functionality of lower limbs in street runners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade de Caxias do Sul	Universidade de Caxias do Sul	https://ensaiosclinicos.gov.br/rg/RBR-438qrmr	<NULL>	Long-distance runners of both sexes; aged 18 to 45 years; trained running on the street regularly at least three times a week, totaling between 20 km to 100 km per week; had been practicing the modality for at least one year; agreed to participate in the study voluntarily and presented a signed Informed Consent Form	Had any cardiorespiratory, neuromuscular, or metabolic disease preventing participation; had cognitive or motor deficits and musculoskeletal diseases; presented the following absolute contraindications: soft tissue healing; severe pain; severe joint effusion; acute injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-10nbcsbw	Functional Exercise: a new approach to managing Systemic Sclerosis	Recruiting	Intervention	2024-12-05	<NULL>	<NULL>	7570	Efficacy of an Exercise Program based on functional activities in the disability of individuals with Systemic Sclerosis: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-27	Departamento de Fisioterapia da Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10nbcsbw	<NULL>	Adults (18-65 years); both sexes; with a Scleroderma Health Assessment Questionnaire score of 1 or higher; and a diagnosis of Systemic Sclerosis according to the 2013 American College of Rheumatology / European League Against Rheumatism (ACR/EULAR) classification criteria	Pregnancy; diagnosis of malignancy; changes in drug treatment in the last three months; physical therapy care in the last three months; overlap with other autoimmune rheumatic diseases; dysfunctions that limit physical activity, such as severe neurological impairment, immobility or cooperation deficits; individuals who have a regular exercise habit (at least three days per week); New York Heart Association level III or IV classification; joint surgery in the six months prior to inclusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-45bk3sw	Efficacy of In-office Bleaching with Self-mixed reducing application time: a single-blind randomized clinical trial	Not yet recruiting	Intervention	2024-12-05	<NULL>	<NULL>	7571	Efficacy of in-office Bleaching using 35% Self-mixed Hydrogen Peroxide reducing application time: a single-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-45bk3sw	<NULL>	Volunteers aged at least 18 years; both sexes; with good general and oral health; with teeth free of caries and periodontal disease in the anterior region; who agree to the free and informed consent form (FICF) and whose canines must have A2 color or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany)	Volunteers who have previously undergone a whitening procedure; who have reported the presence of previous dental sensitivity; presence of dental prosthesis; fixed orthodontic appliance; restorations in the upper anterior teeth; endodontic treatment in the upper anterior teeth; gingival recessions; teeth with tetracycline staining or fluorosis; continuous use of medications such as analgesics and anti-inflammatories; pregnant or lactating women and those with habits such as bruxism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-3mcg82f	FotoBio-HIV: evaluation of Laser Therapy on Inflammatory, Immunological, and Coagulation Processes in People Living with HIV/AIDS	Not yet recruiting	Intervention	2024-12-05	<NULL>	<NULL>	7572	PhotoBio-HIV: evaluation of the effects of Vascular Photobiomodulation on Inflammatory, Immunological, and Coagulation Biomarkers in people living with HIV/AIDS – clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3mcg82f	<NULL>	Participants must have been diagnosed with HIV/AIDS for at least one year; be over 18 years of age; both sexes; be on regular antiretroviral therapy for at least six consecutive months; be in viral suppression (undetectable or less than the minimum limit); must not present active opportunistic infections at the time of study enrollment	People under 18; pregnant women; patients with active opportunistic infections; history of neoplasms; carriers of active electronic implants such as cardiac pacemakers; those with a history of epilepsy or seizures; people with known photosensitivity conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-5v8vtr4	Effects of multimodal training on cardiovascular risk in hypertensive elderly people	Recruitment completed	Intervention	2024-12-05	<NULL>	<NULL>	7575	Effects of Aerobic training on cardiorenal adaptations and Cardiac autonomic modulation in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-5v8vtr4	<NULL>	Be aged ≥60 years. Be normotensive or controlled hypertensive. Be sedentary. Have the cognitive ability to understand the research process. Sign the free and informed consent form	Attendance at training sessions below 85%. Do not respond to questionnaires. Present systolic blood pressure greater than or equal to 160 mmHg and diastolic blood pressure greater than or equal to 100 mmHg recurrently in 3 training sessions. Not using your antihypertensive medication regularly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-9stskc6	Effect of Acupuncture on anxious symptoms of healthcare students with Generalized anxiety disorder: randomized controlled clinical trial	Not yet recruiting	Intervention	2024-12-04	<NULL>	<NULL>	7565	Effect of Acupuncture on anxious symptoms in healthcare students: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Instituto de Patologia Tropical e Saúde Pública da Universidade Federal de Goiás	Instituto de Patologia Tropical e Saúde Pública da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9stskc6	<NULL>	Students with symptoms of generalized anxiety even with conventional treatment (Generalized Anxiety Disorder Scale greater than 10); previous diagnosis by a psychiatrist according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders for generalized anxiety disorder; and students in the health area, regularly enrolled in the educational institution; over 18 years old; both sexes	Current psychosis and psychosis in the last 6 months; substance dependence in the last 6 months; severe depression that is significantly more relevant than generalized anxiety disorder; pregnancy or postpartum women; having undergone acupuncture treatment in the last 30 days; intolerance to acupuncture (needle phobia); students who are taking the subject of Acupuncture and Medical Homeopathy, and students who have completed less than 1 year of graduation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-54ymm8f	Tissue and molecular changes associated with fractional CO2 laser in women with vulvar lichen sclerosus	Recruitment completed	Intervention	2024-12-04	<NULL>	<NULL>	7566	Immunohistochemical alterations associated with fractional CO2 laser in women with vulvar lichen sclerosus: a step in understanding the mechanisms involved in an adequate therapeutic response	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-14	Universidade Federal de São Paulo (UNIFESP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-54ymm8f	<NULL>	Patients aged 45 to 85 years; clinical diagnosis of vulvar lichen sclerosus; treatment-naïve or refractory to high-potency corticosteroid therapy.	Absence of the characteristic hyalinized band in the dermis superficial to histology in the first biopsy performed; association with neoplasms in the stratum corneum; genital infectious or inflammatory comorbidities at the time of recruitment; hx of vulvar radiotherapy; collagenoses or other autoimmune diseases involving connective tissue; immunosuppression or use of systemic immunosuppressive drugs; gynecological surgeries in a period of less than 6 months; and whether they were treated with topical corticosteroid therapy, pimecrolimus, tacrolimus, or any other topical therapy known or suspected to have an effect on vulvar lichen sclerosus or its symptoms in the 4 weeks prior to study entry.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-59j57vj	Effect of Magnesium Chloride supplementation on Depression	Data analysis completed	Intervention	2024-12-04	<NULL>	<NULL>	7567	Effect of magnesium chloride supplementation on brain electrical activity in individuals with depression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-59j57vj	<NULL>	Volunteers diagnosed with depression, both sexes, between 18 and 60 years old, both sexes, with stable use of antidepressants and no change in the treatment plan in the last 2 months, with weight within the limit of variation of 15% of the weight considered normal for men and women.	Individuals with associated psychiatric clinical conditions or other clinically unstable pathologies, alcohol and/or illicit substance abuse, gastrointestinal disease, pregnant or trying to get pregnant and individuals with surgery planned within the next 6 months were excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-9fjmcnp	Use of Bergamot Essential Oil to reduce Stress and Anxiety in public school teachers in Lajedo-PE: A clinical study	Not yet recruiting	Intervention	2024-12-04	<NULL>	<NULL>	7568	Use of Citrus bergamia Essential Oil in the management of Stress and Anxiety in public school teachers in the city of Lajedo-PE: A single-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-16	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9fjmcnp	<NULL>	Being a teacher in the public education network in the municipality of Lajedo-PE; be in full performance of their activities; be between 25 and 60 years old	People with upper airway obstruction problems at the time of the experiment; people with uncontrolled chronic respiratory diseases; people undergoing treatment with psychotropic medications or who have neurological and/or psychiatric comorbidities that affect cognition; people with a history of adverse reactions to aromatic products; present a score on the DASS-21 questionnaire, as defined by a score below 8 for anxiety and 15 for stress	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-2cb5qk5	Sleep quality, knowledge about nutrition, beliefs and eating habits of ultramarathoners	Recruitment completed	Observational	2024-12-03	<NULL>	<NULL>	7555	Sleep pattern, nutritional knowledge, beliefs and eating habits of ultramarathon athletes.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade de Ciências Aplicadas da Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2cb5qk5	<NULL>	Athletes must be healthy, male ultramarathon runners, over 18 years old, participating in the Brazil 135 Ultramarathon race in the 217 km solo category, with previous experience in at least two other internationally recognized races. Support must be a pacer or coach who is closest to the athlete on a daily basis and who can influence the strategies that the athlete executes during the race	Adults with motor or cognitive limitations that compromise the performance of the evaluations proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-4mdcbcg	clínical evaluation of the plastic retainers on speech	Recruitment completed	Intervention	2024-12-03	<NULL>	<NULL>	7556	clínical evaluation of the plastic retainers on speech patterns	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Centro Universitário da Fundação Hermínio Ometto	Centro Universitário da Fundação Hermínio Ometto	https://ensaiosclinicos.gov.br/rg/RBR-4mdcbcg	<NULL>	Volunteers treated with angle class I malocclusion with mild or moderate crowding; who has received orthodontic treatment without extraction; with fixed lip appliance on both arches; exposed to a monolingual environment	Overhang greater than 4 mm; anterior open bite malocclusion; anterior or posterior crossbite malocclusion; changes in speech production; tongue protrusion habit; cleft lip or palate; surgical correction of the jaws; hearing disorder; presence of temporomandibular dysfunction; presence of severe periodontitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-92s874h	Memory and obesity: the impact of a calorie-restricted diet on neuroplasticity	Recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7557	Evaluation of adult hippocampal neuroplasticity in obesity: cognitive and biochemical impacts of a caloric restriction protocol, a randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-92s874h	<NULL>	Individuals of both sexes; aged between 21 and 51 years; diagnosed with grade I and II obesity taking into account height and physical structure	Individuals who have liver disease with the exception of hepatic steatosis; kidney disease, cardiovascular disease, type 1 diabetes mellitus, fibromyalgia, cancer and epilepsy; uncontrolled depression; post-bariatric surgery; shift workers; women who are pregnant or lactating or who are planning and undergoing treatment to become pregnant; patients taking slimming drugs; a history of excessive alcohol use or substance abuse; individuals who have experienced significant weight loss in the last six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-6rjywnq	Tin fluoride solution and fluoride toothpaste in the control of erosive tooth wear	Recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7558	Effect of the combined use of tin fluoride solution and fluoride toothpaste in the control of erosive tooth wear in enamel, dentin and the protein composition of acquired salivary film: an in situ and in vivo study	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6rjywnq	<NULL>	individuals of both sexes; aged 18 years or older; good general health	individuals who have self-reported gastroesophageal reflux; pregnant women; individuals using orthodontic appliance; individuals with special needs; individuals with difficulties in understanding the protocol and its guidelines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-7nq5sqn	EN23-0216-04_Evaluation of skin irritation and allergy caused by light	Not yet recruiting	Observational	2024-12-03	<NULL>	<NULL>	7559	EN23-0216-04_Dermatological evaluation of topical phototoxicity and photosensitization potential	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2025-01-15	Universidade São Francisco	Medcin Instituto da Pele Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7nq5sqn	<NULL>	Participants of both sexes; age between 18 and 70 years; phototype II or III (adapted Fitzpatrick scale); intact skin in the application area; agreement to follow the trial procedures; attendance at the clinic on scheduled dates and times for medical evaluations and application and reading of patches; understanding and signing of the Informed Consent Form (ICF)	Pregnant or breastfeeding women; use of anti-inflammatory drugs in the last 30 days and immunosuppressive drugs in the last three months; immunosuppression due to medication or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before or during the study; anticipated intense sun exposure or tanning sessions during the study; planned sea bathing, swimming pool, or sauna sessions during the study; practice of water sports; dermographism; use of oral or topical vitamin A acid treatments or derivatives up to one week before the study; aesthetic or dermatological treatments on the body within three weeks before the study; scheduled vaccination up to three weeks before or during the study; history of sensitivity, irritation, or photosensitization to topical products; active skin conditions that may interfere with the study results; use of new medications or cosmetics during the study; skin reactivity; congenital or acquired immunodeficiency; significant history or current evidence of alcohol or drug abuse; conditions aggravated by UV radiation; use of photosensitizing drugs; history or activity of photodermatoses; personal or family history of skin cancer; presence of precancerous skin lesions, such as melanocytic nevi and actinic keratoses; lack of adherence to the protocol; employees of Medcin or the sponsoring company involved in the study or close relatives of employees; other conditions considered by the researcher to disqualify participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-2k34tmb	Comparison of orthodontic and speech therapy effects between different mandibular expanders devices: Williams and Schwarz	Recruitment completed	Intervention	2024-12-03	<NULL>	<NULL>	7560	Comparison of dentoskeletal effects and orofacial functions between the Williams and Schwarz expanders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-12	Faculdade de Odontologia de Bauru da Universidade de São Paulo (FOB - USP)	Faculdade de Odontologia de Bauru da Universidade de São Paulo (FOB - USP)	https://ensaiosclinicos.gov.br/rg/RBR-2k34tmb	<NULL>	Both sexes; 6 to 11 years; mixed dentition; Class I malocclusion; atresia of the upper and lower dental arch; mild to moderate crowding of the lower dental arch	Patients with a history of previous orthodontic treatment or extraction of permanent teeth; patients with systemic or neurological alterations that difficult orthodontic therapy; presence of craniofacial syndromes or anomalies; loss of deciduous mandibular canines and second molars; presence of tooth agenesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-58wdpvh	Clinical profile, physical and sensory aspects of patients with Blood Cancer	Not yet recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7561	Clinical profile, physical and perceptual aspects of Hemato-Oncology patients	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-58wdpvh	<NULL>	Both genders; age between 18 and 59 years old; diagnosis of hematological cancer; being treated for hematological cancer	Use of medications for pain, nausea or constipation before applying foot reflexology; present medical contraindication to practicing foot reflexology; pregnancy (1st trimester); diarrhea and/or vomiting; localized skin diseases on the feet; localized inflammation or edema in the feet;  fever; infectious diseases; extreme negative reaction to the application of foot reflexology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-4pk34zm	Clinical performance of restorations using fibers in teeth with treated canals: randomized clinical trial	Not yet recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7562	Clinical performance of fiber-based restorations in endodontically treated teeth: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-16	Faculdade de Odontologia da Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4pk34zm	<NULL>	Being men and women; at least 18 years of age; in good general and oral health; the dental elements of the study must: have a posterior tooth, with satisfactory endodontic treatment; have loss of at least one proximal wall (occluso-mesial, occluso-distal, mesio-occluso-distal cavity); being in occlusion and having adjacent teeth; have a coronary structure remaining from the buccal or palatal/lingual walls with at least one cavity wall with a thickness of less than 2 mm	Patients with poor oral hygiene; smokers; pregnant women; breastfeeding women; teeth that have color changes due to intrinsic factors (dentinogenesis and amelogenesis imperfecta, fluorosis, tetracycline);  periodontal disease; severe parafunctional habits; cervical lesions (carious and non-carious); active clasps of removable partial dentures on the tooth included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-103bvzkh	Effect of local ice before anesthesia for vulva biopsies on the comfort of outpatients	Recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7563	Effect of local cooling prior to anesthesia for vulva biopsies on the comfort of outpatients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Hospital da Mulher Prof. Dr. J. A. Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-103bvzkh	<NULL>	Women over 18; women in the process of diagnosis and treatment of Lower Genital Tract Pathologies; women with preserved motor skills (nerve and muscular functions) of the lower limbs; women with preserved local sensitivity	Previous motor deficiency in lower limbs; non-communicating patient; patients with cold urticaria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-84gy8sc	Periwalking for labor analgesia. Comparative study between two anesthetics	Not yet recruiting	Intervention	2024-12-03	<NULL>	<NULL>	7564	Epidural Block with Ultra-low doses of Local  anesthetics (Periwalking) for Labor analgesia. Comparative study between 2  anesthetics	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-12-18	Hospital da Mulher Professor Doutor José Aristodemo Pinotti	Hospital da Mulher Professor Doutor José Aristodemo Pinotti	https://ensaiosclinicos.gov.br/rg/RBR-84gy8sc	<NULL>	Primiparas on active labor; patients classified as ASA 2 in accordance with the American Society of Anesthesiologists class 2; AGE higher than 18 yo; higher than 37 weeks of gestational age; single, live fetus with cephalic position; cervical dilation higher or equal than 6 cm; without previous cesarian section	Regional anesthesia contra-indication; alergic reactions with local anesthetics;ASA3 or more; psychiatry disorders; drugadiction; age below 18yo; Body mass index 40; fetus malformation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-8ffhbk9	Cerebellar Transcranial Direct Current Stimulation and Gait Training in children with Down Syndrome	Recruiting	Intervention	2024-12-02	<NULL>	<NULL>	7552	Cerebellar Transcranial Direct Current Stimulation and Gait Training in children with Down Syndrome: a randomized, double blind controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-16	Universidade Evangélica de Goiás	Follow Kids - Clinica de Neuro Reabilitação Infantil	https://ensaiosclinicos.gov.br/rg/RBR-8ffhbk9	<NULL>	Diagnosis of Down syndrome confirmed through clinical examination and genetic investigation; age between three and eight years; both sexes; children who demonstrate sufficient response to understand simple verbal commands; no medication changes at least six months before the start of the study and during its execution; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-10pzjmbj	Evaluation of the use of human milk in the growth and development of very low birth weight premature infants	Not yet recruiting	Intervention	2024-12-02	<NULL>	<NULL>	7553	Impact of nutritional therapy with pasteurized colostrum/hypercaloric human milk on perinatal outcomes of very low birth weight preterm infants: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-17	Departamento de Nutrição da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-10pzjmbj	<NULL>	Very low birth weight newborns (VLBN) of both sexes; on an enteral diet by orogastric tube, with mother&apos;s own expressed breast milk (LMO) and pasteurized human milk (LHP) from the milk bank	Neonates diagnosed with severe congenital malformations; with congenital errors of metabolism; with chromosomal disorders; with birth weight &lt; 700 g; with gestational age at birth &lt; 23 weeks; neonates prescribed a colostrum diet, high-calorie, transitional or mature LHP; in use of human milk additive	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-7cps9tt	Assessing the impact of combining Acupuncture with Anti-nausea and Anti-vomiting medications in patients undergoing Chemotherapy treatment	Recruitment completed	Intervention	2024-12-02	<NULL>	<NULL>	7554	Evaluation of the effect of Acupuncture combined with antiemetics in the prophylaxis of Chemotherapy Induced Nausea and Vomiting	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Faculdade de Medicina de São José do Rio Preto	Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-7cps9tt	<NULL>	Female gender; Age &gt; 18 years; Diagnosis of Primary Breast Cancer; Undergoing AC Chemotherapy protocol (Doxorubicin + Cyclophosphamide)	Age &lt; 18 years; Illiteracy; presence of another Primary Cancer; presence of Metastasis; presence of Skin Lesions/Inflammations at the needling site; patient refusal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-7c7zh75	Comparison between regional techniques and spinal anesthesia associated with general anesthesia for laparoscopic gynecological surgeries - a randomized study	Not yet recruiting	Intervention	2024-12-02	<NULL>	<NULL>	7780	General Anesthesia combined with regional techniques in Laparoscopic Gynecological Surgeries, comparison between Tap Block, Quadratus Lumbar Block and Spinal Anesthesia with Opioid: randomized study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2025-05-04	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-7c7zh75	<NULL>	Patients aged 18 to 65 years; female; American Society of Anesthesiologists physical status - ASA I or II; undergoing total laparoscopic hysterectomy	Patients with severe comorbidity (American Society of Anesthesiologists physical status - ASA III or higher); cardiac arrhythmias; dilated cardiomyopathy; cardiac conduction disorder; electrolyte disorder; acid-base disorder; hypersensitivity to lidocaine; psychiatric, hepatic, respiratory or oncological diseases; patients who were receiving any type of analgesic in the week prior to surgery; patients who received blood products during the study period; and those whose health insurance does not cover the intervention procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-6c59zjb	Simultaneous TENS and exercises in knee Osteoarthritis	Not yet recruiting	Intervention	2024-11-30	<NULL>	<NULL>	7551	Previous photobiomodulation and Transcutaneous Electrical Nerve Stimulation simultaneously with therapeutic exercises in Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6c59zjb	<NULL>	Patients with knee osteoarthritis grades 2 and 3 on the Kellgren-Lawrence scale; with clinical and radiological diagnosis carried out by an independent traumatologist; age between 45 and 80 years; minimum pain of 3/10 in the numerical scale of pain; of both genders	Patients with knee osteoarthritis grades 0, 1 and 4 according to the Kellgren-Lawrence radiological classification; non-ambulatory patients; neurological diseases that lead to cognitive deficits that make it difficult to understand exercises; neuropathy; clinical manifestations that do not allow exercise; previous history of infiltration of the knee joint in the last three months; history of knee joint arthroplasty; history of knee trauma or surgery in the last six months; patients participating in another knee rehabilitation program; have undergone rehabilitation with or without transcutaneous electrical nerve stimulation (TENS) in the last 6 months; contraindications to TENS (pacemakers, dermatological lesions and changes in sensitivity in the knees); three consecutive unjustified absences	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-5mwfczh	Effectiveness of an active teaching method for learning to write a nursing prescription in the primary health care context	Recruitment completed	Intervention	2024-11-29	<NULL>	<NULL>	7548	Effectiveness of an active teaching method for learning to write a nursing prescription in the primary health care context: a pilot study	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-5mwfczh	<NULL>	Included were nursing students regularly enrolled in the aforementioned curricular component; men and women aged 18 and over; who were present at the application of both the instruments and the intervention; agreeing to the research objectives by signing the Informed Consent Form (ICF)	Students under the age of 18; participants in other projects, whether extension, research, monitoring or associated actions related to the theme concurrently with this research; scholarship holders or collaborators who contributed to the development of this study were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-7st4f9b	How Gallic Acid and Exercise impact the metabolism of Obese and Healthy Individuals	Recruiting	Intervention	2024-11-29	<NULL>	<NULL>	7549	Evaluation of the use of Gallic Acid, with or without Physical Activity, on the metabolic profile of Obese and Eutrophic individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Estadual de Montes Claros	Universidade  Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-7st4f9b	<NULL>	Men and women; aged 18 to 35 years; Body Mass Index (BMI) greater than 30 kg/m² and body fat percentage above 25%, with stable body weight over the past six months; physically inactive; to be apparently healthy according to the Physical Activity Readiness Questionnaire	Musculoskeletal injury that limits the ability to perform moderate and vigorous intensity exercise during the study period; use of anti-inflammatory drugs and/or analgesics during the study period; use of any therapy for muscle pain during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-99w93t9	Hemodynamic repercussions during upper airway aspiration with postural restraint in preterm infants	Recruitment completed	Intervention	2024-11-29	<NULL>	<NULL>	7550	Hemodynamic Repercussions during Nasotracheal Aspiration Procedure with Postural Nesting in Preterm newborns	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Obras Sociais e Educacionais de Luz	Instituto de Responsabilidade Social Sirio Libanes	https://ensaiosclinicos.gov.br/rg/RBR-99w93t9	<NULL>	Premature newborns, whose guardians agreed to the research and signed the informed consent form (ICF); premature newborns of both sexes, with more than 72 hours of life who do not meet the minimum handling criteria; premature newborns who are indicated for nasotracheal aspiration according to the criteria indicated in the literature; premature newborns aged up to 37 gestational weeks, who are hemodynamically stable on room air, using oxygen therapy or non-invasive ventilation	Full-term newborns; newborns using sedation and/or vasoactive drugs, presenting hemodynamic instability; newborns presenting severe neurological alterations; newborns on invasive ventilatory support under orotracheal intubation; newborns who meet the criteria for minimal manipulation; newborns who have composed the initial collection, and after that do not present indication for nasotracheal aspiration in the other care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-7q7vw68	Use of Dental Graft for Alveolar Repair after lower third molar Extraction	Recruitment completed	Intervention	2024-11-28	<NULL>	<NULL>	7543	Use of Autogenous Dental Grafting for Alveolar Repair: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Odontologia de Pernambuco/ UPE	Departamento de Pós-Graduação em Cirurgia e Traumatologia BucoMaxiloFacial	https://ensaiosclinicos.gov.br/rg/RBR-7q7vw68	<NULL>	Aealthy adult patients ≥ 18 years old; who need the removal of two lower third molars with adjacent second molars; who have impacted and mesioangulated lower third molars with similar positioning with the contralateral side; who have continuity of the alveolar walls after extraction; who have gingiva enough keratinized tissue to cover the grafted bone; and who spontaneously accept to participate in this research protocol and sign the Informed Consent Form	Patients with erupted or semi-impacted mandibular third molars with distoangular, vertical and horizontal positioning; with endocrine/metabolic disorders that may affect bone regeneration; with acute infection; periapical lesion; endodontic treatment; root caries; cystic lesion or tumor associated with teeth; who take/have taken bisphosphonates; smokers; who present loss of one or more alveolar walls after tooth extraction and who are unable to understand the purpose of the study or who do not accept the methodology employed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-4fc33kz	Determination of the glycemic response to the consumption of specialized oral nutritional supplement and specialized high-protein enteral formula for glycemic control	Data analysis completed	Intervention	2024-11-28	<NULL>	<NULL>	7544	Glycemic response of individuals to the consumption of enteral nutrition formula	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-06	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fc33kz	<NULL>	Healthy volunteers; aged between 18 and 45 years; both genders; with good health conditions according to a report of absence of diabetes, renal and gastrointestinal diseases and hyperthyroidism; having a Body Mass Index (BMI) within the normal range of 18.5 to 24.9 kg/m²; with normal glucose tolerance (between 70 and 99 mg/100 mL in the morning, after fasting for 10 hours) and maximum postprandial blood glucose of 140 mg/100 mL and close to fasting after 2 hours	Volunteers using any type of medication that could affect digestion and absorption of food (antibiotics, medications for diarrhea and constipation) during the study period; hormone therapy; presence of pregnancy or breastfeeding; family history of diabetes; significant glycemic variations in the glycemic response test to the reference food	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-5fgyyzm	Effects of physical training with elastic bands on physical fitness and quality of life of elderly people	Recruitment completed	Intervention	2024-11-28	<NULL>	<NULL>	7545	Effects of resistance training based on elastic bands on functional fitness and quality of life of elderly people: a randomized clinical trial	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-05	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5fgyyzm	<NULL>	Men and women over 65 years of age. Must be able to perform physical activities upon presentation of a medical certificate. Must not have performed regular physical training in the three months prior to the start of the project. Must be available to go to the higher education institution for both the assessments and the 15 intervention sessions	Have uncontrolled cardiovascular diseases or associated complications. Have musculoskeletal problems that prevent the practice of physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-28h68rq	Study to evaluate how the Yellow Fever vaccine works in individuals who have already taken the vaccine and undergone a stem cell transplant	Recruiting	Observational	2024-11-28	<NULL>	<NULL>	7546	Cross-sectional study of the immunogenicity evaluation of the Yellow Fever vaccine in individuals previously vaccinated after hematopoietic stem cell transplantation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-15	Instituto Nacional de Infectologia - INI / Fiocruz	Instituto Nacional de Infectologia - INI / Fiocruz	https://ensaiosclinicos.gov.br/rg/RBR-28h68rq	<NULL>	Individuals of both genders; aged 18 and older; post hematopoietic stem cell transplant at any time post-transplant and having received yellow fever vaccination pre-transplant; ability to comprehend and sign the informed consent form freely and with understanding	Vaccination against yellow fever after stem cell transplant; not having received yellow fever vaccination before the transplant; any condition that, in the Investigator&apos;s or their designees&apos; assessment, may hinder the provision of informed consent, make participation in the study unsafe, impair data interpretation; or in any way interfere with the achievement of the study&apos;s objectives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-2xshtyb	Neuromodulation on clinical outcomes in patients on Cancer	Recruiting	Intervention	2024-11-28	<NULL>	<NULL>	7547	Effects of Transcranial Direct Current Stimulation on pain management in Cancer patients: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-19	Faculdade de Ciências Médicas da Paraíba	Comissão Nacional de Ética em Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-2xshtyb	<NULL>	Patients of both genders; aged over 18 years; diagnosed with any type of cancer at any stage; under the care of the hospital team; having chronic musculoskeletal pain; headache or neuropathic pain reported with a score greater than 4, ranging from 1 to 10, according to the numerical pain scale; using analgesic or anti-inflammatory medication	Having any metal implant in the head; having a history of epilepsy or seizures; having any electrical implant in the body; being pregnant; showing any sign of severity of the disease or exacerbation of the condition such as hemodynamic changes, stroke or infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-8ckxj5g	How the recovery of front teeth with implants by the unified health system works: evaluating efficiency in the dental trauma clinic	Not yet recruiting	Intervention	2024-11-27	<NULL>	<NULL>	7540	Implant rehabilitation protocols for anterior tooth loss in SUS patients: analysis of effectiveness associated with the dentoalveolar trauma clinic	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-05	Faculdade de Odontologia - Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8ckxj5g	<NULL>	Patient level: age greater than 18 and less than or equal to 60 years old; both genders; anterior tooth loss (single or multiple) or tooth with indicated extraction, assessed as sufficient for surgical planning; willingness to participate and sign informed consent. Implant site level: healed anterior edentulous space (at least 8 weeks since extraction), or tooth indicated for extraction due to fracture; coronary destruction with unfeasibility of recovery; minimum ridge dimensions of 5.4 mm (width) by 12 mm (height) in the anterior region of the maxilla, allowing the installation of implants with a regular or narrow diameter and a minimum length of 10 mm	Exclusion criteria at the patient level: inability to perform adequate oral hygiene or post operative care; inability to provide written informed consent and/or compliance with the study protocol; any contraindication to oral surgery, such as (but not limited to) uncontrolled diabetes, immunosuppression, radiation, chemotherapy or anti resorptive medication such as bisphosphonates; presence of multiple posterior edentulous spaces with an indication for extensive oral rehabilitation; heavy smoking with more than 20 cigarettes/day	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-6tfbjjg	Acute effect of Electrical Stimulation of a body nerve located in the ear on heart rate and blood pressure in people with and without Hypertension	Recruiting	Intervention	2024-11-27	<NULL>	<NULL>	7541	Comparison of the acute effect of Transcutaneous Auricular Vagus Nerve Stimulation at two different sites on cardiac autonomic modulation and blood pressure in healthy and Hypertensive individuals: a randomized, crossover clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-11-03	Associação educacional nove de julho	Associação educacional nove de julho	https://ensaiosclinicos.gov.br/rg/RBR-6tfbjjg	<NULL>	Healthy individuals (without hypertension) and individuals with hypertension aged 18 years or older of both sexes; Mental State Examination as expected in relation to their level of education 13 points for illiterate 18 points for low/medium education and 26 points for high education	Presence of contraindications for Transcutaneous Auricular Vagus Nerve Stimulation (metal cochlear implant at the site of application); history of stroke; Coronary disease chronic obstructive or restrictive pulmonary; disease peripheral arterial disease hypo- or hypernatremia; hyper- or hypothyroidism; chronic atrial fibrillation; Diabetes Mellitus immune-dependent kidney disease chronicle	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-5wnvtpk	Impact of bacterial vaginosis screening on the prevention of premature rupture of the amniotic sac and preterm birth in high-risk pregnancies	Not yet recruiting	Intervention	2024-11-27	<NULL>	<NULL>	7542	Impact of bacterial vaginosis screening on the prevention of premature rupture of membranes (PROM) and preterm birth (PTB) in high-risk pregnancies: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Faculdade de Medicina da Universidade Federal Fluminense	Faculdade de Medicina da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-5wnvtpk	<NULL>	Pregnant women with less than 20 weeks of gestation; no age limit; with one or more risk factors for preterm birth or premature rupture of membranes, such as a previous history of preterm birth or premature rupture of membranes; cervical insufficiency; multifetal pregnancy; young maternal age; advanced maternal age; maternal Body Mass Index below 20; chronic or gestational diabetes; chronic or gestational hypertension	Inability to understand and sign the Informed Consent Form; presence of clinical signs of bacterial vaginosis, such as abnormal discharge; allergy to metronidazole	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-10bhfy8q	Effect of the association of Dexamethasone with Prednisolone on anesthetic success, Postoperative Pain and Quality of Life after Root Canal Treatment in patients with Preoperative Pain	Recruiting	Intervention	2024-11-26	<NULL>	<NULL>	7539	Effectiveness of Oral and Supraperiosteal Premedication with Prednisolone and Dexamethasone on anesthetic success, Postoperative Pain reduction and Quality of Life After Endodontic Treatment in patients with Preoperative Pain	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal de Campina Grande	Universidade Federal de Campina Grande	https://ensaiosclinicos.gov.br/rg/RBR-10bhfy8q	<NULL>	Systemically healthy patients; of any gender aged; between 18 and 65 years; teeth diagnosed with symptomatic or asymptomatic irreversible pulpitis; symptomatic apical periodontitis (presence of preoperative pain); and preoperative pain ranging from level to severe on the Heft-Parker visual analogue scale	pregnant or breastfeeding women; patients with allergies, sensitivity or adverse reactions to Dexamethasone or Ibuprofen; individuals who received any analgesic or anti-inflammatory in the last 12 hours before treatment; and non-restorable teeth, with periodontal disease, root resorption, open apex and calcified root canals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-9yk239p	ORC-128436_EN24-0540-02_Skin Evaluation of Potential to Cause Irritation or Sensitivity When Exposed to Light	Not yet recruiting	Intervention	2024-11-25	<NULL>	<NULL>	7535	ORC-128436_EN24-0540-02_Dermatological Evaluation of Topical Photoirritant and Photosensitizing Potential	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Medcin Instituto da Pele LTDA	Medcin Instituto da Pele LTDA	https://ensaiosclinicos.gov.br/rg/RBR-9yk239p	<NULL>	Participants must be of both genders; aged between 18 and 70; have Fitzpatrick skin type II or III; intact skin in the product application area. They must agree to follow all study procedures; attend the Center on specified days and times for medical evaluations, applications, and patch readings; sign the Informed Consent Form (ICF), demonstrating full understanding and acceptance of the study conditions	Pregnancy or risk of pregnancy/lactation; use of anti-inflammatory drugs in the last 30 days and/or immunosuppressive drugs up to three months before selection; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the evaluation or during the study period; anticipated sea bathing, pool use, or sauna sessions during the study; practice of aquatic sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to one month before the start of the study; aesthetic and/or dermatological treatment on the body within three weeks before selection; scheduled vaccination during the study period or up to three weeks before selection; history of sensitization, irritation, or photosensitization to topical products; active skin conditions (local and/or widespread) that could interfere with study results; skin reactivity; use of new medications during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or drug abuse; known history or suspected intolerance to any ingredient in the study product; history of non-adherence or unwillingness to follow the study protocol; previous history of conditions worsened or triggered by ultraviolet radiation; use of photosensitizing drugs; history or activity of photodermatoses; personal or family history of skin cancer; presence of precursor lesions for skin neoplasia, such as melanocytic nevi and actinic keratosis; use of new medications during the study; other conditions considered by the researcher as reasonable for disqualification from study participation, which must be described as a note in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-6rj3wkt	Mobile app to help bronchiectasis patients take care of their health	Recruiting	Intervention	2024-11-25	<NULL>	<NULL>	7536	Development of an Application for use on phones (cell phones) for self-management and self-efficacy in patients with Bronchiectasis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-08	Hospital de Clínicas da UNICAMP	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6rj3wkt	<NULL>	Men or women; over the age of 18 will be included; a diagnosis of bronchiectasis not associated with cystic fibrosis confirmed by high-resolution chest CT (HRCT); not having used systemic corticosteroids or antibiotics in the 4 weeks prior to inclusion; have had at least one exacerbation that required antibiotics in the last 12 months prior to inclusion; have a cell phone that allows the installation and use of the application; be familiar with the use of cell phone applications, or have access to a family member or caregiver who does	Patients with a diagnosis of cystic fibrosis, or bronchiectasis characterized as traction bronchiectasis on HRCT; cognitive deficits or inability to understand the guidelines for using the tool that will be used in the research; severe or decompensated comorbidity (renal failure, severe heart failure, active cancer/treatment, severe immunosuppression); desire not to participate in the study, or failure to sign the informed consent form (ICF) will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-5sfqt7n	ORC-128436_EN24-0540-01_02_Evaluation of Skin Irritation and allergies	Not yet recruiting	Intervention	2024-11-25	<NULL>	<NULL>	7537	ORC-128436_EN24-0540-01_02_Primary Skin Irritability Evaluation, Irritability (HRIPT)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-25	Medcin Instituto da Pele LTDA	Medcin Instituto da Pele LTDA	https://ensaiosclinicos.gov.br/rg/RBR-5sfqt7n	<NULL>	Participants of both sexes aged 18 to 70 years. Phototype I, II, III, and IV according to the Fitzpatrick scale. Intact skin in the application area. Agreement to follow the trial procedures; attendance at the Center on the specified days and times for medical evaluations, applications, and patch readings. Understanding, consent, and signing of the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy/lactation. Use of anti-inflammatory drugs in the last 30 days and/or immunosuppressive drugs up to three months before selection. Immunosuppression due to drugs or active diseases. Uncompensated endocrinopathies. Personal history of atopy. Intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period. Planned exposure to sea baths, swimming pools, or saunas during the study. Practice of water sports during the study. Dermatographism. Use of oral or topical treatment with vitamin A acid and/or derivatives up to 1 month before the study start. Aesthetic and/or dermatological treatment on the body within 3 weeks prior to selection. Scheduled vaccination during the study period or up to 3 weeks before selection. History of sensitization, irritation, or photosensitization to topical products. Active skin conditions (local and/or widespread) that may interfere with the study results. Skin reactivity. Use of new medications during the study. Previous participation in studies with the same product. Congenital or acquired immunodeficiency. Relevant clinical history or current evidence of alcohol or other drug abuse. Known or suspected history of intolerance to any ingredient of the study product. History of non-adherence or unwillingness to adhere to the study protocol. Medcin employees or sponsor company employees involved in the study or immediate family members of an employee involved in the study. Other conditions considered reasonable by the researcher for disqualification from study participation being described in the observation section of the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-399jydc	Rare care:reationship between social, nutritional and clinical aspects in Angelman syndrome	Recruiting	Observational	2024-11-25	<NULL>	<NULL>	7538	Rare care: interrelationships between social determinants, nutritional status and clinical aspects in Angelman syndrome	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal do Rio de Janeiro	Instituto de Nutrição Josué de Castro da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-399jydc	<NULL>	Family members and/or primary caregivers of people with a positive genetic diagnosis for Angelman Syndrome; both sexes; aged between one day and 60 years; resident of Brazil; agreed with the Informed Consent Form	Non-resident Brazilians; presence of comorbidity not related to the syndrome; prematurity; disagree with the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-79pss6w	Effect of Water with Ozone in the treatment of Pericoronitis	Not yet recruiting	Intervention	2024-11-22	<NULL>	<NULL>	7532	Effect of Ozonated Water as an adjunct in the treatment of Pericoronitis: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Federal dos Vales do Jequitinhonha e MucurI	Universidade Federal dos Vales do Jequitinhonha e MucurI	https://ensaiosclinicos.gov.br/rg/RBR-79pss6w	<NULL>	Participants with signs/symptoms of pericoronaritis, such as the occurrence of spontaneous pain, erythema, purulent or draining edema, affecting the gingiva of the oral cavity, located over the lower third molar; age 18 to 35 years; both sexes; surgical risk level I and level II, according to the American Society of Anesthesiologists (ASA I and ASA II); periodontal status level I and II, according to the American Academy of Periodontology; consent to participate in this clinical trial by signing the Informed Consent Form (ICF)	Participants with surgical risk level III and level IV, according to the American Society of Anesthesiologists (ASA III and ASA IV); with periodontal status level IV, according to the American Academy of Periodontology; undergoing antibiotic therapy in the last two months; with any medical contraindication for periodontal probing; currently using tobacco and aged less than 18 years and more than 35 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-9q35d6n	Clinical longevity of impression-made composite resin restorations and out-of-mouth restorations in destroyed teeth: a clinical study	Not yet recruiting	Intervention	2024-11-22	<NULL>	<NULL>	7533	Clinical longevity of composite resin restorations obtained by 3D printing and semi-direct restorations in extensively destroyed teeth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-30	Universidade Federal de Pelotas - Faculdade de Odontologia	Universidade Federal de Pelotas - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-9q35d6n	<NULL>	Indicate extensive restoration in posterior teeth (molar and premolar); be in good general health to undergo dental treatment; and; agree to participate in the study by signing an informed consent form; both sexes	Patients who do not have at least 12 posterior teeth in occlusion; patients who are undergoing orthodontic treatment or planning to undergo orthodontic treatment; patients with a systemic disease that prevents dental treatment; patients not available for follow-up appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-372zgsp	Root Canal Treatment versus Partial Pulp Removal in teeth with formed roots and Symptomatic Irriversible Pulpitis	Recruiting	Intervention	2024-11-21	<NULL>	<NULL>	7527	Pulpotomy versus Endodontic Treatment in teeth diagnosed with Symptomatic Irreversible Pulpitis and complete rhizogenesis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-13	Faculdade de Odontologia de Piracicaba-Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba-Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-372zgsp	<NULL>	Patients aged 18 years and over; both genders; with a permanent tooth with complete rhizogenesis with deep cavities/restorations and symptoms indicative of irreversible symptomatic pulpitis (moderate to severe persistent spontaneous pain); the tooth must respond to the sensitivity to cold and electrical testing; must be restorable and can be rubber dam isolated adequately	Teeth with active periodontal disease (pocket depth &gt;5mm); teeth indicated for elective endodontic treatment for restorative purposes; teeth with apical periodontitis; systemically compromised patients or who have undergone radiotherapy; patients unable to consent; history of trauma to the tooth; pregnant or postpartum patients; teeth with any evidence of purulence or excessive bleeding that cannot be controlled with a cotton ball with 2.5% sodium hypochlorite for 10 minutes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-498fr3w	Vestibular Rehabilitation and Galvanic Vestibular Stimulation in children with Spastic Cerebral Palsy	Recruiting	Intervention	2024-11-21	<NULL>	<NULL>	7528	Vestibular Rehabilitation and Galvanic Vestibular Stimulation in children with Spastic Cerebral Palsy: clinical, crossover, placebo-controlled, double-blind trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-26	Irmandade da Santa Casa de Misericórdia de São Paulo	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-498fr3w	<NULL>	Diagnosis of Spastic Cerebral Palsy; have magnetic resonance imaging demonstrating damage to the pyramidal system, without involvement of the extrapyramidal system and cerebellum; functionally classified as levels I, II or III by the Gross Motor Function Classification System (GMFCS); degree of spasticity less than three on the Modified Ashworth Scale; able to walk independently for at least 12 months, even if requiring walking aids; aged between six and twelve years; both sexes; degrees of understanding and collaboration compatible with carrying out the proposed activities; guardians agreed to their participation in the study by signing the Free and Informed Consent Form; participant acceptance through the assent form	Children have neurological, neuromuscular diseases or syndromes associated with Cerebral Palsy - CP; children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-104qgt7b	The offer of Yacon Syrup to overweight and obese women with Polycystic Ovary Syndrome and glycemic control	Data analysis completed	Intervention	2024-11-21	<NULL>	<NULL>	7529	Offering Yacon Syrup to women with Polycystic Ovary Syndrome, and overweight/obesity: impacts on postprandial glycemia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-24	Centro de Saúde Escola da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Centro de Saúde Escola da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-104qgt7b	<NULL>	Women; in reproductive age between 18 and 40 years; with Body Mass Index (BMI) indicating overweight, obesity I, and 2 (greater than or equal to 25 kg/m²  or lower than or equal to 39,9 kg/m²)	Women who are smokers; alcoholics; pregnant or breastfeeding; volunteers diagnosed with kidney, liver, or thyroid diseases, diabetes mellitus, Cushing syndrome, ovarian insufficiency, presence of ovarian or uterine tumors, congenital adrenal hyperplasia; or those who did not comply with all the protocols established for the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-7tybqpq	Neuromodulação do córtex pré-frontal por rTMS e treinamento neurofuncional em crianças com transtorno do espectro autista	Recruiting	Intervention	2024-11-21	<NULL>	<NULL>	7531	Neuromodulation of the pré-frontal cortex using rTMS and neurofunctional training in children with autism spectrum disorder: a double-blind, randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-10	Universidade Evangélica de Goiás	Follow Kids - Clinica de Neuro Reabilitação Infantil	https://ensaiosclinicos.gov.br/rg/RBR-7tybqpq	<NULL>	Diagnosis of autism spectrum disorder confirmed through clinical examination; have a standardized neurobehavioral assessment that confirms and categorizes the severity of autism spectrum disorder; children levels I, II and III according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V); age between three and eight years of age of both sexes; children who demonstrate sufficient response to understand simple verbal commands; no medication changes at least six months before the start of the study and during its execution; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-946n2cb	The effect of use of Low Concentration Bleaching gels associated with a Violet LED: randomized double-blind clinical study	Recruitment completed	Intervention	2024-11-19	<NULL>	<NULL>	7525	Effect of use of 6% Hydrogen peroxide gel associated with Violet LED: randomized double-blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-15	Faculdade de Odontologia da Universidade de São Paulo	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-946n2cb	<NULL>	Participants must be in good general and oral health; both canines have to be A2 color or more saturated; both sexes	Pregnant or lactating women; use of medications that may cause photosensitization of the skin; presence of severe tooth discoloration (e.g. tetracycline, fluorosis, etc.); exacerbated dentin sensitivity; presence of carious lesions or previous restorations, crowns, veneers and endodontic treatment on upper and lower anterior teeth; teeth whitening treatment carried out less than 3 years ago	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-9s776cs	Analysis of quality of life related to the condition of the gums and bone around the teeth and associated risk factors of pregnant women treated at basic health units	Recruiting	Observational	2024-11-19	<NULL>	<NULL>	8118	Analysis of quality of life related to periodontal condition and associated risk factors of pregnant women treated at basic health units	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-24	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9s776cs	<NULL>	Pregnant women in the 3rd trimester of pregnancy; between 18 and 40 years of age; regular follow-up with the obstetrician; diagnosis of Gestational Diabetes Mellitus, Arterial Hypertension/Pre-eclampsia, Obesity or association between such factors (for the high-risk pregnancy group) and without any systemic impairment (for the normal-risk pregnancy group); adequate cognitive and neuromotor behavior; adequate ability to perform regular oral hygiene	Need for complete rest for any medical reason; using, or having used at any time during pregnancy, antibiotics or any medication that may interfere with periodontal conditions; multiple tooth loss (more than two teeth per hemiarch); tooth loss prior to pregnancy due to periodontitis; undergoing orthodontic, periodontal or any dental treatment with another dentist; having previously undergone surgical periodontal treatment; pre-gestational depression; Diabetes Mellitus and High Blood Pressure prior to pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-64jx632	Assessment of skin irritation after use of a medical device	Not yet recruiting	Intervention	2024-11-18	<NULL>	<NULL>	7519	ORC-131878_EN24-0608-01_Evaluation of primary skin irritability, cumulative skin irritability and skin sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-02	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-64jx632	<NULL>	Participants of both sexes; aged 18 to 70 years; phototype: I, II, III and IV; intact skin in the application region; agreement to follow the trial procedures and to attend the Center on the days and times determined for medical evaluations and for application and reading of dressings; understanding, consenting to and signing the Free and Informed Consent Form	Pregnancy or risk of pregnancy/lactation; use of anti-inflammatory drugs 30 days and/or immunosuppressive drugs for up to three months prior to selection; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days prior to the assessment or during the study period; anticipated sea bathing, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 month prior to the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks prior to selection; scheduled vaccination during the study period or up to 03 weeks prior to selection; history of sensitization, irritation or photosensitization to medical devices; active skin pathologies that may interfere with the results of the study; skin reactivity; use of new medications during the study; previous participation in studies with the same physician; congenital or acquired immunodeficiency; relevant clinical history or current evidence of alcohol or other drug abuse; known history or suspected intolerance to any ingredient of the study medical device; history of non-adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-547cnx9	Test with patients seeking to demonstrate the efficacy of Hycos MG500 I in assisting skin regeneration	Recruiting	Intervention	2024-11-18	<NULL>	<NULL>	7520	Clinical study, single-blind, of the efficacy and safety of the product Hycos MG500 I	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Nipo Serviços Médicos SS Ltda	Instituto de Saúde e Bem Estar da Mulher	https://ensaiosclinicos.gov.br/rg/RBR-547cnx9	<NULL>	The participating patient has a wound, lesion, or bedsore. The injury requires dressings. Age between 18 and 90 years old. Any ethnicity, color/race, and skin phototype. Both genders. Patients are in the early stages of treatment	Pregnancy. Neonates. Sensitivity to the components of the medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-74kf6vm	Test with patients seeking to demonstrate the efficacy and safety of Hycos MG 500 in chronic or acute wounds	Recruiting	Intervention	2024-11-18	<NULL>	<NULL>	7521	Clinical study, single-blind, of the efficacy and safety of the product Hycos MG 500	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Nipo Serviços Médicos SS Ltda	Instituto de Saúde e Bem Estar da Mulher	https://ensaiosclinicos.gov.br/rg/RBR-74kf6vm	<NULL>	The participating patient has a wound, lesion, or bedsore. The injury requires dressings. Age between 18 and 90 years old. Any ethnicity, color/race, and skin phototype. Both genders. Patients are in the early stages of treatment	Pregnancy. Neonates. Sensitivity to the components of the medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-7kc6rrx	Tests are being conducted to verify if the product Hycos Reparador EB is effective and safe for people with Epidermolysis Bullosa (EB)	Recruitment completed	Intervention	2024-11-18	<NULL>	<NULL>	7522	Single-blind clinical study of the efficacy and safety of the product Hycos Reparador EB	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-11	Instituto de Saúde e Bem Estar da Mulher	Nipo Serviços Médicos SS Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7kc6rrx	<NULL>	Patients of both sexes. Age over 12 months. All skin types	Pregnancy and/or lactation. Immunodeficiency. Use of systemic corticosteroids. History of reaction to the category of the product tested. Other diseases or medications that may directly interfere with the study or pose a risk to the volunteer&apos;s health	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-9zrckqx	Patient test to prove the efficacy and safety of the product Debriderm Fluid, a liquid solution intended for wound dressing preparation	Recruitment completed	Intervention	2024-11-18	<NULL>	<NULL>	7523	Single-blind clinical study on the efficacy and safety of the product Debriderm Fluid	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-11	Instituto de Saúde e Bem Estar da Mulher	Nipo Serviços Médicos SS Ltda	https://ensaiosclinicos.gov.br/rg/RBR-9zrckqx	<NULL>	The participating patient has a wound, lesion, or ulcer. The injury requires dressings. Age between 18 and 90 years. Any ethnicity, color/race, and skin phototype. Both genders. Patients are in the early stages of treatment	Pregnancy. Neonates. Sensitivity to the medication components	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-10zb5s89	Patient trial to verify if Diabetran helps treat wounds, protect injured skin, and ease bandage application	Recruitment completed	Intervention	2024-11-18	<NULL>	<NULL>	7524	Single-blind clinical study on the efficacy and safety of the product Diabetran	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-20	Nipo Serviços Médicos SS Ltda	Instituto de Saúde e Bem Estar da Mulher	https://ensaiosclinicos.gov.br/rg/RBR-10zb5s89	<NULL>	The participating patient has a wound, lesion, or bedsore. The injury requires dressings. Age between 18 and 90 years old. Any ethnicity, color/race, and skin phototype. Both genders. Patients are in the early stages of treatment	Pregnancy. Neonates. Sensitivity to the components of the medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-3cvzhkn	Study comparing the effects of volume versus flow Respiratory Incentives in the postoperative period of bariatric surgery	Recruitment completed	Intervention	2024-11-17	<NULL>	<NULL>	7518	Comparative study of the effects of volume versus flow Incentive Spirometry in the postoperative period of bariatric surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Centro Hospitalar Valinhos e Vinhedo - Serviços Medicos S/S	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3cvzhkn	<NULL>	Individuals over 18 years of age and under 60 years of age; patients undergoing bariatric surgery by videolaparoscopy and endoscopic; normal preoperative pulmonary function test; patients without radiological alterations in the preoperative period; non-smokers; patients without previous pulmonary impairment such as asthma; bronchitis; emphysema, signature of the Free and Informed Consent Form by the patient	Hemodynamic instability (MAP &lt; 60mmHg) during surgery; conversion from laparoscopy to laparotomy; adjustment of ventilatory parameters during surgery; patient&apos;s refusal to perform the requested exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-8hhw3s2	The effects of Auriculotherapy in the stress of physiotherapy students	Data analysis completed	Intervention	2024-11-14	<NULL>	<NULL>	7513	Early and late effects of Auricular Acupunture on students with Burnout Syndrome in the physiotherapy course at UFPR	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-19	Curso de Fisioterapia da Universidade Federal do Paraná	Setor de Ciências da Saúde da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8hhw3s2	<NULL>	Individuals between 18 and 25 years old; of both sexes; students actively enrolled in the Physiotheraphy course at the Universade Federal do Paraná	Lack of integrity of the ear; non-acceptance of voluntarily participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-3tq63qk	Use of Radiofrequency Energy in the vulvovaginal region for the treatment of women with Urogenital symptoms present in Menopause and who have previously undergone radiotherapy	Data analysis completed	Intervention	2024-11-14	<NULL>	<NULL>	7514	Evaluation of the use of vulvovaginal Microablative Fractional Radiofrequency (MAFRF) in women with Genitourinary Syndrome of Menopause and previously submitted to pelvic radiotherapy and or brachytherapy	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2017-08-17	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3tq63qk	<NULL>	Menopausal patients who had undergone pelvic radiotherapy or brachytherapy, complaining of menopausal urogenital syndrome; Pap smear test negative for neoplasia, within the routine deadline recommended by the Ministry of Health/INCA; without active genital hormone therapy	Use of estrogenic and or androgenic hormone therapy in the last sixty days; adverse anatomical conditions; users of pacemakers or internal defibrillators or any other active electrical implant; permanent implant in the treated area, such as polypropylene meshes; severe decompensated clinical conditions (such as cardiac dysfunctions; active systemic collagenoses; confirmed or presumed immunodeficiencies)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-5j3sfxq	Telerehabilitation program: a comparative study with patients suffering from stroke	Recruiting	Intervention	2024-11-14	<NULL>	<NULL>	7515	Multidisciplinary telerehabilitation program: a comparative study with patients with sequelares of cerebral stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Instituto de Medicina Integral Professor Fernando Figueira	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-5j3sfxq	<NULL>	Patients of both sexes; over 18 years old; diagnostic of ischemic or hemorrhagic stroke	Patients with heart disease; tracheostomized; aphasic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-94tnw6s	How Radiofrequency helps rejuvenate the eye area: study proven in women	Recruitment completed	Intervention	2024-11-14	<NULL>	<NULL>	7516	Evaluation of the effects of Fractional Radiofrequency on lower eyelid skin sagging: a prospective study	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Faculdade de Medicina de Botucatu-FMB- Universidade Estadual Paulista-UNESP	Faculdade de Medicina de Botucatu-FMB- Universidade Estadual Paulista-UNESP	https://ensaiosclinicos.gov.br/rg/RBR-94tnw6s	<NULL>	Patients over 18 years of age; without distinction of sex; which shows signs of aging and sagging of the periorbital skin; presence of rhytids; Fitzpatrick phototypes I to IV	Patients with Fitzpatrick skin types V and VI; Asian or Black phenotypes; those with melasma; collagen diseases; impaired wound healing (diabetics, smokers); with active infection at the application site; coagulopathies; skin cancer; immunosuppressive diseases; lactating or pregnant women; those with pacemakers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-8xtsgvv	Evaluation of Metabolic and Cardiovascular Risk markers in transgender men using Testosterone	Not yet recruiting	Observational	2024-11-14	<NULL>	<NULL>	7517	Evaluation of Metabolic, Inflammatory, Cardiovascular and Endothelial Risk markers in transgender men on Testosterone therapy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-15	Universidade Federal de São Paulo - Escola Paulista de Medicina	Centro de Referência e Treinamento DST/AIDS-SP	https://ensaiosclinicos.gov.br/rg/RBR-8xtsgvv	<NULL>	Transgender men; 18 to 59 years old; no previous hormone therapy; or hormone therapy stopped at least 6 months before the begining of the study; willing to start testosterone therapy	Not being able to understand the protocol rules; not being able to attend the institution for the scheduled visits and laboratory exams	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-466cykz	Use of Surgical Laser in the treatment of Tongue Tie in children: randomized, triple blind and controlled clinical trial	Recruiting	Intervention	2024-11-13	<NULL>	<NULL>	7508	Use of High Power Diode Laser in the surgical treatment of Ankyloglossia in pediatric patients: randomized, triple blind and controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-22	Instituto para o Desenvolvimento da Educação Ltda-IPADE/Faculdade	Centro Universitário Christus	https://ensaiosclinicos.gov.br/rg/RBR-466cykz	<NULL>	Healthy individuals between 0 and 12 years; old male or female; diagnosed with ankyloglossia by a dental surgeon pediatric dentist using the Bristol Tongue Assessment Tool Protocol	Individuals with systemic impairments that contraindicate the surgical procedure such as blood dyscrasias; hemophilia; nutritional deficiency; immunodeficiency; neurological or neuromuscular disorders; undergoing previous pharmacological treatment; with breastfeeding difficulties but without a diagnosis of ankyloglossia; with absolute or relative contraindications to the administration of local anesthetics; with orofacial congenital malformations weight loss greater than 10% of birth weight whose guardians refuse to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-3bgyznp	Oral irrigators and the protection of dental implants: results from a study on oral hygiene and patient health	Not yet recruiting	Observational	2024-11-13	<NULL>	<NULL>	7509	Effect of the adjunctive use of oral irrigators on the Peri-Implant Condition in individuals under Maintenance Therapy: prospective study on clinical, microbiological, and immunological aspects	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-12-15	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3bgyznp	<NULL>	Patients of both genders; non-smokers or former smokers; non-diabetic; absence of other systemic diseases that would impede periodontal and peri-implant clinical examination; no continuous use of systemic antimicrobials or anti-inflammatory medications in the two months before periodontal and peri-implant examinations; dentate individuals with fixed prosthetic rehabilitations on implants	Participants with inadequate adherence to the use of interdental brushes or oral irrigators; individuals who developed diabetes during the study; individuals under continuous use of corticosteroids; individuals who resumed smoking; participants with irregular attendance at periodontal and peri-implant maintenance therapy appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-34mx8kc	Impact of moving and static stretching on jumping in adolescent volleyball athletes	Recruitment completed	Intervention	2024-11-13	<NULL>	<NULL>	7510	The acute effect of dynamic and static stretching on vertical jump in adolescent volleyball athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-34mx8kc	<NULL>	the project foresees the participation of 20 healthy athletes; the base category of volleyball; from the Itajaí valley region in Santa Catarina; present a body mass index greater than 18 kg/m2 and less than 25 kg/m2; categorized as normal according to World Health Organization criteria; be between 12 and 18 years old; male; have been training volleyball for at least 1 year; frequency of this training at least three times a week; with these training sessions lasting at least one hour daily; no signs of local pain complaints	the project does not provide for athletes who are unhealthy; be under 12 years old; over 18 years old; athletes who have a body mass index categorized below or above normal weight, which is between 18 Kg/m2 and 25 Kg/m2 according to the criteria of the World Health Organization; have musculoskeletal diseases; history of injuries or surgeries in the last 90 days in the lower limbs; changes in the balance system (vestibular) in the last 30 days; use of controlled medication; previous physiotherapeutic treatment in the last 30 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-8j855ry	Impact of Minimally Invasive Root Canal Treatment on Microbial Reduction, Postoperative Pain, and Regression of Endodontic Lesions in Lower Molars: A Randomized Controlled Clinical Study	Recruiting	Intervention	2024-11-13	<NULL>	<NULL>	7511	Impact of Minimally Invasive Protocols on the Reduction of Intracanal Bacteria and Endotoxins, Postoperative Pain, and Periradicular Lesion Regression in Mandibular Molars: A Randomized Controlled Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade do Estado do Rio de Janeiro - Faculdade de Odontologia	Universidade do Grande Rio	https://ensaiosclinicos.gov.br/rg/RBR-8j855ry	<NULL>	Healthy male or female patients between 18 and 60 years of age;  with a lower molar presenting necrotic pulp and periradicular lesion, without prior endodontic treatment	Patients who have used analgesics in the past 12 hours or antibiotics in the past month; pregnant women; smokers; diabetics; those with an acute periapical abscess; periodontal pockets greater than 5mm; mobility greater than grade I; alveolar bone loss exceeding 50%; incomplete apices; teeth with calcifications and resorptions; and non-restorable teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-8r5c2qv	Effectiveness of physiotherapist performance on the functionality of workers using computer terminals: randomized clinical trial	Recruitment completed	Intervention	2024-11-13	<NULL>	<NULL>	7512	Effectiveness of physiotherapeutic intervention on the functionality of workers using computer terminals: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-07	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8r5c2qv	<NULL>	Individuals aged 18 or over; who work at the State Secretariat for Administration using the computer; with a workload of more than 4 hours per day; who agree to participate in the research by signing the Informed Consent Form; and also participate in the physiotherapeutic intervention for three months, ensuring adherence to treatment	Participants who do not adhere to the proposed interventions, considering the maximum percentage of absences of 30% of the proposed physiotherapeutic intervention; those who are terminated, removed, go on vacation or leave, during the carrying out of this study and the worker who does not present medical certificate; workers who have a diagnosed serious illness;  who use medication regularly; are practicing other physical activity (gym, sports, dancing, running, walking, gymnastics) and/or carrying out physiotherapeutic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-3s6fk6j	Effect of electrical stimulation applied to the left ear associated with physical training on a bicycle in people with high blood pressure	Not yet recruiting	Intervention	2024-11-12	<NULL>	<NULL>	7506	Effects of Noninvasive Vagus Nerve Stimulation and Aerobic Exercise on Blood Pressure, Cardiac Autonomic Modulation, Inflammation and Functional Capacity in Hypertensive Patients: a controlled, randomized, blinded clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Associação Educacional Nove de Julho	Associação Educacional Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-3s6fk6j	<NULL>	Individuals of both genders diagnosed with mild to moderate hypertension (Stages I and II); over 18 years of age; who use a maximum of 3 classes of drugs; hypertensive individuals with systolic blood pressure (SBP) levels of 140 to 160 mmHg and diastolic blood pressure (DBP) of 90 to 100 mmHg; hypertensive individuals physically fit to perform exercises and with medical clearance for the activity	Individuals with contraindications for the use of vagus nerve stimulation (cochlear implant, metals or skin lesions at the application site); Individuals with a history of ischemic stroke, coronary disease, chronic obstructive or restrictive pulmonary disease, peripheral arterial disease, hyper or hypothyroidism, chronic atrial fibrillation, Diabetes Mellitus, immunodependent, chronic kidney disease on dialysis; Individuals using antihypertensives (beta blockers); pregnant women; Individuals with cardiac pacemakers; Individuals who do not complete all training and who do not perform post-intervention evaluations will be excluded from the final analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-97vxqpr	Neuromodulation combined with other neurotechnology and the evaluation of the somatosensory functionality	Recruiting	Intervention	2024-11-12	<NULL>	<NULL>	7507	Neuromodulation combined with other neurotechnology and the evaluation of the somatosensory functionality in neurological patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-15	Instituto de Física Gleb Wataghin	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-97vxqpr	<NULL>	Participants both sex. Participants with lower limb spasticity of the affected side. Participants who are over 18 years old. Participants who are able to perform activities of daily living such as sit-to-stand without the need of external support. Participants who have low ankle mobility from the same limb. Participants also should be free of any musculoskeletal injury. Female and male participants will be recruited for the study	Participants who have suffered stroke less than 6 months. Participants who have had any local surgery. Epilepsy. Mental implant on the skull. Participants who utilise any auditive dispositive	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-9pvbx34	Laser Auriculotherapy for management of neuropsychological symptoms in patients with gastrointestinal Cancer	Recruiting	Intervention	2024-11-12	<NULL>	<NULL>	8036	Effect of Laser Auriculotherapy on the management of cluster of neuropsychological symptoms in patients with gastrointestinal Neoplasms: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-20	Programa de Pós-Graduação em Enfermagem - Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9pvbx34	<NULL>	Patients of both sexes and any gender; aged at least 18 years; with gastrointestinal cancer; who will begin treatment with chemotherapy	Patients who have a disorder that makes it impossible to understand and participate in the research; patients who already use the complementary therapy used in the study; patients who have an infectious process or lesion in the ear; refusal to receive laser ear treatment; patients with disease recurrence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-9tmdkh4	Effects of a heart training protocol associated with LED light therapy on signs and symptoms, performance and functionality of people with diabetes and nerve involvement	Recruiting	Intervention	2024-11-11	<NULL>	<NULL>	7497	Effects of a Cardiovascular Rehabilitation Protocol associated with Photobiomodulation on signs and symptoms, performance and functionality of individuals with Diabetic Neuropathy – a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-05	Departamento de Fisioterapia - Universidade Federal do Ceará	Hospital Universitário Walter Cantídio	https://ensaiosclinicos.gov.br/rg/RBR-9tmdkh4	<NULL>	Individuals aged 18 years or older; both sexes; who have a diagnosis of Diabetes Mellitus (type 1 or type 2) confirmed by a doctor (fasting plasma glucose higher or equal 126mg/dl and/or glycated hemoglobin higher or equal 6.5%); presence of diabetic peripheral neuropathy confirmed in the evaluation	Individuals with neuropathy of other etiologies; severe chronic kidney disease; severe diabetic retinopathy; presence of unhealed ulcers in the lower limbs; pregnant women or those intending to become pregnant; and individuals with contraindications for performing physical exercises or with performance limitations that make it impossible to conduct the assessment and training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-9fcpncq	ORC_128436_EN24-0540-03_Analysis of the Acceptance and Perceived Effectiveness of a Product for Maintaining Intimate pH	Not yet recruiting	Intervention	2024-11-11	<NULL>	<NULL>	7498	ORC_128436_EN24-0540-03_Gynecological Acceptability Assessment and pH Maintenance with Perceived Efficacy	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2025-01-09	Medcin Instituto da Pele LTDA	Medcin Instituto da Pele LTDA	https://ensaiosclinicos.gov.br/rg/RBR-9fcpncq	<NULL>	Female population; female participants aged 18 to 60 years; participants with an active sex life; participants with a pH value between 3.8 and 4.5; heterosexual couples through stable union or civil marriage; intact skin in the area of analysis of the product (vaginal mucosa); must be users of products in the same category; agreement to follow the study procedures and attend the Clinical Research Center on the specified days and times for evaluations; understanding, consent, and signing of the Informed Consent Form (ICF); male population; male participants aged 18 to 60 years; heterosexual couples through stable union or civil marriage; intact skin in the area of analysis of the product (penile region); must be users of products in the same category; agreement to follow the study procedures and attend the Clinical Research Center on the specified days and times for evaluations; understanding, consent, and signing of the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy and/or lactation (for women); sexually transmitted infections, such as candidiasis, trichomoniasis, or conditions that compromise the safety evaluation of the product; use of anti-inflammatory drugs, immunosuppressants, or antihistamines up to 3 weeks before selection; skin markings in the experimental area that interfere with the evaluation of possible skin reactions, such as vascular malformations, scars, increased hair growth, numerous nevi, or sunburns; atopic or allergic history to products in the same category; active skin pathologies or lesions (local or disseminated) in the evaluation area; immunosuppression due to drugs or active diseases; decompensated endocrinopathies; relevant clinical history or current evidence of alcohol or drug abuse; known or suspected intolerance to products in the same category; intense sun exposure up to 15 days before evaluation; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; other conditions deemed reasonable by the investigator for disqualification from participation in the study, which should be described in the clinical record observation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-98vwvvy	EN23-0216-01 Skin Reaction and Sensitivity Test for a Product	Not yet recruiting	Intervention	2024-11-11	<NULL>	<NULL>	7499	EN23-0216-01 Evaluation of Primary Dermal Irritability, Cumulative Dermal Irritability, and Dermal Sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-27	Medcin Instituto da Pele LTDA	Medcin Instituto da Pele LTDA	https://ensaiosclinicos.gov.br/rg/RBR-98vwvvy	<NULL>	Participants of both sexes aged 18 to 70 years; skin Phototype: I, II, III, and IV (according to the adapted Fitzpatrick scale); intact skin in the application area; agreement to follow the trial procedures and attend the clinic on the specified days and times for medical evaluations and for the application and reading of dressings; understanding, consenting to, and signing the Informed Consent Form (ICF)	Pregnancy or risk of pregnancy and/or lactation (for women); use of anti-inflammatory drugs within 30 days and/or immunosuppressive drugs up to three months prior to selection; immunosuppression due to drugs or active diseases; uncontrolled endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before evaluation or during the study period; planned intense sun exposure or tanning sessions during the study period; planned sea bathing, swimming, or sauna use during the study; participation in water sports during the study; dermographism; use of oral or topical vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 3 weeks prior to selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization, irritation, or photosensitization to topical products; active skin conditions (local and/or widespread) that could interfere with study results; skin reactivity; use of new medications/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant clinical history or current evidence of alcohol or other drug abuse; known history or suspected intolerance to any ingredient of the study products (test or comparator products); history of non-compliance or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable grounds for disqualification from the study; if so, this should be noted in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-7xpkjhk	Clinical evaluation of the use of Lasers and LEDs for facial rejuvenation	Recruitment completed	Intervention	2024-11-11	<NULL>	<NULL>	7501	Effect of low-intensity light sources on improving skin quality: randomized, controlled, blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Faculdade de Odontologia da Universidade de São Paulo (Fousp)	Faculdade de Odontologia da Universidade de São Paulo (Fousp)	https://ensaiosclinicos.gov.br/rg/RBR-7xpkjhk	<NULL>	Female patients; aged between 35 and 70 years; and presenting type II and III expression lines on the Glogau scale	Pregnant patients; who have dermatitis; or skin neoplasms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-4r37q7z	Study to prevent Anemia in children under one year old in Nampula, Mozambique	Recruitment completed	Intervention	2024-11-11	<NULL>	<NULL>	7502	Intervention study to prevent Anemia in children under one year of age in the city of Nampula-Mozambique	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Comité Nacional de Bioética para Saúde	Universidade de São Paulo - Faculdade de Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-4r37q7z	<NULL>	Children between 6 and 8 months old; both sexes; residents in the territory of the selected Health Centers;  who are not taking iron supplements at the time of recruitment	Children with malaria, HIV, tuberculosis, hemoglobinopathies; premature babies (below 37 weeks); have any serious congenital disease;  have a severe physical or mental disability that impairs normal growth and development; those who are being treated for anemia at the initial time of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-6wczmgn	Use of a flowable resin in the management of palatal wounds after gingival graft removal: a clinical trial	Recruitment completed	Intervention	2024-11-11	<NULL>	<NULL>	7503	Use of flow resin in the management of palatal wound after removal of free gingival graft for pain modulation and post-operative healing: double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal da ParaÍba	Universidade Federal da ParaÍba	https://ensaiosclinicos.gov.br/rg/RBR-6wczmgn	<NULL>	Participants aged 18 years or older; both genders; indicated for mucogingival surgery associated with gingival grafting; systemically healthy; with plaque index and gingival index ≤20%; and with a palate free of pathology or morphological alterations	Patients with systemic health issues that contraindicate surgery (e.g., diabetes, decompensated cardiovascular disease, chronic kidney disease) or coagulation disorders (e.g., hemophilia A/B, von Willebrand disease, anticoagulant therapy). Those who are taking medication that may potentially interfere with the healing process (e.g., continuous use of steroidal anti-inflammatory drugs or chemotherapy). Smokers. Pregnant or breastfeeding women. Additionally, participants could not have undergone previous periodontal surgery in the study area; present opportunistic oral lesions in the palate region; or use dental prostheses that cover the palate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-32b24ck	The effect of supplementation of the nutrient Coenzyme Q10 in the treatment of Dermatological Wounds in people with Type 2 Diabetes Mellitus	Not yet recruiting	Intervention	2024-11-11	<NULL>	<NULL>	7504	Evaluation of Coenzyme Q10 supplementation on the development of Dermatological Wound healing in individuals with type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Federal de Juíz de Fora Campus GV	Universidade Vale do Rio Doce	https://ensaiosclinicos.gov.br/rg/RBR-32b24ck	<NULL>	People aged 18 years or older; of both sexes; people with confirmed diagnosis of type 2 diabetes mellitus and with dermatological lesions	People with generalized edema, pregnant women, breastfeeding women, who cannot perform anthropometric assessment, with amputated limbs or with some type of mental or physical disability; individuals with intrinsic vulnerability who have difficulty understanding their decisions due to a mental disorder, chemical dependency or neurological disease; people who consume antioxidant or omega 3 supplements and anticoagulants; smoking people	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-3fmt4pt	How an exercise program helps people with post-COVID after-effects	Recruitment completed	Intervention	2024-11-08	<NULL>	<NULL>	7493	Rehabilitation program for the functional recovery of patients with post-Covid-19 sequelae	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3fmt4pt	<NULL>	Adults aged 18 and over; of both sexes; previously diagnosed with Covid-19; referred for rehabilitation at least 21 days after the diagnosis of the acute illness; no signs and symptoms of active infection; at least 14 days after hospital discharge for those hospitalized; with persistent symptoms and/or post-covid dysfunction	Systolic blood pressure greater than or equal to 180 mmHg; acute chest pain; musculoskeletal impairment that limits walking; dizziness; palpitations; signs of current infection such as fever and flu-like symptoms; cognitive alteration that limits understanding of verbal commands and questions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-38mm3wn	Study on the efficiency of removing blood from the drain after heart surgery to avoid blockages	Data analysis completed	Intervention	2024-11-08	<NULL>	<NULL>	7494	Scientific evidence of the efficacy of mediastinal drainage milking in postoperative cardiac surgery as prevention of hematic occlusion: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-22	Faculdade de Medicina da Universidade Federal do Amazonas	Faculdade de Medicina da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-38mm3wn	<NULL>	Patients over 18 years old; being in the immediate postoperative period of any cardiac surgery by Median Sternotomy with mediastinal drain inserted; both sexes	Patients with mediastinal drainage inserted after surgical re-approach for any cause	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-3xqd5yz	Effect of Vagus Nerve Stimulation in women with Fibromyalgia	Recruiting	Intervention	2024-11-08	<NULL>	<NULL>	7495	Effect of Transcutaneous Auricular Vagus Nerve Stimulation in women with Fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-3xqd5yz	<NULL>	Female individuals; age between 18 and 65 years old; patients with fibromyalgia; walk independently; understand brazilian portuguese	IIndividuals with red flags like fracture or cancer; suspected or confirmed pregnancy; unstable heart conditions; absence of ear	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-4c3pdbz	Effects of periodontal therapy in individuals with obesity	Recruiting	Intervention	2024-11-08	<NULL>	<NULL>	7496	Effects of non-surgical periodontal therapy in the treatment of Periodontitis in individuals with obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4c3pdbz	<NULL>	Volunteers of both genders; presence of at least 15 natural teeth excluding third molars and teeth with indication for extraction; diagnosis of generalized periodontitis stage III grade A or B; 30% of teeth with probing depth and clinical attachment level greater than or equal to 5mm	Body Mass Index (BMI) between 25 kg/m2 and 29.9 kg/m2; presence of systemic conditions that may affect the progression of PE or the response to its treatment; long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and/or use of antimicrobials in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; chronic gastrointestinal diseases; extensive prosthetic rehabilitations; tobacco use currently or in the last 5 years; pregnancy and lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-2sgpdww	Natural product made from Green Banana for treating pimples	Recruitment completed	Intervention	2024-11-07	<NULL>	<NULL>	7491	Phytocosmetic based on green banana peel for acne treatment	<NULL>	1, non-randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade do Vale do Sapucaí	Universidade do Vale do Sapucaí	https://ensaiosclinicos.gov.br/rg/RBR-2sgpdww	<NULL>	Young people of both sexes; age between 18 and 25 years old; volunteer and sign the Free and Informed Consent Form (TCLE); acne lesions on the face with a significant impact on quality of life; Cardiff Acne Disability Index (CADI) scale with a score from 1 to 15	In other acne treatments; women using contraceptives; pregnant and breastfeeding women; allergies to one of the product’s components	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-86csj9y	Extreme rise in body temperature in Brazil	Recruiting	Observational	2024-11-07	<NULL>	<NULL>	7492	Malignant hyperthermia in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2010-01-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	Setor de Hipertermia Maligna, EPM/UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-86csj9y	<NULL>	History of susceptibility to malignant hyperthermia in the patient or first-degree relative, such as anesthetic malignant hyperthermia, intraoperative masseter hypertonia, neuroleptic malignant syndrome, exertional hyperthermia, exertion intolerance, idiopathic rhabdomyolysis, idiopathic elevation creatine phosphokinase, spontaneous masseter hypertonia and definitive myopathies or possibly associated with susceptibility to anesthetic malignant hyperthermia. Minimum interval of six months between the crisis suggestive of malignant hyperthermia and the muscle biopsy. Evaluation: all ages for clinical evaluation and 14 years for muscle biospsy; both sexes. Filling out the post-information consent form. Removal of a sufficient amount of muscle to carry out the muscle contracture test and the complete anatomopathological study. Positive muscle contracture test	Absence of history of susceptibility to malignant hyperthermia in the patient or first-degree relative	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-3hhm4r2	Impact after Physical Training on Heart Failure	Recruiting	Intervention	2024-11-06	<NULL>	<NULL>	7483	Effect of high-intensity interval Physical Training on cardiovascular and respiratory function and functional performance of patients with Heart Failure	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-09-09	Universidade de Pernambuco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-3hhm4r2	<NULL>	Outpatient follow-up for at least 6 months. Functional class (NYHA) I, II or III. Stable, with no history of hospitalization or emergency care in the last 2 months. Taking medications prescribed in the outpatient clinic and without changes in the last two weeks. Left Ventricular Ejection Fraction - LVEF less than 40% (medical history or complementary exam in the last year). Age between 18 and 65 years. Both sexes. Body Mass Index (BMI) between 18.5 and 34.5 kg/m2	Echocardiographic findings in the initial evaluation that differ from the eligibility criteria. Hypertrophic cardiomyopathy with outflow tract obstruction. Acute inflammatory or infectious heart disease in the last year. Limiting lung disease (forced expiratory volume in 1 second less than 50%). Evidence of neoplasia or treatment with chemotherapy or radiotherapy in the last 6 months. Significant pulmonary arterial hypertension reported in echocardiogram or medical history. Chronic renal failure on dialysis. Cognitive limitation or clinical condition limiting exercise. Poor adaptation to the cycle ergometer. Pregnant women. Patient on a heart transplant list. Patient with atrial flutter or atrial fibrillation (persistent or permanent). Pacemaker wearer. Regular practice of moderate or high intensity exercise or participation in a cardiovascular rehabilitation program in the last 4 weeks. Uncontrolled systemic blood pressure (SBP &gt; 180 mmHg and/or DBP &gt; 110 mmHg). Surgical planning in the next 3 months. Myocardial revascularization or myocardial infarction in the last year. Smoker. Cardiopulmonary Exercise Test - CPET with one of the following findings: Significant ventricular arrhythmia induced by exertion (non-sustained ventricular tachycardia, frequent ventricular ectopias), 2nd or 3rd degree atrioventricular blocks, significant electrocardiographic alterations in the ST segment indicative of myocardial ischemia in high intensity of exertion, dyspnea disproportionate to exertion, precordial pain, presence of new crackles or wheezes in respiratory auscultation during examination, sustained reduction of blood pressure in exertion, failure to identify the second ventilatory threshold. Abusive use of alcohol. Significant valvulopathy (mitral or aortic stenosis or insufficiency)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-2f836zh	Comparison of different weekly volume progressions in Resistance Training on muscle growth and proteolysis markers in trained Individuals	Recruitment completed	Intervention	2024-11-06	<NULL>	<NULL>	7484	Effects of different weekly volume progressions of Resistance Training morphological adaptations of trained young adults: a controlled, randomized, within-subject study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal de São Carlos	Laboratório de Adaptações Neuromusculares ao Treinamento de Força	https://ensaiosclinicos.gov.br/rg/RBR-2f836zh	<NULL>	Women and men; aged between 18 and 35; who have been practicing strength training for the lower limbs for at least 2 years and no more than 5 years; who perform a weekly volume of 12 to 20 sets for the quadriceps muscles (including the 45º leg press and extension chair exercises).	Use of anabolic steroids; chronic use of vitamin supplements and/or anti-inflammatory medications; any musculoskeletal injury of the lower limbs and neuromuscular disorders that could prevent the execution of the protocols proposed by the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-6p76t5x	Efficacy of a profissional use paste with PRG technology in reducing Dental Plaque in children with Molar-Incisor Hypomineralization (MIH)	Not yet recruiting	Intervention	2024-11-06	<NULL>	<NULL>	7485	Efficacy of a prophylactic paste with PRG technology in reducing Dental Plaque index in children with Molar-Incisor Hypomineralization (MIH): an in situ and in vivo study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6p76t5x	<NULL>	Minimum age of 7 and maximum age of 17 years; both sexes; diagnosis of Molar-Incisor Hypomineralization (MIH); signature of the Informed Consent Form (ICF) by the legal guardian and the Informed Assent Form (IAF) by the participant; high biofilm accumulation and poor oral hygiene	Presence of syndromes or general health conditions that prevent a complete clinical examination; children who do not allow the procedure; use of fixed appliances or metal bands that may interfere with the clinical examination of all tooth surfaces; children who are illiterate or semi-literate; patients requiring emergency treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-10p45rdg	Evaluation of the benefit of a new psychotherapy applied to students at the Federal University of Rio Grande do Norte in controlling Anxiety and Depression Symptoms through specific questionnaires for anxiety and depression and laboratory tests	Not yet recruiting	Intervention	2024-11-06	<NULL>	<NULL>	7486	Assessment of the efficacy of a novel brief psychotherapy technique applied to students at the Federal University of Rio Grande do Norte in controlling Anxious and Depressive Symptoms through specific questionnaires and biomarkers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Empresa Brasileira de Servicios Hospitalares - EBSERH	Empresa Brasileira de Servicios Hospitalares - EBSERH	https://ensaiosclinicos.gov.br/rg/RBR-10p45rdg	<NULL>	Students from the Federal University of Rio Grande do Norte attending the outpatient clinic in the Mental Health Unit  within the Clinical Medicine Department, Psychiatry Division, at the Onofre Lopes University Hospital; If on antipsychotics, the use must be stable, with no changes in psychotropic medications in the past 6 weeks; both sexes will be included without age limit	Drug use or substance dependence; smokers;  alcohol consumption; recent physical exercise within the past 48 hours; sleep of less than 7 hours the night before sample collection; imminent risk of suicide; schizophrenia; psychotic symptoms; bipolar disorder;  for women use of oral contraceptives or pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-6n5p6gw	Impact of N-acetylcysteine (NAC) supplementation in pregnancies with pre eclampsia	Recruitment completed	Intervention	2024-11-06	<NULL>	<NULL>	7487	N-acetylcysteine ​​supplementation in pregnant women with pre-eclampsia	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-06-21	Universidade Federal de Alagoas	Hospital Universitário Professor Alberto Antunes	https://ensaiosclinicos.gov.br/rg/RBR-6n5p6gw	<NULL>	Women; adolescents and adults; between 24 and 28 weeks of gestation; diagnosed with pre-eclampsia; attended prenatal care at the Professor Alberto Antunes University Hospital	Multiple pregnancies; women with neurological disorders and comorbidities that may influence the outcomes of pregnancy (diabetes mellitus, cardiovascular problems, urinary tract infection, kidney disease, autoimmune diseases, hepatitis, syphilis, human immunodeficiency virus, among others); as well as pregnant women who are alcoholics; smokers; those who use antioxidant and/or anti-inflammatory drugs; pregnant women whose newborns have serious malformations (cardiac, renal or hepatic) or genetic syndromes diagnosed during prenatal care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-5gqgs99	Effects of a Walking Program associated with Blood Flow Restriction on strength, muscle thickness, and gait in individuals with leg strength imbalance	Not yet recruiting	Intervention	2024-11-06	<NULL>	<NULL>	7488	Effects of a Walking Program associated with Partial Blood Flow Restriction on muscular and functional aspects in individuals with muscle strength asymmetry in lower limbs	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-20	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5gqgs99	<NULL>	Individuals aged between 18 and 59 years; muscle strength difference between lower limbs greater than or equal to 10 per cent in the knee extensor musculature (quadriceps), indicating asymmetry; medical clearance for training, granted by the physician associated with the study (Dr. Francisco Wekerlin Morozowski); signing the Informed Consent Form; completing 75 per cent of the proposed training sessions if selected for the intervention	Having conditions that prevent the completion of questionnaires, understanding of instructions, and performance of tests (e.g., severe vestibular deficits, mobility deficits, and cognitive impairment); having systolic blood pressure greater than or equal to 140 mmHg or diastolic blood pressure greater than or equal to 90 mmHg; having more than one risk factor for thromboembolism, which includes: body mass index greater than or equal to 30 kg/m². diagnosis of chronic inflammatory disease. history of pelvic, hip, and femur fractures. major surgeries in the last 6 months. diagnosis of varicose veins in the last 6 months. family history of deep vein thrombosis and pulmonary embolism. use of oral contraceptives. tobacco use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-38xfyp5	Comparison Between Two Exercise Protocols in the Treatment of Rotator Cuff Tendinopathy: randomized clinical trial	Recruitment completed	Intervention	2024-11-06	<NULL>	<NULL>	7489	Effects of Proprioceptive Neuromuscular Facilitation Exercises in the treatment of Rotator Cuff Tendinopathy: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-02	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-38xfyp5	<NULL>	Participants of both genders; aged between 18 and 65 years; who have had shoulder pain for at least three months, the pain should be localized in the lateral and proximal region of the superior aspect of the shoulder (corresponding dermatome of the C5 nerve root), and this complaint should be aggravated during the execution of at least 3 out of 5 specific tests for rotator cuff tendinopathy, which are: Neer, Hawkins-Kennedy, Painful Arc, Jobe, and lateral rotation against resistance; participants should not have passive limitations in flexion, abduction, and external rotation movements	Patients with any history of previous shoulder joint injury; radicular symptoms from the cervical spine; generalized pain condition; evidence of complete rotator cuff tear with loss of active shoulder mobility; fractures in adjacent joints (elbow, wrist/hand); participants with a clinical diagnosis of diseases such as rheumatoid arthritis, cancer, neurological diseases, cognitive disorders, and psychiatric illnesses; all with a history of alcoholism; smoking; those who are constantly using corticosteroids (injectable/oral) or anticonvulsants; and all who are unable to complete all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-2kcxnrt	New methodology to compare color changes during dental bleaching	Recruitment completed	Intervention	2024-11-06	<NULL>	<NULL>	7490	New methodology to compare color changes during dental bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Faculdade de Odontologia da Universidade de São Paulo	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2kcxnrt	<NULL>	Participants must be between 18 and 30 years old. Both sexes. Have good general and oral health. Both canines must be A2 or more saturated, which will be evaluated using Easy Shade	General exclusion criteria: pregnant or lactating women. Use of medications that may cause photosensitization of the skin. As local exclusion criteria: presence of severe tooth discoloration (e.g. tetracycline, fluorosis, etc.). Exacerbated dentin sensitivity. Presence of carious lesions or previous restorations, crowns, veneers and endodontic treatment on upper and lower anterior teeth. Dental bleaching carried out less than 3 years ago	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-368fdb3	Treatment of female pattern baldness using microneedling techniques: a scalp analysis	Data analysis completed	Intervention	2024-11-04	<NULL>	<NULL>	7478	Treatment of female pattern alopecia using microneedling techniques: clinical, dermatoscopic and  histopathological analysis of the scalp	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-30	Hospital das Clínicas da Universidade Federal do Paraná	Hospital das Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-368fdb3	<NULL>	Age greater than 18 years old and less than 65 years old; clinical and dermoscopic diagnosis of female pattern alopecia under regular treatment for at least 12 months with the same dosage of medications, and limited response to treatment	Clinical, dermoscopic or histological signs of scarring alopecia; non-compliance with any study procedures; triggers for telogen effluvium in the last three months before inclusion in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-3yrrhns	Virtual Reality Therapy for patients admitted to Intensive Care Units	Data analysis completed	Intervention	2024-11-04	<NULL>	<NULL>	7479	Comparison between three physiotherapeutic protocols in patients admitted to the Intensive Care Unit: Conventional Physiotherapy, Non-Immersive Virtual Reality Therapy and Combined Therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-08-14	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-3yrrhns	<NULL>	Patients who had been hospitalized since the day before the start of the protocol; with hemodynamic stability; age between 18 and 60 years; both sexes; with preserved sensitivity and cognitive abilities	Patients belonging to the group of vulnerable people, such as: pregnant women, institutionalized or indigenous people; patients who received systemic corticosteroids or neuromuscular blockers for more than 5 days were not included due to neuromuscular weakness caused by the medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-4ztjd48	Is exercising in water better than walking in water for relieving chronic pain in people with osteoarthritis?	Recruiting	Intervention	2024-11-04	<NULL>	<NULL>	7480	Are isolated exercises in water more effective than walking in water to reduce chronic pain in patients with Osteoarthritis?	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-23	Faculdade de Ceilândia da Universidade de Brasília	Hospital de Apoio de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4ztjd48	<NULL>	Clinical diagnosis of osteoarthritis in the knee; pain for more than 12 weeks; minimum score of 24 points on the Mini Mental State Examination for literate participants, and 20 points for illiterate participants; Individuals aged 48 to 80 years old; individuals who can walk outside of water with or without assistance	Present any condition that prevents you from carrying out the training; be attending another specialized rehabilitation program; having urinary or fecal incontinence;  present open wounds, skin rashes and hemorrhagic areas; having acute respiratory distress or insufficiency; being a carrier of infections in general; have performed infiltration in the last 3 months; present uncontrolled blood pressure changes and cardiac decompensation; Having knee pain due to another pathology;  have already had knee surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-35qcc8f	The Effects of Pilates on Menopausal Women on Urine Loss, Heart Health and Sleep Quality	Not yet recruiting	Intervention	2024-11-04	<NULL>	<NULL>	7481	The effects of Mat Pilates in postmenopausal women with Stress Urinary Incontinence, Cardiovascular Risks and Sleep Quality: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2026-05-04	Faculdade de Educação Física e Fisioterapia - Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia - Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-35qcc8f	<NULL>	Women after menopause; aged between 45 and 65 years; have stress urinary incontinence; if you have high blood pressure, it must be controlled; have a Body Mass Index (BMI) between 25 and 35; be sedentary or perform less than 150 minutes of physical activity per week; pelvic floor muscle strength greater than or equal to 2 on the modified Oxford pelvic floor scale	Not knowing how to read and not being able to answer the questionnaires; having a urinary tract infection at the time of treatment; feeling pain during sexual intercourse during penetration and/or constipation; using hormone therapy; being a smoker; having undergone any previous pelvic surgery (including surgery for stress urinary incontinence, with the exception of cesarean section); not having undergone previous pelvic radiotherapy; having a neurological disease; having only Urgency Urinary Incontinence or Overactive Bladder Syndrome; using beta-blockers; not accepting to participate in the research and/or not signing the TCLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:15
RBR-4c37bch	Effect of Melatonin on anxiety before dentist appointment in children	Recruiting	Intervention	2024-11-04	<NULL>	<NULL>	7482	Effect of Melatonin on pre-consultation anxiety in pediatric dental care: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-29	Centro Universitário CESMAC	Centro Universitário CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-4c37bch	<NULL>	Children aged between 3 and 10 years; of both sexes; with physical status according to American Society of Anesthesiology (ASA) I and II; scheduled for dental care at Clinical School of Dentistry of the Centro Universitário Cesmac, PAM Salgadinho and Nutritional Recovery and Education Center	Children with mental disorders and disabilities that difficult them to understand commands; children have previously used anxiolytic and/or antipsychotic medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-4yydrsg	Effects of Aerobic Training performed on stationary bicycle on cognitive function and cerebrovascular blood vessel function in patients with Parkinson&apos;s Disease	Recruiting	Intervention	2024-11-04	<NULL>	<NULL>	7749	Effects of Aerobic Training on cerebrovascular and cognitive functions and gait of patients with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-19	Universidade Nove de Julho	Associação Brasil Parkinson	https://ensaiosclinicos.gov.br/rg/RBR-4yydrsg	<NULL>	Individuals of both sexes having a previous diagnosis of Parkinson&apos;s disease; be undergoing pharmacological treatment for PD; be at least 40 years old	Being in Hoehn &amp; Yahr stages 4 and 5 of Parkinson&apos;s disease; have other neurological diseases in addition to Parkinson&apos;s disease; present a previous diagnosis of cardiovascular disease (except systemic arterial hypertension) or presence of symptoms suggestive of an unknown cardiovascular disease; inability to move independently without the aid of aids; present contraindications for aerobic training; be performing aerobic training regularly; have long COVID; severe cognitive impairment defined by a score lower than 18 on the Mini Mental State Examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-4m2qhhv	Immediate effect of Weight Training, Vascular Occlusion and Jumping on performance in the 50-meter freestyle	Data analysis completed	Intervention	2024-11-01	<NULL>	<NULL>	7475	Immediate effect of Strength Training, Blood Flow Restriction and Plyometrics on swimming&apos;s 50-meter sprint performance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Departamento de Educação Física - Universidade Federal do Rio Grande do Norte	Departamento de Educação Física - Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4m2qhhv	<NULL>	Participants aged between 14 and 40 years old; both genders; who had no musculoskeletal injuries; who provided a signed Free and Informed Consent Form (FICF); who practiced swimming at least three times a week	Participants who reported using any substance that could increase sports performance during the tests; who are at risk of pulmonary thromboembolism; venous thrombosis; varicose veins; heart failure; who have not been training regularly; who did not participate in any phase of the study or dropped out for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-6dq3qgn	Use of Electrical Stimulation for physical recovery of the elderly. Study in a care unit	Recruiting	Intervention	2024-11-01	<NULL>	<NULL>	7476	Whole-Body Electromyostimulation in the rehabilitation of elderly people in care transition unit: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Hospital Universitário Walter Cantídio da Universidade Federal do Ceará	Instituto de Saúde e Gestão Hospitalar	https://ensaiosclinicos.gov.br/rg/RBR-6dq3qgn	<NULL>	Over 50 years old; without physical limitations for the intervention; both sexes	Diagnosis of severe cardiac, renal and/or hepatic pathologies; uncontrolled Epilepsy; use of pacemaker; severe neuromuscular disease; Cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-9ndj8xs	Educational strategy for the revention of Urinary Tract Infections in women in the prison system	Recruitment completed	Intervention	2024-11-01	<NULL>	<NULL>	7477	Health promotion and quality of life in the penitentiary system of Ceará	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-09	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9ndj8xs	<NULL>	Women; aged 18 years and above; incarcerated within the prison system regardless of the prison regime or time remaining to serve their sentence	Women with physical conditions that prevent participation in the study or responding to data collection instruments; women who refuse to respond to the general evaluation questionnaires and the initial Knowledge, Attitudes, and Practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-8hkzzxn	The effects of home exercise guidance on improving strength and mobility in older adults cancer patients	Not yet recruiting	Intervention	2024-10-31	<NULL>	<NULL>	7467	The effects of home exercise guidance on improving strength and functional mobility in older adults cancer patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Hospital de Clínicas da Faculdade de Medicina de Ribeirão Preto	Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-8hkzzxn	<NULL>	Individuals of both sexes. over 60 years old. diagnosed with cancer. Who are under follow-up at the Hospital das Clínicas de Ribeirão Preto in the Geriatric Oncology Outpatient Clinic. capable of using a cell phone for telephonic follow-up or having a companion and/or caregiver to assist the older adult in accessing treatment	A low score on cognitive screening using the 10-point Cognitive Screener (10-CS); according to the level of education; neurological disease; bone metastasis; palliative care; decompensated cardiovascular disease; or blood pressure equal to or greater than 160/90mmHg	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-9p22fp3	Clinical and microbiological analysis of Teeth with Aesthetic Restorations made at or below the gingival level	Recruitment completed	Observational	2024-10-31	<NULL>	<NULL>	7468	Clinical and microbiological analysis of Teeth Restored with Porcelain Veneers with supragingival and intrasulcular preparations: a cross-sectional study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-02	Centro de Pesquisa Odontológicas São Leopoldo Mandic SS	Centro de Pesquisa Odontológicas São Leopoldo Mandic SS	https://ensaiosclinicos.gov.br/rg/RBR-9p22fp3	<NULL>	Be between 18 and 40 years old; both gender; present restorative treatment with ceramic laminates in maxillary anterior teeth with at least 1 cemented ceramic laminate with margin in the supragingival region (GSup) or at least one cemented ceramic laminate with margin in the intrasulcular region up to 0.5 mm (GInt); have been rehabilitated for at least 1 year; have at least 20 teeth in the mouth; Absence of periodontitis (periodontal pocket larger than 4 mm accompanied by proximal bone loss)	Smoking patients; systemic disorders; diabetics; patients who use anti-inflammatory medication chronically 3 months before the study; use of antibiotics 3 months before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-5v9wmqg	Clinical study comparing Non-surgical Periodontal Therapy with and without association with Antimicrobial Photodynamic Therapy (aPDT- laser light) for Periodontitis	Recruitment completed	Intervention	2024-10-31	<NULL>	<NULL>	7469	Randomized clinical trial comparing Non-surgical  Periodontal Therapy with and without association with Antimicrobial Photodynamic Therapy (aPDT) in the treatment of Periodontitis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-09	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5v9wmqg	<NULL>	Individuals with periodontitis; over 35 years of age; of both genders and with 10 or more teeth present in the mouth	Patients with type 1 and type 2 diabetes; chronic kidney disease; malignant neoplasms; Acquired Immune Deficiency Syndrome, autoimmune diseases; be pregnant or breastfeeding; being immunosuppressed by medication; have evidence of other ASA III and IV systemic diseases; have changes in menstrual flow; be smokers or ex-smokers for less than twenty years; being users of orthodontic appliances; have a history of using steroidal or non-steroidal anti-inflammatory drugs in the previous three months and during the study; use of antibiotics in the last 4 months; use of any dietary supplements including antioxidant supplements in the last six months before the study; following any specific diet in addition to their usual diets during the last six months and having received supra and subgingival scaling and or periodontal surgery in the six months before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-9gzqp3v	Effect of Probiotic Mixture Supplementation on Constipation	Data analysis completed	Intervention	2024-10-31	<NULL>	<NULL>	7470	Effect of Probiotic Mix Therapy on Intestinal Constipation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-19	Faculdade de Nutrição - Universidade Federal de Goiás	Faculdade de Nutrição - Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9gzqp3v	<NULL>	Women; age between 20 and 59; self-reported stool types two to four on the Bristol Stool Scale; who had at least two of the criteria on the Rome IV Index	Women undergoing bariatric surgery; history of persistent diarrhea or inflammatory bowel disease; irritable bowel syndrome; vegetarian or on a diet; regular alcohol consumption (&gt; 7 drinks/week); smokers; moderate or vigorous exercise &gt; 3 h/week; use of antibiotics, laxatives, immunosuppressants, diuretics and antacids within one month before the start of the intervention; use of probiotic, prebiotic or symbiotic supplements; use of fermented foods during this same period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-2v3sqdx	A test with patients aimed at proving the efficacy of Hycos Dérmico, assisting in the application of wound dressings without damaging the skin affected by the disease.	Recruiting	Intervention	2024-10-31	<NULL>	<NULL>	7471	Single-blind clinical study on the efficacy and safety of the product Hycos Dérmico	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-10	Instituto de Saúde e Bem estar da Mulher	Nipo Serviços Médicos SS Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2v3sqdx	<NULL>	The participating patient has a wound, lesion, or bedsore. The injury requires dressings. Age between 18 and 90 years old. Any ethnicity, color/race, and skin phototype. Both genders. Patients are in the early stages of treatment	Pregnancy. Neonates. Sensitivity to the components of the medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-557mbvy	Intervention with access information via cell phone to increase the use of the HPV vaccine in people living with HIV/AIDS	Data analysis completed	Intervention	2024-10-31	<NULL>	<NULL>	7472	Mobile device intervention to increase HPV vaccine coverage in people living with HIV/AIDS	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-06	Centro de Pesquisas Gonçalo Moniz - FIOCRUZ/ BA	Centro de Pesquisas Gonçalo Moniz - FIOCRUZ/ BA	https://ensaiosclinicos.gov.br/rg/RBR-557mbvy	<NULL>	Women and men between the ages of 18–45 years; living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS); and who provided informed consent to participate	Women and men who had received any dose of human papillomavirus (HPV) vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-55s62wd	Cell count with changes in the nucleus in individuals with Periodontitis undergoing Non-Surgical Periodontal Treatment associated or not with Antimicrobiana Photodynamic Therapy (Laser Light)	Recruitment completed	Intervention	2024-10-31	<NULL>	<NULL>	7473	Quantification of micronuclei in individuals with Periodontitis undergoing Non-Surgical Periodontal Treatment associated or not with Antimicrobial Photodynamic Therapy: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-09	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-55s62wd	<NULL>	Patient with periodontitis; over 35 years old; both genders; with 10 teeth or more in the mouth	Patients with severe motor difficulties; people with type 1 and type 2 diabetes; of chronic kidney disease; from malignant neoplasms; Acquired Immunodeficiency Syndrome; of autoimmune diseases; pregnant or breastfeeding women; immunosuppressed by medication; have evidence of other ASA III and IV systemic diseases; smokers or ex-smokers for less than ten years; users of orthodontic appliances; have a history of using steroidal or non-steroidal anti-inflammatory drugs in the previous three months and during the study; use of antibiotics in the last 4 months or any dietary supplements, including antioxidant supplements, in the last six months before the study; followed any specific diet in addition to their usual diet during the last six months and had received supra- and subgingival scaling and/or periodontal surgery in the six months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-10qchkrp	Effect of music as complementary therapy in bed bath in patients after orthopedic surgery: Randomized Clinical Trial	Recruiting	Intervention	2024-10-31	<NULL>	<NULL>	7474	Effect of music as Complementary Therapy in bed bath in patients in the Postoperative period of Orthopedic Surgeries: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Centro Universitário FMABC	Centro Universitário FMABC	https://ensaiosclinicos.gov.br/rg/RBR-10qchkrp	<NULL>	Patients on the first and second postoperative day who underwent orthopedic surgeries; Patients of both sexes over the age of 18 years in the postoperative period of orthopedic surgeries receiving analgesia; Patients who will undergo bed bath without scalp hygiene	Patients with hearing impairment; Patients who are capable of being sent to the spray bath or who will undergo the bed bath procedure with scalp hygiene; Patients with a Glasgow Coma Scale result greater than 14; Patients who do not like music or associate music with negative experiences	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-825qxqw	Comparison of the durability of steel crowns and orthodontic bands in children with deficiencies in dental caries treatment - a randomized controlled clinical study	Recruitment completed	Intervention	2024-10-30	<NULL>	<NULL>	7465	Comparison of the effectiveness of Hall technique in relation to cementation of Orthodontic bands in the treatment of caries lesions in deciduous teeth of children with disabilities - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Instituto e Centro de Pesquisas São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-825qxqw	<NULL>	Children with cognitive impairment; both sexes; diagnosis of mild to moderate learning deficit; age range from 4 to 10 years; with the presence of extensive caries lesions involving more than one surface of the tooth, presenting an International Caries Detection and Assessment System score of 5 or 6; with the possibility of sending for 12 months; in which the guardians agreed and agreed to the Free and Informed Consent Form; if the patient had more than one tooth with caries lesion involving two or more surfaces, this patient contributed more than one tooth to a sample	Children whose teeth had pulp exposure; who presented spontaneous pain; teeth in the process of advanced rhizolysis presenting mobility; presence of swelling or fistula near the tooth; furcation or cervical lesion; teeth with restorations, sealants or defects in enamel formation were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-6mctrm2	Incidence of Thrombosis After Limb Salvage Surgery in Patients Receiving Rivaroxaban or Standard Treatment	Recruiting	Intervention	2024-10-30	<NULL>	<NULL>	7466	Incidence of Venous Thromboembolism post-revascularization of the lower limb in patients receiving Rivaroxaban in arterial dose versus standard treatment - randomized clinical trial	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2024-03-12	Hospital das Clínicas da Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6mctrm2	<NULL>	Adult participants, with no age limit; regardless of gender; patients with threatening ischemia of the limb and with a proposal for limb revascularization, either by angioplasty or by bypass surgery, at the Vascular Surgery Service of the Hospital das Clínicas of the Federal University of Pernambuco, a branch of the Brazilian Hospital Services Company (HC/EBSERH – UFPE) and sign the free and informed consent form (TCLE)	Patients who present a symptomatic venous thromboembolism (VTE) event during hospitalization will be excluded, they will need full anticoagulation and no longer prophylactic; patients who have any contraindications to the use of Rivaroxaban; do not return for the 30th post-operative day consultation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:22
RBR-7qzb27m	Antibacterial activity of a Simvastatin emulsion in patients with Atopic Dermatitis	Recruiting	Intervention	2024-10-29	<NULL>	<NULL>	7461	Antimicrobial Activity of a Topical Simvastatin Emulsion in patients with Atopic Dermatitis: double-blind randomized, placebo controlled, crossover clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2022-07-15	Faculdade de Ciências Farmacêuticas da Universidade Estadual de Campinas	Faculdade de Ciências Farmacêuticas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7qzb27m	<NULL>	Age between 2 and 60 years; Atopic Dermatitis  diagnosis according to the Hanifin and Rajka criteria, confirmed by reviewing the medical record; patients under follow-up at the dermatology outpatient of the referred hospital for at least 6 months; presence of active lesions in the upper limbs; not using topical corticosteroids of any potency at the product application site 30 days before the start of the study; atopic dermatitis severity assessed by a physician through the measurement of the Eczema Activity Severity Index (EASI) greater than 7; atopic dermatitis severity assessed by a physician using the Atopic Dermatitis Antecubital Severity score (ADAS); both genders	Presence of any other dermatosis in the product application area; history of hypersensitivity to simvastatin oral administration or any other statin; unstable skin condition defined by at least one of the following criteria in the last 3 months: change of systemic medication, antibiotics uses, hospitalization due to atopic dermatitis; oral antihistamines will be allowed as long as they are maintained at the dose prior to the start of the study; change in topical treatment in the month prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-5n3kj5t	Results comparison between patients with pectoralis muscle rupture operated with thigh fascia graft or knee flexor tendon	Recruiting	Intervention	2024-10-29	<NULL>	<NULL>	7462	Surgical treatment of patients with chronic rupture of the pectoral major muscle tendon with fascia lata graft or semitendineous graft: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de São Paulo - Escola Paulista de Medicina	Universidade Federal de São Paulo - Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-5n3kj5t	<NULL>	Patients with chronic total rupture, with more than 3 weeks of injury; lesions visualized by magnetic resonance and without retraction greater than the nipple line in the axial plane on T2; lesions occurred during weight training or CrossFit; patients average aged between 20 and 40 years	Patients who do not return for follow-up; not undergo the proposed exams or evaluations; patients who end up being disconnected from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-7d4c99f	Comparison of the effects of Dexamethasone and Non-Steroidal Anti-inflammatories in the post-operative Removal of wisdom teeth	Terminated	Intervention	2024-10-29	<NULL>	<NULL>	7463	Comparison of the effects of Dexamethasone and Non-Steroidal Anti-inflammatories in the post-operative Removal of third molar extractions: randomized and triple blind clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Santo Amaro	Universidade Santo Amaro	https://ensaiosclinicos.gov.br/rg/RBR-7d4c99f	<NULL>	They presented good systemic health conditions (ASA I); were between 18 and 35 years of age of both sexes; were indicated for extraction of the 38 and/or 48 impacted or semi-impacted dental elements, requiring a total mucoperiosteal flap and osteotomy	Patients who did not meet these inclusion criteria; who had any local inflammatory or infectious condition that would contraindicate tooth extraction; any type of hypersensitivity reaction to the medicinal substances that were used in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-76xg97x	Evaluation and satisfaction of methods for labor induction	Not yet recruiting	Intervention	2024-10-29	<NULL>	<NULL>	7464	Interventions for improving success rates and satisfaction in labor induction: B.O.M. study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Hospital da Mulher Professor Doutor José Aristodemo Pinotti da Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-76xg97x	<NULL>	Women above 18 years old; nulliparous and multiparous women; gestational age of 37 weeks or more; single pregnancy; cephalic presentation; intact membranes; bishop score of 6 or less; and cervical dilation of 2 centimeters or less	Patients who have any contraindication to vaginal birth; category 3 fetal heart rate tracking; presence of hemolysis; elevated liver enzymes and low platelet syndrome (HELLP); eclampsia; growth restriction below the 10th percentile (Hadlock growth curves) with reversed flow in doppler studies of the umbilical artery; restriction below the 5th percentile with elevated, absent, or reversed flow on doppler studies of the umbilical artery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-10367s7j	Characterization of Infrared Thermography of the masticatory muscles in normal people and people with Temporomandibular Disorder	Recruiting	Observational	2024-10-28	<NULL>	<NULL>	7460	Thermographic Characterization of the mastigatory muscles in normal individuals and with Temporomandibular  Dysfunction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-26	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-10367s7j	<NULL>	individuals between 20 and 50 years old; without Temporomandibular disorders; patients with Temporomandibular disorders of both sexes	history of trauma to the face or Temporomandibular joints; systemic disease; arthritis;  osteoarthritis; neuromuscular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-4d3x68p	Training with brain-computer interface for hand in individuals post-Stroke	Recruiting	Intervention	2024-10-25	<NULL>	<NULL>	7459	BCI for upper limb rehabilitation in individuals after Stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-31	Instituto de Ensino e Pesquisa Alberto Santos Dumont	Instituto de Ensino e Pesquisa Alberto Santos Dumont	https://ensaiosclinicos.gov.br/rg/RBR-4d3x68p	<NULL>	Individuals with hemiparesis post-stroke; over 18 years old; of both sexes; in the chronic phase; capable of performing residual movement in the paretic limb with assistance or device; who do not present contractures or deformities in upper limbs; with a score of 2 on the Modified Ashworth Scale and with a score on the Mini-Mental State Examination	Participants presenting neglect syndrome; significant pain in the limb, excessive fatigue, non-preserved cognition, inability to perform or understand the necessary procedures; and those who do not follow the protocol during the established period will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-1094zfg5	Assessment of patient satisfaction with different types of periodontal probes	Not yet recruiting	Intervention	2024-10-24	<NULL>	<NULL>	7456	Assessment of patient satisfaction with periodontal probes: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-10	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-1094zfg5	<NULL>	Age between 18 and 60 years; absence of gingival inflammation or periodontal disease; consent to participate in the research; both genders	Self-reported systemic disease; smokers, pregnant women and those with dentin hypersensitivity; patient using non-steroidal anti-inflammatory drugs and analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-3vr6nq8	Use of SecurAcath and Cyanoacrylate Glue for prevention of Peripheral Insertion Central Catheters Dislodgement in Children: a clinical study	Not yet recruiting	Intervention	2024-10-24	<NULL>	<NULL>	7457	Securacath and Cyanoacrylate Glue in reducing Central Venous Catheters Displacement in children: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-10-30	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-3vr6nq8	<NULL>	Child or adolescent; both sexes; age range between 0 days and incomplete 15 years of age; indication for insertion of Peripherally Inserted Central Catheter equal to or greater than 2.8 French; child or adolescent scheduled for hospital follow-up	Children or adolescents or their guardians who request the withdrawal of their data from the research after the research data collection protocol has begun or at its end; children or adolescents allocated to the Experimental Group and for whom, by decision of the professional at the time of insertion of the peripherally inserted central catheter, it was not possible to use the SecurAcath® or Cyanoacrylate Glue devices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-4hbxk9k	Evaluation of laser in the prevention of Mucositis in patients with head and neck Cancer	Recruiting	Intervention	2024-10-23	<NULL>	<NULL>	7452	Evaluation of a Laser Photobiomodulation protocol on the prevention of Mucositis in patients with head and neck Cancer: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-15	Universidade Federal do Amazonas	Fundação Centro de Controle de Oncologia do Estado do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4hbxk9k	<NULL>	Patients aged 18 years or over; with a definitive diagnosis of head and/or neck cancer (lip, oral cavity and pharynx) determined by biopsy; who have started antineoplastic therapy no more than 24 hours before the first laser irradiation; whose antineoplastic treatment will consist of a total dose of RT 70 Gy, with a minimum dose of 50 Gy administered and chemotherapy with cisplatin weekly (30 to 40 mg/m2) and every 21 days (100 mg/m2)	Patients previously irradiated in the head and neck region; patients with metastasis; patients with any interruption of treatment; patients who are unable to attend appointments; patients undergoing unilateral irradiation of the head and neck; patients undergoing surgical resection of the facial nerve and/or its branches; patients with trismus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-5454tsk	Effect of Pilates and Walking on the pelvic muscles of postmenopausal women	Not yet recruiting	Intervention	2024-10-23	<NULL>	<NULL>	7453	Effects of Pilates and Aerobic Exercise on the pelvic floor musculature in postmenopausal women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5454tsk	<NULL>	Postmenopausal woman with 1 to 10 years of amenorrhea; having a cardiometabolic condition (hypertension, diabetes, high cholesterol, or being overweight); and having a medical clearance to engage in physical activities	Have physical problems or cardiovascular complications that prevent them from performing physical exercises; a history of stroke or acute myocardial infarction; renal pathologies; use medications that affect lipid metabolism; are smokers; have intolerance to vaginal palpation and/or the insertion of a pressure manometer; presence of neurological and/or cognitive impairments that hinder understanding of the proposed procedures; undergoing physical therapy for pelvic floor dysfunctions  before and during the participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-286pv6k	Clinical evaluation of color compatibility between monochromatic composite resin and the tooth after dental whitening	Not yet recruiting	Intervention	2024-10-23	<NULL>	<NULL>	7455	Evaluation of color compatibility of monochromatic composite resin with the tooth after in-office bleaching - randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-286pv6k	<NULL>	Age between 18 and 60 years; in good general and oral health; presenting healthy upper canines with color variation A3 to D4 on the Vita scale; no pain or pulp alteration in the tooth to be whitened; consent to participate in the research; both sexes	Use of fixed orthodontic appliances; active periodontal disease; endodontic treatment on the upper anterior teeth; pregnant patients; smokers; presence of cavities or restoration in the tooth to be whitened	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-2j2zw3h	Adaptive evaluation of treatments for arboviruses (Adapta-Arbo): A clinical study to compare the dose-response relationship between Molnupiravir and placebo in patients with Chikungunya and Dengue	Recruiting	Intervention	2024-10-22	<NULL>	<NULL>	7446	Adaptive evaluation of arbovirus treatments (Adapta-Arbo): A randomized, adaptive, double placebo-controlled trial to evaluate the pharmacodynamics of Molnupiravir in early symptomatic Chikungunya and Dengue infections	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-03-19	Universidade Federal de Minas Gerais	Instituto Nacional de Ciência e Tecnologia Em Dengue	https://ensaiosclinicos.gov.br/rg/RBR-2j2zw3h	<NULL>	A patient who understands the procedures, is willing and able to give informed consent for full participation in the study. The participant must be an adult between 18 and 65 years old at the time of consente and male or female. The participant has to present symptoms compatible with the diagnosis of an acute arboviral infection, including fever, myalgia, arthralgia or arthritis, headache, conjuntivitis, which began no later than 60 hours before the time of inclusion. The participant agrees and is able to adhere to all study procedures, including providing contact information and is available for follow up visits	Patients taking any chronic medication that may interact with Molnupiravir or have antiviral activity in the opinion of the study&apos;s principal investigator. Patients with any disease/chronic condition with significant comorbidity in the opinion of the study&apos;s principal investigator. Presenting clinically relevant laboratory abnormalities. Contraindication or hypersensitivity to molnupiravir. Current participation in another drug clinical trial. Evidence of another infectious condition that explains the current symptoms. And, for women, pregnancy, trying to become pregnant, or lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-27nnt5g	Effect of Aromatherapy on Nausea and Vomiting caused by Chemotherapy in patients with Breast cancer	Recruiting	Intervention	2024-10-22	<NULL>	<NULL>	7447	Effect of Aromatherapy on Nausea and Vomiting induced by Chemotherapy in patients with breast Cancer: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-04	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-27nnt5g	<NULL>	"Women. Be undergoing curative antineoplastic chemotherapy treatment, regardless of the histological type and staging of the tumor. Have undergone at least one cycle of chemotherapy. Have at least two cycles of chemotherapy to be performed. Be using a chemotherapy protocol that has emetic potential.
Be aged 18 or over. Be in a physical and cognitive condition to understand the Free and Informed Consent Form and to participate in the study by responding to the Morrow scale instrument and the sociodemographic and clinical questionnaire form"	Being delirious or mentally confused. Be on other types of cancer treatment, other than just antineoplastic chemotherapy. Have injuries or allergic processes on the face. Being pregnant. Have a history of chronic obstructive pulmonary disease, asthma or other respiratory disorder that may be exacerbated by strong odors, inability to smell fragrances, allergy or sensitivity to peppermint or any strong odor. Use another integrative therapy to treat chemotherapy-induced nausea and vomiting during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-5f7x539	Assessment of skin irritability after using a health product	Not yet recruiting	Intervention	2024-10-22	<NULL>	<NULL>	7448	ORC_115312_EN24-0384-01 - Assessment of Primary Dermal Irritability, Cumulative Dermal Irritability and Dermal Sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-03	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5f7x539	<NULL>	Participants of both sexes; aged 18 to 70 years; skin of the application region integrates; agreeing to follow the test procedures and to attend the clinic on the days and times determined for medical evaluations and for application and reading of dressings; understanding, consent and signing of the Free and Informed Consent Term (ICF)	Pregnancy or risk of pregnancy and/or lactation; use of anti-inflammatory drugs and/or immunosuppressive drugs for up to three months before selection; immunosuppression by drugs or active disease; decompensated endocrinopathies; Personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; expect intense exposure to sunlight or tanning sessions during the study period; provision of bathing in the sea, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks before selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization, irritation or photosensitization to topical products; active skin pathologies (local and/or disseminated) that may interfere with the study results; skin reactivity; use of new drugs/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient in study products (test or comparative product); history of non-adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-6scsrgp	Evaluation of treatment with orthodontic aligners during different periods of use	Recruitment completed	Intervention	2024-10-22	<NULL>	<NULL>	7449	Evaluation of the effectiveness of orthodontic treatment with clear aligners in different wear time protocols: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6scsrgp	<NULL>	Participants aged between 14 and 60; both sexes; complete permanent dentition; Angle Class I; good periodontal health; mild to moderate malloclusion	Patients with incisive agenesis; dental losses (except third molars); or indication of premolar extraction for orthodontic purposes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-487ggmz	Evaluation of two materials in maxillary sinus grafting	Data analysis completed	Intervention	2024-10-22	<NULL>	<NULL>	7450	Histomorphometric comparative analysis of two different bovine-derived biomaterials in human maxillary sinus augmentation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-20	Universidade do Grande Rio	Universidade do Grande Rio	https://ensaiosclinicos.gov.br/rg/RBR-487ggmz	<NULL>	Inclusion criteria consisted of volunteers with minimum of 18 years-old requiring reconstruction of the posterior maxillary bone height; with residual bone height in the maxillary sinus floor of less than 5 mm as determined by prior cone-beam computed tomography	Patients will be excluded if present with uncontrolled periodontal disease; uncontrolled systemic diseases; sinus pathologies; smoking habits; residual roots in the maxillary sinus; and those who had undergone head and neck radiation therapy for cancer treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-72hp4v9	Evaluation of the effects of overhead infrared light irradiation in patients with Parkinson&apos;s disease	Recruiting	Intervention	2024-10-22	<NULL>	<NULL>	7451	Evaluation of the effects of transcranial photobiomodulation in patients with Parkinson´s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Federal de Pernambuco	Associação de Parkinson de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-72hp4v9	<NULL>	As inclusion criteria, volunteers of both genders who are patients diagnosed with Parkinson disease (PD) in stages I to III of the Hoehn and Yahr scale (Shenkman et al., 2001); they must be between 18 and 60 years old; volunteers of both sexes will be accepted; volunteers in the active period must present themselves without severe dyskinesia; they must be able to remain in an upright position, standing still for at least 2 minutes and walk without assistance for 10 meters; free from sensory changes in the head region or inability to communicate with the researcher in any type of eventuality such as emergency situations	As for exclusion criteria, participants must not present any neurological condition other than Parkinson disease (PD), such as Alzheimer&apos;s disease and other dementias; sequelae of stroke; cognitive insufficiency; delirium; depression; use deep brain stimulators or any other types of brain implants; patients will also be excluded if they have a history of head surgery; cranioplasty; metallic implants; stents; ventriculoperitoneal shunts; hydrocephalus; microcephaly; traumatic brain injury; myelomeningocele; meningocele and any other malformation of the central nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-6zvxsdb	Effect of an intervention with Electrical Stimulation of the brain through the skull bones associated with Motor Exercises on motor symptoms in people with Parkinson&apos;s disease	Not yet recruiting	Intervention	2024-10-21	<NULL>	<NULL>	7444	Effect of an intervention with Electrical Stimulation on the brain through the skull bones combined with exercises on locomotion and balance in individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Faculdade de Ciências e Tecnologia - Universidade Estadual Paulista	Faculdade de Ciências e Tecnologia - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6zvxsdb	<NULL>	Individuals with Parkinson&apos;s Disease; of both sexes; they must have the disease diagnosed by doctors following the criteria determined by the London Brain Bank; age equal to or greater than 50 years; and present independent locomotion (without assistance from people or use of auxiliary devices)	Staging greater than 3 on the Hoehn &amp; Yahr scale; orthopedic and vision problems that make it impossible to comply with the experimental protocol; presence of another neurological disease, in addition to Parkinson&apos;s Disease (PD); indicative of cognitive decline (score less than 24 on the Mini Mental State Examination - MMSE); individuals at risk of receiving Transcranial Direct Current Stimulation - tDCS (e.g., neural implants, individuals with deep brain stimulation implants, pacemaker, history of seizures and epilepsy); have uncontrolled diseases (e.g. high blood pressure and diabetes); experience intense pain or discomfort that makes it impossible and difficult to perform motor exercises; and not understanding the motor exercises proposed in the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-2qxwg2g	Evaluation of vacuum dressing on high-risk incisions in reducing complications	Recruiting	Intervention	2024-10-21	<NULL>	<NULL>	7445	"Assessment of the impact of incisional negative pressure therapy on the reduction of
complications from risky incisions"	<NULL>	4, randomized-controlled, n/a	4	<NULL>	<NULL>	<NULL>	2024-09-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2qxwg2g	<NULL>	Both sexes; age from 18 to 80 years old; have a risky incision (according to study criteria); closure was performed by the study team; agree to the study conditions	Wound management in another health service; wound of tumoral etiology; device malfunction with loss of therapy; loss of follow-up; refusal to study procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-3p6t9pm	Ultrasonographic effect of Shoulder and Surgical Table Rotation maneuvers on the lumbar and thoracic vertebral spaces of Elderly	Data analysis completed	Intervention	2024-10-21	<NULL>	<NULL>	7729	Impact of Shoulder Rotation and Table Tilt Maneuvers on the lumbar and thoracic acoustic window of elderly individuals	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-19	Universidade Federal de Pernambuco	Hospital da Restauração	https://ensaiosclinicos.gov.br/rg/RBR-3p6t9pm	<NULL>	Both genders; 65 years or older; agree to participate and sign the free and informed consent form	Allergy to ultrasound gel; patients who are unable to perform adequate positioning to capture images; low quality image or with questionable measurement of the posterior longitudinal ligament; who have a history of trauma, surgery or abnormality (congenital or acquired) of the spine or shoulders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-3ms5dgd	Effect of the Supported Self-Care technique on adequate follow-up of Warfarin treatment	Data analysis completed	Intervention	2024-10-19	<NULL>	<NULL>	7442	Effect of Supported Self-Care on adherence to oral anticoagulants	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3ms5dgd	<NULL>	Age 18 or older; both genders; Being treated with warfarin; Being under outpatient follow-up for blood clotting control; Presenting an unsatisfactory adherence score (&lt;6) on the Morisky Medication Adherence (MMAS-8); Having a landline or cell phone for teleconsultation; Presenting a satisfactory cognitive evaluation according to the application of the Mini-Cog© test	Participating in another study simultaneously; Pregnant women; Having any communication barriers that limit the implementation of the intervention and/or interviews. More than ten successive and unsuccessful attempts at telephone contact; Failure to show up for blood sample collection for INR assessment purposes for more than 2 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-8h6m9sx	The importance of an Exercise Program in the Aquatic environment for people with Back Pain and changes in sleep quality	Recruiting	Intervention	2024-10-19	<NULL>	<NULL>	7443	The influence of a Therapeutic Aquatic Exercise Program on individuals with Chronic Low Pain and changes in the quality of sleep	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-17	Centro de Ciências da Saúde  e do Esporte	Universidade Estadual de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8h6m9sx	<NULL>	Adults aged 18 to 65 years old;female and male; with a self-reported level of physical activity of moderate to advanced according to the International Quality of Life Questionnaire; with complaints of chronic low back pain for more than 3 months; with a pain threshold of at least 3 on the visual analogue scale; with overweight body mass index; 25.0–29.9 kg/m²	urinary and fecal incontinence; people who are undergoing pharmacological and physiotherapeutic treatments; specific for low back pain chronicle; during the present study; pregnant women; hypertensive patients without effective drug control and without drug treatment; Individuals who have open wounds; malaise such as; dizziness. nausea; vomiting; diarrhea and fever; people with severe heart disease; respiratory failure; deep vein thrombosis; uncontrolled epilepsy, generalized infection, skin ulcers, allergy to water products (for example: chlorine); people in;wheelchairs; with neurological problems and with hip prostheses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-5yzdx8g	Evaluation of the safety and efficacy of Doctive® lollipop in the treatment of Denture Stomatitis	Not yet recruiting	Intervention	2024-10-18	<NULL>	<NULL>	7439	Evaluation of the safety and efficacy of Doctive® for the treatment of Denture Stomatitis: a randomized double-blind clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-12-30	Faculdade de Odontologia da Universidade Federal de Goiás	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5yzdx8g	<NULL>	Patients using upper total dentures (PT) with a clinical diagnosis of Denture Stomatitis; over 18 years old; both sexes; with autonomy and ability to understand the purpose of the treatment and availability to voluntarily collaborate with the research	Patients allergic to any component of the DOCTIVE® formulation; immunocompromised; who have recently made continuous use of systemic or topical intraoral antifungals; patients who have recently made use of broad-spectrum antibiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-7y89mh3	Transcranial electrical stimulation can improve pain intensity, cardiac activity, brain and muscle activity in a person with low back pain	Not yet recruiting	Intervention	2024-10-18	<NULL>	<NULL>	7440	Effect of transcranial electrical stimulation pain parameters, cardiac variability, brain and muscle electrical activity for the treatment of chronic non-specific low back pain: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-09	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7y89mh3	<NULL>	Presence of non-specific low back pain confirmed by the roland morris disability questionnaire; age group over 18 years old; availability to attend the research site during the study period; both genders	Pregnant; person with seizure; pacemaker; open wound at the application site; cancer; deep vein thrombosis; epilepsy; spinal canal stenosis; radiculopathy; spondylolisthesis; scoliosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-2ngnynv	Effects of Functional Training on body and mind on the health of older people after the pandemic	Recruitment completed	Intervention	2024-10-18	<NULL>	<NULL>	7441	Impact of Functional Training on the physical and mental health of independent older people in the post-pandemic scenario	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2ngnynv	<NULL>	Be female. Age between 60 and 80. Not having participated in a systematic physical training program in the last six months. Not having had menstrual bleeding in the last twelve months. Not having musculoskeletal or cardiovascular contraindications to the practice of high-intensity physical training	Practicing physical exercises other than those proposed by the researchers during the study period. Presenting symptoms that make it impossible to practice the exercises prescribed in the study. Use of anti-inflammatory drugs during the period of the evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-6g5f4jz	Use of warm water in a plastic bucket and a hammock for babies admitted to hospital	Recruitment completed	Intervention	2024-10-16	<NULL>	<NULL>	7435	Hydrotherapy and redetherapy in hospitalized low birth weight preterm infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Santa Casa de Misericórdia de Sobral	Santa Casa de Misericórdia de Sobral	https://ensaiosclinicos.gov.br/rg/RBR-6g5f4jz	<NULL>	premature infants admitted to the Neonatal Intensive Care Unit and Neonatal Intermediate Care Unit; gestational age between 24 and 35 weeks; birth weight between 1,000 grams and 2,499 grams; 5 to 48 days old; complete enteral diet via orogastric tube	premature infants who have not completed the 15 days of therapy due to hospital discharge; food intolerance; clinical instability during the days of interventions; use of invasive or non-invasive mechanical ventilation or oxygen; neurological impairment; genetic syndromes diagnosed during the research; gastrointestinal disorders such as diarrhea or vomiting for three consecutive days; fasting on oral diet or breastfeeding; congenital infectious diseases; receiving phototherapy; peripherally inserted central venous access; surgery during hospitalizations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-3stmcdm	Auditory training with music in children with difficulties in learning and understanding sounds	Recruiting	Intervention	2024-10-16	<NULL>	<NULL>	7436	Musical auditory training in children with learning difficulties and Central Auditory Processing Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-3stmcdm	<NULL>	Be between 8 and 9 years old, have sufficient cognitive and linguistic skills to understand the tasks, Intelligible articulatory production, Audiometric thresholds within normal limits, present changes in at least one test from the minimum battery of the Central Auditory Processing assessment, suggested by the Brazilian Academy of Audiology as a criterion for diagnosing the disorder, present learning difficulties previously identified by the teacher and confirmed through a speech-language pathology assessment of reading and writing at the word level	Having undergone speech therapy, middle ear changes at the time of evaluation, be bilingual, frequently use a musical instrument, present evident or previously diagnosed neurological and emotional changes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-10gxfrdy	The effects of Dance for Breast Cancer patients after surgery	Recruiting	Intervention	2024-10-16	<NULL>	<NULL>	7437	The effects of Dance as a therapeutic resource for Breast Cancer patients undergoing surgical treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Fundação Antônio Prudente - AC Camargo Cancer Center	Fundação Antônio Prudente - AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-10gxfrdy	<NULL>	The study will include patients diagnosed with breast cancer; over 18 years old; who have undergone surgical resection; after medical prescription for physiotherapy; after physiotherapeutic evaluation	Patients with another previous oncological diagnosis; patients with previous neuromuscular diseases; patients who did not agree to take part in the study; patients unable to perform muscle strength or other assessments will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-44wxphd	Evaluation of a cosmetic for use in patients with Cancer in the prevention and treatment of Dermatitis caused by radiation	Recruiting	Intervention	2024-10-16	<NULL>	<NULL>	7438	Evaluation of an Oncological Cosmetic in the prevention and treatment of Radiodermatitis: a triple-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-27	Instituto do Câncer do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-44wxphd	<NULL>	Age over 18 years old; both sexes; diagnosis of breast cancer with indication of adjuvant radiotherapy treatment in the breast region; intact and continuous skin in the target region; first day of radiotherapy treatment (new cases); absence of previous history of radiotherapy in the same field/site of treatment; absence of previous treatment with chemotherapy, acceptance to participate in the research by signing the Informed Consent Form	Have hypersensitivity to one of the components of the research creams; patients with indication for electron radiotherapy; deficit in adhering to the research intervention and following the study guidelines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-6wf5hpt	Effects of Mirror Therapy on motor function of the paretic upper limb in chronic stroke	Data analysis completed	Intervention	2024-10-15	<NULL>	<NULL>	7432	Effects of Mirror Therapy on the motor function of the paretic upper limb of individuals affected by Stroke in the chronic phase	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Centro Educacional de Lavras	Centro Educacional de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-6wf5hpt	<NULL>	Age 18 years or older; clinical diagnosis of unilateral ischemic or hemorrhagic stroke;at least six months post-stroke; presenting with upper limb hemiparesis; no severe spasticity in the paretic upper limb (Modified Ashworth Scale score less than 4); no significant cognitive impairments (Mini-Mental State Examination score of 24 or higher for those with formal education, and 14 or higher for illiterate individuals);individuals with no visual impairments that would hinder their ability to observe movements in the mirror	Participants who missed more than 30% of Mirror Therapy sessions were excluded; individuals already receiving physiotherapy for their paretic upper limb were excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-7y8rwy4	Effectiveness of an intervention on risk factors for chronic non-communicable diseases in schoolchildren: PRATIQUE Health Project	Recruitment completed	Intervention	2024-10-15	<NULL>	<NULL>	7433	PRATIQUE Health Project	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-02	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-7y8rwy4	<NULL>	Adolescents of both sexes enrolled in elementary school II at public schools in the city of João Pessoa; age 10 to 15 years	Adolescents who do not answer the questionnaire correctly will be excluded; those who have any cognitive or motor or visual impairment that makes it impossible for them to answer the questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-10ncwk79	Intervention with walking and balance training using shoes and insoles combined with pain education in elderly women with knee osteoarthritis	Recruiting	Intervention	2024-10-15	<NULL>	<NULL>	7434	Therapeutic effect of balance and gait training with shoes and insoles associated with pain neuroscience education in elderly women with knee Osteoarthritis and history of COVID-19: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-31	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	https://ensaiosclinicos.gov.br/rg/RBR-10ncwk79	<NULL>	Elderly women between 60 and 80 years of age; female gender; medial femorotibial osteoarthritis diagnosed by X-ray; grade 2 and 3 knee osteoarthritis according to Kellgren and Lawrence criteria	Osteoarthritis of the hip and/or ankle; Disabling osteoarthritis of one or both knees; body mass index less than 35 kg/m2; vestibulo-cochlear diseases; uncontrolled cardiac and/or respiratory arrhythmias; convulsive syndrome; as well as musculoskeletal disorders such as diabetic neuropathies and tissue lesions (tegumentary ulcers of any etiology) that are functionally limiting; they may also not have prostheses and/or orthoses on their lower limbs or have fractures in the last 6 months; not present signs of dementia and walk independently; that is, maintaining a good general state of health so as not to bias the interpretations of the assessments involved; nor be receiving any other physiotherapeutic treatment during the intervention period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-27m45tt	The effect of Dental Bleaching on tooth sensitivity and quality of life	Recruiting	Intervention	2024-10-14	<NULL>	<NULL>	7427	Dental bleaching: dental sensitivity, psychosocial impact and impact on oral health-related quality of life using different desensitization protocols - a randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-03-24	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-27m45tt	<NULL>	Age between 18 and 40 years; patients without systemic diseases (metabolic, immunological, and heart diseases); oral condition without periodontal diseases; at least two canines with color C2 or darker, evaluated by the VITA classical A1-D4® shade guide; six upper anterior teeth free of restorations on the palatal and buccal surfaces; healthy enamel without pathological, physiological, and medication-induced alterations.	volunteers with orthodontic appliances; severe crowding; presence of intrinsic stains (tetracycline staining, fluorosis, non-vital teeth); using anti-inflammatory drugs; smokers; alcohol users; pregnant or breastfeeding women; participants who have already undergone whitening procedures; participants with bruxism or significant oral pathologies; participants with exposed dentin in the incisal portion of the anterior teeth; and with non-carious cervical lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-3vcy2qq	Modulation of pain, muscle function and viscoelastic properties through PENS in paralympic athletes	Not yet recruiting	Intervention	2024-10-14	<NULL>	<NULL>	7428	Improving the diagnosis of myofascial pain syndrome in athletes paralympics through the application of multiple parameters and the acute effects of Percutaneous Electrical Nerve Stimulation (PENS)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-20	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3vcy2qq	<NULL>	Paralympic athletes selected based on convenience and the evaluator’s judgment; athletes participating in sports with high physical demands on the upper limbs; both sexes; age over 18; having a myofascial trigger point being diagnosed through clinical examination; have participated in competitions at state level; national or international in the last year	Signs of cervical radiculopathy and positive Spurling test; severe cervical regenerative disc disease; direct trauma to the dorsal cervical region or shoulder in the last 90 days; major depression; suspected cancer; complete tear of the rotator cuff muscles; antiplatelet or anticoagulant therapies other than aspirin; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-44gh2w8	Light treatment to relieve pelvic floor pain in women	Recruiting	Intervention	2024-10-14	<NULL>	<NULL>	7429	Photobiomodulation in women with pelvic floor myofascial pain: a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-12	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-44gh2w8	<NULL>	Women with pelvic floor myofascial pain; age 18 and older; women who do not have cognitive dysfunction	Women reporting signs and symptoms of urinary tract infection; History of cancer, pelvic radiotherapy, or brachytherapy; Pregnant women or those trying to conceive; Use of analgesic, narcotic, and muscle relaxant medications; Grade III-IV genital prolapse (according to the Pelvic Organ Prolapse Quantification System (POP-Q)); Patients using photosensitive medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-5kgxp8s	Influence of Electrical Muscle Stimulation combined with strength training on motor capacity and quality of life in individuals undergoing hemodialysis treatment	Recruitment completed	Intervention	2024-10-14	<NULL>	<NULL>	7430	"Influence of Neuromuscular Electrostimulation combined with strength training on motor performance and quality of life in individuals undergoing hemodialysis treatment 
Hemodialysis"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-03	Santa  Casa de Misericórdia de Pelotas	Santa  Casa de Misericórdia de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-5kgxp8s	<NULL>	Participants in the study will be patients over the age of 18; of both sexes; who have been undergoing who have been undergoing hemodialysis through an arteriovenous fistula for at least 3 months; authorized by the nephrologist to participate	Participants with cognitive conditions (difficulty understanding the questions) that prevent them from understanding the items e;patients with pacemakers; sensory deficits; dystrophies; muscle ruptures (in the muscle to be treated); epilepsy; those with musculoskeletal impediments to walking muscle ruptures (in the muscle to be treated); epilepsy; those with musculoskeletal impediments to walking	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-35pt7vd	Effect of aromatherapy on sleep quality in elderly people	Recruiting	Intervention	2024-10-14	<NULL>	<NULL>	7431	Effect of aromatherapy on sleep quality in elderly people: double-blind, placebo-controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-35pt7vd	<NULL>	People of both sexes. Over 60 years of age who present changes in sleep according to the Pittsburgh Sleep Quality Index (PSQI) with a score ≥5. Be in a physical and cognitive condition to understand the Informed Consent Form and participate in the study by responding to the instrument: Pittsburgh sleep quality index (PSQI) and the sociodemographic and clinical questionnaire	Make use of other integrative practices to improve sleep quality. Have an allergy or intolerance to strong odors. Have irritation or lesions on the face. Have a history of known respiratory disorders, such as asthma, for example	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-58986zm	Cognitive rehabilitation program for patients with long COVID	Not yet recruiting	Intervention	2024-10-11	<NULL>	<NULL>	7424	Characterization of Neuropsychiatric, Neuropsychological, Radiological and Biological Findings of COVID-19 Infection in the Central Nervous System: a Cohort Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-18	Instituto de Psiquiatria da Faculdade de Medicina da Universidade de São Paulo	Núcleo de Inovação Tecnológica – InovaHC	https://ensaiosclinicos.gov.br/rg/RBR-58986zm	<NULL>	Individuals aged 18 or over, with a history of hospitalization due to COVID-19, who present complaints about their cognition demonstrated by performance below expectations in clinical assessments two years after hospital discharge.	Individuals with intellectual disabilities; individuals with severe visual and/or motor difficulties; and participants with less than eight hours of exposure to the game.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-8hqzb2g	Patient anxiety when being anesthetized for tooth extractions	Recruitment completed	Intervention	2024-10-11	<NULL>	<NULL>	7425	Patient Anxiety during Anesthesia in Oral Surgery; randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-29	Editora e Distribuidora Educacional S/A	Faculdade Anhanguera de Rondonópolis (FAR)	https://ensaiosclinicos.gov.br/rg/RBR-8hqzb2g	<NULL>	Healthy volunteers; both genders; non-smokers; age range between 20 and 45 years; in need of jaw extraction; signature on the free and informed consent form	Patients who use anxiolytics; uncontrolled systemic diseases; history of alcohol or drug abuse and patients who withdraw from the study at any time or who do not sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-8rp76n4	Use of Virtual Reality to relieve anxiety and fear before medical consultation in Pediatric Oncology: a randomized clinical trial	Data analysis completed	Intervention	2024-10-11	<NULL>	<NULL>	7426	Evaluation of the usability of a Virtual Reality Tool in the distraction of children and adolescents with Cancer during venous puncture	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2023-01-01	Hospital de Amor Infantojuvenil de Barretos	Hospital de Amor Infantojuvenil de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-8rp76n4	<NULL>	Patients between 7 and 16 years old; both sexes; who had their first appointment scheduled on an outpatient basis	Patients with visual and/or hearing deficits; patients with sensitivity to light; children with clinical conditions of nausea or vomiting when visually stimulated or very exacerbated at the time; patients with external shunts that prevent the use of the tool; patients with tumors in the head and neck region that are obstructive; patient diagnosed with epilepsy; patient or companion with cognitive impairment clinically assessed by the research team (impediment to completing the questionnaires and using the tool); patients who express anticipatory conditional generalized anxiety or untreated panic attacks; patients with clinical diagnoses of mental changes without pharmacological treatment assessed as impediment by the researcher; patients with a clinical diagnosis of Organic Brain Syndrome due to neurotoxicity (already treated or with some impeding deficit); Furthermore, if the researcher, when inviting the patient to the research, noticed that he was in intense pain and in need of medication intervention, she excluded the patient from the research and referred him to the Outpatient Intercurrence Center so that he could receive medical intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-42sf6c5	Brazilian study in children with spinal muscular atrophy	Recruiting	Observational	2024-10-10	<NULL>	<NULL>	7420	Brazilian observational study in children with SMA 5q (SOBRE5): effectiveness, safety and economic analysis of the use of the onasemnogen abeparvovec (Zolgensma) with real-world data	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-07	Hospital Universitário Professor Edgard Santos da Universidade Federal da Bahia	Hospital Universitário Professor Edgard Santos da Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-42sf6c5	<NULL>	Confirmed genetic diagnosis of Atrofia Muscular Espinhal 5q type 1 or type 2; have previously received or have a confirmed court order for the use of the onasemnogene abeparvovec-xioi (Zolgensma), even if older than 24 months	Inability to locate children based on the data provided by the Ministry of Health. No other exclusion criteria are anticipated	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-7h4zchf	Preoperative effect of 15 mg Melatonin on Anxiety, Pain, difficulty in mouth opening, Swelling, and Psychomotor Function in lower wisdom tooth Extraction: a randomized, double-blind, placebo-controlled clinical trial	Recruiting	Intervention	2024-10-10	<NULL>	<NULL>	7421	Effect of preoperative use of 15mg Melatonin on Anxiety, Pain, Trismus, Edema and Psychomotor Function in lower third molar Extraction: a randomized double-blind, placebo-controlled clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7h4zchf	<NULL>	Patients indicated for the extraction of at least one lower third molar (right or left); aged between 18 and 25 years; without systemic disease or who have a compensated systemic disease, classified as ASA I or ASA II (Classification by the American Society of Anesthesiologists); who agree to participate in the research in all its terms and sign the informed consent form (ICF)	Patients who routinely or daily use melatonin, anxiolytics, antidepressants, neuroleptics, or other drugs acting on the Central Nervous System; those allergic to melatonin, local anesthetics, or rescue medications that cannot be substituted due to the proper conduct of the study; those using Fluvoxamine; presence of psychiatric problems; blood pressure greater than or equal to 160x100 mmHg; pregnant and/or lactating women; classified as ASA III or ASA IV (Classification by the American Society of Anesthesiologists); surgeries exceeding 45 minutes after anesthetic infiltration; third molars classified as high difficulty; patients who withdrew their consent to participate in the research; patients who did not return for the seven-day postoperative follow-up or failed to submit the postoperative evaluation diary	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-288qb6h	Evaluation of a new portable test to help the diagnosis of tuberculosis	Recruiting	Observational	2024-10-10	<NULL>	<NULL>	7422	Evaluation of a complete technological solution (DNA extraction + qPCR) to help the diagnosis of tuberculosis at the point of care	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-04-01	Fundação Oswaldo Cruz	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-288qb6h	<NULL>	Be older than 18 years; be symptomatic suspecting of tuberculosis; to participate voluntarely; to produce at least 0.5 mL of sputum; both sexes shall be included	To have been previously infected with micobatérias não tuberculosas; not being able to produce the required sample volume	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-3z6krcg	Verification of Effort, Satisfaction and Performance of Children and Adolescents with Cerebral Palsy using Exergames	Recruiting	Intervention	2024-10-10	<NULL>	<NULL>	7423	Verification of the Level of Physical Effort, Satisfaction Index and Improvement in Performance of Children and Adolescents with Cerebral Palsy using Exergames	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3z6krcg	<NULL>	Children and adolescents with Cerebral Palsy; aged 10 to 21 years; of both sexes; Gross Motor Function Classification System (GMFCS) levels I to V; Manual Ability Classification System (MACS) levels I to V	Participants who are unable to understand and execute the intervention&apos;s specific instructions and commands will be excluded; withdrawal from participation or non-adaptation of the proposed intervention protocol; in case of absence and non-attendance of online sessions or those who have a technical failure in technological devices (computer/tablet)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-9k773yq	Effect of alginate/biocellulose dressings containing graphene and silver (Grafderm) and biocellulose with papain (Tecderm) on healing of diabetic ulcers	Recruitment completed	Intervention	2024-10-09	<NULL>	<NULL>	7414	Evaluation of alginate/biocellulose dressings containing graphene and silver (Grafderm) and biocellulose with papain (Tecderm) in the healing of diabetic ulcers: randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-10-02	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9k773yq	<NULL>	Diabetic patients; of both genders; outpatient clinics with neuropathic diabetic ulcers; aged between 18 and 80 years; with a maximum of 4 weeks of lesion development	Those with a known allergy to any of the components of the dressings; to possess ulceration with exposed tendon, periosteum or bone, bone infection (osteomyelitis acute) and soft tissue infection requiring treatment with systemic antibiotics; ulcer on a limb being considered for revascularization or debridement surgical; patients receiving medications (such as corticosteroids, immunosuppressants or chemotherapy) in the last six months before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-3tt2zhz	Comparison of recovery after addition of a medication to spinal anesthesia in patients undergoing uterine removal	Not yet recruiting	Intervention	2024-10-09	<NULL>	<NULL>	7415	Quality of recovery after hysterectomy surgery with the use of clonidine in spinal anesthesia	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-01-01	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3tt2zhz	<NULL>	age between 18 and 65 years; woman; underwent abdominal hysterectomy; american society of anesthesiology physical status 1 and 2	illiterate; contraindication to any medication used in the research; refusal to spinal anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-46dvfxf	Concentration of Brain-Related Proteins in the blood of adults with Autism and their relationship with neuropsychological tests	Recruiting	Observational	2024-10-09	<NULL>	<NULL>	7416	Evaluation of blood concentration of BDNF and proBDNF in adult patients diagnosed with Autism Spectrum Disorder and its correlation with neuropsychological assessment parameters in a brazilian population	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-46dvfxf	<NULL>	Adults aged between 18 and 65 years; previous diagnosis of Autism Spectrum Disorder (ASD) confirmed by a psychiatrist (for the ASD group);residents in Brazil; ability to provide informed consent, or having a legal representative capable of doing so in case of incapacity; availability to complete the Wechsler Adult Intelligence Scale, Beck Depression Inventory - Second Edition, Beck Anxiety Inventory, Autism Diagnostic Observation Schedule and Autism Diagnostic Interview-Revised instruments; willingness to provide biological samples for Brain-Derived Neurotrophic Factor (BDNF) analysis; both genders	Severe neurological or psychiatric conditions, such as schizophrenia or severe bipolar disorder; severe sensory or motor deficits; adults unable to consent and without a legal representative; ongoing medication treatments that may significantly influence behavior or cognitive responses; medical conditions that prevent safe collection of biological samples for Brain-Derived Neurotrophic Factor (BDNF) analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-2msy887	Body temperature regulation of elderly people who perform physical exercise in cold, temperate and hot environments	Recruiting	Observational	2024-10-09	<NULL>	<NULL>	7418	Behavioral thermoregulation during physical exercise in cold, temperate and hot environments: effects of aging	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-12-19	Departamento de Educação Física - Universidade Federal de Viçosa	Departamento de Educação Física - Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-2msy887	<NULL>	Both sexes; healthy;aged 18-30 and over 60 years old; physically active; no smokers; with normal cognitive function; with a reported absence of neurological diseases (including peripheral neuropathy and psychological diseases); with no use of medication (except oral contraceptives for women); with no cardiovascular and metabolic diseases; with eumenorrhea and no pregnancy (women)	By choice of the volunteer; exercise intolerance; intolerance or medical impediment to ingesting the temperature capsule; medical impediment of any nature	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-54k8gnf	Virtual Reality Applied to Autism	Terminated	Intervention	2024-10-09	<NULL>	<NULL>	7419	Effect of virtual reality training and coordinative exercises on cognitive, motor, and psychosocial parameters in children with mild autism spectrum disorder - ASD: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-10	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-54k8gnf	<NULL>	Individuals with mild ASD (Autism Spectrum Disorder); aged between 7 and 14 years; male gender	Children who present comorbidities such as ADHD (Attention Deficit Hyperactivity Disorder), OCD (Obsessive-Compulsive Disorder), epilepsy, and intellectual disabilities; three consecutive absences or 20% of the total required attendance; frequent tardiness that interferes with training progress; acquiring any illness that prevents exercise; withdrawal of the student/family; difficulties in understanding the procedures proposed by the researchers; presence of any other physical disability that prevents exercise; non-verbal children; participants whose parents do not have medical documentation confirming the diagnosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-9396ksd	Comparative study between Topical Coverages on critically colonized or infected wounds in patients with Pressure Injury	Recruiting	Intervention	2024-10-08	<NULL>	<NULL>	7410	Comparative study between Topical Coatings of Dialkyl Carbamoyl Chloride vs Polyamide with Silver	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-03-29	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9396ksd	<NULL>	Both sexes; patients aged between 18 and 80 years; pressure injuries requiring surgery (Grades 3 or 4); presence of critical colonization (positive tissue culture) or infection of wound (clinical and laboratory signs of infection); care by the Plastic Surgery Complex Wounds Group	Pressure injuries without surgical indication (Grades 1 or 2); presence of uncontrolled systemic disease; failure to collect intraoperative cultures; patients with BMI&gt;35; patients with diseases that compromise immunity; allergy to silver or dialkyl carbamoyl chloride acetate; non-agreement to participate in the study and/or sign the informed consent form; change of conduct; loss of follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-6r9jw7c	Effects of detraining and retraining on the health of the elderly	Data analysis completed	Intervention	2024-10-08	<NULL>	<NULL>	7411	Physical Exercise for promoting the health of older women	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6r9jw7c	<NULL>	Be over 60 years old; woman; active; participate in the university extension project	Be under 60 years old; sedentary; not participate in the university extension project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-9q8pknt	Non-contact Heart Rate Monitoring via Webcam during Rest and Virtual Reality Activities in people with Cerebral Palsy	Not yet recruiting	Intervention	2024-10-08	<NULL>	<NULL>	7412	Contactless Heart Rate Monitoring based on Photoplethysmography using Webcam during Rest and Virtual Reality Activities in People with Cerebral Palsy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	Escola de Artes, Ciências e Humanidade da Universidade de São Paulo EACH/USP	https://ensaiosclinicos.gov.br/rg/RBR-9q8pknt	<NULL>	Children and adults with Cerebral Palsy will be included in the study; of both sexes; with a minimum age of 5 years and no maximum age limit; with Gross Motor Function Classification System level I to V and Manual Skill Classification System level I to V	Participants unable to understand the activity; unable to carry out the instructions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-4kt27hp	Physiotherapeutic Exercises for pain, physical function and quality of life in people with Fibromyalgia	Recruiting	Intervention	2024-10-08	<NULL>	<NULL>	7413	Effect of a Rehabilitation Program on pain and functionality in people with Fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-07	Faculdade de Ciências da Saúde do Trairí da Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairí da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4kt27hp	<NULL>	Individuals of both sexes; aged between 18 and 75; living in the state of Rio Grande do Norte; people who have been clinically diagnosed with fibromyalgia	Individuals who have contraindications to exercise; individuals who are participating in another exercise programme or in another type of treatment at the same time; those who for some reason are unable to continue with the proposed intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-5sdqcgk	Minoxidil 1 mg oral versus Minoxidil sublingual 1 mg for the treatment of Female-pattern baldness: A randomized double blind clinical trial	Recruiting	Intervention	2024-10-07	<NULL>	<NULL>	7405	Minoxidil 1 mg oral versus Minoxidil sublingual 1 mg for the treatment of Female Pattern Alopecia: A randomized double blind clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-07-10	Hospital Moriah - Rede Moriah Saúde LTDA	Hospital Moriah - Rede Moriah Saúde LTDA	https://ensaiosclinicos.gov.br/rg/RBR-5sdqcgk	<NULL>	Female; Age between 18 and 55 years old; diagnosis of Female pattern hair loss classified on the Sinclair scale from III to IV	Previous treatment for hair loss in the last 6 months; hypertension; heart disease; nephropathy; other causes of hair loss or scalp dermatoses; adverse effects to treatments that prevent them from continuing the study ; Participant deprived of liberty by court or administrative decision, residing in a social or health care institution, under legal protection, without the capacity to express consent or comply with the requirements of the protocol ; Withdrawal of consent by the participant; Protocol violations or deviation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-6nwvfzd	Effectiveness of Needle and Self-adhesive electro-stimulation in men with Overactive Bladder Syndrome	Recruiting	Intervention	2024-10-07	<NULL>	<NULL>	7406	Eficacy of Percutaneous and Transcutaneous Eletroestimulation in men with Overactive Bladder Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6nwvfzd	<NULL>	Male volunteers; over eighteen years of age; diagnosed with overactive bladder syndrome; complaining of urinary urgency	Volunteers with neurological disease; with severe cognitive impairment; with a psychiatric diagnosis; with a cardiac pacemaker; with calculi; with urethral cysts; with an active lower urinary tract infection; diabetic volunteers with signs of peripheral neuropathy; volunteers taking anticholinergics; volunteers with infra bladder obstruction; with bladder cancer or with a metal plate in the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-6vmypw4	Use of Cashew Bark Extract in the treatment of Oral Lichen Planus	Recruiting	Intervention	2024-10-07	<NULL>	<NULL>	7408	Use of curcumin and Cashew Bark Extract in the treatment of Oral Lichen Planus: randomized controlled clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2023-07-01	Programa de Pós-Graduação em Ciências Odontológicas -  Universidade Federal do Rio Grande do Norte	Programa de Pós-Graduação em Ciências Odontológicas -  Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6vmypw4	<NULL>	Cases of patients with symptomatic lichen planus located on the oral mucosa; patients aged 18 or over; both genders; patients who are not treated for other diseases with systemic corticosteroids	Pregnant or lactating women; patients with asymptomatic Oral Lichen Planus  OLP; patients with a medical history of allergy to corticosteroids or hypersensitive to components of A. occidentale, such as phenols, or other plants from the Anacardiaceae Family; patients who received topical treatment for Oral Lichen Planus OLP two weeks before the start of the study; patients who received systemic treatment for Oral Lichen Planus -OLP four weeks before the start of the study; patients who do not show up for follow up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-83jyh6g	The effects of Behavioral Therapy associated with Electrotherapy of the Tibial, Parasacral and Medial Plantar Nerves on sleep quality in women with Urgency to Urinate: a randomized controlled clinical trial	Recruiting	Intervention	2024-10-05	<NULL>	<NULL>	7404	The impacts of Behavioral Therapy associated with Transcutaneous Electrostimulation of the Tibial, Parasacral and Medial Plantar Nerves on sleep quality in women with Urgent Urinary Incontinence: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-03	Faculdade de Educação Física e Fisiotrapia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-83jyh6g	<NULL>	Women over 18 years of age; women with complaints of urinary urgency; who may have UUI (Urgency Urinary Incontinence); MUI (Mixed Urinary Incontinence – urgency + stress); OBS (Overactive Bladder Syndrome); who obtain a score ≥ 8 on the Overactive Bladder – Validated 8 – Overactive Bladder Assessment Instrument (OAB-V8) questionnaire	Not knowing how to read and not being able to answer the questionnaires; having a urinary tract infection; not having undergone previous pelvic surgery with the exception of a Cesarean section; not having undergone previous pelvic radiotherapy; having a neurological disease; not undergoing pharmacological and physiotherapeutic treatment for OBS (Overactive Bladder Syndrome); having only SUI (Stress Urinary Incontinence) without UM (Urinary Urgency); having a diagnosis of obstructive sleep apnea and not accepting to participate in the research and/or not signing the TCLE (Free and Informed Consent Form)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-93s444p	Bedside Sitting and Respiratory Muscle Training for Critically Ill Intensive Care Unit ICU Patients	Recruiting	Intervention	2024-10-04	<NULL>	<NULL>	7401	Bedside Sedestation and Inspiratory Muscle Training for Critical Intensive Care Unit (ICU) Patients: A Randomized Clinical Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Hospital de Clínicas da Universidade Estadual de Campinas	Hospital de Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-93s444p	<NULL>	Patients over 18 years of age; of both sexes; who have been on invasive mechanical ventilation for a period of 5 days or more will be selected; patients must be hemodynamically stable and on low doses of vasopressor drugs; patients sedated with a Richmond Agitation Sedation Scale (RASS) score between 0 and -2; patients without sedation with a Glasgow Coma Scale score of 9 or higher; patients with adequate gas exchange and stable parameters: positive end-expiratory pressure (PEEP) &lt; 10 cmH2O, inspired oxygen fraction (FiO2) &lt; 0.6, oxygen saturation (SpO2) ≥ 90%	Patients who present the following contraindications for bedside sitting and inspiratory muscle training will be excluded from the study; patients who are hemodynamically unstable and on high doses of vasopressor drugs; patients with worsening gas exchange: inspired oxygen fraction (FiO2) greater than or equal to 0.5; patients with restrictions on changing position: spinal cord injury, increased intracranial pressure, need for logrolling, fractures that prevent sitting at the bedside; participants randomized to the control group, who during hospitalization present a reduction in maximum inspiratory pressure (≤30 cmH2O), will be excluded from the study to undergo inspiratory muscle training according to the institutional muscle training protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-7tym97d	Tranexamic Acid in the Treatment of Melasma: A Comparative Study of the Efficacy of Chemical Peeling Versus Microneedling	Recruiting	Intervention	2024-10-04	<NULL>	<NULL>	7402	Comparison of the Efficacy of Tranexamic Acid Peeling with Occlusion Versus Microneedling with Tranexamic Acid Solution for the Treatment of Melasma in Female Patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7tym97d	<NULL>	Woman; bilateral facial melasma; over 18 years old; user of SPF 50 sunscreen every 4 hours	Patients under 18 years of age; pregnant and lactating women; patients on any therapy with warfarin, heparin, aspirin or any other anticoagulant medication; patients on vitamin E therapy; patient on hormone replacement therapy or photosensitizing drugs such as tetracycline, spironolactone , phenytoin and carbamazepine; patient with hypersensitivity to the formulations used in the study; patients with bleeding disorders; patient with skin changes such as facial warts, active/recurrent herpes simplex, dermatitis and/or seborrheic, atopic and eczematous dermatosis; patient with a history of keloids or hypertrophic scars; immunocompromised patients; oncology patients; patients with a history of use of oral or topical retinoids, oral tranexamic acid, dermabrasion, laser, surgery, topical bleaching agents, chemical peels performed on the face in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-10bf7yj6	Photobiomodulation on tongue pressure and endurance	Recruiting	Intervention	2024-10-04	<NULL>	<NULL>	7403	Effects of Myotherapy associated with Photobiomodulation on tongue pressure and resistance in healthy individuals: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Fundação Percival Farqhuar (Universidade Vale do Rio Doce)	Fundação Percival Farqhuar (Universidade Vale do Rio Doce)	https://ensaiosclinicos.gov.br/rg/RBR-10bf7yj6	<NULL>	Participants of both sexes; aged between 18 and 35 years; brachycephalic or dolichocephalic facial type; no cognitive or structural alterations in the orofacial and cervical region; no neurogenic diseases; no oral lesions causing pain or discomfort; lingual frenulum attached to the middle third and to the sublingual caruncles. Participants who do not present contraindications to phototherapy, verified through a contraindication questionnaire for photobiomodulation (photosensitivity, pregnancy, glaucoma, undiagnosed lesion on or near the area to be irradiated, infection at the application site, history of cancer, use of a pacemaker or other electronic implant) will be included	Participants who do not complete all the proposed tasks; who do not tolerate the IOPI bulb in the oral cavity; who use medications that cause muscle weakness within 48 hours prior to data collection; and those with allergies to the materials used will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-3qb993t	Evaluation of the treatment of dentin sensitivity with diode laser and prophylactic desensitizing paste	Recruitment completed	Intervention	2024-10-04	<NULL>	<NULL>	7717	Evaluation of the use of Calcium and Sodium Phosphosilicate prophylactic paste and Diode Laser in the treatment of dentin hypersensitivity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-20	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3qb993t	<NULL>	Individuals meeting the following criteria will be included in the study: individuals of both sexes; aged between 18 and 40 years; presence of at least two teeth with non-carious cervical lesions and/or gingival recessions associated with symptoms of dentin hypersensitivity; presence of at least one hypersensitive tooth on each side of the dental arch, non-adjacent to each other; pain response equal to or greater than 4 on the Visual Analog Scale (VAS) following tactile stimulation; sensitivity response to air-blast stimulus corresponding to score 1 on the Schiff Cold Air Sensitivity Scale (SS); good general health status; and absence of known allergies to the products to be tested	Individuals meeting any of the following criteria will be excluded from the study: pregnant or breastfeeding women; continuous use or use within the previous six months of analgesics, psychotropic drugs, or anti-inflammatory medications; heavy smoking; presence of eating disorders or systemic conditions associated with chronic acid regurgitation; excessive dietary or environmental exposure to acidic agents; presence of oral pathologies capable of causing pain similar to dentin hypersensitivity; advanced periodontal disease; history of periodontal surgery, orthodontic treatment, desensitizing treatment, or dental bleaching within the previous 90 days; teeth presenting cracks or coronal fractures; teeth restored within the previous three months; extensively restored teeth and/or teeth with restorations extending to the experimental area; and teeth with fixed prostheses or serving as abutments for fixed or removable prostheses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:19
RBR-64mpg85	Effects of aerobic exercise associated with systemic laser in women with fibromyalgia	Recruiting	Intervention	2024-10-03	<NULL>	<NULL>	7396	Effects of an aerobic exercise protocol associated with systemic photobiomodulation on cardiorespiratory fitness, fatigue and functional capacity in women with fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Departamento de Biociências -Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-64mpg85	<NULL>	This study will include individuals of female sex; aged between 18 and 60 years; with a diagnosis of FM that will be scheduled by a specialized physician selected by the patient and later confirmed by a physical therapist who holds a doctorate and has eight years of experience in the area of Rheumatology taking into account the FM diagnostic criteria of the American College of Rheumatology Widespread Pain Index WPI greater or equal to 7 and Symptom Severity Scale ESS greater or equal to 5 or WPI of 4 to 6 and ESS score greater or equal to 9 widespread pain defined as pain in at least 4 of the 5 regions jaw symptoms and abdominal pain are not included in the definition of widespread pain and symptoms present for at least 3 months with cognitive capacity to understand the study according to the cut-off score of the Mini-Mental State Examination classified as slightly active and irregularly active according to criteria established by the International Physical Activity Questionnaire administered in its short version have a medical certificate allowing physical activity and interest in participating in the entire experimental protocol	Presence of uncontrolled systemic diseases, such as diabetes mellitus and systemic arterial hypertension; Neurological and musculoskeletal conditions that may directly interfere with the evaluations, such as paralysis, significant changes in sensitivity, advanced joint diseases (such as arthroplasties or osteoarthritis); Individuals who are malnourished (BMI &lt; 18.5 kg/m2) or morbidly obese (BMI ≥ 40 kg/m2); Absolute contraindication for photobiomodulation, such as the presence of neoplasia; Failure to present a medical certificate to perform physical exercise will prevent participation in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-5t8k6qz	Comic Books and the impact on adolescents&apos; Knowledge and Skills in Basic Life Support: a randomized controlled trial	Not yet recruiting	Intervention	2024-10-03	<NULL>	<NULL>	7397	Effectiveness of Comic Stories on the Knowledge and Skills of adolescents about Basic Life Support: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-04	Universidade Federal do PIauí	Universidade Federal do PIauí	https://ensaiosclinicos.gov.br/rg/RBR-5t8k6qz	<NULL>	Being a teenager; both genders; aged 10 to 19 years old	have professional training in the health area; have completed a Basic Life Support (BLS) course (less than 1 year ago); be expected to be away from work during the data collection period; have participated in the construction and validation stage of the Comic Book (HQ); have a self-reported limitation that makes it impossible to participate in the lecture class, in reading the Comic Book HQ or in developing Basic Life Support maneuvers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-5vmhdfs	HERNIACLINIC-Qol: database for Abdominal Hernia surgery data	Recruiting	Observational	2024-10-03	<NULL>	<NULL>	7398	HERNIACLINIC-Qol: Abdominal Wall Hernia surgery registry and database platform	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-01	Hospital Alemão Osvaldo Cruz	Hernia Clinic - Centro Especializado em Hérnia	https://ensaiosclinicos.gov.br/rg/RBR-5vmhdfs	<NULL>	All consecutive patients; male and female; age 18 years or older; undergoing abdominal wall hernia surgery at the Hospital Alemão Oswaldo Cruz Paulista and Vergueiro Units; operated by the surgeons participating in the research; who agree and sign the informed consent form	Under 18 years old; patients unable to assess and sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-59fb8f6	"Laser therapy associated with the unna boot in the treatment of people with 
leg wound: Randomized Clinical Trial"	Recruitment completed	Intervention	2024-10-03	<NULL>	<NULL>	7399	"Laser therapy associated with Unna Boot in the treatment of people with 
Venous Ulcer: Randomized Clinical Trial"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-27	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-59fb8f6	<NULL>	Be over 18 years old; male and female sex; medical diagnosis of venous ulcer or Ankle Brachial Index (ABI) between 0.6 and 1.3; treat with Unna Boot (BU) inelastic compressive therapy; be available to attend the health service or receive care at home at least once a week; make use of Unna&apos;s Boot	Present a mixed ulcer with Ankle Brachial Index &lt; (ABI) 0.5; peripheral arterial obstructive disease (PAOD); decompensated congestive heart failure CHF); acute rheumatoid arthritis; gestation; lesions suspected of being malignant; active bleeding and/or/clotting changes; septic phlebitis; massive deep vein thrombosis (DVT); some type of reported allergy to the therapeutic products used as treatment (coverings/dressings)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-8rwyp5g	Effects of an educational intervention aimed at Community Health Agents (CHA) about rights in maternal and child health	Data analysis completed	Intervention	2024-10-03	<NULL>	<NULL>	7400	Involving Users to Improve the Quality of Services and Guarantee Rights: strengthening the maternal and child health care system in the first 1000 days in Brazil (I WANT)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-11	Hospital Universitário da Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-8rwyp5g	<NULL>	Healthy volunteers. Both genders. At least 18 years old. Be a Primary Health Care professional in the municipalities of selection. Be a support network for pregnant women, women who have recently given birth and/or mothers of 2-year-old children. Be pregnant, have recently given birth and/or the mother of a 2-year-old child	Primary Health Care professionals who were on vacation, on leave and/or away for any reason. Pregnant women, puerperal women and/or mothers of children up to two years old who refused to participate voluntarily	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-7hwv8gj	Treatment stability and gum health with straight and braided upper bonded retainers 3 and 6 months post-treatment: Randomized Clinical Trial	Terminated	Intervention	2024-10-02	<NULL>	<NULL>	7392	Treatment stability and periodontal health with Straight and Multistranded Maxillary Fixed Retainers 3 and 6 months after treatment: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Uninga (Faculdade Inga)	Uninga (Faculdade Inga)	https://ensaiosclinicos.gov.br/rg/RBR-7hwv8gj	<NULL>	finished orthodontic treatment with satisfactory occlusal results; good periodontal health, all teeth irrupted up to the first permanent molar	medical condition with impact in the periodontal health, periodontitis, facial deformities, dental anomalies (shape and number)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-3dbxrc2	Prevention of Child Obesity in Primary Health Care of the metropolitan region of Vitória/ES	Data analysis completed	Intervention	2024-10-02	<NULL>	<NULL>	7393	Prevention of Child Obesity in Primary Health Care: a community essay in the metropolitan region of Vitória/ES	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-17	Centro de Ciências da Saúde - Universidade Federal do Espírito	Centro de Ciências da Saúde - Universidade Federal do Espírito	https://ensaiosclinicos.gov.br/rg/RBR-3dbxrc2	<NULL>	Families with children aged 7 to 10 years; both genders; registered in the Family Health Units of the four participating municipalities	Children with cognitive disabilities that make it impossible to answer the questionnaires and/or participate in educational activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-2k3zczn	Vaginal Massage by Hand or Device to Treat Women with Pain During Sex	Not yet recruiting	Intervention	2024-10-02	<NULL>	<NULL>	7394	Manual or Instrumental Perineal Massage to treat women with Sexual Pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-12-05	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-2k3zczn	<NULL>	Over 18 years; who has already experienced sexual intercourse with vaginal penetration; meets the Diagnostic and Statistical Manual of Mental Disorders criteria for genitopelvic on penetration pain disorder; and has pelvic floor muscles hypertonia verified by vaginal palpation	Women with diagnosed neuromuscular disease will be excluded; pregnant; symptoms of urinary tract infection at the time of assessment; pain triggered after a surgical procedure; already menopausal women; women who cannot tolerate perineal and intravaginal touch; previous trauma or fracture in the pelvic area; neurological or cognitive diseases that hinder or prevent a full understanding of the procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-10k3srtd	Subproject 2: Effectiveness of Mobile Application in Preventing Falls in the hospital	Not yet recruiting	Intervention	2024-10-02	<NULL>	<NULL>	7395	Effectiveness of Educational Technology to Prevent Falls in the hospital: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10k3srtd	<NULL>	Being 18 years of age or older; having been admitted to the institution for more than 12 hours; being literate; having a smartphone and/or another mobile device, such as a tablet; obtaining minimum scores in the Mini Mental State Examination, with the cut-off points: 21 for those with between one and three years of schooling, 24 for people with between four and seven years of formal education, and 26 for people with more than eight years of schooling	Patients with scheduled discharge; those with incapacitating mental illness; dementia; or those who present hemodynamic instability at the time of recruitment will be excluded; which will be assessed by assessing the patients&apos; vital signs, already carried out by professionals in the study sectors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-38mzf5k	Impact of jackfruit seed flour intake on glucose homeostasis and vascular health in humans	Recruiting	Intervention	2024-10-01	<NULL>	<NULL>	7389	Impact of acute and chronic intake of jackfruit seed flour on glucose homeostasis, endothelial function and intestinal microbiota in healthy and cardiometabolic risk individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-08	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-38mzf5k	<NULL>	Stage 2: healthy individuals of both sexes aged between 18 and 40 years. Stage 3: abdominal obesity as waist circumference greater than 102 cm for men and greater than 88cm for women; low levels (less than 40 mg/dL) of serum high-density lipoprotein cholesterol - HDL; hypertriglyceridemia as 150 mg/dL or higher; blood pressure of 130/85 mmHg or higher; and deficit in glucose homeostasis as fasting plasma glucose levels 100 mg/dL or higher; of both sexes; aged between 18 and 75 years old	Step 2: smokers; pregnant women; breastfeeding women; people with food allergies to flours, jackfruit, and its by-products, or any other food that will be offered; people taking drugs that interfere with the vascular system. Step 3: pregnant or breastfeeding women; human immunodeficiency virus (HIV) carriers; chronic corticosteroid users; those with food allergies to flour, jackfruit, and its by-products	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-7vgcwgz	Feasibility of walking training with Lokomat after severe Traumatic Brain Injury	Recruiting	Intervention	2024-10-01	<NULL>	<NULL>	7390	Effects of gait training on the Lokomat on improving gait and social participation in individuals after severe Traumatic Brain Injury (TBI): a feasibility study	<NULL>	4, single-arm-study, n/a	4	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal do Espirito Santo	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-7vgcwgz	<NULL>	Age between 18 and 50 years old; both sexes;  6 months to 3 years of Traumatic Brain Injury - TBI and classified as severe by the Glasgow Coma Scale (GCS) with a value of 3-8; have a walking speed of 0.2m/s to 0.6m/s assessed by the 10-meter Walk Test (WT10); provide informed consent prior to data collection	Weight over 135 kg. Height greater than 1.90 meters. Femur length less than 35 cm or greater than 47 cm. Unstable cardiovascular disease. Arterial hypertension. Acute myocardial infarction. Acute thromboembolic disease. Patients who have severe contractures in the lower extremities. Bone instability. Non-union fractures. Osteoporosis. Severe discrepancy in the length of the lower limbs. Osteomyelitis. Unhealed skin lesions. It has colostomy bags.  It has urinary tract catheters. Mechanical ventilation. Pregnancy. Infections. Inflammatory diseases. Uncontrolled chronic conditions. He suffered a stroke and spinal cord injury. Patient on hemodialysis. Patients who have already undergone training at Lokomat	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-6b83by6	Evaluation of oral health and saliva biomarkers in patients who undergo Stomach Reduction surgery: a clinical study	Recruiting	Intervention	2024-10-01	<NULL>	<NULL>	7391	Assessment of Caries and Periodontal Disease control, inflammatory markers and oral microbiota after Bariatric surgery: a randomized clinical trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de São Paulo (UNIFESP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-6b83by6	<NULL>	Adults. Both sexes. Severe or morbid obesity with surgical indication (body mass index higher or equal 35 kg/m2)	Chronic diseases other than obesity such as cancer, arthritis, asthma, neurological or neurodegenerative diseases. Chronic use of systemic or oral medications that interfere with salivary flow. Smoking. Alcoholism. Use of illicit drugs. Oro-dentofacial diseases. Facial/dental Trauma. Extensive tooth loss. Active carious lesions. Periodontal pockets larger than 3 mm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-7dcqstg	High and low intensity training on symptom severity and function in athletes with patellar tendinopathy	Recruiting	Intervention	2024-09-30	<NULL>	<NULL>	7388	High-load versus low-load resistance training on symptom severity and function in athletes with patellar tendinopathy: controlled, randomized, blinded clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-23	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	https://ensaiosclinicos.gov.br/rg/RBR-7dcqstg	<NULL>	Recreational athletes; male; aged eighteen to forty years; self reported localized pain in the patellar tendon; lasting three months or more; and greater than or equal to three on the ten point visual analogue scale during the single leg squat test on an inclined plane	Self report of uncontrolled chronic pathology; symptoms related to other knee dysfunctions; use of corticosteroid based medication; and unavailability to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-4q22z7y	Exploring medical education in Brazil: an investigation into anesthesiology competencies	Not yet recruiting	Intervention	2024-09-28	<NULL>	<NULL>	7387	Teaching anesthesiology competencies in Brazil: from general practitioners and family doctors to anesthesiology specialists	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-03-01	Hospital Universitário Gaffree e Guinle/HUGG da Universidade Federal do Estado do Rio de Janeiro - UNIRIO	Hospital Universitário Gaffree e Guinle/HUGG da Universidade Federal do Estado do Rio de Janeiro - UNIRIO	https://ensaiosclinicos.gov.br/rg/RBR-4q22z7y	<NULL>	Individuals of all genders aged over 18; for semi-structured interviews, participants must be physicians with a specialization or medical residency degree; for questionnaires on anesthesiology, socioeconomic, and professional profiles, participants must be physicians enrolled in a medical residency or specialization program; for the use of the teaching software, participants must be medical students between the eighth and twelfth periods or members of an anesthesiology academic league	Being a minor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-2sgn9cy	Effectiveness of educational software in the teaching-learning of nursing students on infant development	Not yet recruiting	Intervention	2024-09-27	<NULL>	<NULL>	7379	Effectiveness of Wise Infant Development® software in the acquisition of knowledge about infant development among nursing students: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal do Ceará	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-2sgn9cy	<NULL>	Both sexes; be at least 18 years old; be regularly enrolled in the educational institution; be a nursing student; not currently taking or having taken the child health course; have basic computer skills	Students absent due to medical leave or maternity leave; students who are already nursing technicians; obtain a score equal to or greater than 70% in the pre-test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-6cr3b2w	Short-term effects of different weekly frequencies of Strength Training on the Subjective Perceptions of Elderly People: A randomized crossover trial	Not yet recruiting	Intervention	2024-09-27	<NULL>	<NULL>	7380	Short-term effects of different weekly frequencies of Strength Training on Perceptive Responses of dwelling Elderly People: A randomized cross trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Universidade Federal Rural de Pernambuco	Programa Academia da Cidade, polo Cavouco	https://ensaiosclinicos.gov.br/rg/RBR-6cr3b2w	<NULL>	People of both genders; at least 60 years of age; have not practiced physical activity for at least six months; do not have disabling diseases that imply a risk for participating in the physical training program; do not have a diagnosis of cognitive impairments or mental health disorders that prevent them from understanding and assuming the commitments of the study	Participants who have a limiting health condition will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-3fnbr78	Evaluation of a Bioactive Gel for controlling Tooth Sensitivity after dental whitening using 6% Hydrogen Peroxide in adolescents	Not yet recruiting	Intervention	2024-09-27	<NULL>	<NULL>	7381	Evaluation of the effectiveness of a Bioactive Gel to control Dental Sensitivity after tooth whitening using 6% Hydrogen Peroxide in adolescents: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-23	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3fnbr78	<NULL>	Good general and oral health; ages between 12 and 16 years; both sexes; have at least six upper front teeth free of active caries and endodontic treatment; canines (13,23) should be A2 color or darker	Participants undergoing orthodontic treatment; use of dental prostheses; severe tooth discoloration (tetracycline stains, fluorosis or devitalized teeth; pregnant and lactating women; patients who have already undergone tooth whitening	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-9bsr5n4	A Distance Rehabilitation Proposal for Women with Knee Arthrosis	Recruitment completed	Intervention	2024-09-27	<NULL>	<NULL>	7382	A proposal for Telerehabilitation of Women with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade de São Paulo	Faculdades Integrada de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-9bsr5n4	<NULL>	Women; aged between 55 and 85; with a self-reported medical diagnosis and X-ray examination of knee osteoarthritis; with internet access; via wifi or 3G to 5G connection on smartphone, tablet or computer; and who had no indication for knee joint replacement surgery	Women without a medical diagnosis of knee osteoarthritis; with a history of knee joint surgery or with an indication for joint replacement; who declared that they did not have access to the internet; had any cognitive dysfunction or declared any impediment to participating during the requested period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-2nvf88f	Education on the management of drugs in the emergency car	Recruitment completed	Intervention	2024-09-27	<NULL>	<NULL>	7383	Management of drugs in the emergency car: an experimental study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-20	Residência em Enfermagem em Urgência e Emergência	Hospital Universitário da Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-2nvf88f	<NULL>	Volunteers aged 18 or over; working in the emergency department of the research institution; agreed to take part in the study and signed the informed consent form	Volunteers who were absent from work during the data collection period due to vacation, leave and/or any other reason. Volunteers who were absent or withdrew at any stage of the research were also excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-5wr5kw5	The effects of Dry Needling on Delayed Muscle Pain in healthy women	Not yet recruiting	Intervention	2024-09-27	<NULL>	<NULL>	7384	The effects of Dry Needling on Delayed Muscle Pain in healthy women:  a sham-controlled randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-25	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	https://ensaiosclinicos.gov.br/rg/RBR-5wr5kw5	<NULL>	Feminine gender; be between 18 and 28 years of age; considered active according to the characterization of the International Physical Activity Questionnaire Short Version (IPAQ); perform physical activity involving upper limbs at least twice per week; present integrity of the shoulder, elbow and hand joints of the member non-dominant; no history of musculoskeletal injury in the assessed limb, in the last 6 months, nor neurological, visual and/or auditory deficits adjusted; no regional sensitivity disorder; do not use anticoagulants; not have needle phobia; no previous experience using dry needling	Not correctly carrying out assessment procedures; do not attend any stages of the research; carry out another type of intervention for muscle recovery during the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-68m8zh2	Neuromuscular Electrostimulation and Phototherapy in the prevention and treatment of Muscular Loss	Recruitment completed	Intervention	2024-09-27	<NULL>	<NULL>	7385	Association of Neuromuscular Electrostimulation and Photobiomodulation in the prevention and treatment of Sarcopenia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-30	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-68m8zh2	<NULL>	Elderly females; over 60 years old; with normal cognition	Male subject; aged under 60 years; with musculoskeletal injuries; cognitive impairment; chronic diseases such as uncontrolled hypertension, diabetes, neoplasms and kidney diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-10fpnsh5	Risk scores Respiratory Risk Assessment in Surgical Patients in Catalonia - ARISCAT, American Society of Anesthesiologists - ASA, Local Assessment of Ventilatory Management During General Anesthesia for Surgery - LAS VEGAS and the incidence of postoperative pulmonary complications in patients undergoing thoracic surgery	Not yet recruiting	Observational	2024-09-27	<NULL>	<NULL>	7386	ARISCAT, ASA and LAS VEGAS risk scores and the incidence of postoperative pulmonary complications in patients undergoing thoracic surgery with single-lung ventilation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-11-01	Hospital Nossa Senhora da Conceição - Grupo Hospitalar Conceição	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-10fpnsh5	<NULL>	All patients over 18 years of age; both genders;  undergoing non-cardiac thoracic surgery and with single-lung ventilation	Patients undergoing thoracic cardiac surgeries; patients under 18 years of age; pregnant women; patient refusal; contraindications to the proposed surgical, anesthetic or analgesic techniques; sepsis; psychiatric illness; uncontrolled endocrine, renal or hepatic disease; coagulopathies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-10svdw4c	Treatment of Dentin Hypersensitivity using a nanoparticle-based Fluoride Solution	Recruiting	Intervention	2024-09-26	<NULL>	<NULL>	7373	Treatment of Dentin Hypersensitivity using a Silver nanoparticle-based Fluoride Solution: randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-10	Anhanguera - UNIDERP (Universidade para o Desenvolvimento do Estado e da Região do Pantanal)	Anhanguera - UNIDERP (Universidade para o Desenvolvimento do Estado e da Região do Pantanal)	https://ensaiosclinicos.gov.br/rg/RBR-10svdw4c	<NULL>	Elderly people aged 60 and 80; both sexes; healthy people who do not have a known allergy to any of the components of the materials studied; have good oral and gum health; present dentin hypersensitivity in the exposed root region (gingival recession clinically detected by periodontal probe greater than or equal to 3 mm); dentin hypersensitivity greater than 7 on a scale of 0-10	Patients with caries lesions; periodontal disease; dentin hypersensitivity greater than 7	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-73xfytr	Pilates in Patients with Knee Osteoarthritis	Recruiting	Intervention	2024-09-26	<NULL>	<NULL>	7374	Pilates in Patients with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-73xfytr	<NULL>	Clinical diagnosis of Knee Osteoarthritis following the criteria of the American College of Rheumatology; radiological changes from grade 2 according to the criteria described by Kellgren and Lawrence; presence of pain measured by the numerical scale of pain from level; both sexes	Asymptomatic knee osteoarthritis; previous surgery in the lower limbs; neurological disorders; inflammatory disorders; infectious disorders; traumatic disorders; severe visual disturbances; use of prosthesis or orthosis in the lower limbs; lack of comprehension of the Portuguese language; who have undergone physical therapy treatment in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-6tnqpjm	Prevention of Bone Necrosis induced by Radiotherapy in the oral cavity region with the drug combination of Pentoxifylline and Tocopherol: randomized clinical trial	Recruiting	Intervention	2024-09-26	<NULL>	<NULL>	7375	Prevention of Osteoradionecrosis of the jaw with the drug combination of Pentoxifylline and Tocopherol: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-15	Sociedade Pernambucana de Combate ao Câncer	Sociedade Pernambucana de Combate ao Câncer	https://ensaiosclinicos.gov.br/rg/RBR-6tnqpjm	<NULL>	Older than 18 years; both genders; presence of teeth requiring extraction; history of radiotherapy to the head and neck with at least 40Gy to the maxilla and/or jaw; more than 3 months after the end of head and neck radiotherapy	Patients known to be allergic to pentoxifylline or tocopherol; individuals with systemic impairment that contraindicate the surgical procedure; patients undergoing palliative treatment, with no indication for surgical intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-2bgcvwj	Intravitreal injection of dexamethasone disodium phosphate as a predictor of response to intravitreal dexamethasone implant in diabetic macular edema refractory to anti-VEGF therapy	Not yet recruiting	Intervention	2024-09-26	<NULL>	<NULL>	7376	Intravitreal injection of dexamethasone disodium phosphate 2 mg/mL as a predictor of response to dexamethasone 0.7 mg intravitreal implant in diabetic macular edema refractory to anti-VEGF therapy	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2bgcvwj	<NULL>	(1) age 18 years or older; (2) diagnosis of diabetes mellitus for at least 5 years; (3) presence of refractory diabetic macular edema defined as central macular thickness (diabetic macular edema [DME]) &gt;300 μm caused by intraretinal or subretinal fluid and a &lt;10% reduction in DME from baseline 1 month after at least three monthly intravitreal anti-VEGF (bevacizumab, ranibizumab, or aflibercept) injections, as measured by spectral-domain optical coherence tomography (SD-OCT); (4) best-corrected visual acuity (BCVA) between 1.3 (20/400) and 0.2 (20/32) LogMAR; and (5) history of uncomplicated ipsilateral cataract surgery with intraocular lens implantation; (6) both genders	(1) any diabetic macular edema (DME) treatment in the last 4 months; (2) panretinal photocoagulation (PRP) in the last 6 months; (3) any ophthalmic surgery performed in the last 4 months; (4) history of pars plana vitrectomy (PPV); (5) history of open-angle glaucoma or corticosteroid-induced elevated intraocular pressure requiring antiglaucoma or antihypertensive ocular treatment; (6) intraocular pressure &gt;= 21 mmHg; (7) history of allergy to any product used in the procedure; (8) presence of tractional retinal detachment affecting the fovea	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-26cnqdt	Effect of resistance training with different exercises on muscle strength and selective hypertrophy of the quadriceps femoris	Not yet recruiting	Intervention	2024-09-26	<NULL>	<NULL>	7377	Chronic effect of different exercises on strength and selective hypertrophy of the quadriceps femoris	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-01-06	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-26cnqdt	<NULL>	Men; university students; aged between 18 and 35 years; body mass index less than 30 kg/m2; physically active; no restrictions on the practice of physical exercise; with previous experience in resistance training but who have not been training in the last six months; no history of osteomyoarticular injury of the lower limbs in the last twelve months; who have not used any ergogenic resource in the last twelve months	Subjects who do not achieve 85% adherence to training sessions; use supplements; engage in other high-intensity counter-resistance activities during the experimental period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-7dqn5mm	The ear test program from the perspective of family members and professionals: analysis of the satisfaction and impact of an educational intervention	Recruiting	Intervention	2024-09-26	<NULL>	<NULL>	7378	The neonatal hearing screening program from the perspective of family members and professionals: analysis of satisfaction and the impact of an educational intervention	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-03	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7dqn5mm	<NULL>	Pregnant and postpartum women; cared at Januário Cicco Maternity School; with or without risk indicators for hearing impairment;  with or without newborn hearing screening.	Refusal to participate in the study; individuals under the age of 18; did not complete the questionnaires; pregnant women in the first trimester of pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-8p68t8d	Effect of different intensities of aerobic training on sleep disorders and mental health	Recruiting	Intervention	2024-09-24	<NULL>	<NULL>	7370	Effect of different intensities of aerobic training on Obstructive Sleep Apnea and mental health variables	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-30	Escola Superior de Educação Física da Universidade de Pernambuco	Escola Superior de Educação Física da Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8p68t8d	<NULL>	"As inclusion criteria, participants must have a diagnosis of Obstructive Sleep Apnea (snoring, breathing stops and daytime sleepiness) proven by a polysomnography (PSG) test; participants will not be able to meet the minimum recommendations for physical activity in the last three months (at least 150 minutes of light to moderate activity or 75 minutes of vigorous activity) as assessed by a questionnaire; in addition, participants will be included in the study who do not have a medical history of resistant hypertension, cerebrovascular disease, arrhythmias, pacemakers, fibrillation, congestive heart failure, heart disease, emphysema, known ischemic cardiovascular disease, peripheral obstructive arterial disease, renal failure, serious medical problems such as neurological, psychological or cooperation problems that would prevent successful participation in the exercises;
male and female participants will be included; between the ages of 18 and 60"	Participants who do not complete the protocol of at least 80% of the scheduled training sessions in the experimental group and who use sleeping medication will be excluded; participants who have not been diagnosed by a doctor specializing in mental health, but who exhibit anxiety or depression that compromises their participation in the study, will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-8mj25hx	Nanotechnology eye drops for the treatment of dry eye: a multicenter and prospective study	Data analysis completed	Intervention	2024-09-24	<NULL>	<NULL>	7371	Phospholipid nanoemulsion-based ocular lubricant for the treatment of dry eye subtypes: a multicenter and prospective study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-30	Cetos, Pesquisa Diagnóstico e Tratamento Oftalmológico LTDA	Cetos, Pesquisa Diagnóstico e Tratamento Oftalmológico LTDA	https://ensaiosclinicos.gov.br/rg/RBR-8mj25hx	<NULL>	Participants 18 years of age or older of both sexes; Ability to understand and analyze the free and informed consent form; Able and willing to attend all study visits; Present a TFBUT bigger than 5 seconds in at least one eye; Dry eye symptoms with Ocular Surface Disease Index questionnaire bigger than 13 points; Present at least one of the 3 criteria below in at least one of the eyes: Schirmer test score I less than 9 mm; Meibomian transparency quality score bigger than 1 (on a scale of 0 to 3) or meibomian gland expressibility score bigger than 1 (on a scale of 0 to 3); Patients who completed the competitions mentioned in the first 2 items; Best corrected visual acuity bigger than 20/80 in both eyes; Have mild to moderate dry eye; Be willing to discontinue use of all artificial tear supplements and only use the study product as directed throughout the entire duration of the study	Patients who meet any of the criteria listed below during the screening visit will be excluded from participation in this study: History of hypersensitivity to the study drug or any component related to the study product; Use of any topical ocular medication preserved with benzalkonium chloride or other product known to be toxic to the tear lipid layer one month prior to the study screening visit; Start of eye hygiene 4 weeks before the screening visit; History of malignancy in any organ treated or not within an interval of less than 5 years; Eye abnormalities that may compromise the safety and effectiveness of treatment, such as: Eyelid abnormalities that compromise blinking and complete eyelid closure; Corneal diseases such as ulcers, abrasions, keratoconus or dystrophies, which may be active or affect vision; Metaplasia of the ocular surface; history of recurrent corneal erosion; evidence of corneal neovascularization; history of herpes simplex keratitis or zoster; uncontrolled systemic disease; eye infection; participation in any clinical study less than 30 days prior to the screening visit; tear punctum plug insertion or any procedure 30 days prior to the screening visit; initiation of use or change in dose of systemic medications (antihistamines, anti-depressants, anti-psychotics and benzodiazepines) that may cause dry eye 30 days before the screening visit; use of contact lenses within one week of the screening visit; history of ocular surgeries within 6 months prior to the screening visit; start of any topical ocular medications 2 weeks prior to treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-6gnf5pn	Influence of menthol on shortness of breath and exercise tolerance in endurance athletes	Recruitment completed	Intervention	2024-09-24	<NULL>	<NULL>	7372	Influence of menthol on dyspnea and exercise tolerance in endurance athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-04	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6gnf5pn	<NULL>	Be healthy; not to make regular use of medications or supplements; not being a smoker; be a high-performance athlete; be between 18 and 35 years; of both genders	Be under 18 years old and over 35 years old; not being a high-performance endurance athlete	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-6rgr4gp	Chest physiotherapy in infants with Acute Viral Bronchiolitis	Data analysis completed	Intervention	2024-09-23	<NULL>	<NULL>	7366	Phydiotherapeutic intervention in infants with Viral Bronchiolits moderate acute	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-19	Complexo do Hospital de Clínicas da Universidade Federal do Paraná	Complexo do Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6rgr4gp	<NULL>	Infant patients; of both sexes; from 1 day of life to 12 months of age; admitted to the pediatric wards at the Hospital de Clínicas do Complexo Hospital de Clínicas; with no history of hospitalizations; with a clinical diagnosis and classified as moderate in the Acute Viral Bronchioitis score; which guardians agree to adhere to the Informed Consent Form	Infants who present hemodynamic instability; classified as mild or severe in bronchiolitis scores; prematurity; lung malformation; bronchopneumonia; congenital heart defects; with a history of hospitalizations for other pathologies; refusal of family members or guardians and failure to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-7b4whmz	Different teaching strategies about patient safety goals for nursing and medicine students	Recruiting	Intervention	2024-09-23	<NULL>	<NULL>	7367	Assessment of the effectiveness of different teaching strategies on patient safety for nursing and medicine students in primary health care: randomized controlled study	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-11-24	Faculdade de Medicina da Universidade Federal de Juiz de Fora	Faculdade de Medicina da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7b4whmz	<NULL>	Volunteer students who must be regularly enrolled in the 9th period of the medicine and nursing course at the Federal University of Juiz de Fora; be over 18 years of age; both sexes;  and agree to participate in the study	Students from both courses who are absent; licensed or on leave during the data collection period and who do not sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-99h2qmf	Effect of Vitamin E in pregnant women with Severe Preeclampsia	Not yet recruiting	Intervention	2024-09-23	<NULL>	<NULL>	7369	Vitamin E Supplementation in pregnant women with Severe Preeclampsia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Departamento de Análises Clínicas e Toxicológicas	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-99h2qmf	<NULL>	Pregnant women aged ≥ 18 years, diagnosed with severe preeclampsia, defined as systolic blood pressure ≥160 mmHg and/or diastolic blood pressure ≥110 mmHg or the presence of other clinical and laboratory alterations, such as: severe headache, chest pain, dyspnea, O2 saturation &lt;97%, leukocytosis, thrombocytopenia, elevated creatinine and uric acid, nausea, vomiting, epigastric pain, elevated bilirubin, plasma albumin, low non-reactive cardiotocography, oligohydramnios, umbilical artery Doppler with absent or reversed dialysis flow, will be included. The inclusion criteria also include pregnant women with inadequate levels of serum alpha tocopherol (≤ 30 mmol), from the 20th gestational week, with a single fetus and followed up at the high-risk multidisciplinary prenatal outpatient clinic at the Januário Cicco Maternity Hospital	Women with a previous or current diagnosis of Diabetes Mellitus or Gestational Diabetes Mellitus, cases of multiple pregnancies, pregnant women who smoke, have allergies or are taking supplements containing vitamin E above 50 IU, who are using illicit drugs or alcohol during the current pregnancy, have fetal abnormalities, have documented uterine bleeding within one week of screening, have pregnancies resulting from in vitro fertilization, have thrombophilia, are carriers of Human Immunodeficiency Virus, syphilis and systemic lupus erythematosus will be excluded from this study. Women with serum tocopherol levels &gt; 30 mmol/L and whose delivery does not take place at the Januário Cicco Maternity Hospital will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-4bv89x8	Effect of a prenatal program on child development among babies exposed to Covid-19 in utero	Data analysis completed	Intervention	2024-09-21	<NULL>	<NULL>	7364	Exposure to SARS-Cov-2 and child development in the first year of life	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-15	Instituto de Ensino e Pesquisa Alberto Santos Dumont	Universidade Estadual de Campinas -UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-4bv89x8	<NULL>	Inclusion criteria for both groups included singleton pregnancies followed at the Anita Garibaldi Health Center; minimum age 18 years; absence of confirmed or suspected fetal congenital infection or chromosomal anomalies; no serious illness or complications during pregnancy; and no substance use disorder	Failure to complete the follow-up during the first year after birth at the clinic; neonatal death; and extremely preterm (less than 28 weeks) or very preterm (less than 32 weeks) infants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-36q469s	Effects of Healthy Eating on Constipation in Parkinson&apos;s Disease	Recruiting	Intervention	2024-09-21	<NULL>	<NULL>	7365	Effects of the Mediterranean Diet on Constipation in Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-05	Hospital Ophir Loyola	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-36q469s	<NULL>	Parkinson Disease patients; constipation symptoms according to the bristol scale types 1 and 2 and diagnosis of chronic constipation according to the Rome III criteria; age over 18 years old; agree to participate in data collection and sign the free and informed consent form (TCLE)	Patients diagnosed with dementia associated with Parkinsoon Disease, according to the criteria of the movement disorders society task force; history of other neurological diseases, with associated and diagnosed psychiatric illnesses; use of oral laxative medicatios, enemas and laxative suppositories during the study; use of antibiotics one month before the initial assessment; diagnosis or history of inflammatory and neoplastic gastrointestinal diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-66gdhfm	Analysis of clinical and laboratory variables to create a score for the indication of invasive mechanical ventilation in patients with COVID-19	Recruitment completed	Observational	2024-09-20	<NULL>	<NULL>	7360	Analysis of clinical and laboratory variables to create a score for indicating invasive mechanical ventilation in patients with suspected and/or confirmed covid-19	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-03-01	Hospital Universitário Pedro Ernesto	Hospital universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-66gdhfm	<NULL>	The inclusion criteria will be individuals with suspected or clinical diagnosis of COVID-19, with a minimum hospital stay of 24 hours and submitted to oxygen therapy or non-invasive ventilation. The research protocol will be in accordance with Resolution 466/12 and will be forwarded to the Ethics and Research Committee of HUPE - CEPq, via Plataforma Brasil, and all research participants will sign the Free and Informed Consent Term and the Commitment Term of data usage.	Exclusion criteria for participation in the study will be as follows: (1) patients under 18 years of age; (2) patients with a negative laboratory test for COVID-19; (3) patients requiring emergency intubation; (4) patients who underwent previous endotracheal intubation in the same hospitalization.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-7dz5y9x	Clinical potential of the product Desplac (Premium Oral Gel) in the prevention of Gingivitis and as an adjunct to scaling and root planing therapy	Recruitment completed	Intervention	2024-09-20	<NULL>	<NULL>	7361	Clinical and microbiological potential of the product Desplac (premium oral gel) in the prevention of Gingivitis and as adject to Scaling and Root Planning Therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-03	Universidade Guarulhos - UNG	Universidade Guarulhos - UNG	https://ensaiosclinicos.gov.br/rg/RBR-7dz5y9x	<NULL>	Men and women; between 18 and 65 years of age; good general health (absence of any condition that may constitute a risk to the subject during participation in the study, examples: heart problems, chronic kidney problems, etc.); willingness to provide information related to their medical history; minimum of 15 permanent natural teeth without crowns (excluding third molars); average initial gingivitis index of at least 1.5, as determined by use of the gingival index; present generalized periodontitis Stages II or III, Grades A or B, based on the criteria established by the American Academy of Periodontology (2018)	Presence of orthodontic bands; presence of removable partial dentures; oral pathology, chronic disease or history of allergy to the active principles of dentifrices; use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication, or daily analgesics within one month of starting the study or scheduled to start such intake during the course of the study; pregnant or breastfeeding women; allergy to oral care products, personal care products or their ingredients; prolonged use of antibiotics or therapeutic mouthwash at any time during the three months prior to study entry; need for prophylaxis with antibiotics; ongoing use of medications known to affect gingival tissues (ie, calcium channel blockers, phenytoin, cyclosporine); periodontitis (purulent exudate, tooth mobility and/or extensive periodontal attachment loss); probing depth greater than 4 mm; periodontal treatment in the last 12 months before the beginning of the study; smokers (at least 10 cigarettes/day for at least 5 years) and former smokers (at least 5 years ago); history of periodontal treatment in the last six months; continuous use of oral antiseptics; use of systemic antibiotics, corticoids, non-steroidal anti-inflammatory drugs, immunosuppressants, estrogen and estrogen receptor modulators, as well as drugs that may influence bone metabolism (alendronate, calcitonin and others) in the last six months; systemic disease that may alter host response to periodontal treatment (eg diabetes) or that requires prophylactic medication for dental treatment (eg mitral valve prolapse); allergy to oral care products, personal care products or their reporting ingredients; use of orthodontic appliances, and extensive prosthetic rehabilitations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-55wvt6s	Effectiveness of Non-invasive Neuromodulation associated with virtual gaming in women with Fibromyalgia	Recruitment completed	Intervention	2024-09-19	<NULL>	<NULL>	7356	Effectiveness of Transcranial Direct Current Stimulation (tDCS) associated with Virtual Reality in women with Fibromyalgia: a clinical study randomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-18	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-55wvt6s	<NULL>	Female individuals who agreed to participate in the study by agreeing to a Free and Informed Consent Form (TCLE); aged between 30 and 50 years old; and had a clinical diagnosis of Fibromyalgia	Exclusion criteria considered were to female individuals who did not understood or were unable to carry out the proposed activities; patients with cardiac arrhythmias and atrioventricular block; congenital anomalies; lung malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-8h6tk9z	Evaluation of the use of Auriculotherapy to improve pain in Tumor Wounds in patients undergoing palliative care	Not yet recruiting	Intervention	2024-09-19	<NULL>	<NULL>	7357	Evaluation of the effects of Auriculotherapy to control pain in lesions or tumor wounds in patients with advanced cancer undergoing palliative care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-03	Instituto Nacional do Câncer	Instituto Nacional do Câncer	https://ensaiosclinicos.gov.br/rg/RBR-8h6tk9z	<NULL>	Patients of both sexes in palliative care enrolled at the Cancer Hospital Unit Four (HCIV); patients with pain symptoms of a minimum intensity of four points on the Edmonton Symptom Assessment System (ESAS) scale in the wound/tumor lesion (LFT) located in the skin, breast, head and neck, genitals, rectum or anal canal; patients with FLT staging record (1, 1N, 2, 3 and 4); patients at least 20 years old; patients with (KARNOFSKY PERFORMANCE STATUS SCALE (KPS) greater than 30%, therefore responsive; patients agreeing to sign the Informed Consent Form (ICF)	Patients with injuries to both ear pinnae; patients with adhesive plaster allergy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-3vkjyvy	Efficiency of weight loss support for patients with excess body weight and other diseases that pose a risk to heart health	Data analysis completed	Intervention	2024-09-19	<NULL>	<NULL>	7358	Effectiveness of a weight loss program for obese patients with cardiovascular risk factors	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Instituto Dante Pazzanese de Cardiologia do Estado de São Paulo	Instituto Dante Pazzanese de Cardiologia do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3vkjyvy	<NULL>	Being a patient at the Dante Pazzanese Institute of Cardiology-SP; of both genders; be aged ≥ 19 years; agree to participate in the study and have consented and signed the informed consent form	Pregnant patients; patients with liver disease; in the pre-transplant period; diagnosed with chronic kidney disease; oncology, diagnosed with heart failure; atrial fibrillation; with pacemakers and with bundle branch block	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-4mzhbd3	Accelerated protocol of Non-Invasibe Neuromodulation for Pain control	Recruiting	Intervention	2024-09-19	<NULL>	<NULL>	7359	Accelerated protocol of Repetitive Transcranial Magnetic Stimulation for Chronic Musculoskeletal Pain control	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-01-01	Instituto Multidisciplinar de Reabilitação e Saúde - Universidade Federal da Bahia	Hospital Universitário Pedro Ernesto / UERJ	https://ensaiosclinicos.gov.br/rg/RBR-4mzhbd3	<NULL>	Adult individuals aged 18 or over; both genders; with musculoskeletal-origin Chronic Pain, diagnosed by a specialist physician for at least three months, and with a pain intensity greater than 4/10 on the Visual Analog Pain Scale (VAS)	Participants with diagnosis of fibromyalgia and migraine; more than 20% of electroencephalogram (EEG) channels requiring rejection due to artifacts; change in their pharmacological or non-pharmacological treatment regimen during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-55z5hzf	Study of the potentiation of propofol sedation by dipyrone	Not yet recruiting	Intervention	2024-09-18	<NULL>	<NULL>	7353	The role of Dipyrone as an adjuvant in the Sedation of adult patients with Propofol: Randomized, double blind and crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Associação Evangélica Beneficente de Londrina  - AEBEL	Anestesioclinica de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-55z5hzf	<NULL>	Both sexes; 18-60 years old; American Society of Anesthesiologists (ASA)  I and II functional classification	Personal history of allergic or pseudoallergic reactions to dipyrone; propofol and/or lidocaine; pregnant women; regular use of benzodiazepine medications; current history of chemical dependency; children; elderly (&gt;60 years); ASA functional classification &gt; II	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8dyxv8k	Digital care lines in guidance on positive childbirth experience: health education on fear of childbirth through Information and Communication Technologies	Recruitment completed	Intervention	2024-09-18	<NULL>	<NULL>	7354	Digital care lines in guidance on positive childbirth experience: use of Information and Communication Technologies in reproductive health education. Intervention on fear of birth through knowledge of the physiological processes involved in parturition and humanized practices in childbirth care	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-03	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP - HCFMRP	Centro de Referência de Saúde da Mulher de Ribeirão Preto - CRSMRP- Mater	https://ensaiosclinicos.gov.br/rg/RBR-8dyxv8k	<NULL>	Pregnant women with at least one office visit in the pre-natal service of Women&apos;s Health Reference Center of Ribeirão Preto – MATER; informed consent form signed if age at least 18 years old or assent form signed if younger than 18 years old (in this case, with a consent form signed by legal guardian)	Patients that do not have access to a mobile phone with internet connection and access to the free messaging app Whatsapp; clinical conditions that impair the comprehension of the videos (such as alcohol and/or drug addiction, psychiatric diseases without adequate medical treatment)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-4znfspj	Expansion of access to insertion of the copper intrauterine device at the time of delivery using information technology	Recruitment completed	Intervention	2024-09-18	<NULL>	<NULL>	7355	Digital care lines on immediate postpartum contraception counseling: use of information and communication technologies in reproductive health education. Expansion of access to insertion of the copper intrauterine device at the time of delivery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-16	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Centro de Referência de Saúde da Mulher de Ribeirão Preto - CRSMRP- Mater	https://ensaiosclinicos.gov.br/rg/RBR-4znfspj	<NULL>	Pregnant women with at least one office visit in the pre-natal service of Women&apos;s Health Reference Center of Ribeirão Preto – MATER; informed consent form signed if age at least 18 years old or assent form signed if younger than 18 years old (in this case, with a consent form signed by legal guardian)	Patients that do not have access to a mobile phone with internet connection and access to the free messaging app Whatsapp; clinical conditions that impair the comprehension of the videos (such as alcohol and/or drug addiction, psychiatric diseases without adequate medical treatment); patients with medical conditions that are considered to be categories 3 or 4 for the intrauterine device insertion in the immediate postpartum period, according to the World Health Organization; other conditions observed at the moment of childbirth, according to the Women&apos;s Health Reference Center of Ribeirão Preto – MATER protocol, will be considered as exclusion criteria, such as the presence of chorioamnionitis, rupture of membranes for longer than 18 hours, uncontrolled postpartum hemorrhage, multiple vaginal lacerations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8wc3mj5	Effect of the association of Dexamethasone with Ibuprofen on Anesthetic Success, Postoperative Pain and Quality of Life after Root Canal Treatment in patients with Preoperative Pain	Recruiting	Intervention	2024-09-17	<NULL>	<NULL>	7348	Effect of Supraperiosteal Injection of Dexamethasone associated with Ibuprofen on Anesthetic Success, Postoperative Pain and Quality of Life after Endodontic Treatment in patients with Irreversible Pulpitis	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-08-21	Fundação Francisco Mascarenhas/Faculdade Integradas de Patos-FIP	Universidade Federal de Campina Grande	https://ensaiosclinicos.gov.br/rg/RBR-8wc3mj5	<NULL>	Systemically healthy patients of any gender aged between 18 and 65 years; teeth diagnosed with symptomatic or asymptomatic irreversible pulpitis and symptomatic apical periodontitis (presence of preoperative pain); and preoperative pain ranging from mild to severe on the Heft Parker visual analogue scale	Pregnant or breastfeeding women; patients with allergies, sensitivity or adverse reactions to dexamethasone or ibuprofen; individuals who received any analgesic or anti-inflammatory in the last 12 hours before treatment; and non-restorable teeth, with periodontal disease, root resorption, open apex and calcified root canals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-10zh7737	LevantAE! APP: reducing sedentary lifestyle in obese patients before bariatric surgery	Not yet recruiting	Intervention	2024-09-17	<NULL>	<NULL>	7349	Reducing sedentary time in Obese individuals pre-bariatric surgery at a teaching hospital: using the “Levantae! App”	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Centro de Ciências da Saúde	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10zh7737	<NULL>	Men and women; aged 18 years or older up to 59 years old; body mass index ≥ 30kg/m2; not participating in any physical exercise program; being properly monitored at the general surgery outpatient clinic of the Hospital das Clínicas of the Federal University of Pernambuco; being able to understand and use the application; having their own smartphone with a data package capable of installing the application; residing in the metropolitan region of Recife	Have contraindications for practicing physical activities; patients with severe arthritis, fibromyalgia or any other type of disease that prevents them from performing any type of physical activity; do not use the application for at least 70% of the stipulated period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-868rxjt	Effect of bonding on the performance of veneers	Not yet recruiting	Intervention	2024-09-17	<NULL>	<NULL>	7350	Effect of the kind of cement on the performance composite veneer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-868rxjt	<NULL>	An upper or lower anterior tooth (incisor or canine) requiring indirect veneer restoration; presence of antagonists and neighboring teeth making contact, good oral health; age between 18 and 70 years; both genders	Extensive coronary destruction that contraindicates a veneer restoration; teeth with spontaneous or constant pain indicative of irreversible pulpitis; presence of periapical lesions; severe systemic disease; allergy to restorative materials; periodontal disease; bruxism; harmful parafunctional habits; history of hypersensitivity in the teeth to be restored	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-79y4gg2	Effect of Articaine with Sodium Bicarbonate for Local Anesthesia in the Maxilla	Recruitment completed	Intervention	2024-09-17	<NULL>	<NULL>	7351	Comparison between 4% unbuffed Articaine and 1% buffered Articaine solutions in Infiltration in the Maxilla	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2022-10-13	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-79y4gg2	<NULL>	Only healthy participants; both genders; aged between 18 and 40 years will be included; provided they have prior experience with local anesthesia; no history of complications from local anesthesia; and have intact maxillary canines that are responsive to electrical stimulation using a &quot;Pulp Tester&quot;	Pregnant or lactating women; volunteers with systemic conditions that contraindicate anesthesia; those with a history of allergic reactions to any components of the anesthetic solutions used; and those with inflammatory conditions in the region will not be included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-3mchq3q	Feasibility Study of the Concomitant Use of Poly-L-Lactic Acid (PLLA) and Hyaluronic Acid	Recruitment completed	Intervention	2024-09-16	<NULL>	<NULL>	7344	Feasibility analysis of simultaneous application of poly-L-lactic acid (PLLA) and Hyaluronic Acid	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2024-06-01	Univesrsidade Estadual de Montes Claros	Univesrsidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-3mchq3q	<NULL>	Patients diagnosed with facial sagging; age range from 40 to 80 years	History of photosensitivity; keloids; hypertrophic scars and post-inflammatory; hyperpigmentation; pregnancy and lactation; individuals with a local inflammatory skin disorder or active herpes infection at the procedure site; individuals with a history of medical illnesses that contraindicate the procedures; such as intolerance to the components, urticaria to the components; Raynaud&apos;s disease and a history of allergic reactions to the components; patients who do not agree to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-5kcyrnq	Effect of a strength training program for abdominal muscles on performance in multidirectional jumps	Not yet recruiting	Intervention	2024-09-16	<NULL>	<NULL>	7345	Strength training for CORE muscles and performance in multidirectional jumps: implications for training and rehabilitation in sports	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Universidade Federal do Pampa - Campus Uruguaiana	Universidade Federal do Pampa - Campus Uruguaiana	https://ensaiosclinicos.gov.br/rg/RBR-5kcyrnq	<NULL>	Male and female; age between 18 and 35 years; recreational practice in sports involving jumping; who have not had delayed onset muscle pain and ligament or muscle injuries in the lower limb in the last 6 months	Body mass index greater than 30 kg/m²; musculoskeletal and/or vestibular problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8fxzwfh	Comparative study between the use or not of sutures in upper third molar surgeries	Recruiting	Intervention	2024-09-16	<NULL>	<NULL>	7346	Comparative evaluation of the use or not of sutures in upper third molars surgery - a splith mouth randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri – UFVJM	Universidade Federal dos Vales do Jequitinhonha e Mucuri – UFVJM	https://ensaiosclinicos.gov.br/rg/RBR-8fxzwfh	<NULL>	Patients over 18 years of age; both genders; no impairment of general health according to medical history and physical examination; patients with indication for extraction of bilateral maxillary third molars, erupted or partially erupted, asymptomatic	Patients classified as ASA III or ASA IV, according to the American Association of Anesthesiology; use of anti-inflammatories within 15 days prior to surgery; smoking patients; pregnant and breastfeeding women; patients with a history of pericoronitis; patients with cognitive disorders that make it impossible to understand and execute commands; withdrawal of consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-4r4fync	Quality of recovery and postoperative pain in patients undergoing gallbladder removal laparoscopic surgery under low pneumoperitoneum pressure versus standard pressure with moderate or deep neuromuscular block. Randomized controlled study	Data analysis completed	Intervention	2024-09-16	<NULL>	<NULL>	7347	Quality of recovery and postoperative pain in patients undergoing laparoscopic cholecystectomy under low pneumoperitoneum pressure versus standard pressure with moderate or deep neuromuscular block. Randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Medicina de Jundiaí	Hospital Geral do Grajaú	https://ensaiosclinicos.gov.br/rg/RBR-4r4fync	<NULL>	Patients aged between 18 and 65 years; both genders; physical status by the American Society of Anesthesiology I or II;  who will undergo Laparoscopic Cholecystectomy at the Regional Hospital of Jundiaí (Jundiaí-SP) performed on an elective basis	Patient refusal; altered level of consciousness or inability to communicate; presence of contraindication to the use of any agent described in the project; history of alcohol or drug abuse; Body Mass Index greater than or equal to 40; presence of chronic pain or opioid use; presence of neuromuscular disease; history of complicated cholelithiasis such as acute cholecystitis, cholangitis, or pancreatitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8rwbb77	Effect of Laser Light associated with Corticosteroid irrigation in controlling inflammatory manifestations in lower third molar extractions - a randomized clinical trial	Not yet recruiting	Intervention	2024-09-15	<NULL>	<NULL>	7343	Effect of Photobiomodulation associated with Hydrocortisone irrigation for the control of inflammatory manifestations in the extraction of impacted lower third molars – a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-26	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8rwbb77	<NULL>	Eligibility criteria will include participants who: are between 18 and 40 years old, are not pregnant, require bilateral extraction of lower third molars with a similar degree of bone impaction, have no systemic diseases or local conditions that could interfere with the tissue repair process, undergo a surgical procedure lasting up to 60 minutes, have no contraindications to the use of hydrocortisone, have no history of hypersensitivity to mepivacaine, dipyrone, and ibuprofen, have the presence of upper and lower central incisors, and have no light hypersensitivity	Exclusion criteria will include participants under 18 or over 40 years of age, participants who are pregnant, procedures that exceed 60 minutes in duration, trans-surgical complications (e.g., hemorrhage or fainting), participants who do not follow up within the proposed interval or do not return for the second extraction, participants who report using medications other than those provided by the research team, use of anesthetics exceeding the amount outlined in this study (2 cartridges), as well as the absence of upper and lower central incisors, a history of hypersensitivity to mepivacaine, dipyrone, and ibuprofen, and light hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-10d3kfqz	Investigation of sleep problems in children with stuttering	Recruiting	Intervention	2024-09-13	<NULL>	<NULL>	7340	Investigation of Sleep Problems in individuals with Stuttering	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-10d3kfqz	<NULL>	Age between 4 and 11 years; diagnosis of persistent stuttering by a stuttering professional; presenting at least 3% of stuttered syllables or disfluencies typical of stuttering	Neurological alterations; genetic syndromes; mental deficiency; attention deficit hyperactivity disorder; use of medication; and/or other pertinent conditions that could lead to diagnostic errors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-99f794z	The use of Sugarcane biopolymer membrane as a dressing in varicose vein surgery	Recruiting	Intervention	2024-09-13	<NULL>	<NULL>	7341	Efficacy of Sugarcane biopolymer membrane and gel as a dressing in lower limb varicose vein surgery	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2023-02-01	Hospital das Clinicas da Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-99f794z	<NULL>	Patients undergoing varicose vein surgery of the lower limbs at the Hospital das Clínicas of the Federal University of Pernambuco; both sexes; age from 18 to 100 years	Patients who are not in a clinical condition for surgery; patients who do not return on the scheduled reassessment date	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8ry4d4q	Randomized comparative study of the acetabular positioning of hip prostheses performed via the conventional posterior approach and SuperPath technique	Recruiting	Intervention	2024-09-13	<NULL>	<NULL>	7342	Acetabular component positioning in total hip arthroplasty performed by conventional posterior access x supracapsular access assisted by percutaneous portal (SuperPath): a prospective randomized comparative study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8ry4d4q	<NULL>	Patients on the primary hip arthroplasty queue who have hip osteoarthritis waiting for surgery; patient able to read and understand the informed consent form.	Patients under 18 years of age; neurological or orthopedic diseases that alter the gait pattern and may influence functional tests; need for additional procedures in addition to hip prosthesis (shortening osteotomies, need for structured or impacted bone graft and ankylosed hips or those requiring in situ osteotomy).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-743d7pm	Energy expenditure and carbohydrate and fat oxidation in women with polycystic ovary syndrome	Recruitment completed	Observational	2024-09-12	<NULL>	<NULL>	7335	Metabolic profile and energy substrate oxidation in women with polycystic ovary syndrome (PCOS)	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-21	Centro de Saúde Escola - Dr. Joel Domingos Machado da Faculdade de Medicina de Ribeirão Preto da USP	Centro de Saúde Escola - Dr. Joel Domingos Machado da Faculdade de Medicina de Ribeirão Preto da USP	https://ensaiosclinicos.gov.br/rg/RBR-743d7pm	<NULL>	Women, between 18 and 40 years old. Body mass index (BMI) between 25 to 34,9 kg/m². With or without Polycystic Ovary Syndrome (PCOS)	Other hyperandrogenic causes; renal or thyroid diseases; androgen use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-926x38d	Virtual Reality in Individuals with Fibromyalgia and Chronic Pain	Recruiting	Intervention	2024-09-12	<NULL>	<NULL>	7336	Effects of immersive virtual reality-based exercise on pain, kinesiophobia, and catastrophizing in people with fibromyalgia and chronic pain	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Universidad San Sebastián	Universidad San Sebastián	https://ensaiosclinicos.gov.br/rg/RBR-926x38d	<NULL>	Men and women; age 18 years or older; diagnosed with fibromyalgia (American College of Rheumatology 2016 criteria) or chronic pain; not currently participating in another rehabilitation program	Pregnancy or breastfeeding; pain of oncological origin; uncontrolled metabolic disorder; individuals presenting simultaneously with fibromyalgia and other chronic pain from a cause other than fibromyalgia; individuals with any physical or psychological condition that limits communication with the research team or the full application of the intervention protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-65mfym6	Effects of music therapy in patients with mechanical ventilation	Recruitment completed	Intervention	2024-09-12	<NULL>	<NULL>	7337	Effects of music therapy on delirium and ventilatory weaning of patients on mechanical ventilation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Hospital e Maternidade Galileo	Hospital e Maternidade Galileo	https://ensaiosclinicos.gov.br/rg/RBR-65mfym6	<NULL>	Individuals over 18 years old and under 80 years old; of both sexes; patients on mechanical ventilation for more than 48 hours associated with the use of sedative drugs; signing the Free and Informed Consent Form by the responsible family member	Individuals with an underlying disease that may interfere with the interpretation of their level of consciousness, such as previous cerebrovascular accidents; any previously diagnosed dementia; individuals undergoing brain surgery; patients with acute kidney disease; patients with hearing deficit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-104qh4qd	Effect of Abdominal Massage in People with Anxiety and Stress	Data analysis completed	Intervention	2024-09-12	<NULL>	<NULL>	7338	Effect of Visceral Mobilization in patients with Anxiety and Stress Symptoms: a double-blind, randomized, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-16	Colégio Brasileiro de Osteopatia	Universidade de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-104qh4qd	<NULL>	Self-reported symptoms of anxiety and/or stress; age between 18 and 60 years; regardless of sex	Presence of incision or tumor in the abdominal region; presence of fractures, rheumatic pathologies or infection in the acute phase; impossibility of understanding the proposed assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-6fgfrbd	Impact of a muscle strengthening protocol on functionality and dyspnea in patients with Chronic Obstructive Pulmonary Disease during hospitalization in a hospital	Recruiting	Intervention	2024-09-12	<NULL>	<NULL>	7339	Impact of a muscle strengthening protocol on functionality and dyspnea in patients with COPD during hospital stay	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6fgfrbd	<NULL>	Individuals aged at least 60 years of both sexes; patients with Chronic Obstructive Pulmonary Disease; obtain hemodynamically even when using vasoactive drugs, as long as they are in a dose considered safe for mobilization; outside of invasive mechanical ventilation; able to collaborate with the exercises	Individuals with previous neuromuscular diseases; unable to collaborate with the exercises or perform the tests; who present an episode of cardiorespiratory arrest during hospitalization; individuals who do not agree to sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-7y5p3x8	The Benefits of Curcumin Supplementation in Individuals with HIV/AIDS	Recruiting	Intervention	2024-09-12	<NULL>	<NULL>	7362	The effects of Curcumin supplementation in patients with HIV/AIDS	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7y5p3x8	<NULL>	Candidates of both genders. Must be between 36 and 56 years old and be aware of their serological status, regardless of the stage of infection. They are required to have been on continuous antiretroviral therapy for more than six months and be under clinical follow-up at the Specialized Care Service. Candidates should have a normal or investigator-acceptable heart rate during screening. Individuals with the potential to become pregnant must present a negative pregnancy test at the beginning of the study and agree to use an acceptable form of non-hormonal birth control throughout the study period (this includes methods such as double barrier, non-hormonal intrauterine devices, complete abstinence from sexual intercourse that could result in pregnancy, or partner vasectomy performed at least six months before the first dose of the study product). Individuals with the potential to impregnate others must agree to use condoms or other acceptable methods to prevent pregnancy during the study (complete abstinence from sexual intercourse that could result in pregnancy is also acceptable). Participants must have veins suitable for repeated venipuncture and be able to swallow tablets or capsules whole without chewing. They must be willing and able to comply with all aspects of the study protocol, including maintaining the same diet and exercise habits throughout the study period. Candidates must also agree not to donate blood or plasma for 30 days after the study’s completion and be capable of providing voluntary consent	Participants who use protease inhibitors that interact with turmeric, reducing the effectiveness of antiretroviral therapy (ART), will not be eligible for the study. Additionally, those who are breastfeeding, pregnant, or planning to become pregnant during the study period will be excluded. Participants with uncontrolled or controlled blood pressure (≥140 mmHg systolic or ≥90 mmHg diastolic) at screening will also be ineligible. Individuals with a history of heart disease, cardiovascular disease, renal or hepatic failure, or who have been diagnosed with any psychiatric disorder, unstable thyroid disease, or cancer (except localized skin cancer without metastasis or cervical cancer in situ) within the last five years prior to screening will be excluded. Furthermore, any other clinically significant condition or disorder that, in the opinion of the investigator, could pose a risk to the participant or influence the study results will prevent their inclusion. Participants who have undergone major surgery with general anesthesia within three months prior to screening or who have major surgery planned during the study will not be eligible. Similarly, those with a history of blood clotting disorders will not be allowed to participate.Individuals who have reported significant blood loss or blood donation totaling between 101 mL and 449 mL within 30 days prior to the first pharmacokinetic visit, or a blood donation of more than 450 mL within 56 days before the first pharmacokinetic visit, will also be excluded. In addition, people with gastrointestinal abnormalities or obstructions that impair swallowing (e.g., dysphagia) and digestion (e.g., known intestinal malabsorption, celiac disease, inflammatory bowel disease, chronic pancreatitis, steatorrhea) will not be eligible for the study. Participants with gallstones, bile duct obstruction, stomach ulcers, excess stomach acid, or gastroesophageal reflux disease will also be excluded. Those with a history of alcohol or substance abuse within 12 months prior to screening, or whose use, in the opinion of the investigator, may compromise their participation in the study, will not be accepted. Finally, individuals with any other active or unstable medical conditions, or who are using medications, supplements, or therapies that could adversely affect the conduct or outcomes of the study, or pose a significant risk to their health, will not be included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-22k3fm7	Effects of Stimulation of the Auricular Branch of the Vagus Nerve on Cardiovascular parameters in people recovered from Covid-19	Recruitment completed	Intervention	2024-09-11	<NULL>	<NULL>	7330	Effects of Stimulation of the Auricular Branch of the Vagus Nerve on Cardiovascular parameters in people recovered from Covid-19	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-22k3fm7	<NULL>	Adult males and females; age between 18 and 60 years; recovered from Covid-19, with supporting documentation, a minimum of four weeks and a maximum of one year and who remain with at least one of the characteristics of the subacute or chronic phase of the disease; having received assistance in the health network of Santa Catarina; being able to walk independently; understand Brazilian Portuguese well enough to complete questionnaires and tests	Individuals with pre-existing cardiovascular diseases; smokers; suspected or confirmed pregnancy; cognitive alterations, injuries to the pinna or its absence; without supporting documentation for a positive Covid-19 test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8yp7h7k	Immunonutrition and mental factors in recovery after Stomach Cancer surgery	Not yet recruiting	Observational	2024-09-11	<NULL>	<NULL>	7331	Immunonutrition and psychosocial factors in the recovery of patients after Gastric Cancer surgery: a multidimensional analysis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8yp7h7k	<NULL>	Adult or elderly patients; age 18 or older; both genders; undergoing gastric cancer surgery who used immunonutrition	Patients with pre-existing hematologic diseases that might affect blood count results; patients with other malignancies, and those with a history of psychological disorders that impair their ability to respond to the study questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-9g53rs5	Follow-up study of patients with Kidney Disease: survival, fisical capacity, nutritional, mental and risk factors.	Recruiting	Observational	2024-09-11	<NULL>	<NULL>	7332	Cohort study of patients with Chronic Kidney Disease: survival, functional, nutritional, cognitive capacity and risk factors.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-01	Universidade Federal de Pelotas	Hospital Universitário São Francisco de Paula (HUSFP)	https://ensaiosclinicos.gov.br/rg/RBR-9g53rs5	<NULL>	Individuals diagnosed with chronic kidney disease; of both genders; undergoing treatment at the service for more than 3 months; aged 18 or over	Individuals undergoing treatment at the service for less than 3 months; Individuals under 18	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8dtfcnp	Evaluation of the Healing effect of Jucá in the mouth	Recruitment completed	Intervention	2024-09-11	<NULL>	<NULL>	7333	Evaluation of the Healing activity of Jucá in oral mucosa	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8dtfcnp	<NULL>	Patients referred for biopsy of the minor salivary glands at the Faculty of Dentistry of the Federal University of Amazonas; of both sexes; age between 18 and 80 years; with healthy oral mucosa and no soft tissue injuries	Patients with a clinical history of Diabetes and/or scarring disorders; pregnant women; breastfeeding women; elderly people over 80 years of age; patients who continually use mouthwash and/or who use tobacco and alcohol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-10n92zfs	Understanding changes in the body and metabolism of patients undergoing treatment for Acute Leukemia	Recruiting	Observational	2024-09-11	<NULL>	<NULL>	7334	Characterization of body composition and changes in metabolism in patients undergoing treatment for Acute Leukemia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-02	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10n92zfs	<NULL>	Participants over 18 years old; both sexes; diagnosed with acute leukemia; treated at the leukemia outpatient clinic of the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto (HCFMRP-USP), who will begin high-intensity protocols, designated by the medical team	Patients with cognitive difficulties that make it impossible to understand the study and consent; patients with other associated neoplasms; evidence of infection with human immunodeficiency viruses, hepatitis B or C; women with confirmed pregnancy; evidence or suspicion that the participant will not comply with the requirements of the study protocol; proof or suspicion that the participant is unwilling or unable to understand the information provided in the procedure for obtaining the free and informed consent form; any other factor that, in the opinion of the investigator, may compromise the participant&apos;s ability to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-10prm4vn	Functional capacity and mental health	Recruiting	Intervention	2024-09-10	<NULL>	<NULL>	7323	Functional capacity and mental health: effect of combined strength and aerobic training for middle-aged and elderly adults undergoing treatment for substance use disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-09	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-10prm4vn	<NULL>	To join the sample, participants must meet the following inclusion criteria: Men and women; Age equal to or over 50 years old; Be monitored for the use of alcohol and/or other drugs at the HCPA Addiction Outpatient Clinic; Be clinically fit to perform physical exercise and therefore present a medical certificate stating fitness to practice; Not engaged in a physical exercise program (with more than 2 weekly sessions of light to moderate physical activity for a minimum of 30 minutes); Be able to communicate; Be able to provide consent to participate in the research. The research team has a clinical cardiologist who evaluate and issue a certificate for participants to participate in the research	Participants who meet the following criteria will be excluded: Individuals who present psychotic symptoms and/or cognitive deficits that make it difficult to apply mental health and functional capacity tests; Individuals who have acute or chronic injuries and clinical health problems that prevent the practice of physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-938v5jd	Physiotherapeutic exercise program for pain, physical function and quality of life in people with chikungunya	Recruitment completed	Intervention	2024-09-10	<NULL>	<NULL>	7324	Effect of a Rehabilitation Programme on functionality in people with Chikungunya sequelae	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-04	Faculdade de Ciências da Saúde do Trairí da Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairí da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-938v5jd	<NULL>	Clinical diagnosis of chikungunya with symptoms for more than three months; have sufficient cognitive level to understand the proposed activities; both sexes (female and male); between 18 and 75 years of age; residents of the state of Rio Grande do Norte	Individuals who have contraindications to exercise; people who are participating in another exercise program or in another type of treatment at the same time; those who for some reason are unable to continue with the proposed intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-8r96g87	Importance of oral health guidance for pregnant women	Not yet recruiting	Intervention	2024-09-10	<NULL>	<NULL>	7325	Evaluation of prenatal dental care efficacy on oral health literacy of pregnant women: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8r96g87	<NULL>	Pregnant; second trimester of pregnancy; own a smartphone	High-risk pregnancy; third trimester of pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-78934cv	Potential of Resveratrol as an auxiliary treatment for type 2 Diabetes Mellitus	Not yet recruiting	Intervention	2024-09-10	<NULL>	<NULL>	7326	Effect of Resveratrol on the metabolic profile of individuals with type 2 Diabetes Dellitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-78934cv	<NULL>	The following inclusion criteria will be used to recruit individuals: (1) diagnosed with type 2 diabetes mellitus; (2) aged between 18 and 59 years; (3) undergoing oral hypoglycemic treatment or combination therapy for at least 6 months; (4) not undergoing any antioxidant therapy such as vitamin supplements; and (5) not being allergic to the components present in the treatments	Patients with type 1 diabetes, pregnant women, lactating women and patients with severe heart disease, liver disease and renal failure will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-89d82xv	Analysis of the morphology of the skull bones in patients treated with fixed appliances	Recruiting	Intervention	2024-09-10	<NULL>	<NULL>	7327	Morphological and functional analysis of patients with mandibular lateral deviations treated orthodontically with the GEAW technique	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-05	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-89d82xv	<NULL>	Need for orthodontic treatment; resence of mandibular lateral deviation; acceptance of treatment with fixed orthodontic appliances; aged between 18 and 30 years; both sexes	Missing teeth; unsatisfactory prosthetic rehabilitations; symptoms of moderate and severe temporomandibular disorder (TMD)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:59
RBR-7rz7b2s	Effect of assisted standing on strength and muscle mass in patients with ICU-acquired weakness	Recruiting	Intervention	2024-09-10	<NULL>	<NULL>	7328	Effect of passive orthotatism on muscle strength and mass of patients with weakness acquired in the ICU	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7rz7b2s	<NULL>	Patients of both sexes will be included; aged 18 years or over; clinical and surgical patients admitted to the HC/UNICAMP Adult ICU; without sedatives; patients with ICU-acquired muscle weakness with MRC less than or equal to 48; collaborative patients; with a Glasgow Coma Scale score greater than or equal to 8, with a motor response score equal to 6, for application of the MRC scale and surface electromyography; hemodynamic stability with mean arterial pressure greater than 65 mmHg with minimal or no use of vasoactive drugs; peripheral oxygen saturation greater than or equal to 90% with FiO2 less than or equal to 60% and PEEP less than or equal to 10cmH2O; patients and/or legal representatives who agree to participate in this study and sign the Informed Consent Form	Hemodynamic instability; recent acute myocardial infarction or cardiac arrhythmias proven by electrocardiogram; use of sedatives; use of high parameters in MV; fractures of lower limbs or upper limbs; use of external fixator; amputation of lower limbs or upper limbs; orthopedic alterations that limit orthostatism; significant calcaneal eschar; patients with deep vein thrombosis; patients with significant thrombocytopenia with values below 50. 000; hemiplegic patients; patients after spinal cord trauma; patients with neuromuscular diseases; patients with intracranial pressure monitoring and/or external ventricular shunt; patients with intra-aortic balloon; patients with fever greater than or equal to 37.8°C	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-9n4t4yt	Contributions of Auriculotherapy in the symptoms of anxiety and depression in health professionals	Recruitment completed	Intervention	2024-09-10	<NULL>	<NULL>	7329	The use of Integrative and Complementary Practices - PICs -  in the city of Londrina - UEL/ Londrina Cuty Hall	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-9n4t4yt	<NULL>	Health workers over 18 years of age; both sexes; who agreed to participate in the research; who received three auriculotherapy sessions	Health workers who did not agree to participate in the research;  or who accepted but did not receive three auriculotherapy sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-28swytb	Use of Dexmedetomidine as an auxiliary medication in nerve blocks to control pain in hip surgery: randomized clinical study	Not yet recruiting	Intervention	2024-09-09	<NULL>	<NULL>	7322	Use of Dexmedetomidine as an adjuvant in Peng Block for hip surgery: randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Instituto de Assistência Médica ao Servidor Público Estadual	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-28swytb	<NULL>	Patients indicated for hip surgery under spinal anesthesia; of both sexes; aged between 18 and 85 years; ASA classification (American Society of Anesthesiology) I, II and III	Patient refusal; known sensitivity or contraindication to local anesthetics or dexmedetomidine; history of psychological disorders; localized infection at the blockage site; use of anticoagulants/coagulopathies (platelet count &lt; 80,000 or  international normalized ratio (INR) &gt; 1.5)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-2rsmbsf	The effects of a Zumba Dance and Mat Pilates in women post Breast Cancer Surgery	Not yet recruiting	Intervention	2024-09-06	<NULL>	<NULL>	7320	The effects of a Zumba Dance and Mat Pilates protocol in women post Breast Cancer Surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2rsmbsf	<NULL>	Age over 18 years; females; who have undergone surgery to remove the tumor; undergoing chemotherapy and/or radiotherapy and/or hormonal treatment and/or immunotherapy; who have completed chemotherapy and/or radiotherapy and/or hormonal treatment and/or immunotherapy within a maximum period of 5 years; sedentary and non-sedentary; normal body mass index, overweight, or obesity class I; availability of time to undergo the offered protocols; capacity for understanding	Refusal to receive the protocol; pregnant women; amputation of one or more upper and/or lower limbs; neurological disorders with cognitive impairments or movement difficulties; decompensated heart diseases; severe metastases limiting functional status; and failure to respond to three contact attempts by the researcher for scheduling	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-9j49xsg	Effect of anesthesia on abdominal wall during video surgery in patients undergoing intestinal resection: a double-blind, randomized clinical study	Data analysis completed	Intervention	2024-09-06	<NULL>	<NULL>	7321	Analgesic effect of laparoscopic-guided transversus abdominis plane block (TAP block) in laparoscopic colorectal surgery: a randomized, double-blinded trial	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2021-08-09	Hospital Governador Israel Pinheiro	Hospital Felício Rocho	https://ensaiosclinicos.gov.br/rg/RBR-9j49xsg	<NULL>	Volunteers with an indication for segmental colon resection; aged 18 years or older; elective surgical proposal; laparoscopic surgery proposal; both sexes	Volunteers with pre-anesthetic assessment ASA IV-V; a history of allergic reactions to local anesthetics; complaints of chronic pain, chronic opioid use, or opioid tolerance; the need for resection of organs other than the colon, rectum, and/or cecal appendix; preoperative signs of intestinal obstruction; surgical indication for laparotomy access; signs of inflammation or infection at the TAP block puncture sites; surgeries for the treatment of neoplastic recurrence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-2mv477g	Literacy task force: improving reading abilities impaired by the COVID-19 pandemic among elementary school children in the city of Londrina-PR	Terminated	Intervention	2024-09-05	<NULL>	<NULL>	7319	Creation of a program to accelerate reading learning for children among elementary school children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-20	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-2mv477g	<NULL>	Children (male and female) attending the 2nd and 5th grade of elementary school of the selected schools, with typical development, who are 7 years old or more; children whose teachers agree to participate in the training of the intervention program; teachers who agree to give part of their classes to the intervention	Children without the Informed Consent Form (ICF) delivered; children in school inclusion situation (Autism Spectrum Disorder (ASD) of Moderate and Severe level and Intellectual Disability confirmed by report); children who do not provide verbal consent in the pre-test; teachers who do not sign the IFC	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-65tyfff	Prevention program of Lip, Oral Cavity, and Oropharyngeal Cancer: intervention and costs of the program	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7309	Prevention Program of Oral Cavity, Lip and Oropharyngeal Cancer: intervention process and cost-effectiveness	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal de Goiás	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-65tyfff	<NULL>	Dentists, phisians, nurses, nursing technicians, dental assistants, and community health agents working in primary health care units and secondary care professionals, selected according to planning with the SMS-Goiania team. Risk group for individuals aged 40 years or older, smokers, those exposed to the sun for more than 2 hours daily, and those with a history of sexually transmitted diseases	Individuals who do not agree to participate in the research and those under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-7g99bx3	Manual therapy to relieve postpartum shoulder pain	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7310	The effect of manual therapy to relieve pain in the shoulder girdle in the immediate postpartum period: series of 10 cases	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-28	Universidade Santa Cecília	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-7g99bx3	<NULL>	Lactating women in the immediate postpartum period, between the second and third day postpartum; admitted to the Guilherme Álvaro Hospital; arising from a high-risk pregnancy; primiparous; from 18 years of age; presence of pain in the region of the shoulder girdle and/or breasts, without the presence of breast complications (breast engorgement, breast fissure, mastitis, blockage of the ducts and breast abscess); postpartum women who have signed the Free and Informed Consent Form	Presence of impairment of the shoulder girdle in the previous period and/or during pregnancy, such as: muscle and/or joint injury, dislocation or subluxation, tendinopathy(ies), infection and local surgery(ies); breastfeeding woman with a history of benign breast disease, breast cancer, Paget&apos;s disease and breast cyst; previous breast surgery (breast reconstruction and silicone prosthesis); cognitive deficit; use of medications that depress the central nervous system; desire to give up studying	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-23t5jbh	Modification of Frailty status in older adults: effect of Bodyweight Interval Exercise	Data analysis completed	Intervention	2024-09-04	<NULL>	<NULL>	7311	Modification of Frailty status in older adults: efficacy of Bodyweight Interval Training	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-03	Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23t5jbh	<NULL>	Older people aged sixty years or older; scoring on one or more components of the self-reported frailty screening tool; preserved mobility; availability to engage in training three times a week; signing the informed consent form	Present a medical diagnosis of dementia; psychiatric disorders; mental disability; medical diagnosis of stroke with severe impairment; physical impairment that prevents mobility; unavailability to attend training sessions three times a week; not scoring on at least one component of the self-reported frailty screening tool	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:13
RBR-42qj6vx	Effect of Meditation on women with Insomnia	Recruitment completed	Intervention	2024-09-04	<NULL>	<NULL>	7312	Effect of an Online Meditation Program on women with Insomnia	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-28	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-42qj6vx	<NULL>	Women with insomnia; aged 18 to 47	Women who are already in the menopausal transition, that is, with an irregular menstrual cycle; women who declare that they have practiced some form of meditation and/or cognitive behavioral therapy for insomnia (CBT-I) in the last 2 months; women who have used medication for sleep and/or anxiety in the last month, such as: benzodiazepines, antihistamines, hypnotics, hypnotic herbal medicines, sedatives, antidepressants, antipsychotics, stimulants (amphetamine and modafinil) and corticosteroids; shift workers and illiterate participants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-10z352nk	Study to analyze the clinical behavior of extra short implants and conventional length implants for the treatment of the posterior region of the jaw with missing teeth	Recruitment completed	Intervention	2024-09-04	<NULL>	<NULL>	7313	Analysis of Extra-short and Conventional Implants installed in the posterior region of the mandible: Clinical study, controlled, randomized, split-mouth design	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-15	Instituto Latino Americano de Pesquisa e Ensino Odontológico	JJGC Industria e Comércio de Materiais Dentários S.A.	https://ensaiosclinicos.gov.br/rg/RBR-10z352nk	<NULL>	To participate in this study, patients must present the following characteristics: Similar degree of atrophy in the bilateral posterior region of mandible, with a minimum residual bone height of 10 mm and width of 6.0 mm, distance from the bone crest to the superior cortex of the canal mandibular (evaluated by Cone Beam computed tomography); Additionally, for eligibility, patients must be 18 years of age, must sign a consent form prior to beginning the study and be committed to participating throughout the study period follow-up	To participate in this study, patients must not present the following characteristics: general contraindications to surgeries with dental implants; patient undergoing irradiation in the head and neck region; patients with immunosuppression and immunosuppression; treated or in treatment with anti-resorptive medications or those that alter bone metabolism; untreated periodontitis; poor oral hygiene and low motivation; pregnancy or breastfeeding; uncontrolled diabetes; psychiatric problems or unrealistic expectations; absence of dentition opposite the area intended for receive the implants; extraction sites (less than 3 months post-extraction); smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-787ykrm	Body responses to Exercises of three different Intensities, acute and chronic	Data analysis completed	Intervention	2024-09-04	<NULL>	<NULL>	7314	Physiological, Biochemical, and Immunological responses to High, Moderate, and Low Intensity Exercises acutely and chronically	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade do Extremo Sul Catarinense	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-787ykrm	<NULL>	Present the signed Informed Consent Form (TCLE); be available to perform exercises three times a week; suit the age for each group between 20 and 40 years old; present a medical certificate authorizing participation; masculine gender	Give up before the intervention is due to complete; have a problem (physical) that makes it impossible to continue activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-3jxmntz	Educational proposal for the Birthing workshop methodology for health professionals	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7315	Psychoeducational Proposal of the Birthing workshop methodology for primary care professionals	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-12	Universidade Santa Cecília - UNISANTA	Secretaria Municipal de Saúde de Santos	https://ensaiosclinicos.gov.br/rg/RBR-3jxmntz	<NULL>	For primary health care professionals - work directly in prenatal care for pregnant women; work in the health units proposed in the study; be 18 and over; agreement to participate in the research and signature of the Free and Informed Consent Form (ICF) - health professionals For postpartum women - having received prenatal care at the health units participating in the present study; nulliparous; be 18 and over; agreement to participate in the research and signature of the TCLE for postpartum women	Withdrawal from participating in the study at any time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-93gmjsz	The use of Laser Therapy (ILIB) in pain and improvement of quality of life of patients with Rheumatoid Arthritis	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7316	Analysis of the effectiveness of Laser Therapy (ILIB) for pain, kinesiophobia, handgrip strength and impact on the quality of life of patients with Rheumatoid Arthritis: planned and controlled clinical trial	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2024-09-15	Faculdade de Enfermagem e Medicina Nova Esperança	Faculdade de Enfermagem e Medicina Nova Esperança	https://ensaiosclinicos.gov.br/rg/RBR-93gmjsz	<NULL>	People with rheumatoid arthritis; aged between 35 and 75 years; both genders; with joint signs and symptoms lasting at least three months; able to fill out the Informed Consent Form	People with juvenile idiopathic arthritis; pregnancy; collagenous tissue diseases; chronic infectious disease; severe acute or chronic underlying disease; with changes in clotting factors; with hemorrhages; glaucoma; pregnant women; with a malignant tumor or cancer and missing more than 25% of irradiation treatment sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-62w99vg	Relationship between motor distraction and Transcranial Direct Current Stimulation in handgrip	Not yet recruiting	Intervention	2024-09-04	<NULL>	<NULL>	7317	Influence of isometric contraction of the index finger on contralateral palmar grip strength (overflow) in patients after Stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-11-04	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-62w99vg	<NULL>	Healthy adults; with a diagnosis of ischemic stroke confirmed by computed tomography or magnetic resonance imaging, between 3 weeks and 1 year after the stroke; of both sexes; aged between 18 and 59 years old	Individuals with any metal in the cranial cavity; injuries in the electrode placement area; with joint deformity in the upper and lower limbs; previous skull, eye or decompression surgery; severe cognitive impairment on the mini mental state examination scale (MMSE); uncontrolled epileptic seizure; in addition to clinical instability; global aphasia; previous visual disturbances; amputation of limbs; other associated neurological diseases or pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-24yqvc7	Blood alteration among pesticide applicators in the Western Paraná	Recruiting	Observational	2024-09-04	<NULL>	<NULL>	7318	Monoclonal Gammopathy of Undetermined Significance (MGUS) among pesticide applicators in the  Western Paraná	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-21	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-24yqvc7	<NULL>	Case group: volunteers; male; over 50 years old; current pesticide applicators or who have worked as pesticide applicators in the past. Control group: volunteers; male; over 50 years old; no history of exposure to pesticides	People under 50 years of age; regardless of whether or not they are exposed to pesticides	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-6y5t5st	Use of an magnifying glass to detect plaque, wear and decay around orthodontic brackets	Terminated	Observational	2024-09-03	<NULL>	<NULL>	7304	Use of a new ultraviolet light-emitting device (reveal) to evaluate the presence of biofilm, demineralization and incipient caries around orthodontic brackets	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-21	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-6y5t5st	<NULL>	Patients aged 18 years or over; good general health; for the experimental group, patients with a minimum treatment time with a fixed orthodontic appliance of 1 year, counting from the bracket bonding appointment; and presence of orthodontic brackets on upper anterior teeth	Patients with significant disabilities that affect manual dexterity or oral hygiene practice; who has taken antibiotics in the last 2 months; who refused to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-5pb2g33	Non-Invasive Head Electrical Stimulation Combined With Physical Exercise for Individuals With Knee Pain for More than Three Months	Not yet recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7305	Analysis of the application of Transcranial Direct Current Stimulation combined with an Exercise protocol on Pain and Physical Function outcomes in individuals with Knee Osteoarthritis: A randomized, controlled, blinded clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-05	Faculdade de Ciências da Saúde do Trairí da Universidade Federal do Rio Grande do Norte	Faculdade de Ciências da Saúde do Trairí da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5pb2g33	<NULL>	Female individuals; Score pain at least three on the numerical pain scale; Not undergoing physiotherapy treatment for at least sixty days	History of epilepsy; Metal devices implanted in the skull; Significant psychiatric or neurological illnesses that prevent the patient from responding to the study assessment instruments; Being pregnant; Having undergone some type of infiltration in the knee joint in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-8f8dsqg	Evaluation of a universal adhesive containing naringin in non-carious cervical lesion restorations: a clinical trial.	Not yet recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7306	Evaluation of the clinical longevity of a universal adhesive system containing nanoencapsulated naringin in self-etch mode in non-carious cervical lesion restorations: a double-blind randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-15	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8f8dsqg	<NULL>	Participants with good general health; participants aged over 18 years to 70 years; men and women; acceptable level of oral hygiene; participants must present at least 20 teeth in occlusion; 20 teeth in function; no active clasps from removable partial dentures on the included teeth; the teeth should not be abutments for prostheses; absence of periodontal disease; no active carious lesions; no parafunctional habits; participants should have at least two non-carious cervical lesions to be restored in different teeth; the lesions should be non-retentive; lesions deeper than 1 mm; lesions that involve both enamel and dentin of vital teeth; and the cavosurface margin should not involve more than 50% of the enamel	Participants with extremely poor oral hygiene; participants using orthodontic devices; participants with severe or chronic periodontitis; participants with parafunctional habits; participants with known allergies to resin-based materials or any other materials used in this study; pregnant women; breastfeeding women; participants on chronic use of anti-inflammatories, analgesics, and psychotropics; participants who have difficulty attending follow-up appointments after the restoration will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-10rvpcp3	Immediate Effect of Osteopathic Manipulative Treatment on ankle movement and gait in Individuals with dorsiflexion limitation	Not yet recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7307	Acute effect of Osteopathic Manipulative Treatment on ankle range of motion and spatio-temporal and kinematic gait variables in individuals with limited dorsiflexion: pragmatic crossover randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10rvpcp3	<NULL>	Non-pregnant adult subjects; aged between 18 and 40 years; with ankle dorsiflexion limitation measured by the Weight Bearing Lunge Test (Lunge Test); who have never undergone manipulative treatment or manual therapies; without ankle and/or foot surgery, ankle sprains in the last 6 months; without a diagnosis of neurological disease; who agree to participate in the study by signing the informed consent form	Participants who present with acute musculoskeletal and osteoarticular conditions in the lower limbs on the day of the assessment and intervention will be excluded, with acute musculoskeletal and osteoarticular conditions in the lower limbs defined as those for which participants are using analgesics and anti-inflammatory medications to control pain and the inflammatory process; conditions that interfere with gait or standing position	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-10qzbjms	Effect of intervention with exercise, nutritional guidance, and therapy in severe obesity	Recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7308	Effects of physical exercise associated with a nutritional and psychological intervention on malignant obesity: relationship between cardiovascular risk and oxidative stress	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Escola Superior de Educação Física da Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10qzbjms	<NULL>	Volunteers eligible for bariatric surgery; both sexes; non-smokers; between 18 and 59 years old; body mass index greater than or equal to 35 kg/m² in the population with comorbidities; and body mass index greater than or equal to 40 kg/m² in the population without comorbidities	Super obese volunteers (body mass index greater than 50kg/m²); diagnosed with cardiac pathologies; who cannot exercise due to musculoskeletal health conditions; does not have internet access to follow interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-8qcgzxw	Comparison between infiltration with Hyaluronic Acid and Corticosteroid in the joint in the treatment of chronic low back pain: clinical study	Not yet recruiting	Intervention	2024-09-03	<NULL>	<NULL>	7677	Comparative study between Hyaluronic Acid and Corticosteroids in facet joints in the treatment of chronic low back pain: randomized clinical study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2025-05-01	Hospital e Maternidade São Domingos	Hospital e Maternidade São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-8qcgzxw	<NULL>	Both genders; older than 18 years; with chronic low back pain for more than 3 months; with pain intensity greater than 4 on the visual analogue pain scale; no radicular pain; caused by degeneration of the facet joint and which presents relief after test block	Trauma patients; neurological deficits; infection at the puncture site; cognitive impairment; psychiatric illness; hypersensitivity to medications; use of anticoagulants; coagulopathy and pregnant women will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-49w7xgy	Effect of Bixa orellana L. phytocomplex (Chronic®) supplementation in patients with fibromyalgia: a randomized, double-blind, placebo-controlled pilot study	Recruiting	Intervention	2024-09-02	<NULL>	<NULL>	7301	Efficacy and safety of Bixa orellana L. phytocomplex (Chronic®) supplementation in patients with fibromyalgia: a randomized, double-blind, placebo-controlled pilot study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-07-05	Hospital das Clinicas da Faculdade de Medicina da USP	Hospital das Clinicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-49w7xgy	<NULL>	Thirty women diagnosed with fibromyalgia, aged 18 to 60 years, who meet the American College of Rheumatology criteria for the diagnosis of fibromyalgia will be recruited. Participants will be selected from the fibromyalgia outpatient clinic at the Rheumatology Service of the Hospital das Clínicas, School of Medicine, University of Sao Paulo, a high-complexity, tertiary service of the Unified Health System.	Women with the following conditions will be excluded from the study: associated inflammatory rheumatic diseases; advanced chronic kidney disease (stages IV or V); diseases affecting locomotion and mobility, such as knee or hip osteoarthritis; severe psychiatric disorders that hinder proper understanding of the study and follow-up; pregnancy, use of oral anticoagulants (due to the risk of drug interactions); active neoplasia; and refusal to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-107wnpmy	Resting energy expenditure and use of energy substrates in healthy and obese individuals	Recruiting	Observational	2024-09-02	<NULL>	<NULL>	7302	Resting metabolic rate and substrate oxidation in healthy and obese individuals	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-11	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-107wnpmy	<NULL>	Both biological sexes; age 18 or over; have taken an indirect calorimetry test between 2017 and May 2024	Critical chronic illness; hospitalization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-9gmbt9v	Exercise and high-altitude exposure as therapy for individuals with type 2 Diabetes Mellitus	Recruiting	Intervention	2024-08-30	<NULL>	<NULL>	7300	Effects of training breathing reduced oxygen air during exercise pauses on hematologic responses, energy metabolism, and physical fitness in individuals with type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-15	Escola de Educação Física e Esportes de Ribeirão Preto da Universidade de São Paulo	Escola de Educação Física e Esportes de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9gmbt9v	<NULL>	men and women;18 to 59 years old;type 2 diabetes mellitus diagnosis (fasting glucose &gt;126 mg/dL, or &gt;200 mg/dL at any time, or glycated hemoglobin &gt;6.5%) without complications;absence of insulin therapy;presentation of a completed and signed Physical Activity Readiness Questionnaire (PAR-Q);stable weight (changes &lt;3 kg) for at least three months before the study	exposure to altitudes of &gt;1500m in the last three months or during the study;use of insulin therapy during the study;unstable angina;uncontrolled hypertension;lung problems;severe valvular disease;decompensated heart failure;renal failure;neurological and orthopedic problems that prevent physical exercise;surgery scheduled during the study period;less than 87.5% of sessions completed (limit of 3 absences)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-10kn9x8f	Effect of the association of Amitriptyline or Jambu with lidocaine and Prilocaine	Not yet recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7294	Evaluation of the association of Amitriptyline or Acmella Oleracea with Lidocaine and Prilocaine nanocapsules in topical anesthesia: randomized, crossover clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2024-10-05	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10kn9x8f	<NULL>	Age 18 or older and under 30 years old. Both genders. Undergraduate and graduate students of the Piracicaba School of Dentistry. Having accepted and signed the Free and Informed Consent Form - Healthy individuals; those who do not present any type of comorbidity that could generate any risk to the volunteer during the study and do not use continuous medications. Previous experience with local anesthesia, previously with an anesthetic agent of the same class (amide), thus, we can state that they have already had topical use of a similar drug without negative responses. Absence of history of allergy or complications resulting from local anesthetic. Who does not use medications that alter the perception of pain. Upper premolars (14 and 24) healthy on both sides (absence of restorations). Responsive to the Pulp Tester electrical stimulus, an electrical impulse emitting device, called Pulp Tester (PTE) will be used	Pregnant women. Breastfeeding women. Under 18 years of age and 30 years of age or older. Refusal to adhere to treatment using topical drugs. Reporting allergies to any component of the formula. Taking antidepressants, anticonvulsants and anti-inflammatories. Presence of inflammation in the region. Being under direct supervision of researchers (developing some type of activity in undergraduate or graduate studies)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-7wqksdc	Development and evaluation of the efficacy of a cosmetic emulsion for skin with Dermatoporosis in people with and without Diabetes	Recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7295	Development and evaluation of the clinical efficacy of a topical formulation for skin with Dermatoporosis in healthy and Diabetic patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-30	Faculdade de Ciências Farmacêuticas da Universidade Estadual de Campinas	Kosmoscience Ciência e Tecnologia Cosmética Importação e Exportação Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7wqksdc	<NULL>	First and second stages of the study - 18 to 60 years old; female; phototype I to VI; normal to dry body skin; intact skin in the study area; agree to comply with the procedures and requirements of the study; sign the Free and Informed Consent Form. Third stage of the study - 60 to 90 years old; both genders; phototype I to VI; agree to comply with the procedures and requirements of the study; sign the Informed Consent Form. Fourth stage of the study - 60 to 90 years old; both genders; phototype I to V; 50% of the panel (25 participants with type I or II diabetes mellitus) and 50% of the healthy panel; agree to comply with the procedures and requirements of the study; agree not to undergo dermatological and/or aesthetic body treatments until the end of the study; sign the Free and Informed Consent Form	History of allergic reactions, irritation or intense sensations of discomfort to topical products: cosmetics or medicines. Skin markings in the experimental area that interfere with the assessment of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, large freckles and warts, sunburn). Patients unable to return for a clinical evaluation. Presence of active dermatoses (local or disseminated) that could interfere with the results of the study. Use of non-hormonal anti-inflammatory drugs, corticosteroids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study. Intense sun exposure or tanning sessions up to 15 days before the initial assessment. Aesthetic or dermatological body treatment up to 4 weeks before the study. Hormonal treatments that have not been stable in the last 3 months. People directly involved in carrying out this study and their families. Participating in another study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-6bczsb6	How Electromassage can help patients with Hematological Cancers: a study on sensory aspects and well-being	Not yet recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7297	Effects of Electromassage on Perceptual Aspects of Hematooncology patients: a non-randomized clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-15	Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6bczsb6	<NULL>	Individuals of both male and female ages between 18 and 59 years old; diagnosis of hematological cancer; being treated for hematological cancer; and, medical clearance to participate in the research	Patients with the presence of metastasis; exacerbated diseases (e.g. severe cardiovascular or respiratory diseases); contraindication for the use of electromassage: loss of sensitivity, acute skin injuries and/or devitalized skin; and poor general health that makes it impossible to carry out all assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-10gd8362	A study of the IndigoTM aspiration system seeking to evaluate the long-term safety of treating Pulmonary Embolism	Recruiting	Observational	2024-08-29	<NULL>	<NULL>	7298	A prospective, multicenter study of the IndigoTM aspiration system seeking to evaluate the long-term safety and outcomes of treating Pulmonary Embolism	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-25	Centro Universitário do Distrito Federal	Hospital Santa Lucia Sul	https://ensaiosclinicos.gov.br/rg/RBR-10gd8362	<NULL>	Clinical signs and symptoms consistent with acute Pulmonary Embolism with duration of 14 days or less. Right Ventricle and Left Ventricle ratio greater than or equal 0.9 assessed by diagnostic computed tomographic angiography (CTA) or echocardiogram. Frontline endovascular treatment with the Indigo Aspiration System per Instructions For Use. Patient, man or woman, is greater than or equal 18 years of age. Informed consent obtained per Institutional Review Board/Ethics Committee requirements	Contraindication to systemic or therapeutic doses of anticoagulants (e.g. heparin). Stage III or IV cancer or cancer which requires active chemotherapy during the course of the study. Known serious, uncontrolled sensitivity to radiographic agents. Life expectancy less than 180 days. Patients on extracorporeal membrane oxygenation. Pregnant patients. Current participation in another investigational drug or device study that may confound the results of this study. Studies requiring extended follow-up for products that were investigational but have since become commercially available are not considered investigational studies. Other medical, social, or psychological conditions that, in the opinion of the Investigator, precludes the patient from appropriate consent, could limit the patient&apos;s ability to participate in the study, including compliance with follow-up requirements, or that could impact the scientific integrity of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-88c4zpy	Assessment of skin acceptability with perceived efficacy for both adults and children	Not yet recruiting	Intervention	2024-08-29	<NULL>	<NULL>	7299	ORC_110114_EN24-0215-01_Dermal acceptability assessment with perceived efficacy and Dermal and pediatric acceptability assessment with perceived efficacy	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-09	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-88c4zpy	<NULL>	Inclusion Criteria group I participant of both sexes aged 18 and 60; participants with mouth ulcers; participants with mild gingivitis; participants who use orthodontic appliances and/or removable prostheses; be a user of products in the same category; participants willing to follow the trial procedures, who have a cell phone capable of use and with access to the internet network and are available for telephone contacts and/or via WhatsApp and teleservices, with internet access on the days and times determined for the assessments ; participants willing to attend the Clinical Research Center for evaluations, if necessary; participants must understand and agree to the Free and Informed Consent Form (e-TCLE) and consent to their participation; group II participants of both sexes aged between 6 months and 1 year; participants in the first teething phase; vaccination card (updated and up to date); intact skin of the analysis region; be a user of products in the same category; parents or legal representative willing to follow the trial procedures, who have a cell phone capable of use and with access to the internet network and are available for contact by telephone and/or via WhatsApp and teleservice, with internet access on determined days and times for assessments; parents or legal representative of participants willing to attend the Clinical Research Center for evaluations, if necessary, parents or legal representatives of participants must understand, agree and sign the Free and Informed Consent Form (e-TCLE)	Pregnancy or risk of pregnancy/lactation (when women) – for group I; use of anti inflammatory/immunosuppressive/antihistamine drugs up to 3 weeks before selection; skin marks in the experimental area that interfere with the assessment of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevus, sunburn); history of allergies to medical products; active skin pathologies and/or lesions (local and/or disseminated) in the assessment area; immunosuppression by drugs or active diseases; decompensated endocrinopathies; relevant or current clinical history of evidence of alcohol or other drug abuse (for group I); known history or suspected intolerance to products in the same category; aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; intense sun exposure up to 15 days before the assessment; employees or children of employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher to be reasonable for disqualification from participation in the study; If yes, it should be described in observation in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-9zjghmk	Effect of Intravascular Laser Irradiation of Blood (ILIB) Laser on muscle damage, funcitional capacity and biomarkers in atheletes	Recruitment completed	Intervention	2024-08-28	<NULL>	<NULL>	7285	Effect of ILIB laser on muscle damage, functional capacity and biomarkers in athletes	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-16	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9zjghmk	<NULL>	Both sexes; age between 16 and 30; sign the Free and Informed Consent Form (FICF) for athletes over 18 years of age; sign and Informed Consent Form (ICF) for athletes under 18 years of age	Functional (musculoskeletal) incapacity; be undergoing of treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-2w5gczv	Cardiopulmonary resuscitation training: how practice in simulations can contribute improve cardiopulmonary arrest care	Data analysis completed	Intervention	2024-08-28	<NULL>	<NULL>	7286	Learning, satisfaction and self-confidence of nursing professionals submitted to different teaching methods (traditional or realistic simulation) of cardiopulmonary resuscitation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Fundação Cristiano Varella	Fundação Cristiano Varella	https://ensaiosclinicos.gov.br/rg/RBR-2w5gczv	<NULL>	Nursing professionals recently hired by the institution, within up to 90 days of admission; both genders; aged between 19 and 47 years	Incomplete filling out of assessment instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-9q6yb9p	Effects of protein supplementation on body composition of obese women with breast cancer undergoing chemotherapy	Not yet recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7287	Effects of supplementation with isolated whey protein on the body composition of obese women with breast cancer undergoing chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-30	Centro Estadual de Oncologia	Fundação Oswaldo Cruz - Fiocruz Bahia	https://ensaiosclinicos.gov.br/rg/RBR-9q6yb9p	<NULL>	Women; aged &gt;=18 years; diagnosed with invasive breast carcinoma stages I to III; already initiated neoadjuvant or adjuvant systemic chemotherapy treatment; Body Mass Index (BMI) &gt;=30kg/m2	Women diagnosed with associated metastasis; severe obesity (BMI &gt;=40kg/m2); allergy to milk proteins; conditions that affect body water composition such as edema; conditions that affect muscle mass such as muscular dystrophy; limb amputation; pregnancy; use of pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-10kb7t97	Effect of Osteopathic manipulative treatment on patients who have alterations in the Temporomandibular region and associated Gingivitis	Recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7288	Repercussions of Osteopathic manipulative treatment in patients with Temporomandibular Disorder and associated Gingivitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Escola de Osteopatia de Madrid-Brasil Ltda	Escola de Oteopatia Madrid- Brasil LTDA	https://ensaiosclinicos.gov.br/rg/RBR-10kb7t97	<NULL>	Population of men and women aged 20 to 50; Pain in the Temporomandibular Joint and/or in the masseter, temporal and cervical muscles, with or without biomechanical limitation of the range of motion of the Temporomandibular Joint; Presence of gingivitis, with the following clinical findings: localized (10-30%) or generalized (above 30%) gingival bleeding, depth of up to 3mm, without diagnosed bone loss, with or without edema (CHAPPLE et al., 2018) ; Agree and sign the Informed Consent Form	Have undergone treatment or are undergoing treatment for Temporomandibular Disorder in the last six months; Use of orthodontic appliance; Disclosed depression; Cognitive and neurological changes; Diagnosis of Immune Compromised; Pregnancy; History of surgeries apparently less than a year ago; Smokers; Periodontitis; Use of anxiolytics to treat anxiety; Use of antibiotics for three months; Diagnosis of hiatal hernia; Recent scar, mainly on the abdomen and chest	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-8hfzh3t	Evaluation of Bone Formation after tooth extraction in sockets treated with Platelet- and Leukocyte-Rich Fibrin alone or associated with Synthetic Graft	Recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7289	Histomorphometric analysis of the bone neoformation process in fresh sockets treated with fibrin rich in platelets and leukocytes associated with a synthetic graft: in vivo comparative study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-13	Faculdade de Odontologia	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8hfzh3t	<NULL>	Individuals of both sexes aged between 18 and 70 years will be included, with the need for extraction and installation of implants in the second surgical stage, patients with bone remaining &lt; 3 mm up to the anterior nasal fossa; maxillary sinus and mandibular canal; patients presenting alveoli with four bony walls intact	individuals with uncontrolled systemic disorder that could interfere with bone healing; using bisphosphonates; denosumab; using corticosteroids; who received therapeutic radiation to the head and neck region in the last five years; history of heavy smoking &gt;10 cigarettes per day; immunosuppression; individuals with poor oral hygiene and pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-29xt8nh	Use of the Etonogestrel implant in women with kidney transplant to prevent pregnancy.	Not yet recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7290	Etonogestrel Implant in Kidney Transplant	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Irmandade da Santa Casa de Misericórdia de Porto Alegre	Irmandade da Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-29xt8nh	<NULL>	Kidney transplant women between 14 and 49 years old; carry out follow-up at the Gynecology outpatient clinic of Santa Casa de Porto Alegre; desire for etonogestrel implant insertion	Kidney transplant less than 6 months ago; use of medroxyprogesterone in the last 6 months; patients in organ rejection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-10gbvjyb	Effect of creatine supplementation on physical performance in physically active women	Data analysis completed	Intervention	2024-08-28	<NULL>	<NULL>	7291	Effects of Creatine Supplementation on Muscle Strength during a Session of Concurrent Training on active women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-10gbvjyb	<NULL>	Being female. Have a normoprotein or hyperprotein diet; Be a practitioner of physical exercise (at least three times/week strength training and at least once/week aerobic exercise); recent strength and aerobic training experience of at least six months; age between 19 and 59 years old	Use of a creatine supplement in the last six months; being using anabolic steroids or steroids; being taking medications that can affect muscle biology (corticosteroids); have kidney disease; have liver disease; be allergic to milk; eggs and/or soy (according to the creatine marketer&apos;s instructions); perform some additional physical exercise that is not part of your daily routine before the protocol; take anti-inflammatories (medication) during the current study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-6s332z3	Malignant Hyperthermia and Kidney Transplantation	Data analysis completed	Observational	2024-08-28	<NULL>	<NULL>	7292	Anesthesia for Malignant Hyperthermia in the context of Kidney Transplantation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-10-05	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6s332z3	<NULL>	Patients scheduled for living donor kidney transplantation; living patients scheduled for total nephrectomy for donation; both sexes	Patients with a previous history of intraoperative awakening; family or personal history of susceptibility to malignant hyperthermia (MH); contraindications to the use of halogenated inhaled anesthetics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-3b3fc72	Evaluation of the effect of using Adjustable Tables on Posture problems, Body Pain, and Caloric Expenditure in high school adolescents: a crossover clinical trial	Not yet recruiting	Intervention	2024-08-28	<NULL>	<NULL>	7293	Evaluation of the effect of using Standing Desks on Postural Deviations, Musculoskeletal Pain symptoms, and Energy Expenditure in high school adolescents: a crossover clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal do Rio Grande (FURG)	Universidade Federal do Rio Grande (FURG)	https://ensaiosclinicos.gov.br/rg/RBR-3b3fc72	<NULL>	Second year high school students; aged 14 to 21; both sexes; duly enrolled in the year 2024 at the Federal Institute of Rio Grande do Sul - IFRS, Rio Grande campus; who agree to participate in the study	Students with physical and/or cognitive limitations that prevent them from completing self-administered questionnaires and carrying out physical assessments and postural assessments on their own; students who are pregnant or breastfeeding;  students outside the age range of 14 to 21	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-10mk5gvb	Efficacy and safety of the combined use of a bioestimulator and ultrasound for improvement of facial sagging	Not yet recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7277	Efficacy and safety of the combined use of Poly-L-lactic acid and Microfocused Ultrasound for improvement of Facial Sagging: a randomized, triple-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2025-12-15	Fernanda Almeida Nunes Castro	Angioderm Centro de Estética Ltda	https://ensaiosclinicos.gov.br/rg/RBR-10mk5gvb	<NULL>	Healthy women, 35 and 50 years old, with mild to moderate facial laxity.	facial surgical scar; history of herpes simplex infection; active or systemic infection;  non-steroidal anti-inflammatory drugs use; anticoagulants use; steroids use; heparin; vitamin K or E within the last 30 days prior to the study; pregnancy; breastfeeding; any clinical condition and or laboratory abnormality; previous aesthetic procedures with biostimulators or physical resources such as laser, radiofrequency and or ultrasound on the face in the last 3 years; injection of permanent materials in the face anytime	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-4j5ph5m	Evaluation of the reduction of dental whitening time to control dental sensitivity in adolescents	Not yet recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7278	Evaluation of reducing dental bleaching time to control dental sensitivity in adolescents: double blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4j5ph5m	<NULL>	good general and oral health; be between 12 and 16 years old; at least six upper front teeth free of active caries and endodontic treatment; Canines (13,23) should be A2 color or darker.	Patients undergoing orthodontic treatment; patients with dental prostheses; severe tooth discoloration (tetracycline stains, fluorosis or devitalized teeth); pregnant and lactating patients; participants who have already undergone teeth whitening.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-2xq4vw4	Effects of low oxygen intervals during exercise on human body function	Recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7280	Effects of intermittent hypoxia recovery on molecular, metabolic and neuromuscular variables	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2xq4vw4	<NULL>	Man; healthy; aged 18 to 35 years old	History of anemia in the last six months; history of lower limb injury in the last six months; and presented low ferritin levels at the beginning of the experiment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-74mwqjw	Preoperative Telenursing in Outpatient Surgery	Recruitment completed	Intervention	2024-08-27	<NULL>	<NULL>	7281	Nursing Teleconsultation in Preoperative Outpatient Surgery: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Faculdade de Enfermagem da Universidade do Estado do Rio de Janeiro	Programa de Pós-graduação em Enfermagem da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-74mwqjw	<NULL>	Patients in pre-operative care for outpatient surgery; age over 18; both genders; able to answer telephone calls	Patients who did not respond to one of the three telephone contact attempts	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-3pt3k6d	Fascia manipulation study	Recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7283	Evaluation of the acute effect of different fascia manipulation techniques in young adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3pt3k6d	<NULL>	Men and women; age betwen 18 and 35 years old; Practice regular resistance exercise; two to five times a week for one hour a day; No injury or trauma to the lower limbs in the last three months, which would prevent the practice of physical activity; Not having had any knee surgery; Independent and lame-free gait for 100 or more meters; No restrictions on the practice of resistance exercises; Not have uncontrolled hypertension; Do not present cardiovascular restrictions to practice physical activity; Body Mass Index below 30	Inability to perform any of the tests. Systolic blood pressure equal to or above 160mmHg and diastolic blood pressure equal to or above 120mmHg at the time of the test or during exercise. Do not tolerate fascial manipulation or myofascial release with the roller	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-656kdr2	Efficacy of Diaphragmatic Release on airflow in individuals with Parkinson&apos;s Disease: randomized controlled clinical trial	Not yet recruiting	Intervention	2024-08-27	<NULL>	<NULL>	7284	Study of the effect of the Myofascial Release Technique of the diaphragm on the airflow of individuals with Parkinson&apos;s Disease: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-656kdr2	<NULL>	Adult men and women (over 18 years old); with early-stage Parkinson&apos;s Disease (PD) (modified Hoen &amp; Yahr scale 0-2.5); undergoing regular pharmacological medical treatment for PD with the use of Levodopa; physical and understanding conditions for carrying out the research; no smoking; absence of respiratory diseases or other diagnosed neurological diseases	Participants who miss 3 continuous sessions and those who are unable to perform the tests properly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-7g2d86j	Evaluation of a new infant formula on the growth and tolerance of healthy infants	Recruitment completed	Intervention	2024-08-26	<NULL>	<NULL>	7263	Evaluation of the effects of a new infant formula on growth, gastrointestinal tolerance and morbidity of healthy infants	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Nestlé Brasil Ltda	Hospital e Maternidade São Luiz	https://ensaiosclinicos.gov.br/rg/RBR-7g2d86j	<NULL>	Healthy infants; with 0 to 14 days old; born at term (gestational age between 37 and 42 weeks); who had a birth weight between 2500 and 4500g; exclusively breastfed or exclusively artificially breastfed	Infants on mixed breastfeeding; infants who start complementary feeding before 4 months of age; infants with congenital disease or malformation that may affect growth; severe prenatal or postnatal illness prior to inclusion;  parents under 18 years old; parents not expected to comply with study procedures; and current or previous participation in another clinical study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-7rg7479	Effect of abdominal Elastic Tape after Cesarian Section	Recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7264	Effect of abdominal taping after cesarian section	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-12	Fundação Educacional Lucas Machado FELUMA	Hospital Mater Dei- Betim/Contagem (HMD-BC)	https://ensaiosclinicos.gov.br/rg/RBR-7rg7479	<NULL>	Postpartum women over 18 years of age with up to 48 hours post-cesarean section; no indwelling bladder catheter; adults hospitalized for obstetric care at the Maternity Hospital of the MaterDei-Betim Hospital/Contagem HMD-BC	Skin diseases or active wounds in the abdominal region; height of the fundus of the uterus above the umbilical line; hemorrhages; laparotomic or other open abdominal surgeries, excluding previous cesarean sections; not literate; not understanding the researchers’ instructions; refuse to sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-5cf7vzj	Effect of a vaginal gel on menopausal women with breast cancer	Recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7265	Evaluation of the effectiveness of a non-hormonal vaginal moisturizer gel on vaginal and sexual health in postmenopausal women with breast cancer	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-05	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Hospital das Clínicas da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5cf7vzj	<NULL>	Women; date of last menstruation at least 12 months ago;  age between 45 and 65 years old; histological diagnosis of breast cancer; completed cancer treatment; except adjuvant endocrine therapy; stage I, II and III;  sexually active;  presence of vaginal symptoms of menopausal geniturinary sindrome; ability to understand and consent to your participation in the study	Stage IV and or metastatic disease will be excluded;  current radiotherapy or chemotherapy; alcoholic or drug addicts;  current use of vaginal moisturizers;  use of vaginal estrogen in the previous six months;  infection of the lower genital tract; cognitive deficit; illiteracy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-5g64wy4	Comparison of the use of Tens associated with Pilates in Chronic Low Back Pain	Not yet recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7266	Comparative analysis of association of Tens with the Pilates Method in Chronic Low Back Pain: randomized, sham-controlled and double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-10	Centro de ciências da saúde da Universidade Federal da Paraíba	Centro de ciências da saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5g64wy4	<NULL>	Volunteers aged between 18 and 85 years old; of both sexes; with a primary diagnosis compatible with nonspecific low back pain (low back pain without other specification); with a pain intensity score of 3 or higher on the Numerical Rating Scale (NRS); who have not undergone previous surgery in the lumbar region; who have no skin lesions; who do not have a pacemaker; who have not used medication for low back pain relief within 48 hours prior to the intervention; who are not undergoing treatment for low back pain; and who agree to participate in the research by signing the Informed Consent Form	Develop a health disorder during the study. Present allergic reactions to the electrical current generated by the therapeutic resource	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-7f7gf43	Evaluation of the efficacy of chlorhexidine with an antidiscoloration system after third molar surgery	Recruitment completed	Intervention	2024-08-26	<NULL>	<NULL>	7267	Clinical study of the effect of chlorhexidine with an antidiscoloration system after extraction of third molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal do Espiríto Santo	Universidade Federal do Espiríto Santo	https://ensaiosclinicos.gov.br/rg/RBR-7f7gf43	<NULL>	Indication for extraction of the two erupted maxillary third molars; age over eighteen years; both genders; healthy;  good oral hygiene; non-smokers; non-drinkers; absence of cracks in the enamel, cavities and restorations in teeth upper central incisors; color of upper incisors corresponding to at least Shade A3 on the Vita Classical shade guide	Pregnant women and postpartum women; chronic systemic diseases, such as uncontrolled diabetes and infectious diseases; history of hypersensitivity or allergic response to components of the mouthwash formulas under study; orthodontic treatment; periodontal disease; upper incisors stained by tetracycline or fluorosis; patients with fixed or removable dental prostheses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-9gm2fgf	Assessment of the quality of life of people who had lower Wisdom tooth Extraction	Terminated	Intervention	2024-08-26	<NULL>	<NULL>	7268	Assessment of the quality of life of individuals undergoing Extraction of impacted Third Molars in the mandible	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9gm2fgf	<NULL>	Adults aged between 18 and 45, of both sexes; in ASA in group I; with indication of bilateral extraction of lower third molars; The right and left lower third molars of the included individuals must present the same degree of inclusion according to the classification of Pell and Gregory (1933) determined by means of panoramic radiography or cone beam computed tomography	Patients who are allergic to NSAIDs (nimesulide or etoricoxib) and/or corticosteroids (dexamethasone); signs of infection at the surgical site; chronic users of analgesics and/or anti-inflammatories; smokers; pregnant or breastfeeding women; patients who did not fit into the surgical or anesthetic planning and patients who withdrew from participating in the research at any time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-2rh5djy	The effect of an application in speech recognition in noise and listening effort in individuals with hearing loss	Recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7269	Efficacy of a hearing accessibility app and a digital remote microphone system in speech recognition in noise and listening effort in individuals with sensorineural hearing loss: clinical, randomized, double-blind trial	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-14	Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2rh5djy	<NULL>	Hearing aid users for at least six months; have sensorineural hearing loss of any degree; be over 18 years old; have your hearing aid working correctly; Participants must adhere to the Free and Informed Consent Form; there is no gender distinction	Have conductive and or mixed hearing loss; indication of neurological dysfunction in the medical record; not be able to test in noise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-9qm8wqh	Remote Monitoring for Pelvic Floor Muscle Strengthening in Pregnant Diabetic Women	Not yet recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7270	Use of Telemonitoring to Train the pelvic floor muscles of Diabetic pregnant women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Maternidade Escola Januário Cicco	https://ensaiosclinicos.gov.br/rg/RBR-9qm8wqh	<NULL>	Women; age between 18 and 45 years; diagnosis of Gestational Diabetes Mellitus, according to the criteria of the World Health Organization; gestational age between 14 and 21 weeks identified by first-trimester ultrasound; having attended a maximum of three consultations in High-Risk Prenatal Care; medical clearance to perform exercise; access to a smartphone; interest in participating in any of the interventions	Prescription of insulin therapy upon recruitment; multiple pregnancy; chronic arterial hypertension at recruitment; pre-eclampsia at recruitment; history of intrauterine fetal death or multiple miscarriages; orthopedic limitation; alcohol consumption doses of alcohol per week; smoking; neurological, language, hearing and/or visual limitations that may make participation in the study difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-35x4fz7	Skin irritation and sensitization due to intimate lubricant	Recruitment completed	Intervention	2024-08-26	<NULL>	<NULL>	7271	GRC161-24 Dermatologist-supervised assessment of primary and cumulative irritation potential, skin sensitization potential for investigational product intimate lubricant	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-22	Kosmoscience Ciência e Tecnologia Cosm Imp Exp LTDA	Kosmoscience Ciência e Tecnologia Cosm Imp Exp LTDA	https://ensaiosclinicos.gov.br/rg/RBR-35x4fz7	<NULL>	Healthy research participant; age range between 18 and 70 years old; gender: female and male; phototype: I to IV. fitzpatrick classification; agreement not to wet the area during the entire test period; understand the test procedures and agree to adhere to the study requirements; absence of inflammatory dermatoses or tattoos at the application site; signing of the Free and Informed Consent Form (TCLE)	Pregnancy, lactation; presence of localized or generalized dermatological diseases; presence of active inflammatory dermatoses in the test region; frequent exposure to the sun or tanning beds; have participated in an allergenicity study within a period of less than four weeks from the start of the study; research participants with a history of allergy to the material used in the study; history of atopy; history of pathologies aggravated or triggered by ultraviolet radiation; people with immunodeficiencies; forecast of intense sun exposure or tanning session during the study period; anticipated bathing in the sea, swimming pool or sauna during the study; research participants who practice water sports; dermographism; use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to 2 weeks before selection; treatment with acid vitamin A and/or its derivatives orally or topically up to 1 month before the start of the study; aesthetic and/or dermatological body treatment up to 3 weeks before selection; expected vaccination during the study or up to 3 weeks before the study; any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study; history of lack of adherence or unwillingness to adhere to the study protocol; professionals directly involved with the research center and sponsor in carrying out this protocol and their families; be participating in another study at the time; any condition that, in the researcher&apos;s opinion, could compromise the study (describe)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-9j53g4r	Effectiveness of the vaccine that protects against four different types of the dengue virus (QdengA) in the Municipality of Rio de Janeiro	Recruiting	Observational	2024-08-26	<NULL>	<NULL>	7272	Effectiveness of the Attenuated Chimeric Tetravalent Dengue Vaccine (QDenga) in the Municipality of Rio de Janeiro	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-16	Secretaria Municipal de Saúde do Rio de Janeiro	Secretaria Municipal de Saúde do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9j53g4r	<NULL>	Individuals of both genders; aged 18 to 59 years; residing in the Administrative Region (RA) of Guaratiba in the Programatic area (AP) 5.2 of the city during the inclusion period; Who agree to participate in the research	Individuals with immunosuppression; pregnant or lactating individuals; participants who have received any blood product in the last 3 months or have had a hypersensitivity reaction to any component of the vaccine; participants who have previously received any dengue vaccine; individuals with an acute febrile illness, or those who have received another live virus vaccine in the last four weeks will have their inclusion postponed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-783g4zj	Evaluation of manual therapy technique in women with breast cancer during radiotherapy	Not yet recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7273	Evaluation of the safety and efficacy of manual therapy in women with breast cancer during the radiotherapy treatment period	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-19	Centro Estadual de Oncologia - CICAN	Fundação Oswaldo Cruz - FIOCRUZ/ Instituto Gonçalo Moniz - IGM	https://ensaiosclinicos.gov.br/rg/RBR-783g4zj	<NULL>	Women with breast cancer; over 18 years old; treated surgically with conservative surgeries; mastectomy; with or without axillary dissection and referral for adjuvant radiotherapy sessions with moderate hypofractionation (conformational technique - 3D); who respond to the DASH questionnaire; the care questionnaire; will be included in the study; with the skin; to the Free and Informed Consent Form (ICF) and Image Use Authorization Term	Women who have difficulty understanding or answering the questionnaires used; patients undergoing immediate breast reconstruction; problems or orthopedic surgeries on the ipsilateral limb; grade 3-4 radiodermatitis; referred for 2D conventional radiotherapy and intensity modulated radiotherapy (IMRT) sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-4s4fnqc	Application of Elastic Bandage after fat aspiration surgery from the abdominal region and flanks in women: randomized clinical trial	Recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7274	Application of Taping in the Immediate Post-Operative after plastic surgery in women undergoing Liposuction in the abdominal and flank region: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-11	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4s4fnqc	<NULL>	Be female; individuals aged 20 and 70; have an indication for surgical treatment of liposuction of the abdominal region and flanks for breast fat grafting; understand the objectives and instruments used in the research	Have an allergy to the taping tape; have uncontrolled diabetes; have neurological diseases (e.g. Parkinson&apos;s Disease, Multiple Sclerosis, etc.); present chronic use of anti-inflammatory and diuretic medications in the last 3 months; present psychological disorders that impede understanding of the research and assessment instruments; Participants who develop infections, hemorrhages, bruises or other complications in the postoperative period will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:58
RBR-2nktkhd	Effect of Task-Oriented Therapy, motor enrichment (Time-Baby) on motor development of infants at biological risk for neurodevelopmental delay: Randomized controlled clinical trial	Recruiting	Intervention	2024-08-26	<NULL>	<NULL>	7275	Effect of Task-Oriented Therapy associated with environmental enrichment on the motor development of infants at biological risk for neurodevelopmental disorders: Randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Centro de Ciências Biológicas e da Saude - CCBS	Universidade Federal de São Carlos - UFSCAR	https://ensaiosclinicos.gov.br/rg/RBR-2nktkhd	<NULL>	Infants of both sexes, aged between 3 and 6 months corrected age, who are considered to be at biological risk by the Ministry of Health, i.e., who present one of the following criteria, will be included in the study: 1) prematurity (&lt;37 weeks of gestational age); 2) low birth weight (&lt;2500 g); 3) Asphyxia (Apgar &lt;7 at 5 min); and the acceptance of the parents and/or legal guardians will be required, by means of signing the Free and Informed Consent Form (TCLE)	Infants who do not present at least one of the criteria for biological risk factors; those who present decompensated respiratory and/or cardiac dysfunctions; parents who present any cognitive or motor impairment that prevents understanding and carrying out the intervention; and infants who do not attend the evaluations will not be included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-89w7hc2	Cortical activity assessment and the use of Virtual Reality for rehabilitation and cortical activity assessment in patients who had stroke episodes	Data analysis completed	Intervention	2024-08-26	<NULL>	<NULL>	7276	Cortical connectivity assessment and Virtual Reality intervention for rehabilitation of stroke patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Instituto de Física Gleb Whatagin	Hospital Geral do Grajaú	https://ensaiosclinicos.gov.br/rg/RBR-89w7hc2	<NULL>	Patients who suffered a stroke (type 1); patients who have hemeparesis as a consequence of the stroke; both female and male gender patients; patients above 18 years old	Patients who are confused and disoriented; patients who have comprehension aphasia; patients without any motor deficit; patients who have claustrophobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-44k3f3x	Assessment of bleaching efficacy using two concentrations of carbamide peroxide in home bleaching in adolescents	Not yet recruiting	Intervention	2024-08-23	<NULL>	<NULL>	7261	Assessment of bleaching efficacy using two concentrations of carbamide peroxide in home bleaching in adolescents: double-blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-09-02	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-44k3f3x	<NULL>	Good general and oral health; 12 to 16 years old; Six upper anterior teeth free of active caries and endodontic treatment; restorations of a maximum of 1/3 of the dental structure; canines (13,23) should be A2 color or darker.	Participants undergoing orthodontic treatment; dental prostheses; severe tooth discoloration (tetracycline stains, fluorosis or devitalized teeth); pregnant and lactating patients, continuous users of anti-inflammatories or analgesics; participants who have already undergone teeth whitening procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-4zvg678	Effect of Propolis Extract Supplementation and Combined Training on Chronic Low-Grade Inflammation and Oxidative Stress in Postmenopausal Overweight and Obese Women	Not yet recruiting	Intervention	2024-08-23	<NULL>	<NULL>	7262	Propolis and Exercise Training combined on Chronic Low-grade Inflammation and Oxidative stress in Overweight and Obese Postmenopausal Eomen	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-20	Pró Reitoria de Pesquisa da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4zvg678	<NULL>	Women aged between 60-79 years;  BMI between 25 and 30 kg/m2; not practicing resistance training (&gt; 6 months without practice); without weight change in 6 months; non-smoker for more than 1 year; without history of cancer, cardiorespiratory disease, uncontrolled hypertension (SBP ≥160 mmHg and DBP ≥120 mmHg)	Have any gastrointestinal discomfort or hypersensitivity to the use of propolis supplementation; have any musculoskeletal discomfort with combined training;not perform the proposed tests before and after the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-3j6jwg3	Clinical trial to evaluate intralesional Meglumine Antimoniate associated with topical Imquimod in the treatment of Cutaneous Leishmaniasis	Recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7253	Randomized clinical trial to evaluate the efficacy and safety of Intralesional Meglumine Antimoniate associated with topical Imiquimod in the treatment of Cutaneous Leishmaniasis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2024-06-20	Empresa Brasileira de Serviços Hospitalares - EBSERH	Empresa Brasileira de Serviços Hospitalares - EBSERH	https://ensaiosclinicos.gov.br/rg/RBR-3j6jwg3	<NULL>	Diagnosis of CL with up to 3 lesions, up to 5 cm in diameter, ulcerated or not, with confirmation by one or more methods (direct examination, histopathology, culture, polymerase chain reaction, indirect immunofluorescence or Montenegro intradermal staining), without previous treatment or treated more than 6 months ago; age greater than or equal to 18 years; both sexes; hormonal and barrier contraceptive method, in the case of female patients of childbearing age; completion of the free and informed consent form (TCLE)	Other forms of acute tegumentar leishmaniasis other than cutaneous; injuries located on the cephalic segment; pre-treatment electrocardiographic changes that contraindicate the use of pentavalent antimony; women of reproductive age without an effective contraceptive method or used inappropriately; pregnant and breastfeeding women; diagnosis of human immunodeficiency syndrome (AIDS); previous hypersensitivity reaction to AM or imiquimod; inability to understand and complete the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-5m3yxmb	Evaluation of the function of potential molecules important for alterations in blood sugar and the immune system of individuals with type 2 Diabetes Mellitus and Periodontitis	Recruitment completed	Intervention	2024-08-22	<NULL>	<NULL>	7254	Search for health markers observed after periodontal treatment of patients with type 2 Diabetes Mellitus	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara	Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-5m3yxmb	<NULL>	Individuals aged between 30 and 70 years were included. For this sample, individuals of both sexes were selected. They should have at least 15 teeth in the oral cavity and could be from any ethnic-racial group. For the group with type 2 diabetes mellitus, participants would have the diagnosis confirmed by the attending physician	Individuals with a history of hepatitis and Human Immunodeficiency Virus infection (HIV), anemia, antibiotic pre-medication in the last 6 months, or chronic use of anti-inflammatory drugs were excluded, as well as pregnant or lactating research participants. Regarding type 2 diabetes mellitus, prediabetic individuals and research participants with type 2 diabetes mellitus using thiazolidinedione medications such as rosiglitazone, pioglitazone, and roglitazone were also excluded, as these activate natural Peroxisome Proliferator Activated Receptor Gamma (PPARG)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-388nknt	Efficacy of Gamaline V Medication to Improve Breast Pain in Women: a Comparative Research Between Groups	Recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7255	Efficacy of Gamaline V in Reducing the Intensity of Mastalgia in Female Patients: a Randomized Clinical Trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-388nknt	<NULL>	Women; over 18 years of age; complaining of breast pain	Breast cancer patients; people with schizophrenia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-5ty2pnv	COVID-19 Pandemic and Tuberculosis Control in the State of São Paulo: Monitoring by Telemonitoring	Not yet recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7256	Impact of COVID-19 on tuberculosis control in the state of São Paulo - Brazil: Analysis of morbidity and mortality indicators and coping strategies through digital health.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5ty2pnv	<NULL>	New cases of tuberculosis. Over 18 years old. No gender criteria. Own a smartphone (intervention group). Health professionals responsible for Directly Observed Treatment (DOT) and/or monitoring of people with tuberculosis. Unit managers (Primary Health Care (PHC) coordinators and/or tuberculosis program coordinators of the health units in the municipalities, previously selected)	Resistant Tuberculosis. Professionals and/or managers who have been in the position or working with tuberculosis for less than 6 months. Unavailability of individual or family cell phone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-3g96g2v	Use of Video with Simulation to reduce Anxiety in a Patient Undergoing a Cardiac Procedure	Recruitment completed	Intervention	2024-08-22	<NULL>	<NULL>	7257	Efficacy of a Simulated Video on the State anxiety score and cardiorespiratory parameters of patients undergoing Percutaneous Cardiac Procedure: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-07	Programa de Pós-Graduação strictu sensu em Atenção à Saúde	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-3g96g2v	<NULL>	Patients undergoing coronary angiography with the possibility of conversion to ad hoc angioplasty and elective or emergency percutaneous transluminal coronary angioplasty aged 18 years or older; of both sexes	Patients who are using sedative or anxiolytic medications at the time of data collection will be excluded from the study; and who are unable to maintain dialogue with the researcher to answer the items in the data collection instrument	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-7r6z2nk	Effects of physical exercise on the health of the heart, blood vessels and muscles in older adults	Not yet recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7258	Effects of exercise training on cardiovascular, functional, metabolic, inflammatory parameters, and body composition of older adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-7r6z2nk	<NULL>	Individuals aged 60 years or older gender both sexes; not participating in any supervised physical training program in the last 6 months; availability to perform physical exercises twice a week; not having undergone recent surgery; not having chronic obstructive pulmonary disease; feeling pain; nor having an orthopedic injury that prevents participation in the experiment; for example, joint instability; dislocation; recent fractures; severe contracture in muscles of the lower limbs	Present nausea; dizziness; discomfort; fainting; or excessive sweating; miss one of the assessments; request to leave the intervention program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-424gzzy	Evaluation of the Chemical and Mechanical Properties of Invisible Orthodontic Aligners: A Laboratory and Human Study	Not yet recruiting	Observational	2024-08-22	<NULL>	<NULL>	7259	Evaluation of the chemical and mechanical properties of orthodontic aligners: in vitro and in vivo study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-09-16	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-424gzzy	<NULL>	Individuals between the ages of 18 and 30; both genders; systemically healthy; with good oral hygiene; with the presence of dental malocclusion; healthy periodontium and absence of dental caries	Individuals under 18 years of age, with serious systemic alterations; using medications that may cause alterations in salivary flow; using antibiotics and anti-inflammatory drugs in the last 03 months; abnormal/non-healthy periodontium and presence of dental caries; individuals with clinical signs of parafunctional habits, free of malocclusion, and who underwent restorations in the last 12 months will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-6pygc5m	Effects of the Laser on the lips	Recruiting	Intervention	2024-08-22	<NULL>	<NULL>	7260	Effects of Myotherapy combined with Photobiomodulation on the lips: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal de Minas Gerais	Universidade Vale do Rio Doce	https://ensaiosclinicos.gov.br/rg/RBR-6pygc5m	<NULL>	Healthy individuals of both genders; aged between 18 and 35 years; who have signed the Informed Consent Form (ICF); have not used muscle relaxants and/or anti-inflammatory medication in the 48 hours preceding data collection; participants without contraindications for phototherapy	Non-execution of all proposed tasks; low quality of electromyographic signal; not have dento-skeletal conditions to perform lip sealing or those who; lip sealing with effort	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-7jmc5yw	Opinion of transgender men living in Brazil on the outcomes of Masculinizing Mammoplasty	Recruiting	Observational	2024-08-21	<NULL>	<NULL>	7243	Perception of transgender men living in Brazil regarding the results of Masculinizing Mammoplasty	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7jmc5yw	<NULL>	Transgender men living in Brazil; candidates for masculinizing mastectomy; aged 18 years or older; body mass index (BMI) between 18 and 35 kg/m2	Illiterate individuals or those unable to read the questionnaire; diagnosis of cognitive, neurological, or psychiatric disorder that may hinder questionnaire completion; physical disability that may prevent questionnaire completion; refusal to participate or withdrawal of consent at any stage of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-458mtdb	Effect of reiki on the subjective well-being of nursing professionals in an emergency: randomized clinical trial	Data analysis completed	Intervention	2024-08-21	<NULL>	<NULL>	7244	Evaluation of the effect of reiki on the subjective well-being of nursing professionals in emergency services: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-458mtdb	<NULL>	Both genders; minimum age of 18; nursing professionals with at least three months work in the unit	Nursing professionals who are away for various reasons (vacation, leave, health, pregnancy); those who are merely replacing another professional in the unit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-4gkyw46	Evaluation of gingiva and bone after deep margin elevation restoration compared to crown lengthening surgery	Recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7245	Deep margin elevation and clinical Crown lengthening	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-4gkyw46	<NULL>	Individuals over 18 years of age; in good general health; male or female; with teeth that require restorations that invade the supracrestal insertion tissues in the mesial or distal region; posterior teeth that can be restored with direct resin	Patients with periodontal disease; smokers; diabetics; immunocompromised; pregnant women; who use antiresorptives; teeth in which it was not possible to perform absolute isolation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-10c447x8	Evaluating the Effect of Acupuncture on Temporomandibular Joint Disorder pain control	Recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7246	Evaluation of Acupuncture effects on painful Temporomandibular Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-07	Núcleo de Pesquisa e Desenvolvimento de Medicamentos	Núcleo de Pesquisa e Desenvolvimento de Medicamentos	https://ensaiosclinicos.gov.br/rg/RBR-10c447x8	<NULL>	Women; over 18 years of age; diagnosed with painful Temporomandibular Dysfunction of the muscular or mixed type; who report pain of intensity at least 4 on the numerical pain scale (NDS); for at least 3 months	other orofacial pain; smokers; presence of gingivitis with spontaneous bleeding; periodontitis; oral lesions; diseases affecting the adrenal glands; pregnant and lactating women; use of glucocorticoids and medications and/or supplements that affect cortisol levels less than 3 months before inclusion in the study (anticonvulsants; tricyclic antidepressants and/or monoamine oxidase inhibitors; estrogen receptor antagonists; antifungals; progesterone antagonists; diuretics; opioid analgesics and immunosuppressants); total edentulousness and partial edentulousness with presence of free end; refusal to sign the informed consent form; physical or psychological alterations that prevent the use of the assessment instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-2mkqqpj	Gynecological acceptability of intimate lubricant product	Recruitment completed	Intervention	2024-08-21	<NULL>	<NULL>	7247	GRC161-24 Clinical trial to evaluate the safety of the investigational product intimate lubricant, through assessment of gynecological acceptability under normal conditions of use	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-22	Universidade São Francisco - USF	Universidade São Francisco - USF	https://ensaiosclinicos.gov.br/rg/RBR-2mkqqpj	<NULL>	Age range between 18 and 65 years; phototypes: I to VI, according to Fitzpatrick classification; female gender; intact skin in the evaluation region; intact mucosa in the evaluation region; agree to adhere to the study procedures and requirements: study time, return(s) to the laboratory to perform the study procedures, single application of the investigational product at Kosmoscience by the client&apos;s professional, not to change habits including hygiene during the study period; agree not to perform dermatological or aesthetic treatments until the end of the study and agree not to use any products in the same category as the investigational product; signing of the Free and Informed Consent Form (FICF)	Pregnant or lactating women; skin marks in the experimental area that interfere with the evaluation of possible reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, large amounts of freckles and warts, sunburn); active endocrine pathologies such as thyroid disease, diabetes, ovarian or adrenal gland disorders; presence of active local or disseminated vaginal dermatoses in the study region that may interfere with the results; history of ineffectiveness, allergic reactions, irritation or intense discomfort to topical products: health products or medications; expected vaccination during the study or up to 3 weeks before the study; history of chronic or active gynecological pathologies at the time; not taking vitamin A (acid and/or its derivatives orally or topically up to 1 month before the start of the study); carriers of immunodeficiencies; history of atopy (atopic dermatitis, allergic rhinitis, allergic bronchitis, allergic conjunctivitis, etc.); use of non-hormonal anti-inflammatory drugs, corticosteroids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study (or considering depot corticosteroids, the interval should be 1 month before selection); aesthetic or gynecological treatment up to 4 weeks before the study; unstable hormonal treatments in the last 3 months; people directly involved in the performance of this study and their families; history of lack of adherence or unwillingness to adhere to the study protocol; intense sun exposure or tanning session up to 15 days before the initial evaluation; forecast of intense sun exposure or tanning session during the study period; any condition that, in the researcher&apos;s opinion, may compromise the study; participating in another study in the same region of application	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-4733xbn	Daily pause from sedation in very ill children	Recruitment completed	Intervention	2024-08-21	<NULL>	<NULL>	7248	Daily interruption of sedation in children critically sick	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Complexo Hospital de Clínicas Universidade Federal do Paraná	Hospital Universitário Evangélico Mackenzie	https://ensaiosclinicos.gov.br/rg/RBR-4733xbn	<NULL>	Children between zero and eighteen years old; admitted to the pediatric intensive care unit; invasive mechanical ventilation; use of continuous sedative and analgesic medications for at least two days; guardian signs the free and informed consent form	Patients diagnosed with intracranial hypertension; Patients who require neuromuscular blocker for more than two days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-5vcmzfs	Application for the detection of the risk of increased blood pressure at the beginning of pregnancy	Not yet recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7249	Assistance Application for Prediction of Preeclampsia in the First Trimester Gestational Quarter: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-5vcmzfs	<NULL>	Pregnant women over 18 or under 18 who are accompanied by a legal guardian; Unique pregnancy; Pregnancy between 11+0 and 13+6 weeks of evolution	prior kidney disease; Committed physical or mental health that makes interaction with researchers unfeasible at any time of study data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-4vwy5xj	Comparison between moderate load Exercises and high load Exercises in the rehabilitation of runners with Achilles Tendon Pain	Recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7250	Exercises with different intensities for rehabilitation of runners with Achilles Tendinopathy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-15	Faculdade de Ciências da Saúde do Trairi da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4vwy5xj	<NULL>	Amateur runners aged 18 to 60; male; with a clinical diagnosis of tendinopathy of the middle portion of the Achilles tendon	Exclusively insertional Achilles tendinopathy; washout period of less than 4 weeks from other treatments; use of corticosteroid injections in the Achilles tendon region or use of fluoroquinolone antibiotics in the last 12 months; other injuries to the affected lower limb in the last 3 months; musculoskeletal surgery on the spine or lower limbs in the last 12 months; history of Achilles tendon rupture and systemic diseases that may interfere with rehabilitation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-6h72wkn	Evaluation of the association of Antimicrobial Photodynamic Therapy (aPDT) with standard oral hygiene with 0.12% Chlorhexidine in the oral disinfection of critically ill patients	Recruitment completed	Intervention	2024-08-21	<NULL>	<NULL>	7251	Evaluation of the association of Antimicrobial Photodynamic Therapy (aPDT) with Standard Therapy with 0.12% Chlorhexidine in the Oral Disinfection of critically ill patients under mechanical ventilation: a controlled and randomized study	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2022-10-01	Departamento de Anestesiologia, Dor e Medicina Intensiva - Universidade Federal de São Paulo	Departamento de Anestesiologia, Dor e Medicina Intensiva - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6h72wkn	<NULL>	Patients over 18 years of age; both sexes; patients undergoing orotracheal intubation for at least 72 hours; signing an informed consent form	Prospect of death in less than 24 hours or palliative care; patients in the immediate or late postoperative period after head surgery and neck; known allergy to any component of the chlorhexidine formula or to curcuminoids; patients with a history of oropharyngeal neoplasia; trauma patients with facial bone fractures; previous participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-7c4c5jx	Comparing Benzodiazepine-Ketamine and Benzodiazepine-Fentanyl sedation in Cataract surgery	Not yet recruiting	Intervention	2024-08-21	<NULL>	<NULL>	7454	Comparison between Benzodiazepine associated with Ketamine versus Benzodiazepine associated with Fentanyl in Phacoemulsification	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-10-31	Hospital Oftalmológico de Brasília	Hospital Oftalmológico de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7c4c5jx	<NULL>	Patients undergoing phacoemulsification at HOBrasil, Salvador, Bahia; at least 18 years old; of both genders	Patients under 18 years of age; pregnant patients; patients with chronic pain syndrome; patients with hypersensitivity to any of the tested medications or the topical anesthesia used; patients with communication difficulties (significant hearing loss, speech impairments, aphasias); patients with physical status determined by the American Society of Anesthesiologists  classification of III-VI	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-7tpy7rr	Oropharyngeal exercises for Snoring and Sleep Apnea	Not yet recruiting	Intervention	2024-08-20	<NULL>	<NULL>	7236	Myofunctional Orofacial Therapy for the treatment of Primary Snoring and Obstructive Sleep Apnea: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-22	Departamento de Cirurgia da Universidade Federal do Rio Grande do Norte	Departamento de Cirurgia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7tpy7rr	<NULL>	Patients aged 18 year or older; diagnosis of obstructive sleep apnea or primary snoring by polysomnography.	Pregnancy; age below 18 years; psychiatric and cognitive disorders that impair understanding of the proposed therapy and providing consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-2dbpbjf	Comparative study of ways of positioning the head for computer planning of surgeries to correct facial deformities	Data analysis completed	Observational	2024-08-20	<NULL>	<NULL>	7237	Comparative study of head orientation methods using different software for virtual planning of orthognathic surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do RIo Grande do Norte	Universidade Federal do RIo Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2dbpbjf	<NULL>	Inclusion criteria were patients who were candidates for orthognathic surgery, including patients who underwent one- or multi-piece Le Fort one osteotomy, bilateral sagittal split osteotomy, and genioplasty, without significant asymmetries.	Exclusion criteria were patients undergoing temporomandibular joint (TMJ) reconstruction surgery, patients with TMJ pain, limited mouth opening and condylar resorptions, patients with any syndromic disorder, and patients with any lip and palate or facial cleft.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-2rhpn6x	Comparison between spinal morphine and nerve block for pain after ankle surgery: clinical study	Recruiting	Intervention	2024-08-20	<NULL>	<NULL>	7238	Evaluation of intrathecal morphine vs. sciatic and saphenous nerve block with or without adjuvants in postoperative analgesia for ankle fracture: a randomized clinical trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2024-07-08	Hospital Getúlio Vargas	Hospital Getúlio Vargas	https://ensaiosclinicos.gov.br/rg/RBR-2rhpn6x	<NULL>	Patients of both genders; who agree to participate in the study and sign the Free and Informed Consent Form ICF; aged eighteen years or older and younger than sixty five years; with a physical status classification of one to three according to the American Society of Anesthesiologists ASA; undergoing spinal anesthesia for ankle level surgeries	Refusal to participate in the research; difficulty in understanding the visual analog scale for pain; chronic use of analgesics and or contraindication to the use of nonsteroidal anti inflammatory drugs NSAIDs; body weight less than fifty kilograms to avoid toxic doses of local anesthetics; pregnant women; patients known to be allergic to local anesthetics and analgesics; those with an infection at the needle insertion site; coagulopathy; presence of neuropathy or neurological dysfunction in the lower extremities; and technical difficulties that do not allow for a block considered satisfactory by the technique described in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-8hzf6ns	Assessment of chewing of complete dentures fixed by one or two implants	Recruiting	Intervention	2024-08-20	<NULL>	<NULL>	7239	Clinical evaluation of masticatory efficiency of mandibular complete dentures converted into Overdentures with one or two implants: randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-03	Centro Universitário do Maranhão - UNICEUMA	Centro Universitário do Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-8hzf6ns	<NULL>	Adult patients; wearing well-adapted upper and lower complete dentures; free from injuries or pathological processes in the oral tissues; with stable health status ASA I or ASA II	Smoking patients; with uncontrolled systemic changes; insufficient rim; wearers of poor quality prostheses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-39gws45	Anxiety control in dental surgery	Recruiting	Intervention	2024-08-20	<NULL>	<NULL>	7240	The efficacy of Alprazolam for Anxiety control in third molar extractions	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-39gws45	<NULL>	Healthy volunteers; both genders; aged between 18 and 40 years; requiring extraction of retained third molars in similar positions regarding the type of impaction	Patients under 18 years old or over 40 years old; patients with body weight below 50kg or above 90kg; patients who have used anti-inflammatory or analgesic drugs up to 1 week before the first dental intervention; patients with a history of contraindication to the use of benzodiazepines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-9qtpxqt	Study on the effects of Acupuncture for women in Menopause	Recruiting	Intervention	2024-08-20	<NULL>	<NULL>	7241	Effects of Acupuncture on climacteric syndrome a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-9qtpxqt	<NULL>	Women aged between 40 and 60 years; presence of symptoms suggestive of climacteric syndrome such as hot flashes, night sweats, menstrual irregularities, mood swings, sleep disorders, reduced libido; agreement to voluntarily participate in the research after receiving detailed information and signing the Free and Informed Consent Form; availability to participate in acupuncture sessions; comply with the proposed assessments; not using hormone therapy in the last 6 months	Pregnancy or suspected pregnancy during the study period; history of serious psychiatric disorders; presence of dermatological diseases in the area of ​​application of the needles; history of bleeding disorders; participation in other simultaneous clinical trials; use of hormonal therapy in the last 6 months; other interventions for climacteric syndrome during the study period; extreme aversion to needles or previous adverse events related to this practice; diagnosis or suspicion of Cancer. Autoimmune diseases. Endocrinopathy (except controlled diabetes mellitus). Severe heart disease and uncontrolled arterial hypertension. Total hysterectomy or bilateral oophorectomy; performance of acupuncture in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-4cj96jy	The benefits of Physical Training for the autonomic nervous system and cognition in women who are Breast Cancer survivors	Recruitment completed	Observational	2024-08-20	<NULL>	<NULL>	7242	Autonomic dysfunction and cognitive loss in female Breast Cancer survivors. Impact of Physical Training	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-05	Universidade de São Paulo	Instituto do Câncer do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4cj96jy	<NULL>	Group 1 women; aged between 35 and 75 years; survivors of histologically proven invasive breast cancer; who completed treatment with curative intent including systemic chemotherapy; having completed treatment within a time interval of at least six months to four years; practicing physical exercises for at least 6 months as defined by the application of the international physical activity questionnaire (IPAQ); Group 2 women; aged between 35 and 75 years; survivors of histologically proven invasive breast cancer; who completed treatment with curative intent including systemic chemotherapy following the recommended guidelines; having completed treatment within a time interval of at least six months to four years; without regular practice of physical exercises in the last 6 months as defined by the application of the International international physical activity questionnaire (IPAQ); Group 3 women; aged 35-75 years; without a diagnosis of cancer; non-practitioners of systematic physical exercise on a regular basis in the last 6 months as defined by the application of the international physical activity questionnaire (IPAQ)	Group 1: evidence of metastatic disease (clinical and/or radiological) and/or conditions that prevent them from practicing physical exercise; severe organic dysfunctions (including, but not limited to, kidney failure, heart failure and chronic liver disease); previous cognitive dysfunction and (or) dysautonomia; presence of any medical contraindication to physical exercise; not being involved in any systematic exercise practice on a regular basis in the last 6 months.Group 2: evidence of metastatic disease (clinical and/or radiological) and/or conditions that prevent them from practicing physical exercise; severe organic dysfunctions (including, but not limited to, kidney failure, heart failure and chronic liver disease); previous cognitive dysfunction and (or) dysautonomia; presence of any medical contraindication to physical exercise; being involved in some systematic exercise practice on a regular basis in the last 6 months. Group 3: history of cancer treatment; presence of autonomic dysfunctions, cardiovascular problems, diagnosis of neurological diseases with cognitive involvement and presence of conditions that prevent them from practicing physical exercise; report of practicing systematic physical exercises, regularly, in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-99qvrnj	Assessment of postoperative events after Ozonetherapy in lower third molar Extractions	Not yet recruiting	Intervention	2024-08-19	<NULL>	<NULL>	7231	Effects of Ozonetherapy in the postoperative period of lower third molar Extraction – pilot, randomized, blind, split-mouth clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-20	Instituto de Ciência e Tecnologia - Campus de São José dos Campos – Universidade Estadual Paulista	Instituto de Ciência e Tecnologia - Campus de São José dos Campos – Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-99qvrnj	<NULL>	Female and male patients,  need of third molar extraction; regardless of gender; patients who have not used analgesics or anti-inflammatories in the last 15 days; have teeth in opposing semi-included or included hemi-arches, meeting the same classification as Pell &amp; Gregory (1933); aged between 18 and 30 years; who agree to participate in the research voluntarily, being aware of the risks and benefits, and sign the Free and Informed Consent Form (TCLE).	Patients who present local or systemic changes that contraindicate the procedure; patients undergoing drug treatments that interfere with the methodology; erupted lower third molars; patients allergic to anesthetics and medications; patients with contraindications to the use of ozone therapy; smoking patients; pregnant or lactating patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-106hchyb	Immediate effects of Mechanical Knee Traction with different weights on measures of Pain and Functional Capacity in people with Knee Osteoarthritis: a randomized clinical study	Not yet recruiting	Intervention	2024-08-19	<NULL>	<NULL>	7232	Immediate effects of Mechanical Femorotibial Traction with different loads on Pain and Functional Mobility measures in people with Knee Osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-30	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-106hchyb	<NULL>	Volunteers diagnosed with knee osteoarthritis; both genders; age over 40 years; feel pain in the knee with osteoarthritis; be able to walk without the aid of canes or walkers; be able to bend the knee up to 60º	Volunteers who underwent analgesic procedures 24 hours before the research; having undergone knee surgery in the last 12 months; present systemic inflammatory disease; to have a tumor in the knee; express skin diseases and/or open wounds around the knee joint; to have pain in the lower extremities related to: central nervous system disease; fibromyalgia; polyneuropathy; restless legs syndrome; hip diseases; compression of nerve roots	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-625yq2v	Impact of a Mindfulness-Based Intervention on the mental health of medical students	Recruitment completed	Intervention	2024-08-19	<NULL>	<NULL>	7233	Impact of a Mindfulness-Based Intervention on the mental health of medical students: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Cesumar - UniCesumar	Universidade Cesumar - UniCesumar	https://ensaiosclinicos.gov.br/rg/RBR-625yq2v	<NULL>	UniCesumar undergraduate medical students; aged 18 years or older; both genders; who wish to participate in the study; who can participate in at least three to four sessions of the mindfulness program; and provide informed consent	Students who report prior experience with mindfulness and other meditative practices in the last 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-6kynrxr	Hip muscle balance in women treated with dynamic insoles	Recruiting	Intervention	2024-08-19	<NULL>	<NULL>	7234	Analysis of hip muscle balance in women treated with dynamic insoles. A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Faculdade de Ciências Médicas Dr. José Antônio Garcia Coutinho	Faculdade de Ciências Médicas Dr. José Antônio Garcia Coutinho	https://ensaiosclinicos.gov.br/rg/RBR-6kynrxr	<NULL>	Women; aged between 18 and 40 years old; who presents dynamic knee valgus; whether or not they practice physical activity; who has not received any type of intervention for this dysfunction; who has medical clearance to perform the intervention	Women who do not present dynamic valgus; cognitive difficulties regarding assessment and intervention instruments; infectious diseases; disabling diseases in upper and lower limbs; dermatological lesions such as ulcers and blisters on the feet; patients with myopathies; diseases with recognized collagen alteration; people with neurological diseases; for personal reasons do not want to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-7sf8tq5	Effects of manual therapy associated or not with cervical manual therapy in pain, mouth opening and function in patients with temporomandibular disorder (TMD)	Recruitment completed	Intervention	2024-08-19	<NULL>	<NULL>	7235	Short-term effects of orofacial manual therapy associated or not with cervical manual therapy in pain, maximum mouth opening (MMO) and function in patients with temporomandibular disorder (TMD)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-29	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7sf8tq5	<NULL>	Age 18 to 60 years; Reside in the city of Porto Alegre; Signs and symptoms of TMD, with muscular characteristics, for at least three months, with a diagnosis of orofacial pain according to the DC/TMD classification; People with internet access; Responded to the CF-PDI through an online form; Read and consent to the Free and Informed Consent Form and understood the necessary guidelines for carrying out the evaluations proposed in this research.	Be undergoing physiotherapeutic treatment for the head and neck, diagnosis of fibromyalgia, history of trauma or surgery to the head and neck and recent dental prosthesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-5j2cd8q	Aquatic exercise and multimorbidity: Analysis of mental health parameters, cognition, functional autonomy, muscular efficiency and oxidative dysfunction induced by different HIIT models in the elderly	Recruiting	Intervention	2024-08-17	<NULL>	<NULL>	7230	HIIT in elderly people with multimorbidity: effects on psychophysiological health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-10	Universidade do Extremo Sul Catarinense - UNESC	Universidade do Extremo Sul Catarinense - UNESC	https://ensaiosclinicos.gov.br/rg/RBR-5j2cd8q	<NULL>	1) be over 60 years of age; 2) present a medical certificate showing the three associated multimorbidities (hypertension, diabetes and depression); 3) present a medical certificate authorizing aquatic physical exercise; 4) both genders	1) have any clinical impediment to physical exercise certified by a doctor; 2) have any other type of pathology, associated or not, that could interfere with the results of the study; 3) not present the documents requested; 4) not be over 60 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-6t3w7pt	Evaluation of a universal adhesive containing quercetin in non-carious cervical lesion restorations: a clinical trial.	Not yet recruiting	Intervention	2024-08-16	<NULL>	<NULL>	7228	Evaluation of the clinical longevity of a universal adhesive system containing nanoencapsulated quercetin in self-etch mode in non-carious cervical lesion restorations: a double-blind randomized clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-06	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6t3w7pt	<NULL>	Participants with good general health; participants aged over 18 years to 60 years (men and women); acceptable level of oral hygiene; participants must present at least 20 teeth in occlusion; 20 teeth in function; no active clasps from removable partial dentures on the included teeth; the teeth should not be abutments for prostheses; absence of periodontal disease; no active carious lesions; no parafunctional habits; participants should have at least two non-carious cervical lesions (NCCLs) to be restored in different teeth; the lesions should be non-retentive; lesions deeper than 1 mm; lesions that involve both enamel and dentin of vital teeth; and the cavosurface margin should not involve more than 50% of the enamel	Participants with extremely poor oral hygiene; participants using orthodontic devices; participants with severe or chronic periodontitis; participants with parafunctional habits; participants with known allergies to resin-based materials or any other materials used in this study; pregnant women; breastfeeding women; participants on chronic use of anti-inflammatories, analgesics, and psychotropics; participants who have difficulty attending follow-up appointments after the restoration will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-4j2g5qj	Effect of cardiac physiotherapy on the quality of life and frailty profile of women with breast cancer undergoing chemotherapy	Terminated	Intervention	2024-08-16	<NULL>	<NULL>	7229	Effect of cardiac rehabilitation on the quality of life and frailty profile of breast cancer patients undergoing chemotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-31	Universidade do Planalto Catarinense	Instituto do Coração de Lages	https://ensaiosclinicos.gov.br/rg/RBR-4j2g5qj	<NULL>	Women over 18 years old diagnosed with breast cancer, ductal carcinoma in situ or stages I to III, undergoing chemotherapy treatment. Agree to participate in the study by signing the free and informed consent form	Patients with self-reported physical or mental inability (assessed by the Mini-mental State) to perform the proposed exercises. Unavailability to participate in all stages of the research. Do not attend 75% of the proposed exercise program. Have had unstable angina or acute myocardial infarction in the last 30 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-46gs8pk	How the COVID-19 Pandemic Impacted Tuberculosis Control in São Paulo Challenges Realities and Solutions Technologies	Not yet recruiting	Intervention	2024-08-15	<NULL>	<NULL>	7220	Interaction and effect of the COVID-19 pandemic on tuberculosis control in the state of São Paulo: political-social, clinical-epidemiological aspects and innovative practices	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-08-20	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-46gs8pk	<NULL>	Managers from different levels (federal, state, regional, and municipal) will be included. Health and social assistance professionals who have worked in healthcare and/or health surveillance for at least six months, starting from September 2019, due to their prior experience before the pandemic context. Representatives of social movements and health councils (national, state, municipal, and local) who have at least six months of experience will also be interviewed. All cases and deaths from tuberculosis (TB) reported in the Notifiable Diseases Information System (SINAN) from 2015 to 2022 and cases and deaths from COVID-19 from 2020 to 2022 available on the Coronavirus Panel will be considered. The population for this study phase will consist of people undergoing treatment for TB. No gender criteria apply. Professionals who are part of the health team responsible for Directly Observed Treatment (DOT). Managers of the units (Primary Health Care (PHC) coordinators and/or coordinators of PHC units in the municipalities and units previously selected)	Serão excluídos gestores ou profissionais que não respondam a três contatos seguidos. Só serão considerados os casos e óbitos notificados como causa básica tuberculose ou COVID-19 dentro do período citado; outras doenças ou notificações fora do período serão excluídas. Serão excluídas pessoas que não estejam fazendo tratamento para tuberculose (TB) no momento e profissionais de saúde que não atuem no Tratamento Diretamente Observado (TDO), exceto gestores das unidades	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-3zjz5qd	Osteopathy and Microcephaly	Recruitment completed	Intervention	2024-08-15	<NULL>	<NULL>	7222	Osteopathy in Children Under Five Years of Age With Microcephaly: Pragmatic Quasi-experimental Study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-21	Faculdade de Medicina de Jundiaí	Faculdade de Medicina de Jundiaí	https://ensaiosclinicos.gov.br/rg/RBR-3zjz5qd	<NULL>	Babies and Children aged between zero and 5 years old; both sexes; whose mothers were infected or exposed to the ZIKV virus, positive or not for Zika virus (RT-qPCr); belonging to the Zika Virus Cohort or Cohort nested at Faculdade de Medicina de Jundiaí (FMJ);  children regularly seen at the aforementioned outpatient clinic and by active search for cases in the records of the Faculdade de Medicina de Jundiaí (FMJ) Pediatrics Outpatient Clinic of babies; children with signs of microcephaly at the first pediatric consultation. Children who did not initially show signs of microcephaly were also part of the sample, as they could develop it later	Children who do not allow osteopathic evaluation; those who cannot be monitored during the proposed research period; those who, on consultation days, manifest infectious diseases or any other changes that do not allow them to be evaluated and treated by osteopathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-5zfkxdy	Evaluation study of a rapid test and treatments for Chagas disease in Bahia, Brazil	Not yet recruiting	Observational	2024-08-15	<NULL>	<NULL>	7223	Evaluation of the effectiveness of a rapid test and treatments for Chagas disease: Oxente Chagas Bahia Cohort	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-10-28	Centro de Pesquisas Gonçalo Moniz	Instituto Gonçalo Moniz	https://ensaiosclinicos.gov.br/rg/RBR-5zfkxdy	<NULL>	Part A: Volunteers residing in the municipalities of Tremedal and Novo Horizonte, Bahia, with active registration in municipal health systems; both genders; and aged over nine months. Part B: Volunteers who tested positive with the Bio-Manguinhos Rapid Chagas Test, along with 10% of those who tested negative; both genders; and aged over nine months. Part C: Volunteers with laboratory-confirmed Chagas disease; both genders; aged under fifty years; and with a normal electrocardiogram (heart rate: 50-100 beats per minute, waves P and R (PR) interval ≤ 200 milliseconds, waves Q, R, and S (QRS) complex ≤ 120 milliseconds, and waves Q and T (QT) interval between 350-450 milliseconds)	Parts A and B: Volunteers residing in Novo Horizonte or Tremedal, Bahia, who are not registered with the local health systems will be excluded from the study, as will volunteers unable to undergo peripheral blood collection. Part C: Exclusion criteria include volunteers with signs of advanced chronic Chagas disease; diagnosis of HIV/AIDS, mental illness, or suicidal tendencies; any acute or chronic disease deemed contraindicated for treatment by the attending physician; history of alcoholism or drug use; known hypersensitivity to nitroimidazoles; and unavailability to comply with the procedures and visits outlined in the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-10ftp9pm	Effect of dietary changes for weight loss and fertility parameters in overweight and obese women	Recruiting	Intervention	2024-08-15	<NULL>	<NULL>	7224	Effect of nutritional intervention for weight loss and fertility indicators in Overweight and Obesity women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal de Goiás	Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-10ftp9pm	<NULL>	Women, aged between 20 and 40 years old; Body Mass Index (BMI) values between 25kg/m² and 34.9kg/m² who agree to participate in the work	Body Mass Index values &lt;25kg/m² and &gt;34.9kg/m²; diabetes mellitus (self-reported); elevated Follicle Stimulating Hormone levels (FSH &gt;9.9 nIU/mL), hypothyroidism and hyperthyroidism (TSH ≠ 0.4 to 5 mIU/L)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-9grvg8d	Evaluation of the cardiovascular effects of Medicinal Cannabis	Recruiting	Observational	2024-08-15	<NULL>	<NULL>	7225	Effects of Medicinal Cannabis on hemodynamics, on the nervous system autonomous and peripheral microcirculation of humans	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9grvg8d	<NULL>	adults of both sexes; older than 18 years old; be a patient at cannabis clinics medicine or the Basic Unit of Health; for the treatment group, carry out medical cannabis treatment on a continuous basis	patients with heart failure; patients with valvular heart disease; patients with infectious endocarditis; patients with peripheral arterial disease serious; patients on hemodialysis with fistula arteriovenous; patients with cardiac arrhythmias; patients with coronary disease ischemic (history of Acute Myocardial Infarction AMI) Systemic sclerosis; any decompensated chronic disease;history of syncope and collapse; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-105rqvph	Study to assess the quality of restorations made with composite resin and a polyethylene strip in posterior baby teeth: research with controlled trials	Not yet recruiting	Intervention	2024-08-15	<NULL>	<NULL>	7226	Clinical evaluation of the quality of direct class II restorations with composite resin associated with ribbond in primary molars: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-105rqvph	<NULL>	Children aged five to ten years old will be included; of both sexes; who may or may not have experience in dental care; and who need occlusoproximal restorative dental treatment in upper or lower deciduous molars due to caries lesions	Patients with acute pain or presence of odontogenic infection associated with systemic signs and symptoms; dental urgency; endodontic compromise; history of allergy to drugs used in the research or components of absolute isolation; history of asthma; extensive root resorption and neurological disorders will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-46ykd6t	Denture liner material with special antifungal medications in the treatment of Oral Candidiasis	Recruiting	Intervention	2024-08-14	<NULL>	<NULL>	7217	Tissue conditioner containing Nystatin Complexed with Beta-Cylodextrin for the treatment of denture stomatitis: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Unisagrado	https://ensaiosclinicos.gov.br/rg/RBR-46ykd6t	<NULL>	Volunteer users of conventional removable upper denture; clinical diagnosis for denture stomatitis in the palatal mucosa supporting the complete denture, both genders, any age, regardless of the condition of the mandibular arch and the use and status of the lower denture.	Volunteers with anemia; immunocompromised; with uncontrolled endocrinopathologies; in a therapeutic regimen with antibiotics, steroids or antifungals in the last three months; under antineoplastic treatment by radio or chemotherapy; users of the same upper complete denture for over 30 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-6bg2wmg	The effect of applying MESNA  medication to the ear in patients with Cholesteatoma	Recruitment completed	Intervention	2024-08-14	<NULL>	<NULL>	7218	Clinical efficacy of outpatient MESNA application in the control of acquired Cholesteatoma	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2022-10-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6bg2wmg	<NULL>	Patients over 18 years; middle ear cholesteatoma diagnosed; canal wall down mastoidectomy performed at least 6 months before inclusion in the study by the same three otologic surgeons at Escola Paulista de Medicina da Universidade Federal de São Paulo; chronic otorrhea (≥ 3 months) with purulent drainage refractory to medical treatment; audiometry test conducted in the postoperative period and within 6 months before inclusion in the study; patent meatoplasty allowing complete visualization of the surgical cavity	Use of systemic antibiotics and/or topical antibiotics, steroids or antifungals within 30 days prior to inclusion in the study; fever or perichondritis at the time of the study; allergy or hypersensitivity to sodium 2-mercaptoethanesulfonate (MESNA) or compounds containing the thiol group; malformation of the external auditory meatus or stenosis of the meatoplasty preventing appropriate visualization of the open mastoid cavity; fungal infection in the cavity identified by otoscopy; peripheral facial palsy; dehiscence of semicircular canal or facial nerve canal observed on temporal bone computed tomography or during mastoidectomy; profound sensorineural hearing loss in the ear opposite to the one included in the study; history of psychiatric illness; pregnancy; desire to become pregnant or breastfeeding during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-686kqdx	Chronic Effect of Time Under Stress in Recreational Runners	Not yet recruiting	Intervention	2024-08-14	<NULL>	<NULL>	7219	Chronic Effect of Strength Training with Time Under Tension on the Performance of Recreational Runners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-11	Universidade Federal de Sergipe - UFS	Universidade Federal de Sergipe - UFS	https://ensaiosclinicos.gov.br/rg/RBR-686kqdx	<NULL>	Volunteer for research; be 18 years of age or older; run at least three times a week with an average weekly mileage of 16 kilometers; have an average running pace of between 5 and 5:30 minutes per kilometer over a long distance; participate in a strength training program at least once a week with at least three months of practice, report no osteoarticular injuries during the last three months that compromised strength exercises and running; and have at least one year&apos;s experience in long-distance running	Individuals who do not perform all steps as instructed; present depravity in the upper respiratory tract; injuries that make it impossible to perform maximum effort during the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-7k3nv44	In search of protective correlation factors for dengue: Comparison of the effects caused by Dengue virus infection with the effects of the QDenga vaccine in different age groups	Recruitment completed	Intervention	2024-08-13	<NULL>	<NULL>	7209	In search of protection correlations for Dengue (Dengue Protect study): Comparison of the effects from Dengue infection with the effects from the inoculation of Qdenga vaccine in different age groups	<NULL>	1-2, n/a, open	1-2	<NULL>	<NULL>	<NULL>	2023-11-14	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7k3nv44	<NULL>	Vaccination cohort: Participants between 18 to 90 years of age who agree to participate in the study. Absence of an acute clinical condition at the time of vaccination. Infected cohort: Participants under 18 yeas old. Participants with more than 5 days of symptoms. Participants who do not agree to sign the informed consent form. Participants who are not available to carry out the planned study visits	Vaccination cohort: Participants under 18 years old. Participants who are not available to carry out the planned visits of the study. Participants who do not agree to sign the informed consent form. Positive beta Human Chorionic Gonadotropin on the day of vaccination, in the case of women of reproductive potential. Participants who are pregnant or planning to become pregnant within the next 3 months after the last vaccine dose. Participants breastfeeding. Participant with a known or suspected immune system defect that may influence the immunological response to the vaccine, such as participants with congenital or acquired immunodeficiency, including human immunodeficientcy virus infection, post-organ transplant status or immunosuppressive therapy within 4 weeks prior to Visit 1. Therapy Immunosuppressive is defined as chronic administration of prednisone (more than 14 days) or equivalent more or equal than 2 miligramas por kilo por dia in the 4 weeks prior to study entry, radiotherapy or immunosuppressive cytotoxic drugs or monoclonal antibodies in the 3 previous years, topical and inhaled steroids are permitted. Infected cohort: Participants with more than 5 days of symptoms. Participants who do not agree to sign the Informed consent form. Participants who are not available to carry out the planned study visits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-9mtvmqj	Saliva proteins from pregnant women with and without Obesity and gum inflammation	Recruiting	Observational	2024-08-13	<NULL>	<NULL>	7211	Salivary proteins of pregnant women with and without Obesity and Gingivitis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-15	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9mtvmqj	<NULL>	Pregnant women in the 3rd trimester of pregnancy; between 18 and 40 years of age; regular follow-up with the obstetrician; and who present adequate cognitive and neuromotor behavior; adequate ability to perform regular oral hygiene	Periodontitis; systemic arterial hypertension diagnosed before or during pregnancy; pre eclampsia; Gestational Diabetes Mellitus; Pre-pregnancy BMI lower than 18.5 kg/m2; Pre-pregnancy BMI between 25–29.99 kg/m2; diagnosed or suspected of being infected with SARS-CoV-2; absolute rest required; any other systemic disease; current use or use during pregnancy of antibiotics or any medication that harm periodontal condition and salivary flow; hyposalivation; consumption of any food or drink one hour or less before saliva collection; one or more cavitated carious lesions; multiple tooth loss; tooth loss prior to pregnancy due to periodontitis;  undergoing orthodontic, periodontal or any dental treatment with another dentist; previous surgical periodontal treatment; use of alcohol/tobacco/illegal drugs during pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-4hq4kd8	The effect of Stannous Fluoride Toothpaste in the treatment of Experimental Peri-implant Mucositis and Gingivitis: a randomized, double-blind, parallel-arm clinical trial	Recruiting	Intervention	2024-08-13	<NULL>	<NULL>	7212	The adjunctive Effect of Stannous Fluoride Toothpaste in the treatment of Experimental Peri-implant Mucositis and Gingivitis: a randomized, double-blind, parallel-arm clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-05-01	Faculdade de Odontologia da Universidade de São Paulo (FOUSP)	Faculdade de Odontologia da Universidade de São Paulo (FOUSP)	https://ensaiosclinicos.gov.br/rg/RBR-4hq4kd8	<NULL>	Volunteers with a minimum age of 18 years; with implant-supported single-unit screw-retained crown in the molar or premolar region with more than one year in function; with one molar or premolar tooth in the same arch as the implant; with a minimum of 20 teeth in function; periodontally healthy; with absence of infection, radiographic bone loss, and probing depth less than 4 mm at periodontal sites or less than or equal to 5 mm at peri-implant sites; with presence of at least 2 mm of peri-implant keratinized tissue; with full-mouth bleeding scores and full-mouth plaque scores less than or equal to 20%	Volunteers using antibiotics in the last 3 months; with implant insertion depth more than or equal to 3 mm; with diseases or systemic conditions that require the use of systemic anti-inflammatory drugs, antibiotics, anticoagulants, and others; smokers; diabetics; with an allergy to toothpaste or mouthwashes; pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-10ths4s7	Open, randomized clinical trial: the efficacy of mindfulness intervention on the mental well-being of patients had COVID-19	Data analysis completed	Intervention	2024-08-13	<NULL>	<NULL>	7213	Open, randomized clinical trial: the efficacy of mindfulness intervention on the mental well-being of post-COVID 19 patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-27	Instituto Nacional de Infectologia Evandro Chagas - INI / FIOCRUZ	Instituto Nacional de Infectologia Evandro Chagas - INI / FIOCRUZ	https://ensaiosclinicos.gov.br/rg/RBR-10ths4s7	<NULL>	Over 18 years old and of both sexes; Provide signed free and informed consent for yourself if legally capable, or by your legal representatives for those who do not have legal capacity; Agree to participate in all study visits, procedures and contacts; Post-COVID-19 symptoms (14 days to 12 months from the date of onset of symptoms, with positive antigen PCR or RT-PCR naso/oropharyngeal swab) directly related to Mental Health	Patients with hearing restrictions, with technological restrictions and without post-COVID-19 sequelae	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-3t2rmfs	Evaluation of different anesthetic techniques during the aesthetic application of botulinum toxin in the upper third of the face: randomized clinical trial	Data analysis completed	Intervention	2024-08-13	<NULL>	<NULL>	7214	Evaluation of different Anesthetic Techniques in Orofacial harmonization procedures: randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-01-06	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3t2rmfs	<NULL>	Female patients, aged over 18 years, systemically healthy, with no previous history of botulinum toxin application in the upper third of the face and who presented dynamic wrinkles in the upper third of the face.	Patients with abusive use of alcohol or illicit drugs, moderate smokers (&gt; 10 cigarettes/day), history of facial surgery, pregnant or breastfeeding, pre-existing disorders that affect neuromuscular function (such as myasthenia gravis, motor neurone disease), infections locals, undergoing remote or recent (&lt; 2 years) laser, radiotherapy or chemotherapy treatment in the orofacial region, who continuously take medications that may affect the metabolism of inflammatory mediators, and who are hypersensitive or allergic to botulinum toxin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:59
RBR-8c62pnj	Transcranial direct current stimulation on Pain, Disability and Quality of life in individuals with Low back pain	Terminated	Intervention	2024-08-13	<NULL>	<NULL>	7215	Transcranial direct current stimulation on Pain, Disability and Quality of life in individuals with Chronic non-specific low back pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-08	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8c62pnj	<NULL>	Age between 18 and 60 years; having non-specific chronic low back pain; having an average pain score greater than or equal to 4/10 on a numeric rating scale	Have specific spinal pathology (tumor, spondylolisthesis, fracture, herniated disc, etc.); nerve root pain; coexistence of major muscular, joint, neurological, or psychiatric conditions; having undergone back surgery; perform some treatment for non-specific chronic low back pain concomitantly with the study; making chronic use of analgesic opioids; present contraindications for tDCS; diabetes mellitus; uncontrolled hypertension; severe cardiovascular and/or pulmonary disease; pregnancy; malignant tumors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-49dt8yj	Use of technologies to monitor and guarantee the treatment of Tuberculosis among Migrants, Refugees and Stateless Persons in Brazil (MIRA-TB Project)	Not yet recruiting	Intervention	2024-08-13	<NULL>	<NULL>	7216	Implementation of technologies for tracking and adherence to treatment of Tuberculosis infection or disease among International Migrants, Refugees and Stateless Persons in Brazil (MIRA-TB Project)	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-08-20	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-49dt8yj	<NULL>	Individuals over 18 years old; both gender; international migrants, refugees, and stateless persons diagnosed through the verification of induration (greater than 5 mm) 72 hours after the application of the Tuberculin Test (TT), applied intradermally on the forearm and/or use of the Interferon-Gamma Release Assay (IGRA) in situations where the use of TT is not possible, and according to the protocols of the World Health Organization (WHO); migrants, refugees, and stateless persons with drug-resistant tuberculosis (DR-TB) identified through project screening and/or spontaneous demand at health services, diagnosed according to the protocols of the Ministry of Health (MoH), based on the Rapid Molecular Test (RMT), sputum smear microscopy, or sputum cultur	Lack of familiarity or difficulty using a smartphone; individuals under 18 years old; Brazilians; migrants, refugees, and stateless persons not residing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-9pb4qsq	Impact of COVID-19 on tuberculosis prevention and control in Brazil: a look at social policies, the disease situation and new technologies (CoV-TB Project)	Not yet recruiting	Intervention	2024-08-12	<NULL>	<NULL>	7205	Impact of COVID-19 on the prevention and control of Tuberculosis in Brazil: Analysis of social protection policies, the epidemiological situation and technological incorporation (CoV-TB Project)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-15	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9pb4qsq	<NULL>	New cases of tuberculosis. Over 18 years old. No gender criteria. Own a mobile phone (intervention group). Health professionals responsible for Directly Observed Treatment (DOT) and/or monitoring of people with tuberculosis. Unit managers (Primary Health Care (PHC) coordinators and/or tuberculosis program coordinators of the health units in the municipalities, previously selected)	Resistant Tuberculosis. Professionals and/or managers who have been in the position or working with tuberculosis for less than 6 months. Unavailability of individual or family cell phone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-7yt65zp	Effect of combining non-invasive brain stimulation of the cerebellum with balance training on improving stability in people with Parkinson&apos;s disease	Recruiting	Intervention	2024-08-12	<NULL>	<NULL>	7206	Effects of multiple sessions of transcranial direct current cerebellar stimulation during dynamic balance training on gains of balance stability in people with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Escola de Educação Física e Esportes da Universidade de São Paulo	Escola de Educação Física e Esportes da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7yt65zp	<NULL>	stages 2 and 3 on the Hoehn and Yahr scale; score ≥ 1 in the posture item of the Movement Disorders Society  Unified Parkinson’s Disease Rating Scale motor subscale; absence of neural implants, absence of neuro-osteomuscular and cognitive dysfunctions, consumption of medications that may affect motor performance; age between 50 to 80 years	Failure to participate in all assessment and training activities; failure to perform the training assignment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-2mfbfvp	Treatment of Depression in the elderly with Transcranial Magnetic Stimulation	Recruiting	Intervention	2024-08-12	<NULL>	<NULL>	7207	Treatment of Depression in the elderly with repetitive Transcranial Magnetic Stimulation using the Theta Burst method: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-26	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2mfbfvp	<NULL>	Be over 60 years of age and have an initial Hamilton Scale (HDRS) score greater than 08.	Having other mental disorders (alcohol or drug addiction; psychotic disorders; dementia); presence of severe neurological or clinical diseases; presence of severe suicidal ideation, presence of psychotic symptoms, presence of severe depression characterized as HDRS greater than 28 points, with a CIRS score (Cumulative Illness Rating Scale) &gt; 7, characterizing a set of clinical morbidities that may impair adherence to the protocol of research and presence of (hypo)manic symptoms demonstrated with more than 8 points on the Young Mania Rating Scale and bipolar rapid cyclers. In addition, specific contraindications to the use of rTMS also resulted in exclusion, such as metal implants, epilepsy or electronics in the cephalic segment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-6r8qgjp	Community-based multicomponent intervention for preventing alcohol use among teenagers	Recruiting	Intervention	2024-08-10	<NULL>	<NULL>	7201	Reduction of alcohol use among teenagers through a community-based multicomponent intervention: an implementation research approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6r8qgjp	<NULL>	Youth aged 10-18; families with one adult  (no age limit) and one teenager aged 10-14 who wish to participate in the program; there is no gender criteria	Young people who are not in the target age group; adults who do not have teenage children or who do not live in the cities agreed for the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-107mtjc8	Physical training with and without combined mental exercises and its effect on gait and cognition in the elderly	Recruiting	Intervention	2024-08-10	<NULL>	<NULL>	7202	High-intensity training associated or not with dual-task exercises and its effect on gait and cognitive capacity in the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Secretaria Municipal de Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-107mtjc8	<NULL>	60 years of age or older; both genders; live in Porto Alegre; be available to participate in the program on the days and times established; be physically independent	To have physical limitations that make it impossible to perform the proposed exercises; having uncontrolled chronic diseases; disabling pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-9wkqh8x	Results of Preventive Physiotherapy carried out using a cell phone application on workers&apos; Self-Perception of Health: a randomized clinical trial	Not yet recruiting	Intervention	2024-08-10	<NULL>	<NULL>	7203	Effects of Preventive Physiotherapy mediated by Mobile Application on workers&apos; self-perceived health: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-9wkqh8x	<NULL>	Participant of both sexes; participating employee must be over 20 years old; spend more than/equal to 8 hours sitting per day; the participant must have a cell phone with the messaging application (WhatsApp) installed	Participants who are being treated for chronic illnesses; participants who are away from their work duties during the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-3t8pw38	Effect of Laser on maternal complications during the Postpartum period	Not yet recruiting	Intervention	2024-08-10	<NULL>	<NULL>	7204	Effect of Photobiomodulation therapy on complications maternal during the Postpartum	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-20	Universidade Federal de Alfenas- Campus Santa Clara	Universidade Federal de Alfenas- Campus Santa Clara	https://ensaiosclinicos.gov.br/rg/RBR-3t8pw38	<NULL>	Age over 18 years; primiparous or multiparous; women after vaginal delivery with grade two, three, or four perineal laceration; women after vaginal delivery with episiotomy; approximation of the edges of the lesion by means of suturing (healing by first intention); pain graded in at least two, by the numerical scale of pain; ability to understand	Refusal to receive the protocol; presence of systemic or lesion-site infectious process; Birth of twins; hemodynamic instability; postpartum complications (hemorrhages); Use of medicines for associated diseases; Smoker; Diabetes mellitus or diabetes Gestational; neurological diseases; cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-45hz53y	The acidity of in-office bleaching gels affects dental sensitivity and bleaching efficacy in patients undergoing orthodontic treatment: A randomized clinical trial	Not yet recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7193	Effect of the acidity of in-office bleaching gels on dental sensitivity and bleaching effectiveness in orthodontic patients: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Andres Felipe felipe Millan Cardenas	Centro Universitário de Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-45hz53y	<NULL>	volunteers over 18 years old; with devices metal and ceramic orthodontics; good general and oral health; caries-free teeth; without gingival recessions and periodontal disease in the anterior region; who agree with the term of free and informed consent (TCLE); has one of the canines with color A2 or darker according to the Vita Classical scale	Patients who report previous tooth sensitivity; who had already undergone bleaching previously; smokers; women who are pregnant or breastfeeding; who were making continuous use of medication such as analgesics or anti-inflammatories; patients who used prostheses or had restorations in the upper anterior teeth; with parafunction, gingival recession; endodontic treatment of anterior teeth; severe tooth discoloration (tetracycline staining or fluorosis) and visible cracks in teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-5xhygvd	Evaluation of the pattern of gut bacteria in patients with type 2 Diabetes Mellitus using the drug Semaglutide	Recruitment completed	Intervention	2024-08-09	<NULL>	<NULL>	7194	Evaluation of the gut microbiota in patients with type 2 Diabetes mellitus using Semaglutide	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-06	Universidade Estadual de Campinas	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-5xhygvd	<NULL>	Both sexes; aged between 18-60 years; individuals with type 2 Diabetes Mellitus or Pre-Diabetes; with glycated hemoglobin between 5,7% and 10%; body mass index (BMI) of 25-39.99 Kg/m²; not using medication for Diabetes or using only oral antidiabetics (metformin and/or sulfonylurea); and creatinine clearance above 30ml/min/1,73m²	Age outside the proposed range; pregnant women; smoking; patients with Type 1 Diabetes Mellitus; individuals with suspected or confirmed retinopathy; patients with chronic intestinal pathology; patients previously submitted to bariatric surgery or any surgery that results in any one of resection/injury of the nervous plexus/deviation of intestinal transit; patients with severe chronic kidney disease (creatinine clearance ≤ 30ml/min/1.73m²); patients with moderate-intense gastroesophageal reflux disease; patients with a history of recurrent pancreatitis (because of an unclear cause, or an identified and still present cause); individuals who are using insulin; individuals who used any type of antibiotic in the last 3 months; individuals who make continuous use of probiotic drugs or proton pump inhibitors (omeprazole, pantoprazole, lansoprazole, esomeprazole, etc.); individuals who have used GLP-1 analogue drugs in the last 3 months; individuals who have a significant psychiatric disorder that may be related to the incorrect use of the medication and interfere with the results (schizophrenia, bipolar disorder, alcoholism, use of illicit substances, etc)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-2t5hntp	Effects of Exercise on the Health of Hemodialysis Patients	Recruitment completed	Intervention	2024-08-09	<NULL>	<NULL>	7195	Effects of a Strength or Endurance Exercise Program on the Clinical Parameters of Hemodialysis Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-22	Universidade Federal do Maranhão	Hospital Universitário da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-2t5hntp	<NULL>	Voluntary and consented participation; being on hemodialysis for more than three months; not present physical and motor impairments that make it impossible to perform the exercise; not have any type of medical contraindication that would make the intervention unfeasible; adult men and women; age between 18 and 59 years old; without distinction of race or ethnicity; have authorization from the medical team at the health center responsible for the patient	Severe physical disability; osteoarticular complications that do not allow training to be carried out; recent history of acute myocardial infarction; failure to sign the agreement; severe cognitive impairment that prevents them from understanding instructions given and carrying them out safely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-83fs5dr	Comparison of Treatment Duration (12 or 24 hours) for Patients with Postpartum Pre-Eclampsia: a Randomized Clinical Study	Not yet recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7196	Comparison of Magnesium Sulfate regimen for 12 or 24 hours in Postpartum Women with Pre-Eclampsia: A Randomized Clinical Study	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-83fs5dr	<NULL>	Pregnant patients, diagnosed with pre-eclampsia, with indication for the use of magnesium sulfate due to maternal cause, as assessed by the care team; start using magnesium sulfate before delivery, with a schedule for maintaining the medication after delivery	"Patient unable to understand the informed consent form, due to cognitive incapacity, definitive or temporary, as a result of pre-eclampsia itself (suspected bleeding in the central nervous system) or due to a cause prior to pregnancy. Patients unable to read the informed consent form (because they are intubated or have clinical or imaging evidence of neurological involvement) will not be invited to participate in this study, as they are considered to be in a vulnerable situation that prevents their participation in this protocol; gestational age is less than 24 weeks;
diagnosis of fetal death before delivery (i.e., ultrasound diagnosis of absence of fetal heartbeat upon admission for delivery); presence of multiple pregnancy (more than one fetus); patient with antenatal diagnosis of fetal malformation incompatible with extrauterine life; indication for the use of magnesium sulfate was made exclusively for fetal neuroprotection due to the risk of premature birth, without any maternal clinical indication that would justify its use; magnesium sulfate treatment was suspended before delivery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-8stsfvp	Assessment of dental stabilizing devices at the dental trauma clinic: a clinical study within the unified health system	Data analysis completed	Observational	2024-08-09	<NULL>	<NULL>	7197	Evaluation of dental splints at the dental trauma clinic: a clinical study in the SUS environment	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-30	Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8stsfvp	<NULL>	Patient referred to the Dental Trauma Clinic at the Dental Hospital of the Federal University of Uberlândia; patient with permanent traumatized tooth; both gender;  patient with dental splint; patient aged 6 years and above	Patients with traumatized primary teeth; patients under 6 years old; patients who can not attend follow-ups	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:19
RBR-5syrc3r	Individuals with Periodontitis with or without Down Syndrome	Recruiting	Observational	2024-08-09	<NULL>	<NULL>	7198	Immunoinflammatory profile of individuals with Periodontitis with or without Down Syndrome	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-01-11	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-5syrc3r	<NULL>	Forty-five individuals will be recruited and allocated to one of three study groups, according to the inclusion criteria: group control (C): fifteen with systemically healthy individuals, without Down syndrome (DS) and who qualify in the following definition of periodontal and gingival health: no loss of clinical attachment, with probing depth of up to 3 mm, bleeding in less than 10% of sites, no radiographic bone loss and age between 19 and 35 years. Group P: fifteen systemically healthy individuals without DS; diagnosed with grade C, stage III or IV periodontitis and aged between 19 and 35 years. DS group: fifteen systemically healthy individuals, diagnosed with DS and periodontitis; as a manifestation of systemic diseases and aged between 19 and 35 years	Exclusion criteria will be: current or past smoking habit; pregnancy or breastfeeding; use of antibiotic or anti-inflammatory medication in the 6-month period prior to the study; previous periodontal treatment within 6 months before sample collection; diabetes or other systemic diseases that affect the immuno-inflammatory process	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-3fmc62z	Analysis of the incidence, severity and temporal evolution of motion sickness after using the Air Force Academy&apos;s T-2000, T-3000 and T-4000 flight simulators	Not yet recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7199	Analysis of the incidence, severity and temporal evolution of Simulator Sickness after exposure to the Air Force Academy T-2000, T-3000 and T-4000 flight trainers: An exploratory experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade da Força Aérea	Academia da Força Aérea	https://ensaiosclinicos.gov.br/rg/RBR-3fmc62z	<NULL>	Healthy volunteers; both genders; aviation cadets enrolled in the second or fourth year of the Air Force Academy&apos;s Aviation Officer Training Course. For the sample referring to second year cadets, it will be required to have successfully completed the Primary Flight Course on the Universal aircraft. For the sample referring to fourth year cadets, it will be required to have successfully completed the Basic Flight Course on the Tucano aircraft.	Be medically exempt from aerial activity or simulator training for any reason.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-9ykz7ws	Effects of physical exercise associated with motivational techniques in individuals with chronic respiratory disease	Recruiting	Intervention	2024-08-09	<NULL>	<NULL>	7784	Effects of a physical training program associated with behavior change strategies on motivation for physical exercise in individuals with COPD: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Departamento de Fisioterapia da Universidade Federal de São Carlos	Departamento de Fisioterapia da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9ykz7ws	<NULL>	Patients of both genders diagnosed with chronic obstructive pulmonary disease - COPD, with a relationship between forced expiratory volume in one second and forced vital capacity less than 0.70; being clinically stable in the last four weeks; under medical follow-up and drug treatment; absence of participation in physical training programs in the last six months; age equal or over fifty years old; functional participants however with exercise capacity assessed by the six minute step test and/or six-minute walk test with values ​​below eighty percent of predicted; without cognitive deficit assessed by the Mini Mental State Examination - MMSE questionnaire; without changes in balance assessed by the short physical performance battery and acceptance to participate in the study	Intentional tremor; treatment of malignant neoplasm; body mass index above thirty five; rheumatic, neuromuscular, orthopedic and visual problems that make it impossible to walk or go up and down steps; unstable cardiovascular and respiratory diseases; and conditions that prevent testing and withdrawal from participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-2n5b5y3	Comparison between Femoral Nerve Anesthesia and Adductor Canal Anesthesia in analgesia and mobility in patients undergoing Revision knee prosthesis surgery randomized controlled clinical trial	Data analysis completed	Intervention	2024-08-08	<NULL>	<NULL>	7189	Comparison between Femoral Nerve Block and Adductor Canal Block in analgesia and mobility in patients undergoing Revision total knee Arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-25	Ministério da Saúde	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-2n5b5y3	<NULL>	Patients undergoing total knee arthroplasty revision surgery; both sexes; older than 18 years; classified by the American Society of Anesthesiology (ASA) as physical status I to III	Patients with daily consumption of opioids and/or antidepressants; patients in whom it was necessary to perform general anesthesia; patients with neurological and muscular diseases; patients allergic to dipyrone, tramadol and local anesthetics; bedridden and amputated patients; and patients with grade III obesity (BMI &gt; 40)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-66fjrf2	Effect of an Educational Intervention for informal caregivers of elderly people with Dementia	Recruitment completed	Intervention	2024-08-08	<NULL>	<NULL>	7190	Effectiveness of an Educational Intervention for informal caregivers of elderly people with Dementia: quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Fauldade de Enfermagem da Universidade Federal de Mato Grosso	Fauldade de Enfermagem da Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-66fjrf2	<NULL>	Being 18 years of age or older; being the main caregiver of an elderly person with dementia; having access to a smartphone with internet and knowing how to use a messaging application	Have difficulty communicating, hearing and understanding the questions asked by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-6d43xbb	The impact of Diabetic Neuropathy on physical performance in elderly endividuals with Type 2 Diabetes: a double-blind clinical trial on Combined Training Program	Recruiting	Intervention	2024-08-08	<NULL>	<NULL>	7191	The impact of Diabetic Neuropathy on physical performance after a Concurrent Training Program in elderly individuals living with Type 2 Diabetes	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-02	Universidade São Judas Tadeu	Instituto de Ortopedia e Traumatologia do Hospital das Clínica da Faculdade de Medicina da Universidade São Paulo (IOT-HC/FMUSP)	https://ensaiosclinicos.gov.br/rg/RBR-6d43xbb	<NULL>	Elderly patients aged 60 to 79 years; both genders; diagnosed with type 2 diabetes mellitus for more than two years; on a stable dose of medication (oral antidiabetics, insulin, or a combination of both) for over a year; glycated hemoglobin between 6 and 9.0%; Montreal Cognitive Assessment (MoCA) score above 26; without musculoskeletal system impairment; pain; any type of disabling disease or previous surgeries that could hinder physical training; without inadequately treated and decompensated chronic non-communicable disease	Inability to undergo assessments and reassessments; having more than three absences during the training period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8494rf7	Effect of Pharmaceutical Care on patients with Chronic Pain	Recruiting	Intervention	2024-08-08	<NULL>	<NULL>	7192	Effect of Pharmaceutical Care on patients with Chronic Pain: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-25	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8494rf7	<NULL>	Patients previously diagnosed with rheumatoid arthritis and/or fibromyalgia, according to the diagnostic criteria of the American College of Rheumatology. Patients of both gender. Aged over 18 years. Who have been using pharmacotherapy prescribed for rheumatoid arthritis for at least 6 months, and/or pharmacotherapy prescribed for fibromyalgia for at least 1 month	Patients with severe psychiatric disorders; cancer; pregnant women; those participating in other clinical trials that have the same outcomes or interventions that may cause a risk of bias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-722vgv8	Comics for health education of schoolchildren	Not yet recruiting	Intervention	2024-08-08	<NULL>	<NULL>	8271	Construction and validation of a comic book for health education for schoolchildren	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2026-08-02	Programa de Pós-Graduação em Saúde Coletiva da Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-722vgv8	<NULL>	School children enrolled in the 2nd to 5th grade of elementary school; aged between 7 and 10 years old; both genders	School children who have any limitation that prevents participation in intervention activities; or any severe metabolic alteration that requires the use of medications or specific dietary treatment that alters metabolism. In the event of the development of any of the exclusion criteria during the study, the child will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-863c6dk	Analysis of injuries and physical conditioning in amateur athletes and development of a preventive protocol	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7181	Analysis of the prevalence of injuries and cardiorespiratory fitness in amateur athletes and development of a preventive protocol	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-14	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-863c6dk	<NULL>	Both sexes; aged over 13; literate; that practice beach tennis and/or football at least once a week; capable of carrying out the proposed exercises and who agree to participate in the research by signing the Informed Assent Form (TAE) for underage participants and also; signature of their legal guardians on the Free and Informed Consent Form (TCLE). For participants over 18 years of age, agreement and signature of the Free and Informed Consent Form (TCLE)	Lack of autonomy (permanent or temporary); underlying cardiovascular disease in the last 24 months; such as acute myocardial infarction; angina; stroke or heart failure; body mass index (BMI) &gt;39.9 kg/m²; proliferative diabetic retinopathy or have a health problem that makes them unable to continue carrying out the planned protocols or suggested intervention, interrupt the practice during the research or abandon the study for personal reasons	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-4z7fhwb	Deliberate practice as a teaching strategy for family members of children with special health needs	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7182	Rapid cycle deliberate practice as a training strategy for family children with special health needs to perform pediatric cardiopulmonary resuscitation: a randomized simulation based study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-16	Hospital de Clinicas de Porto Alegre	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4z7fhwb	<NULL>	Family members of children aged one year old to twelve years old classified as children with special health needs according to the children with special health care needs screener instrument; both genders; self-declared as literate and minimum age of 18 years	Family members under eighteen years of age; those who do not have Brazilian Portuguese as their mother tongue; those with a self-declared physical difficulty that prevents them from participating in the training; family members who accompany children with special health needs with tracheostomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-4xc76cr	Effects of a Mindfulness-based intervention on stress symptoms, depressive symptoms and quality of life in patients with Recurrent Pregnancy Loss	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7183	The importance of the Mindfulness technique in reducing depression, stress, improvement quality of life and inflammation in women who have experienced Recurrent Pregnancy Loss	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-07	Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4xc76cr	<NULL>	Women over 18 years old; women with at least 2 miscarriages (excluding ectopic or molar pregnancies) being followed up at the Recurrent Pregnancy Loss outpatient clinic at Hospital das Clínicas da Universidade Federal de Minas Gerais (HC-UFMG); possess an electronic device (cell phone, computer or tablet) with internet access	Chronic inflammatory and autoimmune diseases; insanity; smoking; inability to answer the questionnaires; do not have an electronic device (cell phone, computer or tablet) with internet access	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-9n2854x	Assessment of nails, skin and hair in menopausal women after use of oral collagen or placebo	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7184	Evaluation of nail physiology, dermal thickness and hair shaft thickness in postmenopausal women supplemented with hydrolyzed oral collagen: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9n2854x	<NULL>	Menopausal women; aged 55 to 70; living in the region of Botucatu; agreeing to participate in the study	Immunocompromised women or those using immunosuppressive drugs; diabetics; using anticoagulants or with coagulation disorders; using oral retinoids;  patients with kidney disease;  thyropathies and inflammatory and infectious diseases of the fingernails and current and previous clinical diagnosis or evidence of any medical condition that exposes the patient to increased risk; interferes with the safety or efficacy of the proposed treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-1085kmg5	Effect of Lavander on preoperative Anxiety and postoperative Pain: randomized clinical trial	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7186	Effect of Lavandula Angustifolia on preoperative Anxiety and postoperative Pain: randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-05-06	Hospital Universitário Onofre Lopes da Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-1085kmg5	<NULL>	Individuals of both genders; aged 18 and over; who will undergo elective surgical procedures in the field of otolaryngology	Presence of reported or confirmed dementia; patients on mechanical ventilation; tracheostomized patients; and previous skull base surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-75jyknx	Comparative study of the effect of Blood by-products and Tissue Grafts from the palate on the coverage of Exposed Roots in a single tooth	Recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7187	Comparative analysis of the efficacy of Blood Derivatives and Subepithelial Connective Tissue Grafting on Root Covering of single Gingival Recessions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-09	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-75jyknx	<NULL>	Patients at least 18 years old. Both genders. Must not have prior experience with procedures for root coverage. Diagnosed with type one (RT1) unitary gingival recession, measuring at least 1.5 mm in the presence of dentin hypersensitivity or 2 mm in its absence, with apical displacement of the gingival margin but no loss of interproximal bone tissue. Additionally, clinical detection of the cementoenamel junction on the mesial and distalsurfaces of upper or lower canines and/or premolars should not be possible. Absence of restorations or caries in the area to be treated. Healthy periodontium, characterized by probing bleeding &lt; 10%. Probing depth of 3 mm	Patients with systemic diseases that may interfere with healing or periodontal health (such as diabetes, hypertension, and blood disorders, among others). Users of anticoagulant or antiplatelet drugs. Users of orthodontic appliances. Users of fixed or removable prostheses involving the canines and/or premolar teeth with gingival recession were selected for the study. Smokers; pregnant or lactating individuals. Gingival recession defects associated with dental caries lesions. Teeth with evidence of pulp pathology, molars, or teeth with severe misalignment (rotation or extrusion). Cases that do not meet the aforementioned inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-66hpcw7	Can whole genome sequencing improve Tuberculosis care?	Not yet recruiting	Intervention	2024-08-07	<NULL>	<NULL>	7188	Evaluation of the implementation of whole genome sequencing for diagnosis, detection of resistance and choice of therapeutic regimen for Tuberculosis in clinical practice conditions	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-12-01	Instituto de Ciências Biomédicas da Universidade de São Paulo - ICB/USP	Instituto de Ciências Biomédicas da Universidade de São Paulo - ICB/USP	https://ensaiosclinicos.gov.br/rg/RBR-66hpcw7	<NULL>	Both sexes. Be a patient of at least one of the six medical centers participating in this study during the data collection period. Patients with treatment failure or relapse in whom antimicrobial resistance is suspected, but diagnostic resistance tests have not been performed or who have a negative result for rifampicin resistance on the Xpert® MTB/RIF Ultra. Patients with a positive test for rifampicin resistance by Xpert® MTB/RIF Ultra. Patients with a negative test for resistance to rifampicin by the Xpert® MTB/RIF Ultra, but positive for resistance to any of the first-line drugs by the Hain ribbon genotypic tests (GenoType MTBDR). Patients with relapse and previous diagnosis of resistant Tuberculosis	Extrapulmonary tuberculosis at the time of diagnosis or diagnosed during the study. Negative culture. Co-infection with nontuberculous mycobacteria. Patients who change treatment centers during the study. Patients who wish to abandon the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-84pqzdw	Stimulating movement and Physiotherapy interventions to prevent post-cesarean pain	Not yet recruiting	Intervention	2024-08-06	<NULL>	<NULL>	7177	Stimulation of movement and Physiotherapeutic interventions in the immediate postpartum of cesarean section to prevent pain due to antalgic postures: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Hospital das Clínicas da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-84pqzdw	<NULL>	Postpartum women undergoing cesarean section; over 15 years old; hemodynamically stable; conscious; oriented; in good clinical condition according to progress in the medical record; whose procedure was carried out more than eight hours ago; after having had the bladder catheter removed and who ate after surgery	Women who present complications/intercurrences; who have clinical contraindications or medical diagnosis of impaired cognition that makes participation impossible; as well as those who required the use of opioid medications before allocation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-37jy8dh	Effects of Auricular Branch Vagus Nerve Stimulation in elderly people with Mild Cognitive Impairment	Recruitment completed	Intervention	2024-08-06	<NULL>	<NULL>	7178	Effects of Auricular Branch Vagus Nerve Stimulation in elderly people with Mild Cognitive Impairment: A double-blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-37jy8dh	<NULL>	Individuals of both sexes; aged between 60 and 79 years old; diagnosed with Mild Cognitive Impairment (MCI); who present Montreal Cognitive Assessment (MoCA) with a score greater than 12, without a diagnosis of dementia and less than 26 points	Individuals with epilepsy; immunocompromised; with oncological and infectious pathologies; diagnosis of bipolarity; pacemaker holders; participants with wounds on the ear surface due to the application of electrodes to the area; symptoms of Covid-19 or testing positive for Covid-19 during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-88djbyd	Characterization of plant food compounds in breast milk	Recruitment completed	Observational	2024-08-06	<NULL>	<NULL>	7179	Characterization of phenolic compounds in human breast milk	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-88djbyd	<NULL>	Lactating women; primiparous and multiparous;  mothers of full-term or premature babies; aged between 18 and 40 years; Body Mass Index - BMI between 18.5kg/m2 and 39.9kg/m2; with single or multiple (twin) pregnancies; who are breastfeeding exclusively or partially	The use of medications or therapies that influence lactogenesis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-9rh56ph	Effects of Intermittent Fasting in individuals with obesity and Obstructive Sleep Apnea	Recruitment completed	Intervention	2024-08-06	<NULL>	<NULL>	7180	Effects of a nutritional intervention with Time Restricted Eating in individuals with Obstructive Sleep Apnea	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-25	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-9rh56ph	<NULL>	Adult individuals aged between 18 and 60 years; with a Body Mass Index (BMI) between 25 and 40 Kg/m²; diagnosed with sleep apnea obstructive by polysomnography and/or medical diagnosis made in the last 6 months; whether or not they are being treated with oxygen therapy such as Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (BiPAP); of both sexes; with a feeding window between 11 and 14 hours	Individuals who have a serious illness such as cancer, liver or kidney disease; pregnant women or those with children up to two years old; institutionalised elderly people; individuals who are engaged in some kind of weight loss treatment or nutritional monitoring; those taking medication that interferes with metabolic rate (appetite suppressants, thyroid hormones); people who have a physical or intellectual disability proven by a medical diagnosis; people who are unable to take part in the proposed assessments; people who refuse to take part in the proposed assessments or interventions; people who have other sleep disorders such as insomnia, restless legs syndrome, narcolepsy; shift or night workers; participants who do not adhere to the proposed treatment; people who do not complete the proposed assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-7xz8bvw	Comparison of the effect of Laser protocol and Cryotherapy on the occurrence of postoperative pain in inflamed molar teeth	Not yet recruiting	Intervention	2024-08-05	<NULL>	<NULL>	7176	Comparison of the effect of Photobiomodulation protocol and Cryotherapy on the occurrence of postoperative pain and on the success of endodontic treatment in molar teeth with Irreversible pulpitis. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-07	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-7xz8bvw	<NULL>	Capable adult patients; aged between 18 and 65 years; both genders; who already have an indication for endodontic treatment in permanent molar teeth; diagnosed with irreversible pulpitis, confirmed by a positive response to clinical, electrical sensitivity and radiographic tests; have a contact number (telephone or cell phone or username on social networks) to be able to carry out postoperative evaluations	Patients who are at any stage of pregnancy. Patients who have been taking any medication such as analgesics or anti-inflammatories in the last 48 hours or who are immunocompromised, as these factors may alter the perception of pain or interfere with the analysis of the post-treatment pain score. Patients who have teeth with endodontic complications, such as: calcifications, external or internal resorption, partial formation of the apex, with dental perforations, with longitudinal or vertical fractures or with severe periodontal disease. During the endodontic procedure, patients who cannot have the endodontic treatment completed in the same session, or those patients who for any reason cannot be contacted to perform the outcome assessment will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8mzx59w	Progressive resistance training program to improve muscle strength and mass and quality of life in patients with Chronic Respiratory Disease	Recruiting	Intervention	2024-08-02	<NULL>	<NULL>	7173	Progressive resistance training Program to improve functional capacity and quality of life in patients with Fibrosis Idiopathic Pulmonary	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-04	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Policlínica Piquet Carneiro	https://ensaiosclinicos.gov.br/rg/RBR-8mzx59w	<NULL>	Patients with an established diagnosis of Idiopathic Pulmonary Fibrosis according to the clinical practice guidelines of the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society and the Latin American Association 2018; of both genders; minimum age 60 years; clinical stability; absence of exacerbations or hospitalizations for the underlying disease for at least one month	Patients with any illness that prevents the examination from being carried out; cognitive changes; osteomioarticular blocks; cardiac arrhythmias; myocardial infarction less than three months ago; unstable angina; uncontrolled high blood pressure; patients who perform regular physical activity or who are participating in a physiotherapeutic program to treat Idiopatic Pulmonary FibrosisF; patients who are unable to perform the proposed exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8mk389h	Increase in short dental implant primary stability with Osseodensification: a split-mouth clinical study	Recruitment completed	Intervention	2024-08-02	<NULL>	<NULL>	7175	1-Year follow-up of clinical parameters and implant stability installed using Osseodensification	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8mk389h	<NULL>	Healthy participants of both sexes; at least 18 years old; that present at least 2 edentulous sites with a minimum bone height of 10 mm and a minimum cervical bone thickness of 5 mm; minimum age of 18 years; ASA I or ASA II patients - American Society of Anesthesiologists; healthy adjacent teeth or without the need for prosthetic restoration;  patients who have signed the Free and Informed Consent Form (TCLE)	History of alcoholism; smokers; illicit drug users; heart disease; decompensated diabetics; complex rehabilitation needs (change in the vertical dimension of occlusion, need for other rehabilitation procedures); lack of sufficient height and bone thickness; carriers of parafunctional habits (bruxism); grafted areas; irradiated patients; patients who have undergone long-term steroid treatment or bisphosphonate users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-2vmgq95	Cardiovascular effects of super short intense acceleration training in men with high blood pressure	Recruiting	Intervention	2024-08-01	<NULL>	<NULL>	7169	Cardiovascular effects of super sprints training shorts in men with arterial hypertension	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal de Mato Grosso do Sul - UFMS	Universidade Federal de Mato Grosso do Sul - UFMS	https://ensaiosclinicos.gov.br/rg/RBR-2vmgq95	<NULL>	Men. Age between thirty and sixty years. Previous medical diagnosis of primary hypertension or use of at least one antihypertensive medication. Stage one arterial hypertension diagnosed at least one year ago. If taking antihypertensive medication that has not changed for at least two months. Have not participated in regular exercise programs in the last three months prior to the study. Agree to sign the informed consent form. Volunteers without arterial hypertension must only meet the criteria for males. Age between thirty and sixty years. Abstained from regular exercise in the last three months. Agree to sign the informed consent form	Significant comorbidities such as heart failure; chronic obstructive pulmonary disease; changes in cognitive impairment or psychiatric illness; previous stroke; neuromuscular disease; asthma; uncontrolled diabetes; peripheral vascular disease; grade three obesity; renal failure; sleep apnea; malnutrition or other diseases that interfere with protocol performance; secondary hypertension; individuals with contraindications to performing a symptom-limited maximal exercise test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-10cc7t2f	Relationship between mouth and gut microbiomes in patients with periodontal diseases - cross-sectional study	Recruitment completed	Observational	2024-08-01	<NULL>	<NULL>	7170	Evaluation of the relationship between subgingival and intestinal microbiomes in patients with periodontal diseases - cross-sectional study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10cc7t2f	<NULL>	All individuals must be systemically healthy; of either gender; at least 18 years old; have at least 15 natural teeth, excluding third molars and teeth indicated for extraction; and be willing to adhere to the study protocol. In the Periodontal Health group: absence of attachment loss and bone loss due to periodontitis; probing depth (PD) up to 3 mm at all sites and bleeding on probing (BOP) at no more than 10% of sites throughout the entire oral cavity. For the Gingivitis group: presence of generalized gingivitis, with more than 30% of the sites in the whole mouth showing BOP; all sites with PD up to 3 mm and absence of attachment loss and bone loss due to periodontitis. In the Periodontitis group: presence of generalized stage III periodontitis, grades B or C, with at least 30% of the teeth having at least one site with PD and Clinical Attachment Level (CAL) ≥ 5 mm and BOP	Use of antibiotics, probiotics, and/or prebiotics in the last six months; undergoing periodontal treatment in the last six months; continuous use of mouthwashes containing antimicrobial agents; long-term use of anti-inflammatory or immunosuppressive medication; any systemic involvement that may interfere with the onset and/or progression of periodontal diseases; chronic gastrointestinal diseases; extensive prosthetic involvement; need for antibiotic prophylaxis for routine dental procedures; smoking; pregnancy; lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-5r6pm9x	Effects of Neuromodulation associated with Treadmill gait Training on functional mobility and balance in people with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2024-08-01	<NULL>	<NULL>	7171	Effects of repetitive Trans-spinal Magnetic Stimulation associated with Treadmill gait Training on functional mobility and postural balance in people with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5r6pm9x	<NULL>	Men and women between 18 and 80 years old; people with Parkinson&apos;s Disease (PD) in Hoehn Yahr stages between 2 and 4 (moderate disease) whose primary symptom includes gait alteration; being able to walk independently for 30 meters or with a unilateral assistive device; having a Mini-Mental State Examination (MMSE) score greater than or equal to 24 for people with more than 8 years of schooling and above 20 points for illiterate people	Unstabilized psychiatric comorbidities; other neurological disorders, musculoskeletal, orthopedic, cardiovascular, and respiratory changes that may affect the ability to walk on the treadmill; labyrinthine problems; deep brain stimulation surgery or epidural stimulation of the spinal cord; uncontrolled infection or other uncontrolled pre-existing medical conditions (e.g. uncontrolled infection or other uncontrolled pre-existing medical conditions (e.g. decompensated diabetes, hypertension, symptomatic lung or heart disease); concomitant treatment with other experimental drugs; pregnant or breastfeeding women; chronic low back and lower limb pain; not walking without an aid (cane, crutch, walker) or help from another person; metal implants and cardiac pacemakers; history of neurosurgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-648sztz	Auriculotherapy used to control anxiety	Recruitment completed	Intervention	2024-07-30	<NULL>	<NULL>	7166	Use of auriculotherapy to control anxiety in dental clinical practice	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Centro Universitário do Leste de Minas Gerais	Centro Universitário do Leste de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-648sztz	<NULL>	Individuals treated at the Dental School Clinic; of both sexes; aged over 18; no cognitive deficit; who agreed to participate in the study after reading and signing the Informed Consent Form	Individuals under 18 years of age; who do not wish to participate in the study; or present cognitive deficit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-4t4bcvy	Effect of Pre-treatment with Aluminum Oxide on dentin and adhesive strategies on the clinical performance of Restorations in Non-carious Cervical Lesions	Recruitment completed	Intervention	2024-07-30	<NULL>	<NULL>	7167	Effect of Air Abrasion Aluminum Oxide on dentin and Universal Adhesive System with different adhesive strategies on the clinical performance of Restorations in Ron-carious Cervical Lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-24	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4t4bcvy	<NULL>	Minimum age of 18 years;  both genders; good oral hygiene; at least 20 teeth in occlusion; at least four teeth with non-carious cervical lesionswith antagonists; non-carious cervical lesionswith antagonists with a depth of at least 1 mm (TWI index 3 and 4)	Severe periodontal disease; cavities; xerostomia; medical problems that prevent them from attending review appointments; active bruxism; endodontic treatment in the tooth with a non-carious cervical lesion; patients with orthodontic appliances; have had teeth whitening in the last 6 months; pregnancy and/or lactation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-1045xxpm	Effects of multidisciplinary educational intervention on the level of knowledge, quality of Life and self-care of elderly diabetics: a randomized clinical trial	Recruitment completed	Intervention	2024-07-30	<NULL>	<NULL>	7168	Effects of multidisciplinary educational intervention on the level of knowledge, quality of Life and self-care of elderly people with Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-02	Faculdade de Medicina de Marília (FAMEMA)	Faculdade de Medicina de Marília (FAMEMA)	https://ensaiosclinicos.gov.br/rg/RBR-1045xxpm	<NULL>	Have been diagnosed with Diabetes Mellitus for more than six months; be aged 60 or over; agree to participate in the study and sign the Consent Form	Cognitive and intellectual limitations that make it impossible to respond to the study instruments; being bedridden or unable to move around to participate in the study; unjustified absence in intervention activities; change of city, illness or death during the study; withdrawal from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-2rhxcc8	Effects of Weight Training and Running on Obese adolescents	Recruitment completed	Intervention	2024-07-29	<NULL>	<NULL>	7161	Effects of Strength and Competitive Training protocols on Metabolic Syndrome Indicators in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-01	Universidade José Rosário Vellano Unifenas	Universidade José Rosário Vellano Unifenas	https://ensaiosclinicos.gov.br/rg/RBR-2rhxcc8	<NULL>	Overweight or obese individuals; aged between 12 and 19 years; of both sexes; sedentary individuals; agreeing to take part in the study and signing an informed consent form; not undergoing any type of treatment for metabolic diseases or using drugs or procedures that could compromise the analysis; not having been diagnosed with thyroid or endocrine/genetic diseases	Individuals who have orthopedic and cardiovascular limitations to physical practice; individuals who exercise regularly; individuals who do not comply with the researcher&apos;s requests for prior collection procedures; individuals who miss the scheduled dates for blood collection and physical assessments; individuals who miss two consecutive weeks of training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-2f58ykv	Educational-care strategy for guidance on self-care, through a chatbot, for the Health Care Network and for people with intestinal stoma	Not yet recruiting	Intervention	2024-07-29	<NULL>	<NULL>	7162	Educational-care technological strategy for guidance on self-care, through a chatbot-type mobile application, to Health Care Network and for people with intestinal ostomies in State of Pernambuco	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-20	Fundação Universidade de Pernambuco	Complexo Hospitalar do Hospital Universitário Oswaldo Cruz/Pronto-Socorro Cardiológico Universitário de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2f58ykv	<NULL>	Age equal to or over 18 years old; have a colostomy or ileostomy; post-operative time from 1 to 4 months	Illiterate; psychiatric disorder; cognitive deficit; physical disability that compromises the practice of self-care; total or partial sensorimotor alteration; presence of peristomal dermatitis; presence of prolapse; presence of a hernia; presence of retraction; have received prior guidance on how to care for an intestinal ostomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-34h937k	General, systemic and cerebral ffects of Photobiomodulation	Data analysis completed	Observational	2024-07-29	<NULL>	<NULL>	7163	Systemic, integral and integrated effects in Transcranial Photobiomodulation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-10	Universidade Anhembi Morumbi	Universidade Anhembi Morumbi	https://ensaiosclinicos.gov.br/rg/RBR-34h937k	<NULL>	Healthy women; age between 18 and 60 years old; teachers, taking into account the complaint of vocal fatigue reported and identified in a previous vocal screening exam carried out by the author	Male teachers and those who were unable to perform the voice emission collection due to difficulties in understanding and/or inherent to the practice of the exam were exclude	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-9fbrcsy	Effect of laser therapy on healing and pain reduction after surgery for correction of gummy smile	Recruitment completed	Intervention	2024-07-29	<NULL>	<NULL>	7164	The efficacy of Low-level Laser Photobiomodulation in tissue healing and postoperative pain following Clinical Crown Lengthening surgery in esthetic areas: a split-mouth, triple-blind, randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-09	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	Departamento de Odontologia da Universidade Federal do Rio Grande do Norte - Lagoa Nova Campus Central	https://ensaiosclinicos.gov.br/rg/RBR-9fbrcsy	<NULL>	Individuals over 18 years old; gummy smile caused by altered passive eruption or by improper positioning of gingival zeniths in the anterior region of the maxilla or mandible; having at least six teeth affected by the gummy smile; probing bleeding index less than 10%	Individuals with indications for gingivectomy/plasty; etiologies of gingival alterations indicating this type of surgery; patients with drug-induced gingival enlargement; patients with aesthetic restorations; orthodontic appliance users; those presenting active periodontal disease; smokers; pregnant or lactating women; individuals allergic to the medications prescribed in the study; patients with systemic diseases that may interfere with healing or periodontal health (such as diabetes, blood dyscrasias, among others)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-7h672c9	Effect of Pilates on strength and movement in Crossfit practitioners	Data analysis completed	Intervention	2024-07-29	<NULL>	<NULL>	7165	Effect of Pilates on strength and range of movement in extreme conditioning practitioners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal do Triangulo Mineiro	Universidade federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7h672c9	<NULL>	Individuals of both sexes; Age 18 or over years; Healthy; Practicing extreme conditioning program (ECP) for at least month; Who are enrolled and present at these academies on the day of the assessment; Agree to participate in the research and sign the Informed Consent Form	Beginners who do not attend the reevaluation; Beginners who stop practicing the activity during the study; Volunteers who experience discomfort or restrictions when performing any of the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-8w4bjf8	Clinical trial of treatment with Transcranial Magnetic Stimulation (brain stimulation) in negative symptoms of Schizophrenia	Recruiting	Intervention	2024-07-26	<NULL>	<NULL>	7160	Randomized, double-blind, sham-controlled clinical trial, of Transcranial Magnetic Stimulation intervention with Theta Burst (iTBS) in negative symptoms of Schizophrenia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-15	Universidade Federal de São Paulo (UNIFESP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-8w4bjf8	<NULL>	Individuals diagnosed with Schizophrenia (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders - DSM 5); aged 18 to 50; both genders; presenting with moderate intensity negative symptoms; capable of reading and understanding Portuguese; with stable use of medications and no changes in antipsychotics in the last three months; not using anticonvulsant medications; not having abused drugs or alcohol in the past year; not having undergone any brain stimulation protocols in the past year before admission to the study	Individuals diagnosed with depression or substance abuse dependency, as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); diagnosed neurological disorders (epilepsy and history of seizures, traumatic brain injury); presence of metallic implants in the brain region (pacemakers, cochlear implants, implanted electrodes/stimulators, aneurysm clips/coils, stents)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-5rp37x8	Effect of Auricular acupuncture for nausea and vomiting in adult Cancer patients	Terminated	Intervention	2024-07-25	<NULL>	<NULL>	7159	Effect of Auriculotherapy on the control of chemotherapy-induced nausea and vomiting in adult cancer patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-06	Universidade Federal de Alfenas (UNIFAL-MG)	Universidade Federal de Alfenas (UNIFAL-MG)	https://ensaiosclinicos.gov.br/rg/RBR-5rp37x8	<NULL>	Age 18 or over, regardless of gender; have a confirmed diagnosis of cancer, of any histological type and staging of the disease; during the data collection of the study be undergoing chemotherapy for adjuvant, neoadjuvant or palliative purposes; report the presence of nausea and/or vomiting; have time available to participate in the auricular acupuncture sessions; have a performance status equal to or less than three according to the Eastern Cooperative Oncology Group Performance Status	Inflammations, infections, ulcerations or deformities of the ear; use of hearing aids; confirmed or suspected pregnancy; allergy to microporous tape	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-4h6h9fd	Analysis of Tooth Extraction Area Filled for Particulate Dentin or Blood Clot: A Randomized Split-Mouth Clinical Trial	Recruiting	Intervention	2024-07-24	<NULL>	<NULL>	7149	Analysis of Post-Extration Dental Alveoli Filled by Particulate Dentin or Blood Clots: A Ranzomized Split-Mouth Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4h6h9fd	<NULL>	Healthy patients; both genders; from 18 to 65 years old; indication of bilateral extraction of lower third molars; in accordance with the signing of the Free and Informed Consent Form; attended at the clinics of the Dentistry Course at the University of Passo Fundo and/or at the Centro de Estudos Odontológico Meridional	"Patients with serious comorbidities; users of alcohol, tobacco and/or illicit drugs; diseases or medications that affect bone metabolism; serial unilateral extractions; teeth with endodontic lesions,
deep caries, periodontitis or recurrent pericoronitis"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-8hcb95v	Effect of Coconut Oil on Vaginal Hydration after Exposure to Cancer Treatment	Data analysis completed	Intervention	2024-07-24	<NULL>	<NULL>	7150	Evaluation of the effect of coconut oil as a vaginal restructuring agent for patients undergoing chemotherapy and radiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-26	Centro Universitário CESMAC	Centro Universitário CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-8hcb95v	<NULL>	Women with a confirmed diagnosis of cancer (all types) undergoing chemotherapy or radiotherapy; between 18-50 years old; with an active sexual life; who agree to the Informed Consent Form of this research	Women with secondary amenorrhea or menopause will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-9x4nzb6	The impact of the adhesive strategy on the durability of restorations in teeth with MIH - a clinical study	Recruiting	Intervention	2024-07-24	<NULL>	<NULL>	7151	Impact of the adhesive strategy on the survival of molar restorations with MIH - randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-08	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9x4nzb6	<NULL>	Children with Incisor Molar Hypomineralization in the first permanent molars; with opacity and loss of tooth structure on two sides of the tooth; with or without sensitivity and with pulp vitality	Children who do not have Incisor Molar Hypomineralization; or that have this defect in permanent first molars but without loss of structure; or with the loss of only one face; teeth not fully erupted; and teeth without pulp vitality	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-6x32np2	Evaluation of the applicability of membranes of poly ɛ- caprolactone charged with drugs in the treatment of wounds	Data analysis completed	Intervention	2024-07-24	<NULL>	<NULL>	7152	Effectiveness of the controlled release of poly ɛ-caprolactone membranes obtained by electrospinning in treating complex wounds, free from infection, in patients with vascular diseases with or without surgical treatment: randomized, comparative study and control	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2019-07-26	Universidade Federal do Amazonas	Hospital Pronto Socorro 28 de Agosto	https://ensaiosclinicos.gov.br/rg/RBR-6x32np2	<NULL>	Patients aged 18 or older; legally responsible; presenting clean wounds in the granulation phase; admitted to the Emergency Hospital; assisted by the Hospital Infection Control Committee unit of the facility	Patients with the need of surgical treatment; those undergoing antibiotic therapy; presenting difficult-to-control hyperglycemia above 300 mm/dL; peripheral arterial obstructive disease; venous hypertension; chronic venous insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-2b9qf7h	Skeletal stability and accuracy of surgery protocols and orthodontic treatment using Clear Aligner in patients with Mandibular protrusion	Recruiting	Intervention	2024-07-24	<NULL>	<NULL>	7153	Three-dimensional skeletal stability and accuracy of Surgery-first protocols and orthodontic treatment using Clear Aligners	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2b9qf7h	<NULL>	Anteroposterior relationship between the maxillary and mandibular bone bases less than zero degrees; Wittes index negative; etiology related to mandibular excess, maxillary deficiency, or a combination of both; concave profile; presence of at least 3 stable occlusal contact points to ensure both surgical and postoperative stability; need for bimaxillary surgery with LeFort I osteotomy and bilateral sagittal osteotomy, and genioplasty; and absence of residual bone growth	History of maxillary bone surgery or facial trauma or bone pathologies; total edentulism; a pronounced curve of Spee of more than 3mm; use of any medication contraindicated for surgical treatment; joint or autoimmune syndromes and diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-7v2jnwr	Pharmacist&apos;s role in controlling glucose levels in patients using insulin in the Unified Health System	Recruitment completed	Intervention	2024-07-24	<NULL>	<NULL>	7155	Pharmaceutical care in glycemic control of insulin-dependent patients in Primary Health Care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-7v2jnwr	<NULL>	Patients with type 2 diabetes mellitus (DM2); who use Hagedorn&apos;s neutral protamine insulin (NPH) and/or regular insulin; who collect these medicines from the Municipal Pharmacy of Ijuí; between 35 and 70 years old; with autonomy to use medications and apply insulin; who do not need a caregiver; with changes in capillary blood glucose previously measured in a pharmacist&apos;s office (blood glucose levels above 180 mg/dL at any time of the day).	Patients with type 1 diabetes mellitus (DM1); pregnant women; under 35 years old and over 70 years old; with circumstances that do not allow filling out the questionnaires (inability to speak, see or hear); those with a medical diagnosis of cognitive impairment; those that are banned; those who do not agree to participate in the research; those who do not sign the Free and Informed Consent Form (TCLE).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-2s664yk	Evaluation of single Total Crowns made of Zirconia Reinforced Lithium Silicate	Recruiting	Intervention	2024-07-24	<NULL>	<NULL>	7156	Evaluation of Zirconia Reinforced Lithium Silicate single Crowns fabricated in CAD/CAM System: split-mouth randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Centro de Pesquisa Clínica	https://ensaiosclinicos.gov.br/rg/RBR-2s664yk	<NULL>	Participants aged 18 to 60, no specific gender; who have indication for full crowns on posterior permanent teeth; who are available to clinical monitoring throughout the evaluation period; willing and able to go through periapical/interproximal radiographic examination when necessary; be in accordance with the Terms Free and Informed Consent (TCLE); general health consistent with the period of clinical assessment; adequate maxillomandibular relationship and occlusal stability	History of allergy to any of the materials to be used in the search; pregnancy at the beginning of the experiment; use of drugs that may interfere with the environment oral; systemic diseases with the possibility of altered immunity and risk of infection in the start of study; impossibility of being subjected to specific techniques for carrying out the search; insufficient space for proper creation of crowns; habit holders parafunctional; abutment teeth that, endodontically and periodontally, do not present predictability until the end of the evaluation period; periodontal disease; high risk of caries; unsatisfactory oral hygiene; use of removable partial dentures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-777nzpz	Effect of Gum Treatment in Diabetic Patients	Recruiting	Intervention	2024-07-24	<NULL>	<NULL>	7158	Impact of Periodontal Disease and the Expression of Cytokines Associated with T Helper 17 and Regulatory T Cells on the Metabolic Control of Patients with Type 2 Diabetes Mellitus	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-30	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-777nzpz	<NULL>	Patients aged ≥ 30 and ≤70 years; Diagnosis of periodontitis according to the classification of periodontal conditions and diseases with interproximal clinical attachment level (CAL) ≥ 2 or CAL≥ 3 mm in more than 2 non-adjacent teeth (excluding the CAL limits cited in cases related to periodontitis: gingival recession of origin traumatic; dental cavities extending into the cervical area of ​​the teeth; presence of CAL in the distal part of the second molar and associated with poor dental position or extraction of the third molar; endodontic lesion reaching the gingival margin and occurrence of vertical root fracture. Participants should also present at least 4 sites with probing depth (PD) ≥4mm with bleeding on probing (BP); present at least 15 teeth, excluding third molars and be diagnosed with type 2 diabetes mellitus (DM2) (HbA1c &gt; 6.5% ) in the DM2 group and absence of DM2 diagnosis (HbA1c ≤ 6.5%) in patients in group P	Received prior non-surgical periodontal treatment within 6 months of the study; Had used antibiotics and anti-inflammatories within three months before the start of the study; Women were pregnant or breastfeeding; Use of immunosuppressants and/or have blood disorders; Were undergoing orthodontic treatment; If they needed prophylactic antibiotic therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-52r82gy	Comparative study of donated corneas with and without Descemet&apos;s membrane in corneal transplants with perforation during surgery	Not yet recruiting	Intervention	2024-07-23	<NULL>	<NULL>	7148	Comparison of donated corneas with and without Descemet&apos;s membrane in deep anterior lamellar corneal transplantation with intraoperative perforation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-15	Hospital Oftalmológico de Sorocaba	Hospital Oftalmológico de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-52r82gy	<NULL>	Patients 18 years of age or older; patients indicated for  deep anterior lamellar keratoplasty (DALK) by the Hospital Oftalmológico de Sorocaba (HOS); patients who agree to participate in the study	Patients who do not present intraoperative perforation of the Descemet&apos;s membrane; patients requiring conversion to penetrating keratoplasty (PK); pregnant or breastfeeding woman; patients who at some point give up participating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-8m2fv2b	Single Shade Composite Resin color camouflage: randomized clinical trial	Recruiting	Intervention	2024-07-22	<NULL>	<NULL>	7146	Color matching of single shade composite resins: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-26	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8m2fv2b	<NULL>	Volunteers aged between 18 and 70 years; with indication for direct incisal reconstruction in composite resin; attended at the Removable Partial Dentures extension project of the Dentistry Course at the Federal University of Santa Catarina	Individuals with pronounced incisal wear requiring indirect reconstruction; presence or history of painful symptoms and/or temporomandibular disorder treatment; presence of uncontrolled systemic disease; patients with mental disorders, dementia, Alzheimer&apos;s, or cognitive disorders; previous periodontal disease with residual dental mobility; smokers and/or alcoholics; pregnant or breastfeeding women will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-6ktzzh8	Affective experience and opioid use before anesthesia: a double-blind randomized clinical trial	Not yet recruiting	Intervention	2024-07-22	<NULL>	<NULL>	7147	The affective experience and use of opioids before anesthetic induction: a double blind randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-08-10	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Faculade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6ktzzh8	<NULL>	Both genders; age range between 18 and 65 years old; classified according to surgical risk as ASA 1 or ASA 2 or ASA 3; according to medical assessment based on health history, physical examination and laboratory tests; subjected to previously scheduled surgery, and may or may not be hospitalized with general anesthesia	"Physical or intellectual inability to respond to the questionnaires, as assessed by the researchers;
Illiterate; patients who have a previous history of an allergic reaction to opioids; chronic opioid users;
users of psychoactive drugs for recreational use; patients with nephropathy, pacemakers and beta blockers"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-7n2srw8	Cardiovascular and functional effects, health-related benefits and safety of different intensities of community-based exercise in older women under socioeconomic vulnerability: The COmmunity-Based EXercise in OLD age (COBEX-OLD) study	Recruiting	Intervention	2024-07-21	<NULL>	<NULL>	7145	Cardiovascular and functional adaptations, health-related outcomes and safety of different intensities of community-based exercise in older women under socioeconomic vulnerability: The COmmunity-Based EXercise in OLD age (COBEX-OLD) study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Estadual Paulista - UNESP	Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7n2srw8	<NULL>	To be women (feminine sex) under socioeconomic vulnerability; age equal or greater than 60 years; do not have participated in structured physical exercise programs during the three months prior to the enrollment in the study; do not have uncontrolled cardiovascular or metabolic diseases; do not have musculoskeletal, neurological or pulmonary disorders that impair physical exercise participation	Do not return for follow-up evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-9mtwh2j	Effectiveness of technologies in maintaining venous access in hospitalized children and adolescents	Not yet recruiting	Intervention	2024-07-19	<NULL>	<NULL>	7143	Effectiveness of technologies in the Maintenance of short Peripheral Intravenous Catheters in hospitalized children and adolescents (ManCIP)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-22	Universidade Estadual de Feira de Santana	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-9mtwh2j	<NULL>	Age between 1 and 14 years old. Intravenous therapy peripherally for 48 hours or more. Use of a Short Peripheral Intravenous Catheter for intermittent or continuous medication administration	Children who request to withdraw their consent or whose parents no longer consent to their participation during follow-up and children who remove the Short Peripheral Intravenous Catheter accidentally or on their own will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-37hyg6c	Monitoring Lung nodules in people at high risk for Lung cancer	Recruiting	Observational	2024-07-19	<NULL>	<NULL>	7144	Lung nodule Detection and monitoring program in a population at high risk for Lung cancer	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-01	Servico Nacional de Aprendizagem Industrial - SENAI CIMATEC	Santa Casa de Misericordia da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-37hyg6c	<NULL>	Individuals of both genders; aged between 50 and 80 years; smokers or ex-smokers for a maximum of 15 years; smoking history of 20 pack-years or more	Individuals unable to undergo tomography; individuals with symptoms highly suggestive of lung cancer (hemoptysis, chest pain, change in cough pattern, unintentional weight loss greater than 10 kg); history of radiation therapy to the chest region; individuals undergoing cancer treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-10fsg6j7	LASER application after orthognathic surgery in patients with cleft lip and palate	Recruiting	Intervention	2024-07-18	<NULL>	<NULL>	7142	Use of Photobiomodulation in patients with Cleft Lip and palate undergoing Orthognathic Surgery - Analysis with Infrared Thermography	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10fsg6j7	<NULL>	Individuals with repaired cleft lip and palate; at least 18 years old; of both sexes; without systemic comorbidities; submitted to bimaxillary orthognathic surgery to correct maxillomandibular discrepancies	Individuals who were not born with cleft lip and palate; smokers; pregnant women; individuals with lymphatic diseases or disorders and immunocompromised individuals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-776sk7w	Clinical assessment of adhesive restorations in head and neck irradiated patients	Recruiting	Intervention	2024-07-17	<NULL>	<NULL>	7141	Clinical assessment of the longevity of class V adhesive restorations in head and neck irradiated patients - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-776sk7w	<NULL>	Individuals submitted to radiotherapy for head and neck cancer with the need and indication for class V restoration in at least one tooth; age 18 or above; both genders; and who agree to participate in the research by reading and signing the Informed Consent Form (ICF)	Individuals submitted to radiotherapy for head and neck cancer who have teeth in need of endodontic treatment or indirect restorations; individuals who do not wish to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-3gbr5h7	Influence of torque, bone type and bone loss on the stability of cylindrical external hexagon and morse cone implants with new surface treatment	Other	Intervention	2024-07-16	<NULL>	<NULL>	7138	Influence of insertion torque, recipient bone type and peri-implant bone loss on the primary and secondary stability of external hexagon and morse cone cylindrical implants with new surface treatment	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-03-14	Faculdade de Odontologia - Campus de Araçatuba da Universidade Estadual Paulista	Faculdade de Odontologia - Campus de Araçatuba da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-3gbr5h7	<NULL>	Age between 18 and 60 years; cognitive capacity; presence of healthy tissues and satisfactory bone quantity and quality; with need for rehabilitation with single or three element implant supported prostheses with pontic	Patients with parafunction; as well as those with harmful habits and addictions; such as drug users; alcohol abusers and smokers; patients with systemic disorders (diabetes; transplant patients) or who use medications that alter bone metabolism (corticoids; cyclosporine A; radiotherapy) and patients in need of bone grafting	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-68j3f26	Treating Endometriosis: Pill of Dienogest alone vs. Pill of Dienogest with Hormonal Intrauterine Device - a randomized clinical trial	Not yet recruiting	Intervention	2024-07-16	<NULL>	<NULL>	7139	Endometriosis treatment with Dienogest Monotherapy or Dienogest associated to Intrauterine Dispositive of Levonorgestrel - a randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Estadual de Campinas	Hospital da Mulher José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-68j3f26	<NULL>	Women aged 18 to 45 years. Diagnosis of endometriosis by specific imaging examination ultrasound, magnetic resonance imaging (MRI). Present at study entry with complaints of pelvic pain and/or deep dyspareunia. Agree to the use of dienogest or levonorgestrel intrauterine device (LNG IUD). No contraindications to the use of levonorgestrel intrauterine device (LNG IUD). No desire for pregnancy during the one-year study period	Asymptomatic women. Women who have not initiated sexual activity. Women with psychiatric or neurological disorders that compromise the ability to respond to the questionnaires developed such as schizophrenia, neurodegenerative disorders, severe depression. Women undergoing treatment for chronic systemic diseases that lead to painful symptoms fibromyalgia, interstitial cystitis, neuropathic pain. History of abdominal surgery hysterectomy, colectomy, exploratory laparotomy, complicated appendectomy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-86my7w2	Evaluation of the effects of Laser associated with Transcutaneous Electrical Nerve Stimulation and Hot Water Bags in the control of Temporomandibular Disorder	Recruiting	Intervention	2024-07-16	<NULL>	<NULL>	8409	Evaluation of the effects of Laser Photobiomodulation Therapy associated with Transcutaneous Electrical Nerve Stimulation and Thermotherapy in the control of Temporomandibular Disorder: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Estadual de Feira de Santana	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-86my7w2	<NULL>	Have female biological sex; be at least 18 years old; present pain intensity of 3 or higher measured by the visual analogue scale; present pain for a period greater than or equal to 3 months; possibility of attending the orofacial pain clinic at the State University of Feira de Santana 3 times a week during the treatment period (Monday and Wednesday in the afternoon and Friday in the morning); be diagnosed with Muscular Temporomandibular Disorder, using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD)	Patients with a history of temporomandibular joint surgery; Orofacial Pain caused by Neoplasms or Odontogenic Problems; patients who have already undergone treatment for Temporomandibular Dysfunction; continuous use of non-steroidal anti-inflammatory drugs, analgesics, antidepressants or muscle relaxants; patients who have Intracranial, Neurological Disorders or other major causes of Headache; have been diagnosed with Arthralgia in the temporomandibular joint and patients who already knew how Transcutaneous Electrical Stimulation works	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:54
RBR-8kdv3pt	Effects of Light Therapy and Manual Manipulation Technique on improving physical capacity and reducing pain in adults subjected to Muscle Damage	Not yet recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7132	Effects of Photobiomodulation and Osteopathy on blood and salivary parameters, pain perception and physical performance in young adults undergoing Muscle Damage induced by physical exercise	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Universidade Federal de Jataí	Universidade Federal de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-8kdv3pt	<NULL>	The study will include male people; aged between 18 and 35 years; Caucasian and unused to performing plyometric jumps in their usual training; Participants must also have at least 6 months of experience with resistance training	Individuals who use nutritional supplements or anti-inflammatory and pain medications in the last seven days will be excluded; having consumed alcohol or ergogenic drinks 72 hours before the tests; present musculoskeletal injury; not carrying out all the collection stages and/or giving up during the study; practitioners of sports that involve plyometric jumps	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-557c2cz	Use of Myoinositol in patients with Polycystic Ovary Syndrome who will undergo a procedure to try to get pregnant	Not yet recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7133	Myoinositol as adjuvant therapy in patients with Polycystic Ovary Syndrome undergoing Assisted Reproduction procedures	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-08-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-557c2cz	<NULL>	Women; between 18 and 40 years of age; with a body mass index between 18 and 34,9 kg/m2; diagnosed with Polycystic Ovary Syndrome according to the Rotterdam criteria; diagnosed with marital infertility according to the World Health Organization criteria; who agree to sign the Term of Free and Informed Consent	Presence of other diseases that cause hyperandrogenism (non classic congenital adrenal hyperplasia, hyperprolactinemia, thyroid diseases without adequate control, androgen secreting tumors, Cushing&apos;s Syndrome); Type 1 diabetes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-7w75qby	Pharmacological Therapy for the treatment of Obstructive Sleep Apnea: a randomized clinical trial	Not yet recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7134	Reboxetine and Oxybutynin for the treatment of Obstructive Sleep Apnea: a randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-09-01	Departamento de Cirurgia da Universidade Federal do Rio Grande do Norte	Departamento de Cirurgia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7w75qby	<NULL>	Patients aged 18 years or older diagnosed; both genders; with Obstructive Sleep Apnea according to the criteria of the American Academy of Sleep Medicine (AASM).	Pregnant patients; cognitive disorders that prevent understanding to provide consent and adequate use of proposed therapies; use of medications or drugs that have a known interaction with the proposed therapy; allergy to any of the components of the proposed therapies; angle-closure glaucoma; partial or total obstruction of the gastrointestinal tract; paralytic ileus; intestinal atony in the elderly; megacolon; toxic megacolon; complication of ulcerative colitis;  severe colitis; myasthenia gravis; unstable cardiovascular status due to acute hemorrhage; obstructive uropathy or urinary retention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-6xww44w	Clinical interventions in the care of hospitalized newborn	Recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7136	Clinical interventions in the care of hospitalized newborn: protection and promotion of neurodevelopment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual de Feira de Santana	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-6xww44w	<NULL>	Gestational age less than 37 weeks; after seven days of life; clinically stable (heart rate between 120 and 180 beats per minute, respiratory rate between 35 and 60 breaths per minute and oxygen saturation greater than or equal to 95% in the last 24 hours); kept inside incubators; 24 hours after the end of phototherapy treatment; both genders	In phototherapy; using invasive and non-invasive mechanical ventilation; with any type of congenital malformation; with periventricular hemorrhage grades II, III and IV; using central nervous system depressant medications, opioid analgesics and sedatives in the last 24 hours; using corticosteroids; in need of surgery of any nature; whose mother has a history of using any illicit drugs or antidepressants during pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-6mtkqcq	Cardiopulmonary and functional rehabilitation after COVID-19	Recruiting	Intervention	2024-07-15	<NULL>	<NULL>	7137	Recover- Cardiopulmonary and Functional Rehabilitation in COVID-19 survivors	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Ciências Socias Aplicadas	Fundação Pedro Américo	https://ensaiosclinicos.gov.br/rg/RBR-6mtkqcq	<NULL>	Patients of both genders; who prove two negative rt-PCR tests for COVID-19 carried out at the place of hospitalization following criteria for hospital discharge of severely ill patients (CDC, 2021); who developed the severe form of the disease measured by the clinical progression scale proposed by the World Health Organization (WHO) (MARSHALL et al., 2020); who were hospitalized and admitted to the intensive care unit (ICU), intermediate care unit or ward, undergoing invasive (via orotracheal tube or tracheostomy) or non-invasive mechanical ventilation and oxygen therapy (high-flow nasal catheter or mask with reservoir bag ); and who were discharged from hospital at least 30 days before the start of rehabilitation	Participants who confirm reinfection will be excluded from the study; rehospitalization and hospitalization (MARSHALL et al., 2020); hemodynamically unstable patients (uncontrolled blood pressure and heart rate); unstable medical conditions, for example cardiovascular and pulmonary disorders (arrhythmias, decompensated atrial fibrillation, pulmonary thromboembolism, acute heart failure, pulmonary congestion, acute myocardial infarction and stroke); musculoskeletal and neurological conditions that affect mobility (paraplegia, tetraplegia, amputations and severe joint deformities); or cognitive and dementia conditions that make it impossible to answer the questionnaires and perform the exercise protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-9857xj3	Impact of physical exercise on heart and skeletal muscle health	Not yet recruiting	Intervention	2024-07-12	<NULL>	<NULL>	7131	Evaluation of the effect of a physical exercise program on the muscular and vascular health of elderly individuals	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-08-15	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-9857xj3	<NULL>	Elderly people (over 60 years of age); male and female sex; high triglycerides (&gt;150 mg/dL); reduced HDL-cholesterol (&lt;50 mg/dL for men and &lt;40 mg/dL for women); waist circumference &gt; 102 cm for men and &gt; 88 cm for women; hypertensive (systolic pressure above 130 mm Hg and diastolic pressure above 90 mm Hg); and increased fasting blood glucose (&gt; 100 mg/dL) or diagnosed with type II diabetes mellitus; with or without a diagnosis of common mental disorder (anxiety and/or depression). Young people (over 18 years old); male and female sex; sedentary or physically active; no musculoskeletal diseases; with or without the presence of risk factors for cardiovascular diseases; with or without a diagnosis of common mental disorder (anxiety and/or depression)	Osteoarthritis and rheumatoid arthritis; infected with HIV virus; use of drugs that interfere with the vascular and nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-4qv57kj	Implementation and effectiveness of an Integrative Practice Protocol as an aid to common treatment in reducing symptoms of Depression for patients in primary health care	Recruitment completed	Intervention	2024-07-11	<NULL>	<NULL>	7130	Implementation and effectiveness of an Integrative Practice Protocol as an adjuvant to usual treatment in reducing depressive symptoms for patients of primary healthcare	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-26	Hospital do Câncer de Barretos/Fundação PIO XII	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4qv57kj	<NULL>	Participants between 18 and 69 years old; be part of the coverage area of ​​the Primary Health Care territories managed by Social Organization Pio XII or be part of the staff or dependent on medical health care; being treated with antidepressants in a therapeutic dosage and/or undergoing individual psychotherapy for at least one month	Patients diagnosed with Bipolar Affective Disorder and/or psychotic disorders; patients who presented suicidal ideation with planning; patients with a history of trauma to the brain region; patients with neurocognitive disorders; patients who are using psychoactive substances in a pattern of risk and/or dependence; been recently bereaved (less than 6 months), or have symptoms of complicated grief; patients who have a score greater than 15 on the PHQ-9; patients who report frequent meditation practice in the last year	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-9sfj4rz	Evaluation of Photobiomodulation in topical anesthetic absorption and pain reduction during Local Infiltrative Anesthesia	Data analysis completed	Intervention	2024-07-09	<NULL>	<NULL>	7126	Use of Photobiomodulation to help in the absorption of topical anesthetics and reduction of pain during Local Infiltrative Anesthesia in the dental clinic	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2022-10-30	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9sfj4rz	<NULL>	Patients who require at least 2 infiltrative anesthesias to carry out their dental treatment plan. Anterior teeth or premolars. Patients without systemic impairment. Patients aged between 18 and 50 years. Both genders	Patients who are undergoing antidepressant or antipsychotic drug treatments. Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-2zx5y9r	Use of the Placental Growth Factor (PlGF) test in pregnant women with Chronic Hypertension to evaluate superimposed Pre-eclampsia	Not yet recruiting	Intervention	2024-07-09	<NULL>	<NULL>	7127	Implementation of the PlGF test to evaluate superimposed Pre-eclampsia in pregnant women with Chronic Arterial Hypertension: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2zx5y9r	<NULL>	All pregnant women diagnosed with chronic hypertension and clinical suspicion of superimposed preeclampsia (due to worsening blood pressure control); age over 18 years; gestacional age over 20 weeks; exacerbated weight gain; emergence or worsening of proteinuria; signs of placental insufficiency after 20 weeks of gestation	HELLP syndrome; eclampsia; signs of imminent eclampsia; hypertensive crisis, when systolic blood pressure ≥160 and/or diastolic blood pressure ≥110mmHg; acute fetal distress	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-4nh7hnt	Evaluation of heated anesthetic during anesthesia in children	Recruitment completed	Intervention	2024-07-09	<NULL>	<NULL>	7128	Evaluation of the effect of heated local anesthetics on pain during infiltrative dental anesthesia in children requiring dental treatment of lower primary molar: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4nh7hnt	<NULL>	Children between 7 and 10 years old are eligible; no systemic compromise; ASA I and II; both sexes; previous experience or not with dental anesthesia; need for dental treatment such as extractions, restorations and endodontic treatment in deciduous lower molars	Patients with acute pain; presence of odontogenic infection; emergency cases; history of bleeding or blood clotting problems; history of allergy to the drugs used in the research; history of asthma; liver disease; neurological disorders; use of analgesic or anti-inflammatory medication up to 5 hours before the procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-8797spr	Effect of educational video on parents&apos; knowledge about caring for premature newborns at home	Recruiting	Intervention	2024-07-09	<NULL>	<NULL>	7573	Self-efficacy of audiovisual educational technology in parental knowledge about caring for premature newborns at home	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-05-25	Universidade Federal do Piauí	Nova Maternidade Dona Evangelina Rosa	https://ensaiosclinicos.gov.br/rg/RBR-8797spr	<NULL>	Mothers of premature and/or low birth weight newborns hospitalized for more than 24 hours in the neonatal unit. Members of the family and/or social support network will be included, who are primarily responsible for the newborn during hospitalization, whether literate or not	Mothers with hearing impairments and/or psychiatric illnesses (puerperal dysphoria, panic disorder and obsessive-compulsive disorder) that make it impossible to answer the questionnaires; withdrawal from the research after the start of data collection, or non-participation in all stages of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-96x28w8	The tactical performance of football players under Cerebral Stimulation	Not yet recruiting	Intervention	2024-07-08	<NULL>	<NULL>	7123	Ergogenic effect of Transcranial Continuous Current Stimulation on the tactical performance of football players	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-96x28w8	<NULL>	Participants over 18 years old up to 40 years old; fit to play football; Participants without injuries	Participants with injury; injured participants; participants returning from injury; participants who consume psychoactive and psychodepressant medications; participants who have a history of depression and epilepsy; participants who are absent twice consecutively; participants with any cardiovascular, osteo-articular and central problem for physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-10gky7y9	Effect of Time Under Tension in Recreational Runners	Recruiting	Intervention	2024-07-08	<NULL>	<NULL>	7124	Acute Effect of Isometric Strength Training and Time Under Tension on the Performance of Recreational Runners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-18	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-10gky7y9	<NULL>	Volunteer for research; be 18 years of age or older; run at least three times a week with an average weekly mileage of 16 kilometers; have an average running pace of between 5 and 5:30 minutes per kilometer over a long distance; participate in a strength training program at least once a week with at least three months of practice, report no osteoarticular injuries during the last three months that compromised strength exercises and running; and have at least one year&apos;s experience in long-distance running	Individuals who do not perform all steps as instructed; present depravity in the upper respiratory tract; injuries that make it impossible to perform maximum effort during the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-10h3q6sx	Development of new rehabilitation methods to recovery post-stroke patients	Recruiting	Intervention	2024-07-06	<NULL>	<NULL>	7122	Development of new rehabilitation methods for post-stroke patients using brain-computer interface based on motor imagery, virtual reality and robotic devices	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal do Espirito Santo (UFES)	Centro de Reabilitação Física do Estado do Espírito Santo (CREFES)	https://ensaiosclinicos.gov.br/rg/RBR-10h3q6sx	<NULL>	Both genders. Age: over 18 years. Post Stroke: 3 months to 1 year. With residual weakness of affected lower limb. Preserved cognition: MoCA (Montreal Cognitive Assessment ) ≥ 26.  Independence in walking: ability to walk 10 m unaided, speed&gt; 0.4 m/s, with or without assistive device. Spasticity: MAS (Modified Ashworth Scale) ≤ 2	History of more than 1 stroke. Bilateral affection. Vestibular disorders / dizziness. Skin lesions at the electrode site. Osteoporosis. Comorbidities: contractures, severe knee osteoarthritis. Residual flaccidity in lower limbs. Taking anticonvulsant or neuroleptic medicines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-7rg2tq3	Effect of Osteopathy in individuals with Reflux of stomach contents into the esophagus on quality of life and on the surface temperature of the thoracic region	Recruitment completed	Intervention	2024-07-04	<NULL>	<NULL>	7119	Effect of Osteopathic Treatment in individuals with Gastroesophageal Reflux Disease on quality of life and surface temperature of the thoracic region: preliminary randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7rg2tq3	<NULL>	Diagnosis of Gastroesophageal Reflux Disease (GERD) after medical diagnosis of acid reflux; with upper digestive endoscopy and/or Impedance-pHmetry confirming esophagitis and/or hiatal hernia; or score above 4 on the Health-Related Quality of Life Scale for Gastroesophageal Reflux Disease (GERD-QVRS); age between 18 and 60 years; residents of greater Florianópolis	Previous surgery of the lower esophageal sphincter; peptic ulcer; previous gastric cancer or present cancer; systemic diseases and/or inflammatory symptoms (rheumatoid arthritis; fever; hypertension; fibromyalgia; etc.); neurological or orthopedic diseases that may interfere with the proposed intervention; pregnancy; recent fracture or open wounds; constant use of vasoactive medications; patients who received any treatment using manual techniques	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-26jjmzm	Psychological intervention pProtocol for promoting Healthy Ageing	Not yet recruiting	Intervention	2024-07-04	<NULL>	<NULL>	7120	Personality change focused on Healthy Aging: proposing and evaluating the validity of a psychological intervention protocol	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Centro Universitário Estácio de Sá de Santa Catarina	Centro Universitário Estácio de Sá de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-26jjmzm	<NULL>	minimum level of secondary education completed; interest and willingness to participate in the research for a period of one year; ability to answer psychological instruments	be under the age of 18; undergoing psychotherapy; undergoing psychiatric treatment or taking psychiatric medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-25vq2fz	Effect of distortion bias in pediatric dentistry studies: a randomized controlled trial	Recruiting	Intervention	2024-07-03	<NULL>	<NULL>	7115	The effects of Spin in the abstracts of articles reporting results of randomized controlled trials in pediatric dentistry: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-06	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-25vq2fz	<NULL>	Any dentists who treat children in their clinical practice regardless of their specialty	Dentists who do not treat children in their clinical routine; dentists that do not want to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-3b557kx	Effect of beetroot juice ingestion on strength	Recruiting	Intervention	2024-07-03	<NULL>	<NULL>	7116	Effects of nitrate supplementation on strength endurance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3b557kx	<NULL>	Males; adult; 6 months of uninterrupted experience in strength training	neuromuscular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-109j9jww	Open bite treatment with fixed palatal crib with and without myofunctional therapy: a randomized clinical trial	Other	Intervention	2024-07-03	<NULL>	<NULL>	7117	Efficacy and efficiency of open bite treatment with fixed palatal crib with and without myofunctional therapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-109j9jww	<NULL>	Mixed dentition; 6 to 8 years of age; both genders; presence of permanent first molars and central incisors in the dental arches; overbite of -1millimeter or less; absent or mild dental crowding; absence of posterior crossbite; history of at least one deleterious habit	Patients with history of previous orthodontic treatment; presence of dental or supernumerary agenesis; loss of permanent teeth; presence of craniofacial anomalies and associated syndromes or any other type of systemic or neurological alteration that would make it impossible to perform the procedures of intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-8ys44sz	Education and technology as aid in weight loss	Recruitment completed	Intervention	2024-07-01	<NULL>	<NULL>	7112	Education in changing one&apos;s lifestyle to cope with excess weight with the use of information technologies	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-26	Fundação São Paulo - Campus Sorocaba da PUC-SP Fac Ciencias Med e da Saúde	Fundação São Paulo - Campus Sorocaba da PUC-SP Fac Ciencias Med e da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8ys44sz	<NULL>	Patients and staff registered at the Basic Health Unit of Parque São Bento, Sorocaba, São Paulo; both genders (male and female); aged between 20 and 59 years; diagnosed with overweight or obesity according to Body Mass Index classification; familiar with the use of mobile technologies such as WhatsApp on their smartphones; interested in the prevention and control of overweight and obesity through a healthy lifestyle	Individuals who chose not to participate in the project; lack of access or familiarity with mobile technology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-7t6g86c	Evaluation of the effects and experience of using the SOPeD Exercise program for Feet and Ankles by individuals with Diabetic Foot: a randomized clinical trial	Recruitment completed	Intervention	2024-07-01	<NULL>	<NULL>	7113	Evaluation of the effects and subjective experience of using the SOPeD Exercise software for Feet and Ankles by individuals with Diabetic Foot: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7t6g86c	<NULL>	Individuals aged between 18 and 75 will be included; without distinction of race, sex or gender; residents of the city of Belo Horizonte/MG; diagnosis of type 1 or 2 diabetes mellitus, at high risk of foot ulceration (classification 3 in the International Working Group on the Diabetic Foot - IWGDF criteria), diagnosis of neuropathic diabetic foot (Peripheral Diabetic Neuropathy - moderate DPN - score 5.0 less than or equal to x less than 8.0 or severe - score greater than or equal to 8.0) according to the Decision Support System for the Classification of Diabetic Polyneuropathy, using Fuzzy logic, non-ischemic (ischemia equal to 0 according to the WIfI Classification proposed by the Society for Vascular Surgery); ulceration and/or minor amputation in only one of the lower limbs (LL); previous independence in functional mobility with or without the use of an assistive device; absence of dementia or signs of cognitive changes measured by the Mini-Mental State Examination (MMSE); access to an electronic device with internet access (computer, tablet, smartphone); who have the presence of another person in their home for support; and who accept to participate in the study and sign the Free and Informed Consent Form (TCLE).	It will be excluded from the study those who: have previous major amputation in lower limbs; present a new injury or amputation during the study that prevents the execution of the exercise program; are or will undergo any type of motor rehabilitation in lower limbs during the study; have already undergone orthopedic surgery on the lower limbs; have an indication for surgery or arthroplasty; readmission in hospitals during the study; presenting rheumatological and neurological diseases; have severe visual impairment such as severe diabetic retinopathy; aphasia, mental, behavioral or mood disorders diagnosed and recorded in the medical record document.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-2q4ht7r	Bicalutamide associated with oral Minoxidil for the treatment of female baldness	Data analysis completed	Intervention	2024-07-01	<NULL>	<NULL>	7114	Efficacy and safety of Bicalutamide 25 mg associated with Minoxidil 1 mg oral versus Minoxidil 1 mg oral for treating female pattern Alopecia: double-blind and randomized clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-09-12	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2q4ht7r	<NULL>	Patients diagnosed with Female Pattern Alopecia (stages II, III, IV and V of the Sinclair Scale); patients with a minimum age of 18 years and a maximum age of 60 years; female patients	Any type of previous alopecia treatment in the past 4 months; patients with diagnosis of Systemic Arterial Hypertension; cardiopaths patients; hepatophats patients; nephropats patients; patients with any other cause of hair loss besides Female Pattern Hair Loss; patients with pregnancy intention in the next 12 months; patients in fertile age that wont agree in the use of secure contraceptive methods; patients who, during the clinical trial, present an increase in liver enzymes greater than two and a half times the upper limit of normality	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-6kzpwyk	Salivary Cortisol level to assess Anxiety of children before surgery with the use or not of medicine	Not yet recruiting	Intervention	2024-06-28	<NULL>	<NULL>	7111	Salivary Cortisol and preoperative Anxiety level of children with the use or not of pre-medication: clinical trial	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2024-10-01	Instituto de Medicina Integral Professor Fernando Figueira	Instituto de Medicina Integral Professor Fernando Figueira	https://ensaiosclinicos.gov.br/rg/RBR-6kzpwyk	<NULL>	Children aged 2 to 9 years; both genders; indication of small and medium-sized elective surgery; literate responsible	Children who receive chronic medications that depress the central nervous system, such as for the treatment of autism spectrum disorder, attention deficit hyperactivity disorder; american society of anesthesia classification greater than II; use of corticosteroids; carrying out dental treatment in the 24 hours before surgery; surgeries performed after 10 am, a time defined due to the circadian cycle, which causes a bias in the collection of salivary cortisol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-4pvhhg5	The Use of Laser in Runners with Achilles Tendonitis using Vascular Points Technique: A clinical, longitudinal, Interventional Study	Not yet recruiting	Intervention	2024-06-27	<NULL>	<NULL>	7107	Photobiomodulation in Runners with Achilles Tendinopathy using the Vascular Points Technique: Clinical, longitudinal, interventional study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade São Francisco - USF	Universidade Federal de São Paulo - Unifesp	https://ensaiosclinicos.gov.br/rg/RBR-4pvhhg5	<NULL>	Volunteers with insertional calcaneal tendon tendinopathy or in the tendon body, both genders, age between 18-55 years, runners (minimum 10-50 km per week) are in activity that present: symptoms and/or functional disability: VISA-A (&lt;80); Numerical pain scale (&gt;4) during running activity; pain at tendon palpation; modified Blazin &gt; 3; Evaluation of symptoms and functional capacity in Heel Rise and unipodal jump	Volunteer who has a history of previous lower limb surgery ; any physiotherapeutic treatment for calcaneal tendon tendinopathy in the last 6 months; individuals with a history of recent fracture and/or calcaneal tendon rupture; history of prolonged use of corticosteroids and/or anabolic steroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-4ttgs2j	Contribution of cardioprotective dietary guidance on Inflammation and Oxidative Stress after Myocardial Infarction and Stroke in volunteers assisted at a SUS reference service in the state of Alagoas, Brazil	Recruitment completed	Intervention	2024-06-27	<NULL>	<NULL>	7108	Contribution of cardioprotective dietary guidance on Inflammatory and Oxidative Stress markers in obese adults and elderly survivors of Stroke and Acute Myocardial Infarction in a SUS Reference Service in the State of Alagoas	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-03	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-4ttgs2j	<NULL>	Volunteers who survived Acute Myocardial Infarction (AMI) and Cerebrovascular Accident (CVA), hospitalized for treatment of these conditions. Aged ≥ 20 years. Of both sexes. Obese (coexistence of overweight and body fat in obese adults and elderly – Body Mass Index BMI≥ 25 kg/m2 and &gt; 27 kg/m2, for adults and the elderly, respectively, i.e., overweight BMI for both age groups and, necessarily, increased waist circumference (WC) ≥ 80 cm increased for women and ≥ 90 cm for men) and/or excess body fat according to Triceps Skinfold (PCT) - TSF &gt; 95th percentile for sex and age OR % adequacy &gt; 120% when the PCT obtained / PCT percentile 50 x 100 &gt; 120%, increased WC and PCT constitute obesity/excess adipose tissue, in individuals with overweight/overweight BMI). Clinically stable. With conditions for telephone contact and/or other form of remote contact after hospital discharge	Individuals hospitalized for treatment of Acute Myocardial Infarction (AMI) and Cerebrovascular Accident (CVA). With – Body Mass Index BMI &lt; 25 kg/m2 (adults) and &lt;= 27 kg/m2 (elderly). Clinically unstable. With special needs (assisted feeding, such as enteral feeding). No conditions for telephone contact and/or other form of remote contact after hospital discharge. Pregnant or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-4bxpkbb	A New Lung Treatment Device for Adult Patients with a Breathing Tube: a Randomized Controlled Clinical Trial	Not yet recruiting	Intervention	2024-06-27	<NULL>	<NULL>	7109	A new Lung Expansion Device for adult Tracheostomized patients: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Fundação Universidade Federal Do Amapá	Fundação Universidade Federal Do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-4bxpkbb	<NULL>	Adult patients aged 18 and over. Hospitalized patients. Patients without impairment of cognition and understanding	Patients requiring invasive mechanical ventilation. Tracheostomy patients due to neuromuscular diseases or spinal cord injury. Patients who withdraw from participating in the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-6wssng7	Effect of Gentle Touch in children with Cerebral Palsy	Recruiting	Intervention	2024-06-27	<NULL>	<NULL>	7110	Effect of Gentle Touch on cardiac autonomic modulation in children and adolescents with Cerebral Palsy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-11	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-6wssng7	<NULL>	Individuals with cerebral palsy for the CP group and with typical development for the TD group; be between 5 and 18 years old; being able to remain at rest for the application of the assessment and intervention protocol	Have heart disease;  have respiratory diseases; have metabolic diseases; who use medications that alter the autonomic control of heart rate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-9zvtc5b	Assessment of functional capacity, falls, frailty and vulnerability of elderly people	Not yet recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7098	Assessment of functional capacity, falls, frailty and clinical-functional vulnerability of frail and non-frail elderly people	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Ana Paula Felix Arantes	Centro de Referência em Hipertensão e Diabetes	https://ensaiosclinicos.gov.br/rg/RBR-9zvtc5b	<NULL>	Elderly people over the age of 60 years; elderly people which are not included in a regular physical exercise program	Elderly people who might have any clinical conditions that contraindicate the practice of physical activity; elderly people with cognitive deficits that might limit the performance of assessments and/or interventions (present under 19 points on the Mini Mental State Examination)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-6xfb4xs	Evaluation over time of facial structures in adult patients receiving Treatment for Pain in the Mouth Joint associated with Cannabidiol gel	Recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7099	Longitudinal Analysis of the stomatognathic system in adult patients undergoing Treatment for Muscular Temporomandibular Disorder associated with Cannabidiol	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-11	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6xfb4xs	<NULL>	Female participants; have natural teeth; have first permanent molars; with normal occlusion; painful temporomandibular disorder of the refractory myofascial pain type; age between 20 and 50 years; no decompensated systemic diseases	Presence of ulcerations, open wounds with discontinuation of the skin surface; allergy to cannabis formulation; hypersensitivity to the substances to be used in the study; presence of cognitive deficit; neurological pathologies; periodontal disease; fixed or removable dental prosthesis; using muscle relaxant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-22hc4rm	Treatment of pregnancy that occurs in cesarean scar with the aim of preserving the uterus: comparison between two minimally invasive methods	Recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7100	Conservative treatment of Ectopic Pregnancy in Cesarean Scar with Local Injection of Methotrexate guided by Transvaginal Ultrasonography versus Chemoembolization via Utterine Artery: a prospective randomized multicentric study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Escola Paulista de Medicina da Universidade Federal de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-22hc4rm	<NULL>	18 years of age or older; Hemodynamic stability, defined as diastolic blood pressure greater than or equal to 60 mmHg and systolic blood pressure  greater than or equal to 90 mmHg, heart rate less than 100 bpm, and capillary refill time less than or equal to 3 seconds; Gestational age less than 12 weeks; Intact gestational sac in topography of the cesarean scar with embryo with heartbeat; Absence of signs of peritonism; Pregnancy in the exogenous cesarean section scar (COS-1); Myometrial mantle less than 5mm; Desire for a future pregnancy or not wanting to have a hysterectomy; Ease of returning to the hospital if necessary; Signed consent form	Hemoglobin less than 10 g/dl; Leukopenia (leukocytes less than 2,000 cells/mm3); Thrombocytopenia (platelets less than 100,000/mm3); Immunodeficiency, defined by the use of immunosuppressive drugs such as corticoids; Allergy to methotrexate; Current chronic lung disease, such as chronic obstructive pulmonary disease; Liver transaminases above the maximum reference value; Creatinine above the maximum reference value; Breastfeeding; Refusal to receive blood transfusion; Inability to continue the follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-4zjkzv7	Salivary fluoride following toothbrushing in the oral cavity and prevention of dental caries with the use of brazilian red propolis toothing	Not yet recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7101	Fluoride concentration in the oral cavity and prevention of dental caries using Brazilian red propolis dentifrice: randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-10-10	Departamento de Farmácia - Universidade Federal do Ceará	Departamento de Farmácia - Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4zjkzv7	<NULL>	Individuals with orthodontic braces; aged between 8 - 18 years;both genders; individuals with visible plaque; individuals with at least 20 teeth; individuals with no caries lesions	Pregnant women; allergy history; systemic diseases; use of professional fluorides in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-4rfj65s	Physical Exercise improves the minds of the elderly	Recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7102	Effect of Exercise intensity variation on cognitive function in the elderly	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade de São Paulo - USP	Universidade de São Paulo - USP	https://ensaiosclinicos.gov.br/rg/RBR-4rfj65s	<NULL>	Be at least 65 years old; be male or female; do more than 150 minutes of moderate physical activity per week	Limitation to physical exercise; suffering from cardiovascular, metabolic and  or neurodegenerative diseases; use of drugs that affect the nervous system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-10xsbmmb	Effectiveness of Exercise and Education via Telehealth in Patients with Back Pain	Not yet recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7103	Efficacy and equity of exercise combined with education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2025-08-21	Universidade Federal dos Vales de Jequitinhonha e Mucuri	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10xsbmmb	<NULL>	Patients of both genres; over the age of 18; who have had non-specific low back pain for at least 3 months; disability scores of 4 out of 24 points or more on the Roland Morris Disability Questionnaire; and pain intensity scores of 3 out of 10 points or more on an 11 point Numerical Pain Scale; able to read and understand Portuguese; and with internet access	Suspected or confirmed severe spinal pathology (fracture, metastatic, inflammatory or infectious diseases of the spine, cauda equina syndrome/generalized neurological disorder); radiculopathy, grade 2 affected strength, reflex, or sensation to the same nerve root; previous history of spine surgery in the last 12 months; scheduled for major surgery during the study or follow up period; pregnancy; and contraindications to exercise listed in the American College of Sports Medicine guidelines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-4dh99pj	Transcranial direct current stimulation associated with physical exercise in smokers on craving	Data analysis completed	Intervention	2024-06-26	<NULL>	<NULL>	7104	Effects of transcranial direct current stimulation on craving in the cortex prefrontal associated with physical exercise in smokers.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-14	Universidade Federal de Alagoas	Universidade Estadual de Ciências da Saúde de Alagoas - UNCISAL	https://ensaiosclinicos.gov.br/rg/RBR-4dh99pj	<NULL>	Being male or female; being addicted to nicotine for more than 2 years; be between 25 and 55 years old	Substance abuse or dependence other than nicotine dependence; diagnosis of mental disorder, epilepsy, seizures, delirium tremens, chronic obstructive pulmonary disease; use of psychotropic medication; being in treatment to stop smoking; have any contraindication to electrical brain stimulation procedures, such as electronic implants or metal implants in the head; being in a gestational state; present physical and/or physiological problems that interfere with participation in a moderate-intensity physical exercise program; present moderate or high risk for physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-10fwqmfy	Effects of physical training in aquatic and land environment on type 2 diabetes control	Recruiting	Intervention	2024-06-26	<NULL>	<NULL>	7106	Physical training in different environments, aquatic and land, in the control of Type 2 Diabetes: ALED - Aquatic and Land Exercise for Diabetes - a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-17	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10fwqmfy	<NULL>	The sample will consist of adults and elderly people with type 2 diabetes (T2D), of both sexes, aged between 45 and 80 years. Individuals diagnosed with T2D, through laboratory tests and/or use of hypoglycemic medications, will participate in the sample, following the eligibility criteria: HbA1c levels between 6,5 - 10%, not using exogenous insulin, exempt from regular physical exercise (regular practice of exercise will be defined as performing any type of physical training for at least 20 minutes on two or more days of the week) for at least three months, absence of uncontrolled hypertension, absence of autonomic neuropathy, absence of severe peripheral neuropathy, absence of retinopathy proliferative and severe non-proliferative, absence of uncompensated heart failure, absence of peripheral amputation, absence of chronic renal failure and absence of joint or muscular impairments that prevent physical exercise and body mass index (BMI) ≤ 40 kg/m².	Individuals without confirmed type 2 diabetes, under 45 years of age or over 80 years of age, using exogenous insulin, who are regularly practicing physical exercise, with chronic complications that limit the performance of exercises safely.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-9w679s7	Effect of Surf Therapy on psysiology responses in individuals with symptoms of Depression and Anxiety	Recruitment completed	Intervention	2024-06-25	<NULL>	<NULL>	7094	Effect of Surf Therapy on psychophysiological responses in individuals with symptoms of Depression and Anxiety: A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-13	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9w679s7	<NULL>	Inclusion criteria are adults over 18 years old; with symptoms of depression and anxiety; possess sports equipment (sports clothes and sneakers)	Exclusion criteria are uncontrolled chronic diseases; use of controlled medications; disabling physical or clinical condition; previous contact with the modality; professional surfers and attendance rate of less than 70% of scheduled practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-2gqyfgk	Exploring the impact of art therapy workshops on socially vulnerable women: a study on jewelry making	Recruiting	Intervention	2024-06-25	<NULL>	<NULL>	7095	Effects of art therapy: (adornment workshop) in women in social vulnerability	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-03	Centro de Ciências da Saúde - Universidade Federal do Espírito Santo	Centro de Ciências da Saúde - Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-2gqyfgk	<NULL>	Socially vulnerable women undergoing treatment at the Terra Vermelha Health Unit; aged between 18 and 55 years; who attend the Terra Vermelha Health Unit in the municipality of Vila Velha - ES	Socially vulnerable women undergoing treatment at the Terra Vermelha Health Unit in the municipality of Vila Velha - ES, who have physical limitations that prevent them from carrying out the activities proposed by the workshop and refuse to do so	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-77npcd8	Effects of rehabilitation using Nintendo Wii® combined with conventional exercises for upper limbs and cognition in patients with Multiple Sclerosis	Recruiting	Intervention	2024-06-25	<NULL>	<NULL>	7096	Effects of Nintendo Wii® training combined with conventional training on upper limb performance and cognition in patients with Multiple Sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade de Brasília	Secretaria de saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-77npcd8	<NULL>	Inclusion criteria will be age under 75 and over 18 years old; diagnosis of Multiple Sclerosis confirmed by a neurologist according to the McDonald criteria, with more than two years of evolution; a score between 3.5 and 6.5 on the Expanded Kurtzke Disability Status Scale (EDSS); no outbreaks in the last 6 months, before the start of the study; presence of mild to moderate cognitive impairment with a minimum score of 18 points on the Montreal Cognitive Assessment; absence of depression, considering the Beck Depression Inventory test, with a score of up to 13 points.	Exclusion criteria will be the presence of illnesses such as psychiatric, other neurological diseases or musculoskeletal disorders that may impede training; be using a course of steroids, whether orally or intravenously, in the last six months prior to the evaluation; be undergoing treatment with botulinum toxin on the date the clinical trial begins or in the six months before the start of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-10sj4tkp	Evaluation of enamel smoothness following Bracket Removal and Retention Resin for Orthodontic Aligners: a human study	Recruitment completed	Intervention	2024-06-25	<NULL>	<NULL>	7097	Assessment of enamel surface roughness following Removal of Orthodontic Brackets and Attachments: an in vivo study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-05	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-10sj4tkp	<NULL>	Individuals over 18 years old; good oral and general health; not currently undergoing orthodontic treatment; presence of all permanent teeth up to erupted first molars; absence of carious lesions or restorations on the buccal surface of the teeth; male or female genders	Pregnant women; diabetics; history of dental trauma; bruxism; clinically visible cracks in the teeth; absence of space for bracket bonding on the teeth; Remnant Adhesive Index equal to 0	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-2dydyv3	The efficacy of subcostal transversus abdominis plane block as part of multimodal analgesia in the control of postoperative pain in laparoscopic gastric reduction surgery	Recruiting	Intervention	2024-06-25	<NULL>	<NULL>	7279	Efficacy of subcostal transversus abdominis plane block (STAP) as part of multimodal analgesia in the control of postoperative pain in videolaparoscopic bariatric surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-10	Instituto de Pós  Graduação Médica Carlos Chagas	Instituto de Pós  Graduação Médica Carlos Chagas	https://ensaiosclinicos.gov.br/rg/RBR-2dydyv3	<NULL>	Age of 18 years old or older; with an indication for laparoscopic surgical treatment for morbid obesity	Surgeries that needed to be converted to an open technique will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:15
RBR-2258hp5	The effectiveness of topical Estradiol, Vaginal Dilators or a combination of both in preventing vaginal stenosis after Radiotherapy for the treatment of cervical cancer	Not yet recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7086	Randomized clinical trial with topical use of Estradiol, Vaginal Dilator and the combination of both in the prevention of vaginal stenosis in women with cervical cancer after treatment with Radiotherapy	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2024-10-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2258hp5	<NULL>	Women diagnosed with cervical cancer with disease stage I to IIIC2, who are recommended to undergo pelvic Radiotherapy treatment.	Age under 18 or over 75 years old; use of hormonal therapy in the three months prior to inclusion; previous pelvic radiotherapy treatment; refuse to participate in the study; be under treatment or have been treated for breast or endometrial cancer from the time of inclusion; suspicion of neoplasm or hormone-dependent precursor lesion during study follow-up; personal history of thromboembolism or diagnosis of thrombophilia; current or recent history (less than 6 months) of angina or stroke or myocardial infarction; active liver disease; hypersensitivity to the components of the medications used in the study or the orthosis (dilator); porphyria; neurological diseases disabling the ability to follow study instructions; use of an implanted ferromagnetic defibrillator or pacemaker and cochlear implant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-10mgmj53	Benefits of pilates on the health of women in menopause	Recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7087	Effects of mat pilates training on cardiovascular, anthropometric, and strength responses in women in menopause	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-02	Universidade Federal de Uberlândia	Programa de Pós Graduação em Ciencias da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-10mgmj53	<NULL>	Women aged between 40 and 70 years old; present a pre-existing medical certificate proving that they are able to engage in physical activities; do not have physical problems or cardiovascular complications that prevent the practice of physical exercises; do not have a history of stroke or acute myocardial infarction; are non-smokers; do not have a diagnosis of diabetes mellitus; do not have renal pathologies; do not use medications that interfere with lipid metabolism	Training attendance frequency lower than 85%; failure to perform tests in the pre and post intervention periods; injuries of any nature related or unrelated to the project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-8m8754y	Comparison of the success of two antibiotic pastes used in root canal treatment without instrumentation	Not yet recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7088	Evaluation of the sucess rate of two antibiotic pastes used in lesion sterilization and tissue repair: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8m8754y	<NULL>	Children aged 3 to 11 years; no distinction between the sexes; with at least one deciduous molar diagnosed with irreversible pulpitis or pulp necrosis and internal or external resorption; sufficient tooth structure to allow absolute isolation of the operative field and rehabilitation with a stainless steel crown	Children who present any systemic alteration; history of allergic reaction to the components of the pastes to be studied; and have used antibiotics in the last three months from the date of the exam; patients with systemic manifestations (fever and extra-oral abscess) resulting from the infectious process of dental origin or teeth that present obliteration of the pulp canal; impairment of the bone crypt of the permanent tooth; coronary destruction that makes absolute isolation with a rubber dam and/or rehabilitation with a stainless steel crown impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-7tc89xr	Treatment to control Bruxism in adolescent athletes	Recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7089	Effectiveness of two techniques for the management of Bruxism in adolescent athletes: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-05	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7tc89xr	<NULL>	Soccer players aged 10-19 years; of both sexes; with definite awake bruxism or possible or probable sleep bruxism associated with a report of orofacial pain or headache	Adolescents Teenagers with a cognitive and/or neurological disorder or syndrome that makes it impossible to complete the questionnaire. Teenagers who utilize an occlusal splint for the management of bruxism and/or temporomandibular dysfunction or any other treatment for orofacial pain in the last twelve months. Teenagers who have used any medications that may affect motor behavior in the three days leading up to the intervention. Adolescents in use of braces	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-3zzqsfh	Effectiveness of Blue Led to treat Vaginal Candidiasis: randomized controlled trial	Recruiting	Intervention	2024-06-24	<NULL>	<NULL>	7090	Effect of blue led in the treatment of Recurring Vaginal Candidíasis: randomized controlled trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-06-03	Universidade Federal do Delta do Parnaíba UFDPAR	Universidade Federal do Delta do Parnaíba UFDPAR	https://ensaiosclinicos.gov.br/rg/RBR-3zzqsfh	<NULL>	The research will include women; aged between 18 e 40 years; residing in the Coastal Plain; with a proven medical diagnosis of recurrent vaginal candidiasis;  who have steady partners; are not pregnant or in menopause;  are not immunocompromised patients or undergoing oncological treatment; are not undergoing use of metronidazole or other medication that may interfere with the vaginal microflora; do not present lesions in the Pap smear; and have good cognitive and verbal conditions, and who agree to participate in the research, after reading, understanding and signing the Free and Consent Form Clarified - TCLE	Volunteers will be excluded from the research if they have infections of other types; are treated for candidiasis with other modalities at the time of the research; if their partners do not undergo the associated treatment;  if they request to withdraw from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-38gcwz9	Collagen Matrix vs. Connective Tissue Graft for peri-implant soft tissue augmentation	Data analysis completed	Intervention	2024-06-24	<NULL>	<NULL>	7091	Stability of subepithelial Connective Tissue Graft or volumetrically stable Collagen Matrix for ridge volume augmentation: split-mouth randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-15	FAESA-Centro Universitário Espíritosantense	FAESA-Centro Universitário Espíritosantense	https://ensaiosclinicos.gov.br/rg/RBR-38gcwz9	<NULL>	Good oral hygiene with visible plaque index less than 20%; age higher or equal to 18 years; both genders; sufficient tissue availability to harvest an autogenous soft tissue graft from the palate with 12 mm width, 8 mm height, and 2 mm of thickness; soft tissue at the implant site with a thickness inferior to 2 mm; an implant installed for at least 3 months in both sides of the posterior mandible; need for reopening procedure in the implants	Systemic alterations; presence of inflammation or infection involving the regions where the surgical procedures were performed; bone pathology in the implant site; smoking; excessive use of alcohol; drug addiction; diabetes; pregnancy or desire to become pregnant in the next year; history of radiotherapy treatment in the head and neck region, and people who take medications that may interfere with bone remodeling or who have pathologies that affect bone metabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-8dz9zvq	Tooth sensitivity in different dental arches after in-office dental whitening	Data analysis completed	Intervention	2024-06-24	<NULL>	<NULL>	7092	Tooth sensitivity of in-office dental whitening in different arches: a randomized clinical trial	<NULL>	n/a, n/a, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8dz9zvq	<NULL>	Patients at least 18 years old; both genders; with good oral and general health; have their maxillary anterior teeth free from restorations, carious lesions, gingival recessions or periodontal disease; canines with color A2 or darker according to the Classical Vita scale (Vita Zahnfabrik, BadSäckingen, Germany); to agree with the free and informed consent form	Previous dental whitening; previous tooth sensitivity; pregnant or breastfeeding women; severe tooth darkening (tetracycline staining; fluorosis or endodontics); previous dental restorations; previous endodontic treatment; visible cracks; dentures or orthodontic appliances; oral pathologies; bruxism; smokers; patients with gastric, cardiac, renal or hepatic problems; diabetics; hypertensive patients; continuous use of analgesic and anti-inflammatory medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-9d94bxv	Effect of the type of loading of mandibular overdentures retained by narrow diameter implants produced by additive manufacturing: randomized clinical trial	Recruiting	Intervention	2024-06-21	<NULL>	<NULL>	7083	Effect of the type of loading of mandibular overdentures retained by narrow diameter implants produced by additive manufacturing: randomized clinical trial to analyze the clinical, immuno-inflammatory, functional impact and quality of life indicators	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-11	Faculdade de Odontologia da Universidade Federal de Pelotas/RS	M3 Health Industria e Comercio de Produtos Medicos, Odontologicos e Correlatos S.a.	https://ensaiosclinicos.gov.br/rg/RBR-9d94bxv	<NULL>	Patients of both sexes; in a balanced number without age criteria; no self reported systemic health problems; do not use any medication in the last 3 months that affects the immune response; bone quality without the need for local bone grafting; availability to attend Faculty of Dentistry at the Federal University of Pelotas	Patients who smoke; severe diabetes; blood disorders; hemorrhagic diastasis; drug-induced anticoagulation; rheumatoid arthritis; osteogenesis imperfecta; HIV; use of immunosuppressive medications; history of radiotherapy to the head or neck region, history of previous oral implant insertion; patients who have undergone treatment with bisphosphonates in the last 12 months; if female, not pregnant or lactating; with constant use or with a medical history marked by chronic use of analgesics; anti-inflammatories and psychotropic drugs; need for bone grafting at the implant site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-10rssrtj	How to create an in-app cardiopulmonary rehabilitation program and improve health and well-being	Recruiting	Intervention	2024-06-21	<NULL>	<NULL>	7084	Creation of a Model of Cardiovascular Rehabilitation program for e-Health and impact on cardiorespiratory capacity and quality of life	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-20	Universidade de Brasília	Faculdade de Ceilândia da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-10rssrtj	<NULL>	Diagnosis of heart failure (CVD), with at least 6 months of diagnosis, confirmed through ultrasound evaluation and prior clinical examination, in Functional Class II and III according to the New York Heart Association (NYHA). Patients with a clinical diagnosis of long COVID.  Clinically stable for at least 1 month. Age over 45 years old. Both genders.  Able to climb steps without assistance. With access to a smartphone with internet	Complex ventricular arrhythmias. Patients with dysfunctional dyspnea. Patients with angina Previous severe pulmonary or pleural disease. Severe anemia. Diabetes mellitus and decompensated metabolic diseases. Orthopedic disease, peripheral vascular insufficiency or previous neurological disease that impairs the ability to perform the exercises. Cognitive impairment declared by the patient or guardian	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-8km9qs7	Acupuncture for the treatment of anxiety among nursing professionals during the fight against Covid-19	Recruitment completed	Intervention	2024-06-20	<NULL>	<NULL>	7078	Innovation in supporting nursing professionals in coping with Covid-19 through Acupuncture	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-27	Universidade de São Paulo	Universidade Federal Do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8km9qs7	<NULL>	Nursing staff (nurse, nursing technician or nursing assistant) from the urgency and emergency unit or sector that cares for patients with suspected or confirmed Covid-19. Working professionals, allocated to the sector studied. Health professionals who present some level of anxiety, according to the instrument to be applied previously	People who show signs or symptoms of COVID 19 at the time of data collection or intervention. People who leave the selected sector or are dismissed from the institution during data collection. Those who did not want to answer the mandatory questions for the study. Those who miss two sessions in a row or miss without justification	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-3x35jsg	Food advisory by cellphone messages in pregnancy Diabetes	Recruitment completed	Intervention	2024-06-20	<NULL>	<NULL>	7079	Nutritional guidance by digital media to glycemic control for women with Gestational Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-02	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-3x35jsg	<NULL>	Gestational diabetes mellitus according to the International Association Diabetes Pregnancy Study Group criteria; gestation between 24 and 34 weeks at the time of entry into the study; anticipated follow-up in the service for at least 4 weeks; single gestation with a live fetus; personal mobile phone; literate patient capable of using the WhatsApp application	Women who were unable to recall consumed food; pregnant individuals prescribed medication at the first appointment; patients with digestive system pathologies; a history of any type of bariatric surgery; or those who discontinued follow-up in the service in less than 4 weeks were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-2xjfkk8	Effect of combination diuretics in patients with acutely decompensated Heart Failure and Acute Kidney Injury: a randomized controlled clinical trial	Not yet recruiting	Intervention	2024-06-20	<NULL>	<NULL>	7080	Effect of combined diuretic therapy in patients with acutely decompensated Heart Failure and Acute Kidney Injury: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	Faculdade de Medicina de Botucatu da Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2xjfkk8	<NULL>	Patients of both sexes will be included in the study; older than 18 years; with a previous clinical diagnosis of heart failure; in daily home use of oral loop diuretic (furosemide ≥ 80 mg and ≤240 mg); with clinical signs of volume overload (edema, ascites, pleural effusion or pulmonary congestion); Acute Kidney Injury KDIGO 1 and 2 admitted to the Clinical Emergency Room at the Referred Emergency Room of Hospital das Clinicas de Botucatu	Exclusion criteria will be use of vasoactive drugs, systolic blood pressure less than 90 mmHg; stage 5 chronic kidney disease or KDIGO 3 Acute Kidney Injury on admission; presence of hemodynamically significant arrhythmias; hypokalemia and hyponatremia on admission; inability to comply with planned study procedures or refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-6xhtgj8	Effects of exergame physiotherapy on clinical-functional outcomes, hemodynamic parameters and epigenetic markers in sedentary hypertensive elderly women	Not yet recruiting	Intervention	2024-06-20	<NULL>	<NULL>	7082	Effects of kinesiotherapy intervention with exergame on clinical-functional outcomes, hemodynamic parameters and epigenetic markers in sedentary hypertensive elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-15	Universidade de Passo Fundo	Universidade Regional Integrada do Alto Uruguai e das Missões	https://ensaiosclinicos.gov.br/rg/RBR-6xhtgj8	<NULL>	Being female. Be aged 60 or over. Have the ability to walk. Be sedentary according to the World Health Organization  WHO 2018 classification  practicing less than 150 minutes of moderate physical exercise per week. Have a previous diagnosis of hypertension, have been using antihypertensive medication for at least three months and are not in a hypertensive crisis Systolic Blood Pressure  SBP maior que 180 milímetros de mercúrio mmHg and Diastolic Blood Pressure  DBP maior que 120 milímetros de mercúrio mmHg. Present a preserved cognitive aspect, according to the results of the Montreal Cognitive Assessment - MoCA  above 26 points. Participants who do not reach the minimum score will normally participate in the study, but will not be included in the data analysis	Inability to communicate with investigators. Present a high risk of deep vein thrombosis. Grade II and III obesity Body mass index BMI≥35 kg/m2. Participants who do not achieve 75% attendance at meetings. Patients with a cardiac pacemaker. Present depressive symptoms (above 6 points) according to the results of the geriatric depression scale (GDS-15). Have a previous diagnosis of oncological, rheumatological, cardiovascular diseases (except SAH), kidney disease resulting from Systemic Arterial Hypertension - SAH or with cardiovascular, neurological, psychiatric and/or cognitive, immunological and hematological repercussions. Patient on continuous use of hypoglycemic medications. Patients with reduced mobility (range of movement)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-2n2g2p5	Clinical evaluation of a chemical active composite in atraumatic restorative treatment in primary teeth: randomized, double-blind clinical trial	Not yet recruiting	Intervention	2024-06-20	<NULL>	<NULL>	7534	Clinical evaluation of a self-polymerizing composite in atraumatic restorative treatment in primary teeth: randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-2n2g2p5	<NULL>	Patients with one class II cavities  in deciduous molars; healthy and cooperative patients; patients between 4 and 8 years old; be male or female	Patients with systemic diseases; patients with erosion, bruxism and incisal wear; use of orthodontic appliances; allergy to the materials used	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-10gz53gy	Effects of supplementing people with natural products on improving blood parameters and immune system	Recruitment completed	Intervention	2024-06-19	<NULL>	<NULL>	7074	Development of a powder preparation containing yeast cell wall immunomodulatory molecules, turmeric, cinnamon and whey protein isolate added to probiotic culture and its effects on body mass, lipid profile and antibody levels in adult individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-01-11	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-10gz53gy	<NULL>	Being male; age between 25 and 45 years; non-drinkers; non-smokers; do not practice regular physical exercise; not regular consumers of cinnamon, turmeric and probiotic products; have an abdominal circumference equal to or greater than 90 (± 1 cm)	Have an allergy; intolerance to ingredients; or other type of restriction (chronic illness, medication use and acute infection)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-7bcnt96	Short-term effects of robotic physiotherapy therapy on muscle structure and function, physical capacity and muscle activation	Recruiting	Intervention	2024-06-19	<NULL>	<NULL>	7075	Short-term effects of fes-cycling therapy on muscle structure and function, functional capacity and electromyographic behavior	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-03-18	Hospital Universitário Lauro Wanderley	Hospital Universitário Lauro Wanderley	https://ensaiosclinicos.gov.br/rg/RBR-7bcnt96	<NULL>	Patients of both sexes; with clinical signs of muscle weakness; report of loss of strength; gait or balance deficit due to weakness; bed or wheelchair restriction	Clinical conditions that do not allow FES-cycling therapy to be performed; hemodynamic instability; resting tachycardia; oxygen saturation &lt;90% even under oxygen therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-4m4p248	Increased strength training volume and blood flow restriction on muscle mass gains in well-trained postmenopausal women	Not yet recruiting	Intervention	2024-06-19	<NULL>	<NULL>	7076	The effect of increased strength training volume and blood flow restriction on muscle mass gains in well-trained postmenopausal women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-30	Pró Reitoria de Pesquisa da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-4m4p248	<NULL>	Healthy volunteers; postmenopausal; aged between 47 and 80 years; non-smokers or drinkers; non-vegetarians; well-trained in strength training	Volunteers with musculoskeletal, thromboembolic, and gastrointestinal diseases; a history of cardiovascular or infectious diseases; or the presence of varicose veins in the legs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-63f8mpz	Asymmetric Radioelectric Converter - REAC protocols in conditions of sleep disorders	Terminated	Intervention	2024-06-18	<NULL>	<NULL>	7073	Asymmetric Radioelectric Converter Protocols - REAC in disturbance conditions of Sleep	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal do Amapá - UNIFAP	Universidade Federal do Amapá - UNIFAP	https://ensaiosclinicos.gov.br/rg/RBR-63f8mpz	<NULL>	Individuals with self-perceived poor sleep quality; age range of 18 to 60 years; both sexes	Participants with severe psychiatric disorders or cognitive impairment; participants using a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-4kcd92s	Does the positioning and design of attachments affect tooth movement in the in-house aligner system? A randomized clinical trial	Recruitment completed	Intervention	2024-06-17	<NULL>	<NULL>	7071	Biomechanic aspects of orthodontic attachments in in-house aligners: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-16	Pontifícia Universidade Católica de Minas Gerais - PUCMG	Pontifícia Universidade Católica de Minas Gerais - PUCMG	https://ensaiosclinicos.gov.br/rg/RBR-4kcd92s	<NULL>	Previous preventive orthodontic treatment carried out at PUC Minas and the need for the corrective orthodontic phase to complete the case; need for corrective orthodontic treatment with mild to moderate discrepancies; permanent denture completely erupted, with the permanent second molars being in the mouth or not; absence of systemic diseases or regular use of medications that could interfere with average growth and orthodontic movement; both genders	Patients who do not have permanent dentures; who have severe malocclusion; who have systemic diseases that may influence orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-98rr4sm	Clinical comparison between the use of a giomer technology composite resin and resin-modified glass ionomer cement in restorations in posterior primary teeth: a randomized clinical trial	Not yet recruiting	Intervention	2024-06-17	<NULL>	<NULL>	7072	Comparison of clinical success between giomer resin composite restorations and resin-modified glass-ionomer cement in primary molars: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-10	Universidade Federal de Minas Gerais - UFMG	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-98rr4sm	<NULL>	Children aging between 4 and 8 years; both genders; children presenting good health conditions; children whose parents or legal guardians accept and sign the consent form; children with at least one occlusal proximal caries in primary molars, only occlusal-proximal surfaces with caries with dentin involvement	Severe behavioral issues; presence of fistula or abscess near the selected tooth; presence of pulp exposure in the selected tooth; presence of mobility in the selected tooth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-86kcy37	Assessment of praziquantel medication for children living in areas where schistosomiasis is common in Bahia and Sergipe	Recruiting	Intervention	2024-06-14	<NULL>	<NULL>	7068	Evaluation of the efficacy and safety of pediatric praziquantel in children residing in endemic areas of Bahia and Sergipe	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2024-12-09	Centro de Pesquisas Gonçalo Moniz - Fundação Oswaldo Cruz - BA	Instituto Gonçalo Moniz (IGM) - Fundação Oswaldo Cruz (Fiocruz-BA)	https://ensaiosclinicos.gov.br/rg/RBR-86kcy37	<NULL>	Age between 3 months and 6 years; both sexes; presence of at least one *Schistosoma mansoni* egg detected by the parasitological methods used; minimum body weight of 8 kg for children aged 2 to 6 years and 5 kg for children under 2 years of age	Presence of conditions that contraindicate the use of praziquantel at the physician’s discretion, such as viral or bacterial infections, diarrhea, gastroenteritis, among others; prior treatment with praziquantel within the past 6 months; concomitant treatment with other drugs that may affect praziquantel metabolism, such as certain antiepileptics, glucocorticoids, chloroquine, rifampicin, or cimetidine; participants with hepatosplenic schistosomiasis; participants with body temperature above 37.5 °C; for infants and breastfeeding children, maternal treatment with praziquantel within the 3 days preceding the administration of pediatric praziquantel	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:03
RBR-4h25ytk	Comparison of balanced solutions in abdominal oncological surgery: a pragmatic, randomized, controlled, double-blind study between Plasmafundin and Ringer&apos;s Lactate	Recruitment completed	Intervention	2024-06-14	<NULL>	<NULL>	7069	Assessment of the impact of two perioperative volume replacement solutions in oncological abdominal surgery on the occurrence of metabolic acidosis: comparison between Plasmafunfin and Ringer Lactate	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-06-01	Fundação Faculdade de Medicina	Instituto do Câncer do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4h25ytk	<NULL>	Major elective oncological abdominal surgeries, expected to last more than 4 hours and requiring a post-operative ICU; age 18 or over; understanding and signing the consent form by the patient or guardian; both genders	Urgent or emergency surgery; severe sepsis or septic shock; patients under 18 years of age; chronic obstructive pulmonary disease; decompensated diabetes mellitus; Body Mass Index (BMI) above 35 kg/m2; left ventricular ejection fraction less than 35%; chronic renal failure on dialysis; participation in another interventional study that has an influence on the intervention of this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-2j778gq	Assessing depression, anxiety, stress, loneliness, drug use and communication skills in college students to develop interventions that help them	Recruitment completed	Intervention	2024-06-14	<NULL>	<NULL>	7070	Emotional symptoms, loneliness, drug use, assertiveness in university students: from evaluation to intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-2j778gq	<NULL>	Being at leats 18 years-old; both genders; being enroled at a Brazillian institution in an undergraduate course	Presenting psychotic symptoms; excessive use of drugs; and/or having suicidal or self-harming ideation or behavior	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-3cf3zj3	Effect of Buzzy® cooling and vibration on pain perception and success of peripheral venipuncture in hospitalized children clinical trial	Recruiting	Intervention	2024-06-13	<NULL>	<NULL>	7066	Effect of vibration and cryotherapy with Buzzy® on pain perception and success of peripheral intravenous catheterization in hospitalized children parallel and open clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal de São Paulo	Laboratório de Estudos e Pesquisas em Inovação e Segurança no Cuidado em Saúde - Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-3cf3zj3	<NULL>	Age between 4 to 12 years incomplete; elective indication for peripheral intravenous catheterization with catheter over needle; peripheral intravenous catheterization performed regardless of shift; stable clinical or surgical conditions; first peripheral intravenous catheterization performed at the hospital	Being hospitalized in wards that require the use of some specific contact or respiratory precautionary measure; be in the preoperative period that requires peripheral intravenous catheterization immediately before being transferred to the operating room; have a medical request to collect a blood sample for laboratory tests during the peripheral intravenous catheterization; having a skin lesion near the catheter insertion site, which will prevent Buzzy from positioning; Having previous nerve damage in areas close to the region to be catheterized or any report of limited sensitivity in the extremity listed for insertion of the intravenous catheter; Have peripheral neuropathy; being diagnosed with a disease associated with hypersensitivity to cold such as Raynaud&apos;s Syndrome or sickle cell disease; having used topical, enteral or parenteral analgesics between four to eight hours before catheterization; presence of cognitive impairment or inability to verbally report pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-4pkhf4b	Effect of Therapeutic Laser Compared to Standard Care on Pain and Inflammation in Postoperative Cesarean Section: Comparative Study	Not yet recruiting	Intervention	2024-06-13	<NULL>	<NULL>	7067	Efficacy of Low-Level Laser compared to usual care on pain Intensity and inflammatory modulation of immediate postoperative cesarean section wound: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-24	Departamento de Fisioterapia da Universidade Federal de Pernambuco - Campus Recife	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4pkhf4b	<NULL>	Participants who are over eighteen years old; participants without any clinical or obstetric complications and who have a score higher than three on the Visual Analog Scale VAS	Participants lacking capacity to consent; postpartum participants who have experienced complications such as hemorrhage; cesarean wound dehiscence; or sepsis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-42xvqrz	Does Combined Non-Invasive Neuromodulation affect cerebral oxygenation and the sympathetic/parasympathetic system in subjects with Depression? Controlled and randomized study	Not yet recruiting	Intervention	2024-06-12	<NULL>	<NULL>	7063	Does Combined Non-Invasive Neuromodulation affect intracranial hemodynamics and sympathetic/parasympathetic neurovegetative tone in subjects with Depressive Disorder? Controlled and randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-30	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-42xvqrz	<NULL>	Participants with mild and moderate depressive disorder; aged between 18 and 45 years; diagnosed and reported by a professional psychiatrist and/or psychologist	Individuals with epilepsy using anticonvulsant medication and/or sleep deprivation; participants with metallic materials implanted in or near the head; participants with cardiac pacemakers or wires (Stents) or with another active device in which the interaction with the electric field may interfere with its functioning; participants with eczema on the head	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-25qdfgq	Efficacy of printed stabilizing splint in Temporomandibular Disorders (TMD) therapy	Recruiting	Intervention	2024-06-12	<NULL>	<NULL>	7064	Effectiveness of printed digital stabilizing occlusal splint obtained through two different techniques, in the treatment of signs and symptoms of temporomandibular disorders: clinical, randomized study with two parallel arms	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-06	Universidade de São Paulo - Faculdade de Odontologia	Universidade de São Paulo - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-25qdfgq	<NULL>	Both sexes; Over 18 years; with signs and symptoms of temporomandibular disorders (TMD) identified by the temporomandibular disorders diagnostic criterion questionnaire (CD/TMD) by a single calibrated evaluator; diagnosed with spreading myofascial pain; local myalgia; referred pain; disc displacement with reduction with painful symptoms; disc displacement without reduction; participants with arthralgia and joint noise (crepitus) must present additional MRI examination of the temporomandibular joint (TMJ) and/or computed tomography of the TMJ at the time of physical assessment	Patients with local osteoarthritis with open lesions such as erosion and subchondral sclerosis in the condyle, disc perforation and systemic osteoarthritis; users of bruxism-inducing medications such as serotonin reuptake inhibitors; presenting an accentuated curve of Spee &gt;2mm with gross interference during disocclusion movements and in the maxillomandibular position; undergoing temporomandibular joint (TMJ) prosthesis surgery; in premature treatment; pregnant women; completely toothless; unimaxillary; unrehabilitated bimaxilla	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:09
RBR-8p38sh3	Use of Auriculotherapy for Urinary Incontinence in adults or elderly people who have undergone genital or urinary surgery	Not yet recruiting	Intervention	2024-06-12	<NULL>	<NULL>	7065	Efficacy of Auriculotherapy for Urinary Incontinence in adults or elderly people undergoing genitourinary surgical procedures: mixed methods study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-8p38sh3	<NULL>	Adults or elderly people will be included; who undergo genitourinary surgery at a university hospital in southern Brazil; who are in the immediate post-operative period (between 24 hours and seven days) or late post-operative period (from the seventh post-operative day); have moderate, severe or very severe urinary incontinence, as classified using the urinary incontinence severity assessment questionnaire – Incontinence Severity Index; and, have preserved cognitive capacity, assessed through the Mini Mental State Examination	People who underwent treatment for urinary tract infections within 30 days of data collection; patients who require the use of an indwelling bladder catheter postoperatively	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-3n32q2k	Association of Periodontitis and Non-Alcoholic Fatty Liver Disease	Recruiting	Intervention	2024-06-11	<NULL>	<NULL>	7061	Association of Periodontitis with the inflammatory state and clinical profile of patients with Non-Alcoholic Fatty Liver Disease	<NULL>	n/a, n/a, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-04	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3n32q2k	<NULL>	Patients from the Hepatology Service of the Clementino Fraga Filho University Hospital diagnosed with non-alcoholic fatty liver disease; both gender	Totally edentulous patients; patients with less than 10 teeth present; smoking patients; patients who have used antibiotic medication in the last six months at baseline, anti-inflammatories or medications potentially inducing gingival hyperplasia (phenytoin, nifedipine and cyclosporine) in the last three months; patients with indication of antibiotic prophylaxis for periodontal clinical approaches; patients undergoing periodontal treatment in the last six months; patients undergoing orthodontic treatment; and patients with any syndrome, except metabolic syndrome; patients who have already used medication that induces hepatic steatosis (e.g. amiodarone, tamoxifen and methotrexate); third molars, residual roots, teeth with non-carious cervical lesion, caries lesion or subgingival restoration, teeth with altered development associated with protective and/or supporting periodontal tissues, teeth involved in local pathological processes, teeth with suspected fracture, teeth with previous or current history of endodontic accident/complication, or even endoperiodontal injury, will not be considered in the periodontal evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-57vfs7m	Impact of nutritional education on nutritional knowledge, food consumption, energy expenditure and body composition in people living with HIV	Recruitment completed	Intervention	2024-06-11	<NULL>	<NULL>	7062	Impact of food and nutrition education on food consumption, nutritional knowledge, energy expenditure and body composition in people living with Hiv	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-22	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-57vfs7m	<NULL>	Individuals with Human Immunodeficiency Virus (HIV); on antiretroviral therapy for at least 6 months; aged between 18 and 50 years; both genders; physically active; smokers and non-smokers	Individuals without Human Immunodeficiency Virus (HIV); Physically inactive or unable to exercise; Under 18 or over 50; Individuals with HIV without antiretroviral therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-289qkjg	The effect of a Cell Phone Application on the Self-care of people with a Stoma in the Intestine	Recruiting	Intervention	2024-06-10	<NULL>	<NULL>	7060	Effectiveness of a Mobile Application in Self-care for people with Intestinal Ostomies	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-17	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-289qkjg	<NULL>	Have an intestinal stoma up to 1 year old; own a smartphone; be 18 years old or over; and does not use other health guidance strategies related to the ostomy, with the exception of conventional ones offered by health service professionals	Illiterate people will be excluded; who have some learning or motor deficit; mental disorder diagnosed in medical records that prevents understanding and handling of the application	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-59xmv6s	Non invasive electrical stimulation of the head combined with physical exercise for individuals with shoulder pain for more than three months	Not yet recruiting	Intervention	2024-06-08	<NULL>	<NULL>	7058	Effects of Transcranial Direct Current Stimulation combined with Physical Exercise on pain and function in individuals with Chronic Shoulder Tendinopathy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-28	Faculdade de Ciências da Saúde do Trairi, Universidade Federal do Rio Grande do Norte - FACISA/UFRN	Faculdade de Ciências da Saúde do Trairi, Universidade Federal do Rio Grande do Norte - FACISA/UFRN	https://ensaiosclinicos.gov.br/rg/RBR-59xmv6s	<NULL>	Men and women who have a clinical and/or imaging diagnosis (ultrasound or magnetic resonance imaging) of shoulder tendinopathy, accompanied by pain for more than three months during resisted abduction and external rotation movements of the shoulder and have shoulder pain; report pain ≥3 on the Numerical Pain Scale; age between 18 and 65 years old; have central pain sensitization according to the Central Sensitization Questionnaire Brazilian Portuguese Central Sensitization Inventory – BP and not present neuropathic pain; not have a neurological deficit that could compromise the follow-up and understanding of interventions; do not use implanted metallic devices, in addition to not being pregnant; not be undergoing any other medication or physiotherapeutic treatment for tendinopathy throughout the study; Individuals with initial pain intensity less than 3 (END &lt; 3) will not be included in the study, to avoid ground effect bias	Individuals with complete rotator cuff tear; report pain and/or irradiation to the spinal region; have other disorders such as frozen shoulder, severe osteoarthritis, fracture and dislocation; those who had a corticosteroid injection in the last 6 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-1024f4qs	Resistance training on hunger, energy intake and sleep in women and men	Terminated	Intervention	2024-06-08	<NULL>	<NULL>	7059	Exercise mediated appetite suppression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-1024f4qs	<NULL>	40 men (20 eutrophic and 20 obese) and 40 women (20 eutrophic and 20 obese); age between 18 and 35 years old; no previous experience in resistance training; absence of physical limitations; no diagnosis of chronic diseases; not communicating maintaining; Stable weight in the last three months	Have an eating or sleeping disorder; presence of scheduled surgeries during the study period; reluctance to sign the free and informed signature form; participation in another study; alcohol or drug abuse; missing any scheduled assessment or testing routine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-3bhkdg2	Supplementation of Angiotensin-(1-7) formulations and their actions on physical performance and repair of muscle damage in recreational athletes and in physically active and sedentary people	Recruiting	Intervention	2024-06-06	<NULL>	<NULL>	7051	Angiotensin formulations-(1-7) its actions on physical performance and injury repair muscular	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-28	Universidade Federal de Ouro Preto	Universidade Federal de Minas Gerais - UFMG/ Departamento de Fisiologia e Biofísica	https://ensaiosclinicos.gov.br/rg/RBR-3bhkdg2	<NULL>	Healthy individuals who have been cycling and boxing for at least 3 years; sedentary individuals; non-smoking; be over 18 years old; use medications such as anti-inflammatories and antibiotics and/or others that could compromise research data; as well as consuming supplements that interfere with physical performance	Do not sign the TCLE of the volunteer&apos;s free will; failure to attend the physical test battery on the scheduled day and time; present some type of illness that compromises data collection; who start using medications such as anti-inflammatories and antibiotics and/or others that could compromise research data; as well as starting to consume supplements that interfere with physical performance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-7nrvmmm	Clinical trial on the incidence of complications related to the insertion of more than one Central Venous Access into the internal jugular vein	Not yet recruiting	Intervention	2024-06-06	<NULL>	<NULL>	7052	Incidence of complications related to multiple Central Venous Access in the internal jugular vein: multicenter randomized non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Hospital Nossa Senhora da Conceição - Grupo Hospitalar Conceição	Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7nrvmmm	<NULL>	Patients over 18 years of age; ASA I to IV; scheduled for heart surgery; vascular surgeries; abdominal surgeries; major thoracic surgeries; liver transplants; lung transplants; with anesthetic planning for the insertion of at least two central venous catheters	Patients with a previous history of central venous thrombosis; or central venous stenosis; patients under 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-6w7vwb3	Effect of traditional 5-Fluorouracil emulsion versus smaller particles of 5-Fluorouracil emulsion in the treatment of skin aged by sun exposure and prone to developing Skin Cancer	Recruitment completed	Intervention	2024-06-06	<NULL>	<NULL>	7054	Effect of classical 5-Fluorouracyl emulsion versus compounded 5-Fluorouracyl emulsion with hydrophilic polymer and high-pressure homogeneization on Field Cancerization and Advanced Photoaging	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2022-01-01	Escola Paulista de Medicina/Universidade Federal de São Paulo - UNIFESP	Escola Paulista de Medicina/Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-6w7vwb3	<NULL>	Male or female; over 50 years; phototypes I to III, according to Fitzpatrick Scale; forearms with clinical diagnosis of severe or advanced photoaging, associated with actinic keratosis; agreement to avoid photoexposure during the period of therapy; ability to understand and strictly respect the guidelines provided; availability for periodic visits	Smokers; including indirect smokers; or former smokers, who stopped smoking for at least two years; topical treatments with tretinoin less than six months and other retinoids, alphahydroxy acids, polyhydroxy acids, betahydroxy acids and ascorbic acid less than three months; treatment with superficial chemical peels; microdermabrasion and fractional lasers less than three months; oral retinoid less than six months; history of hypersensitivity to parabens; infectious or inflammatory dermatoses diagnosed on the arms; previous chemotherapy or radiotherapy treatment; clinical evidence of immunosuppression; presence or history of photodermatosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-2md8855	Effect of Transcranial Neuromodulation (TN) associated with a program based on meditation on the pain of women with Migraine	Not yet recruiting	Intervention	2024-06-06	<NULL>	<NULL>	7055	Effect of Transcranial Magnetic Stimulation (TMS) associated with a program based on Mindfulness meditation on the pain of women with Migraine: a feasibility study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-20	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	Centro de Ciências da Saúde da Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-2md8855	<NULL>	Women (cis or trans). Aged between 18 and 65 years old. Present a diagnosis of Migraine according to the criteria of The International Classification of Headache Disorders (ICHD-3) 2018, for more than 3 months: at least five attacks meeting criteria from B to D; headache attacks lasting 4-72 hours (without treatment or with ineffective treatment); the headache has at least two of the following characteristics: unilateral location, pulsatile character, moderate or severe pain intensity, exacerbated by or causing the individual to avoid routine physical activities (for example: walking or climbing stairs); during headache, at least one of the following: nausea and/or vomiting, and photophobia and phonophobia, not better explained by another ICHD-3 diagnosis	Participants who are at a peak of cardiovascular disease or have severe cardiopulmonary disease. With sequelae of neurological diseases. Use walking aids. With visual and hearing impairments. With amputations of lower and upper limbs. With rheumatic diseases in the acute phase. Cancer. Epilepsy. Fractures of the skull, neck or rib cage. Severe osteoporosis. People with a pacemaker or implantable cardioverter defibrillator, epilepsy or who underwent surgery less than 1 year ago. Pregnant or breastfeeding women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-475mc4q	Evaluation of a gel containing green tea and hyaluronic acid after periodontal access flap surgery: randomized clinical trial	Recruitment completed	Intervention	2024-06-06	<NULL>	<NULL>	7056	Evaluation of a gel containing the active ingredient of green tea and hyaluronic acid in post-surgical tissue repair: a randomized clinical study in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-475mc4q	<NULL>	Patients of both sexes; should have completed periodontal therapy related to the cause more than a month ago and still have sites with 2 or more adjacent teeth presenting pockets with a probing depth greater than or equal to 5 mm; with bleeding on probing and/or suppuration; and also good standards of oral hygiene (plaque index (PI) ≤ 25% and bleeding on probing index (IBP) ≤ 20%)	Patients should not have systemic conditions that could interfere with post-surgical repair, such as diabetes; they should not use medications that affect the gums and/or oral mucosa (phenytoin and other antiepileptic agents; cyclosporine; calcium channel blocking agents); they could not be smokers; pregnant or breastfeeding patients; patients who had a history of allergy to any of the components to be used in the present study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-7wrfjn8	Comparison of the motor response time of the upper and lower limbs of people with Down Syndrome when performing an activity on the computer	Recruiting	Intervention	2024-06-06	<NULL>	<NULL>	7057	Comparison of the reaction time of the upper and lower limbs of individuals with Down Syndrome during a computational task	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-11	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7wrfjn8	<NULL>	Individuals with a clinical diagnosis of Down Syndrome and individuals with typical development (to make up the Control Group); of both sexes; from eight years of age will be included	Individuals who do not carry out the proposed activities due to lack of understanding or other factors; individuals with an associated diagnosis of Autism Spectrum Disorder (ASD) or Oppositional Defiant Disorder (ODD); in addition to withdrawal during the protocol; children and young people with low vision or blindness and vestibular pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-87wb8x5	Effectiveness of different nutritional treatments for the health care of women with Obesity in Viçosa-MG	Recruitment completed	Intervention	2024-06-05	<NULL>	<NULL>	7047	Evaluation of the effectiveness of nutritional interventions for the health care of women with Obesity in Viçosa-MG	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal de Viçosa	Prefeitura Municipal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-87wb8x5	<NULL>	Women between the ages of 18 and 60; with a BMI greater than or equal to 25 kg/m2; who are not currently engaged in any other method of weight control	The exclusion criteria were: current pharmacological treatment for obesity; have serious medical or psychiatric conditions; insulin-dependent diabetes; be pregnant, breastfeeding or intending to become pregnant during the study period; have untreated hypothyroidism or hyperthyroidism; practicing mindfulness, meditation, yoga or similar practices in the previous 6 months (with formal practice at least once a week); having had any type of bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-78w4k8c	Omega-3 nutrient supplementation and inflammatory and metabolic markers in people with Obesity: a randomized, controlled, double-blind clinical study	Not yet recruiting	Intervention	2024-06-05	<NULL>	<NULL>	7048	Physiological dose DHA supplementation and inflammatory and metabolic markers in people with Obesity: a randomized, controlled, double-blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-25	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-78w4k8c	<NULL>	Female biological sex; male biological sex; age range between 18 and 59 years; BMI equal to or greater than 30 kg /m2 (indicating obesity); sedentary (practicing less than 150 minutes of moderate to vigorous aerobic activity per week)	Unstable weight (2kg in the last 6 months); previous history or evidence of diseases that compromise the absorption of nutrients; cognitive impairment, in a way that compromises the understanding and consequent acceptance of participation in the research; hypertension; pacemaker patients; being in the gestational period or menopause; having an irregular menstrual cycle; smokers; have a food allergy or debilitating disease(s) of the gastrointestinal tract or some type of impairment of nutrient absorption; drug addicts or those with a history of misuse; those who start a diet or a sporting discipline during the study; those who are using or who during the study need to use medication that compromises or biases the results of the study; non-adherence to the proposed treatment (intervention); denial or withdrawal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-653b457	Proteins and salivary metabolites related to gum and bone disease around the teeth and Gestational Diabetes Mellitus during the 3rd trimester of pregnancy	Recruiting	Observational	2024-06-05	<NULL>	<NULL>	7049	Proteins and salivary metabolites related to Periodontitis and Gestational Diabetes Mellitus during the 3rd trimester of pregnancy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-06	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-653b457	<NULL>	Pregnant women who are in the 3rd trimester of pregnancy (from the 27th gestational week); between 18 and 40 years of age; with regular follow-up with the obstetrician; who have already undergone the Oral Glucose Tolerance Test through the Unified Health System between the 24th and 28th week of pregnancy, as recommended by the World Health Organization; and who present adequate cognitive and neuromotor behavior, enabling easy understanding for participation in the research and adequate ability to perform regular oral hygiene	Participants who have systemic arterial hypertension (blood pressure equals to or higher than 140/90 mmHg) diagnosed before or during pregnancy will be excluded from the sample; pre eclampsia; malnutrition (pre-pregnancy Body Mass Index [BMI] lower than 18.50 kg/m2); obesity (pre-pregnancy BMI equals to or higher than 30.00 kg/m2); diagnosed or suspected of being infected with SARS-CoV-2; who require absolute rest for any medical reason; diagnosed with any other systemic disease other than Gestational Diabetes Mellitus; who are using, or who have used at any time during pregnancy, antibiotics or any medication that may interfere with periodontal condition and/or salivary flow (for example, immunosuppressive drugs, anticonvulsants or calcium channel blockers, such as cyclosporine, phenytoin or nifedipine, respectively), with hyposalivation (flow lower than 0.25 ml/min); diagnosed with stage I periodontitis; who have one or more cavitated carious lesions; with multiple tooth loss (more than two teeth per hemiarch); with tooth loss prior to pregnancy due to periodontitis; who are undergoing orthodontic, periodontal treatment or with another dental surgeon with a treatment plan already determined; who have previously undergone surgical periodontal treatment; users of alcohol/tobacco/illegal drugs during pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-5z6dxkr	Comparison between normal diet and special diet for Diabetes in controlling blood sugar level in critically ill patients	Not yet recruiting	Intervention	2024-06-05	<NULL>	<NULL>	7050	Comparison between standard formula and specialized formula for Diabetes in glycemic control in critically ill patients	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2024-06-30	Centro Universitário do Espírito Santo - UNESC	Hospital e Maternidade São José - HMSJ	https://ensaiosclinicos.gov.br/rg/RBR-5z6dxkr	<NULL>	Adult and elderly patients - minumum age 18 years old; on invasive mechanical ventilation; of both sexes; who present hyperglycemia (blood glucose ≥180 mg/dl) in the first 72 hours after hospitalization	Patients already admitted to palliative care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-53qz7zn	Effects of trigger point compression and Cupping Therapy on individuals with neck Pain	Recruiting	Intervention	2024-06-04	<NULL>	<NULL>	7045	Effects of Manual Ischemic Compression and Cupping Therapy on individuals with neck Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal de Santa Catarina	Laboratório de Avaliação e Reabilitação do Aparelho Locomotor	https://ensaiosclinicos.gov.br/rg/RBR-53qz7zn	<NULL>	Women; age between 18 and 40 years; body mass index (BMI) ≤ 35 kg/m²; presence of an active trigger point in the descending trapezius; acute neck pain with onset within 3 months; pain level ≥ 3 on the numerical pain rating scale (NPRS) on the day of the assessment	Any self-reported injury or limitation in the cervical region or shoulder; concomitant treatment for neck or shoulder pain; use of analgesics, anti-inflammatories or muscle relaxants within 48 hours prior to the assessment; any contraindication to cupping; pre-menstrual syndrome (PMS), period of menstruation and pregnancy; signs or history of rheumatological or neuropathic diseases, endocrine or autoimmune disorders and spinal surgery; any event that does not allow the subject to participate throughout the research period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-729hxcd	Organization of meal times and their effects on eating practices and body measurement patterns in physical exercise practitioners as strategies for nutritional care in a medium-sized municipality in the center-west region of brazil	Recruitment completed	Intervention	2024-06-04	<NULL>	<NULL>	7046	Management of the chrononutrition profile and its effects on eating practices and anthropometric patterns in physical exercise practitioners as strategies for nutritional care in a medium-sized municipality in the central-western region of brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-29	Universidade Federal de Catalão	Secretaria Municipal de Esportes e Lazer de Catalão	https://ensaiosclinicos.gov.br/rg/RBR-729hxcd	<NULL>	All genders; enrolled at the gym; aged over 18 and under 60; not undergoing nutritional monitoring; attending the gym more than 3 times a week; having a BMI greater than 25 kg/m2; being mentally and physically fit to take part in the study	Not doing physical activity; not showing up for orientation; not being able to wear a watch; not having a cell phone or the internet	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-6d3mxjw	Effects over time of arm therapy for children with cerebral palsy	Data analysis completed	Intervention	2024-06-03	<NULL>	<NULL>	7039	Long-term effects of constraint-induced movement therapy in the hemiparetic upper limb use in children with cerebral palsy between two and ten years of age	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-01-06	Departamento de Fisioterapia da Universidade Federal de São Carlos	Departamento de Fisioterapia da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6d3mxjw	<NULL>	Have a diagnosis of hemiplegic cerebral palsy; gross motor function level one to three; manual function level one to three; score on the pediatric manual upper limb scale with an average score less than two and a half	Have cognitive or visual impairment; be allergic to the cast material; have behavioral problems that compromise the application of therapy; be undertaking other intensive training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-4t2hqqt	Effect of Calcium Hypochlorite in Endodontic Treatment	Data analysis completed	Intervention	2024-06-03	<NULL>	<NULL>	7040	Effect of Calcium Hypochlorite as an irrigating solution in Endodontic Treatment: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4t2hqqt	<NULL>	Healthy patients; both genders; age between 18 and 60 years;need for endodontic treatment; asymptomatic	Use of antibiotics, anti-inflammatories or analgesics for at least 7 days before the procedures; preoperative pain; teeth with incompletely formed apices; calcified root canals; periodontal probing greater than 3 mm; persistent exudate at the time of filling; immunosuppression or immunocompromised	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-8m9p6ht	Effect of Functional Fitness and Urban Dances on the physical and psychological health of Menopausal Women	Not yet recruiting	Intervention	2024-06-03	<NULL>	<NULL>	7041	Functional Fitness and Urban Dances in the physical and psychological aspects of Menopausal Women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-8m9p6ht	<NULL>	Only menopausal women between 40 and 59 years old who fall into the Menopause Rating Scale; who have serum follicle-stimulating hormone levels greater than or equal to 25 IU/ml; who have not practiced Functional Fitness and Urban Dances in the three months prior to data collection; who refrain from practicing these same types of physical exercise in an environment other than that of the research, during the 12 weeks, however, any other type of physical exercise or physical activity that the participant is already practicing or will carry out throughout the year may be carried out. of this period	Women who do not have menopausal symptoms according to the Menopause Rating Scale cutoff point 1 point; do not abstain from training during the intervention period (12 weeks); those with a history of neurological and musculoskeletal diseases; who have performed aerobic, resistance, or dance training in the three months prior to data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-7pbwhnv	New Moisturizing Cream containing pre- and post-biotics in the skin bacteria of patients with Atopic Dermatitis	Not yet recruiting	Intervention	2024-06-03	<NULL>	<NULL>	7042	New Moisturizing Cream containing pre- and post-biotics in the skin microbiome of patients with Atopic Dermatitis: a pilot study of therapeutic intervention, randomized, prospective, comparative, parallel-group, double-blind, placebo-controlled	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7pbwhnv	<NULL>	Signature of the Informed Consent Form (ICF) and Assent Form before any study procedures; Patients of any gender, aged one to fourteen years old; Clinical diagnosis of mild atopic dermatitis (SCORAD less or equal to 20). Eczematous lesions present in the antecubital fossae	Patients or guardians who do not agree with the study conditions or lack the capacity to understand and strictly follow the received instructions, without availability to attend reassessments, or who refuse to sign the Informed Consent Form (ICF) and Assent Form; non-agreement to sign the Photography Authorization Form will not be a reason for exclusion from the study; Pregnant or lactating women; Moderate and severe atopic dermatitis; Immunosuppression or genodermatoses, such as Netherton syndrome; Chlorine bath in the last week; Use of topical corticosteroids or calcineurin inhibitors in the last two weeks; Use of topical or oral antibiotics in the last thirty days; Use of oral immunosuppressive medications in the last thirty days; Use of immunobiologics in the last sixteen weeks; Use of phototherapy in the last thirty days; Active bacterial, viral, or fungal skin infections; Hypersensitivity to any component of the formulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-6qjxfw2	The experience of a multidisciplinary team in care for Insulin Pump users in the trreatment of Type 1 Diabetes Mellitus in a SUS Outpatient	Recruitment completed	Intervention	2024-06-03	<NULL>	<NULL>	7043	Performance of a specialized team in care for Insulin Pump users in the trreatment of Type 1 Diabetes Mellitus in a SUS Outpatient	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-15	Maria Catarino Simões Pinto	Faculdade de Medicina de Botucatu UNESP	https://ensaiosclinicos.gov.br/rg/RBR-6qjxfw2	<NULL>	Type 1 diabetic patients;Between 15-60 years of age;Monitoring the disease at the Type 1 Diabetes outpatient clinic at the Clinical Hospital Faculty of Medicine of Botucatu endocrinology service;Using an insulin pump prior to the study start date; Agree to participate in the study,and the Free and Informed Consent Form (ICF)	Patients using multiple doses of insulin as a method of Diabetes Mellitus Type 1 treatment; Refusal to Free and Informed Consent Form; Elderly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-5y5pbpr	Effect of acute use of Melatonin on Hemodynamic, Metabolic and Physical Variables during and after Running exercise in different conditions	Not yet recruiting	Intervention	2024-06-03	<NULL>	<NULL>	7044	Effect of acute Melatonin administration on Physiological and Physical Performance Parameters during and after Running in different conditions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de São Carlos - UFSCar	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-5y5pbpr	<NULL>	Men and women aged between 18 and 35; apparently healthy; physically independent; normotensive; non-obese (i.e., Body Mass Index greater than 30 kilograms per square meter and body fat percentage less than 20 percent; not tobacco or alcohol users; moderately active (i.e., greater than or equal to 150 minutes per week of physical activity ); engaged in regular physical training programs.	Subjects who self-report cardiovascular, metabolic diseases, sleep and neuromuscular disorders and/or musculoskeletal injuries; continuous use of dermatological medications and antipyretics and diuretics; have used ergogenic substances (e.g., anabolic androgenic steroids) in the last six months prior to the start of research; skin folds in the regions of interest (front of the thigh and arm) greater than 20 millimeters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-4v36p2h	Clinical predictors of recurrence and malignization of Oral Leukoplakia and Proliferative Verrucous Leukoplakia: a randomized clinical trial	Recruiting	Intervention	2024-06-01	<NULL>	<NULL>	7038	Clinicopathological and digital predictors of recurrence and malignancy of Oral Leukoplakia and Proliferative Verrucous Leukoplakia: a clinical study associated with artificial inteligence	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-18	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4v36p2h	<NULL>	We will select 60 patients diagnosed with oral leukoplakia (OL) and 60 patients with proliferative verrucous leukoplakia (PVL) through biopsy and histological analysis. Only patients presenting with OL and PVL located in any region in the oral cavity will be selected. It is estimated that the participants will be mostly male smokers over 50 years of age for the diagnosis of OL and non-smoking women over 60 years of age for the diagnosis of PVL.	We will excluded patients with a history of previous oral carcinomas, chemotherapy, or radiation therapy in the head and neck region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-8nsbprb	Effects of Physical Training associated with Transcranial Direct Current Stimulation on the physical performance of individuals with Chronic Obstructive Pulmonary Disease - COPD	Not yet recruiting	Intervention	2024-05-29	<NULL>	<NULL>	7037	Effects of in-person and remote Physical Training and Transcranial Direct Current Stimulation on the functional, neuromuscular and mechanical performance of individuals with COPD: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Instituto de Educação Superior da Paraíba - IESP	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-8nsbprb	<NULL>	Subjects diagnosed with mild or moderate Chronic Obstructive Pulmonary Disease - COPD according to the Global Initiative for Chronic Obstructive Lung Disease criteria (GOLD 1: Forced expiratory volume in the first second (FEV1) mild ≥ 80% of predicted, GOLD 2: 50% moderate ≤ FEV1 &lt;80% of predicted); of both sexes; aged between 45 and 75 years; and classified as sedentary or insufficiently active (International Physical Activity Questionnaire - IPAQ, reduced version)	Individuals with acute exacerbation of Chronic Obstructive Pulmonary Disease - COPD, with unstable hemodynamic parameters (blood pressure &lt;100mmHg systolic and &lt;60mmHg for diastolic and Mean Arterial Pressure (MAP) &lt;80mmHg), who have undergone surgery in the last 6 months; with a recent history of chest wall trauma or abdominal trauma; and/or substantial chest wall deformity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-5s234bn	Immediate and adaptive effect of interventions with and without physical exercise on the quality of walking in people with Parkinson&apos;s disease	Not yet recruiting	Intervention	2024-05-28	<NULL>	<NULL>	7032	Acute and chronic effect of motor and non-motor intervention on gait asymmetry in patients with Parkinson&apos;s disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-5s234bn	<NULL>	For participants of the Parkinson group: have a minimum age of 50 and a maximum of 80 years; both genders; having a diagnosis by a private neurologist that indicates the presence of Idiopathic Parkinson Disease; have independent locomotion without the aid of auxiliary devices (cane, for example); being under drug treatment with stable levodopa for at least 3 weeks; not having undergone brain surgery or deep brain stimulation for Parkinson Disease treatment; no history of orthopedic and vision problems that make it impossible to comply with the experimental protocol (corrected vision with glasses is allowed); not having uncontrolled cardiovascular, metabolic or inflammatory problems; not showing advanced cognitive decline; present a medical certificate authorizing the performance of physical exercise. For control group participants: have a minimum age of 50 and a maximum of 80 years; both genders; independent locomotion without aid of auxiliary devices; not having history of orthopedic and vision problems that make it impossible to comply with the experimental protocol (corrected vision with glasses is allowed); not having uncontrolled cardiovascular, metabolic or inflammatory problems; not showing advanced cognitive decline	Do not present proof of Parkinson&apos;s disease, only for participants in the Parkinson&apos;s group in interventions 1 and 3; those with other neurological disorders; heart problems (i.e., arrhythmias, indication of myocardial ischemia); musculoskeletal disorders; cognitive deficits; brain surgery or Deep Brain Stimulation for the treatment of Parkinson disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-5kxg43n	To facilitate the postpartum breastfeeding process through the use of social media	Recruitment completed	Intervention	2024-05-28	<NULL>	<NULL>	7033	Social media as a tool for support and encouragement of postpartum breastfeeding: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Empresa Brasileira de Serviços Hospitalares - EBSERH	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-5kxg43n	<NULL>	Puerperal women  over the age of 18; who can read and write; have access to the WhatsApp platform; have been discharged from the hospital with their child	Puerperal women who were separated from their children for any reason during the study; who had illnesses contraindicating breastfeeding – HIV positive and Chagas disease ; who had premature conceptions or congenital problems such as cerebral palsy, microcephaly, or malformation of the digestive, cardiovascular, and oral cavity systems (factors that hinder the breastfeeding process)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-10w3kwxt	Effectiveness of Cognitive-Behavioral Therapy for adults with anxiety symptoms	Recruitment completed	Intervention	2024-05-28	<NULL>	<NULL>	7034	Online intervention in cognitive-behavioral therapy in adults with anxiety symptoms: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-10w3kwxt	<NULL>	Participants aged between 18 and 60 years old; who present symptoms of anxiety; have internet access; and agree to participate in the research by signing the Informed Consent Form; without restrictions regarding race, gender and sexual orientation	Participants not meeting the inclusion criteria; with a history of severe mental disorders (schizophrenia, bipolar disorder); currently undergoing psychotherapeutic treatment at the time of study inclusion; illiterate individuals; experiencing communication difficulties that compromise the understanding of the proposed interventions; engaging in abusive use of psychoactive substances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-27tzbmm	Effects of Slow Breathing on cardiovascular and hormonal changes during stress	Recruiting	Intervention	2024-05-28	<NULL>	<NULL>	7035	Effects of Slow Breathing on perception and cardiovascular and endocrine reactivity to stress	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-15	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-27tzbmm	<NULL>	Young adults (18 to 40 years old); of both sexes; eupneic (respiratory rate &gt; 10 breaths/minute); without diagnosis of mental disorders, cardiorespiratory and metabolic diseases, or cognitive deficit	Raynaud&apos;s syndrome or hypersensitivity to cold; using drugs that may influence the cardiovascular response; who regularly perform breathing or meditative practices; athletes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-65qchvs	Evaluation alveolar ridge values	Recruitment completed	Intervention	2024-05-28	<NULL>	<NULL>	7036	Efficacy evaluation of using Autologous tooth-derived Graft material in post-extraction dental socket preservation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-05	Universidade Tishreen	Universidade Tishreen	https://ensaiosclinicos.gov.br/rg/RBR-65qchvs	<NULL>	Patients of both genders; Individuals aged 18 to 64 years; non smokers; non-alcoholics; medically fit patients (no previous medical conditions such as heart, diabetes, hypertension, etc.); with indication of extraction of symmetrical teeth; integrity of dental sockets after extraction; patients who signed Informed Consent and attended follow-up sessions	Smokers; alcoholic; patients with infections in the gums or alveoli	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-5x936hn	Efficacy of a new intervention in the control of non-allergic Rhinitis: a randomized controlled trial	Not yet recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7026	Efficacy of cold bath as an intervention in the control of non-allergic Rhinitis: a randomized and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-06-03	M A Fornazieri Servicos Medicos (nome fantasia Clínica Olfact)	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-5x936hn	<NULL>	Participant aged between 18 and 55; have negative specific IgE (data from medical records) or negative Prick test (allergic skin test carried out at the Olfact Clinic); being diagnosed with non-allergic rhinitis	Have a history of allergy or hypersensitivity to budesonide; participant with a history of traumatic brain injury, due to the risk of neurological damage in association with hyposmia/anosmia; participants with acute or chronic rhinosinusitis; participant with a history of post-infectious olfactory loss; participants with neurodegenerative diseases, due to the high association with hyposmia/anosmia; participants with heart disease; participants with uncontrolled hypertension, asthma or chronic bronchitis; participants who are unable or unwilling to sign an Informed Consent Form or comply with the study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-10v25rm5	Importance of practicing physical activity during work hours	Recruitment completed	Intervention	2024-05-27	<NULL>	<NULL>	7027	Assessment of health parameters and quality of life of workers who perform workplace gymnastics	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-01-26	Universidade Federal de Jataí	Universidade Federal de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-10v25rm5	<NULL>	Workers who participate in Labor Gymnastics activities; do not have physical limitations that prevent them from carrying out the tests	Participants under 18 years of age; who are pregnant; those who did not carry out all the collection stages	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-39szpm6	Effect of several pre-exercise interventions on physical performance	Data analysis completed	Intervention	2024-05-27	<NULL>	<NULL>	7028	Different pre-exercise strategies on physical performance	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-03	Instituto de Ciências Biológicas da Universidade Federal de Juiz de Fora	Instituto de Ciências Biológicas da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-39szpm6	<NULL>	Healthy subjects; Age between 18 and 40 years old; male; experience with resistance exercise of at least one year	Smoking history; presence of any metabolic or cardiovascular disease; arterial hypertension (≥140/90 mmHg or use of antihypertensive medications); use of anabolic steroids, drugs or medications with potential impact on physical performance; recent musculoskeletal injury; previous experience with pneumatic occlusion intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-48gcrk8	Effects of Brain Stimulation on Anxiety, Inhibition Control and Risk taking behavior in young university students	Not yet recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7029	Effects of Transcranial Direct Current Stimulation on Anxiety, Inhibition Control and Risk taking behavior in young university students	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Universidade Federal do Delta do Parnaíba	Universidade Federal do Delta do Parnaíba	https://ensaiosclinicos.gov.br/rg/RBR-48gcrk8	<NULL>	University students; aged between 18 and 30 years old; from public and private institutions in the city of Parnaíba-PI; of both genders; who are currently attending university; scoring ≥ 15 points on the Hamilton Anxiety Rating Scale (HAM A); answering negatively to all questions on the non-invasive techniques screening instrument	Having a history of seizures, epilepsy, traumatic brain injury, or unexplained loss of consciousness; having a diagnosis of any neurological and/or cognitive conditions; currently being prescribed antipsychotic, hypnotic, or sedative medications; abusing/being dependent on substances, excluding tobacco and/or caffeine; having metallic implants in the body, such as pacemakers; presenting with skin diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-3sp77cq	Treatment study of Breast Cancer related Lymphedema	Not yet recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7030	Efficacy of Compressive Therapy with an Internal Foam Layer in reducing the volume of Breast Cancer related Lymphedema: randomized clinical trial	<NULL>	3, randomized-controlled, n/a	3	<NULL>	<NULL>	<NULL>	2024-08-01	Hospital do Câncer III	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-3sp77cq	<NULL>	Women aged 18 years and older; diagnosed with upper limb lymphedema after 6 months of surgical treatment for breast cancer; in the volume reduction phase, with 10 to 20% excess volume; classified as stage II according to the International Society of Lymphology classification, in which there is the presence of interstitial fibrosis; with or without a lock sign and with mild to moderate volume changes	Women undergoing bilateral lymphadenectomy or with bilateral lymphedema; lymphedema since the preoperative period; presence of phlogistic signs in the edematous limb; with lesions with loss of continuity in the skin of the limb with lymphedema; previous history of allergic reaction to the material used for compression therapy; active locoregional or distant disease; undergoing chemotherapy or radiotherapy; those with functional changes in the upper limbs prior to the diagnosis of breast cancer; those with heart disease and decompensated systemic arterial hypertension; psychiatric, mental, neurological disorders or cognitive deficits that make it impossible for them to answer the questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-5wq4msw	Effect of Reiki and Sweet Orange smell on the mental health of women after menopause	Recruiting	Intervention	2024-05-27	<NULL>	<NULL>	7031	Effect of Reiki Therapy and Inhalation of Citrus sinensis Essential Oil evaluation on Post Menopause women mental health	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-02	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-5wq4msw	<NULL>	Being post menopausal. Have a maximum post-menopause time of 10 years. Not taking hormonal treatment for menopause. Have a score greater than or equal to 10 points on the Beck Anxiety Inventory and or have a score greater than or equal to 11 points on the Beck Depression Inventory	Diagnosed with diabetes and or neoplasms for at least 5 years and severe cardiovascular diseases; those who are allergic to C. sinensis essential oil; take the following medications: metformin, enalapril, levothyroxine T4, puran T4, levothyroxine, insulin, inhaled fenoterol B2, amitriptyline, alprazolam (or frontal), losartan, hydrochlorothiazide (or chloran), relaxing herbal medicine, sertraline, captopril, vasopril, pondera, buspirone, amlodipine, fluoxetine, salbutamol, valsartan, domperidone, promethazine, citalopram, chlorthalidone, atenolol, ablok plus, aradois, rosuvastatin, zolpidem, copressotec, desvenlafaxine, clonazepam, diovan, minipres, euthyrox, venlafaxine, paroxetine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-4ttb63q	Clinical study of nuclear alterations in patients undergoing in-office tooth whitening	Data analysis completed	Intervention	2024-05-24	<NULL>	<NULL>	7022	Evaluation of the genotoxic potential of dental whitening in patients with different age groups: clinical study	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade de Odontologia - Universidade Federal do Amazonas	Faculdade de Odontologia - Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4ttb63q	<NULL>	Both sexes; age between 14 and 18 years old and 31 and 50 years old; no systemic diseases (metabolic, immunological and heart diseases); with oral condition free from carious lesions or periodontal diseases; central incisor or canine color A2 or darker; six upper anterior teeth free of restorations on the buccal surface; healthy enamel; dissatisfaction with the color of your teeth; no pathological changes; physiological and medicinal	Dentin hypersensitivity; smoker; alcoholic; pregnant or breastfeeding; orthodontic appliance; severe crowding, presence of intrinsic spots and ages between 19 and 30 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-3njdgg4	Effects of Auriculotherapy on Stress in healthcare workers	Not yet recruiting	Intervention	2024-05-24	<NULL>	<NULL>	7023	Effects of Auriculotherapy on subjective and objective Stress in healthcare workers: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Universidade do Estado da Bahia - Departamento Ciências da Vida	Universidade do Estado da Bahia - Departamento Ciências da Vida	https://ensaiosclinicos.gov.br/rg/RBR-3njdgg4	<NULL>	Volunteers with salivary cortisol and perceived stress levels above the general average; workers from Family Health Units; both genders; age between 18 and 70 years	Pregnant women; workers using antidepressants; bleeding oral lesions; treatment with auriculotherapy by other means	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-4bttxys	Evaluation of restorative treatments of posterior teeth severely affected by Molar incisor hypomineralization	Recruiting	Intervention	2024-05-24	<NULL>	<NULL>	7024	Evaluation of the use of Steel Crown, Band, and Rina Technique for the treatment of molars severely affected by Molar incisor hypomineralization: a randomized clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-28	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-4bttxys	<NULL>	Patients both genders; aged between six and twelve years; who have at least one fully erupted first permanent molar with incisor molar hypomineralization and loss of structure on at least three surfaces will be included (including those who have dentin sensitivity and associated carious lesions)	Teeth that have bands for orthodontic treatments; patients whose parents do not allow participation and who are not in good gingival health will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-2fr644j	Low-cost 3D-printed device for the Assessment and Training of Respiratory Muscles in the elderly	Not yet recruiting	Intervention	2024-05-24	<NULL>	<NULL>	7025	Use of a low-cost 3d printed Prototype in the Assessment and Training of the Respiratory muscles of elderly people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-04	Instituto de Ciências da Saúde - Universidade Federal da Bahia	Instituto de Ciências da Saúde - Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-2fr644j	<NULL>	Be 60 years of age or older; score from 1 to 5 on the visual frailty scale; score at least 19 points in the Mini-Mental State Examination (MMSE), if you are not illiterate, 23 points if you have 1 to 3 years of schooling, 24 points for 4 to 7 years of schooling and for more than 7 years of schooling , 28 points.	Having decompensated musculoskeletal and neurodegenerative diseases, chronic diseases (hypertension, diabetes mellitus, chronic pain); unstable cardiovascular and pulmonary diseases (acute heart failure, recent myocardial infarction, unstable angina, uncontrolled arrhythmias, asthma, among others) that make it impossible to practice the training protocol; smokers/smokers; practice or have practiced a pulmonary rehabilitation program in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-2nt4byr	Effect of Neuromodulation and Virtual Game on Cardiac Variation in Women with Fibromyalgia – a clinical trial	Recruitment completed	Intervention	2024-05-23	<NULL>	<NULL>	7021	Effect of combined transcranial direct current stimulation therapy and virtual reality on cardiac autonomic modulation in women with fibromyalgia - a double blind randomized clinical trial with crossover	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-18	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-2nt4byr	<NULL>	As inclusion criteria, was considered: women diagnosed with FM, aged between 30 and 50 years, who did not use medications that could interfere with the variables studied, such as cardiac beta blockers, and who signed the free and informed consent form.	As exclusion criteria: non-understanding of the task, assessed through the participant&apos;s ability to perform the task correctly after performing three attempts with explanation and demonstration by the evaluator.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-4cmhfbj	Laser therapy in the management of Type 2 Diabetes Mellitus: a randomized health study	Recruitment completed	Intervention	2024-05-22	<NULL>	<NULL>	7015	Photobiomodulatory Therapy in the metabolic control of Type 2 Diabetes Mellitus: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-06	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-4cmhfbj	<NULL>	Be aged 18 or over; both genders; have a diagnosis of type 2 diabetes mellitus; be being monitored at the Basic Health Units that are part of the study; have preserved cognitive capacity, which will be assessed using the Mini Mental State Examination (MEEN)	"Uncontrolled diabetes, measured at the time of recruitment or via information obtained from the patient; 
smoker; alcoholic; insulin therapy; people with neuromuscular or musculoskeletal diseases or conditions that contraindicate photobiomodulation"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-22gbgj8	Quality of recovery of patients who have their gallbladder removed by video surgery after giving Dipyrone to reduce postoperative pain. Controlled, randomized and double-blind clinical trial	Recruiting	Intervention	2024-05-22	<NULL>	<NULL>	7016	Quality of recovery of patients undergoing Videolaparoscopic Cholecystectomy after administration of Dipyrone to control postoperative pain. Controlled, randomized, double-blind clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-08-24	Fundação São Paulo - Campus Sorocaba da Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	Fundação São Paulo - Campus Sorocaba da Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-22gbgj8	<NULL>	Age from 18 to 66 years; patients who will be operated by Laparoscopic Cholecystectomy; American Society of Anesthesiology (ASA) physical status I or II	Refusal to participate in the study; inability to communicate due to changes in the level of consciousness, neurological disease or psychiatric illness; contraindication to any of the medications used in the study in question; history of alcohol or drug abuse;body mass index (BMI) greater than or equal to 40Kg/m²	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-10zr5mjp	Health conditions of people living with the Human Immunodeficiency Virus	Recruiting	Observational	2024-05-22	<NULL>	<NULL>	7017	Evaluation of trace elements, immunobiochemical profile, body composition and physical capacity of people living with HIV	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-05	Universidade Federal de Jataí	Universidade Federal de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-10zr5mjp	<NULL>	People of both sexes; diagnosed with HIV; age equal to or greater than 18 years; and who have been treated at the Testing and Monitoring Center – and Specialized Assistance Service (CTA/SAE) in Jataí for at least six months	People under 18; who are in the gestational and/or lactating period; those who do not complete all the collection stages and or withdraw during the study; who are taking medicines to treat illnesses other than HIV	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-6rzh4h2	Effectiveness of Dry needling as a treatment for long lasting Tinnitus	Data analysis completed	Intervention	2024-05-22	<NULL>	<NULL>	7018	Effectiveness of Dry needling as a treatment for Chronic tinnitus	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Hospital Edmundo Vasconcelos / Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	Hospital Edmundo Vasconcelos / Fundação Instituto de Moléstias do Aparelho Digestivo e da Nutrição	https://ensaiosclinicos.gov.br/rg/RBR-6rzh4h2	<NULL>	Patients over 18 years old; tinnitus for at least 3 months; trigger points on physical examination	Pulsatile tinnitus; coagulopathy or anticoagulant use; dermatological lesion at the needling site; pregnancy; needle phobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-57m3wnw	Effectiveness of Buzzy® and Pikluc® in relieving pain associated with intramuscular injection in children	Recruiting	Intervention	2024-05-22	<NULL>	<NULL>	7019	Effectiveness of Buzzy® and Pikluc® in relieving pain associated with intramuscular injection in children: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Programa de Pós-Graduação em Enfermagem da Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão da Secretaria de Estado da Saúde de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-57m3wnw	<NULL>	To be in the age range of 1 to 11 years, 11 months, and 29 days old. Have a medical prescription for intramuscular injection	Child with Raynaud&apos;s disease or other vasospastic disorders. Hypersensitivity to cold. Cardiac disorders with impairment of local circulation. Rheumatoid disease. Hypertensive disease. Anesthetized skin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-4zg4nnz	Comparison between Passiflora incarnata Linnaeus and the mixture of Nitrous Oxide and Oxygen in children with anxiety in the dental environment	Recruitment completed	Intervention	2024-05-22	<NULL>	<NULL>	7020	Comparative study between Passiflora incarnata Linnaeus and the mixture of Nitrous Oxide with Oxygen in the control of anxiety in attendance pediatric dentist	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2023-03-15	Faculdade de Odontologia de Piracicaba - Unicamp	Faculdade de Odontologia de Piracicaba - Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-4zg4nnz	<NULL>	Children classified according to the American Society of Anesthesiologists (ASA) in ASA I – healthy patient; Both sexes; Child aged between five and twelve years; Accompanied by their parents/guardians, who presents bad behavior, fear and/or anxiety that are resistant to dental treatment, postponing the clinical procedure; Difficulty or behavioral management problems that provide a challenge to the dental surgeon in practice clinic; When basic techniques (voice control, speak-show-do, and protective stabilization) are not permitted or cannot be carried out effectively and safely, due to control of behavior is not enough; No communication difficulties; Children who need simple extraction of deciduous molars, which have at least 2/3 of the root; With periapical radiography of the tooth that will be extracted; Children who accept the mask and collaborate with the technique.	Pre-collaborative children; History of taking medication for pain or anxiety in the 15 days prior to the study; Allergy to drugs, substances or materials used in this experiment; Patients with respiratory tract infections such as the common cold, tonsillitis or nasal obstruction; Mouth breathers due to nasal adenoids; Patient with pneumothorax, cystic fibrosis, infection or recent middle ear surgery and bladder obstruction; Patients who do not accept the mask; Child with chronic obstructive pulmonary disease; Heart disease; Patients with sinusitis or surgeries otolaryngology in the last 14 days; Patients with a strong gag reflex; Patients with disorders muscle tone (cerebral palsy); Presence or suspicion of tumors; Children undergoing chemotherapy use bleomycin or have used it for less than 1 year; Radiotherapy; Osteomyelitis; Psychotic patients; Patients with porphyria; Children whose parents refuse to collaborate with research; Children who do not does not let you touch at all and/or does not sit in the chair; Children who do not accept to participate in the search.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-6g2vcnx	Evaluation of the effect of a neuromuscular blocker in patients undergoing gastric bypass surgery by videolaparoscopy	Recruitment completed	Intervention	2024-05-21	<NULL>	<NULL>	7014	Evaluation of the effect of moderate and profound neuromuscular blockers in patients undergoing laparoscopic roux-en-y gastric bypass	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-6g2vcnx	<NULL>	aged between 18 and 65 years, both sexes, with an ASA  score from 1 to 3, undergoing roux-en-y gastric bypass by robotic surgery will be included in the study.	Patients with cardiac arrhythmias, dilated cardiomyopathy, cardiac conduction disorder, electrolyte disturbance, acid base disturbance, known or suspected allergies to drugs used during anesthesia, family history of neuromuscular disease, family history of malignant hyperthermia, and renal failure, psychiatric, hepatic, respiratory or oncological diseases, who are receiving any type of analgesic in the week before surgery and those who receive blood products during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-106g42nw	The effect of Sparkling Water on patients with Difficulty Swallowing liquids	Suspended	Intervention	2024-05-20	<NULL>	<NULL>	7012	The effect of Carbonated Water on patients with liquid Dysphagia	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-04-19	Emille Dalbem Paim	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-106g42nw	<NULL>	Adults over 18 years of age of both genders; individuals who present penetration and/or laryngotracheal aspiration for liquids during the video swallow examination	Patients with contraindication for testing with liquids (those with evidence of massive aspiration of moderately thickened food where it is necessary to interrupt the test due to safety protocol, who have a previous tracheoesophageal fistula diagnosed or who do not present any swallowing response); individuals who present clinical instability and sensory oscillation that make it impossible to perform the exam; individuals who present postural changes that limit positioning for the exam; patients who are allergic to barium contrast	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-2bd7gnb	The long-term effects of Betaine supplementation on Cholesterol, Blood Sugar levels, Body Measurements, Cardiovas-cular Health, and Exercise Habits in adults who engage in Weightlifting	Not yet recruiting	Intervention	2024-05-16	<NULL>	<NULL>	7009	Chronic effects of Betaine supplementation on Lipid and Glycemic profile, Anthropometric and Cardiovascular parame-ters, and on Physical Exercise practice in adults engaged in Weightlifting: a randomized, double-blind, placebo-contro-lled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-10	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2bd7gnb	<NULL>	Male individuals; practicing physical activity; within the age range of 35 to 55 years; who have been engaged in weightlifting for a minimum of 6 months; exercising for at least 30 minutes, 3 times a week; willing to be evaluated by a nutritionist; agreeing to be supervised by a fitness professional who will determine and oversee their weightlifting training; and committing to at least 9 days of training during the study period under the supervision of the fitness professional	Smokers; individuals with any reported chronic diseases such as cardiovascular diseases, metabolic syndromes, pulmonary diseases, and renal diseases; individuals with orthopedic problems and/or muscular or orthopedic injuries; individuals using any type of steroids, supplements, or herbal remedies; individuals with needle phobias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-9jf5bmj	Effect of the Low Level Light Therapy on measurable variables of the autonomic nervous system in people with Cerebral Palsy	Recruiting	Intervention	2024-05-16	<NULL>	<NULL>	7010	Effect of the Photobiomodulation on measurable autonomic nervous system variables in people with Cerebral Palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-20	Centro de Estudos da Educação e Saúde - CER II - Universidade Estadual Paulista	Faculdade de Filosofia e Ciências da Universidade Estadual Paulista - Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-9jf5bmj	<NULL>	Age between 5 and 20 years; both genders; cerebral palsy diagnosys; at levels I to V of the Gross Motor Function Classification System (GMFCS)	Individuals with neoplastic areas; bleeding episode; thermal sensitivity disorders; use of photosensitive drugs; have more than two consecutive faults	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-10gm45rd	Assessment of skin irritability after using a medical device	Not yet recruiting	Intervention	2024-05-16	<NULL>	<NULL>	7011	ORC_95616_EN23-0748-01_Assessment of primary dermal irritability, cumulative dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-10	Medcin Instituto da Pele LTDA	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-10gm45rd	<NULL>	Participants of both sexes aged 18 to 70; phototype: I, II, III and IV; skin in the application region is complete; agreement to follow the trial procedures and attend the clinic on the specified days and times; understanding, consent and signature of the free and informed consent form	Pregnancy or risk of pregnancy and/or lactation; use of anti-inflammatory drugs 30 days and/or immunosuppressants for up to three months before selection; immunosuppression by drugs or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; expect intense exposure to sunlight or tanning sessions during the study period; provision for bathing in the sea, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks before selection; vaccination scheduled during the study period or up to 3 weeks before selection; history of sensitization, irritation or photosensitization to topical products; active skin pathologies that may interfere with the study results; skin reactivity; use of new medications/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient of the study product; history of lack of adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or an immediate family member of an employee involved in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-2zz8cg8	Shock waves in knee extension of individuals with Cerebral Palsy	Data analysis completed	Intervention	2024-05-15	<NULL>	<NULL>	7005	Effect of shock waves on knee range in individuals with Cerebral Palsy: case study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Centro de Estudos da Educação e Saúde - CER II - Universidade Estadual Paulista	Centro de Estudos da Educação e Saúde - CER II - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2zz8cg8	<NULL>	Ter idade entre 3 e 12 anos, com diagnostico de Paralisia Cerebral diparética espástica; não ter recebido tratamento prévio de toxina botulínica ou cirúrgico nos seis meses que antecederam a primeira coleta; apresentar grau três ou quatro de espasticidade classificada pela Escala Modificada de Ashworth; apresentar classificação II, III ou IV no Sistema de Classificação da Função Motora Grossa - GMFCS	Two absences during the protocol application period; presenting pain in the lower limbs that makes shock wave therapy unfeasible and assessment protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-10tkvrv6	Impacts of cough-assist machine on success rate of weaning of patients on prolonged mechanical ventilation	Recruitment completed	Intervention	2024-05-15	<NULL>	<NULL>	7006	Impacts of adding mechanical insufflation-exsufflation on success rate of weaning of patients on prolonged mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Hospital Universitário da Universidade Federal de Juiz de Fora	Hospital Universitário da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10tkvrv6	<NULL>	Pacientes aged more than 18 years; mechanical ventilation for more than 21 days; mechanical ventilation through tracheostomy; fulfill criteria for weaning; respiratory stability; hemodynamic stability; uncontrolled infection; no severe mebolic disturb	"Pneumothorax; subcutaneous emphysema; pneumomediastinum; thoracic trauma; 	haemoptysis; intracranial hypertension; readmission to ICU after discharge already tracheostomised; palliative care; refusal to sign the informed consent by the responsible family member"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-10cqv83n	Application of myofascial release aiming to prevent injuries in athletes	Not yet recruiting	Intervention	2024-05-15	<NULL>	<NULL>	7007	Myofascial release and injury prevention	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-10cqv83n	<NULL>	Participants must practice Taekwondo at least twice a week for two cycles; have at least 12 years old; both genders	To perform some preventive monitoring within the practice of the sport; already be injured at the beginning of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:05
RBR-3xsnft5	Comparison of healing and pain after surgery to remove a gingival graft from the palate protected by light-cured fluid composite resin and cyanoacrylate-based tissue adhesive	Not yet recruiting	Intervention	2024-05-14	<NULL>	<NULL>	7003	Comparative analysis of healing and posoperative pain in donor sites of free gingival graft protected with flowable resin composite and cyanoacrylate tissue adhesive	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-3xsnft5	<NULL>	To be 18 or over; do not report the presence of systemic diseases; present healthy periodontium and periodontal stability after conventional periodontal therapy; present a plaque and bleeding index on probing &lt; 10% of sites; needing periodontal plastic surgery using a deephelialized free gingival graft (EGL-d) to treat single and multiple gingival recessions (Class I and II of Cairo, 2011) in the mandible or anterior region of the maxilla (canine to canine); no previous history of palatal graft removal	Pregnancy; report use of medication that may have an adverse effect on periodontal tissues; inadequate endodontic treatment; tooth mobility at the surgery site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-8ngyxny	Metabolism of bioactive compouds from jaboticaba powder in adults	Recruitment completed	Intervention	2024-05-13	<NULL>	<NULL>	7001	Metabolism of ellagitannins from jaboticaba powder in adults	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-10	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8ngyxny	<NULL>	Men and women; body mass index between 18.5 kg/m2 and 40.0 kg/m2; age between 19 and 59 years old	Pregnant or lactating women; volunteers who have been on a weight loss diet in the last three months; volunteers who have difficulty taking capsules or tablets; volunteers who report food allergies; volunteers who report chronic diseases, especially liver diseases; consumers; alcoholics; routine use or in the last three months of medications, antibiotics, anti-inflammatories, antifungals, probiotics or nutritional supplements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-10v99xgj	Effects of Multicomponent Physical Exercise and Auriculotherapy in the elderly	Not yet recruiting	Intervention	2024-05-13	<NULL>	<NULL>	7002	Effects of a Physical Exercise protocol Multicomponent and Auriculotherapy in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-13	Universidade Comunitária da Região de Chapecó	Universidade Comunitária da Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-10v99xgj	<NULL>	Physiotherapeutic and/or medical diagnosis of chronic low back pain; (2) age group between 60 and 75 years old and of both sexes; preserved cognitive, assessed by the Mini-exam Mental State; chronic low back pain, defined as a complaint of pain in the lumbar region below the twelfth thoracic vertebra, with or without irradiation, lasting more than six months and with a moderate to intense degree of intensity, tested by the Visual Analogue Pain Scale	Missing two consecutive sessions of intervention or three interspersed; (2) carrying out acupuncture treatment in the last six months; undergoing physiotherapeutic treatment in the last three months; have neurological injuries or disorders that compromise walking and execution of exercises; have tumors or are undergoing cancer treatment; present bone or marrow infections and ankylosing spondylitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-9xhn6qn	Effect of physical exercise on functional capacity, muscle strength and quality of life in patients with liver cirrhosis	Not yet recruiting	Intervention	2024-05-10	<NULL>	<NULL>	6999	Effect of physical exercise program on functional capacity, peripheral muscle strength, respiratory muscle strength and quality of life in patients diagnosed with liver cirrhosis: randomized controlled experiment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-01	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-9xhn6qn	<NULL>	Patients diagnosed with liver cirrhosis with Child A classification; both sexes; minimum age of 18 years and undergoing clinical monitoring	volunteers with encephalopathy from grade 2 (through clinical diagnosis); who had esophageal varices in the last 6 months (through clinical diagnosis); volunteers who have respiratory pathologies and/or associated musculoskeletal pathologies (through medical diagnosis prior to the research); and exercisers for at least 3 months (self-report)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-6sz8zht	A clinical study to investigate the effects of oral immunonutrients during the perioperative period of patients with gastrointestinal cancer	Not yet recruiting	Intervention	2024-05-10	<NULL>	<NULL>	7000	Effects of enteral supplementation with immunonutrients in the perioperative course of patients with cancer of the gastrointestinal tract: A double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-6sz8zht	<NULL>	Patients aged over 18 years will be included; with anatomopathological examination that shows any histological type of cancer of the gastrointestinal tract; who will undergo any curative and elective surgical procedure	Pregnant women will be excluded; people submitted to the use of artificial nutrition in the 15 days prior to inclusion in the study; people allergic to any components of the diet; people with any gastrointestinal diseases prior to the malignancy; people with immunosuppression or using immunosuppressive therapies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-5jy7kzj	Use of music with the objective of reducing anxiety in patientes who will have coronary angioplasty	Not yet recruiting	Intervention	2024-05-09	<NULL>	<NULL>	6998	Music in anxiety and stress in patientes who will undergo transluminal coronary angioplasty: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Rodrigo Assis Neves Dantas	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-5jy7kzj	<NULL>	Patients aged 18 years or over; patients undergoing angioplasty for the first time; patients scheduled on an outpatient basis; absence of the use of sedatives or anxiolytics; possibility of assessment with anxiety and stress scales	Patients with neurological problems; patient with hearing impairment; using anxiolytic medication or antidepressant drug; don&apos;t like music	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-2skzz8s	Parenting for mothers of premature infants	Recruiting	Intervention	2024-05-08	<NULL>	<NULL>	6991	Parenting-promoting intervention for mothers of preterm infants: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal do Ceará	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-2skzz8s	<NULL>	Inclusion criteria for mother and baby; Mother with at least one child admitted to UCINCa; Preterm baby with corrected Capurro gestational age (IgCC) at birth between 28 weeks and 36 weeks and 6 days, both genders; Baby who at the time of the intervention has between 36 weeks and 3 months of IgCC; Clinically hemodynamically stable baby	Mother and baby exclusion criteria; Mother with cognitive limitation or psychiatric disorder that prevents her from participating in the intervention; Baby who is the twin of a study participant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-6npgqzw	Muscle effects of Neuromuscular Electrostimulation in mechanicallu ventilated patients in an Intensive Care Unit	Recruiting	Intervention	2024-05-08	<NULL>	<NULL>	6992	Electrostimulation in mechanically ventilated patients in an ICU	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-08	Hospital Universitário Pedro Ernesto	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6npgqzw	<NULL>	Patients from the General Intensive Care Center sector – General ICC; aged 18 or over; of both sexes; who are on mechanical ventilation in the first 24 hours	Trauma to the lower limb; history of neurological, neuromuscular or debilitating diseases; spinal cord injury; rhabdomyolysis; vascular insufficiency or amputation of the lower limb; previous immobility; epilepsy and musculoskeletal and skin conditions; or situations that may interfere with the conduct	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-55bxn5w	Application of Lactobacillus reuteri as a contributor to Dental scaling Sreatment	Recruiting	Intervention	2024-05-08	<NULL>	<NULL>	6993	Application of Lactobacillus reuteri as an adjuvant in therapy non-surgical periodontal	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-05	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-55bxn5w	<NULL>	Patients over the age of 18;Insertion Loss of 5 mm or more (Stage III of the New Classification of Periodontal Diseases) - non-adjacent interproximal teeth of hemi-arches lower anteriors; Non-smokers; Non-pregnant women; Non-lactating; Patients who agreed to take part in the research by signing the Term Free and Informed consent	Patients under 18 years of age; That does not present a loss of Insertion of 5 mm or more (Stage III of the New Classification of Periodontal Diseases) - non-adjacent interproximal teeth of lower anterior hemi arches; Smokers; Pregnant women;Nursing mothers; Patients who did not agree to sign the Free and Consent Form Enlightened	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-4nkyrct	Impact of not removing bubbles generated during in-office bleaching in adult patients: Single-blind, split-mouth, randomized clinical trial	Data analysis completed	Intervention	2024-05-08	<NULL>	<NULL>	6995	Impact of not removing bubbles generated during in-office bleaching in adult patients: Single-blind, split-mouth, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Elder Jossué Romero López	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4nkyrct	<NULL>	Age from 18 years old; regardless of sex; have good general and dental health conditions; upper teeth free of cavities and upper front teeth free of restorations on the buccal surface; in addition to central incisors showing C2 or darker color; evaluated in comparison with a visual color scale guided by the value of the teeth	Pregnant or breastfeeding women; users of fixed orthodontic appliances; with pre-existing previous restorations; presence of severe intrinsic stains on the teeth; participants with a previous history of tooth sensitivity or any associated pathology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-9vcph8x	Application of Whole Body Red Light in patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2024-05-08	<NULL>	<NULL>	6996	Whole-body photobiomodulation of patients with Chronic Obstructive Pulmonary Disease, randomized crossover, single-blind, sham-controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-23	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9vcph8x	<NULL>	Patients of both sexes; over forty years of age  forty years or older; with a clinical diagnosis of Chronic Obstructive Pulmonary Disease - COPD; classified by Chronic Obstructive Lung Disease GOLD as moderate and severe; clinically stable; non-smokers and former smokers; without exacerbations in the last four weeks; and who have not participated in any application of whole-body light	Patients who present exacerbation of symptoms in the four weeks prior to the collections; those with spinal cord trauma that prevents the tests from being performed; chronic neurological disorder; progressive neuromuscular disease; recent cancer treatment; symptoms of exertion intolerance at baseline such as: respiratory rate greater than 35 breaths per minute, signs of respiratory distress, use of accessory muscles, paradoxical breathing, saturation less than 85 and heart rate greater than 120 beats per minute at rest and breathing in room air	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-2k228rg	Healing action of green propolis in increasing the number of cells and their migration and evaluation of healing activity in patients with wounds on the lower limbs caused by Leprosy	Recruitment completed	Intervention	2024-05-08	<NULL>	<NULL>	6997	In vitro effect of green propolis on cell proliferation and migration and clinical evaluation of its healing activity in patients with ulcers in the lower limbs resulting from Leprosy	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-07-16	Universidade São Francisco	Associação Filantrópica Humanitas	https://ensaiosclinicos.gov.br/rg/RBR-2k228rg	<NULL>	Patients of both sexes; age over 18; already treated and cured of leprosy; who had lower limb wounds with an area between 3 and 75 square centimeters	People allergic to propolis; patients diagnosed with critical ischemia or who have had a serious uncontrolled infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-7cf5tmv	Laser effects in women with vocal disorders	Data analysis completed	Intervention	2024-05-07	<NULL>	<NULL>	6988	Immediate effects of low-intensity Laser Photobiomodulation in women without vocal complaints and in dysphonic women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-24	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7cf5tmv	<NULL>	Vocally healthy participants - women aged 18 to 45; no vocal complaints or laryngeal injuries; neutral vocal quality. Dysphonic participants - women aged 18 to 45; with complaints or altered vocal quality or diagnosis of benign lesions of the larynx	Pregnant women; women in the premenstrual period; with an allergic reaction, and/or respiratory condition on the day of the assessment; with a systemic, neurological, and/or neoplastic disease; smokers; women who had been previously submitted to speech-language-hearing and/or surgical treatment due to voice changes; who were photosensitive or had a skin disease/lesion; who had a tattoo in the region where light would be applied; and those who reported taking skin treatment medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-77nkbgc	The immediate effect of Intermittent Hypoxia on Parkinson&apos;s Disease and its effects on gait, sleep quality, and blood biomarkers	Recruitment completed	Intervention	2024-05-07	<NULL>	<NULL>	6989	Intermittent hypoxia in Parkinson&apos;s disease: acute effect on locomotion, sleep quality and biomarkers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-06	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-77nkbgc	<NULL>	Age equal to or over 50 years old. Both genders. Have independent mobility without the aid of auxiliary devices (e.g., cane). No history of orthopedic or vision problems that would make it impossible to comply with the experimental protocol. No uncontrolled cardiovascular, metabolic or inflammatory problems. Especially for people with Parkinson&apos;s Disease, inaddition: have a diagnosis from a private neurologist that indicates the presence of idiopathic Parkinson&apos;s Disease determined by the London Brain Bank; be under stable drug treatment with Levodopa for at least 3 weeks and have not undergone brain surgery or deep brain stimulation to treat Parkinson&apos;s Disease	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-104gykws	Reduction in sedentary lifestyle after stroke	Data analysis completed	Intervention	2024-05-07	<NULL>	<NULL>	6990	Reducing sedentary behavior after stroke	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Hospital Municipal São José	Hospital Municipal São José	https://ensaiosclinicos.gov.br/rg/RBR-104gykws	<NULL>	Individuals aged 18 years or over; of both sexes; capable of walking independently or with supervision able to use an assistive device; diagnosed with a stroke; clinically stable and accepting to participate in the research by signing the Free Consent Form and Clarified TCLE	Individuals with severe cognitive impairment; severe aphasia; walking dependent on assistance from another person or unable to walk; severe heart disease; and impossibility of telephone contact after hospital discharge	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-9252kwm	Effects of Spinal Cord Electrostimulation on Chronic Pain	Recruiting	Intervention	2024-05-06	<NULL>	<NULL>	6987	Effects of Transcutaneous Medullary Direct Current Stimulation on Chronic Pain: randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-9252kwm	<NULL>	Adults between 18 and 80 years old; with hearing acuity; no history of neuropsychiatric disorders or self-reported use of psychoactive substances; that are sufferers of chronic pain (for more than 3 months)	Individuals with epilepsy, taking anticonvulsant medication, and/or experiencing sleep deprivation; participants with metallic materials implanted in or near the head (e.g., cochlear implant, implanted electrodes/stimulators, aneurysm clips or coils, firearm projectile fragments, jewelry, and hair clips); participants with pacemakers or cardiac wires (Stents), or any other active device where interaction with an electric field may interfere with its functioning; participants with eczema on the head or trunk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-8xkp7wr	Use of lasers for the treatment of hypersensitivity in children with Molar Incisor Hypomineralization (MIH) and the impact on quality of life in relation to oral health	Recruiting	Intervention	2024-05-03	<NULL>	<NULL>	7869	Use of high and low power lasers for the treatment of dentin hypersensitivity in children with Molar Incisor Hypomineralization (MIH) and the impact on quality of life in relation to oral health	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8xkp7wr	<NULL>	Minimum age of 7 years and maximum age of 17 years; presence of molar-Incisor hypomineralization and mild, moderate or severe dentin hypersensitivity in at least 1 tooth with hypomineralization; the guardian must sign the informed consent form (TCLE) and the child, the informed consent form (TALE)	Presence of any type of systemic pathology; presence of pre-malignant lesion; children who do not allow the procedure; partially erupted hypomineralized teeth; hypomineralized teeth with lesions with pulp involvement; hypomineralized teeth with restorations or carious lesions; hypomineralized teeth with orthodontic bands; patients who used desensitizers in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-109h3wcv	Influence of different products on the effectiveness and duration of treatment of sensitive teeth and patients&apos; well-being	Recruiting	Intervention	2024-05-02	<NULL>	<NULL>	6982	Influence of different topical desensitizing medications on the effectiveness and durability of treatment of dentin hypersensitivity and quality of life of patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-15	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-109h3wcv	<NULL>	Patients with dentin hypersensitivity in at least 3 teeth with loss of tooth structure of less than 1mm; moderate to severe dentin hypersensitivity (pain greater than 3); Individuals who are interested in the treatment of dentin hypersensitivity; agree to participate and sign the free and informed consent form; participants aged between 18 and 60	Presence of dentin sensitivity caused by the presence of caries or unsatisfactory restorations; patient undergoing orthodontic or periodontal treatment; patients undergoing teeth whitening; presence of spontaneous pain in the tooth with dentin hypersensitivity, characterizing pulpitis; presence of periodontal disease; poor and unsatisfactory oral hygiene; use of extensive prostheses; patients with severe bruxism and changes in vertical dimension; patients with uncontrolled gastroesophageal reflux disease; patients with uncontrolled systemic or psychological illnesses; patients who use controlled medications that interfere with salivary flow; pregnant and lactating women; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-6v7m9zk	Influence of ozone on color change and pain during at-home dental bleaching: a clinical trial	Recruiting	Intervention	2024-05-02	<NULL>	<NULL>	6983	Influence of ozone oil on color change and reduction of dentin sensitivity during at-home dental bleaching: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-6v7m9zk	<NULL>	Patients aged 18 to 40 years; good oral and general health; anterior-upper teeth free of restorations and carious lesions; canine color 2.5M2 or darker according to the Vita Bleached 3D Master color scale (Vita Zahnfabrik, Bad Säckingen, Germany); agreement with the informed consent form (ICF)	Patients with severe discoloration; enamel hypoplasia; gingival recession; dentin exposure; visible enamel cracks; pulpitis or endodontic treatment on any of the six upper anterior teeth; participants who have undergone previous whitening procedures; have prior dental sensitivity; continuously use anti-inflammatory or analgesic drugs; smoke; exhibit parafunctional habits; are using fixed or removable orthodontic appliances; pregnant or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-25kmmdk	Benefits of Gestational Diabetes Education for Pregnant Women	Recruiting	Observational	2024-05-02	<NULL>	<NULL>	6984	Effectiveness of using a digital booklet for health education about gestational diabetes	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Católica de Santos	Universidade Católica de Santos	https://ensaiosclinicos.gov.br/rg/RBR-25kmmdk	<NULL>	Being female; be 18 years of age or older; reside in Brazilian territory; be pregnant; declare to know how to read and type; agree to the Free and Informed Consent Form	Being male; be a minor; do not reside in Brazilian territory; not being pregnant; not have literacy; not agreeing to the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-8v96qwb	Effect of Floral Therapy on Anxiety in caregivers of elderly individuals at home	Recruiting	Intervention	2024-05-02	<NULL>	<NULL>	6985	Effectiveness of Floral Therapy in the Anxiety of informal caregivers of dependent elderly individuals at home: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Enfermagem da Universidade Estadual de Campinas - UNICAMP	Faculdade de Enfermagem da Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-8v96qwb	<NULL>	Informal caregivers (who do not receive remuneration for performing this role); of both sexes; aged 18 or older; responsible for the care of elderly individuals (aged 60 or older) participating in the &quot;Better at Home Program&quot; within the Home Care Service of Piracicaba/SP - Brazil; who exhibited moderate or high anxiety according to the State-Trait Anxiety Inventory criteria (score greater than 34)	Female volunteers with suspected pregnancy or already pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-62v9htw	Clinical study of children health	Recruiting	Intervention	2024-05-02	<NULL>	<NULL>	6986	Impact of the Herbst appliance in the management of Obstructive Sleep Apnea in patients with class II, division 1 malocclusion: randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo (FOB-USP)	Faculdade de Odontologia de Bauru - Universidade de São Paulo (FOB-USP)	https://ensaiosclinicos.gov.br/rg/RBR-62v9htw	<NULL>	Individuals aged between 9 and 14 years; both genders; in stages of cervical maturation Cervical Stage 2 or 3 according to the Cervical Vertebrae Maturation method, carriers of Class II division 1 malocclusion (skeletal parameter: ANB &gt; 4); dental parameter: minimum severity of ½ Angle Class II) and diagnosed with Obstructive Sleep Apnea (OSA), screened by the validated Brazilian version of the Pediatric Sleep Questionnaire and confirmed by polysomnography (PSG)	Hyperdivergent individuals; those with craniofacial syndromes and anomalies; individuals who have undergone previous orthodontic treatments with headgear, jaw breakers, any type of functional orthopedic appliance and fixed appliances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-10htn4xy	Effect of Dry Needling on the psychoacoustic characteristics of Somatosensory Tinnitus	Not yet recruiting	Intervention	2024-04-30	<NULL>	<NULL>	6979	Somatic Tinnitus and Trigger Points	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10htn4xy	<NULL>	Over 18 years old; both sexes; constant or intermittent tinnitus, uni or bilateral and chronic; tinnitus must be perceptible at the time of the evaluation, in the in case it&apos;s intermittent; modulation of tinnitus during muscle palpation, at least in one trigger point	Patients with alterations and/or systemic diseases not controlled; patients with diseases of the central nervous system; Patients undergoing treatment using ototoxic medications; Patients with a history of alcohol and/or drug abuse; Patients afraid of needles; patients receiving dry needling treatment previously; patients with impaired language or cognition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-3jsvtbr	Effects of Cannabis Oil on respiratory and cardiovascular function in healthy individuals: a randomized clinical trial study	Recruiting	Intervention	2024-04-30	<NULL>	<NULL>	6980	Acute effects of the action of Cannabis Oil in Full Spectrum protection and THC isolate on respiratory mechanics, peripheral cardiovascular hemodynamics and muscular electrical activity in healthy individuals	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-3jsvtbr	<NULL>	Both sexes; young people; between 18 and 50 years old; who declare themselves healthy; with body mass index (BMI) within normal limits; that do not present changes in respiratory function; do not present uncontrolled/treated psychological disorders; do not use regular medications; have not had exposure to Cannabis in the last 6 months	Dropouts; are unable to understand or carry out any of the study steps; present some clinical instability during the procedures (HR greater than 85% of their maximum HR; present before or during the assessment hypertensive peak with SBP&gt; 180 and/or DBP&gt;110 and/or hypertensive crisis with BP&gt;190/90 mmHg or 175/115 mmHg); women who are pregnant at the time of collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-3jfptf2	The effect of Manual Treatment in patients with type 2 Diabetes	Recruiting	Intervention	2024-04-30	<NULL>	<NULL>	6981	Efficacy of the Osteopathic Manipulative Treatment in patients with type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-02	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-3jfptf2	<NULL>	Age between 40 and 80 years; Diagnosis of Type 2 Diabetes Mellitus, that is, fasting blood glucose equal to or above 126 mg/dl; Present stability in drug treatment, if they use it; Patients with or without diabetic neuropathy; Agree to the free and informed consent form	"Continuous use or chronic use of medications that may interfere with the study, such as
immunosuppressants, chemotherapeutics; pregnant women; Patients with a history of type 2 Diabetes Mellitus complication; Have undergone osteopathic treatment in the last 3 months; Present diseases that may interfere with the study, such as infections, tumors and SAH; Abdominal surgeries, syndromes, phobias and mental disorders; Age below 40 and above 80 years"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-83cj4wn	Treatment of ligneous conjunctivitis with platelet-rich plasma	Recruiting	Intervention	2024-04-29	<NULL>	<NULL>	6975	Use of Platelet-enriched allogeneic serum eye drops as an adjuvant for the treatment of recurrent Ligneous conjunctivitis	<NULL>	1, n/a, n/a	1	<NULL>	<NULL>	<NULL>	2024-04-03	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-83cj4wn	<NULL>	Patients diagnosed with ligneous conjunctivitis with chronic ocular involvement (more than 1 year of disease) who do not respond to clinical treatment and present recurrence of pseudomembranes after simple resection or after attempted clinical treatment. Age from 2 years. Availability to attend all study visits and adequately follow all post-operative guidelines and care. Understanding of the study, stages and follow-up, and agreement expressed by signing the consent form (by the patient or guardian) and assent form (when applicable). Stable clinical condition and no change in topical medications or systemic anti-inflammatory drugs in the 60 days prior to and during the study. Carry out a complete pre-operative assessment, including general and specific complementary exams as clinically indicated and pre-anesthetic assessment	Eye surgery in the last 6 months. Patients with a previous history of hypersensitivity to any of the products used to treat ligneous conjunctivitis included in this protocol. Pregnant or breastfeeding women. Active eye infection. History of herpetic keratitis. Use of contact lenses within 48 hours of the start of the study, or during the study. Glaucoma. Presence of any other serious ocular change that indicates the need to perform another ophthalmological procedure more urgently, such as retinal detachment or ocular perforation. Contraindication to carrying out the procedure by the anesthesiology team	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-5zr9qss	Long-term evaluation of teeth supporting a removable partial denture - influence of plaque disclosing agent on dental cleaning	Recruiting	Intervention	2024-04-29	<NULL>	<NULL>	6976	Longitudinal evaluation of remaining teeth of removable partial denture wearers - influence of plaque disclosing agent on biofilm control	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-28	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5zr9qss	<NULL>	Volunteers 20 years old or more; partially edentulous in one or both jaws who received a removable partial denture at the Federal University of Santa Catarina	Individuals with natural dentition without the need for removable partial dentures; those who have not adapted to new prostheses; individuals with a history of painful temporomandibular disorder symptoms; the presence of uncontrolled systemic disease; patients with mental disorders; cognitive impairment; previous periodontal disease with residual dental mobility; smokers and/or alcoholics patients; pregnant or lactating individuals will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-32c43kw	Impact of abreviation of preoperative fasting on cost-effectiveness in surgical patients	Data analysis completed	Observational	2024-04-29	<NULL>	<NULL>	6977	Impact of ACERTO Protocol in cost-effetiveness in surgical patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-32c43kw	<NULL>	This is a retrospective study; collecting data from patients admitted to the surgical clinic ward at the Julio Muller University Hospital (HUJM) in the city of Cuiabá – MT; of both sexes; during the period from January 2019 to December 2019	Pregnant women; and children under 18 years of age; and those whose medical records did not have sufficient information	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-5g4p9q8	Assessment of a cryotherapy crpotocol on the occurrence of postoperative endodontic pain in molars with irreversible pulpitis: a randomized clinical trial	Recruiting	Intervention	2024-04-29	<NULL>	<NULL>	6978	Assessment of a cryotherapy protocol on the occurrence of postoperative endodontic pain in molars with irreversible pulpitis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-04	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-5g4p9q8	<NULL>	The inclusion criteria will involve recruiting capable adult patients (18 to 65 years old) who already have an indication for endodontic treatment in permanent molars, diagnosed with irreversible pulpitis confirmed by a positive response to clinical, electrical sensitivity, and radiographic tests. Individuals participating in this research must provide a contact number (phone, cell phone, or social media username) to facilitate postoperative assessments. If a patient requires endodontic treatment for more than one tooth, the operator will follow the standard protocol; however, such cases will not be included in the study to avoid selection bias in the sample.	"Patients in any stage of pregnancy, those currently taking medication such as analgesics or anti-inflammatories at the time of treatment, immunocompromised individuals, or those with hypersensitivity to non-steroidal anti-inflammatory drugs will not participate in the study. These factors may alter pain perception or interfere with the analysis of post-treatment pain scores.

Patients with teeth presenting endodontic complications, such as calcifications, external or internal resorption, partial apex formation, dental perforations, longitudinal or vertical fractures, severe periodontal disease, or those undergoing treatment in multiple sessions, will also be ineligible for participation in this study. These factors can interfere with proper endodontic therapy and, consequently, with postoperative pain. Data from patients who cannot be contacted for postoperative pain assessment for any reason will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-8yzdphh	Effect of Exercise on sexual function in women with Endometriosis	Recruiting	Intervention	2024-04-29	<NULL>	<NULL>	7157	Effect of Pelvic Kinesiotherapy on sexual function in women with Endometriosis: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-08-02	Faculdade de Ciências da Saúde do Trairi	Faculdade de Ciências da Saúde do Trairi	https://ensaiosclinicos.gov.br/rg/RBR-8yzdphh	<NULL>	Women aged between 18 and 40 will be included in the study; with a clinical diagnosis of endometriosis in the report; and who are sexually active. In addition, participants who do not have an acute or terminal illness will be included; recent fracture in either upper or lower extremity; herniated disc; any chronic illness or orthopedic problems that interfere with your ability to participate in kinesiotherapy; epilepsy; cardiac arrhythmia; cancer; cognitive impairment; difficulty understanding instructions or using instruments; The volunteers included must not be undergoing any other type of treatment for sexual function related to endometriosis, with the exception of drug treatment	Participants who: voluntarily withdraw their consent will be excluded from the study; refuse to complete the assessment and reassessment protocols; do not participate in at least 75% of the scheduled meetings	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-10qgbdg3	Effect of Two Procedures for Dressing the Roof of the Mouth Evaluating Pain, Quality of Life and Healing in People Who Underwent Gum Grafting	Not yet recruiting	Intervention	2024-04-28	<NULL>	<NULL>	6974	Effect of different protective interventions of the palatal donor area on Healing, Pain and Quality of Life of individuals undergoing Epithelized Free Gingival Grafts: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal de Minas Gerais (UFMG)	Universidade Federal de Minas Gerais (UFMG)	https://ensaiosclinicos.gov.br/rg/RBR-10qgbdg3	<NULL>	Individuals aged 18 or over; systemically healthy or controlled American Society of Anesthesiologists (ASA) (ASA I / ASA II); with minimum palatal tissue thickness 2mm assessed with a University of North Carolina (UNC) periodontal probe; both genders	Smokers and alcoholics; individuals with altered coagulation, i.e., history of hemophilia, von Willebrand disease, or currently undergoing anticoagulant therapy; individuals with altered healing patterns, that is, decompensated type 2 Diabetes Mellitus; pregnant and breastfeeding women; individuals with a history of bacterial endocarditis; with continuous use of anti-inflammatories and corticosteroids; individuals who underwent gum grafting in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-342wxn9	Evaluation of the Clinical Impact of Different Telemedicine Practices in Intensive Care Units	Recruitment completed	Intervention	2024-04-27	<NULL>	<NULL>	6972	Evaluation of the Clinical Impact of Different Telemedicine Practices in Intensive Care Units: cluster randomized clinical trial (stepped-wedge or staggered implementation trial)_Telescope trial II	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-08	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-342wxn9	<NULL>	All patients admitted to the Intensive Care Units (ICUs) included (ICUs of public or philanthropic hospitals; ICUs with a minimum of 7 and a maximum of 20 beds; ICUs with a doctor and nurse available 24 hours a day and a physiotherapist available at least 18 hours a day). Patients aged 18 years or over. Both genders	Intensive Care Units (ICUs)with structured multidisciplinary round more than three times a week conducted by an intensive care physician (certified), documented in the medical record, with a fixed duration (&gt;5 min / patient), using some supporting tool (checklist or standard form), goal oriented, based on established protocols, including all the patients admitted to the ICU. Intensive care units already doing audit and feedback with specific planning. Dedicated coronary care units/cardiac intensive care units or other specialized units (cardiac surgery, neurological, burned patients). Step-down units or semi-intensive cardiac care unit. Intensive care units without availability of substitute renal therapy. ICU coordinator specialist in intensive care medicine and management training (MBA in Health Management or equivalent). Pacients admission for other reasons than medical (e.g., judicial cause, legal reasons, safety reasons). Patients previously included in the TELESCOPE II trial (for the primary outcome analysis)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:10
RBR-5pfj3f6	Impact of Cerebral Oximetry Monitoring on Postoperative Hemodynamic Outcomes in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass	Recruitment completed	Observational	2024-04-27	<NULL>	<NULL>	6973	Evaluation of Cerebral Oximetry in patients undergoing Cardiac Surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade do Extremo Sul Catarinense	Sociedade Literária e Caritativa Santo Agostinho	https://ensaiosclinicos.gov.br/rg/RBR-5pfj3f6	<NULL>	American Society of Anesthesiologists (ASA) physical status II or III; patients undergoing cardiac surgery; both genders	Urgent and emergency surgeries; use of intra-aortic balloon pump in surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-3xjwdbr	Use of technologies for distraction of children during dental care	Recruiting	Intervention	2024-04-26	<NULL>	<NULL>	6969	Use of Technologies for distraction in a university Pediatric Dentistry clinic	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Faculdade de Odontologia da Universidade Federal de Pelotas - UFPel	Faculdade de Odontologia da Universidade Federal de Pelotas - UFPel	https://ensaiosclinicos.gov.br/rg/RBR-3xjwdbr	<NULL>	Age between 6 and 10 years; both genders; overall good health; in need of restorative, endodontic, or extraction treatment	Children with physical disabilities that prevent the use of glasses and tablets or mental disabilities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-7dydc4h	Effects of early treatment of anterior open bite with orthodontic aligners and removable palatal crib	Recruitment completed	Intervention	2024-04-26	<NULL>	<NULL>	6970	Effects of early treatment of anterior open bite with orthodontic aligners and removable palatal crib: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-15	Universidade Anhaguera - UNIDERP	Universidade Anhaguera - UNIDERP	https://ensaiosclinicos.gov.br/rg/RBR-7dydc4h	<NULL>	Age between 7 and 10 years; Angle Class I malocclusion; anterior open bite (AOB) equal to or greater than 1 mm; erupted central incisors and upper and lower permanent first molars; both sexes	Presence of craniofacial deformities; absence of permanent teeth; severe crowding; posterior crossbite or previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-10gjt53p	Effect of online Psychotherapy on the quality of life of old people	Not yet recruiting	Intervention	2024-04-26	<NULL>	<NULL>	6971	Effectiveness of online Systemic Relational Psychotherapy for the quality of life of old people: clinical trial randomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-30	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-10gjt53p	<NULL>	Age between 60 and 80 years old; low quality of life in WHOQOL-bref; mild to moderate depressive symptoms on the GDS-15; access to the internet and digital technologies; live in the northern region of Rio Grande do Sul	Functional and/or cognitive impairment; hearing impairment; in psychotherapy; illiterate; failure to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-84vqcn6	Effect of D-Ribose L-Cysteine (RiboCeine) on oxidative stress markers and glutathione levels in healthy individuals	Recruitment completed	Intervention	2024-04-25	<NULL>	<NULL>	6966	Effect of D-Ribose L-Cysteine (Cysteine Ribose) on oxidative stress markers and glutathione levels in healthy individuals aged 40 to 59 years	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-10	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-84vqcn6	<NULL>	Healthy individuals; of both sexes; between the ages of 40 and 59 years	Individuals who use supplements to increase mitochondrial activity; nitric oxide; antioxidants or to reduce inflammation; and who have injuries that may make participation in the study difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-4xrx2g3	Reversal of muscle relaxation used in anesthesia: comparison of different doses of the reverser in children	Data analysis completed	Intervention	2024-04-25	<NULL>	<NULL>	6967	Comparison of the Effect of Different Doses of Neostigmine on Reversal of Rocuronium-Induced Neuromuscular Blockade in Children Undergoing General Anesthesia: Prospective Randomized Clinical Trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-04-01	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4xrx2g3	<NULL>	children aged 2 to 10; classified as American Society of Anesthesiologists (ASA) physical status I and II; undergoing general anesthesia for tonsillectomy with or without adenoidectomy	refusal to participate in the study; presence of renal disease; presence of hepatic disease; presence of neuromuscular disease; contraindication to the use of any of the drugs used in the study; body mass index equal to or greater than 30; acute clinical illnesses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-4ws3sb5	Effects of Vitamins B in Adult	Recruiting	Intervention	2024-04-25	<NULL>	<NULL>	6968	Evaluation of the Effects of Vitamins B on Adult Research Participants	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2023-02-06	Loema -  Instituto de Pesquisa Clínica e Consultores SS Ltda	Loema -  Instituto de Pesquisa Clínica e Consultores SS Ltda	https://ensaiosclinicos.gov.br/rg/RBR-4ws3sb5	<NULL>	Participants of both sexes; aged between 18 and 65 years; who have the capacity to understand and agree to participate in the study, indicating by signing the Free and Informed Consent Form approved by the Research Ethics Committee System; and agreeing to comply with the planned study procedures and to attend the visits; will be included in the study must be vitamin B12 deficient (serum cobalamin dosage &lt; 300 pg/mL), good health, determined by the absence of significant findings in medical history, physical examination, laboratory tests (biochemistry, hematology, and urinalysis), measurement of vital signs, and electrocardiogram results; participants who do not have reproductive potential should be checked for their current condition, such as: postmenopausal women (defined as 12 months or more of amenorrhea), hysterectomized women, oophorectomized women (bilateral) and/or have undergone tubal ligation (tubal ligation); the female participants must have childbearing potential who present a negative pregnancy test result on the day of administration of the first dose of the drugs of the study, as well as throughout the clinical trial; and agree on the use of safe contraception	Participants who have any clinical condition that, at the discretion of the investigator, may compromise participation in the study, and/or have difficulty swallowing solid medications; have a diagnosis of pernicious anemia or documented or suspected hemoglobinopathies; have a diagnosis of gastrointestinal disease that compromises the absorption of vitamin B12 administered orally (atrophic gastritis or Crohn&apos;s disease); have undergone bariatric surgery (partial or complete gastrectomy, or gastric reduction surgery); have undergone ileal resection or pancreaticopancreatical; have a documented or suspected diagnosis of pancreatic disease; or have undergone pancreatectomy; have undergone oral treatment with vitamin B12 (mecobalamin, hydroxycobalamin or cyanocobalamin) and/or multivitamins containing vitamin B12 in the last 30 days; or have been treated with injectable formulations containing vitamin B12 in the last 3 months; have chronic liver disease (documented or suspected) or current laboratory abnormality of liver enzymes; have chronic kidney injury requiring dialysis; have a history of myeloproliferative diseases or other neoplastic/metastatic diseases in the last 5 years; use levodopa, phenobarbital, phenytoin, primidone, pyrimethamine, valproic acid, hydantoin, aminosalicylates, aminoglycosides, colchicine, potassium in extended-release formulation, mesalazine, ascorbic acid, antibiotics, nitrates, fluorouracil, chloramphenicol, proton inhibitors, metformin, and biotin (vitamin B7); have a history of alcoholism (average alcohol intake of more than 3 drinks of alcoholic beverages in one day or more than 7 drinks of alcoholic beverages per week, for women, and more than 4 drinks of alcoholic beverages in one day or more than 14 drinks of alcoholic beverages per week, for men); or having ingested alcoholic beverages in the last week prior to the start of treatment; have a folate deficiency and/or having an iron deficiency; if the participant is pregnant, breastfeeding and/or intends to become pregnant during the study period; have hypersensitivity or contraindication to use of study drugs or chemically related compounds; have participated in clinical studies in the past twelve (12) months, unless there may be direct benefit to the research participant, at the discretion of the investigator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-9s6zpjs	Clinical aspects of  long-term follow-up of patients wtih Covid-19 after hospitalization in  HC-Unicamp	Recruitment completed	Intervention	2024-04-24	<NULL>	<NULL>	6958	Epidemiological and clinical-evolutionary aspects of a cohort of patients hospitalized with Covid-19 at HC-Unicamp	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-10	Universidade Estadual de Campinas	Hospital de Clínicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9s6zpjs	<NULL>	Patients of both sexes; greater than or equal to 18 years old; diagnosis of severe COVID-19 who have been hospitalised; post-discharge outpatient assessment, have dyspnoea at rest; or a distance covered in the six-minute walk test of less than or equal to 400 metres and or 80% of that predicted using a predictive reference equation; or a drop in peripheral oxygen saturation of greater than or equal to 4 points	Osteoarticular or cognitive limitations; or patients with a tracheostomy; or patients with previous respiratory or cardiovascular diseases that prevent the participant from performing the proposed tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-10ch623r	The first 6 months of life of newborns assisted with Preemietest equipment	Not yet recruiting	Observational	2024-04-24	<NULL>	<NULL>	6959	Morbidity in the first 6 months of life of newborns assisted with the Preemietest equipment: a cohort	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-08-01	Birthtech Dispositivos para a Saúde Ltda	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-10ch623r	<NULL>	NB from mothers; and the mothers themselves; and who delivered the baby; between the likely period of October 2023 to October 2024 (after ethical approval); in Units assisted with Preemiertest equipment	Malformation with structural changes to the skin; skin modifiers: anhydramnios; dropsy; congenital skin diseases or chorioamnionitis; newborns with congenital heart defects; patent ductus arteriosus; tachypnea not due to prematurity; and newborns with a clinical or laboratory diagnosis of infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-7pn5prj	Evaluation of Photodynamic Therapy in patients with Diabetes	Recruiting	Intervention	2024-04-24	<NULL>	<NULL>	6960	Evaluation of Chlorhexidine gel associated with Photodynamic Therapy in the treatment of Chronic Periodontitis in patients with Diabetes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-19	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-7pn5prj	<NULL>	Participants over 18 years old; type 2 diabetics;  periodontal disease with pockets with probing depth greater than 5 mm	hypersensitivity to the components of chlorhexidine gel or methylene blue and laser therapy and any evidence of systemic modifying factors of periodontal disease; except diabetics; osteoporosis types I and II; alcoholism; acquired or induced immunosuppression; any change described in the literature as potentially modifying the profile of periodontal disease; physical/emotional stress; medications that influence periodontal tissues. Samples from pregnant or lactating women; participants who have taken antibiotics in the last 6 months; clinical manifestations of oral candidosis; anti-inflammatories or hormone replacement therapy; and/or who have received periodontal treatment in the last six months prior to the procedure will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-7j4tfdg	The effect of use of Laser Therapy in Allergic Rhinitis: randomized clinical trial	Recruitment completed	Intervention	2024-04-24	<NULL>	<NULL>	6961	Effectiveness of use of Photobiomodulation Therapy in Allergic Rhinitis: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Pontifícia Universidade Católica do Paraná	Marco Aurelio Fornazieri	https://ensaiosclinicos.gov.br/rg/RBR-7j4tfdg	<NULL>	Patients between 18 and 59 years old; Confirmed diagnosis of allergic rhinitis by medical history and positive specific IgE test	Not completing the follow-up period; History of previous nasal surgery; History of antibiotic use for acute illnesses or purulent nasal secretions in the last 4 weeks prior to the start of the research; Ongoing/active upper airway infection (URTI); Inability to complete the test; Asthma; Anosmia; Nasofibroscopy with polyps; Incomplete high school; History of traumatic brain injury; Women with a UPSIT score less than or equal to 18; Men with a UPSIT score less than or equal to 16; Pregnant and breastfeeding women; Use of antihistamines in the last 30 days; Use of corticosteroids in the last 30 days; Use of vasoconstrictor in the last 30 days; Patients with psychiatric or neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-103n2zss	Effect of Exercise before and after Arteriovenous Fistula creation in patients with Doença Renal Crônica in the conservative stage: randomised clinical trial	Recruiting	Intervention	2024-04-24	<NULL>	<NULL>	6962	Effect of an Exercise Programm before and after Arteriovenous Fistula (AVF) creation for patients with Chronic Kidney Disease (CKD) in the conservative stage: randomised clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Hospital das Clínicas de Pernambuco	Programa de Pós-Graduação em Fisioterapia da Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-103n2zss	<NULL>	Men and women; aged between 35 and 70 years old; diagnosed with Chronic Kidney Disease (CKD) stage 4 and 5 with a Glomerular Filtration Rate (GFR)  less than or equal to 20 ml/min/1.73 m2, followed up in an outpatient clinic by conservative treatment, who already have an indication to create a radiocephalic Arteriovenous Fistula (AVF) to perform haemodialysis, and patients who have had a distal Arteriovenous Fistula (AVF) fittel	Patients with a previous history of brachiocephalic Arteriovenous Fistula (AVF); those who exercise regularly; a history of vascular surgery in the upper limbs; the presence of vascular access in the upper limbs; occupational activities involving the handling of heavy loads; the presence of traumatic injuries, orthopaedic and rheumatological injuries in the cervical spine, shoulders, elbows, wrists and hands; signs of thrombophlebitis; hypoplasia or agenesis of the upper limbs; presence of cognitive impairment that makes it difficult to understand and finalize the assessment methodology and treatment protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-2cr7h9f	The Effects of Photobiomodulation in children with autism: a randomized controlled clinical trial	Not yet recruiting	Intervention	2024-04-24	<NULL>	<NULL>	6963	Effect of Photobiomodulation In children with Autism Spectrum Disorder: a randomized and controlled clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-05-06	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2cr7h9f	<NULL>	Children aged between 3 and 12 years; both sexes; diagnosed with Autistic Spectrum Disorder, regardless of the degree of severity, gender, race, ethnicity or type of treatment they are undergoing	Are undergoing medical treatment and using medications for non-Autism Spectrum Disorder-related pathologies (e.g., diabetes, cancer, epilepsy). Have any comorbidity that prevents the use of Photobiomodulation (photosensitivity or other conditions).  Discontinue the ongoing conventional multiprofessional treatment at Comprehensive Care Program for Children and Adolescents - PAICA or initiate a new treatment during the study. Have had an unstable medical condition in the last thirty days. Interrupt the treatment for more than one week or miss more than two Photobiomodulation sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-2b2prdz	Acute responses of the Cardiovascular System in elderly people with high blood pressure submitted Plyometric Exercise	Recruiting	Intervention	2024-04-24	<NULL>	<NULL>	6964	Acute responses of Systemic Blood Pressure and Cardiac Autonomic Modulation in hypertensive elderly people subjecting to Plyometric Exercise	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Instituto Multidisciplinar de Reabilitação e Saúde - Universidade Federal da Bahia - UFBA	Faculdade de Educação FACED - Universidade Federal da Bahia UFBA	https://ensaiosclinicos.gov.br/rg/RBR-2b2prdz	<NULL>	Women; minimum age 60 years old; diagnosis of arterial hypertension; use antihypertensive medication with a maintained dose for the last 4 months;  do not present secondary arterial hypertension and/or target organ damage; do not use medications that directly affect cardiac autonomic regulation (e.g. beta blockers and non-dihydropyridine calcium channel inhibitors); do not present other cardiovascular diseases; do not present class 2 obesity or higher; do not have diabetes with complications or use insulin;  do not present orthopedic damage that hinders the practice of resistance training	Resting systolic blood pressure above 160 mmHg and/or Diastolic Blood Pressure above 105 mmHg; missing collection days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-10gq99m4	Effect and safety of using a mixture of live bacteria that are beneficial to health to treat people with constipation and/or diarrhea and/or Irritable Bowel Syndrome	Recruiting	Intervention	2024-04-24	<NULL>	<NULL>	6965	Double-blind, Randomized, Placebo-Controlled Clinical study of the performance and safety of using a Mixture of Probiotic Strains in the treatment of Changes in Bowel Habits and Associated Symptoms	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Farmoquímica S/A DIVCOM S/A	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10gq99m4	<NULL>	Aged between 18 and 60 years; diagnosed with constipation or diarrhea or Irritable bowel syndrome as per Rome Foundation &quot;Rome IV&quot; criteria (Appendix 3); BMI between 18.5 and 29.9 Kg/m2.	Severe psychiatric diagnoses; confirmed medical diagnoses of gastrointestinal tract disorders (such as Crohn&apos;s disease and ulcerative colitis; celiac disease;  small intestinal bacterial overgrowth); type I or II diabetes mellitus; history of gastrointestinal surgery; conditions that are known to cause changes in the gut microbiota (for example, opioid use, drug or alcohol abuse); if they are pregnant; breastfeeding; undergoing cancer treatment; taking laxatives; recently use of (in the last three months) probiotics (except for dairy and yogurt consumption) or symbiotics;  other medications or supplements that are known to affect intestinal movement (for example, antispasmodics, antidepressants, antacids); antibiotics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:03
RBR-3dncdr5	Effects and safety of a Lung Expansion Therapy protocol in patients with artificial airway admitted to intensive care units: randomized clinical trial	Recruiting	Intervention	2024-04-22	<NULL>	<NULL>	6953	Efficacy and safety of a Lung Expansion Therapy protocol in tracheostomized patients undergoing spontaneous ventilation in the intensive care unit: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-10	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-3dncdr5	<NULL>	Tracheostomized patients undergoing spontaneous ventilation; age greater than or equal to 18 years; of both sexes; with Maximum inspiratory pressure (PImax) less than minus 30; with pathologies of different etiologies; with prolonged bed rest (more than 14 days); admitted to an intensive care unit	Patients who present progressive worsening of the clinical condition; shock; fracture in the chest region; pneumothorax; Immediate postoperative period of abdominal surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-3z3fcdk	Assessment of Anxiety in Dental Surgeries	Recruitment completed	Intervention	2024-04-22	<NULL>	<NULL>	6954	Assessment of Anxiety in Third Molar Surgery Controlled split-mouth clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-05	Instituto de Ciência e Tecnologia - Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Instituto de Ciência e Tecnologia - Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-3z3fcdk	<NULL>	Patients requiring extraction of bilateral lower third molars; of both genders; aged between 15 and 40 years; bilateral teeth, 38 and 48 with the same inclusion classification as Winter, Pell and Gregory; participate voluntarily; sign the Free and Informed Consent Form	Patients with systemic diseases, hypertensive, diabetic, depressive, cardiac; with the use of medications for anxiety, depression, panic syndrome; using anti-inflammatory drugs in the last 15 days; with the use of analgesics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-33wrhzd	Use of Probiotics in prevention of Chemotherapy induced diarrhea in patients with gastrointestinal Cancer	Recruitment completed	Intervention	2024-04-22	<NULL>	<NULL>	6955	Evaluation of use of Probiotics in prevention of Irinotecan and/or Fluoropyrimidines induced Diarrhea in patients with gastrointestinal tract Cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-15	Universidade Federal de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-33wrhzd	<NULL>	Age between 18 and 85 years old;  Diagnosis of primary gastrointestinal tract tumor  (esophagus, stomach, pancreas, colon and rectum); Planning to start chemotherapy treatment with chemotherapy protocols containning irinotecan and/or fluoropyrimidines; Performance scale according to the Eastern Cooperative Oncology Group (ECOG) between 0-2	Severe systemic diseases including heart disease, coagulopathies, renal and hepatic dysfunction; History of severe diarrhea during previous treatment; Use of probiotics, prebiotics up to 2 months before recruitment; Pregnant and lactating women; Incapable patient; Not signed the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-3gpm324	The effect of Zumba and electronic movement games on Anxiety levels	Not yet recruiting	Intervention	2024-04-22	<NULL>	<NULL>	6956	The influence of Zumba through the Exergame compared to the traditional form on the Anxiety	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-3gpm324	<NULL>	Young people of both sexes; aged between 18 and 39 years old; have anxiety according to the State-Trait Anxiety Inventory questionnaire	Participants who have a low level of anxiety;  participants that use any type of anxiolytic or antidepressant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-6dtfb2r	Study of treatment with Shockwaves in patients with Chronic Pain in the Lumbar Spine	Recruiting	Intervention	2024-04-22	<NULL>	<NULL>	6957	Use of Shock Waves in the treatment of Chronic Low Back Pain - prospective, randomized, double-blind clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-03	Departamento de Anestsiologia da Faculdade de Medicina de Botucatu	Clinica Ortofisio Ltda	https://ensaiosclinicos.gov.br/rg/RBR-6dtfb2r	<NULL>	Age group between 30 and 80 years old; of both genders; diagnosed with musculoskeletal chronic low back pain for more than one year, without improvement with conservative treatment, and scores of pain intensity in , at least 20%, considering the Oswestry Disability Index (ODI), and pain intensity &gt;5, considering the Numerical Visual Scale (VSN); all patients must be on stable doses (at least 10 days) of medications used to treat their low back pain at the time of enrollment in the study	Patients who present easily identifiable cognitive alterations; as well as those undergoing psychiatric treatment in which their illness is not in remission; individuals who have an indication for surgery or who have previously undergone surgery on the lumbar spine; pregnancy; coagulopathy and/or use of anticoagulants; systemic infections; presence of skin ulcers; presence of vessels at the treatment site; malignant neoplasms; cardiac arrhythmias and/or use of pacemakers; and epilepsy; patients with a diagnosis of fibromyalgia and a neuropathic component in their low back pain, diagnosed by DN4	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-68mzg3c	Assessment of Sedation in the intensive care unit (ICU): monitoring patients level of consciousness	Recruiting	Intervention	2024-04-18	<NULL>	<NULL>	6948	Use of the consciousness monitor to evaluate Sedoanalgesia in an intensive care unit	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Patrícia Nunes dos Santos	Hospital Universitário da Universidade Federal do Piauí- HUUFPI	https://ensaiosclinicos.gov.br/rg/RBR-68mzg3c	<NULL>	Age over 18 years old; female and male sex; mechanical ventilation via endotracheal tube; using continuous intravenous sedation at doses above those recommended	Primary neurological disorders (stroke, hypoxic brain injury, intracranial hemorrhage and traumatic brain injury); use of neuromuscular blockers; infection in the central nervous system; extubation; hemodynamic instability; hypoxia; palliative care; post-myocardial revascularization surgery; refusal of the patient or family member to participate; death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-95nvnn8	The importance of educational videos in the level of knowledge and understanding of oral health in caregivers	Recruiting	Intervention	2024-04-18	<NULL>	<NULL>	6949	Effect of an educational intervention on the oral health literacy of caregivers: A multicenter randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal de Santa Maria	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-95nvnn8	<NULL>	We will consider caregivers at least 18 years old of children aged 0 to 12 who are seen at the university&apos;s pediatric dentistry clinics; who are Brazilian, or who have Brazilian Portuguese as their mother tongue; without visual or cognitive alterations that make it impossible for them to read; who have smartphones with internet access and the WhatsApp Messenger app; and who agree to participate in the study and sign the Informed Consent Form	Illiterate caregivers; caregivers who are not native speakers of Portuguese or who have learning difficulties; caregivers with vision or hearing problems (reported or perceived); or caregivers with cognitive problems that prevent them from answering the questionnaires will not be considered eligible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-8vfxfqd	Role of Physical exercise on inflammation and obesity	Recruiting	Intervention	2024-04-18	<NULL>	<NULL>	6950	Role of Physical exercise on NLRP3 inflammation and Obesity biomarkers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Santo Amaro	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8vfxfqd	<NULL>	The study includes obese; previously sedentary individuals; divided into two groups: one group that undergoes physical exercise for eight weeks (three times a week) and the other group that is not trained (control)	Diabetics; those using statins; those who are seropositive for HIV, hepatitis C virus (HCV) or hepatitis B (HBV) and/or another systemic disease; those undergoing treatment for obesity; who have undergone bariatric surgery; participants in another regular health program are excluded; did exercises (such as, for example, aerobic and/or strength training) in the six months prior to the start of the experimental period; people with severe motor disabilities, musculoskeletal injuries, severe respiratory diseases, heart diseases (severe heart failure, cerebrovascular disease, severe cardiopulmonary dysfunction, acute myocardial infarction or initial phase of rehabilitation, untreated malignant arrhythmias, untreated severe hypertension, pulmonary hypertension severe), stroke or neurological disease, symptomatic cardiac malformations (such as septal defects, patent ductus arteriosus or valvular stenosis); volunteers who attend less than 80% of the training days; participants do not complete the training session on 3 consecutive days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-1034kxcw	Effect of Respiratory Muscle Training on respiratory muscle strength and exercise resistance in patients with Acute Heart Failure in the hospital phase of cardiac rehabilitation	Not yet recruiting	Intervention	2024-04-18	<NULL>	<NULL>	6951	Effect of Inspiratory Muscle Training on Inspiratory Muscle Strength and Exercise Resistance in a Patient with Acute Heart Failure	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-24	Hospital de Clínicas da Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-1034kxcw	<NULL>	Patients diagnosed with heart failure; ventricular ejection fraction less than 40 percent; aged greater than or equal to 18 years; hospitalized for decompensated heart failure and clinically stable without the need for continuous ventilatory support	Decompensated lung diseases, pregnancy, head trauma, brain injury, cognitive impairment, neuromuscular disorders, hemodynamic instability with high dose of inotropes or acute coronary syndrome, presence of physical limitation that limits the performance of assessments and those who do not agree to sign the term of free and informed consent. Hemodynamic instability will be considered if systolic blood pressure is less than 90 mmHg or mean arterial pressure is less than 65 mmHg, peripheral hypoperfusion, heart rate is less than 40 or greater than 130 beats per minute, SpO2 is less than 88%, recent episodes of vomiting, complaints of dizziness or headache, high dose of dobutamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-83hc4bw	Effects of mate tea ingestion (Ilex paraguariensis) before aerobic exercise on metabolic, muscle damage and oxidative stress indicators	Data analysis completed	Intervention	2024-04-17	<NULL>	<NULL>	6944	Effect of ingesting mate tea (Ilex paraguariensis) before exercise on energy metabolism and metabolic indicators	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-02-22	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-83hc4bw	<NULL>	Male; age between 18 and 35 years; regular practitioner of aerobic exercise; absence of metabolic diseases; no aversion or intolerance to study foods; not a user of tobacco, alcohol, supplements, or medications	Negative response to all questions in the Pre-activity Readiness Questionnaire (PAR-Q); below-average coronary risk; body fat percentage less than 25%; and Body Mass Index between 18.5 and 24.9 kg/m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-2ymnqrr	Pain during filling using Tagger&apos;s Hybrid Technique in Endodontic Treatments	Data analysis completed	Intervention	2024-04-17	<NULL>	<NULL>	6945	Pain during filling using Tagger&apos;s Hybrid Technique in Endodontic Treatments of necroses teeth in a single session, considering in association demographic data, dental group, periradicular status, treatment time and extravasation of filling cement	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-10	Associação Paranaense de Cultura - APC	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2ymnqrr	<NULL>	Patients with asymptomatic necrotic teeth with or without periapical lesions visualized radiographically, referred for endodontic treatments at the Dental Specialties Center of the Municipality of Navegantes – CEO/Navegantes – between the months of May 2023 to August 2023, after coronary access carried out in Basic Health Units (UBSs) through the use of spherical drills. 1014 or 1016, later using Tricresolformalin as an indwelling dressing. Age equal to or greater than 18 years old. Both genders	Patients with coronary and/or root perforations; periodontal involvement; spontaneous and/or acute or moderate painful symptoms upon percussion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-86qd34n	Orientations on dental trauma in schools: an intervention study	Recruitment completed	Intervention	2024-04-17	<NULL>	<NULL>	6946	Orientations on dental avulsions in schools: an intervention study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Programa de Pós-graduação Strictu Sensu Odontolgia da Atitus Educação	Programa de Pós-graduação Strictu Sensu Odontolgia da Atitus Educação	https://ensaiosclinicos.gov.br/rg/RBR-86qd34n	<NULL>	Elementary schools that have teachers consent to their participation through the Free and Informed Consent Form.	Teachers who are in training or interns will be excluded from the analysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-38c5f2h	Effectiveness of using a Customizable Healing Device for dental Implants: a Clinical Trial	Data analysis completed	Intervention	2024-04-17	<NULL>	<NULL>	6947	Effectiveness of using a Customizable Healing Device for Immediate Implants in the posterior region: a Randomized Clinical Trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-05-14	Fundação Universidade de Passo Fundo	Fundação Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-38c5f2h	<NULL>	Being indicated and extraction of posterior teeth and installation of dental implants; participants agree and sign the consent form; being in satisfactory health conditions to undergo treatment	Participants do not agree or do not sign the consent form; not being in systemic health conditions to carry out the treatment; failure to meet technical conditions for immediate dental implant installation after extraction. Teeth with furcation lesion or loss of gingival papillae will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-7v33r6x	Assessment of the impact of using more affordable Videolaringoscopes in airway management	Not yet recruiting	Intervention	2024-04-16	<NULL>	<NULL>	6940	Evaluation of the impact of the use of 3d printed Videlaryngoscopes on airway management	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-10	Hospital Santa Izabel - Santa Casa da Misericórdia da Bahia / Professor Doutor Celso Figueirôa	Instituto de Ensino e Simulação em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7v33r6x	<NULL>	Doctors participating in the advanced cardiology life support course at Health Education and Simulation Institute; who agree to the study and sign the Free and Informed Consent Form	Refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-9gccx5c	Relationship between gut and brain in elderly with Mild Cognitive Impairment and Alzheimer Disease from Brazil southern	Recruitment completed	Intervention	2024-04-16	<NULL>	<NULL>	6941	Gut-Brain axis signaling in individuals with Mild Cognitive Impairment and Alzheimer&apos;s Disease from Brazil southern	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-22	Universidade do Extremo Sul Catarinense	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-9gccx5c	<NULL>	Individuals of both sexes, who use the SUS, residents of municipalities in the South of Brazil; individuals who agree to participate in the study and sign the Informed Consent Form (TCLE); age equal to or greater than 60 years; oral route of feeding; cognitive level that allows questionnaires to be carried out; residents in the municipality of Criciúma and treated at the Centro and Rio Maina Basic Health Units or also at the UNESC geriatrics outpatient clinic; residents in long-term care institutions in municipalities in the South of Brazil	Partial (40 to 60% impairment) or total visual impairment; severe hearing impairment (cannot hear sounds below 80 decibels, on average) and deep (when you do not hear sounds emitted with an intensity lower than 91 decibels); diagnosis of general psychiatric disorders; not being able to answer the questionnaires independently; having diseases in the gastrointestinal tract, mainly diseases related to the intestine; neurological diagnosis compatible with syndromes or malformations; other neurological events that may cause changes in swallowing; being using antibiotics; recent viral infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:01
RBR-7zrm8fd	Assessment of the bowel from women that underwent surgery for intestinal endometriosis	Recruiting	Observational	2024-04-16	<NULL>	<NULL>	6942	Intestinal functional evaluation of women undergoing surgical treatment for deep Intestinal Endometriosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Irmandade da Santa Casa de Misericórdia de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7zrm8fd	<NULL>	Female patients; with clinical and radiological suspicion of deep endometriosis with intestinal involvement, who underwent imaging investigation using transvaginal ultrasound with intestinal preparation to map the endometriosis or Nuclear Magnetic Resonance Imaging with the same intestinal preparation technique; and had suspected intestinal involvement under 4 cms; with a degree of circumference in the intestinal involvement less than 40% and with a distance from the lesion less than 15 cms from the anal verge	Patients who do not present clinical and diagnostic characteristics in the evaluation that include them in the indications for the lumpectomy technique; the impossibility of completing the questionnaire within the allotted time (PRE, P3, P6 and P12); failure to complete the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-6wjfmm7	Melatonin and how the body uses and transforms energy from food in Autism Spectrum Disorder	Data analysis completed	Intervention	2024-04-16	<NULL>	<NULL>	6943	Melatonin and energy metabolism in Autism Spectrum Disorder	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2016-12-01	Universidade Federal de São Paulo UNIFESP	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6wjfmm7	<NULL>	Patients with Autism Spectrum Disorder diagnosed according to the diagnostic criteria defined in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders; male gender; aged between ten and sixteen years and eleven months; patients using antipsychotic medication for at least one month; patients with mild intellectual disability with a global intelligence quotient between sixty nine and fifty or moderate intellectual disability with a global intelligence quotient between forty nine and thirty five	Patients who modified or discontinued psychotropic medication during the study; patients currently using melatonin or having used it within the last month; patients currently using medications from the beta blocker class and or currently using any benzodiazepine; patients diagnosed with amaurosis; patients diagnosed with early puberty; patients diagnosed with type one diabetes and or hypothyroidism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-10g8337t	Evaluation of brain therapy for the treatment of Alzheimer&apos;s	Recruiting	Intervention	2024-04-16	<NULL>	<NULL>	8260	Evaluation of Brain Pulse Therapy for the Treatment of Alzheimer&apos;s	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2025-05-15	Universidade Federal do ABC	Scientia Especialidades Médicas LTDA	https://ensaiosclinicos.gov.br/rg/RBR-10g8337t	<NULL>	Patients with Alzheimer&apos;s disease according to the criteria of the National Institute on Aging – Alzheimer&apos;s Association (NIA-AA) and corroborated by cerebrospinal fluid biomarkers (decreased beta-amyloid, increased phosphorylated tau protein). Age 18 years or older. Both birth sexes. Classified by the Clinical Dementia Rating (CDR) scale as mild or moderate stage (CDR 1 or 2). On a stable dose of cholinesterase inhibitors (donepezil, rivastigmine, or galantamine) for at least four months. With treated depression, provided they are on a stable dose of antidepressants and in a euthymic state	Presence of relevant intracerebral pathologies, including vascular lesions with Fazekas score greater than 2, not related to Alzheimer&apos;s Disease (AD). Non-compliance with the protocol. Blood coagulation disorders. Use of oral anticoagulants. Treatment with corticosteroids in the last six weeks. Pregnancy. Breastfeeding. Epilepsy. Untreated depression. Score equal to or greater than 5 on the Geriatric Depression Scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-4s62j8t	Factors associated of Influence on Tinnitus	Not yet recruiting	Observational	2024-04-15	<NULL>	<NULL>	6933	Factors associated with the level of Somatosensory influence on Subjective tinnitus	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4s62j8t	<NULL>	Both genders; age between 18 and 60 years old; with tinnitus	Under 18 years old; over 60 years old; cognitive difficulty; degenerative neurological disease; moderate to severe hearing loss; history of psychiatric hospitalization; volunteers who bring information considered dubious; volunteers who withdraw their consent to participate; who develop some of the conditions foreseen in the non-inclusion criteria or another medical condition judged by the investigator as impeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-6jsp9fs	Acceptability, feasibility, and efficacy of an online individual intervention on Mindfulness and Trial-based Cognitive Therapy for the well-being of the judiciary	Recruiting	Intervention	2024-04-15	<NULL>	<NULL>	6934	Acceptability, feasibility, and efficacy of an online individual intervention based on Mindfulness and Trial-based Cognitive Therapy for the psychological well-being of judges and public servants in the judiciary	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-30	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6jsp9fs	<NULL>	adults of both sexes; employees; or judges of TRT5; aged 18 years or older; with a score of 7 or more on the SRQ-20. Participants should be able to read, write, and follow instructions and must have internet access	self-declaration of severe symptoms of any mental disorder or ongoing organic disease; having a personality disorder; a diagnosis of schizophrenia; psychotic disorder; suicidal ideation; or drug use causing cognitive impairments in attention and concentration; being in the early stages or adjusting to pharmacological and/or psychotherapeutic treatment; and being a regular practitioner of mindfulness, meditation, or similar practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-7dx3k4h	Pain after treatment with the use of TruNatomy and XP-endo Shaper instruments: clinical trial	Recruitment completed	Intervention	2024-04-15	<NULL>	<NULL>	6935	Postoperative pain after using the TruNatomy and XP-endo Shaper systems: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7dx3k4h	<NULL>	Patient with physical status classified as ASA I (American Society of Anesthesiologist); vital permanent posterior teeth (diagnosis of normal pulp); no symptoms; maxillary or mandibular, premolar or molar; indication of conventional endodontic treatment for prosthetic indication; age 18 or over; both genders	Non-vital teeth; apical periodontitis; endodontic retreatments; symptomatic/asymptomatic irreversible pulpitis; root resorption; teeth with incomplete rhizogenesis; root canal in which the patency of the apical foramen cannot be established; patients who refused to participate in the study; patients in whom the tooth cannot be treated in a single session; patients using any type of medication (analgesics or anti-inflammatories, hormonal or non-hormonal) during the seven days prior to treatment; patients with signs of systemic infection; patients allergic to local anesthetic agents; patients with systemic diseases; decompensated; patients allergic to Sodium Hypochlorite; patients with cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-3qzk3nw	Characteristics of root canal instrumentation with enlargement of the apical foramen	Recruiting	Intervention	2024-04-15	<NULL>	<NULL>	6936	Morphological, microbiological and immunological characteristics of foraminal enlargement: randomized clinical trial and ex vivo study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3qzk3nw	<NULL>	Patients aged 18 years or over; of both sexes; diagnosed with pulp necrosis and apical periodontitis in upper or lower first and/or second molars	Use of some antibiotics and anti-inflammatory drugs in the three months before endodontic therapy; those who have already started instrumentation of the canals previously and/or present concomitant periodontal involvement in the tooth in question; teeth with root fractures, fused roots, incomplete rhizogenesis, wide foramina whose initial apical instrument in the MV canal is greater than K #20	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-3srpth8	Strength exercise, cognitive stimulation and type 2 Diabetes on aging	Recruiting	Intervention	2024-04-15	<NULL>	<NULL>	6937	Dual-Task Resistance Exercise: investigation of the influence on cognitive performance, functional capacity, quality of life, and glycemic control in older adults with type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Pará	Laboratório de Investigações em Neurodegeneração e Infecção	https://ensaiosclinicos.gov.br/rg/RBR-3srpth8	<NULL>	Volunteers diagnosed with type 2 diabetes mellitus undergoing regular medical follow-up; both genders; minimum age of 60 years; have medical clearance to practice physical activity; normal performance, adjusted for education, on the Mini-Mental State Examination (MMSE); minimum visual acuity of 20/30, with or without corrective lenses	Diagnosis of cardiovascular and osteoarticular diseases that make it impossible to carry out the intervention program or that may be worsened by exercise; have participated in a structured physical training program in the last three months; have a neurodegenerative disease, traumatic brain injury and/or history of a stroke; Inability to walk 3 meters; in use of cholinesterase inhibitors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-5r9xzbq	An Exergames or PhysicalEducation bouts benefits subsequent inhibitory control in Autism Spectrum Disorder children	Data analysis completed	Intervention	2024-04-15	<NULL>	<NULL>	6938	Acute effects of Exergames on the executive function of children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Católica de Brasília	Escola Classe 10 de Taguatinga	https://ensaiosclinicos.gov.br/rg/RBR-5r9xzbq	<NULL>	Those enrolled at Escola Classe 10 in Taguatinga/DF who were diagnosed with Autism Spectrum Disorder (ASD) according to the Diagnostic and Statistical Manual of Mental Disorders - DSM-5 (APA, 2014). No history of diseases such as physical, pulmonary or cardiac malformations. Boys and girls aged between 6 and 12	Non-verbalized Autism Spectrum Disorder (ASD); with intellectual impairment (IQ below 70); ages below 6 and above 12 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-77sqd4z	Study with cancer patients followed at the Cecon Foundation Pain Therapy and Palliative Care Service to analyze whether a Meditation intervention using Virtual Reality glasses will alleviate Pain and improve patients&apos; quality of life	Not yet recruiting	Intervention	2024-04-15	<NULL>	<NULL>	6939	Study with cancer patients followed at the Pain Therapy and Palliative Care Service of Fundação Cecon: an analysis of quality of life and the impact of a Meditation intervention with Immersive Virtual Reality for pain relief	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-11	Fundação Centro de Controle de Oncologia do Estado do Amazonas - FCECON	Fundação Centro de Controle de Oncologia do Estado do Amazonas - FCECON	https://ensaiosclinicos.gov.br/rg/RBR-77sqd4z	<NULL>	Be monitored at the  Pain Therapy and Palliative Care Service (STDCP) to control symptoms arising from any type of neoplasia at any stage; a diagnosis of chronic pain recorded in the medical record; both genders, male and female; be between 18 and 75 years old on the date of the first collection; able to understand Portuguese (read and write); normal vision and hearing; have an Android cell phone; able to perform movements with the head and with sufficient motor control to perform body movements; agree to participate in the study and sign the Free and Informed Consent Form (ICF)	Patients of the indigenous race, due to cultural, linguistic peculiarities and legislation special; patients with records of serious psychiatric illnesses in the medical record from Diagnostic and Statistical Manual of Mental Disorders  (DSM-5), schizophrenia, schizotypal disorders, delusional disorders, borderline and dementia; impairment of the ability to understand or communicate based on the researcher&apos;s assessment; report of discomfort with the use of Immersive Virtual Reality; progression of the disease with the limitation of maintaining the proposed regular outpatient return; patients with brain tumors, brain metastases, or past history of seizures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-9v9r6vj	Evaluation of Cardioprotective Nutrition in people with Metabolic Syndrome and High Blood Pressure: a randomized clinical trial	Recruiting	Intervention	2024-04-12	<NULL>	<NULL>	6931	Evaluation of the effectiveness of Cardioprotective Nutrition in patients with Metabolic Syndrome and High Blood Pressure: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-26	Universidade do Estado da Bahia - UNEB	Universidade do Estado da Bahia - UNEB	https://ensaiosclinicos.gov.br/rg/RBR-9v9r6vj	<NULL>	Adults and elderly people. Both sexes. Minimum age of 20 years. Diagnosis of hypertension (140 and/or 90 mmHg). Patients with metabolic syndrome. based on the IDF diagnosis (International Diabetes Federation, 2006)	"Pregnant women;nursing mothers; patients with severe heart failure;undergoing gastroplasty;with liver and/or kidney failure;previous history of encephalopathy or anasarca;with any and all neurocognitive conditions or with mental disorders (defined by their clinical history) will not be included in the research. or in clinical investigation); transplanted patients;patients with gastroplasty and those who have a life expectancy equal to or less than 6 months (eg those with malignant metastasis); wheelchair users, patients undergoing treatment for all and
any type of cancer and those with difficulties to feed orally"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-829dqnf	Application of Elastic Bandage after Breast Equality Surgery: Randomized Clinical Trial - Breastaping II	Recruiting	Intervention	2024-04-12	<NULL>	<NULL>	6932	Application of Taping in the Intraoperative period of Symmetrization Surgery after treatment for Breast Cancer: Randomized Clinical Trial – Breastaping II	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-11	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-829dqnf	<NULL>	be female; individuals aged 18 ato 70; having been diagnosed with breast cancer; have an indication for surgical treatment to symmetrize the breasts; understand the objectives and instruments used in the research	have an allergy to the taping tape; have neurological diseases (e.g. Parkinson&apos;s Disease, Multiple Sclerosis, etc.); present psychological disorders that impede understanding of the research and assessment instruments; being undergoing surgical treatment for recurrence of breast cancer; Participants who develop infections, hemorrhages, hematomas or other complications (except scar dehiscence) in the P.O. period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-5q5g4s6	Analysis of biceps and triceps brachii muscle activity during elbow flexion and extension movements using Pilates breathing with different loads: a clinical trial	Not yet recruiting	Intervention	2024-04-10	<NULL>	<NULL>	6929	Electromyographic analysis of the biceps and triceps brachii muscles during elbow flexion and extension movements using the Pilates method breathing technique in different load settings: a clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5q5g4s6	<NULL>	Participants must be healthy individuals of both sexes; aged between 18 and 25 years; with no experience with the Pilates method	Participants who do not sign the informed consent form; who cannot attend a second data collection session; who are unable to perform the Pilates method technique; who cannot remain in an upright position; who are unable to perform flexion and extension movements of the curves; who have undergone surgical procedures that prevent the protocol from being performed; who have recent injuries in the elbow region; who show signs and symptoms of inflammation; who have a high degree of muscle imbalance between the upper limbs; who have serious neurological, cardiorespiratory, or metabolic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:04
RBR-6htr5rg	Gluten and casein restriction and its relationship with anxiety disorder: nutritional, metabolic and electrophysiological repercussions	Recruitment completed	Intervention	2024-04-09	<NULL>	<NULL>	6928	Impact of restriction of potentially allergenic foods and its relationship with anxiety: nutritional, behavioral and electrophysiological effects	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6htr5rg	<NULL>	Be between the ages of 18 and 55; of both genders; be undergraduate and/or graduate students and/or education professionals in a situation of regency or administrative burden in the public or private education network	Having a diagnosis of food allergy, such as being celiac; pre-existing medical-nutritional follow-up; body mass index (BMI) ≤ 18.4 and ≥ 40, as these are extremes that may cause bias in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-26ymzkc	Pulverize Yam (D. Cayennensis) supplementation in the treatment of Gestational Diabetes Mellitus	Not yet recruiting	Intervention	2024-04-08	<NULL>	<NULL>	6925	Therapeutic perspective of Gestational Diabetes Mellitus with Yam Pulverize supplementation (D. Cayennensis)	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-26ymzkc	<NULL>	Voluntary pregnant women with Gestational Diabetes Mellitus treated at the Lauro Wanderley University Hospital; over age	Pregnant women who are allergic to yams will be excluded; patients with kidney diseases; patients with liver or neurological diseases; pregnant women using multiple medications; minors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-377gqvx	Evaluation of the efficiency of a device for cramps resulting from oncological treatments	Data analysis completed	Intervention	2024-04-08	<NULL>	<NULL>	6926	Evaluation of the efficiency of an ionic load reduction device for Cramps arising from Chemotherapy-induced Peripheral Neuropathy (CIPN) and/or treatments inducing muscle ion overload and abrupt pH changes: a double-blind, randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-22	Associação de Combate ao Câncer de Goiás - ACCG	Associação de Combate ao Câncer de Goiás - ACCG	https://ensaiosclinicos.gov.br/rg/RBR-377gqvx	<NULL>	Patients of both genders; with Chemotherapy-Induced Peripheral Neuropathy (CIPN); and/or treatments causing an excess of ions in the muscles and abrupt changes in pH	Cramps related to the sciatic nerve; or a previous history of cramps; or weak and intermittent cramps	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-7rhyzhd	Evaluation of pain after endodontic treatment (root canal) with mechanized files	Recruiting	Intervention	2024-04-08	<NULL>	<NULL>	6927	Postoperative pain, quality of life and incidence of instrument fractures after Endodontic preparation with rotary and reciprocating endodontic instruments after second use: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Centro Universitário do Maranhão – UNICEUMA	Centro Universitário do Maranhão – UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-7rhyzhd	<NULL>	Patients of both genders; age between 18 and 50 years; diagnosed with pulp alteration with indication of radical endodontic treatment in molars	Patients younger than 18 years old or over 50 years old. With report of pain or with visible periapical lesion on periapical radiography. Presence of internal or external resorption. Trismus. Ankylosis. Periodontal condition index less than 3. Systemic disease. Tooth positioning out of normal alignment. History of trauma. Pregnancy. Anterior teeth. Lack of patient compliance. Presence of teeth that require endodontic retreatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-10shkvkk	Desensitizing agents in the treatment of dentin hypersensitivity	Recruiting	Intervention	2024-04-06	<NULL>	<NULL>	6923	Influence of active and passive application of desensitizing agents in the treatment of dentin hypersensitivity	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de Uberlândia	Escola técnica de Saúde - ESTES	https://ensaiosclinicos.gov.br/rg/RBR-10shkvkk	<NULL>	Patients with Dentin Hypersensitivity; individuals interested in Dentin Hypersensitivity treatment; agree to participate and sign the informed consent form (ICF); participants aged between 18 and 60 years; both genders	Presence of caries or unsatisfactory restorations causing dentin sensitivity; patients undergoing orthodontic, periodontal treatment, or dental bleaching process; presence of severe bruxism and loss of vertical dimension; presence of spontaneous tooth pain, indicating pulpitis; maintenance of inadequate oral hygiene; diagnosis of periodontal disease; users of extensive dental prostheses; pregnant or lactating women; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-10kbw6nx	Postoperative pain and quality of life after Canal Treatment with mechanized instruments: clinical study	Recruitment completed	Intervention	2024-04-06	<NULL>	<NULL>	6924	Postoperative pain and quality of life after Endodontic Preparation with Protaper Ultimate and Reciproc Blue instruments: randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Centro Universitário do Maranhão - UNICEUMA	Centro Universitário do Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-10kbw6nx	<NULL>	Ages between 18 and 50 years old; patients of both genders; diagnosed with pulp alteration with indication of radical endodontic treatment in molars; painless; no periapical lesion; with curvature of up to 25º and who sign the informed consent form	Presence of internal or external resorption; trismus; ankylosis; periodontal condition index less than 3; systemic disease; tooth positioning out of normal alignment; history of trauma; pregnancy; lack of patient compliance; and presence of teeth that require endodontic retreatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-86bzhkv	Electrical Nerve Stimulation associated exercises in patients with low back pain	Not yet recruiting	Intervention	2024-04-05	<NULL>	<NULL>	6921	Low-frequency Transcutaneous Electrical Nerve Stimulation associated stabilization exercises in pain in patients with non-specific chronic low back pain: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-86bzhkv	<NULL>	Men and women; between 18 and 60 years of age; body mass index between 18.5 and 30 kg/m2; non-specific low back pain for at least 12 weeks and pain at least 3 on Visual Analog Scale -  VAS; without prior contact with any electrotherapy current; absence of red flags such as - fracture, infection, tumor, inflammatory arthritis, pain with radicular characteristics, spondylolisthesis and spinal canal stenosis; without previous surgeries in the lumbar spine; no chronic use of analgesic opioids; no skin changes or changes in sensitivity at the application site; without pregnancy and pacemaker use	Participants who start using analgesics that modulate the primary outcome during treatment; accidents that prevent the exercise protocol; pregnanc; death and change of residence from the study state	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-5v35crn	Factors associated with self-perception of pain after application of low-power laser in patients using orthodontic appliances: a randomized clinical study	Recruitment completed	Intervention	2024-04-05	<NULL>	<NULL>	6922	Factors associated with self-perception of pain after Photobiomodulation in orthodontic patients: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Faculdade de Odontologia da Universidade Federal do Pará	Faculdade de Odontologia da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-5v35crn	<NULL>	Young and adult patients, between 12 and 50 years old; of both sexes; undergoing orthodontic treatment in the alignment and leveling phase; that present absence of systemic, periodontal or periapical diseases; have good hygiene; not having had previous orthodontic treatment	Intake of analgesics and anti-inflammatories, anticonvulsants, steroids, bisphosphonates during the study; chronic pain; facial neuralgia; psychological disorders; endodontic treatment; gum inflammation; any local or systemic condition that may affect pain perception; pregnancy or breastfeeding; dental or periodontal problems; patients who do not fill out the visual analogue scale correctly or fill it out after the pre-determined time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-27y2rqq	Use of Laser Ablation in the treatment of inicial breast Cancer	Terminated	Intervention	2024-04-04	<NULL>	<NULL>	6917	Use of Ultrasound guided Percutaneous Interstitial Laser Ablation in the treatment of stage I  breast Cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-09-01	Universidade federal de sao paulo	Sociedade Beneficente Israelita Albert Einstein - AmigoH	https://ensaiosclinicos.gov.br/rg/RBR-27y2rqq	<NULL>	Women aged between 18 and 80 years with unifocal stage I breast cancer (less than 2 cm), confirmed by image methods ( mammogram, ultrasound and magnetic resonance), and core biopsy	Patients over 80 years old or with comorbidities that contraindicate the surgical procedure; Multifocal/multicentric tumors detected by any imaging method; Tumors measuring more than 2 cm by any imaging method; Tumors located less than 1 cm from the skin or pectoral muscle; Inability to commute between the treatment centers; Use of anticoagulants or antiplatelet agents up to one week before the procedure (laser or surgery); Psychiatric illness that impairs understanding and adherence to treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-4xc2sk8	Realistic simulation training for pressure injury prevention with nursing professionals	Recruitment completed	Intervention	2024-04-04	<NULL>	<NULL>	6919	Effect of in situ simulation on teaching-learning of nursing professionals for pressure injury prevention: pilot and feasibility study	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-26	Hospital de Clínicas da Universidade Estadual de Campinas- Unicamp	Universidade Estadual de Campinas - Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-4xc2sk8	<NULL>	Female and male nursing professionals over 18 years of age; who provide care to critical patients at risk of developing pressure injuries or with existing injuries; work in the chosen intensive care unit	Professionals who were not present in the unit during the data collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-32z6gw2	Research on pelvic floor health and abdominal muscle separation in pregnant and postpartum women: prevention and treatment	Recruiting	Intervention	2024-04-04	<NULL>	<NULL>	6920	Pelvic floor function and rectus abdominis muscle diastasis in pregnant women and postpartum women - prevention and treatment study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-32z6gw2	<NULL>	Pregnant women - nulliparous and multiparous women at 20 weeks of gestation with a pregnancy of usual risk. Postpartum women (abdominal diastasis, intact perineum, first and second-degree lacerations) - women with abdominal rectus muscle diastasis, who have an intact perineum, cesarean delivery, or first or second-degree lacerations, within one year postpartum. Postpartum women (third and fourth-degree lacerations) - women with or without pelvic floor dysfunction (urinary incontinence, flatus or fecal incontinence, genital prolapse, genital laxity), with third or fourth-degree lacerations, within one year postpartum	Pregnant women - pregnant women with high-risk pregnancies and/or diseases that may interfere with participation. Postpartum women (abdominal diastasis, intact perineum, first and second-degree lacerations) - women who have third and fourth-degree lacerations after vaginal delivery, do not wish to participate in the study, and have serious maternal and infant diseases. Postpartum women (third and fourth-degree lacerations) - women with first or second-degree lacerations after vaginal delivery, do not wish to participate in the study, and have serious maternal and infant diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-96d3pvr	Effects of physical exercise and red grape juice on oxidative stress, inflammation and cardiac autonomic modulation in patients with Cystic Fibrosis	Recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6908	Effects of Physical Training and Red Grape Juice on oxidative stress, inflammation and cardiac autonomic modulation in patients with Cystic Fibrosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-02	Hospital Universitário Lauro Wanderley/HULW, Universidade Federal da Paraíba/UFPB	Hospital Universitário Lauro Wanderley/HULW, Universidade Federal da Paraíba/UFPB	https://ensaiosclinicos.gov.br/rg/RBR-96d3pvr	<NULL>	Diagnosis of Cystic Fibrosis by positive sweat test and/or presence of one or more mutations in the cystic fibrosis transmembrane regulatory gene (CFTR) ; not being indicated for or having undergone lung transplantation; no renal or hepatic dysfunction; be between 5 and 18 years old; do not regularly consume red grape juice, as well as food supplements that contain bioactive substances present in grapes (polyphenols)	Participants who do not perform all procedures; experience gastric discomfort with ingestion of grape juice during the study; present changes in kidney or liver function; have intolerance to physical training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-10xvvn39	Mixture of green banana pulp and peel flour: use in the production of functional foods and effect on the health of overweight people	Not yet recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6909	Mixed prata green banana pulp and peel flour: potential application in the development of functional foods, and impact on intestinal health and metabolic changes in individuals with obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-05-26	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-10xvvn39	<NULL>	women between 20 and 55 years of age; body mass index 27 and &lt;30 kg/m²; high waist circumference (80 cm); excess body fat (&gt; 30% for women) associated with at least one other component of metabolic syndrome: triglycerides 150 mg/dL or blood pressure 30/85 mmHg) or fasting glycemia fasting blood glucose 100 mg/dL/HgA1&gt;57% or HOMA-IR&gt;3.2 (fasting blood glucose/insulin) who is taking medication to control these markers; or obesity (BMI &gt;= 30 kg/m²); high waist circumference ( 80 cm for women) and excess body fat (&gt; 30% for women) regardless of the presence of the other components of the syndrome	women aged &lt; 20 years or &gt; 55 years; BMI&lt;27 kg/m²; absence of at least one other component of metabolic syndrome; waist circumference &lt; 80 cm; body fat percentage &lt; 30%; consumers; pregnant women; lactating or menopausal or climacteric with or without hormone replacement; athletes; vegans; patients with a history of HIV; digestive diseases or changes; hepatic; renal; cardiovascular; thyroid; Cancer; inflammatory diseases and eating disorders; history of drug and/or alcohol abuse; infectious episode in the last month; I have not had COVID in the last 6 months; use of antiinflammatory medications, corticosteroids, antibiotics and others that may affect appetite and energy metabolism; weight instability without weight (5% of usual weight) in the last 3 months; alcohol consumption &gt; 21 units (168g) per week; aversion or intolerance to foods provided in the study; consumption of dietary supplements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-34dc8f4	Effect of physical training associated or not with Whole-Body Electromyostimulation at elderly people survivors of COVID-19	Not yet recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6910	Effect of physical training associated or not with Whole-Body Electromyostimulation in Functional, Vascular and Autonomic variables of elderly people survivors of COVID-19: controlled clinical trial and randomized	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2024-06-17	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-34dc8f4	<NULL>	Elderly people of both sexes; aged over 60 years; positive diagnosis for COVID 19 according to the test at least 2 months before being included in the exercise protocol; classified with Post COVID 19 Functional Status Scale greater than 2; volunteers who tested positive for COVID 19 and were isolated at home; as per WHO guidance; elderly people who required hospitalization due to COVID 19 after 30 days of hospital discharge as previously recommended and who present post COVID 19 syndrome; patients with persistent symptoms of fatigue and dyspnea within 1 to 3 months after confirmed diagnosis of COVID 19	Volunteers with orthopedic or neurological impairments that prevent participation in a physical exercise program; myocardial infarction; within six months of the beginning of the study; implanted pacemaker or any metallic synthesis; history of heart disease; unstable angina; arterial hypertension controlled; uncontrolled or insulin dependent diabetes mellitus and participation in a regular physical exercise program at the beginning of the study; hospital admission less than 72 hours ago; volunteers will also be excluded if they present hypersensitivity to electrical stimulation; chronic obstructive pulmonary disease;heart failure; asthma; previous tuberculosis; bronchitis; lung cancer; a condition that may compromise the performance of functional tests, documented diabetic neuropathy; cognitive deficit; difficulty understanding or adherence to study procedures; declared users of illicit drugs; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-8bsz56g	Health and physical capacity of elderly people treated by the public health system	Recruiting	Observational	2024-04-03	<NULL>	<NULL>	6911	Health conditions, functional capacity and quality of life: subsidies for public policies and practical actions for the health and autonomy of the elderly attended by the basic health units in jataí-go	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Federal de Jataí	Universidade Federal de Jataí	https://ensaiosclinicos.gov.br/rg/RBR-8bsz56g	<NULL>	Elderly individuals of both genders; age equal to or greater than 60 years; undergoing treatment at the basic unit; residents in Jataí-GO	Refusal to participate; presenting physical and intellectual disabilities; having motor limitations preventing tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-4zsh6g8	Prevention of drug-induced Bone Necrosis in the oral cavity in Cancer patients undergoing Tooth Removal – randomized clinical trial	Recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6913	Prevention of drug-induced jaw Osteonecrosis in oncological patients undergoing Exdontics – randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-02	Sociedade Pernambucana de Combate ao Câncer	Universidade de Pernambcuo	https://ensaiosclinicos.gov.br/rg/RBR-4zsh6g8	<NULL>	Patients over 18 years of age; both genders; presence of teeth requiring simple extraction; patient submitted to medications that induce osteonecrosis of the jaw for antineoplastic treatment	Patients who underwent radiotherapy treatment in the head and neck region; patient diagnosed with metastasis in gnathic bones; patients with any known contraindications or allergies to methylene blue or some of the prescribed medications; patients with any clinical impediment to performing photobiomodulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-49gqnnz	Comparison between two materials to stop enamel caries lesions in permanent teeth - randomized clinical trial	Recruitment completed	Intervention	2024-04-03	<NULL>	<NULL>	6914	Comparison between ART and Silver Diamino Fluoride sealants for enamel caries lesions in permanent molars - randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-27	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-49gqnnz	<NULL>	Children whose guardians accept and sign the TCLE (Free and Informed Consent Form); children aged 7 to 13 who allow treatment in schools; both genders; children with erupted first permanent molars or enamel carious lesions (International Caries Detection and Assessment SystemICDAS 1-3)	Children whose parents do not sign the consent form. Children who are absent on the day of treatment. Children who do not cooperate with treatment. Teeth with carious lesions in dentin international Caries Detection and Assessment System ICDAS 4-6. Teeth with enamel defects (amelogenesis imperfecta, hypomineralization molar-incisor, enamel hypoplasia)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-10mc9dwz	Evaluation of the use of Membranes incorporated with Ozonized Oil in the healing of Extraction Surgery of lower third molar teeth: randomized, split-mouth, prospective, double-blind clinical trial	Not yet recruiting	Intervention	2024-04-03	<NULL>	<NULL>	6915	Evaluation of the use of Nanofibers incorporated with Ozonized Oil in the healing of lower third molar extractions: randomized, split-mouth, prospective, double-blind clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-06-15	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10mc9dwz	<NULL>	Adult patients aged 18 to 59 years; of both sexes; without problems systemic; with semi-retained teeth 38 and 48 indicated for extraction	Patients with fully erupted lower third molars; patients with diseases such as hypertension; diabetes and syndromes; pregnant patients; patients with diagnosis of platelet problems; smokers or alcoholics; patients under 18 years of age and over 59 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-2xxcvqj	Mild ovarian stimulation: lowest cost in vitro fertilization protocol to serve couples with difficulty to get pregnant at Hospital das Clínicas da USP	Data analysis completed	Intervention	2024-04-03	<NULL>	<NULL>	6916	Minimal Ovarian Stimulation: Low Cost In Vitro Fertilization Protocol for Infertile Couples at a University Center for Human Reproduction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-26	Hospital das Clínicas da Universidade Federal de São Paulo	Hospital das Clínicas da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2xxcvqj	<NULL>	women aged up to 38 years; body mass index (BMI) up to 30 kg/m²; FSH dosage less than 10 mUI/ml; antral follicle count in the initial follicular phase higher than 5 follicles	sperm collection performed by any method other than masturbation, such as epididymal or testicular puncture; couples who did not agree with the Informed Consent Form (TCLE)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-8g8ckzm	Effect of Magnetic Waves on postoperative pain control of foot and ankle surgery - clinical, controlled, randomized trial	Recruitment completed	Intervention	2024-04-03	<NULL>	<NULL>	8293	Effect of Peripheral Magnetic Stimulation on postoperative pain control of foot and ankle surgery - clinical, controlled, randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-8g8ckzm	<NULL>	Individuals in the immediate postoperative period of foot and ankle surgeries; age greater than or equal to 18 years	Presence of other pain acute or chronic other than post-operative pain; malignant neoplasms; pregnancy; severe circulatory disease; severe neurological disease; severe cardiac disease; severe respiratory disease; severe orthopedic disease; infection; cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:50
RBR-4d7kgrw	An internet-delivered pain and exercise education program for low- and middle-income individuals with back pain	Not yet recruiting	Intervention	2024-04-02	<NULL>	<NULL>	6907	Efficacy and equity of exercise combined with Education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-04	Universidade Federal dos Vales de Jequitinhonha e Mucuri	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4d7kgrw	<NULL>	Patients over the age of 18 who have had nonspecific low back pain for at least 3 months; able to read and understand Portuguese; have access to the internet	Suspected or confirmed severe spinal pathology; fracture; metastatic diseases; inflammatory or infectious diseases of the spine; generalized neurological disorder; previous history of spine surgery in the last 12 months; pregnancy; and contraindications to exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-747k8vb	The effect of Electrical Brain Stimulation in patients with Primary Dysmenorrhea	Recruiting	Intervention	2024-04-02	<NULL>	<NULL>	7988	Transcranial Direct Current Stimulation in women with Primary Dysmenorrhea: usability and clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-15	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-747k8vb	<NULL>	Age between 18 and 45 years; medical diagnosis of primary dysmenorrhea according to Guideline Nº 34539; mean pain equal to or greater than 4 on the Visual Analogue Scale of Pain; periodic pain of at least 3 menstrual cycles in a row; having a regular menstrual cycle of 28 to 32 days; no pelvic inflammatory disease; history of head trauma; epilepsy; endometriosis; current pregnancy; chronic abdominal pain unrelated to the menstrual cycle; fibroids; inflammatory bowel syndrome; irritable bowel syndrome; major abdominal or pelvic surgery; alcohol dependence; nicotine or drugs; metallic implant; pacemaker; and chronic urinary tract disease	Severe headache in more than two transcranial stimulation sessions; dizziness or severe migraine in more than two transcranial stimulation sessions; failure to perform 2 or more transcranial stimulation applications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-8gj3fkt	The effect of Electrical Stimulation on muscles in patients with Chronic Kidney Disease	Data analysis completed	Intervention	2024-04-01	<NULL>	<NULL>	6905	Neuromuscular Electrical Stimulation in patients with Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal do Pará	Fundação Pública Estadual Hospital das Clínicas Gaspar Vianna	https://ensaiosclinicos.gov.br/rg/RBR-8gj3fkt	<NULL>	Volunteers diagnosed with Chronic Kidney Disease (CKD); performing hemodialysis on an outpatient basis; age greater than or equal to 18 years; both sexes; level of functioning with a score greater than or equal to 4 on the Johns Hopkins Highest Level of Mobility Scale (ability to transfer from a bed to an armchair); ability to understand study procedures	Volunteers with a pacemaker or implantable cardioverter-defibrillator; neuromuscular diseases; epilepsy; allergic reactions to electrodes; peripheral edema; ischemia in lower extremities; obesity with a body mass index greater than 35; symptomatic ischemic heart disease; history of myocardial ischemia and angina in the last 6 months; significant valvular heart disease or dysrhythmia; unstable medical condition due to acute or chronic illness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-9x9kcs6	Effects of physical exercise on the health of people deprived of their liberty	Recruitment completed	Intervention	2024-04-01	<NULL>	<NULL>	6906	Functional Training for penitentiaries and its effects on behaviors associated with health and improved mood	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-16	Universidade Federal de Sergipe	Complexo Penitenciário Dr. Manoel Carvalho Neto	https://ensaiosclinicos.gov.br/rg/RBR-9x9kcs6	<NULL>	Inmates appointed by the prison&apos;s management; age between 18 and 50 years old; male; considered to be of low risk; with at least one year&apos;s imprisonment; who showed interest in taking part in the study	Individuals who were being treated for any illness; had committed crimes classified as heinous; had serious indiscipline in their history; who could compromise the organization and development of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-9fmjf77	Longitudinal validation of the DHEQ-15 Brazilian questionnaire	Recruiting	Intervention	2024-03-31	<NULL>	<NULL>	6904	Longitudinal validation of the Brazilian version of the Dentine Hypersensitivity Experience Questionnaire (DHEQ-15)	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-12	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-9fmjf77	<NULL>	Patients complaining of dentin hypersensitivity with cold, sweets, acidic foods and brushing, and with clinical diagnosis of dentin hypersensitivity; both sexes; without distinction of color or socioeconomic condition; age over 18 years; with good general and oral health	Patients presenting restorations and carious lesions in the exposed dentin of hypersensitive teeth; who used painkillers, anti-inflammatories and antidepressants frequently; and presence of gingival inflammation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-379g2cz	Effect of Green Banana Biomass on Overweight men and women’s health	Recruiting	Intervention	2024-03-30	<NULL>	<NULL>	6902	Effect of Green Banana Biomass consumption associated with Energy Restricted Diet on gut and related variables in individuals with Excess Weight and Body Fat	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-16	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-379g2cz	<NULL>	Men and women; between 20 and 40 years old; body mass index between 25 and 34.9 kilograms per meter squared; body fat percentage above 30; food inhibition/disinhibition level less than or equal to 14; weight loss of less than 3 kilograms in the last 12 weeks; level of physical activity stable between irregularly active and active; who consume breakfast regularly	Smokers; pregnant/breastfeeding women; women who have menstrual irregularities in the last three months; elite athletes; consumption of probiotics, prebiotics or synbiotics more than 2 times/week in the month before the start of the study; changes in the level of physical activity and body weight greater than 3 kilos in the last three months; vegetarians; regular consumption of alcohol; use of supplements or medications; presence of allergy or food intolerance or aversion to the tested ingredients; gastrointestinal diseases; chronic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-86t94mn	Clinical evaluation of restorations using an Universal Adhesive and a surface treatment	Recruitment completed	Intervention	2024-03-30	<NULL>	<NULL>	6903	Evaluation of the longevity of direct restorations of non-carious Cervical Lesions using a Universal Adhesive and surface pretreatment. Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-25	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-86t94mn	<NULL>	Volunteers at least 18 years of age; both genders; in good general health; with at least 4 teeth (premolars or molars) with non-carious cervical lesions with a depth and extension of at least 1 mm, vital and without mobility; with at least 20 teeth in occlusion	Volunteers with medical conditions that may interfere with the volunteer&apos;s health, such as allergic reactions to substances or products that will be used; use of a removable prosthesis with a clip on the tooth that will be used in the research; active caries lesions and/or defective restorations in the tooth to be analyzed and/or with periodontal disease; severe bruxism; professional desensitizing treatment in the last 6 months on the tooth that will be used in the research; research participants who are pregnant or breastfeeding; research participants undergoing orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-2dch2qr	Assessment of the absorption and antioxidant effect of vitamin C microparticles in elite football players	Recruitment completed	Intervention	2024-03-28	<NULL>	<NULL>	6900	Ascorbic acid microcapsules: study of absorption and antioxidant activity in vivo	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2011-02-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2dch2qr	<NULL>	Age 18-25 years; male; regular physical training for 7 days a week and 90-120 minutes a day; participation in national or international competitions; absence of chronic non-communicable diseases; lack of consumption of nutritional supplements	Diagnostic of chronic non-transmissible diseases; consumption of nutritional supplements with vitamin C within the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-5y7hmk3	Relationship between the physical, mental and social profile of volleyball athletes with Injury and performance	Recruiting	Observational	2024-03-28	<NULL>	<NULL>	6901	Epidemiological profile of Sports Injuries and performance throughout the macrocycle: relationships with Objective and Subjective Measures of physical, mental and social status of volleyball athletes	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5y7hmk3	<NULL>	Volleyball athletes; federated in Paraná´s youth categories; between 14 and 21 years old	Feeling uncomfortable to answer Questionaries; feeling pain to perform the physical tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-2qp9gtg	Effects of a Treatment using the Pilates Method in patients with Back Pain	Recruiting	Intervention	2024-03-27	<NULL>	<NULL>	6897	Effects of a treatment Protocol using the Pilates Method in patients with Chronic Non-specific Low Back Pain	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-11-21	Fundação Presidente Antonio Carlos	Fundação Presidente Antonio Carlos	https://ensaiosclinicos.gov.br/rg/RBR-2qp9gtg	<NULL>	Individuals of both sexes; aged between 20 and 59 years; with chronic non-specific low back pain, lasting at least 3 months; who are not undergoing physiotherapy or practicing Pilates	Not meeting the inclusion criteria; presence of pain radiating to the lower limbs; fibromyalgia; pregnancy; neurological or cognitive diseases; cardiovascular diseases and morbid obesity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-106nvs7h	Assessment of the healing of venous ulcers of the lower limbs through the use of brazilian mangrove plant extract cream	Recruitment completed	Intervention	2024-03-27	<NULL>	<NULL>	6898	Assessment of the speed of wound healing of venous ulcers through the use of brazilian mangrove plant cream	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2022-08-01	Jéssica Guido de Araújo Sá	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-106nvs7h	<NULL>	Patient aged 18 or over; patients with venous ulcers in the lower limbs.	Patients under 18 years of age; patients who do not sign the Consent Form; patients with ulcers of other etiologies or mixed; patients with factitious dermatitis; or with cognitive deficits or previous psychiatric disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-5jhmkn6	Early mobilization in patients undergoing Bariatric Surgery	Recruiting	Intervention	2024-03-27	<NULL>	<NULL>	6899	Early mobilization in patients undergoing Laparoscopic Bariatric Surgery: interventional clinical study	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal de Alfenas	Hospital e Maternidade Galileo	https://ensaiosclinicos.gov.br/rg/RBR-5jhmkn6	<NULL>	Age greater than 18 years old up to 65 years old; both genders; patients who will undergo bariatric and metabolic surgery via laparoscopy; adequate preoperative pulmonary function test; patients without previous lung disease; patients without radiological changes preoperatively; those who agree to sign the Free and Informed Consent Form	Hemodynamic instability (MAP &lt; 60mmHg) in the postoperative period that prevents early ambulation; conversion from laparoscopy to laparotomy; patients who underwent a surgical procedure other than bariatric and metabolic surgery, such as cholecystectomy, herniorrhaphy, hiatoplasty and liver biopsy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-6hmfkgs	Elastographic analysis of the muscle after the application of thermal therapies.	Not yet recruiting	Intervention	2024-03-26	<NULL>	<NULL>	6895	Elastographic analysis of muscle tissue in healthy subjects after interaction with thermal resources	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-10	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-6hmfkgs	<NULL>	Healthy volunteers; Aged between 18 and 30 years old.	Present neuromuscular injuries involving the knee extensor muscles; Present thermal sensitivity disorders; Have performed exercises with load on the lower limbs in the last 72 hours; Have ingested caffeine and energy drinks 24 hours before the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-8nm6mb7	The impact of surgical guide stabilization on the accuracy of guided surgery in posterior edentulous regions. A randomized clinical trial	Recruiting	Intervention	2024-03-26	<NULL>	<NULL>	6896	The impact of surgical guide fixation on the accuracy of guided surgery in free-ending position. A randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-05	Faculdade de Odontologia da Universidade de São Paulo (FOUSP)	São Leopoldo Mandic - São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8nm6mb7	<NULL>	Consent to take part in the study; kennedy class I or II, with 02 missing teeth in the posterior mandible; adequate systemic condition, with the consent of the medical team; sufficient bone condition for the installation of conventional dental implants	Presence of systemic co-morbidity considered to be a risk factor and/or altering the normal course of treatment; kennedy class III and IV patients; any absence of an anterior dental element; absence of more than two posterior dental elements in the same quadrant; bone defects that require prior reconstruction before the installation of implants; the presence of bone defects that require regenerative or reconstructive approaches simultaneously with implant installation; failure to follow any pre-surgical recommendations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-10cg75rw	Clinical evaluation of in-office Bleaching Agents	Recruitment completed	Intervention	2024-03-25	<NULL>	<NULL>	6891	Evaluation of different In-office Bleaching Agents: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-10cg75rw	<NULL>	Have at least 24 teeth in the mouth. Be interested and available for treatment. Good periodontal health, without the need for interventions. Good general health. Dental elements color A3 or darker according to the Vita Classical shade guide. Caries-free teeth.Teeth without restorative needs	Patients who refuse to participate in the treatment. Pregnant women. Nursing mothers. Smokers. Patients with bruxism or another condition that causes gingival recession and/or dentine exposure. Patients who have already undergone dental bleaching. Patients who report spontaneous sensitivity and/or sensitivity generated by cold drinks and foods. Patients undergoing orthodontic treatment. Patients undergoing periodontal treatment. Patients with ISG &gt;30% of the areas/sites involved. Patients with IPV &gt;30% of the areas/sites involved. Anterior teeth with restoration on the buccal surface. Anterior teeth with veneers or crowns.Teeth with internal staining (tetracycline, fluorosis or endodontic treatment). Endodontically treated anterior teeth.· Patients being treated with anti-inflammatories and/or analgésico	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-2h7szdg	Music Therapy in the treatment of Parkinson&apos;s Disease: a pilot study	Recruitment completed	Intervention	2024-03-25	<NULL>	<NULL>	6892	Effect of Music Therapy on inhibitory control in Parkinson&apos;s Disease: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-20	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2h7szdg	<NULL>	Participants with an established diagnosis of idiopathic Parkinson&apos;s disease, in stages I to 99 on the Hoehn and Yahr scale, with a score greater than or equal to 26 at Montreal Cognitive Assessment- MoCA; both genders	Participants diagnosed with other neurological disorders; visual and/or auditory deficits that compromise understanding and carrying out the activities, and participants who are carrying out monitoring therapeutic for cognitive disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-33dz538	Acute effect of portable device Massage on Muscle Fatigue, Muscle Pain, and Physical Performance in active subjects: a cross-over randomized clinical trial	Recruitment completed	Intervention	2024-03-25	<NULL>	<NULL>	6893	Acute effect of Percussive Massage on Muscle Fatigue, Muscle Pain and Physical Performance in active subjects: a randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-33dz538	<NULL>	Active participants aged 18 to 40; of both sexes; with at least 6 months of experience in leg extension exercises	Participants self-reporting muscular or skeletal pain or injury in the hip and knee at the time of the initial assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-6fzjjqx	Analysis of the occurrence of Urine Flow Obstruction in the recent postoperative period of patients undergoing different types of adjustments in the treatment of Urinary Incontinence. Clinical study with random choice of patients, with researchers and patients who do not know which treatment was applied	Recruiting	Intervention	2024-03-25	<NULL>	<NULL>	6894	Assessing incidence of Infravesical Obstruction in early post-operative of Autologous Fascial Sling between different tensioning technics: a randomized and double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-06	Hospital de Clínicas de Porto Alegre da Universidade Federal do Rio Grande do Sul - HCPA	Hospital de Clínicas de Porto Alegre da Universidade Federal do Rio Grande do Sul - HCPA	https://ensaiosclinicos.gov.br/rg/RBR-6fzjjqx	<NULL>	Patients from the Urology outpatient clinic of the Hospital de Clínicas de Porto Alegre; female; over 18 years of age; with failure of conservative treatment for stress urinary incontinence (behavioral therapy with or without a combination of physiotherapy or medication treatment) and agreeing to the informed consent form	Patients with neurogenic etiology of symptoms; previous bladder surgeries; patients with bladder lithiasis; underactive bladder; previous urinary retention and/or infravesical obstruction; interstitial cystitis; patients with urological cancers or grade &gt; 2 vaginal prolapse; patients with severe cardiopulmonary pathologies; acute symptoms of urinary tract infection or recurrent infections; diabetes mellitus decompensated; pregnant women; patients with postoperative follow-up time less than 12 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-9ppzp9h	The Effect of Health Education in Strengthening the Practice of Breast-feeding	Recruitment completed	Intervention	2024-03-24	<NULL>	<NULL>	6890	Effectiveness of Health Education in Strengthening the Practice of Breastfeeding	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Faculdade de Ciências da Saúde do Trairí	Faculdade de Ciências da Saúde do Trairí	https://ensaiosclinicos.gov.br/rg/RBR-9ppzp9h	<NULL>	Postpartum women aged 18 and over; who underwent vaginal birth in January; February and March 2023 at the Ana Bezerra University Hospital; who had two or more children; and who were breastfeeding	Postpartum women with a history of psychological disorders; mothers with HIV Human Immunodeficiency Virus and HTLV Human T Lymphotropic Virus; and those who required admission to the ICU Intensive Care Unit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-103g8nwg	Effects of a single session of Physical Exercise performed in Immersive Virtual Reality and Exergame in young adults subjected to Unpleasant Stimulus	Not yet recruiting	Intervention	2024-03-22	<NULL>	<NULL>	6886	Comparison of the physiological and psychobiological effects of a single session of Physical Exercise carried out in Immersive Virtual Reality and Exergame in young adults subjected to Unpleasant Stimulus	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-09-02	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-103g8nwg	<NULL>	Do not exercise regularly and do not have significant visual impairment (i.e., everyone with normal or corrected-to-normal visual acuity)	Present contraindication to carrying out physical activity; people on their menstrual period; have a diagnosis of mood or anxiety disorders; be using any type of psychotropic drug; have abusive use or dependence on alcohol or tobacco; report some type of labyrinthopathy (Benign Paroxysmal Positional Vertigo, Ménière&apos;s Disease, Labyrinthitis, etc.); not answering any study question; discontinuity of tests; and not being literate (due to the need to respond to questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-387qd2r	The use of a new treatment for female genital lesions caused by the human papillomavirus in the city of São Carlos	Terminated	Intervention	2024-03-22	<NULL>	<NULL>	6887	The use of ultrasonic scalpel associated with Photodynamic Therapy in the treatment of female genital lesions caused by the Human Papillomavirus in the city of São Carlos	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade de São Paulo	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-387qd2r	<NULL>	Female patients between 18 and 60 years old diagnosed with Condylomata Acuminata	Patients pregnant; lactating; immunologically suppressed; and those undergoing other treatment within less than 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-10bqkrcw	Dental and periodontal manifestations in individuals with occlusal overload	Not yet recruiting	Observational	2024-03-22	<NULL>	<NULL>	6888	Occlusal pathologies in individuals with occlusal overload	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-06-03	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10bqkrcw	<NULL>	Voluntary individuals; toothed; without specific complaints; of both sexes; aged 18 years or older; to read and agree to the Informed Consent Form	Individuals who do not have a compatible smartphone to respond to the required questionnaires; wearers of full or partial removable dentures in one or both arches; with fixed protocol-type prostheses; in orthodontic treatment or still in upper retainer use; with iodine allergy; with active periodontal disease; using an occlusal splint; using a mouthguard; on continuous Selective Serotonin Reuptake Inhibitor (SSRI) medication; with special needs; pregnant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-6ddhwvw	Development and Validation of a Mobile Application for Monitoring Musculoskeletal Pain and Guiding Core Muscle Training in Military Police	Recruitment completed	Intervention	2024-03-22	<NULL>	<NULL>	6889	Development and validation of a mobile application to monitor Musculoskeletal Pain and guide Core Training in military police officers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-05	Universidade Tecnológica Federal do Paraná	Universidade Tecnológica Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6ddhwvw	<NULL>	Being a volunteer; Being an active military police officer; Not taking medication that affects pain levels; Having mild to moderate lower back pain;  Not having any injury or condition that prevents the performance of the proposed exercises in this document.	Not completing the nine weeks of the study;  Failing to respond to sociodemographic and musculoskeletal pain/discomfort questions; Sustaining any type of injury or experiencing pain that prevents participation in the study; Initiating medication treatment for pain mitigation;  Increasing the intensity of pain to a very strong level.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-9t9j3hs	Effects of a Virtual Reality Exercise program on pain in Fibromyalgia patients	Recruitment completed	Intervention	2024-03-21	<NULL>	<NULL>	6879	Virtual Reality in users with Fibromyalgia	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidad San Sebastián	Universidad San Sebastián	https://ensaiosclinicos.gov.br/rg/RBR-9t9j3hs	<NULL>	Males and females; over 18 years of age; with a diagnosis of fibromyalgia issued by a medical professional under the ACR criteria (2016)	Subjects were excluded from the study when they presented pregnancy or lactation; oncologic pain; uncontrolled metabolic disorder; vertigo or similar condition or any cognitive impairment that hinders the understanding of the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-4kqbbnp	Tranexamic Acid evaluation in nasal surgery to remove pituitary tumors: a randomized double-blind study	Recruiting	Intervention	2024-03-21	<NULL>	<NULL>	6880	Evaluation of Tranexamic Acid use in Endoscopic Nasal Surgery for Pituitary Adenoma Resection: a randomized double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-13	Fundação de Beneficência Hospital de Cirurgia	Fundação de Beneficência Hospital de Cirurgia	https://ensaiosclinicos.gov.br/rg/RBR-4kqbbnp	<NULL>	Volunteers over 18 years old; both genders; nuclear magnetic resonance imaging of the skull showing alterations compatible with pituitary adenomas and pathology confirming pituitary adenoma	Volunteers who will not undergo endoscopic endonasal surgery; patients with hematological disorders; patients with a different anatomopathological diagnosis of pituitary adenoma in the postoperative period; patients with recurrent pituitary tumors and who received a blood transfusion during surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-5m6msq7	Intervention with gait training and visual stimulation on pain and foot function in runners with and without Plantar Fasciitis during the COVID-19 pandemic	Recruiting	Intervention	2024-03-21	<NULL>	<NULL>	6881	Effect of gait retraining with visual feedback on the clinical, functional and biomechanical aspects of plantar load and balance in runners with plantar Fasciitis with and without a history of COVID-19	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-29	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	Obras Sociais e Educacionais de Luz (Universidade Santo Amaro)	https://ensaiosclinicos.gov.br/rg/RBR-5m6msq7	<NULL>	Runners aged between 20 and 50 years; of both sexes; running experience of at least two years;  running at least 20 km per week; having experience in long-distance races or competitions; and regular pattern of hindfoot support	History of previous foot surgery; trauma or fractures in the previous six months; and musculoskeletal disorders, such as: neuropathies, obesity, rheumatoid arthritis, tendonitis, bursitis, ankylosing spondylitis, and difference in length of lower limbs greater than 1.5 cm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-3m46ncg	Treatment of Sleep Apnea with Innovative Intraoral Appliance Customized by Digital Flow	Recruiting	Intervention	2024-03-21	<NULL>	<NULL>	6882	Comparison of CPAP and Intraoral Aplliance for the Treatment of Obstrutive Sleep Apnea	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade de Brasília - Faculdade de Ciências da Saúde	Clínica Faber Hospital Odontológico LTDA	https://ensaiosclinicos.gov.br/rg/RBR-3m46ncg	<NULL>	The inclusion criteria in the treatment group are individuals diagnosed with mild apnea (apnea-hipopnea index bigger than five and smaller than fifteen), moderate apnea (apnea-hipopnea index bigger than fifteen and smaller than thirty) and severe apnea (apnea-hipopnea index bigger than thirty and smaller than fifty) by type I polysomnography; individuals who used Continuous Positive Airway Pressure and did not adapt or just want an alternative to this type of treatment; individuals who refused surgical treatment; individuals with age between forty and seventy years of both genres; individuals with at least ten teeth per arch, including crowns on implants or complete dentures over implants	The exclusion criterias of the treatment group are patients who are edentulous or do not have a minimum amount of teeth per arch necessary for the retention and stability of the intraoral appliance during treatment; patients with severe periodontal disease; patients with acute temporomandibular disorder; patients with pathological evidence of airway obstruction; pacientes with Body Mass Index (BMI = weight/height2) greater than thirty five	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-8zwgpyg	clinical Response of Joint Infiltration in Hip Osteoarthritis with Orthobiologics	Recruitment completed	Intervention	2024-03-21	<NULL>	<NULL>	6883	Joint Infiltration in Hip Osteoarthritis with Bone Marrow Aspiration: randomized clinical trial	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2024-02-05	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8zwgpyg	<NULL>	Individuals who have had pain or swelling in the hip (symptoms relevant to hip joint pain) for at least 4 months; Kellgren-Lawrence grade between 1 and 3 on radiographic evaluation; over 18 years old; both genders	Patients who have undergone a corticosteroid hip joint infiltration within 3 months;  or a Hialuronic Acid -HA joint infiltration within 6 months or history of any of the following medical conditions:diabetes, autoimmune disorders, disorders that require immunosuppression, rheumatoid arthritis, infectious arthritis, history of cancer, neurological condition that compromises gait or any other that compromises the level of consciousness, ongoing infectious diseases, kidney and liver diseases and osteonecrosis of the femoral head with collapse secondary to sickle cell anemia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-733y6zq	The effect of high-intensity interval training (HIIT) in Physical Education classes on physical fitness, mental health and cognitive performance of high school students	Recruiting	Intervention	2024-03-21	<NULL>	<NULL>	6884	Effectiveness of high-intensity interval training (HIIT) in exercise classes Physical Education on physical fitness, mental health and cognitive performance of high school students in Rio Grande, RS: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-18	Universidade Federal de Rio Grande - FURG	Faculdade de Medicina (FAMED/FURG)	https://ensaiosclinicos.gov.br/rg/RBR-733y6zq	<NULL>	Students enrolled in the 2nd year of the Federal Institute of Education, Science and Technology of Rio Grande (IFRS) – Rio Grande Campus; Released to normally attend Physical Education classes and able to perform the physical exercises proposed in the intervention without the need for any adaptation; Age between 15 years and 18 years; Do not use medications that may interfere with the variables analyzed (such as insulin and beta-blockers); Not have heart disease or kidney disease, severe asthma and physical or mental disabilities.	Not be between 15 years old and 18 years old; Use medications that may interfere with the variables analyzed (such as insulin and beta-blockers); Have heart disease and kidney disease, severe asthma and physical or mental disabilities; Those students who, for some reason, are no longer able to perform the exercises during the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-10n7gx74	Effects of cannabis components (THC and CBD) on motor and non-motor symptoms of Parkinson&apos;s disease: a placebo-controlled clinical study	Recruitment completed	Intervention	2024-03-21	<NULL>	<NULL>	6885	Effect of THC and CBD cannabinoids combined on motor and non-motor symptoms of Parkinson&apos;s disease: a double-blind, randomized, placebo-controlled clinical trial (cpf study)	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2024-01-05	Universidade Federal da Integração Latino-Americana	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10n7gx74	<NULL>	Previous diagnosis of idiopathic Parkinson disease; Parkinson disease stage 3 or lower according to the Hoen and Yahr scale; age over 50 years; male or female; clinical manifestation of Parkinson Disease; stable treatment for at least 30 days; sign the informed consent form ICF	Medical decision that participation in the study is not best for the patient; presence of any condition that does not allow the protocol to proceed safely; clinically significant renal, hepatic and cardiovascular disorders previously identified or verified in the selection exams; use cannabinoids through any route of administration; diagnosis of alcohol dependence; history or have first-degree relatives with a history of any level of psychosis; have participated in clinical research projects in the two months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-96h77jx	The effect of hearing loop in speech recognition in noise and listening effort in individuals with hearing loss	Recruiting	Intervention	2024-03-20	<NULL>	<NULL>	6873	Efficacy of hearing loop in speech recognition in noise and listening effort in individuals with sensorineural hearing loss: randomized, double-blind clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-01-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-96h77jx	<NULL>	Hearing aid users for at least six months; have sensorineural hearing loss of any degree; be over 18 years old, have your hearing aid working correctly and have a telecoil. Participants must adhere to the Free and Informed Consent Form	Have conductive and or mixed hearing loss; indication of neurological dysfunction in the medical record; not be able to test in noise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-7q9hnmt	Effect of Manual therapy on Pain, Functionality and Health of the feet of recreational runners	Recruiting	Intervention	2024-03-20	<NULL>	<NULL>	6874	Effect of Myofascial Release on Pain, Functionality and Health of the feet of recreational runners	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7q9hnmt	<NULL>	Volunteers with pain in the forefoot, midfoot or rearfoot assessed by the visual analogue scale (VAS) greater than or equal to three; minimum running experience of at least six months; run at least 20 km per week	Volunteers who have contraindications to manual therapy such as tumors, fractures, rheumatoid arthritis, osteoporosis, severe vascular disease and local skin lesions; surgeries in the ankle and foot regions; diagnosis of fibromyalgia; diabetes; neuropathies; ankylosing spondylitis; difference of more than 1 cm in length between the lower limbs; pain assessed by the visual analogue scale (VAS) less than three; volunteers who are carrying out any types of specific treatments for the ankle and foot region, for example, manual therapy, shock waves, acupuncture and foot reflexology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-2f9w4yy	Clinical evaluation of an experimental product based on Essential Oils for brushing Complete Dentures	Recruiting	Intervention	2024-03-20	<NULL>	<NULL>	6876	Evaluation of experimental Dentifrices based on Essential Oils for Complete Dentures cleaning - Randomized, controlled and crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-14	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2f9w4yy	<NULL>	Inclusion criteria will be 25 patients from both sex; Good general health; Previous and regular use of bimaxillary complete denture made of thermopolymerizable acrylic resin for at least one year and in adequate conditions; Upper complete dentures must also present biofilm on the internal surface and quantification will be carried out according to the Additive Index	Cognitive impairment; Motor difficulties; Prostheses with adaptation problems, relining, repairs or fractures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-8n3nxg8	Healthcare for Individuals with Leg Wounds related to circulatory problems: a study testing a treatment with various possibilities	Data analysis completed	Observational	2024-03-20	<NULL>	<NULL>	6877	Health care of people with Venous Ulcer: proposal for evaluation and multidimensional intervention	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8n3nxg8	<NULL>	Age equal to or greater than 18 years; be registered at any Primary Health Care unit covered by the service; present at least one active venous ulcer	Individuals with venous ulcers completely healed before the start of the study; those who did not attend appointments for more than one month; those who died or moved to a region outside the coverage area after the first collection; patients with mixed or non-venous leg lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-2stb2r8	Radiofrequency for treatment of sexual impotence	Recruiting	Intervention	2024-03-19	<NULL>	<NULL>	6867	Radiofrequency for treatment of Erectile Dysfunction: a new technology for the treatment of this condition	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Hospital Universitário Onofre Lopes	International Research Group	https://ensaiosclinicos.gov.br/rg/RBR-2stb2r8	<NULL>	Men with a diagnosis of vascular erectile dysfunction; with an active sexual partner; score on the IIEF questionnaire (International Index Erectile Dysfunction) - Domain of erectile function equal to or below 25 points	"Men subjected to radical prostatectomy or pelvic cancer surgeries; Pelvic trauma; Psychosomatic cause;Psychiatric treatment
Patients in cancer treatment by chemotherapy or hormone therapy; Patients with symptoms of low libido associated; testosterone levels below 300 ng/dl"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-5zx8rvc	Effect of using a mobile application on the knowledge and self-care of people with heart failure	Recruitment completed	Intervention	2024-03-19	<NULL>	<NULL>	6868	Effect of a mobile application on the knowledge and self-care of people with heart failure: a quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5zx8rvc	<NULL>	Eligible individuals were those who met the following criteria: patients diagnosed with Heart Failure, aged 18 years or older; in follow-up, with a smartphone with Android operating system; taking medication; who had adequate health literacy, according to the Eighth-item Health Literacy Scale (19 points); and oriented in time and space. In order to evaluate the orientation of individuals, the following questions were asked: What is your name? How old are you? What day, month, year and location are we in? What city do you live in?	individuals who, due to clinical decompensation, resulted in previous hospitalization in the last 30 days; who were listed on the heart transplant queue and individuals planning myocardial revascularization or interventional procedure such as Transcatheter aortic valve implantation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-87dk5nk	Online refraction exam	Not yet recruiting	Observational	2024-03-19	<NULL>	<NULL>	6869	Online Refraction Test vs. manifest subjective refraction: Non-Inferiority Clinical Trial	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-03-25	Eyecare Health	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-87dk5nk	<NULL>	Healthy volunteers. Aged between 18 and 40 years. With no history of ocular diseases or current evidence of serious ocular conditions	Participants with refractive error greater than 6 diopters (myopia or hypermetropia), astigmatism greater than 3.00 diopters, antimetropic anisometropia. Diabetes. Pregnancy. Lactation. History of previous ophthalmic surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-6v29sm4	Chinese auriculoacupuncture to reduce pain and impact on daily activities in elderly women treated in a specialized elderly health unit: randomized clinical trial	Recruiting	Intervention	2024-03-19	<NULL>	<NULL>	6870	Chinese auriculoacupuncture for reducing chronic pain and impact on functional capacity in elderly women treated at the elderly health reference unit (URSI): randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal de São Paulo	Unidade de Referência à Saúde do Idoso	https://ensaiosclinicos.gov.br/rg/RBR-6v29sm4	<NULL>	age from 60 years; presence of chronic osteoarticular pain for 3 months or more, and availability of time for auriculoacupuncture sessions.	presence of infection, inflammation or injury in the ear; allergy to microporous tape; carrying out prior energy therapy up to 3 months prior to the intervention; refusal to receive ear treatment. In addition, the criteria for discontinuing the intervention will be adopted: hospitalization, loss of two consecutive sessions and absence of attendance on the days scheduled for the evaluations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-7cfmsdb	The effectiveness of Meditation in enhancing mental health and sleep quality following Liver Transplantation	Recruiting	Intervention	2024-03-19	<NULL>	<NULL>	6871	The impact of Meditation on the mental health and sleep quality of Liver Transplant patients: A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Faculdade Ciências Médicas de Minas Gerais (FCMMG)	Faculdade Ciências Médicas de Minas Gerais (FCMMG)	https://ensaiosclinicos.gov.br/rg/RBR-7cfmsdb	<NULL>	Liver transplant recipients; aged between 18 and 65 years; who have been transplanted for at least 6 months	Volunteers with an indication for retransplantation; hospitalized at the moment; severe physical or mental illnesses in the last 3 months; participants who have practiced meditation in the last 3 months, with a minimum frequency of twice a week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-5h33pjp	Association between brain and heart pressure	Recruiting	Observational	2024-03-19	<NULL>	<NULL>	6872	Association between Intracranial Pressure Compliance and parameters of central and peripheral arterial pressure and hemodynamics	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-11	Faculdade de Medicina da Universidade Federal de Goiás	Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5h33pjp	<NULL>	Subjects will be over 18 years of age; pre-hypertensive (arterial pressure sistolic between 130 and 139 mmHg and/or arterial pressure diastolic between 85 and 89 mmHg) or hypertensive (arterial pressure sistolic higher than 140 mmHg and/or arterial pressure diastolic lower than 90 mmHg) according to office blood pressure measurement	Patients taking blood pressure medication; with stage 3 hypertension (arterial pressure sistolic higher than 180 mmHg and/or arterial pressure diastolic higher than 110 mmHg); pregnant or puerperal women; patients diagnosed with intracranial hypertension; patients with hydrocephalus, previous cardiovascular disease which will be defined as: history of coronary heart disease (angina, previous heart attact), diagnosis of Heart Failure, history of valvular heart disease, diagnosis of cardiac arrhythmias, obstructive peripheral arterial disease, aortic aneurysm, previous stroke and advanced chronic liver disease (Child B and C)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-9bjhhyt	Effectiveness of different techniques for bonding parts of orthodontic appliances	Recruitment completed	Intervention	2024-03-18	<NULL>	<NULL>	6858	Comparison of the effectiveness between Direct and Virtual Indirect Bonding of brackets in orthodontic alignment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Anhanguera educacional participaçoes S/A	UNIC - Universidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-9bjhhyt	<NULL>	Ages between 12 and 35 years old; of both sexes; complete permanent dentures; need of orthodontic treatment; mild to moderate crowding; Class I or Class II Angle malocclusions; good oral hygiene; good periodontal condition.	Patients who require surgical treatment to correct a skeletal discrepancy; have already undergone prior orthodontic treatment; agenesis; hypodontia; hyperdontia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-3q85m7g	Assessment of the level of stress and anxiety in assisted reproduction using Reiki	Recruitment completed	Intervention	2024-03-18	<NULL>	<NULL>	6859	Assessment of the level of stress and anxiety with the application of Reiki in the treatment of assisted reproduction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3q85m7g	<NULL>	Age between 18 and 42 years;  undergoing infertility treatment at the marital infertility outpatient clinic of HCFMRP-USP; participated in the complete basal cycle; regardless of race; religion; creed; socioeconomic status; schooling; parity; Body Mass Index	Women who withdrew from participating in the research; expressed rejection of the proposed objectives; women who have modified the therapeutic path proposed by the method	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-8n3mkym	The effect of Daily Stress on Ocular Pressure in Glaucoma patients	Recruitment completed	Intervention	2024-03-18	<NULL>	<NULL>	6861	Can Psychological Stress increase Intraocular Pressure in Glaucoma patients?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-10	Hospital Oftalmológico de Brasília	Aché Laboratórios Farmacêuticos	https://ensaiosclinicos.gov.br/rg/RBR-8n3mkym	<NULL>	Subjects older than 50 years of age. Primary open-angle glaucoma in early or moderate stage. Submitted to selective laser trabeculoplasthy in both eyes or in use of topical prostaglandin analogue (PGA) therapy in both eyes	Presence of any other ocular disease (with the exception of primary open-angle glaucoma and refractive errors). Anxiety or depressive disorders. Use of medication for anxiety or depressive disorders. History of ocular trauma or surgery. Use of anti-glaucoma drugs. Use of any kind of oral/topical steroids. Cushing syndrome. Congenital adrenal hyperplasia. Adrenal insufficiency	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-9tfcwh4	Impact of physical exercise on the Heart Rate of patients after cardiac surgery	Not yet recruiting	Intervention	2024-03-18	<NULL>	<NULL>	6863	Impact of combined physical exercise on Heart Rate Variability of patients after Cardiac Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Maranhão	Hospital Dr. Carlos Macieira	https://ensaiosclinicos.gov.br/rg/RBR-9tfcwh4	<NULL>	adult patients; in the postoperative period of cardiac surgery; over 18 years of age and under 70 years of age; both sexes; who are on the first postoperative day; who have the cognitive capacity to understand the research process, by signing the Free and Informed Consent Form	have diseases or some type of musculoskeletal disability; bone or joint disorders that make assessments and exercise protocol impossible; mechanical ventilation; neurological and behavioral changes; patients with hematocrit lower than 30%; hemoglobin less than 7; severe lung conditions; pathologies that incapacitate the study, such as amputation of the upper limbs or lower limbs; amaurosis; deep vein thrombosis; patients who were already performing aerobic or resistance exercise;  participants who have unstable angina; decompensated cardiac arrhythmia; interaction difficulties that are unable to answer the questionnaires; systolic blood pressure greater than or equal to 160 mmHg; diastolic blood pressure greater than or equal to 100 mmHg recurrent in 3 sessions; mediastinitis; decompensated diabetes mellitus; fasting blood glucose greater than 300; acute systemic infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-4ng46xj	Dental Sensitivity to in-office bleaching after use of a new Ibuprofen Nanogel	Recruiting	Intervention	2024-03-18	<NULL>	<NULL>	6865	Sensitivity to in-office bleaching by application of a new Ibuprofen Nanogel	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4ng46xj	<NULL>	Be between 18 and 50 years old. Good general and oral health. Have at least 6 anterior teeth in the maxilla free of cavities and restorations and with color A2 or darker on the canine according to the VITA color scale classic never bleached before	"Prosthesis users. Orthodontic appliance users. Patients with severe staining caused by tetracycline, fluorosis,
trauma or teeth with pulp necrosis. Pregnant or breastfeeding women. Patients with bruxism, gingival recession, visible dentin exposure and cracks extensive. Patients with previous or current systemic health problems (stomach, heart, kidneys and liver), continuous users of anti-inflammatories and/or analgesics. Allergic to Ibuprofen or other components of the nanogel"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-23h6k87	Effectiveness of a Mindful Eating for Health Program among Hospital Staff	Recruiting	Intervention	2024-03-18	<NULL>	<NULL>	6866	Effectiveness of a Mindful Eating for Health Program among Hospital Staff: a pragmatic mixed-methods randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23h6k87	<NULL>	Adults; aged 20 to 59; both genders; body mass index equal to or greater than 18.5 kg/m² and less than 40 kg/m²	Individuals undergoing pharmacological treatment for obesity; pregnancy; individuals with untreated hypothyroidism or hyperthyroidism (TSH &lt;0.2 or &gt; 5.5 mlU/mL) or treated less than 6 months ago; individuals in an acute phase of depression (less than 6 months in depression), those with schizophrenia or psychotic disorders, or those using medication that causes cognitive, attention, and concentration impairments (such as potent anxiolytics); practitioners of mindfulness, meditation, yoga, or similar practices within the last 6 months (with formal practice at least once a week); individuals who have undergone any type of bariatric surgery; extreme obesity (BMI equal to or greater than 40 kg/m²); participation in other clinical intervention studies; chronic kidney disease, heart failure, and other clinical conditions that may interfere with fluid balance; individuals who received nutritional guidance in the last 6 months; individuals being diagnosed with anorexia nervosa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-3fzgrq2	Evaluation of an educational program for Primary Health Care users with Type 2 Diabetes Mellitus	Recruiting	Intervention	2024-03-18	<NULL>	<NULL>	7140	Evaluation of an educational program for Primary Health Care users with Type 2 Diabetes Mellitus: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-10	Faculdade de Minas Muriaé	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-3fzgrq2	<NULL>	Individuals aged 20 years or over; of both sexes; covered by the Basic Health Units involved in the study; with a clinical diagnosis of Type 2 Diabetes Mellitus through medical records and/or confirmation from the Family Health Strategy team; able to talk; who have a cell phone with access to a private WhatsApp account or can use a third party&apos;s account on the same application	Individuals who have some cognitive impairment that influences their responses and participation in the study, and such impairment will be considered through the individual&apos;s self-report, when possible, and/or the report of a family member or guardian and/or medical records; individuals who are not available to be present in the intervention groups; pregnant women; nursing mothers; individuals who are undergoing nutritional monitoring in public or private services at the time of the study or have undergone nutritional monitoring in public or private services in the 12 months prior to the study, considering the individual&apos;s self-report and/or records of care in public services	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-5vwfqyx	Analgesic effect and muscle activity of Electrical Cortical Stimulation assited by Peripheral Electrical Stimulation in healthy volunteers	Recruitment completed	Intervention	2024-03-18	<NULL>	<NULL>	7185	Effects of Electrical Cortical Stimulation assisted by Peripheral Electrical Stimulation (priming) on ​​activation of descending pain inhibitory pathway and electrical muscle activity in healthy volunteers	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2023-11-27	Universidade Federal do Delta do Parnaiba-UFDPar	Universidade Federal do Delta do Parnaiba-UFDPar	https://ensaiosclinicos.gov.br/rg/RBR-5vwfqyx	<NULL>	Individuals of both sexes; aged 18 to 35 years; with no history of illnesses or previous surgeries and no complaints of pain (musculoskeletal or visceral)	Chronic pain; concomitant medication that may affect cognitive performance; pregnancy or possible history of pregnancy; drug or alcohol abuse or dependence; recent head injury (within the last 3 months); history of seizure or stroke; neurological; psychiatric diseases and rheumatologic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-62kckb2	Study of Micrografting with a device for bone augmentation	Data analysis completed	Intervention	2024-03-15	<NULL>	<NULL>	6856	Use of bone and periosteal micrograft, associated to the xenograft, in vertical bone reconstruction with Barbell Technique	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-07	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	https://ensaiosclinicos.gov.br/rg/RBR-62kckb2	<NULL>	Patients of both genders; partially edentulous for more than 1 year; with absence of two teeth at least and at most five at the posterior maxilla (unilateral or bilateral); requiring implants in the posterior maxillary region with no more than 4 mm of remaining alveolar ridge; with need for maxillary sinus floor augmentation combined with onlay vertical bone augmentation in one or both sides; all patients should have between 18 and 65 years of age, with adequate oral health	Patients with a history of neoplastic disease treated with radiotherapy or chemotherapy; pregnant or breastfeeding; receiving treatment or affected by an illness that could influence on bone homeostasis; sinus pathologies; smokers; alcoholics; drug addicts	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-3tvtfzq	Cardiopulmonary Resuscitation Learning Program for school-age children	Not yet recruiting	Intervention	2024-03-15	<NULL>	<NULL>	6857	The social impact of the Cardiopulmonary Resuscitation Learning Program for school-age children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-08-01	Centro Universitário Faculdade de Medicina ABC	Centro Universitário Faculdade de Medicina ABC	https://ensaiosclinicos.gov.br/rg/RBR-3tvtfzq	<NULL>	500 children and their respective teachers will be invited to participate in the research. All students from the second to fifth year of Elementary School I and the sixth and seventh year of Elementary II regularly enrolled in educational institutions participating in the research will be included	All students who do not sign the Informed Assent Form (TALE - Annex A) and parental consent form (Annex B), in addition to the authorization signed by the parents (Annex C) will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-7sjynm5	The effect of Intensive Neuromotor Therapies for postural control in children with Cerebral Palsy	Recruiting	Intervention	2024-03-14	<NULL>	<NULL>	6853	Effectiveness of Intensive Neuromotor Therapies for postural control of children with Chronic Non Progressive Encephalopathy of Childhood	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-20	UNISSUAM	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-7sjynm5	<NULL>	Children diagnosed with Cerebral Palsy; Age range from 3 to 8 years; Both sexes; Gross Motor Function Classification System from 1 to 5	Subjects who are not interested in participating in the research; Children who have contraindications to carrying out the protocols intensive using the suit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-10279hdr	"Effect of a technology on obstetric nurses&apos; knowledge about Stress prevention after trauma in pregnancy, labor and puerperium of women with physical disabilities: clinical trial
​"	Recruiting	Intervention	2024-03-14	<NULL>	<NULL>	6854	Effect of educational technology on obstetric nurses&apos; knowledge about post-traumatic Stress prevention in postpartum women with physical disabilities: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-26	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10279hdr	<NULL>	Specialist degree in Obstetrics, Women&apos;s Health or related; aged 18 or over; both genders; six months of experience in obstetrics; employed at the public maternity hospital selected for the study	In the process of retirement; on leave; termination of contract with the service; in administrative areas of the maternity; have more than one employment relationship between the public maternity hospitals participating in the study from the same government sphere	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-103pw9q3	The use of Fat Components to improve Bone Grafting in patients with Tertiary Alveolar Cleft: a prospective, randomized and controlled study	Recruiting	Intervention	2024-03-14	<NULL>	<NULL>	6855	Non-enzymatic Stromal Vascular Fraction used to enhance Bone Grafting in Tertiary Alveolar Cleft patients: a prospective, randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-23	Hospital da Clinicas da Faculdade de Medicina da Universidade de São Paulo	Hospital da Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-103pw9q3	<NULL>	Alveolar cleft; Permanent dentition; No other comorbidities	Bilateral alveolar cleft Primary or secondary alveolar bone graft; Orthodontic treatment less than 2 months before the surgery; Orthodontic movement before 6 months postoperatively; Bad oral hygiene; Other comorbidities and syndromic patients; Disagreement with methodology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-82rpdv9	Effects of food supplementation with vegetable oils containing Medium Chain Triglycerides on the nutritional status and development of inflammation in patients with elephantiasis	Data analysis completed	Intervention	2024-03-13	<NULL>	<NULL>	6852	Effects of dietary supplementation with different levels of Medium-chain Triglycerides on the nutritional status and inflammatory response of patients with Lymphatic Filariasis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Federal de Pernambuco	Instituto Aggeu Magalhães - Fiocruz Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-82rpdv9	<NULL>	Patients registered at the National Reference Service for Filariasis (Fiocruz-PE); residents in an endemic area for lymphatic filariasis; of both genders; aged between 18 and 85 years old, who had lymphedema of the lower limbs	Patients with edema or lymphedema due to liver diseases, neoplasms, congenital lymphatic alterations, cardiac and/or vascular insufficiencies, who, after medical screening, have no indication for follow-up at the Serviço de Referência Nacional em Filarioses (Fiocruz Pernambuco); patients who were already undergoing nutritional monitoring outside Fiocruz Pernambuco, or who had neurological and/or psychiatric diseases that could make it difficult to understand dietary guidelines; pregnant and/or lactating patients; patients who reported rejections, intolerances or allergies to the use of medium chain triglyceride oil as well as coconut oil	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-2gf7h77	Efficacy of multimodal training with several types of exercises to increase walking ability and improve heart function in people affected by stroke	Recruiting	Intervention	2024-03-13	<NULL>	<NULL>	7530	Efficacy of Moderate to High-Intensity Multimodal Circuit Training to increase step count and improve cardiovascular function in individuals Post-Stroke: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-11	Universidade Federal de São Carlos	Irmandade Santa Casa de Misericórdia de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-2gf7h77	<NULL>	Written informed consent was assigned; able to walk even with supervision or assistive walking devices; both women and men; age: 40 - 80 years old; diagnosis of unilateral stroke (≥ 6 months ≤ 5 years); medical allowance to perform moderate to vigorous exercise; memory and cognition preserved (considering the Mini-Mental State Examination scored by age and scholar level); be physically inactive (&lt; 7.500 steps per day); at least 2 doses of COVID-19 vaccines Do not attend to another rehabilitation program; no health issues that can cause symptoms and risks for the patients during the evaluations/training protocol (&lt; 1-month acute myocardial infarct/cardiac; surgery or  pulmonary obstructive/restrictive diseases); no other neurological diseases than stroke; no orthopedic disease that impossibility to walk	Withdraw the consent; present any severe symptoms during the assessments or intervention, such as prior cardiac surgery and/or acute myocardial infarction within one month; pacemaker utilization, obstructive or restrictive pulmonary diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-9hvj4tb	Effects of vocal technique with Acapella on Singers	Recruiting	Intervention	2024-03-12	<NULL>	<NULL>	6848	Immediate effects of Sounded High Frequency Oral Oscillation Technique in singers	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9hvj4tb	<NULL>	being a popular singer of popular genres; like pop; stone; hip hop; R&amp;B; country; MPB;countryside; Gospel; from the city of Itabirito; be active in singing for at least 3 years; be between 18 and 50 years old	being an opera singer; be in speech therapy; have an infection or allergy that affects the upper airways on the day of collection; not being able to perform the technique; self-declare a disease of cardiovascular origin; neurological; pulmonary; cleft lips and/or palate; facial or rib fractures; be a smoker or have a diagnosis of laryngeal disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-85nxvjd	Vacuum Excision: percutaneous minimaly invasive diagnosis and tretament of Early Breast Cancer at once	Recruiting	Intervention	2024-03-12	<NULL>	<NULL>	6849	Vacuum Assisted Excision (VAE): A single-step approach to the diagnosis and percutaneous treatment of Early Breast Cancer	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-29	Faculdades Integradas Pitágoras de Montes Claros	Faculdades Integradas Pitágoras de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-85nxvjd	<NULL>	Women with breast suspicious unifocal lesions BIRDAS-ACR 4 or 5; smaller than 1.5 cm identified by screening or clinical alteration; literate and over 18 years old	Multifocal and multicentric lesions; lesions associated with diffuse and extensive microcalcifications; patients with blood dyscrasias or in regular use of anticoagulant drugs; and non-agreement to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-10rmznpy	Determination of the progression of Erosive Tooth Wear by two Clinical Methods	Not yet recruiting	Observational	2024-03-12	<NULL>	<NULL>	6850	Validation of two methods of Detection and Clinical Measurement of Erosive Tooth Wear: A prospective Cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-04-01	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	Faculdade de Odontologia da Universidade de São Paulo - FOUSP	https://ensaiosclinicos.gov.br/rg/RBR-10rmznpy	<NULL>	To be at least 18 years old; have good oral health; present at least one of the conditions: with diagnosis of gastroesophageal reflux disease, receiving medical treatment or taking over the counter medication for gastroesophageal reflux disease, having heartburn episodes, sour taste in the mouth at least twice a week; having recurrent vomiting; daily consumption of acidic foods and drinks	Active caries lesions or defective restorations; pregnant or breast feeding; subjects with denture; subjects under orthodontic treatment; being in another research in the same period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-9v9gx9s	Effect of using Toothpastes with Desensitizers on reducing Tooth Sensitivity and Quality of Life in adults with previous sensitivity after dental bleaching	Data analysis completed	Intervention	2024-03-12	<NULL>	<NULL>	6851	Effect of using Toothpastes with Desensitizers on reducing Tooth Sensitivity and Quality of Life in adults with previous sensitivity after in-office dental bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2015-08-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9v9gx9s	<NULL>	Individuals dissatisfied with the color of their teeth and with good oral health;  anterosuperior teeth with vitality, free of cavities and restorations on the vestibular surface; upper central incisors with coloration equal to or darker than A2, according to the Vita Classical color scale; stimulated or provoked dentin sensitivity in any superior superior premolar, canine and incisive	Severe intrinsic stains on the teeth (such as tetracycline or fluorosis); active periodontal disease;  use of any anti-inflammatory, analgesic and antioxidant action drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-5jmx32v	Assessment of the Strict Oral Hygiene Phase in the periodontal condition of obese and eutotrophic individuals diagnosed with Periodontitis	Recruiting	Intervention	2024-03-11	<NULL>	<NULL>	6842	Effect of Strict Hygienic Phase prior to Periodontal Therapy on the periodontal and general condition of Obese and Eutrophic patients with Periodontits: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-5jmx32v	<NULL>	Individuals diagnosed with stage III or IV periodontitis, either eutrophic or with obesity grade I according to the World Health Organization (WHO) criteria; both genders; aged between 30 and 60 years; presence of at least 10 teeth in the oral cavity. These participants should not have a history of systemic disease (HIV, hepatitis), be pregnant or lactating, or have undergone antibiotic therapy in the last three months, periodontal treatment in the last six months, orthodontic appliance use, or be undergoing nutritional therapy	Those affected by Covid-19 during the study period will be excluded; participants who do not complete all data collection assessments; initiate nutritional treatment; who do not follow oral hygiene guidelines during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-3cdtw97	Modified Laser Intravascular Blood Irradiation in women with Breast Cancer: clinical trial	Not yet recruiting	Intervention	2024-03-11	<NULL>	<NULL>	6843	Effects of Modified Laser Intravascular Blood Irradiation in women with Breast Cancer: randomized placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Paraná	Liga Paranaense de Combate ao Câncer	https://ensaiosclinicos.gov.br/rg/RBR-3cdtw97	<NULL>	Women over the age of 21; with a clinical diagnosis of unilateral or bilateral primary breast cancer; undergoing conventional adjuvant antineoplastic treatment (chemotherapy, radiotherapy or hormonal therapy); whether or not undergoing surgical treatment to remove the solid tumor; with a score between 0 to 2 on ECGO-OS (Eastern Cooperative Oncology Group Performance Status); with the ability to communicate in Portuguese; residing in Curitiba or the Metropolitan Region; available to participate in research interventions in a 10-week follow-up schedule	Women under 21; who do not agree to participate in this study; illiterate or who present cognitive deficit determined by the MMSE questionnaire - Mini Mental State Examination; hearing deficit that prevents understanding verbal instructions; with the presence or suspicion of metastatic areas, presence of allergies or skin diseases (atopic dermatitis, contact dermatitis, psoriasis or rosacea); pregnant or lactating women; women with a body mass index (BMI) above 40 (due to the presence of comorbidities related to obesity that may interfere with the results); contraindications for the application of mILIB will (cardiogenic shock, arterial hypotension, heart disease, circulatory failure in stages II and III, anemia, sick sinus syndrome, existence of blood coagulopathies, personal history of cancer at the application site); hemorrhagic, infected or photosensitive area; women with phototype VI on the Fitzpatrick scale confirmed by the analyzer as phototype V; blood tumors; pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-6c4cwn5	Skin and vaginal acceptability assessment	Recruiting	Intervention	2024-03-11	<NULL>	<NULL>	6844	Assessment of dermal, gynecological and pH maintenance acceptability	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-11	helianto farmacêutica limitada	medcin instituto da pele limitada	https://ensaiosclinicos.gov.br/rg/RBR-6c4cwn5	<NULL>	Female participants aged 18 to 60; Intact skin in the region of product analysis (vaginal mucosa); Be a user of products in the same category; Agreement to follow the trial procedures and attend the Clinical Research Center on the designated days and times for applications and/or evaluations; Understanding, consent and signature of the Free and Informed Consent Form (TCLE)	Pregnancy or risk of pregnancy and/or lactation;Use of antiinflammatory/ immunosuppressive/ antihistamine drugs up to 3 weeks before selection;Skin marks in the experimental area that interfere with the assessment of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevus, sunburn); Atopic or allergic history to products in the same category; Active skin pathologies and/or lesions (local and/or disseminated) in the assessment area; Immunosuppression by drugs or active diseases; Decompensated endocrinopathies; Relevant medical history or current evidence of alcohol or other drug abuse; Known history or suspected intolerance to products in the same category; Intense sun exposure up to 15 days before the assessment; Aesthetic or dermatological treatment in the evaluation area up to 4 weeks before selection; Employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; Other conditions considered by the researcher to be reasonable for disqualification from participation in the study. If yes, it should be described in observation in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-6whk9jy	Biomechanical aspects of orthodontic treatment with Aligners: a randomized clinical trial	Recruiting	Intervention	2024-03-11	<NULL>	<NULL>	6845	Biomechanical aspects of orthodontic treatment with In-house Aligners: a randomized clinical trial	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Pontifícia Universidade Católica de Minas Gerais	Pontifícia Universidade Católica de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6whk9jy	<NULL>	Volunteers who have or have not received previous preventive orthodontic treatment carried out at PUC Minas and need for the corrective orthodontic phase to complete the case; need for corrective orthodontic treatment with mild to moderate discrepancies; permanent denture completely erupted, with the permanent second molars being in the mouth or not; absence of systemic diseases or regular use of medications that could interfere with normal growth and/or orthodontic movement	Patients who do not have permanent dentures; those with severe malocclusion and systemic diseases that may influence orthodontic treatment will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-7gj8dcw	Evaluation of the gynecological and dermatological acceptability of an intimate moisturizing gloss using the product at home	Recruitment completed	Intervention	2024-03-11	<NULL>	<NULL>	6847	Evaluation of the gynecological and dermatological acceptability of a moisturizing health gloss product under normal conditions of use_Dic02.2023	<NULL>	n/a, n/a, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-14	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	SNF cosméticos LTDA	https://ensaiosclinicos.gov.br/rg/RBR-7gj8dcw	<NULL>	Women; age: 18 to 59 years; phototype: I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; Atopy history; Use of vaginal cream; Participants with a history of allergy to products in the tested category; Recent gynecological surgeries; discharges; Immunodeficiency carriers; Kidney, heart or liver transplants; Active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.; Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-23zdtmv	Influence of functional demands on the relationship between the ability to stabilize the trunk and in specific movements performance	Recruiting	Observational	2024-03-08	<NULL>	<NULL>	6841	Influence of functional demand on the relationships between lumbopelvic stabilization capacity and clinical outcomes of objective function: main study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-30	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-23zdtmv	<NULL>	Volunteers of both genders; aged between 18 and 30 years old	Volunteers with neurological disorders; cognitive impairments; cardiorespiratory diseases; history of joint and muscle injury in the last 2 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-3bqywp7	Use of Simvastatin Gel for the treatment of Peri-implantitis	Recruitment completed	Intervention	2024-03-07	<NULL>	<NULL>	6838	Clinical and radiographic evaluation of the efficacy of Simvastatin in Regenerative Therapy for Peri-implantitis: a controlled and randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-09-21	Universidade Estadual Paulista, Faculdade de Odontologia de Araraquara, FOAR-UNESP	Universidade Estadual Paulista, Faculdade de Odontologia de Araraquara, FOAR-UNESP	https://ensaiosclinicos.gov.br/rg/RBR-3bqywp7	<NULL>	Greater than or equal to eighteen years of age; greater than or equal to three radiographic bone loss ; greater than or equal to six millimeters of probing pocket depth with bleeding on probing; less than or equal to twenty percent of plaque index; less than or equal to twenty percent of gingival index ; formal consent to participate in the research	Presence of uncontrolled systemic alteration; use of medications six months prior to the study that may influence the response to treatment; pregnant and lactating women, performing peri-implant treatment including subgingival instrumentation in the six weeks prior to the study; implants with mobility; oral pathology; history of allergy to any component of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-6srwt2n	The effects of using a probiotic compared to a prebiotic on the symptoms in people with Irritable Bowel Syndrome	Recruiting	Intervention	2024-03-07	<NULL>	<NULL>	6839	Comparison of the effects of a probiotic and a prebiotic on Irritable Bowel Syndrome	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-10	Hospital de Clínicas da Universidade Federal do Paraná	RiteCarbs LLC	https://ensaiosclinicos.gov.br/rg/RBR-6srwt2n	<NULL>	age older than 18 years; eutrophic or overweight with body mass index between 18.5 and 29.9 kg/m²; with I rritable Bowel Syndrome C symptoms according to Rome IV criteria; with complete primary education	other gastrointestinal diseases; kidney disease; liver diseases; gastrointestinal tract surgery; allergies to gluten and lactose;  have used antibiotics or prebiotics or probiotics or symbiotics in the last 4 weeks; scleroderma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-53xtrxx	Vocal behavior and facial of elderly people with Parkinson under the effect of Stimulation Transcranial Direct Current and Photobiomodulation	Not yet recruiting	Intervention	2024-03-07	<NULL>	<NULL>	6840	Randomized clinical trial of vocal behavior and facial of elderly people with Parkinson under the effect of Stimulation Transcranial Direct Current and Photobiomodulation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-10	Universidade Federal da Paraíba - UFPB	Universidade Federal da Paraíba - UFPB	https://ensaiosclinicos.gov.br/rg/RBR-53xtrxx	<NULL>	Age group with a minimum age of 65 years; both sexes; diagnosis of Parkinson&apos;s disease at stage 1, 2 or 3 of the Hoehn and Yahr Scale Scale; and without previous speech-language pathology treatment of the voice in the last year with technological resources of Photobiomodulation and Stimulation Transcranial Direct Current (tDCS)	Other associated vocal alterations (detected by previous otorhinolaryngological evaluation); hearing loss; previous acquired brain injuries; general health, cognitive and/or psychiatric conditions that limit the comprehension or performance of the tasks to be performed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-6jm5zht	Effect of a vein illuminator device on the success of peripheral venipuncture in adults with difficult access: randomized controlled trial	Recruitment completed	Intervention	2024-03-07	<NULL>	<NULL>	7210	Accuvein® effectiveness in successful peripheral intravenous catheterization in adults with Difficult Access: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-08	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6jm5zht	<NULL>	Patient aged 18 years or over. Both genders. Patient who has one of the following characteristics: having undergone two or more attempts at peripheral intravenous access using traditional techniques, having a physical examination suggestive of difficult intravenous access (for example, absence of visible or palpable veins) or having a declared condition or documented history difficult intravenous access.  Be subjected to Peripheral Intravenous Catheterization - PIC on an elective basis, during the day. Peripheral Intravenous Catheterization – CIP for the purpose of administering intravenous solutions or medications. Patients who do not show signs of clinical deterioration immediately before or during the procedure (NEWS-2 Score)	Patients who for some reason give up participating in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:07
RBR-5pzmgxc	Periodontitis in the development of hospital infections	Recruiting	Observational	2024-03-06	<NULL>	<NULL>	6833	Periodontitis in the development of Ventilator-Associated Pneumonia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5pzmgxc	<NULL>	IIndividuals between 18 and 90 years old; both genders; admitted to the Intensive Care Unit of a reference hospital in the macro-region of western Paraná; on mechanical ventilation through the orotracheal tube, within a period of 24 to 72 hours; presenting at least six teeth	Patients with severe maxillofacial trauma, which makes examination difficult; using complete dentures (upper and lower); pregnant women; immunosuppressed; using any anti-inflammatory and antibiotic for more than three days; using anticoagulants; serious medical or surgical complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-9tr6hb4	Use of Autolog for cell salvage to prevent complications of blood loss in liposuctions	Not yet recruiting	Intervention	2024-03-06	<NULL>	<NULL>	6834	Use of Autolog system to prevent complications of blood loss in liposuctions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Hospital Agamenon Magalhaes	Hospital Agamenon Magalhaes	https://ensaiosclinicos.gov.br/rg/RBR-9tr6hb4	<NULL>	Patients aged 18 to 60; both genders;  approved by the hospital&apos;s medical board for liposuction	diabetes mellitus; heart problems; vascular diseases; history of previous surgery in the same area; therapy with anticoagulant; replacement with blood products in the last 90 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-10jht4fw	Relation between strength measurements and thigh muscle function using the Dinabang dynamometer	Recruitment completed	Observational	2024-03-06	<NULL>	<NULL>	6835	Metric properties of torque measurements for different aspects of the muscle function of the knee flexion-extensor mechanism using the Dinabang dynamometer: ¿mother¿ project	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10jht4fw	<NULL>	Individuals with hypokinetic behavior; ages between 18 and 65 years; both genders	Participants who have neurological or cognitive impairments; cardiorespiratory diseases; history of joint or muscle damage in the last six months or during the data collect	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-4m9yf5k	Effect of probiotics and yoga practice on metabolic syndrome in menopausal women	Not yet recruiting	Intervention	2024-03-06	<NULL>	<NULL>	6837	Effect of Probiotics and Yoga Practice on Metabolic Syndrome in Climacteric Women and assessment of associated epigenetic mechanisms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-10	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-4m9yf5k	<NULL>	Climacteric women; age between 40 to 65; diagnosis of metabolic syndrome according to the Joint Interim Statement (JIS) criteria	Diagnosis of lactose intolerance or cancer; women who have engaged in yoga practice within the current or past 12 months; women who have used probiotics within the current or past 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-7w3jw35	Combined Electrical Stimulation of the Brain and Muscles for patients with Spinal Cord Injury: an experimental study	Recruitment completed	Intervention	2024-03-05	<NULL>	<NULL>	6826	Transcranial Electrical Stimulation combined with Neuromuscular Electrical Stimulation in patients with Spinal Cord Injury: quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7w3jw35	<NULL>	Spinal cord injury at any neurological level from C2 to T12 for at least one year. Stable neurological deficit for at least 6 months. Over 18 years of age. Both sexes. Pain at the neurological level of injury or below with a Neuropathic Pain 4 (DN4) scale equal to or greater than 4	Cognitive impairment that prevents the safe completion of electrode training. Neuropathic pain prior to spinal cord injury. Other chronic pain syndromes, especially fibromyalgia and complex regional pain syndrome. Extensive skin lesions that do not allow electrode coupling. Decompensated mood disorder. Epilepsy. Use of a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:58
RBR-5ztk3mw	Effects of the use of Protein Supplements and Physical Exercise in elderly	Recruitment completed	Intervention	2024-03-05	<NULL>	<NULL>	6827	Effects of a Multimodal Intervention on health variables in institutionalized elderly with dietary control: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5ztk3mw	<NULL>	Belong to the institution; be at least 60 years old; able to stand up and move independently; have clinical clearance to carry out activities; follow the standardized meals offered by the institution; agree to sign the Free and Informed Consent Form	Participants who have any type of disease with a previous contraindication or impairment that limits anthropometric measurements and the regular practice of the proposed physical exercises; which are restricted to the bed; underwent surgery recently; had an amputation; have a confirmed medical diagnosis of chronic kidney disease; metabolically catabolic disease; severe neurological and muscle disorders; terminal illnesses; who are in palliative care; make use of nutritionally complete or protein supplements or drugs that affect protein metabolism; who do not consume animal foods; are allergic to milk; have recently experienced significant involuntary weight loss; use an assistive device or any artificial electrical implant; whose nutrition is provided by enteral route or who have contraindications for performing of exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-7c5svrv	Oral Perception and Alzheimer&apos;s disease: long-term evaluation	Recruiting	Intervention	2024-03-05	<NULL>	<NULL>	6828	Oral stereognosis and Alzheimer’s disease: a long-term evaluation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Faculdade de Odontologia de Piracicaba - FOP/UNICAMP	Facultad de Odontología - FOUBA	https://ensaiosclinicos.gov.br/rg/RBR-7c5svrv	<NULL>	Present good general health status or presence of controlled systemic diseases assessed during the anamnesis; be completely edentulous and have unsatisfactory complete dentures according to the Vigild criteria; be between 65 and 80 years old; and normal salivary flow of 0.6 ml/min or more. Patients in the experimental group must meet the criteria mentioned above and have a confirmed diagnosis of mild Alzheimer&apos;s disease by a neurologist using the International Classification of Diseases (ICD-10); Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); Mini Mental State Examination (MMSE); and Clinical Dementia Rating (CDR) with a score of 1.0 or less	Participants with oral lesions; neuromuscular diseases; facial malformations; bruxism (with the presence of an edentulous tongue) and smokers (due to reduced salivary flow) will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-483ndsd	Effectiveness of immersive Virtual Reality on pain perception in children associated with vaccination: randomized pilot study	Data analysis completed	Intervention	2024-03-05	<NULL>	<NULL>	6829	Effect of Virtual Reality on children&apos;s pain perception during vaccination: pilot study of a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-483ndsd	<NULL>	Children between four and six years, 11 months and 29 days; any ethnicity; both sexes; accompanied by parents or legal guardian; received at least one of the five vaccines recommended for the age group; presented cognitive and emotional conditions that enabled the application of the data collection instrument	Child with visual impairment or significant reduction in visual acuity; epilepsy/seizure; pre-existing migraines; changes in sensitivity (decrease or increase) that generated discomfort during the use of virtual reality glasses (labyrinthitis); children with psychiatric illnesses; mood changes diagnosed in an acute state (anxiety and phobias); children with infections; burns or injuries to the face or head that interfered with putting on the immersive virtual reality glasses; strabismus; change in bone shape that made it difficult to adapt virtual reality glasses; having undergone an invasive procedure on the same day as vaccination, withdrawal of participation by the child or parents/legal guardian; presence of nausea; vomiting or other discomfort during the intervention with the immersive virtual reality glasses that did not allow the continued use of the virtual reality glasses; children who used oral, intramuscular or topical (at the site of the intramuscular procedure) analgesics (in less than 12 hours); wished not to use the immersive virtual reality glasses during the intramuscular vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-6dgn572	Effects of Vocal Warm-Up with and without the use of Shaker® in singers	Recruiting	Intervention	2024-03-05	<NULL>	<NULL>	6830	Immediate effects of Vocal Warm-up with and without the use of a Voiced Oral High-frequency Oscillation Device on singers	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-10	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6dgn572	<NULL>	Women choristers active in Belo Horizonte choirs; between 18 and 55 years old; with more than 1 year of choir experience	Smoking choristers; with self-reported vocal complaints; during menstrual period; self-report of disease of cardiovascular origin, hormonal, neurological disease; presence of cleft lips or palate; facial or rib fractures; diagnosed with dysphonia; with vocal complaints; with hearing complaints; diagnosed with hearing loss; with upper airway infection at the time of evaluation; singers in speech therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-6rxswyt	Effects of a booklet on the knowledge, attitude and practice of caregivers of bedridden children and adolescents at home	Recruiting	Intervention	2024-03-05	<NULL>	<NULL>	6831	Effects of educational technology on the knowledge, attitude and practice of caregivers of beed-bed children and adolescents at home: an almost experimental study	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Universidade Estadual do Ceará	Hospital Infantil Albert Sabin	https://ensaiosclinicos.gov.br/rg/RBR-6rxswyt	<NULL>	Main caregiver of the child/adolescent aged 18 or over; know how to read and write	Caregivers who stopped caring for the child/adolescent during the data collection phase; caregivers of children/adolescents who die during the data collection phase; caregivers of children/adolescents who required hospitalization at some stage of the research and caregivers who withdrew from participating in the study at some stage of data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-77r62wz	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Recruitment completed	Intervention	2024-03-05	<NULL>	<NULL>	6832	Evaluation of the gynecological and dermatological acceptability of a Vegetable Ointment product for health under normal conditions of use_Dic01.2023	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-14	IPCLIN - Instituto De Pesquisa Clínica Integrada LTDA	Maredifiori Indústria e Comércio de Cosméticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-77r62wz	<NULL>	Women; age 18 to 59 years; phototype I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; pregnant or lactating women; participants with a history of allergy to the material used in the study; atopy history; use of vaginal cream; participants with a history of allergy to products in the tested category; recent gynecological surgeries; discharges; immunodeficiency carriers; kidney, heart or liver transplants; active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); topical use with corticosteroids in the experimental area up to 8 days before the start of the study.; any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-2vm96f8	Clinical study to verify the best treatment for posterior deciduous teeth: Hall Technique or Resin-Modified Glass Ionomer Cement	Not yet recruiting	Intervention	2024-03-04	<NULL>	<NULL>	6822	Comparison of clinical success between Hall Technique and Resin Modified Glass Ionomer Cement in primary molars: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-05	Bianca Spuri Tavares	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-2vm96f8	<NULL>	Children aged 4 to 8; of both sexes; with at least one primary molar affected by interproximal caries affecting dentin and without signs of pulp involvement; Surfaces with obvious carious lesions will be selected and will include ICDAS (International Caries Detection and Assessment System) code 4 underlying dark shade of dentin; 5 ICDAS (International Caries Detection and Assessment System)  distinct cavity with visible dentin; 6 ICDAS (International Caries Detection and Assessment System)  distinct extensive cavity that exposes dentin	Children who present systemic impairment; Children who are allergic to any dental material to be used; Primary teeth that present spontaneous pain or any indication of pulp involvement such as periapical or interradicular lesions; teeth with a history of trauma; teeth whose roots present more than 1/3 of rhizolysis; teeth with carious lesions located below the free gingival margin; teeth with great coronal destruction that do not allow the use of absolute isolation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-2h86wf5	Impact of the combined application of Advanced-Platelet Rich Fibrin (A-PRF) and low-level laser therapy (LLLT) on healing, discomfort and quality of life in patients undergoing palatal subepithelial connective tissue graft removal.	Recruiting	Intervention	2024-03-04	<NULL>	<NULL>	6823	Impact of the combined application of Advanced A-fibrin-rich plasma (PRF) and Low-level laser therapy (TLBP) on healing, discomfort and quality of life of patients undergoing Palatal subepithelial connective tissue graft removal	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-21	Unioeste - Universidade Estadual do Oeste do Paraná	Unioeste - Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2h86wf5	<NULL>	Age range from 18 to 50 years; both genders; must present tooth(s) with gingival recession that requires surgical treatment with a subepithelial connective tissue graft to be removed from the palate. All teeth in the dental arch must be healthy; with all sites presenting a probing depth of less than or equal to 3mm; with a bleeding rate of less than or equal to 5%; without gingival inflammation and free of carie	Smokers, pregnant and lactating patients, patients with a previous history of periodontal surgery, patients who have used antibiotic therapy in the last six months or who are using antibiotic therapy, steroidal or non-steroidal anti-inflammatory drugs at the time of the study, positive history of any systemic disorder that contraindicate the surgical procedure, teeth with root caries, non-carious cervical lesions or with any type of previous cervical restoration, extruded, rotated, proclined or mobile teeth, endodontic treatment or pulp pathology in the involved tooth and pathogenic occlusal interferences. Each patient&apos;s medical history will be obtained through anamnesis and all participants will undergo a clinical examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-5dbqvhd	Evaluation of the effects of a single dose of Cannabidiol on attention and memory in people with Obsessive Compulsive Disorder	Recruiting	Intervention	2024-03-04	<NULL>	<NULL>	6824	Analysis of the effects of Acute Cannabidiol Administration on Attention and Memory Bias in Patients with Obsessive Compulsive Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-23	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dbqvhd	<NULL>	"Intervention Group: 17 patients diagnosed with Obsessive Compulsive Disorder will be included according to the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, revised text (DSM-5-TR); of both sexes; aged 18 or over; and who do not have any other psychiatric comorbidity
Control Group: 17 subjects will be included without any current or previous psychiatric disorder; of both sexes; and who are 18 years of age or older"	"Intervention Group: Patients who present adverse reactions to the use of the substance or those who do not complete the experimental tasks that make up the study will be excluded.
Control Group: Subjects who present adverse reactions to the use of the substance or those who do not complete the experimental tasks that make up the study will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-9nf6d27	Effects of a digital health education on the knowledge of patients with low back pain about the condition	Not yet recruiting	Intervention	2024-03-04	<NULL>	<NULL>	6825	Effects of an online intervention in patients with low back pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-15	Universidade do Oeste Paulista - UNOESTE	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-9nf6d27	<NULL>	Adults (over eighteen years old); report low back pain without any restriction for duration of symptoms	People unable to understand the Portuguese language; healthcare professionals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-5rq9bd8	Effects of Osteopathic Manual Treatment in Patients with Chronic Low Back Pain	Recruiting	Intervention	2024-03-02	<NULL>	<NULL>	6820	Effects of Osteopathic Manual Treatment protocols in patients with chronic Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-17	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-5rq9bd8	<NULL>	Subjects with lombar pain for at least 03 months, most days	Severe osteoporosis; progressive neurological disease; scoliosis above 30°; reumathic diseases; Laségue positive above 35°; previous lumbar surgery; patient using experimental treatments; patients undergoing another manipulative treatment out of this study; cancer; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-7zsggy2	Red light in skin healing of cancer patients	Recruiting	Intervention	2024-03-02	<NULL>	<NULL>	6821	Physiotherapeutic Approach to the complications of Oncological Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-7zsggy2	<NULL>	Individuals of both sexes; cancer and ending with radiotherapy; I tend to develop radiodermite in any gray	Minors under 18 years of age; metastase na pele; concomitant chemotherapy; infection in the region to be treated; história de doenças de pele ou autoimmunes; history of photosensitivity; inability to answer questions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-54s92mh	Free dance versus Hatha Yoga on quality of life and motor and non-motor symptoms in people with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2024-02-29	<NULL>	<NULL>	6817	The effectiveness of a Free Dance and Hatha Yoga protocol on the motor and non-motor symptoms of people with Parkinson	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-05-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-54s92mh	<NULL>	Clinical diagnosis confirmed by a neurologist following the Movement Disorder Society criteria; both sexes; residents of Florianópolis and São José; on stable doses of medication for the last four weeks; on ON medication; aged 45 years or over; not practicing physical exercise in the month prior to data collection; classified in stages 1 to 4 of PD by the Hoehn &amp; Yahr Disability Scale	Cutoff point of the Montreal Cognitive Assessment (MoCA) instrument for screening, considering ≤ 22 points; classified in stage 5 of PD by the HY Disability Scale; who did not complete all stages of the study; who performed other physical exercise concomitantly; who were not present in up to 75% of the classes.date for enrollment of the first participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-86ycwq7	Influence of a Cleaning Agent on the clinical performance of Resin Restorations in endodontically treated teeth: a clinical study	Not yet recruiting	Intervention	2024-02-29	<NULL>	<NULL>	6818	Influence of Katana mt Cleaner on the clinical performance of Bulk Fill Restorations of endodontically treated teeth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Centro universitário do maranhão-uniceuma	Centro universitário do maranhão-uniceuma	https://ensaiosclinicos.gov.br/rg/RBR-86ycwq7	<NULL>	Participants must be between 18 and 50 years of age; molar with class I and/or II cavity; have an acceptable level of oral hygiene according to the Simplified Oral Hygiene Index (OHI S)19; the cavo-superficial margin cannot involve more than 50% of the tooth enamel; must have two adjacent teeth; presence of the contralateral; the patient accepts the proposed treatment; signed informed consent form	Patients with extremely poor oral hygiene; periodontal index less than 3; xerostomia; orthodontic appliances; intense bruxism; trismus; ankylosis; tooth positioning outside of normal alignment; history of trauma; pregnancy; presence of teeth that require endodontic retreatment; crack in the tooth; existing fractures in the enamel or dentin; tooth support for prosthesis; participants with known allergies to resins or any other material used in the research; patients using anti-inflammatories; analgesics or psychotropic drugs within 15 days of the restorative procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-9qnxb9z	Acupuncture&apos;s effect on blood pressure in Prehypertensive and stage I Hypertensive patients with low cardiovascular risk	Recruiting	Intervention	2024-02-29	<NULL>	<NULL>	6819	Acupuncture&apos;s effect on blood pressure levels in Prehypertensive and stage I Hypertensive patients with low cardiovascular risk	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-15	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9qnxb9z	<NULL>	Patients aged 18 years or over; prehypertensive or stage 1 hypertensive patients at low cardiovascular risk; not taking antihypertensive medication; evaluated at the screening consultation	Patients with stage 2 or 3 arterial hypertension or stage 1 arterial hypertension of moderate or high cardiovascular risk; using any medication with a known influence on blood pressure; diabetics; nephropaths; patients with a history of coronary artery and/or cerebrovascular disease; heart failure and/or thyroid diseases; with any condition that impairs the afferent and efferent conduction of nervous stimulation; severe blood dyscrasias; use of anticoagulants; skin lesions and/or any condition that makes access to the described acupoints impossible; pregnant and lactating women; with not controlled psychiatric illnesses ; who have received antihypertensive drug treatment in the last 6 months or who have already undergone acupuncture at some point in their lives	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-7m7ct53	Influence of spirituality on blood pressure control	Data analysis completed	Intervention	2024-02-28	<NULL>	<NULL>	6816	Influence of spiritual well-being training on blood pressure control	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-27	Liga de Hipertensão Arterial da Universidade Federal de Goiás	Liga de Hipertensão Arterial da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7m7ct53	<NULL>	Hypertensive adults (stage 1 or 2) with low and moderate cardiovascular risk, on stable use of antihypertensive medication for more than thirty days, evaluated by pressure measurements of the last visit.	Stage 3 patient hypertensive	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-3yt94dn	Effects of Low-power Laser Therapy associated with Selective Caries Removal on Postoperative Sensitivity reduction in Deep Cavity Restoration	Recruitment completed	Intervention	2024-02-27	<NULL>	<NULL>	6814	Effects of Photobiomodulation (PBM) associated with Selective Removal Cavity in reduction of Post-operative Sensitivity in Deep Cavity Restorations. A double blind randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal do Pará	Centro Universitário FIBRA	https://ensaiosclinicos.gov.br/rg/RBR-3yt94dn	<NULL>	Vital permanent teeth with class I caries cavities, distance of up to 1mm from the pulp chamber. Good oral and general health conditions.	Teeth that present peripicopathies, sensitivity to percussion, thickening of the periodontal ligament or incomplete rhizogenesis. Spontaneous pain indicative of irreversible pulpitis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-9xbd7b6	Use of florals for anxiety in undergraduate students	Recruitment completed	Intervention	2024-02-27	<NULL>	<NULL>	6815	Use of Flower Therapy for Anxiety in healthcare students: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-04	Universidade Federal da Paraíba - Centro de Ciências Médicas	Universidade Federal da Paraíba - Centro de Ciências Médicas	https://ensaiosclinicos.gov.br/rg/RBR-9xbd7b6	<NULL>	Students of both sexes; aged between 18 and 59 years old; enrolled from the first to the fourth year of the Medicine or Dentistry course at  Universidade Federal da Paraíba - UFPB	Participants who are undergoing flower therapy treatment during the research period; those who have any intolerance/allergy to alcoholic products; or pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-6c9qj8y	Effects of meetings to promote healthy eating habits on the body perception that adolescents have of themselves in a public school in the city of São Paulo/SP	Recruiting	Intervention	2024-02-26	<NULL>	<NULL>	6804	Effects of food and nutrition education actions on the nutritional self-perception of adolescents from a public school in the city of São Paulo/SP	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-02	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6c9qj8y	<NULL>	Students of both sexes; aged between 14 and 19 years old; regularly enrolled in High School at ETEC-GV	Adolescents with non-communicable chronic diseases; diagnosis of eating disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-6zz8pqp	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Recruitment completed	Intervention	2024-02-26	<NULL>	<NULL>	6805	Evaluation of gynecological and dermatological acceptability of health products under normal conditions of use_Ave02.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-02	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Avenca Indústria Cosmética Eireli -EPP	https://ensaiosclinicos.gov.br/rg/RBR-6zz8pqp	<NULL>	Women; age: 18 to 59 years; phototype: I to IV; whole skin of the region; occasional user of category products	kin marks in the experimental area that interfere with the assessment of possible reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; Atopy history; Use of vaginal cream; Participants with a history of allergy to products from the tested category; Recent gynecological surgeries; Discharges; Immunodeficiency patients; Kidney, cardiac or liver transplants; Active skin conditions that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.; Any condition not mentioned above that, in the investigator&apos;s opinion, could compromise the study evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-2k9mkz6	Correlation between clinical and socioeconomic characteristics with the grade of Carpal Tunnel Syndrome	Recruiting	Observational	2024-02-26	<NULL>	<NULL>	6807	Correlation between clinical and socioeconomic characteristics and neurophysiological severity in Carpal Tunnel Syndrome	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-02	Universidade do Estado do Rio Grande do Norte, Faculdade de Ciências da Saúde (FACS)	Instituto André Camurça	https://ensaiosclinicos.gov.br/rg/RBR-2k9mkz6	<NULL>	Patients of both genders; over 18 years of age; referred for electroneuromyography due to suspected diagnosis of carpal tunnel syndrome unilateral or bilateral; with compatible symptoms and confirmation of this diagnosis by electroneuromyography	Patients who have already undergone decompression surgery for carpal tunnel syndrome; patients with concomitant polyneuropathy; patients with amputation of the fingers; patients whose electroneuromyography indicates an other diagnosis than carpal tunnel syndrome; patients with anatomical variations in nervous structures capable of modifying and confusing the median nerve conduction study; patients who cannot tolerate the electroneuromyography exam due to discomfort with electrical stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-75x7wrf	The effects of menopause on metabolic and inflammatory responses after a meal	Recruitment completed	Intervention	2024-02-26	<NULL>	<NULL>	6809	Multi-omics approach for evaluating the effects of menopause on metabolic and inflammatory responses during the postprandial period	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-03-30	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-75x7wrf	<NULL>	The research included participants who were in the postmenopausal period (last menstruation occurred at least 1 year ago) aged between 50 and 70 years, and volunteers of reproductive age from 20 to 40 years, whose body mass index (BMI) varied between 18.5 and 34.9 kg/m²	Volunteers with a history of surgeries that altered the anatomy of the gastrointestinal tract (bariatric surgery, gastrectomy, cholecystectomy), who had inflammatory bowel diseases, celiac disease, gastric ulcers, liver diseases (hepatitis, cirrhosis, etc.), type 1 or 2 insulin dependent diabetes did not participate in the study, casein allergy and lactose intolerance; women using antimicrobial therapy at the time of the study and up to 3 months before the start of the research were not included; other illnesses were evaluated individually, taking into account the pathophysiology of the disease and its impact on research results; women who consumed a maximum of 30g of alcohol per day were allowed to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-9fkncwv	Clinical monitoring of patients with heart failure	Not yet recruiting	Intervention	2024-02-26	<NULL>	<NULL>	6810	Effectiveness of clinical monitoring in the Transition of patients with Heart Failure between health care networks: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9fkncwv	<NULL>	Adults more than 18 years old; with decompensated heart failure with a minimum left ventricular ejection fraction lower than 40 percent; possibility of access to cell phones to receive video calls	Patients on the heart transplant waiting list; who have undergone surgical or percutaneous treatment (coronary or valve) in the last 3 months and with heart failure considered terminal or in palliative care confirmed in medical records; patients with other serious clinical comorbidities with life expectancy less than 1 year confirmed in medical records	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-103p86cv	The impact of using MPFF in improving results in patients with varicose veins under Sclerotherapy	Recruitment completed	Intervention	2024-02-26	<NULL>	<NULL>	6812	The impact of using MPFF 1000mg/day in improving symptoms, complications and quality of life in patients with CVD under sclerotherapy: a prospective randomized study	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2023-05-05	MEDCOG Treinamentos, Locações e Organizações de Eventos em Angiologia e Cirurgia Vascular Ltda	MEDCOG Treinamentos, Locações e Organizações de Eventos em Angiologia e Cirurgia Vascular Ltda	https://ensaiosclinicos.gov.br/rg/RBR-103p86cv	<NULL>	Pacients aged between 18 and 60 years; of both genders; with Chronic Venous Disease – CVD; able to understand and sign (or their representative) the Informed Consent Form ICF	Patients with insufficient perforating veins or saphenous veins (magna and/or parva) detected on ultrasound examination; pregnancy; puerperium; peripheral arterial disease; known thrombophilia; previous history of thrombosis; use of anticoagulants; allergy to polidocanol; active infectio; history of asthma and migraine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-2dfqmr2	Assessment of the knowledge acquired by nursing students on the topic of Leadership through an Online Module	Recruiting	Intervention	2024-02-26	<NULL>	<NULL>	6813	Effect of the Online Module on the acquisition of nursing students&apos; knowledge about Leadership: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-23	Departamento de Enfermagem - Universidade Federal do Rio Grande do Norte	Departamento de Enfermagem - Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2dfqmr2	<NULL>	People aged 18 or over; both genders; being a student in the seventh period of the Universidade Federal do Rio Grande do Norte - UFRN; Nursing course in the semester of 2024.1; have not consumed content on Leadership and/or have not taken the Health Services Management subject or equivalent subject	Students in the seventh period; who have already completed other degrees, stricto sensu or lato sensu postgraduate courses, extension courses, free courses, short courses or events that address the topic of leadership	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-5q5z486	Knowledge, attitudes and practices of primary care professionals on sexual behavior and sexually transmitted infections in the elderly: a quasi-experimental study	Data analysis completed	Intervention	2024-02-23	<NULL>	<NULL>	6800	Knowledge, attitudes and practices of primary health care professionals about sexuality and sexually transmitted infections in the elderly: a quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade do Estado de Mato Grosso	Universidade do Estado de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-5q5z486	<NULL>	Volunteer Nurses; both sexes; unlimited minimum age; working in the municipality&apos;s Primary Care	Nurses on vacation; nurses on leave;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-2kg65g7	Effects of Transcranial Direct Current Stimulation at Different Intensities Associated or Not with Binaural Frequencies on Oxygen Saturation and Reaction Time: Randomized Controlled Study	Not yet recruiting	Intervention	2024-02-23	<NULL>	<NULL>	6801	Effects of Transcranial Direct Current Stimulation at different Intensities associated or not with Binaural Frequencies on Cerebral Hemodynamics and Reaction Time: Randomized Controlled Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-10	Maria de Cassia Gomes Souza Macedo	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-2kg65g7	<NULL>	Young adults aged between 18 and 30; with normal hearing; without a history of neuropsychiatric disorders; without the use of psychoactive substances	Participants with metallic materials implanted in or near the head; with pacemakers or cardiac stents; with active devices where interaction with the electrical field may interfere with their operation; individuals with eczema on the head	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-10bd9x2z	Intestinal flora modulation in the treatment of Arterial Hypertension	Recruiting	Intervention	2024-02-23	<NULL>	<NULL>	6802	The momitha project: modulation of gut microbiota in the treatment of Arterial Hypertension: a randomised, placebo-controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-10bd9x2z	<NULL>	Hypertensive volunteers; both sexes; non-smokers; aged between 20 and 59 years; diagnosed with arterial hypertension for more than one year	Pregnant or breastfeeding women; smoking; kidney failure; dialysis; heart disease; stroke; or heart disease; stroke; autoimmune disease; and the presence of any other medical condition that may interfere with compliance with the with the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-45cbvc3	Physical exercise for people with persistent Covid symptoms	Recruiting	Intervention	2024-02-23	<NULL>	<NULL>	6803	Physical exercise for patients with post-Covid syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-02	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-45cbvc3	<NULL>	Men and women. Age between 18-75 years. Laboratory diagnosis of COVID-19 by RT-PCR, SWAB or serology ≥ 3 months ago. Fatigue or dyspnea associated with post-COVID syndrome in the last week. Access to a smartphone	Severe functional limitation. Participation in a physical exercise program in the last three months. Osteomioarticular problems that prevent physical tests and the training program from being carried out or important osteomyoarticular events during the study, such as muscle injuries that cause exercise limitations. High alcohol consumption, ie, &gt; 14 drinks per week. Smoking. Morbid obesity. Uncontrolled hypertension. Diabetes using insulin or decompensated. Incidence of cardiovascular or pulmonary events during the study. History of major cardiovascular diseases or events. Chronic limiting lung disease. Chronic kidney disease requiring dialysis. Cancer requiring treatment within the last two years. Medical diagnosis of progressive neurological diseases. Illiteracy. Incomplete vaccination schedule against COVID-19	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-7f25wsz	Preservation of the Pubovesical complex in the surgical treatment of Prostate Cancer: effects on the early recovery of Urinary Loss	Recruitment completed	Intervention	2024-02-22	<NULL>	<NULL>	6798	The pubovesical complex-sparing technique on Laparoscopic Radical Prostatectomy: implications on early Urinary Continence recovery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-11	Centro Universitário de João Pessoa	Centro Universitário de João Pessoa	https://ensaiosclinicos.gov.br/rg/RBR-7f25wsz	<NULL>	Patients with low and intermediate risk prostate cancer (National Comprehensive Cancer Network); age below 75 years; normal preoperative continence	Preoperative urinary incontinence; prostate volume greater than 80 ml; use of neoadjuvant therapy; prostate, bladder or urethral surgery; biopsy with involvement of the anterior region of the prostate; vascular or neurological comorbidities with voiding or sexual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-4gzhy4s	Efficacy of the Feuerstein Instrumental Enrichment (FIE) program level 1 in people diagnosed with Schizophrenia after the first Outbreak	Recruiting	Intervention	2024-02-22	<NULL>	<NULL>	6799	Efficacy of the Feuerstein Instrumental Enrichment (FIE) program level 1 in people diagnosed with Schizophrenia after the first Psychotic Episode	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4gzhy4s	<NULL>	The patient must be clinically stable according to medical criteria and undergoing antipsychotic medication treatment; following the first psychotic episode; having been diagnosed with schizophrenia; in accordance with the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition; the psychiatric diagnosis will be confirmed using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders Fifth Edition; be between 18 and 40 years of age; have a minimum estimated IQ of 70; be capable of signing the informed consent form	Inability to communicate sufficiently in Portuguese to undergo the tests and participate in cognitive intervention; present any underlying organic or neurological condition affecting cognition; such as neurological injuries or seizures or traumatic brain disorders; diagnosis of intellectual disability IQ less than 70; chemical dependence or substance abuse including alcohol and drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-6jcj8k3	Assessment of uterine scar immediately after cesarean section. Influence of wire with barbs on ultrasound of the scar defect	Recruitment completed	Intervention	2024-02-21	<NULL>	<NULL>	6797	Early assessment of cesarean section scar. Influence of Barbed Wire on the ultrasound characteristics of the Niche	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-12	Faculdade de Medicina - Universidade Federal de Mato Grosso do Sul	Hospital Universitário Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-6jcj8k3	<NULL>	Pregnancy. Age 18 years old and over. Without cesarean section	Uncontrolled gestational diabetes. Peripartum anemia. Chronic use of corticosteroids. Multiple pregnancy. Polyhydramnios. Domicile outside the city of Campo Grande. Mullerian anomalies. Placenta previa. Chronic inflammatory disease. Chorioamnionitis. Fever of any nature. Infection in the topography of the incision. Myoma at the hysterotomy site. Uterine incision in the body segment. More than 2 extra stitches for hemostasis. Endometritis. Uterine resuturing in the postpartum. Use of corticosteroids up to 30 days postpartum	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-4nm87k2	Clinical Simulation for training health professionals in assistance in the first hour of labor and birth	Not yet recruiting	Intervention	2024-02-21	<NULL>	<NULL>	7227	Effectiveness of Clinical Simulation for training health professionals in assistance in the first hour of labor and birth: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-09-01	Faculdade de Enfermagem da Universidade Federal de Goiás	Secretaria da Saúde do Estado de Goiás - Leide das Neves Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-4nm87k2	<NULL>	Health professionals in the obstetric area working in direct assistance to parturient and postpartum women and newborns in the following sectors: Obstetric Emergency, Surgical Center, Normal Delivery Unit and Joint Accommodations; be contactable by telephone; have access to the internet at home or on your cell phone; both genders	Health professionals who, during the period of data collection, are on vacation, or on sick leave, or away from care or serving prior notice; professionals who, after three attempts, are not on their original shift according to the duty schedule; professionals who have already participated in a Clinical Simulation course for Postpartum Hemorrhage (PPH)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:13
RBR-8fvmt99	Effects of Health Self-Management Strategies on biological, psychological and social aspects of people with Rheumatological Diseases	Not yet recruiting	Intervention	2024-02-20	<NULL>	<NULL>	6795	Effects of a health self-management strategy protocol on biophychosocial aspects of individuals with rheumatological diseases: a single-blinded randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8fvmt99	<NULL>	Volunteers diagnosed with any rheumatological disease; Are not undergoing any type of physiotherapeutic treatment; Older than 18 years; Both genders	History of recent fracture (last 3 months); Have participated in any therapies in the last 3 (three) months; Inability or interruption during functional tests; Perform more than 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity per week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-3bwg6qx	Relationships between Cognitive Aspects and Emotional Regulation: Study with Adults with and without Depression	Recruitment completed	Intervention	2024-02-20	<NULL>	<NULL>	6796	Relationships Between Executive Functions, Metacognition and Emotional Regulation: A Study with Adults with and without Depression	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-3bwg6qx	<NULL>	Age ranging from 18 to 40 years; who met the DSM-V criteria for a diagnosis of major depression based on a previous medical or psychological evaluation; who had a minimum score of 20 on the Beck Depression Scale; participants could be using antidepressants or not, once they were using them, the medication should have been stable for at least one month	People who underwent medication adjustment in the last 30 days; who use benzodiazepines with a dosage greater than 20 mg; who have other psychiatric, neurological or motor diseases; who have some type of neurodevelopmental disorder; people who have metal in the skull or skin lesions on the scalp; pregnant women; or people who abuse alcohol or drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-58j572j	Comparative Study for the Feasibility of a Device for Non-Invasive Clinical Analysis	Recruiting	Intervention	2024-02-20	<NULL>	<NULL>	8248	Comparative Clinical Trial for the Viability of the Progenos® Medical Device	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Nanotimize Tecnologia Ltda.	Nanotimize Tecnologia Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-58j572j	<NULL>	Men or women with no age limit; be able to sign the ICF approved by the CEP and execute and understand all study procedures and instructions.	Subjects who do not agree to participate in the clinical trial and do not sign the ICF.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:49
RBR-106bhhcy	Trial study of a Treatment of Behavior Change in the practice of walking exercise in people after Stroke	Not yet recruiting	Intervention	2024-02-19	<NULL>	<NULL>	6793	Intervention protocol based on the Theory of Self-Determination on the adherence of individuals after Stroke to the recommendation for walking exercise: A randomized feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-18	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-106bhhcy	<NULL>	Individuals ≥18 years old; ≥ six months after a stroke (ischemic or hemorrhagic); who can understand simple commands, assessed through the Mini Mental State Examination (MMSE) (score greater than 13 points for illiterate, 18 points for low/medium education, and 26 points for others); being able to walk independently with an auxiliary device or not;;having access to smartphone and internet with a minimum volume of 3G	Significant cardiovascular conditions (uncontrolled resting hypertension or uncontrolled metabolic disease); lower limb orthopedic problems that make walking impossible; perform &gt;150 minutes of walking per week on a scheduled basis at moderate intensity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-96ch27c	Methylene Blue as a Vasoplegic Syndrome preventive agent in cardiac surgeries	Recruiting	Intervention	2024-02-17	<NULL>	<NULL>	6790	Prophylactic administration of Methylene Blue in patients at high risk for the Vasoplegic Syndrome in Cardiac surgery: randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-08-16	Hospital das clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-96ch27c	<NULL>	Age 18 years or older; cardiac surgery with cardiopulmonary bypass; EUROSCORE II between 4% and 15%; patient undergoing double valve repair and/or double valve replacement surgery or reoperation in valve surgery or combined surgery (coronary bypass graft with valve surgery) or valve replacement due to endocarditis.	Refusal to participate in the study; patient involved in another clinical trial; emergency surgery; minimally invasive or transcatheter cardiac surgery; cardiac surgery with no cardiopulmonary bypass; change in surgical planning, such as single valve replacement/repair or isolated revascularization; previous or current use of selective serotonin reuptake inhibitor drugs, or selective and non-selective monoamine oxidase inhibitor drugs, or non-selective heterocyclic monoamine reuptake inhibitor drugs; patient with glucose-6-phosphate dehydrogenase deficiency or other hemolytic disease; previous history of hypersensitivity to methylene blue; acute liver dysfunction; pregnancy or potential risk of pregnancy; current use of vasoactive amines.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-37qx63d	Assessment of the tolerance and safety of Prescription of different doses of Psilocybin in Healthy adults.	Not yet recruiting	Intervention	2024-02-17	<NULL>	<NULL>	6791	Assessment of the tolerability and safety of Administration of different doses of Psilocybin in Healthy adults.	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2024-05-01	Biocase Brasil	Instituto Alma Viva	https://ensaiosclinicos.gov.br/rg/RBR-37qx63d	<NULL>	Adults without comorbidities aged between 21 and 65 years from both gender	Participants who meet any of the following exclusion criteria are not eligible for the study including use of medications that may interfere with the study drug, history of heart, liver, kidney disease, history of cancer or organ transplant, insulin dependent diabetes or uncontrolled diabetes, gastrointestinal disease that may interfere with the absorption of the substance orally, current or past history of psychiatric disorders as schizophrenia, psychotic disorder, bipolar disorder, personality disorder, first degree family history of psychiatric disorders, seizures or fainting, creatinine elevation, nicotine dependence that would prevent an individual from being nicotine-free for 7 to 10 hours during the dosing period, women who are pregnant or intending to become pregnant during the study or who are currently breastfeeding, chemical dependency or abuse of alcohol or illicit drugs in the last 12 months, platelets disorders,  clinically significant anemia, liver injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-2pmkjw7	Effects of Combined Exercise Training before treatment in women with Breast Cancer	Recruiting	Intervention	2024-02-17	<NULL>	<NULL>	6792	Combined physical training for women undergoing oncology care at CAISM Mastology	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti. Universidade de Campinas - UNICAMP	Escola de Educação Física e Esporte - EEFE. Universidade de São Paulo - USP.	https://ensaiosclinicos.gov.br/rg/RBR-2pmkjw7	<NULL>	Women diagnosed with invasive breast carcinoma;  age greater than or equal to 18 years; disease stage within I to III	Having undergone previous treatment for cancer; having actively participated in a structured physical training program for a minimum duration of 6 months; self-report inability to engage in physical exercise; medical contraindications for physical exercise; and pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-10mn89c6	Insertion of a copper IUD after immediate vaginal delivery: comparison between placement with and without the aid of ultrasound	Recruiting	Intervention	2024-02-16	<NULL>	<NULL>	6789	Copper IUD insertion after immediate vaginal delivery: comparison of standard technique vs. ultrasound-guided technique - a randomized double-blind study carried out in university hospital	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-02	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10mn89c6	<NULL>	Pregnant women with a single fetus. Age over 18 years old. Gestational age greater than or equal to 34 weeks. Pregnant women admitted to an obstetric center in early labor (&lt; 4 cm cervical dilation) or under labor analgesia, able to understand the study presentation, its justification and sign the informed consent form. Pregnant women expressing a desire to insert an IUD prior to the study inclusion interview	Puerperal sepsis. Chorioamnionitis. Distorted uterine cavity (submucous myoma, Mullerian malformations). Cervical cancer. Fever (oral temperature ≥ 37.8º C) during labor. Rupture of ovular membranes ≥ 18 hours. Puerperal hemorrhage when any type of intervention is performed for puerperal hemorrhage: Manual massage, Administration of crystalloid for volume expansion or blood derivatives. Use of medications such as oxytocin, ergotamine, misoprostol, tranexamic acid. Use of intrauterine balloon. Surgical treatment such as vessel ligation and B-Lynch.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-7kyk2wy	Investigation of mechanisms involved in exercise intolerance in patients with long-Covid	Recruiting	Intervention	2024-02-15	<NULL>	<NULL>	6786	Pathophysiology of exercise intolerance in Long Covid: an integrated investigation of cardiorespiratory, muscular, metabolic and neurological mechanisms	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-11-01	Disciplina de Pneumologia da Universidade Federal de São Paulo	Hospital São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7kyk2wy	<NULL>	Adult individuals; minimum age 18 years; of both sexes; with persistent symptoms after 3 months of Covid19 infection and with right ventricular preload dysfunction (defined by a right atrial pressure at peak exercise &lt;7 mmHg assessed during an Invasive Cardiopulmonary Exercise Testing - iCPET)	Patients who are unable to perform cycling exercise in order to perform an Invasive Cardiopulmonary Exercise Testing (iCPET) correctly, either due to neuromuscular limitation or due to musculoskeletal limitation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-9r2p93z	Multidisciplinary approach based on Physical Activity and Healthy Eating in caring for children with Obesity	Recruiting	Intervention	2024-02-15	<NULL>	<NULL>	6787	Multidisciplinary approach based on Lifestyle Changes in caring for children with Obesity	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-25	Universidade do Estado do Rio de Janeiro (UERJ)	Laboratório de Pesquisas Clínicas e Experimentais, Centro Biomédico, UERJ	https://ensaiosclinicos.gov.br/rg/RBR-9r2p93z	<NULL>	age group between 5 and 13 years old; impubescent or at the beginning of puberty	previous participation in weight loss program; endocrine or genetic obesity; metabolic diseases; previous heart, respiratory, liver and kidney diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-7b43sfr	Personalized nutrition: dietary intervention to reduce the risk of cardiometabolic diseases using knowledge-based system technology	Not yet recruiting	Intervention	2024-02-15	<NULL>	<NULL>	6788	Precision nutrition: personalized intervention to reduce the risk of cardiometabolic diseases using a knowledge-based system	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-02	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7b43sfr	<NULL>	Volunteers of both sexes; age between 20 and 59 years	Drug users; vitamin and or mineral supplementation; menopausal women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-6rrc63n	Effects of Aromatherapy on women with climacteric symptoms	Not yet recruiting	Intervention	2024-02-14	<NULL>	<NULL>	6783	Effects of Aromatherapy with Lippia alba (Mill.) N.E. Brown essential oil on climacteric symptoms: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Susy Maria Feitosa de Melo Rabelo	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6rrc63n	<NULL>	Interest in participating in the study; age between 40 and 65 years; presence of one or more climacteric symptoms, reported from the Blatt and Kupperman Menopausal Index and with moderate to intense intensity; Menopause occurred no more than 5 years ago; Preserved cognitive function, assessed using the Mini Mental State Examination.	Women who have any speech articulation or hearing problems that prevent them from responding to the research instruments and participating in the intervention; Presence of dermatological lesions or considerable deformities in the nose, in addition to already recognized anosmia; Women who have undergone aromatherapy treatment or other PICS in the last month; Women using anxiolytic substances in the last month, such as: benzodiazepines, antihistamines, hypnotics, sedatives, antidepressants, antipsychotics, stimulants and corticosteroids; Women using hormone replacement therapy (HRT) in the last 3 months prior to the intervention; Previous clinical diagnosis of chronic diseases, such as: diabetes mellitus, systemic arterial hypertension, cardiovascular diseases, cancer, seizures, epilepsy and so on, decompensated; Women using antithrombotic medication, as drug interactions with Lippia alba are known; Recognized hypersensitivity after using Lippia alba in other formulations (teas, infusions, creams, lotions, shampoos, etc.); Users of Lippia alba essential oil.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-9f37b4h	Comparison between restorations with Polyethylene Fiber and Cusp Coverage in non-vital posterior teeth: a randomized clinical trial	Recruitment completed	Intervention	2024-02-14	<NULL>	<NULL>	6784	Clinical evaluation of restorations with Polyethylene Fiber as an alternative to Cusp Coverage in non-vital posterior teeth: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-15	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9f37b4h	<NULL>	Patients must be at least 18 years old, in good general and oral health; Dental elements of the study should have a premolar or molar with satisfactory endodontic treatment, loss of at least one proximal wall, being in occlusion and having adjacent teeth, have a coronary structure remaining from the buccal or palatal/lingual walls with at least one cavity wall with a thickness of &lt;2mm	Patients with poor oral hygiene will be excluded from the study; smokers; pregnant women; teeth that have color changes due to intrinsic factors (dentinogenesis and amelogenesis imperfecta, fluorosis, tetracycline); periodontal disease; severe parafunctional habits and active clasps of removable partial dentures in the tooth included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-10rmpmtn	Effects of four non-invasive Neuromodulation methods on Sexual Diseases : randomized clinical trial	Recruiting	Intervention	2024-02-12	<NULL>	<NULL>	6782	"Analysis of the neurophysiological and biomechanical effects of four methods of
non-invasive Neuromodulation in Sexual Diseases: randomized clinical trial"	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-12-20	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-10rmpmtn	<NULL>	women aged between 20 and 45 years; who report a persistent or recurrent complaint for at least six months of at least one of the criteria of the Diagnostic and Statistical Manual of Mental Disorders (Appendix C), 5th edition of the American Psychiatric Association (2014), namely: 1) significant pain during intercourse or penetration attempts; 2) significant fear or anxiety about pain in anticipation of, during, or because of vaginal penetration; 3) stiffness or significant tightening of the pelvic floor muscles during attempts to penetrate the vagina, which represents significant suffering due to the presence of one of these criteria	women who are being treated for pelvic genital pain/penetration with the administration of anesthetic creams in the vulvovaginal region; urinary tract infection; history of epileptic or convulsive conditions; who use drugs to treat epilepsy; presence of metal implants, trauma or surgery in the head and/or neck region; intellectual disability; pregnancy; alcohol and hallucinogenic drug abuse in the last six months; who are undergoing cancer treatment with radiotherapy; and women who miss some day of the therapy proposed in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-10p6b57j	The effect of Pilates Method and French Auriculotherapy on body image, autonomic function, cerebral electrical activity, anxiety, and quality of life in post-COVID-19 patients	Recruitment completed	Intervention	2024-02-10	<NULL>	<NULL>	6780	Body Image, Autonomic Function, Cerebral Electrical Activity, Anxiety, and Quality of Life in Post-COVID-19 Patients Undergoing an Exercise Program with Pilates Method and French Auriculotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-03	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-10p6b57j	<NULL>	Volunteers presenting post-COVID-19 syndrome; age ranging from 30 to 70 years; both genders; alteration in body image perception as defined by the Body Dysmorphic Disorder Examination (BDDE), individuals with scores higher than 66 (SEGUETO, 2011); anxiety alteration above 20 points on the State-Trait Anxiety Inventory - STAI and above 20 on the salivary amylase evaluation	Presence of other musculoskeletal diseases that prevent the active performance of the proposed exercises; central and peripheral injuries; failure to meet any of the inclusion criteria factors; lack of consent to participate in the project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-108b5jqc	Blue LED in the treatment of skin lesions caused by Radiotherapy	Recruiting	Intervention	2024-02-08	<NULL>	<NULL>	6777	Effects of Blue LED Photobiomodulation in the prevention of Radiodermatitis in oncology patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-108b5jqc	<NULL>	Men and women; older than 18 years; diagnosed with cancer referred to the Santa Maria University Hospital physiotherapy outpatient clinic for physiotherapeutic treatment; with indication of radiotherapy	Unable to understand guidelines, such as those regarding the effects, protocol and care; volunteers who miss three more sessions; patients who have already received radiotherapy sessions; with skin cancer; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-2rvwstz	Efficacy of cardiac biofeedback in control shortness of breath and improving functional capacity in COVID-19 survivors	Other	Intervention	2024-02-08	<NULL>	<NULL>	6778	Efficacy of Cardiac Biofeedback in Controlling Dyspnea and improving Functionally Capacity in post covid syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-29	Unifacisa	Universidade Federal de São Carlos- UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-2rvwstz	<NULL>	Patients who prove RT-PCR negative for COVID-19 performed at the place of hospitalization following criteria for hospital discharge; who developed a moderate to severe form of the disease; who were hospitalized and admitted to an intensive care unit (ICU) will be included in the study, intermediate care unit or ward; undergoing invasive (via orotracheal tube or tracheostomy) or non-invasive mechanical ventilation and oxygen therapy (high-flow nasal atheter or mask with reservoir bag); who were discharged at least 30 days before the start of rehabilitation.	Participants who certify reinfection, rehospitalization and hospital admission will be excluded from the study; hemodynamically unstable patients (uncontrolled blood pressure and heart rate); unstable medical conditions (e.g., cardiovascular and pulmonary disorders - arrhythmias, decompensated atrial fibrillation, pulmonary thromboembolism, acute heart failure, pulmonary congestion, acute myocardial infarction and stroke); with severe pulmonary, cardiac or functional sequelae that require a more complete rehabilitation program, or cognitive conditions; dementia that makes it impossible to answer the questionnaires; finally those with confirmed mental disorders and who require sychological intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-5mtk9d8	Biological and Empathy effects after Communication Training in health professionals	Recruiting	Intervention	2024-02-08	<NULL>	<NULL>	6779	Neurobiological Modulation and Empathy in Improving Health Communication Skills	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5mtk9d8	<NULL>	Medical students aged between 18 and 45 will be included in the sample in any period of training. All participants must sign the Free and Informed Consent Form – TCLE	Having participated in some interpersonal communication training or similar, individuals who attended less than 75% of the interventions during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-82p87rq	Association of weakness and low muscle mass with clinical outcomes in hemodialysis patients: SARC-HD project	Recruitment completed	Observational	2024-02-07	<NULL>	<NULL>	6774	Sarcopenia and its association with clinical outcomes in Hemodialysis patients: SARC-HD project	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-01	Centro Universitário ICESP	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-82p87rq	<NULL>	equal or older than 18 years; hemodialysis treatment for at least three months.	Inability or refusal to sign/provide the informed consent form; Any impairment that compromises participation in the study, such as cognitive impairment, locomotor and/or neurological disorders; Change of renal replacement therapy or clinical center (non-partner) during the data collection phase, in a previously planned way, or during the follow-up; Medical contraindication for carrying out the battery of physical tests; Permanent pacemaker (contraindication to bioimpedance measurement); Uncontrolled heart disease, cardiovascular surgery, or recent hospitalization (one month before baseline).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-25g4gt6	The impact of Exercise on Chemotherapy Symptoms in cancer patients	Recruiting	Intervention	2024-02-07	<NULL>	<NULL>	6775	Physical Exercise and Symptomatology Associated with Chemotherapy Treatment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Estadual do Centro Oeste	Hospital de Caridade São Vicente de Paulo	https://ensaiosclinicos.gov.br/rg/RBR-25g4gt6	<NULL>	Adult patients (above 18 years old) undergoing chemotherapy treatment. Patients diagnosed with solid cancer who require regular chemotherapy infusions. Adequate physical condition to perform aerobic exercise during the infusion, as assessed by a healthcare professional. Ability to understand and follow study instructions. Availability to regularly participate in chemotherapy sessions during the study period.	Patients with medical contraindications for engaging in physical exercise. Presence of severe medical conditions, in addition to cancer, that may interfere with participation in the study or the ability to perform exercises during the infusion. Significant physical incapacity that hinders the safe execution of exercises. History of serious cardiac problems or recent cardiac events. Participation in other research studies simultaneously. Psychological or emotional conditions that may negatively affect participation in the study or adherence to the exercise protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-33f4vgr	The effect of Cannabinoid use on Neuropathic Pain in Low Back Pain	Recruiting	Intervention	2024-02-06	<NULL>	<NULL>	6773	Evaluation of the effectiveness of the use of Cannabinoids in controlling Neuropathic Pain in Low Back Pain	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2024-01-17	Carmens Medicinal	Carmens Medicinal	https://ensaiosclinicos.gov.br/rg/RBR-33f4vgr	<NULL>	Patients undergoing follow-up at the Spine Surgery and/or Antalgic Therapy and Palliative Care Outpatient from the Hospital of the Faculty of Medicine of Botucatu with pain in the lumbar spine with associated sciatica (low back pain); Age between 18 and 75 years; Be able to respond to the questionnaires proposed in the research; both genders.	Pregnant women; Patient with fracture or neoplastic lesion; Patients with pathologies that cause electrolyte disorders; Cognitive inability to adequately respond to questionnaires; Disagree with the free and informed consent form; Patient with low back pain without sciatica; Recreational users of illicit substances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-32k3mjp	Use of Transcranial Direct Current Stimulation in women with menstrual cramps	Recruiting	Intervention	2024-02-06	<NULL>	<NULL>	7924	Transcranial Direct Current Stimulation in women with Primary Dysmenorrhea: usability and clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-32k3mjp	<NULL>	Women with age between 18 to 45 years; medical diagnosis of primary dysmenorrhea; mean pain equal to or greater than 4 on the Visual Analog Pain Scale; regular menstrual cycle of 28 to 32 days	History of head trauma; epilepsy; alcohol dependence; nicotine or drug addiction; pregnancy diagnosis; chronic urinary and intestinal diseases; metallic implant; pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-29mzk3h	Efficacy of combined bleaching in adult patients with aesthetic composite resin restorations: impact on tooth sensitivity and quality of life	Recruiting	Intervention	2024-02-02	<NULL>	<NULL>	6770	Tooth Sensitivity, impact on quality of life, and efficacy of combined bleaching in adult patients with direct esthetic restorations in composite resin: a controlled clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-30	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-29mzk3h	<NULL>	At least 40 years old; both genders;  to have central incisors of shade A2 or darker; to have or haven&apos;t direct composite restorations in the anterior teeth; vital teeth (from premolar to premolar in both arcades); have good general and oral health	Smokers; bruxists; pregnant or breastfeeding women; severe intrinsic dental pigmentation (tetracycline stains, fluorosis); teeth undergoing orthodontic treatment; gingival recession and cervical dentin exposure with previous sensitivity (from teeth 15 to 25 and from teeth 35 to 45); presence of visible enamel cracks; history of spontaneous sensitivity; endodontic treatment (from teeth 13 to 23 and from 33 to 43)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-57pn44w	Study of the effects of Acupuncture on individuals who do not practice physical exercise	Recruitment completed	Intervention	2024-02-02	<NULL>	<NULL>	6771	Double-blind randomized clinical trial of Acupuncture with monitoring of Thermography, Hematology, Bioimpedance and Ryodoraku	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Anhembi Morumbi/ Instituto Superior de Comunicação	Universidade Anhembi Morumbi/ Instituto Superior de Comunicação	https://ensaiosclinicos.gov.br/rg/RBR-57pn44w	<NULL>	Healthy female and male people; over 18 years old; sedentary; that do not have pre-existing metabolic changes; who have not previously applied acupuncture	Volunteers who have metabolic syndromes; hepatic steatosis; diabetes; hypothyroidism; hyperthyroidism; hypertension; pregnant women; postpartum women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-4sv4b8n	Improvement of Anxiety and Stress in Pregnant patients in the practice of the Six Healing Sounds and Conscious Breathing	Not yet recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6764	Management of Anxiety and Stress in Pregnancy Practice of Six Healing Sounds and Conscious Breathing randomized clinical trial and controlled	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-20	Clínica Cinesiopelvica - CC	Pessoa física responsável Roberta Pitta Costa Luz	https://ensaiosclinicos.gov.br/rg/RBR-4sv4b8n	<NULL>	Criteria pregnant women between 18 and 40 years old;  with a single pregnancy	Diagnosis of psychiatric illnesses: depression and/or anxiety; with pregnancy complications; risk pregnancy; who use mood-moderating medications; who practice yoga, meditation and mindfulness techniques, as they offer satisfactory results in controlling anxiety, it was decided to exclude pregnant women who practice these techniques	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-9r68r8y	Comparison of laparoscopic versus robot-assisted treatment for achalasia	Not yet recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6765	Comparison of Laparoscopic versus Robot-assisted Cardiomyotomy with Fundoplication for Achalasia treatment: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9r68r8y	<NULL>	Patients with achalasia; patients with indication for surgical treatment (with Eckardt ≥3); age between 18 and 65 years old; male and female sex	Patients who refused to participate in the study; pregnant patients; patients who have any contraindication to general anesthesia or laparoscopic intervention; morbid obesity (BMI&gt;30 kg/m2); patients undergoing previous diaphragmatic hiatus surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-472dvp3	Effect of Auriculotherapy and Laser on pain treatment in patients treated at the family health unit	Recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6766	Effect of Auricular Acupuncture and Low Frequency Laser in the treatment of Pain in patients assisted in primary health care: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-472dvp3	<NULL>	Individuals aged 18 or over; that is accompanied by a Family Health Strategy (ESF); presents availability of place for treatment; who self-reports pain with greater intensity4 on the Visual Numerical Scale (VNS); in addition, agree to the Free and Informed Consent Form (TCLE)	Patients who; are continuously using pain relief medication; infection; inflammation or injury to the ear; anatomical changes in the hearing aid; allergy to crystals or microporous tape; undergoing treatment with energy therapies or that have been carried out in the last three months (such as, for example, aromatherapy; Bach flower remedies; systemic acupuncture; foot reflexology; homeopathy); pregnant women; and missing more than two consecutive sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-88shyrm	Effectiveness of phonation in tubes submerged in water performed via Telehealth and face-to-face: randomized blinded clinical trial	Recruitment completed	Intervention	2024-02-01	<NULL>	<NULL>	6767	Effectiveness of the Water Resistance Therapy Protocol performed via Telehealth and face-to-face: randomized blinded clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-14	Faculdade de Odontologia de Bauru	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-88shyrm	<NULL>	Participants of both genders; aged between 18-50 years old; with moderate vocal deviation; with otorhinolaryngological diagnoses of behavioral dysphonia; and who have never go through vocal therapy or the period without vocal therapy is equal or superior to six months.	Participants who are smokers; pregnant; in menopause; had undergone surgery in the neck and larynx; presented signs of psychogenic dysphonia; and have any auditory impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-686kmpz	Use of Cannabidiol in the treatment of psychiatric symptoms of Vascular Dementia	Recruitment completed	Intervention	2024-02-01	<NULL>	<NULL>	6768	Effects of Cannabidiol on behavioral and psychological symptoms of Vascular Dementia	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2021-08-06	Faculdade de Medicina de Ribeirão Preto- Universidade de São Paulo (FMRP-USP)	Faculdade de Medicina de Ribeirão Preto- Universidade de São Paulo (FMRP-USP)	https://ensaiosclinicos.gov.br/rg/RBR-686kmpz	<NULL>	Being 60 years of age or older; both genders; diagnosis of Vascular Dementia; obtain at least 4 points in the Neuropsychiatric Inventory; having a formal or informal caregiver capable of properly informing the patient&apos;s status and controlling drug administration; be able to return for reassessments when necessary and have a telephone for daily contacts; stable dose for at least 30 days of psychotropic medications	Clinical instability; use of warfarin, clobazam, valproic acid, anti-inflammatory or anticancer medications; alcohol use; Delirium	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-96h3k97	Effects of Electric Current on pain after Breast Augmentation surgery: placebo research protocol	Not yet recruiting	Intervention	2024-02-01	<NULL>	<NULL>	6769	Effects of Transcutaneous Electrical Nerve Stimulation on the intensity of acute postoperative pain in Breast Augmentation: a randomized, placebo-controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Centro de Ciências Biológicas e da Saúde -  Universidade Federal de São Carlos	Centro de Ciências Biológicas e da Saúde -  Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-96h3k97	<NULL>	Women; aged between 18 and 65; Requests for breast augmentation surgery using the 24-hour rapid recovery protocol; report a pain intensity significantly equal to or greater than 3 points on the Numerical Pain Scale in the immediate postoperative period	Chronic diseases; previous experience with electrical currents for pain; history of use of illicit and psychotropic drugs; chronic use of opioids; presence of a cardiac pacemaker; neurological disorders that interfere with the level of consciousness; changes in previous skin sensitivity in the breast; inability to support the shoulder elevated at 90 degrees	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-92784wr	Use of tansagem, as a mouthwash, in cancer-related lesions	Recruitment completed	Intervention	2024-01-30	<NULL>	<NULL>	6755	Use of Plantago major L. extract rinse in oral mucositis related to Cancer	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-03-20	Universidade Federal da Fronteira Sul - UFFS	Universidade Federal da Fronteira Sul - UFFS	https://ensaiosclinicos.gov.br/rg/RBR-92784wr	<NULL>	Male and/or female patients diagnosed with cancer undergoing chemotherapy; over 18 years old;  who have some degree of mucositis according to the World Health Organization	Pacients who had hematological disorders;  were undergoing treatment with antibiotics, antivirals, antifungals or monoclonal drugs; who had some type of allergy to the components of rinse formulations ; who had previously undergone laser therapy for mucositis lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-3n49nsj	Use of self-care supportedcin the management of diabetes mellitus in primary attention	Data analysis completed	Intervention	2024-01-30	<NULL>	<NULL>	6756	Self-care supported in the management of Diabetes Mellitus in primary care: intervention and assessment	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-02	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3n49nsj	<NULL>	Be registered in the Family Health Units (USF) included in the study with a diagnosis of Type 2 Diabetes Mellitus; of both sexes; older than 18 years	Have a health problem that makes verbal communication difficult/impossible and/or traveling to the Family Health Units; not have telephone contact; change of coverage area of ​​the Family Health Units during data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-8xg74vp	Effects of resistance training in Systemic Sclerosis	Recruiting	Intervention	2024-01-30	<NULL>	<NULL>	6759	Effects of lower limbs resistance training on strength, muscle mass and physical function in Systemics Sclerosis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-15	Hospital de Clínicas de Porto Alegre	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-8xg74vp	<NULL>	Women; minimum age 45 years; diagnosis of Systemic Sclerosis according to the American College of Rheumatology	Overlapping autoimmune diseases, except sjögren syndrom; use of ergogenic resources; uncontrolled heart or circulatory disease; palpitation; pulmonary artery systolic pressure (PASP) &gt; 35mmHg; forced vital capacity (FVC) &lt; 70% of estimated; inability to adhere to home-based training; inability to understand and sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-2pd4s4q	Effect of the maxillary expander device on the size of the nasal cavity	Recruiting	Intervention	2024-01-30	<NULL>	<NULL>	6760	Comparison between the differential opening maxillary expander and the Hyrax expander for pediatric Obstructive Sleep Apnea: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2pd4s4q	<NULL>	Children aged 6 to 12; both genders; presence of Class I or II malocclusion with unilateral or bilateral posterior crossbite; high-risk diagnosis for sleep-disordered breathing according to the Pediatric Sleep Questionnaire (PSQ)	Presence of Class III malocclusion; patients with craniofacial syndromes; history of previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-9459thb	The effect of Thechology in the promotion of Oral Health	Recruiting	Intervention	2024-01-30	<NULL>	<NULL>	6761	The impact of the use of Technology in the promotion of Oral Health - a multicenter study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-17	Thais Maria Freire Fernandes Poleti	Universidade para o Desenvolvimento do Estado e da Região do Pantanal (Uniderp)	https://ensaiosclinicos.gov.br/rg/RBR-9459thb	<NULL>	Age between 15 and 35 years; having natural teeth and the possibility of revealing dental biofilm with 0.5% basic fuchsin; have a cell phone or tablet with internet access and the possibility of using applications; collaborative behavior during dental care; level of cognition that allows the instruction and application of the oral hygiene methodology	Totally edentulous patients or patients with several dental faces restored or covered with prosthetic pieces; physical or mental alteration that makes it difficult for outpatient dental care (advanced Alzheimer&apos;s disease, severe physical or mental disability); allergy to fuchsin dye, use of fixed orthodontic appliances; tooth whitening in progress; enamel or dentin dysplasias, or craniofacial malformations that make the procedures to be performed difficult	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-223s4bw	Evaluation of the Laser in Periodontal and Bone Healing in Diabetics	Not yet recruiting	Intervention	2024-01-30	<NULL>	<NULL>	6763	Evaluation of Photobiomodulation in Periodontal and Bone Repair in Diabetic Patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-223s4bw	<NULL>	"Study 1: Participants will be selected according to the following
inclusion criteria: 18 years old, positive diagnosis for Grade B or C periodontal disease, stages 2-4; presence of at least 16 teeth in the oral cavity, with at least 4 non-neighboring sites with a probing depth of 5 mm and bleeding, absence of periodontal treatment one year before the research and not having used antibiotics in the last three months . Study 2: During study 1, patients who consent to participate in study 2 must present the following characteristics: Individuals over 18 years of age; individuals with teeth condemned due to lack of periodontal support; individuals who are indicated for future rehabilitation with an implant (in the region of the units to be extracted); individuals with ASA I or II classification; individuals with the cognitive capacity to maintain their own oral hygiene.”"	"&quot;Study 1: The following will be excluded from the study: pregnant or lactating women, who have periodontal treatment in less than a year, who have used antibiotics in the last three
months, patients using antiresorptive medications.Study 2: The following will be excluded from this study: patients who are metabolically decompensated (ASA classification equal to or greater than III - except diabetics); chronic users of antiresorptive and immunosuppressive medications; patients who present acute periodontitis; heavy smokers (more than 10 cigarettes per day); pregnant and breastfeeding women; history of radiotherapy to the head and neck; have a diagnosis of bruxism; immunosuppressed; teeth with root dilaceration or condition that requires odontosection.”"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-10npxkxm	Effects of Kettlebell Workout and Detraining on Cardiorespiratory Capacity of Young Women	Terminated	Intervention	2024-01-29	<NULL>	<NULL>	6749	Effects of Kettlebell Training and Detraining on Cardiorespiratory Fitness in young women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-07	Universidade Federal do Espirito Santo	Universidade Federal do Espirito Santo	https://ensaiosclinicos.gov.br/rg/RBR-10npxkxm	<NULL>	being female; be between 18 and 30 years old; not having previous experience with the practice of kettlebell; present suitable physical conditions for tests and training (under the assessment of a cardiologist); score between “sedentary” and “irregularly active (A or B)” on the International Physical Activity Questionnaire (IPAQ); present cardiorespiratory fitness between “very poor” and “fair”, according to the classification of the American Heart Association (AHA) by VO2max (ml.kg-1.min-1).	Hypertensive subjects; smokers; subjects using medication, ergogenic or nutritional supplements known to affect metabolism or exercise performance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-7v374c6	Simulation-based nursing process: learning and translation to clinical practice	Recruitment completed	Intervention	2024-01-29	<NULL>	<NULL>	6750	The effectiveness of simulation based on the nursing process on learning, clinical judgment and anxiety and its translation into clinical practice in nursing students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-17	Faculdade de Enfermagem da Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7v374c6	<NULL>	Be an undergraduate nursing student; Be enrolled in the Pediatric and Neonatological Nursing II discipline	Absence on the day of the intervention; Not correctly filling out the data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-5tbdpy5	Effect of Mechanical Ventilation Pressure Changes in Obese patients undergoing Laparoscopic Surgery	Not yet recruiting	Intervention	2024-01-29	<NULL>	<NULL>	6751	Effect of ventilatory strategy with Recruitment Maneuvers and PEEP Titration versus ventilatory strategy with Recruitment Maneuvers and 6 cmH2O PEEP versus ventilatory strategy without Recruitment Maneuvers and 6 cmH2O PEEP in Obese patients submitted to Videolaparoscopic Bariatric Surgery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Saullo Queiroz Silveira	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5tbdpy5	<NULL>	"Individuals aged 18 to 65 years old; American Society of Anesthesiologists Physical Status Classification System 2 or 3;
Body mass index ≥ 30 Kg/m2; Elective laparoscopic bariatric surgery; Elective robotic bariatric surgery"	American Society of Anesthesiologists Physical Status Classification System greater than or equal to 4; congestive heart failure; kidney failure; alcohol or drug abuse; allergy to study components; patients undergoing degastrectomy; patients undergoing combined surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-2ntbth9	Assessment of response to antacids in children with Eosinophilic Esophagitis	Recruitment completed	Intervention	2024-01-29	<NULL>	<NULL>	6752	Evaluation of response to proton pump inhibitors in pediatric patients with Eosinophilic Esophagitis	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2021-05-01	Hospital Santa Casa de Misericórdia de Porto Alegre	Hospital Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2ntbth9	<NULL>	"Children and Adolescents aged 1month to 18 years who were referred to the pediatric endoscopy unit were included. Patients were included when they met the diagnosis criteria for Eosinophilic esophagitis (presenting at least one symptom of esophageal dysfunction; esophageal biopsy with more than 15 eosinophil per high power field) and absence of gastric and duodenal eosinophilia. 4 to 6 biopsies were randomly obtained from the
distal and middle esophagus. Biopsies specimens were also obtained from the antrum and duodenum to exclude gastritis and eosinophilic gastroenteritis"	Children were excluded if they had received prior and recent (up to 1 month before the endoscopy) treatment with proton pump inhibitor; corticosteroids or elimination diet; or if they presented duodenal or gastric eosinophilia or viral, fungal or caustic esophagitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-23rhfp8	The effect of Laser Acupuncture and Lasertherapy on women with Breast Pain	Recruiting	Intervention	2024-01-29	<NULL>	<NULL>	6753	Effectiveness of Laser Acupuncture and Laser Therapy in lactating women with Breast Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-23	Universidade Federal da Paraíba - Programa de Pós-graduação em Saúde Coletiva	Instituto Candida Vargas	https://ensaiosclinicos.gov.br/rg/RBR-23rhfp8	<NULL>	Women with breast pain. Older than 18 years. In Exclusive Breastfeeding (EBF) or mixed. Express a desire to continue breastfeeding. Being in rooming-in with babies born at term (over 37 weeks). Breastfeeding within one month of postpartum	Prolonged hospitalization of the mother or baby. Low birth weight or premature baby. Contraindication to breastfeeding. She has already stopped breastfeeding. Woman with previous mammoplasty. Woman with breast implants. Babies with facial malformations (cleft lip and cleft palate)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-6gs4bdh	Clinical study of the use of electrical stimulation on leg circulation and coagulation	Data analysis completed	Intervention	2024-01-29	<NULL>	<NULL>	6754	Study of the application of neuromuscular electrical stimulation on lower limb hemodynamics and systemic fibrinolytic activity	<NULL>	2-3, single-arm-study, single-blind	2-3	<NULL>	<NULL>	<NULL>	2019-11-06	Departamento de Cirurgia e Ortopedia da Faculdade de Medicina de Botucatu	Departamento de Cirurgia e Ortopedia da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6gs4bdh	<NULL>	Being between 18 and 40 years old. Both genders. Sign the Free and Informed Consent Form.  Have a Body Mass Index (BMI) between 18 and 34 kg/m2	Use of illicit drugs in the last 12 months. Use of the following medications in the last 24 hours: medicines for headache with vascular effect, such as sumatriptan, ergot derivatives, isomeptene, etc, analgesics such as dipyrone and paracetamol, non-steroidal anti-inflammatory drugs such as ibuprofen, naproxen, diclofenac, etc.  Consumption of foods in the last 24 hours with a known effect on vascular reactivity, according to the list: coffee, folic acid, vitamin C, high doses of fish oil, vitamin supplements, fruits and vegetables in large quantities such as cranberries (also known as cranberries) and grapefruit (also known as grapefruit), beets and black currants, wine, tea, cocoa and derivatives, chocolate and hazelnuts, natural grape and orange juice, cheese, probiotics (foods with this effect), capsaicin, like pepper, energy drinks, beer. Any significant illness within the last 4 weeks of exposure. Pregnancy or lactation. Use of hormonal contraceptive method, including IUD etc., in the last 3 months. Active smoker or ex-smoker in the last 12 months. History of peripheral arterial obstructive disease. Ankle-brachial index less than 0.9, defined in anamnesis and physical examination. History of chronic venous insufficiency in the lower limbs. Ulcer on lower limbs. History of venous thromboembolism. History of fracture or presence of metallic implants in lower limbs. Have an infection at the electrode implantation site. Have participated in a drug or medical device study up to 4 weeks previously. Use of any neuro-modulating device. Surgery 3 months before the study (such as abdominal, gynecological, etc.). Trauma to the lower limbs that may prevent correct electrical stimulation of the common peroneal nerve. Use of a pacemaker or implantable cardioverter-defibrillator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-7tdjcn5	How safe is the use of Botulinum Toxin type A in the treatment of Masseter Hypertrophy?	Recruitment completed	Intervention	2024-01-24	<NULL>	<NULL>	6746	Efficacy and safety of using Botulinum Toxin type A in the Masseter Hypertrophy treatment	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-17	Faculdade Ingá - UNINGÁ/Paraná	Associação Brasileira de Odontologia- Secção Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7tdjcn5	<NULL>	Female patients; age between 25 and 50 years; complaining of enlargement of the lower third of the face; complaining of unilateral or bilateral hypertrophy of the masseter muscle; have not received aesthetic procedures on the lower third of the face in the last 12 months	Having received an anti-tetanus or COVID-19 vaccine within a period of less than three months, before starting the research; having previously received injections of botulinum toxin for aesthetic or therapeutic purposes; presenting autoimmune diseases; pregnant and lactating women; present neuromuscular diseases (Myasthenia gravis and Lambert-Eaton Syndrome); in current use of drugs that act on neuromuscular junctions; having performed cosmetic surgeries on the lower third of the face; missing teeth; individuals under 25 years of age; those who do not agree to sign the Free and Informed Consent Form; those who receive some type of vaccine during the research; received aesthetic procedures in the lower third of the face in the last 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-10jn7f39	Oral ketotifen associated with oral tranexamic acid for the treatment of facial melasma in women	Recruitment completed	Intervention	2024-01-23	<NULL>	<NULL>	6744	Oral ketotifen associated with oral tranexamic acid for the treatment of facial melasma in women: a randomized, double-blind, placebo-controlled trial	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de São Paulo - UNIFESP	Universidade Federal de São Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-10jn7f39	<NULL>	Adult women aged 18 to 65 will be included, with a clinical diagnosis of facial melasma without previous treatment, except for the use of sunscreen, for at least one month.	Participants with other facial dermatoses, pregnant or lactating women and immunosuppressed women will not be included. Women at risk for thromboembolism: using contraceptives or hormone replacement therapy, smokers, obese, sedentary or with a personal or family history of thrombosis will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-7bct4vc	Efficacy of whitening toothpaste in the treatment of darkened teeth	Recruiting	Intervention	2024-01-23	<NULL>	<NULL>	6745	"Efficacy of a 3% hydrogen peroxide dentifrice  in
tooth color change: multicenter randomized clinical trial"	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade federal da paraíba	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7bct4vc	<NULL>	Volunteers recruited in the municipalities of João Pessoa/PB and Ponta Grossa/PR; healthy volunteers; both genders; non smokers; minimum age of 20 years and maximum age of 59 years; good oral health; teeth free from carious lesions; gingival recessions and active periodontal disease in the anterior region; canines color A2 or darker according to the Vita Classical scale	Previous tooth bleaching; previous tooth sensitivity; presence of dental prosthesis; presence of orthodontic appliance; restorations in upper anterior teeth; non-carious cervical lesions; endodontic treatment in upper anterior teeth; teeth with tetracycline staining or fluorosis; visible cracks in the teeth; pregnant or breastfeeding women; habit holders parafunctional	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-104b9shm	Use of the muscle relaxant Rocuronium in abdominal surgeries by video: comparison between small fractioned doses and continuous infusion	Not yet recruiting	Intervention	2024-01-22	<NULL>	<NULL>	6741	Use of Rocuronium in elective Videolaparoscopic surgeries: comparison between bolus administration and continuous infusion	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Hospital Central do Exército	Hospital Central do Exército	https://ensaiosclinicos.gov.br/rg/RBR-104b9shm	<NULL>	Adults over 18 years old; both sexes; ASA I, II and III - Anesthetic risk classification according to the American Society of Anesthesiologists [ASA1 (patient without comorbidities), ASA 2 ( patient with compensated comorbidities, without functional limitations), ASA 3   (patient with decompensated comorbidities with mild functional limitation.)]; surgery expected to last more than 1 hour	Known allergy to Rocuronium and/or Sugammadex; prior extensive surgery in the surgery cavity; locomotor or neurological disease; gestation; kidney or liver failure; refusal by the patient or his guardian; concomitant use of drugs that are known to interact with Rocuronium according to the manufacturer&apos;s package leaflet	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-9m5psj7	The Effects caused by Stimuli on the skin on Body Functions	Recruitment completed	Intervention	2024-01-22	<NULL>	<NULL>	6742	Effects of Different Tissue Stimuli on Functional Behavior and Motor Action	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Pitágoras UNOPAR Anhanguera	Universidade Pitágoras UNOPAR Anhanguera	https://ensaiosclinicos.gov.br/rg/RBR-9m5psj7	<NULL>	Participants of both sexes; aged between 18 and 35 years; practitioners of physical activity; adults with and without low back pain; practitioners of physical activity or amateur/professional athlete at least 3 to 5 times a week; volunteers with and without chronic low back pain, being active workers in the job market; women with mild, moderate and severe scores on the Cellulite Severity Scale; volunteers with and without chronic low back pain	Have any type of highly serious neurological, cardiorespiratory, skin metabolic and/or orthopedic disease; vestibulopathies and labyrinthine crises; mental problem, attention and speech disorders; some other type of force majeure problem that interfered with physical and functional tests; having undergone some type of surgery on the locomotor system; having undergone a surgical procedure on the ankles or feet; have an allergy to bandages; physiotherapeutic treatment; use of analgesics, anti-inflammatories or muscle relaxants in the last week; not volunteer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-2yyd8jb	Effect of Caffeine or Transcranial Direct Current Stimulation on attack decision-making in trained beach volleyball players after prolonged cognitive effort by use of social media: a study crossover randomized	Recruitment completed	Intervention	2024-01-22	<NULL>	<NULL>	6757	Caffeine and Transcranial Direct Current Stimulation: effect on the performance of mentally fatigued young athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Yago Pessoa da Costa	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2yyd8jb	<NULL>	Training beach volleyball for at least two years; compete on the regional circuit; have competed in the previous year on the national circuit; be at least 22 years old; male	Withdraw from the research for any reason; sustain an injury during the research; fail to comply with recommended procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-2tq2jky	Multicomponent exercises in older adults - VIVIFRAIL®	Not yet recruiting	Intervention	2024-01-22	<NULL>	<NULL>	6878	Effect of multicomponent exercises on the intrinsic functional capacity of older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-25	Pontifícia Universidade Católica do Rio Grande do Sul	Fundação de Assistência Social e Cidadania- FASC	https://ensaiosclinicos.gov.br/rg/RBR-2tq2jky	<NULL>	Older individuals of both genders; aged at least 60; who regularly attend meetings of elderly groups at the Foundation of Social Assistance and Citizenship; who do not have severe visual, auditory, or cognitive impairment that would hinder the safe completion of the proposed assessments or exercises	Participants who have surgeries or scheduled procedures in the next eight months that would prevent them from participating in the exercise program; participants who cannot remain seated without support for at least 10 minutes during the functional assessment; participants who, during the cognitive assessment, demonstrate an inability to respond to verbal commands; exclusion criteria for the VIVIFRAIL® exercise protocol: Acute myocardial infarction or recent unstable angina within 6 months; recent report of uncontrolled atrial or ventricular arrhythmias within 30 days; history of dissecting aortic aneurysm; severe aortic stenosis; acute endocarditis/pericarditis; uncontrolled high blood pressure; acute thromboembolic disease; severe acute heart failure; severe acute respiratory failure; uncontrolled orthostatic hypotension; acute decompensation of diabetes mellitus or uncontrolled hypoglycemia; recent fracture within the last month; any other circumstance that is considered a hindrance or risk for engaging in physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:59
RBR-4t7wq67	Red light therapy to control bacteria adhered to orthodontic devices	Recruitment completed	Intervention	2024-01-20	<NULL>	<NULL>	6740	Photodynamic therapy to control biofilm adhered to orthodontic brackets	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-23	Fundação Hermínio Ometto	Faculdade de integração do sertão - FIS	https://ensaiosclinicos.gov.br/rg/RBR-4t7wq67	<NULL>	Volunteers must present the 4 upper premolars intact, without restoration or abnormalities involving the buccal surface.	Those who are using antibiotics, who do not follow oral hygiene instructions, who are hypersensitive to dyes, pregnant women, smokers, who are undergoing previous orthodontic treatment, who have periodontal disease, calculus, cavities in selected teeth, the presence of orthodontic appliances and /or fixed retention and the presence of occlusal changes such as: crowding, rotation, extrusion or intrusion of the selected teeth will be excluded from the sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-7hmq4rp	Effect of Virtual Reality in the context of medical teaching in cardiology	Recruitment completed	Intervention	2024-01-18	<NULL>	<NULL>	6738	Effect of Virtual Reality on self-confidence, motivation and acquisition of clinical skills in medical students in the context of teaching topics in cardiology	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-26	Escola Multicampi de Ciências Médicas da Universidade Federal do Rio Grande do Norte	Escola Multicampi de Ciências Médicas da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7hmq4rp	<NULL>	Undergraduate medical students at the Escola Multicampi de Ciências Médicas (EMCM) regularly enrolled in the ‘Dyspnea, Chest Pain and Edema’ module; have at least 75% attendance during the training offered; students who complete all research instruments; of both genders	Students whose data collection instruments contain partial or illegible informatio; scientific initiation scholarship holders linked to the researcher; and collaborators who contributed to the execution of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-3qqbykm	Efficacy of the face-to-face STEP protocol compared to the remote one in infants at risk of developmental delay	Recruiting	Intervention	2024-01-17	<NULL>	<NULL>	6734	Efficacy of the face-to-face STEP protocol compared to the remote one in infants at risk of developmental delay: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal de São Carlos - UFSCAR	Universidade Federal de São Carlos - UFSCAR	https://ensaiosclinicos.gov.br/rg/RBR-3qqbykm	<NULL>	Infants aged between 3 and 9 months corrected age. Of both sexes. At biological risk - to be considered at risk, the infant must present at least one of the following factors: prematurity (&lt;33 weeks of gestational age), low weight (below the 10th percentile according to gestational age and sex), asphyxia (Apgar score from 0 to 3 for more than 5 minutes, and/or neurological manifestations in the neonate such as seizures, coma or hypotonia, need for cardiorespiratory resuscitation or use of oxygen therapy, hospitalization in the Intensive Care Unit, General Movement Assessment (GMA) altered (absence of fidgety or abnormal fidgety), total score on the Hammersmith Neurological Examination (HINE), below 60 at three months, below 70 at six months and equal to or less than 73 at infants aged between nine and 12 monthsonths	Infants with genetic abnormalities; infants who are in a hospital environment; who are blind or deaf; with a clinical diagnosis of respiratory diseases; with congenital diseases such as heart disease, kidney or ophthalmological alterations; physiologically unstable infants; infants whose primary caregivers have cognitive or motor disabilities that prevent the understanding or performance of activities administered at home or are unable to take the infant to clinics the required number of days a week; and/or do not sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-58fyp3m	Strength Training versus Strength Training with the Addition of Aerobic Exercise: Which Is the Better Approach in the Treatment of Non-Specific Low Back Pain?	Recruiting	Intervention	2024-01-17	<NULL>	<NULL>	6736	Effectiveness of adding aerobic exercise to resistance exercise versus resistance exercise alone in improving pain intensity and functional disability in patients with chronic non-specific low back pain: A randomized, double-blind controlled clinical trial with 3-month follow-up	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-15	Faculdade de Fisioterapia e Terapia Ocupacional da Universidade Federal do Pará	Faculdade de Fisioterapia e Terapia Ocupacional da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-58fyp3m	<NULL>	Patients aged between 18 and 60; both genders; with non-specific lumbar spine pain (&gt;= 3 months) of at least 3 points on the 0-10 numerical pain scale	Presence of serious musculoskeletal; cardiovascular and metabolic disorders; a history of neurological injuries; obesity (Body Mass Index above 30 kg/m2); pregnancy; previous spinal surgery; any health condition that makes it impossible to exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-8z285wq	Effects of Immersive and Non- Immersive Virtual Reality Games on Anxiety and Cognition in Parkinson&apos;s Disease	Terminated	Intervention	2024-01-17	<NULL>	<NULL>	6737	Usability, applicability, and therapeutic potential of Different Virtual Reality Systems in patients with Neurological, Rheumatological, and Orthopedic Injuries	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Faculdade de Ceilândia - Universidade de Brasília-UnB	Faculdade de Ceilândia - Universidade de Brasília-UnB	https://ensaiosclinicos.gov.br/rg/RBR-8z285wq	<NULL>	The inclusion criteria were completed elementary education; a minimum score of 24 on the mini mental state examination;  a score below 7 on the Geriatric Depression Scale; a score between 1 and 3 on the Hoehn and Yahr Scale (mild/moderate); absence of auditory or visual deficits that would impair participation in the virtual reality training	The exclusion criteria were any clinical condition that would compromise the intervention; previous experience with gaming consoles and/or attending another specialized rehabilitation program during the training; history of motion sickness; dizziness; seizures; epilepsy; active nausea	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-7tkkqj4	Tomographic evaluation of Prosthesis-Guided  after Tooth Extraction	Recruitment completed	Intervention	2024-01-16	<NULL>	<NULL>	6731	Tomographic evaluation of the healing of Fresh Alveoli using the Prosthetically Guided Alveolar Reconstruction Technique: a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-05	Universidade Do Grande Rio-Unigranrio	Universidade Do Grande Rio-Unigranrio	https://ensaiosclinicos.gov.br/rg/RBR-7tkkqj4	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 60 years; indication of extraction of at least one tooth; gingival margin in harmony with the gingival margins of neighboring teeth; proximal bone crests of neighboring teeth compatible with normal periodontium.Total sample of 20 teeth	Smoking volunteers; diagnoses of hematological or metabolic pathologies; use of bisphosphonates or any medication that interferes with bone healing; diseases that compromise the immune system; patients undergoing radiotherapy in the head and neck region; pregnant or lactating women; untreated periodontal disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-66pb66j	Evaluation of an intervention to promote leadership coaching in nurses	Terminated	Intervention	2024-01-16	<NULL>	<NULL>	6732	Assessment of the feasibility of an intervention to promote the exercise of coaching leadership in nurses: a pilot study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-10-27	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-66pb66j	<NULL>	"Nurses: professionals who provided direct support to patients, who did not have training in coaching or who had not previously undergone a coaching process and with three months of experience in the institution.
Nursing technicians: professionals under the supervision of the nurses who received the intervention, and who had three months of experience in the institution."	"Nurses: participants who did not attend two intervention sessions or who did not respond to the instruments in the last stage of this phase of the study.
Nursing technicians: participants who initially agreed to participate, but who, for any reason, withdrew from the research and did not respond to the instruments, in the last stage of this phase of the study."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-3stzx6f	Consumption of Interesterified Fat and its action on the Metabolism of healthy adults	Recruiting	Observational	2024-01-16	<NULL>	<NULL>	6733	Estimated dietary intake of Interesterified Fat and its relationship with Metabolic Changes in a sample of adults	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-09	Fundo de apoio ao ensino, pesquisa e extensão da Universidade Estadual de Campinas (FAEPEX/UNICAMP)	Fundo de apoio ao ensino, pesquisa e extensão da Universidade Estadual de Campinas (FAEPEX/UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-3stzx6f	<NULL>	Individuals with the cognitive capacity to understand the study procedures and sign the Free and Informed Consent Form (TCLE), of both sexes, aged between 20 and 59 years old, and with a body mass index (BMI) of 20, will be considered eligible 20 kg/m² to 29.9 kg/m².	Individuals with catabolic diseases or those that directly or indirectly affect food intake (kidney, liver, oncological, intestinal inflammatory diseases, genetic syndromes and autoimmune and/or immunosuppressive diseases), individuals who have suffered a greater body weight change will be considered ineligible. than 5% in the last 6 months, pregnant women and nursing mothers and athletes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-3d3t8zd	Evaluation of the improvement of symptoms and of the vulva tissue in Lichen Sclerosus in patients with joint treatment of Anti-inflammatory Cream and the application of energy called Radiofrequency	Recruitment completed	Intervention	2024-01-15	<NULL>	<NULL>	6730	Evaluation of clinical and histopathological improvement of Vulvar Lichen Sclerosus in patients with combined treatment with Topical Corticosteroids and Fractionated Microablative Radiofrequency	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-17	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-3d3t8zd	<NULL>	Histopathological diagnosis of vulvar lichen sclerosus being treated with corticosteroids.	HIV positive women, malignant neoplasms, pregnant women, use of systemic immunosuppressants, no desire to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-9kqwd5f	Response of aquatic exercises on mental health, functional autonomy and muscular efficiency in comorbid elderly subjects	Recruitment completed	Intervention	2024-01-14	<NULL>	<NULL>	6725	Aquatic exercises and mental health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade do Extremo Sul Catarinense - UNESC	Universidade do Extremo Sul Catarinense - UNESC	https://ensaiosclinicos.gov.br/rg/RBR-9kqwd5f	<NULL>	Being over 60 years of age; both genders; presenting a medical certificate with the three comorbidities (hypertension, (hypertension, diabetes and depression) associated; presenting a medical certificate with authorization to practice aquatic physical exercise; bringing a copy of their vaccination card with all 3 doses of COVID-19 completed	Having a medical impediment to physical exercise certified by a doctor; having oother type of pathology associated or not that may interfere with the research results; do not present the requested documents; not be over 60 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-8462fhs	Dry Needling and temporomandibular dysfunction	Data analysis completed	Intervention	2024-01-14	<NULL>	<NULL>	6726	Evaluation of the effects of Dry Needling and Manual Therapy on pain in patients with Temporomandibular Disorder and its relationship with fear of Covid-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-04	Universidade Federal de Lavras	Universidade Federal de Lavras	https://ensaiosclinicos.gov.br/rg/RBR-8462fhs	<NULL>	Adults between 18 and 40 years old; both genders; diagnosed with Temporomandibular Disorders (TMD)	People under 18 and over 40; people undergoing orofacial treatment; people using psychotropic medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-8hdfjdn	Effects of Meditation on sleep quality of medical students	Recruiting	Intervention	2024-01-14	<NULL>	<NULL>	6727	Effects of a Meditation Program on the sleep quality of medicine course students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-8hdfjdn	<NULL>	"Interest in participating in the study; age between 18 and 59 years old; both genders; being duly registered in the
Medicine course at Passo Fundo faculties, from the 1st to 12th phase of the course"	Have participated in another course or workshop on meditation in the last 4 weeks in addition to the invitation to study;  being an active practitioner of meditation, yoga, tai-chi, qui-gong (at least 6 months before the start of the study); previous medical diagnosis of cognitive, language or communication deficits; alcohol dependence and other chemical substances; previous medical diagnosis of a disorder with risk of suicide or attempt of previous suicide; previous medical diagnosis of post-traumatic stress disorder; previous medical diagnosis of  depressive disorder currently untreated; previous medical diagnosis of schizophrenia or delusional/hallucinatory disorders; revious medical diagnosis of social anxiety (difficulty being in a classroom)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-4ysjz3b	Temporomandibular Joint disc position and shape in patients submitted to two protocols of Rapid Maxillary Expansion and Facemask therapy	Recruitment completed	Intervention	2024-01-14	<NULL>	<NULL>	6728	Evaluation of the Temporomandibular Joints using Magnetic Resonance Imaging in patients with Class III and/or Subdivision Malocclusion, treated with two different Extrabuccal Jaw Expansion and Traction protocols	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-11-01	Universidade Federal de São Paulo	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-4ysjz3b	<NULL>	Children and adolescents with anteroposterior discrepancy between the maxilla and mandible, caused by maxillary retrusion, mandibular protrusion and/or a combination of both, clinically assessed by facial analysis (nasolabial angle, chin-neck line and angle);children and adolescents with Class III and/or Class III Angle subdivision malocclusion;and children and adolescents with mixed dentition or beginning permanent dentition	Children and adolescents with decayed and periodontally compromised teeth; those who had undergone previous orthodontic treatment; those with a metal device; those who were claustrophobic and/or anxious, making it impossible to perform the MRI scan	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-82wt6jr	The effect of auriculotherapy in the treatment of pain symptoms, bite force and brain activity in people with changes in the temporomandibular joint	Not yet recruiting	Intervention	2024-01-12	<NULL>	<NULL>	6721	Efect of auriculotherapy by laser biophotomodulation in clinical symptoms, bite force and cortical electrical activity and muscle in people with temporomandibular dysfunction:Crossover randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-30	Universidade Federal Alfenas	Universidade Federal Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-82wt6jr	<NULL>	Both sexes; age above 18 years; diagnosis of temporomandibular disorder	use of ear piercing or birthmark; history of neoplasm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-10ksfmxx	Analysis of strategies for Dental Sensitivity reduction: a medical study	Not yet recruiting	Intervention	2024-01-12	<NULL>	<NULL>	6722	Effects of Glutaraldehyde/HEMA-based products, S-PRG or 980nm Diode Laser on the Dentin Hypersensitivity treatment: a randomized controlled clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10ksfmxx	<NULL>	Participants who have at least one tooth with dentin hypersensitivity, with a score equal to or greater than 4 on the Analogic Visual Scale (VAS). Participants must be aged between 18 and 65. Both genders. Having overall good health. Being available to attend the scheduled appointments and treatment sessions throughout the study period	Individuals with active caries lesions and/or defective restorations on the selected and/or adjacent teeth; structural dentin loss requiring restoration or periodontal treatment; prior use of professional desensitizing agents in the last 6 months; smokers; pregnant individuals; those using anti-inflammatory and/or analgesic medications during the study period - or up to 72 hours before the initial assessment; those who regularly use anticonvulsants, antihistamines, sedatives, and/or anxiolytics; have orthodontic appliances; have a history of or current presence of neoplasms in the head and neck region; or are allergic to any component of the products used in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-7zz3b6p	Qualitative somatosensory clinical evaluation of recipient and donor sites of subepithelial connective tissue Grafts	Data analysis completed	Intervention	2024-01-12	<NULL>	<NULL>	6723	Somatosensory profile in recipient areas of connective tissue Graft and donor palate: retrospective qualitative sensory evaluation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7zz3b6p	<NULL>	Patients of both genders; age between 18 - 70 years; normal and healthy palatal area; multiple gingival recessions (RT1) with at least one gingival recession ≥ 2 mm, including canines and premolars; systemically healthy patients with no contraindication to periodontal surgical procedures	Patients with prostheses with palatal coverage; palatal areas previously submitted to graft removal; teeth Mobility; smokers; pregnant and lactating women; history of periodontal disease or recurrent abscess formation; previously root coverage surgical procedures; use of medications (anticonvulsants, antihypertensives, contraceptives, or immunosuppressants) or drugs that influence wound healing; and a low level of oral hygiene (plaque index and bleeding index &gt;20%)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-5c23n4p	Evaluation of transcutaneous electrical nerve stimulation in patients with cancer pain under palliative care who make chronic use of morphine	Not yet recruiting	Intervention	2024-01-12	<NULL>	<NULL>	6724	Evaluation of low and high frequency transcutaneous electrical nerve stimulation in patients with cancer pain under palliative care who make chronic use of morphine: experimental study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-30	Fundação Pio XII - Hospital de Amor de Barretos	Fundação Pio XII - Hospital de Amor de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-5c23n4p	<NULL>	Patients at least 18 years old; of both sexes; who have neuropathic cancer pain assessed by the Questionnaire for the Diagnosis of Neuropathic Pain (DN-4), Nociceptive or Mixed, with pain intensity classified by Scale Visual Numerical greater than or equal to 4; who make chronic use of morphine, characterized as use more than three months ago	Patients who present inability to communicate verbal or cognitive inability to perform Transcutaneous Electrical Nerve Stimulation (TENS) and non-tolerance within the time proposed therapy; patients with cardiac conditions such as cardiac pacemakers and cardiac arrhythmias; metallic implants at the site of electrode placement;  epilepsy; dermatologic conditions, or skin lesions at the location of the pain that makes it impossible to attach the electrode and history of allergies to conductive gel componentes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-33sd66h	The effect of Reac treatment compared to placebo on the balance of individuals affected by stroke	Recruiting	Intervention	2024-01-11	<NULL>	<NULL>	6720	Effectiveness of Radio Electric Asymmetric Conveyer (Reac) neuromodulation treatment compared to placedo in the balance of individuals after Stroke: a randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-11-16	Asmed Latino America Comércio e Importação de Produtos Médicos Ltda	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-33sd66h	<NULL>	"Diagnosis of right or left hemispheric stroke of ischemic or hemorrhagic origin. Physiotherapeutic diagnosis of right or left hemiparesis due to stroke. Chronic cerebrovascular injury (injury time greater than 6 months). Absence of obvious orthopedic or neurological disorders not resulting from the stroke that could interfere with balance. Absence of rheumatic disorders with joint involvement of the lower limbs.
Have not participated in other clinical trials related to the use of transcranial stimulation within one month. Use of medications that may interfere with the assessment of study efficacy, such as opioids, barbiturates, benzodiazepines and antipsychotics. Ability to understand and execute simple verbal commands. Ability to remain upright for at least 60 seconds without the need for human support or an assistive device. Ability to walk without human assistance, being allowed to use an auxiliary device"	Failing to complete assessments of outcome measures before and after REAC treatment with NPO (neurpostural optimization) protocol. Instability of vital signs at the time of study procedures. Report of dizziness at the time of the data collection procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-45vq9cb	Durability of toothbrushes in orthodontic patients: a randomized clinical trial	Not yet recruiting	Intervention	2024-01-10	<NULL>	<NULL>	6717	Durability and efficiency of orthodontic toothbrushes in patients with fixed appliances: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-04	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-45vq9cb	<NULL>	Patients in the permanent dentition phase; between 13 and 50 years old; with upper and lower fixed braces; bonded or banded from molar to molar; of both sexes; in good health and with a minimum of 20 permanent teeth, excluding third molars	Patients with active caries; patients with dental development defects; pregnant women; patients with systemic diseases (diabetics or smokers); patients using medications that may affect gingival health (such as calcium channel blockers; cyclosporine and anticoagulants) will be previously excluded; individuals allergic to the plaque discloser and who have limited manual dexterity and cognitive difficulties; cleft lip and palate; syndromes and/or craniofacial anomalies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-10wpdd9c	Effect of a lifestyle change program for the treatment of Obesity with online and in person support	Recruitment completed	Intervention	2024-01-10	<NULL>	<NULL>	6718	Effect of a hybrid program of intensive lifestyle change in the treatment of Obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Hospital das Clínicas da Faculdade de Medicina de São Paulo	Hospital das Clínicas da Faculdade de Medicina de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10wpdd9c	<NULL>	Minimum age of 18 years; body mass index (BMI) equal to or greater than 30; have a smartphone with internet access	patients not adhering to the project proposal; undergoing bariatric surgeries; pregnant women; breastfeeding women; illiterate individuals; people with endocrine diseases; genetic syndromes that cause obesity; cognitive deficit; uncontrolled psychiatric illness	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-5vtrng9	Clinical efficacy of Viscoflex® Viscosupplements	Terminated	Intervention	2024-01-10	<NULL>	<NULL>	7779	Single-blind study of clinical efficacy, perceived efficacy, and tolerability of Viscoflex®	<NULL>	1, single-arm-study, single-blind	1	<NULL>	<NULL>	<NULL>	2023-10-15	Vênus Medicina Física e Reabilitação S/C Ltda	Vênus Medicina Física e Reabilitação S/C Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5vtrng9	<NULL>	Age group from 40 to 59 years old (during the pandemic and not belonging to the risk group – see exclusion criteria); male and female genders; Fitzpatrick skin type: I to V; participants with osteoarthritis (knee, shoulder, trapezius regions, and metacarpal);intact skin in the test area	Skin disorders in the region of product application (joints);pregnant or breastfeeding women;history of hypersensitivity to hyaluronic acid;Immunodeficiency;tendency to form hypertrophic or keloid scars;continuous use of anticoagulants or acetyl salicylic acid;use of surfactants containing quaternary ammonium salts in dermatological preparations;venous or lymphatic stasis in the limb to be treated;signs of inflammation and/or infection in the joint to be treated;persons in any of the COVID-19 risk groups, that is, over 60, with diabetes, chronic cardiovascular, kidney or respiratory disorders, immunosuppressed or bearing any other conditions that the medical doctor deems as belonging to a risk group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-4995qng	Breathing Exercises in Healthy Children	Data analysis completed	Intervention	2024-01-09	<NULL>	<NULL>	6713	Expiratory Muscle Training in Healthy Children: Randomized Clinical Trial	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2022-08-12	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4995qng	<NULL>	Healthy subjects, aged between 3 and 12 years old, who do not have comorbidities, will be included in the study.	Subjects with any type of comorbidity and who are younger than 2 years and 11 months or older than 12 years and one month will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-62cftbp	Efficacy of BoNT-A treatment in patients with Awake Bruxism and Temporomandibular Disorder (TMD)	Recruitment completed	Intervention	2024-01-09	<NULL>	<NULL>	6714	Awake Bruxism Diagnosis and Treatment - Randomized Controlled Trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-03-20	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-62cftbp	<NULL>	Volunteers of both genders; aged between 18 and 60 years; with Temporomandiibular Disorders; With high frequency of awake bruxism activity	Volunteers with facial and Temporomanbular Joint trauma; using full dentures or removable partial dentures; ongoing orthodontic treatment; blood dyscrasia patients; with presence of arthritis; arthrosis; diabetes; neurological pathologies; fibromyalgia; who received tetanus vaccine or botulinum toxin injections in the three months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-69pjrtt	Utilization of Clinical Simulation for educating nurses about the Sexuality of the Elderly	Not yet recruiting	Intervention	2024-01-09	<NULL>	<NULL>	6715	Competencies for Addressing Elderly Sexuality: A Simulated Intervention proposal	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-69pjrtt	<NULL>	Nurses working in Primary Health Care	Nurses  who are absent from any stage of the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-22j8728	Evaluation of the effectiveness of galvanic vestibular stimulation in the rehabilitation of Parkinson&apos;s Disease	Recruiting	Intervention	2024-01-09	<NULL>	<NULL>	6716	Evaluation of the use of Galvanic Vestibular Stimulation in the Treatment of Postural Instability and cognitive improvement in Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-07-30	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-22j8728	<NULL>	Patients with Parkinson&apos;s disease or syndrome; Diagnosis of postural instability based on neurological examination: score greater than or equal to 1 in part III (motor assessment) item 12 (postural stability) of the Movement Disorders Society scale – UNIFIED PARKINSON’S DISEASE RATING SCALE; Time greater than 10 seconds when performing the walking test Timed up and go test ; Score less than or equal to 49 points on the Berg Balance Scale; No medication changes for Parkinson&apos;s treatment in the last 30 days; Tests must be carried out with the patient under the influence of medication – ON state	History of previously diagnosed vestibular disease; Individuals who had a history of myelitis or stroke; Patients with immobility syndrome (use of a wheelchair or walking aid device); Patients with a pacemaker or any device that may undergo changes resulting from the use of Galvanic Vestibular Stimulation; Cognitive changes justified by some other pathology associated with Parkinson&apos;s disease; Individuals alienated and unable to answer for their own actions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-89fbts7	Cognitive Stimulation Therapy for Neurocognitive Disorders in Brazilian Long-Term Care Institutions for the Aged	Recruiting	Intervention	2024-01-09	<NULL>	<NULL>	7830	Implementation of Cognitive Stimulation Therapy for Neurocognitive Disorders in Brazilian Long-Term Care Institutions	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-15	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-89fbts7	<NULL>	Older adults living in Long Term Care Facilities for the aged; with mild dementia; or with mild neurocognitive disorder; aged at least 60 years; both sexes	Communication disabilities; moderate to severe dementia; other severe decompensated mental disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-7gw699m	Effects of Pilates on Chronic Low Back Pain in employees at a private university	Recruitment completed	Intervention	2024-01-08	<NULL>	<NULL>	6709	Effects of the Pilates Method on Chronic Low Back Pain in employees at a private higher education institution – a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-28	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-7gw699m	<NULL>	Volunteers of both sexes; age between 18 and 50 years old; symptoms of low back pain persisting beyond the acute phase, defined as pain lasting more than 12 weeks or more; pain between 3 and 7 on the 10 cm visual analogue scale	Volunteers who have health problems (cardiovascular, neurological, musculoskeletal impairment or any contraindication to exercising); be carrying out regular training (weight training exercises in the gym, running and other types of training); self-reported functional changes in the lower and upper limbs that prevent the execution of exercises and tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-6xtvg5w	Effects of transcutaneous auricular vagus nerve stimulation in individuals with Parkinson&apos;s disease - a double-blind randomized controlled clinical trial	Recruiting	Intervention	2024-01-08	<NULL>	<NULL>	6711	Effects of non-invasive transcutaneous auricular vagus nerve electrical stimulation in individuals with Parkinson&apos;s disease - A double-blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-23	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6xtvg5w	<NULL>	Individuals of both sexes; aged between 40-80 years, with a diagnosis confirmed by a neurologist of Parkinson&apos;s disease present in stages 1 to 3 of the Hoehn and Yahr scale; who have motor and cognitive complaints related to the Unified Parkinson&apos;s Disease Rating Scale (UPDRS) and who have been on stable Parkinson Disease medication for at least 30 days	Individuals with characteristics of other types of parkinsonism; having other health conditions such as musculoskeletal problems, decompensated respiratory or cardiovascular problems, uncontrolled diabetes, uncontrolled systemic arterial hypertension, psychiatric conditions such as dementia diagnosed by a psychiatrist, contraindications for the intervention (implanted cardiac or cranial electronic medical devices, cochlear implant, pacemaker) or conditions in which the principal investigator assesses as not indicated for participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-3kzr42p	Effects of telerehabilitation on knee osteoarthritis	Recruiting	Intervention	2024-01-07	<NULL>	<NULL>	6707	Effects of two Telerehabilitation programs to improve the health status of people with knee Osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3kzr42p	<NULL>	Both sexes; over 40 years old and under 75 years old; clinical or radiographic diagnosis of knee osteoarthritis; symptomatic for at least 3 months; with internet access via smartphone, willingness to participate in the research and who sign the informed consent form (TCLE)	Arthroplasty or previous knee surgeries; another reason for the joint symptoms such as a tumor, inflammatory joint disease, or patellar tendinopathy; other symptoms more pronounced than osteoarthritis symptoms such as chronic widespread pain or fibromyalgia; cardiovascular, respiratory or neurological medical restrictions that make it impossible to participate in this study; inability to walk, go up and down stairs, sit down and stand up, cognitive impairment and who are undergoing physical therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-10rskkf5	Study of the effect of Low-Level Light Therapy on the salivary glands, proteomic analysis, quality of life and psychological aspects of individuals with Sjögren&apos;s Syndrome	Recruiting	Intervention	2024-01-07	<NULL>	<NULL>	6708	Study of the effect of photobiomodulation by Low-Level Light Therapy irradiation on the major salivary glands, proteomic analysis, quality of life and psychological aspects of individuals with Sjögren&apos;s Syndrome	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Odontologia de Bauru, Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10rskkf5	<NULL>	Individuals receiving dental treatment at the FOB-USP Stomatology clinic who complain of dry mouth not explained by disorders other than Sjogren&apos;s Syndrome, with any amount of unstimulated and stimulated salivary flow, over 18 years of age.	Individuals with dry mouth who have undergone head and neck irradiation or other disorders not associated with Sjogren&apos;s Syndrome and individuals currently taking secretagogues.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-8rvtccf	Pain and clinical characteristics following Crown Lengthening: study in smokers and non-smokers	Not yet recruiting	Intervention	2024-01-05	<NULL>	<NULL>	6704	Pain management and clinical characteristics after Gingival Surgery in smokers and non-smokers: randomized controlled trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-8rvtccf	<NULL>	Men and women aged at least 18 years; available to participate in all study phases; with a diagnosis of periodontal health in either intact or reduced periodontium; requiring ACC periodontal surgery with a need for osteotomy of at least 1 mm to restore supracrestal structures (periapical radiographs and/or transperiodontal probing will be used to determine the need for osteotomy in these patients); in the non-smoker group, only individuals who report never having smoked or having quit smoking for more than five years will be included; in the smoker group, only individuals who report daily consumption of at least ten cigarettes will be included	Individuals requiring crown lengthening for purely aesthetic purposes; those using any type of orthodontic appliance; individuals with soft or hard tissue tumors in the oral cavity; presence of active infectious foci (endodontic abscesses); chronic use of analgesics or anti-inflammatories for any condition, or use of any analgesics, anti-inflammatories, or chlorhexidine mouthwashes in the seven days preceding the periodontal surgery; this also includes pregnant or lactating; those who have received local or systemic antimicrobial treatment in the last 90 days; individuals requiring antimicrobial prophylaxis for dental treatment; individuals with a history of allergy to paracetamol, ibuprofen, or dipyrone, including their byproducts; a history of allergy to chlorhexidine, including its byproducts; patients with uncontrolled systemic diseases (such as diabetes); patients on anticoagulants or platelet anti-aggregants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-3jj783t	Durability of composite resin restorations in root canal treated teeth associated with an adjustable root canal post, fiberglass post or no post: randomized clinical trial	Recruiting	Intervention	2024-01-05	<NULL>	<NULL>	6705	Longevity of composite resin restorations in endodontically treated teeth associated with an adjustable post to the root canal, fiberglass post or without an intraradicular retainer: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-05	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3jj783t	<NULL>	Participants aged between 18 and 65 years old; both genders; with adequate oral health; who had endodontically treated teeth with 50% or less of coronal remaining	Patients who had teeth with root involvement such as fractures or cracks; mobility; poor oral hygiene; chronic or aggressive periodontitis; pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-8xk82pt	Study with Electrostimulation on the Skin of the Ankle Region in Children and Adolescents with Bladder Problems due to a Spine Problem	Not yet recruiting	Intervention	2024-01-05	<NULL>	<NULL>	6706	Transcutaneous Electrical Stimulation of the Posterior Tibial Nerve in Children and Adolescents with Neurogenic Overactive Bladder Secondary to Myelomeningocele: Randomized, Double-blind, Placebo-controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-02	UNiversidade Federal de Minas Gerais	UNiversidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8xk82pt	<NULL>	A sample will be provided for children and adolescents; aged between four and 18 years; diagnosed with refractory Hyperactive Neurogenic Bladder due to myelomeningocele using anticholinergics and a clean intermittent urinary catheter; patients whose parents or guardians agreed to participate in the study after reading, understanding and signing the Informed Consent Form; participants aged six years or over who decided to participate in the study, after reading, understanding and signing the Informed Consent Form.	Children and adolescents with neurogenic bladder due to other neurogenic causes such as spinal tumors, cerebral palsy, spinal cord trauma, among others; patients with underlying medical conditions (metabolic diseases, anorectal and urogenital malformations, previous urogenital surgery such as augmentation cystoplasty or vesicostomy); patients using a pacemaker; patients and/or parents or guardians who did not agree to participate in the study and/or did not agree with the Informed Consent Form and/or Informed Assent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-7p32sbb	Effects of different tonic, isometric, and isometric and vibratory Strength Training programs on Motor Symptomatology in People with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2024-01-03	<NULL>	<NULL>	6700	Effects of different tonic, isometric, and isometric and vibratory Strength Training programs on Motor Symptomatology in People with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-15	Universidad de las Americas	Universidad de Atacama	https://ensaiosclinicos.gov.br/rg/RBR-7p32sbb	<NULL>	Individuals of both sexes; diagnosis of Parkinson&apos;s disease in stages I-III according to the Hoehn and Yahr classification; authorized by your treating physician to participate in the intervention program; controlled medication; able to follow verbal instructions and with motor autonomy; mini - mental exam score greater than 23 points; Signed informed consent to participate in the study	Participants with adherence below 80% to the different types of intervention sessions will not be included in the results analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-9nm4zs9	Sex differences in post-exercise hypotension after a beach tennis session in middle-aged adults with hypertension: a randomized crossover clinical trial	Recruiting	Intervention	2024-01-03	<NULL>	<NULL>	6701	Effects of sports training with beach tennis on blood pressure in hypertensive individuals: a clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-25	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9nm4zs9	<NULL>	Men and women; Aged 35 to 65 years; medically diagnosed with hypertension; using up to two antihypertensive medications; willing to participate and sign the informed consent forms; office blood pressure between 130-179 and 80-110 mmHg	Diseases that limit the performance of physical exercises, such as lung disease, valvular heart disease, and renal failure; underlying cardiovascular disease previously diagnosed by a physician, occurring in the last 24 months, such as acute myocardial infarction, angina or stroke, or heart failure; diseases that reduce life expectancy; regular physical activity practitioners (i.e., 3 or more sessions per week of high intensity exercise moderate or vigorous); body mass index greater than 39.9 kg/m²; diabetic proliferative retinopathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-2mpn8qk	Coaching leadership development program for nurses	Not yet recruiting	Intervention	2024-01-03	<NULL>	<NULL>	6702	Effectiveness of a program for developing leadership coaching in nurses: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Hospital de Clínicas da UNICAMP	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2mpn8qk	<NULL>	Nurses; minimum age 18 years; both genders; provide direct assistance to the patient; work for at least three months at the institution; not have a temporary contract; not have undergone coaching training or have previously participated in a coaching process	Nurses who do not attend two sessions of the intervention program; professionals who do not respond to the instruments in T7; those who leave more than 50% of the questionnaire responses blank, at any time during the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-6jd7ps4	Results of Gum Treatment in exercisers and non-exercisers	Not yet recruiting	Intervention	2024-01-03	<NULL>	<NULL>	6703	Characterization of response to Periodontal Treatment of individuals practitioners and non-practitioners of physical exercise - a quasi-experiment	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6jd7ps4	<NULL>	Recreational CrossFit athletes who perform 3 to 5 workouts weekly; Professional Volleyball athletes; Sedentary patients at the Federal University of Paraná dental clinic; All participants must be systemically healthy and non-smokers, have a body mass index (BMI) of less than 30, and have periodontitis according to the 2018 Classification of Periodontal Diseases	People who have received periodontal treatment in the last 6 months; Present conditions that affect the research such as: diabetes, smoking, pregnant or lactating women; Use of antibiotics, anti-inflammatories, and immunosuppressants within 3 months prior to the study; Alcohol consumption; Use of drugs that can cause gingival hyperplasia; Recreational athletes who train with the main objective of competition performing more than 01 hour per day and exceeding 5 hours per week of training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-3f598cj	Safety and Immunogenicity of a Chimeric Recombinant Covid19 Vaccine SpiN-Tec MCTI UFMG	Recruiting	Intervention	2024-01-02	<NULL>	<NULL>	6696	Phase 1/2, double-blind, randomized, active-controlled first-in-human clinical trial to evaluate the safety and immunogenicity of the Chimeric SpiN-Tec MCTI UFMG Vaccine for Covid19	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2022-11-23	Centro de Tecnologia em Vacinas (CT Vacinas) da Universidade Federal de Minas Gerais	Fundação Oswaldo Cruz (FIOCRUZ)	https://ensaiosclinicos.gov.br/rg/RBR-3f598cj	<NULL>	"Part A: Healthy individuals aged 18 to 54 with completed primary vaccination schedule for COVID-19 with CoronaVac®. Have received a booster dose with Comirnaty® between 9 and 15 months before inclusion in the study.
Part A2: Healthy individuals aged 55 to 85 with a completed vaccination schedule for COVID-19 with CoronaVac® or Covishield® for at least six months from inclusion in the study. Have received at least one booster dose with Comirnaty® or Covishield® at least six months ago.
Part B: Healthy individuals aged 18 to 85 who completed the vaccination schedule for COVID-19 with CoronaVac® or Covishield® for at least six months from inclusion in the study. Have received at least one booster dose with Comirnaty® or Covishield® at least six months ago.
All Parties: Consent to the study and its procedures, documented by signing the Free and Informed Consent Form (TCLE). Present good general health as determined by medical examination. Women of childbearing potential must agree to use acceptable contraception* for at least 30 days before initiation of vaccination and at least 90 days following the use of the investigational product or active comparator. Agree not to donate blood while participating in the study.
Acceptable contraceptive methods: Barrier methods, including condoms or cervical caps. Surgically sterile partner/participant (including those undergoing vasectomy, hysterectomy, bilateral oophorectomy, and or tubal ligation) who is the only partner. Intrauterine device (with or without hormones) implanted. Birth control medications (oral, topical, injectable, or implantable). True sexual abstinence is in line with the patient&apos;s preferred and usual lifestyle. Note: periodic abstinence, such as calendar, ovulation, symptothermal, post-ovulation, or coitus interruptus methods, will not be considered a valid method."	"Part A: No previous history or acute infection with SARS-CoV-2. Previous records will be considered self-declaration by the participant. Vaccination booster for COVID-19 less than nine months ago and more than 15 months after inclusion in the study. The presence of comorbidities or any condition that, in the study investigator&apos;s assessment, could put the participant at risk or create a confounding factor in the study, including clinically stable chronic diseases.
Part A2: Acute SARS-CoV-2 infection or less than six months from the date of inclusion in the study. Vaccination booster for COVID-19 less than six months ago. The presence of comorbidities or any condition that, in the study investigator&apos;s assessment, could put the participant at risk or create a confounding factor in the study, including clinically stable chronic diseases.
Part B: Acute or SARS-CoV-2 infection or less than six months from the date of inclusion. Vaccination booster for COVID-19 less than six months ago. Any condition that, in the assessment of the study investigator, could put the participant at risk or create a confounding factor in the study. Diseases such as diabetes, hypertension, and clinically stable neuralgia may not constitute an exclusion criterion as determined by the medical investigator.
All Parties: Have received primary vaccination with Janssen or Comirnaty® vaccine. Have received a booster vaccine with the Janssen or CoronaVac® vaccine. History of SAE after administration of a COVID-19 vaccine. History of thrombophilia. Being on anticoagulant therapy or having a bleeding disorder that contraindicates intramuscular injection. Positive serology for HIV, HBV (HBsAg) or HCV. Laboratory abnormality in blood count, biochemistry, or urine tests. Exception will be defined by the clinical investigator when evaluated together with the participant&apos;s medical history. Women who are pregnant, breastfeeding, or intend to become pregnant/breastfeed within three months of inclusion in the study. Evidence of clinically active disease such as, but not limited to: neurological, renal, cardiovascular, endocrine, pulmonary, hepatic, hematological, immunological (including autoimmunities and immunodeficiencies), neoplastic or infectious disease. Psychiatric illness or cognitive impairment that, in the investigator&apos;s judgment, may affect the participant&apos;s ability to engage in the clinical trial following the established agenda. Alcohol abuse or use of illicit drugs in the last 12 months before recruitment has caused any family, medical, or professional problems. History of severe allergic reaction or anaphylaxis to any component of the vaccine. History of asplenia. Have participated in any other experimental clinical trial in the 12 months before inclusion or intend to participate in any experimental clinical trial in the 12 months following participation. Plans to participate in other clinical studies concurrently with this one. Use of some immunosuppressive therapy three months before recruitment or planning its use within three months after vaccination, including use of corticosteroids or other immunosuppressive medication (note: the immunosuppressive dose of corticosteroids is equivalent to 20 mg/day of prednisone per more than a week (topical or nasal corticosteroids are not considered immunosuppressive). Use of blood products (blood or immunoglobulins) within three months before inclusion or indication of their use during the study. Suspected active infection or confirmed fever (axillary temperature ≥ 38.0 oC) within 72 hours before inclusion. Recruitment should be delayed until the participant remains fever-free for 72 hours. Have received any live attenuated or inactivated vaccine within 28 days or 14 days, respectively, before use of the investigational product or active comparator or planning immunization within 28 days of study inclusion. History of use of medication authorized by ANVISA intended to prevent or treat COVID-19 less than six months before the study&apos;s inclusion date."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-2pnj8qp	The influence of a person organizing Care for Dependent Elderly people who receive care in primary health care	Recruiting	Intervention	2024-01-02	<NULL>	<NULL>	6697	Impact of a Care Management Model for Fragile Elderly people, supported by family health strategy teams	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-02	Faculdades Integradas Pitágoras de Montes Claros- FIPMOC	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-2pnj8qp	<NULL>	People aged 60 years or over; both sexes; registered and monitored by the Family Health Strategy - ESF teams; classified in relation to the degree of clinical-functional vulnerability	Long-term stay (equal to three months or more) in a hospital, institution or nursing home; record of receiving an alternative type of integrated care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-106bhfwy	Structured Respiratory Physiotherapy Protocol for Atelectasis in Pediatrics	Data analysis completed	Intervention	2024-01-02	<NULL>	<NULL>	6698	Structured Respiratory Physiotherapy protocol for resolution of Atelectasis in pediatric intensive care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-106bhfwy	<NULL>	Infants with 28 days to 24 months of age; both genders; on invasive mechanical ventilation for a period greater than or equal to 12 hours through an orotracheal cannula; diagnosed with Atelectasis by a pediatric intensive care physician through clinical and imaging examination (chest x-ray and lung ultrasound); whose legal guardians have authorized the child&apos;s participation in the study through the Free and Informed Consent Form	Patients with bilateral atelectasis; any type of air leak syndrome (such as: subcutaneous emphysema, pneumothorax, pneumatocele, pneumomediastinum); pulmonary hemorrhage; diseases that cause bone fragility (costal osteoporosis and osteomyelitis); chest and/or lung bruises; subcutaneous pacemaker; treatment with anticoagulants for more than 72 continuous hours; hemodynamic instability; thrombocytopenia (&lt;50,000 platelets); using a chest tube; with underlying neuromuscular or cardiac diseases and spinal deformities (kyphoscoliosis)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-8rgqzxf	Assessment of patients undergoing Echocardiography	Recruiting	Observational	2024-01-02	<NULL>	<NULL>	6699	Cohort of patients undergoing an Echocardiographic study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-01-01	Irmandade Santa Casa de Misericórdia de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-8rgqzxf	<NULL>	18 years or older. Underwent echocardiography at Santa Casa de Misericórdia de Porto Alegre. Both genders	No echocardiographic report available	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-23k6dgq	Speech Therapy and Covid-19	Recruiting	Intervention	2023-12-30	<NULL>	<NULL>	6694	Effects of Speech Therapy Intervention on Communicative, Cognitive, Olfactory and Swallowing Sequelae in patients with Severe presentation of Covid-19	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-23k6dgq	<NULL>	Subjects of any gender; residing and born in Brazil; aged over 18 years; people who had severe Covid-19; and patients who remained hospitalized	People who at some point in the research withdrew their free and informed consent; who have difficulty in orally answering the questionnaires; with cognitive and speech-language impairments prior to hospitalization; bedridden due to the difficulty of locomotion to participate in the research; those who test positive for Covid -19 at the time of the evaluations (due to the need to comply with isolation and the possibility of interfering in the acute phase of the disease with the test results); with reinfection of Covid-19 during the intervention period; with presence of hearing loss for admission to the language and cognition therapy group; patients with drug use that interfere with rehabilitation in the smell and swallowing therapy group	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-8gdcch5	Trigger tools for identifying adverse drug events in hospitalizated older people	Recruiting	Observational	2023-12-29	<NULL>	<NULL>	6693	Performance and applicability of triggers tool for detection of adverse drug events in hospitalized older people: a retrospective and prospective analysis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-01	Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual Paulista (UNESP)	Faculdade de Ciências Farmacêutica (FCF-RP). Universidade de São Paulo (USP)	https://ensaiosclinicos.gov.br/rg/RBR-8gdcch5	<NULL>	Older people (≥ 60 years old); admitted at least once to any hospital wards	Hospitalizations lasting less than 24 hours; admission for elective surgeries (e.g., admission for cataract surgery); admission for elective health procedures (e.g., transfusion of blood components, imaging exams or administration of specific medications)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-72nr8hc	The effect of a single laser application on respiratory muscle resistance in patients with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2023-12-28	<NULL>	<NULL>	6690	Acute effect of Low-level laser therapy on ventilatory muscle endurance in patients with Chronic obstructive pulmonary disease	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-72nr8hc	<NULL>	Volunteers diagnosed with chronic obstructive pulmonary disease stage 2, 3 or 4; both genders; non-smokers; aged 40 years or over; with a smoking history of over 20 pack-years and clinical stability in the 4 weeks prior to the study protocol.	Patients were excluded when: presenting any pulmonary disease other than COPD; current smoking; comorbidities such as heart failure; peripheral arterial disease; and self-reported significant cardiovascular events; or other comorbidities; neurological or orthopaedical; hat would compromise the ability to perform any of the study assessments and when presenting chronic obstructive pulmonary deases and severe exacerbation requiring hospitalization during the trial.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-4r5xs6d	The effectiveness of Psychotherapy for patients who have attempted suicide	Not yet recruiting	Intervention	2023-12-28	<NULL>	<NULL>	6691	Construction of Psychotherapeutic Resources for the treatment and prevention of Suicidal Behavior	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-10	Pro Reitoria de Pesquisa - Universidade Federal de Minas Gerais	Fundação Hospitalar do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4r5xs6d	<NULL>	Being 18 yeas old or over; both genders; residing in the city of Belo Horizonte; have been admitted to João XXIII hospital after a suicide attempt and have a reference person  who attends the first session	Participants cannot be considered legally incompetent; present a medical or psychiatric condition that prevents informed consent or participation in outpatient treatment, such as active psychosis or manic phase and present homicidal ideas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-75ys4s9	Effects of dance on health of patients with basal ganglia disease: a randomized controlled clinical trial	Recruiting	Intervention	2023-12-28	<NULL>	<NULL>	6692	Effects of dance on the quality of life of patients with basal ganglia disease: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-75ys4s9	<NULL>	Diagnosis of affection of basal ganglia, hyper or hypokinetic; hemodynamic stability; in use of prescribed medications and medical follow-up; both genders	Hemodynamic instability; without use of prescribed medications; without medical follow-up; withdrawal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-4vknryn	Cabbage in the treatment of Menopausal Genitourinary Syndrome	Recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6681	Randomized clinical study of the efficacy and clinical safety of Brassica oleracea in the treatment of Menopausal Genitourinary Syndrome - pilot study with analysis of quality of life and urogenital symptoms	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-20	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFM/USP	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4vknryn	<NULL>	Woman, age equal to or greater than 50 years and less than 65 years. Clinical menopause for at least 3 years and presence of GSM - Genitourinary Syndrome of Menopause - symptoms according to established diagnostic criteria.  FSH (follicle-stimulating hormone) measurement &gt; 25 IU/ml and estradiol &lt; 20 pg/mL, when it is not possible to predict the date of the last menstrual period. Diagnosis of genitourinary syndrome identified by clinical data and supported by the Vaginal Health Index questionnaire. Negative cervical cytology exam, within the routine timeframe recommended by the Ministry of Health/Instituto Nacional do Câncer (INCA)	Allergy to cabbage, broccoli, kale, or any plant from the Brassicaceae family. Patients with severe depression or any other mental health condition that impairs study participation or other study requirements. Intact hymen. Altered oncotic colpocytology of the cervix and/or vagina. Active or recurrent genital infections (genital herpes or candidiasis). Active connective tissue diseases. Congenital or acquired immunosuppression. Decompensated diabetes mellitus. Differential diagnosis of vulvar pathology (atrophic lichen sclerosus, vulvar intraepithelial neoplasia, and vulvar Paget&apos;s disease). Decompensated thyroid disorders. Use of systemic or local steroid hormones or herbal substances such as teas, sitz baths, compounded or commercial herbal products, or hormonal therapy within the past 3 months. Patients with decompensated chronic diseases. Acquired immunodeficiency virus carriers. Patients who have undergone pelvic irradiation, pelvic surgeries, or hysterectomy for malignant disease. Patients with current or ongoing neoplasms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-3xtxhtz	Effect of Low Pressure Fitness (LPF) on abdominal diastasis in postpartum women	Not yet recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6682	Effect of the Low Pressure Fitness (LPF) technique on rectus abdominis diastasis in postpartum women: blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-15	Faculdade de Ciências da Saúde do Trairi	Faculdade de Ciências da Saúde do Trairi	https://ensaiosclinicos.gov.br/rg/RBR-3xtxhtz	<NULL>	Primiparous or multiparous women aged 18 or over; from 12 weeks after birth, BMI less than or equal to 29 kg/m27; who gave birth vaginally to a single fetus after a full-term pregnancy; parity &lt;4; with a separation of the rectus abdominis muscles &gt;2 cm and ≥2 fingers wide, above, below or at the level of the navel; with the ability to adequately contract the Pelvic Floor Muscles and perform the hypopressive maneuver of the LPF® Method adequately; who do not have: history of previous cesarean section; perineal laceration; medical restriction that prevents participation in the proposed assessments and interventions (cardiorespiratory, respiratory (including excessive coughing or sneezing), neurological and/or musculoskeletal changes); any form of vulvovaginal pain, low back pain, pelvic pain, prolapse or incontinence; a pathology of the lower limb (e.g. fracture, surgery, neoplasm); history of pelvic or abdominal surgery; or with a history of smoking; history of multiple pregnancies; complications related to the last pregnancy, such as Polyhydramnios, fetal macrosomia, diabetes or hypertension	Postpartum women who are unable to understand and/or complete the study questionnaires; who have decompensated reflux and those who miss 3 consecutive sessions of the intervention protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-25ng5pt	Comparison of the use of a Biodressing and Laser Therapy for the treatment of Diabetic Foot Wounds	Not yet recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6686	Comparison between the use of a Biocuration and Low Intensity Laser Therapy in the treatment of Diabetic Foot Ulcers	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2024-03-31	Universidade Federal do Delta do Parnaíba	Universidade Federal do Delta do Parnaíba	https://ensaiosclinicos.gov.br/rg/RBR-25ng5pt	<NULL>	Volunteers of both sexes;aged over 18; with a clinical diagnosis of type 2 diabetes mellitus; diabetic ulcers located in the foot region;who agree to take part in the study by signing the Informed Consent Form (ICF)	Ulcers located in other regions of the body; who are unable to attend the treatment days proposed by the research; who are using other types of coverage for diabetic ulcers, which hinder the use of Laser and the identification of the results proposed by this research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-4bjwn32	The Effect of Electrical Brain Stimulation Along with Video Game, Horse Therapy, or Music Therapy on Hand Skills, Repetitive Behavior, and Comprehension in Children With Autism	Recruitment completed	Intervention	2023-12-27	<NULL>	<NULL>	6687	Effect of Transcranial Electrical Stimulation associated or not with Virtual Reality, Hippotherapy or Music Therapy on motor skills, repetitive behavior and social responsiveness of children with Autism Spectrum Disorder	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4bjwn32	<NULL>	Children aged 4 to 11 years old, of both sexes, who have a diagnosis of mild ASD, established by the Childhood Autism Rating Scale (CARS-BR), who have degrees of understanding and collaboration compatible with carrying out the proposed activities, will be included in the study. evaluated by the Motor Development Scale, who are in accordance with the Informed Assent Form (TA), Informed Assent Form (TAE) and whose parents or guardians are in accordance with the Free and Informed Consent Form (TCLE) for parents and/or or guardians, as well as with the ICF aimed at research participants, as they will actively participate by answering the study questionnaires.	Children who have other neurological and/or psychiatric disorders, epilepsy, metal implants in the brain or hearing aids will be excluded from the study; children with intellectual, sensory or motor disabilities; who are hyperirritable to music; who are allergic to horse hair; hip subluxation; uncontrolled hypertension or severe heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-9y34g7s	Evaluation of the effectiveness of galvanic vestibular stimulation in the rehabilitation of Mielopatia associada ao HTLV-1	Recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6688	Electrophysiological Exams to Test Auditory Cognition and Postural Balance in HTLV-1 Associated Myelopathy (HAM)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-07-30	Universidade Federal de Minas Gerais	Fundação de Amparo à Pesquisa do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9y34g7s	<NULL>	Control group: Composed of individuals with negative serology for HTLV-1 by the ELISA (Enzyme-linked-immunosorbent -assay) test;  Group with HTLV-1 infection: Composed of former blood donors from Fundação Hemominas with seropositivity defined by the ELISA test and confirmed through WB (Western Blot) or molecular tests (Polymerase Chain Reaction - PCR); HAM group: individuals with sufficient clinical signs, according to the criteria proposed by the adapted WHO (GRASSI et al, 2011; CASTRO-COSTA, 2006), classified according to the adapted Expanded Functional Disability Scale (EDSS) and OSAME presenting classification from two on both scales.	Positive serology for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), positive Venereal Disease Research Laboratory (VDRL) test; History of stroke and epilepsy ; Inability to remain in the examination position; Recurrent episodes of vertigo or history of previously diagnosed peripheral vestibulopathy;  Patients with a pacemaker or any device that may undergo changes resulting from the use of EVG; Cognitive changes justified by some other pathology associated with Parkinson&apos;s disease; Individuals who are alienated and unable to answer for their own actions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-7yqtbvk	Gel for orthodontic aligners	Not yet recruiting	Intervention	2023-12-27	<NULL>	<NULL>	6689	Chitosan gel and Melaleuca essential oil for orthodontic aligners - a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2025-03-03	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7yqtbvk	<NULL>	Participants will be included in the study: both sexes; aged between 18 and 30 years; absence of systemic disease known by the individual to affect periodontal tissues (such as cardiovascular diseases, diseases leading to neutropenia, diabetes, leukemia and AIDS); absence of periodontal disease prior to orthodontic therapy; absence of extensive restorations.	Participants who do not correctly follow the protocol for using gel in orthodontic aligners will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-1049dx8g	Eficacy and safety of Continuous and Micropulse Cyclophotocoagulation on the treatment of refractory Glaucoma	Not yet recruiting	Intervention	2023-12-22	<NULL>	<NULL>	6677	Eficacy and safety of Continuous and Micropulse Transscleral Cyclophotocoagulation on the treatment of refractory Glaucoma. A randomised clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-1049dx8g	<NULL>	Visual acuity better than or equal to light perception; diagnosis of refractory glaucoma, by the attending physician: uncontrolled intraocular pressure, presence of previous fistulizing glaucoma surgery and/or glaucoma drainage implant, contraindication to fistulizing surgery and glaucoma drainage implant; indication of cyclophotocoagulation by the attending physician	Under 18 years old; previous cyclophotocoagulation procedure; presence of retinal and/or choroidal detachment; presence of perilimbic scleral thinning or any other anatomical change that prevents transscleral cyclophotocoagulation; presence of an eye tumor; patients unable to perform the proposed exams or remain in the study for any reason	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-3nktynv	Validity and reliability of two body temperature thermometers during cycling in the heat: CALERA® Sensor and Exergen TAT5000 Temporal Scanner	Recruitment completed	Observational	2023-12-22	<NULL>	<NULL>	6678	Validity and reliability of two core temperature measurement techniques during physical exercise in the heat: CALERA® Sensor and Exergen TAT5000 Temporal Scanner	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal de Viçosa UFV	Universidade Federal de Viçosa UFV	https://ensaiosclinicos.gov.br/rg/RBR-3nktynv	<NULL>	Healthy adults; both genders; aged 18-59 years; considering the PAR-Q (Physical Activity Readiness Questionnaire) and the IPAQ (International Physical Activity Questionnaire); practitioners of regular physical activity in accordance with the recommendations of the American College of Sports Medicine (ACSM), who practice 30-60 minutes of moderate-intensity cycling, 5 days a week or 30-60 minutes of vigorous-intensity cycling, 3 days per week	People with disabilities of any nature; smokers; people with diagnosed cardiovascular or pulmonary complications; diabetics; and individuals with a history of thermal injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-4bwtfbc	Immediate effect of ischemia on muscle performance in CrossFit athletes	Not yet recruiting	Intervention	2023-12-22	<NULL>	<NULL>	6679	Acute effects of different Ischemic Preconditioning protocols on performance, strength and muscle activation of CrossFit practitioners: crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-02	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4bwtfbc	<NULL>	Healthy subjects; CrossFit practitioners; both genders; age between 18 and 35 years old; at least 1 year of practice; no history of metabolic, cardiovascular or locomotor system diseases that would contraindicate the practice of exercise and the use of vascular occlusion; Ankle Brachial Index between 0.91 and 1.30; respond negatively to all items on the Physical Activity Readiness Questionnaire	Present during the experiment any aggravating cardiovascular, pulmonary or musculoskeletal problems; not completing all the sessions proposed by the study; give up the same	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-7gfvn3y	Assessment of the self-care capacity of informal caregivers of elderly people living with Dementia	Not yet recruiting	Intervention	2023-12-22	<NULL>	<NULL>	6680	Self-care capacity of informal caregivers of elderly people with Dementia: quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de Mato Grosso	Universidade Federal de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-7gfvn3y	<NULL>	Being 18 years of age or older. Both genders. Being the main informal caregiver for elderly people with dementia. Being an informal caregiver for an elderly person with dementia for at least one year. Have access to a smartphone and internet and know how to use a messaging app	Have difficulty communicating, listening and understanding the questions asked by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-4wgg9bk	Can smartphones be an alternative to reducing sitting time?	Not yet recruiting	Intervention	2023-12-21	<NULL>	<NULL>	6671	Can Smartphone be an alternative to combat sedentary behavior?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4wgg9bk	<NULL>	Being 18 years of age or older; both genders; being duly registered; being regularly attending classes	Do not accept to participate in the research at any time; do not participate in one of the data collection moments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-7ccc397	The effect of using an Educational Booklet in relation to knowledge and adherence of Postoperative Care by patients in domicile	Recruitment completed	Intervention	2023-12-21	<NULL>	<NULL>	6672	Efficacy of an Educational Booklet on home care in Postoperative General Surgeries: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-7ccc397	<NULL>	Patients in the immediate postoperative period of general surgeries; who were in the transition from hospital to home; had some viable means of communication to perform the interview after applying the booklet in the hospital; age 18 or over; both genders	Participants who could not read, since to perform the use of the educational booklet it is necessary that the patient is literate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-6bj2czr	Ability of Laser Treatment on acupuncture spots on the control of Dry Mouth in patients with Sjögren Syndrome: randomized clinical trial	Recruiting	Intervention	2023-12-21	<NULL>	<NULL>	6673	Eficacy of Photobiomodulation Therapy on acupuncture spots on the control of Xerostomia in patients with Sjögren Syndrome: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6bj2czr	<NULL>	Volunteers with minimum age of 18 years-old and no maximum age limit; diagnosed with Sjögren&apos;s Syndromes according to the American College of Rheumatology and the European League Against Rheumatism	Patients with xerostomia that can not be related to Sjögren&apos;s Syndromes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-22mdrvy	Non-prescriptive low-carbohydrate nutritional approach in the remission of prediabetes (pDM2) and Type 2 Diabetes Mellitus (DM2)	Recruitment completed	Intervention	2023-12-21	<NULL>	<NULL>	6674	Effects of low-carbohydrate diet in the treatment of chronic non-communicable diseases	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-05	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-22mdrvy	<NULL>	Have a Diagnosis of Pre-Diabetes: Fasting blood glucose equal to or greater than 100 mg/dL and less than 125 mg/dL; Glycated Hemoglobin (HbA1c) equal to or greater than 5.7% and less than 6.5%; Blood glucose 2 hours after Oral Glucose Tolerance Test equal to or greater than 140 mg/dL and equal to or less than 199 mg/dL. Or have a diagnosis of type 2 Diabetes Mellitus: Fasting blood glucose equal to or greater than 125 mg/dL; Glycated Hemoglobin (HbA1c) equal to or greater than 6.5%; Blood glucose 2 hours after Oral Glucose Tolerance Test greater than 199 mg/dL. Participants may or may not be using oral anti-diabetic or antihypertensive medications. They must have a cell phone compatible with the WhatsApp® messaging application and be able to communicate by sending photos and texts. Be over 18 years old. Both genders. Agree with the protocol for treatment. Live in Belo Horizonte – MG. Sign authorization to participate in the research through the Free and Informed Consent Form (TCLE). Have a glucometer and agree to measure blood glucose 6x a day (1x a week for Diabetics and 1x a month for pre-diabetics)	Patients who have proliferative diabetic retinopathy (can enter the study only after laser photocoagulation therapy). Present reports, suspicion or diagnosis of gastroparesis. Have eating disorders (binge eating, anorexia, etc.). Being an athlete (more than 2 hours of exercise per day). Have a creatinine clearance &lt;60. Have albumin excretion above 300 mg/day (macroalbuminuria). Pregnant women. Nursing mothers. C-peptide below the reference value (&lt;0.6 ng/mL). Users of synthetic insulin. Vegans, vegetarians, frugivores	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-9k5tc4d	Assessment of pH stability and influence on tooth sensitivity after in-office dental whitening in adult patients: a double-blind randomized clinical trial	Not yet recruiting	Intervention	2023-12-21	<NULL>	<NULL>	6675	Influence and stability of pH on the sensitivity of in-office teeth whitening in adults: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-05	Faculdade de Odontologia da Universidade Federal do Amazonas	Faculdade de Odontologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-9k5tc4d	<NULL>	Participants over 18 years old; both genders; with good general and oral health conditions; caries-free upper teeth and upper anterior teeth free of restorations on the buccal surface; they should also have  A2 or darker colored central incisors, evaluated against a tooth value-driven visual color scale  (Vita Classical, Vita BleachedGuide)	Pregnant women; nursing mothers; smokers; users of fixed orthodontic appliances; with pre-existing anterior restorations; presence of severe intrinsic stains (stains due to tetracycline use, fluorosis and pulpless teeth); participants with a previous history of tooth sensitivity or any associated pathology (bruxism , gingival recession, non-carious lesion with exposed dentin)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-9hcby8c	Hormones in the plasma and milk of women in the first year postpartum: association with depressive symptoms and baby development	Recruiting	Observational	2023-12-19	<NULL>	<NULL>	6663	Adipocytokines in the plasma and breast milk of lactating mothers in the first year postpartum: association with depressive symptoms and cognitive and motor development of the infant	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-19	Instituto Nacional de Saúde da  Mulher da Criança e do Adolescente Fernandes Figueira/ Fundação Oswaldo Cruz	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9hcby8c	<NULL>	Breastfeeding mothers up to 15 days postpartum; aged between 20 and 45 of age; exclusively breastfeeding (offering only breast milk without tea or water in the 5 days preceding entry into the study); be free from chronic non-communicable diseases such as high blood pressure and diabetes, except obesity; residing in the city of Rio de Janeiro; be free from infectious diseases such as HIV; proficient in the Portuguese language; and whose newborns had an Apgar score ≥ 7 at the fifth minute	Breastfeeding mothers using antidepressant medication or other psychiatric medication; who had a twin pregnancy; who tested positive for Syphilis, Rubella, Toxoplasmosis, Cytomegalovirus, or Zika during pregnancy; who had gestational surrogacy/temporary uterine donation (&apos;gestational carrier&apos;); whose newborn had a premature birth, any pathology, inappropriate weight for gestational age, a diagnosis of any condition or malformation known to cause motor and/or cognitive deficits, or was admitted to a neonatal intensive care unit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-8x7534h	Comparative study of the effectiveness of two mouthwashes in reducing gingival inflammation in hospitalized patients	Recruitment completed	Intervention	2023-12-19	<NULL>	<NULL>	6664	Comparative study of the efficacy of Chlorexidine and Chloramine T in Gingivitis reduction in patients admitted to a referral hospital in Ceará	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-07-07	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-8x7534h	<NULL>	Normosystemic patients; of both sexes; aged between 30 and 65 years; oriented and cooperative; with autonomy to promote self-care regarding oral hygiene and with a mouthing and spitting reflex; presenting gingivitis and admitted to a ward	Confirmed history of allergy to Chloramine T 0.2% and Chlorhexidine 0.12% or components of formulas; pregnant or breastfeeding women; presence of infections in the oral cavity; patients with impaired self-care; individuals with a history of adverse reactions to chlorhexidine or components of the formula; patients/guardians who did not sign the free and informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-3pxmycv	Association of an Aerobic Exercise protocol with Systemic Photobiomodulation ) for treatment of women with Fibromyalgia	Not yet recruiting	Intervention	2023-12-19	<NULL>	<NULL>	6665	Effects of the association of an Aerobic Exercise protocol with Systemic Photobiomodulation (transcutaneous ILIB) on the level of pain, fatigue and quality of life in women with Fibromyalgia: a single blind randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-05	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-3pxmycv	<NULL>	Women; aged between 18 years and 60 years; who have been diagnosed with fibromyalgia (the diagnosis will be made by a patient&apos;s own referring physician and confirmed by a PhD physiotherapist with eight years of experience in the field of rheumatology, taking into consideration the diagnostic criteria for fibromyalgia set forth by the American College of Rheumatology); with cognitive capacity to understand the study according to the Mini Mental State Examination cutoff score; classified as little active and irregularly active according to criteria established by the International Physical Activity Questionnaire - short version; and interest in participating in the entire experimental protocol	Participants with uncontrolled systemic diseases such as diabetes mellitus and systemic arterial hypertension; neurological and musculoskeletal conditions that could directly interfere with assessments, such as paralysis, significant sensory alterations, advanced joint diseases (such as joint replacements or osteoarthritis); absolute contraindication to phototherapy, such as the presence of neoplasia; individuals with malnutrition (Body Mass Index -BMI) less than 18.5 kg/m2) or morbid obesity (Body Mass Index -BMI greater than or equal to 40 kg/m2)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5p2xfzd	Extra and Intraoral Low-Intensity Laser for Prevention and Treatment of Oral Lesions and Dry Mouth in Cancer patients: Double-Blind Randomized Controlled Clinical Study	Recruiting	Intervention	2023-12-19	<NULL>	<NULL>	6666	Extra and Intraoral Photobiomodulation for the Prevention and Treatment of Oral Mucositis and Xerostomia in Cancer patients: a Double-Blind Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-03	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5p2xfzd	<NULL>	Patients over 18 years old diagnosed with head and neck cancer will be included; Patients undergoing the first week of radiotherapy and/or chemotherapy with curative intent in the Oncology Sector of Hospital PUC-Campinas in the period from 2023 to 2024; Patients or guardians who agree and sign the Informed Consent Form	Patients who die during treatment (before completing the initially established sessions) will be excluded; Patients who give up oncological treatment before completion; Patients who were not in the first week of radiotherapy and/or chemoradiotherapy; Patients on palliative protocols;Patients with total loss of the maxilla or mandible as a result of the tumor; Patients who are unable to perform sialometry (difficulty spitting saliva); Patients who refuse to sign the Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-2bzty9v	Low Power Laser in Pain and Nipple injury due to Breastfeeding	Not yet recruiting	Intervention	2023-12-19	<NULL>	<NULL>	6668	Early Photobiomodulation in Pain and Nipple injury resulting from Breastfeeding	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-02	Universidade Estadual de Londrina - UEL	Centro de Ciências da Saúde - Departamento de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-2bzty9v	<NULL>	Mothers who are allocated in the rooming-in of the participating maternity hospitals; single pregnancy; gestational age equal to or greater than 37 weeks; nursing their babies; who has a smartphone to enable follow-up in the survey	Contraindication to breastfeeding; unpretentiousness to breastfeed; child with clinical conditions that may interfere with or prevent breastfeeding during the research period; anomalies in the breasts and/or nipples that may interfere with the breastfeeding process; contraindications for local photobiomodulation or transcutaneous ILIB: diagnosis of autoimmune disease (lupus or rheumatoid arthritis); tumor diagnosis; using antiplatelet medications; previous history of malignant pathology; pacemaker carrier, glaucoma; prior photosensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-10qpynpd	Caffeine gel-cream in the treatment of Gynoid Lipodystrophy	Recruitment completed	Intervention	2023-12-19	<NULL>	<NULL>	6669	Development and evaluation of a pharmaceutical system containing Caffeine for the treatment of Gynoid Lipodystrophy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Faculdade de Farmácia da Universidade Federal do Rio de Janeiro	Unidade de Farmácia da Universidade do Estado do Rio de Janeiro Campus Zona Oeste	https://ensaiosclinicos.gov.br/rg/RBR-10qpynpd	<NULL>	Female participant; participant between 20 and 40 years old; with gynoid lipodystrophy grade II or III in thighs and/or glutes bilaterally; with a body mass index between 18.5 and 29.9 kg/m2	Skin infection; an inflammatory process on the skin; cancerous lesions; psoriasis; active acne; active herpes; in other procedures; in other procedures during the last 6 months; allergic to any asset used; pregnancy or breastfeeding; restrictive diet for weight loss; athlete or high-performance sports	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-7jsgnsh	Study on the efficacy of Probiotics in the treatment of Asthma in children and adolescents	Recruiting	Intervention	2023-12-19	<NULL>	<NULL>	6670	Randomized, double-blind, controlled study on the efficacy of Combined probiotics in the treatment of Asthma in children and adolescents	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-04-24	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7jsgnsh	<NULL>	Children and adolescents between 6 and 20 years of age; Diagnosis of mild, moderate or severe persistent asthma, controlled or uncontrolled; Sensitization to at least 1 aeroallergen (prick test or specific IgE) and/or total IgE ≥ 100 kU/L.	Non-agreement to participate by the child/adolescent or parent/guardian; Allergy or serious adverse reaction attributable to the administration of the probiotic mixture or placebo; Failure to administer the medication correctly; Non-adherence to treatment (i.e. not using it regularly, as prescribed) for at least one continuous month; Failure to attend more than 50% of the assessments (clinical and/or laboratory) that will be carried out during the study; Previous known history of allergy to the probiotic mixture; Use of oral corticosteroids, immunosuppressants or immunobiologicals within 30 days prior to recruitment; Other chronic pneumopathies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-2gxd5pf	Association between tools for quantifying oral and systemic health in pediatric intensive care unit patients	Recruitment completed	Observational	2023-12-16	<NULL>	<NULL>	6662	Association between oral and systemic health scores in pediatric intensive care unit patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-06	Faculdade de Odontologia de Bauru - USP	Faculdade de Odontologia de Bauru - USP	https://ensaiosclinicos.gov.br/rg/RBR-2gxd5pf	<NULL>	Patients hospitalized at the study site, from 03 years of age until 01 day before their 18th birthday, evaluated by dentistry in the first 48 hours of hospitalization, and adding 02 to 03 dental evaluations until 06 days after the first dental evaluation.	Hospitalization time less than 6 days after the first dental evaluation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-2rm2w3k	Effectiveness of Continuous Lateralization Therapy for reducing pulmonary complications and pressure injuries in critically ill patients.	Recruiting	Intervention	2023-12-15	<NULL>	<NULL>	6660	Effectiveness of Platform-Based Lateralization Therapy in reducing interface pressure between the patient and the support surface	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-2rm2w3k	<NULL>	Adult and elderly patients, aged 18. Both genders. Patients at risk of developing Pressure Injury-  PI (Braden Scale score less than or equal to 18). Patient under controlled/assisted mechanical ventilation not yet eligible for weaning	Need for norepinephrine &gt; 1mcg/kg/min or mean arterial pressure &lt; 60 mmHg. Cardiac arrhythmias. Neurological diseases or symptoms, such as a history of seizures. Dependence on cardiac pacemaker. Air escape through chest drains, pneumothorax or undrained subcutaneous emphysema. Presence of previous Pressure Injury - PI during admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5pckbhj	Comparasion between Micropulse Ciclophotocoagulation and Slowcoagulation technics	Recruiting	Intervention	2023-12-15	<NULL>	<NULL>	6661	Micropulse Ciclophotocoagulation X Slow Coagulation : a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Hospital de Clinicas da Universidade Estadual de Campinas	Hospital de Clinicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-5pckbhj	<NULL>	Patients followed at the Glaucoma Service of the Hospital das Clínicas da Universidade Estadual de Campinas UNICAMP with refractory Glaucoma; who have no indication for filtering surgery or who refused to undergo an incisional procedure; having corrected visual acuity equal to or worse than 20/60, Intraocular Pression IOP &gt; 21 mmHg; age &gt; 18 years; both genders	Patients with Glaucoma secondary to uveitis; previous history of cystoid macular edema; ongoing ocular infection; or who have already undergone cyclophotocoagulation or cyclocryotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-7bvcpsg	Comparative effects of a mindfulness program developed for the brazilian context and an Internationally validated program on promoting mental health and socioemotional skills for children in public educational context	Recruitment completed	Intervention	2023-12-15	<NULL>	<NULL>	7712	Meditation and art therapy program for 9- and 10-year-old children as a promoter of mental health and socioemotional skills in the public educational context	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7bvcpsg	<NULL>	Ages between 9 and 10 years old; both sexes; informed consent from parents or guardians; enrolled and regularly attending a public elementary school	Students diagnosed with any psychological and/or psychiatric disorder; intellectual and cognitive disabilities; those using medication; those in the acute phase of such disorders; those already practicing meditation or related activities; or those who have done so in the past 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:30
RBR-104736f4	Study on the implementation of Long-Action Injectable Pre-exposure Prophylaxis in male adolescents who have sex with men and transgender individuals, aged 15 to 19, in Brazil. PrEP 15-19 Study	Not yet recruiting	Intervention	2023-12-14	<NULL>	<NULL>	6656	PrEP1519 (fase 2)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo	Instituto de Saúde Coletiva, Universidade Federal da bahia	https://ensaiosclinicos.gov.br/rg/RBR-104736f4	<NULL>	Self-identified men who have sex with men, non-binary assigned as male at birth, and transgender people; age between 15 and 19 years; HIV negative status (including HIV-rapid test for oral PrEP and HIV-viral load for CAB-LA PrEP) at screening/enrollment; at high risk for sexually acquiring HIV infection (condomless receptive or insertive anal intercourse in the 6 months prior to screening/enrollment, condomless vaginal intercourse in the last 6 months, any STI episode in the last 6 months, post-exposure prophylaxis (PEP) use at least once in the last 6 months, frequent use of alcohol or drugs before or during sexual intercourse, transactional or commercial sex); PrEP request by the participant who shows vulnerability and/or increased risk of HIV infection, based on risk management counseling and vulnerability context assessment by the research team	Weight under 35 Kg; currently participating in another interventional trial of PrEP agents, experimental medication or HIV vaccine trial; participant shows, according to a specialized psychological assessment, mental and/or intellectual impairment that do not allow PrEP use; only applicable for CAB-LA PrEP: surgically-placed buttock implants, including injected silicon, or fillers, per self-report; diagnosis of chronic hepatitis B2 with indication for antiviral treatment, alanine aminotransferase, ALT &gt; 2 times the upper limit of normal, ULN; total bilirubin &gt; 2.5 times ULN; Current or chronic history of liver disease, e.g., non-alcoholic or alcoholic steatohepatitis, or known hepatic or biliary abnormalities, with the exception of Gilbert&apos;s syndrome, asymptomatic gallstones, or cholecystectomy; any known coagulopathy that contraindicates receiving intramuscular injections; use of carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifampin and/or rifapentine; plan to relocate out of the area during the study period; a history or presence of allergy to the cabotegravir or its components; Only applicable for oral PrEP: estimated glomerular filtration rate, eGFR &lt; 60 mL/min/1.73m2; history of spontaneous bone fracture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-4k7dmm8	Benefits of Neuropsychomotor Intervention with Dance Therapy on Stress Management in adults and its relationship with levels of Cortisol and Brain-Derived Neurotrophic Factor	Recruitment completed	Intervention	2023-12-14	<NULL>	<NULL>	6657	Effects of Neuropsychomotor Intervention with Dance Therapy on Stress management and its relationship with levels of Cortisol and Brain-Derived Neurotrophic Factor in adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-25	Universidade Federal de Santa Catarina	Centro de Desenvolvimento Neuropsicomotor Ana Malheiros Ltda	https://ensaiosclinicos.gov.br/rg/RBR-4k7dmm8	<NULL>	Adults aged between 20 and 59 years ; who are classified as having stress levels above normal (stressed) according to the questionnaires (DASS-21 and/or PSS-10); of both sexes;  who reside in the city of Florianópolis or metropolitan region	Adults  under age range is outside of that proposed in the inclusion criteria; if they are not classified as having stress levels above normal (stressed) according to the questionnaires (DASS-21/eor PSS-10); adults who do not live in Florianópolis or the metropolitan region; adults with a diagnosis that prevents participation in the research (people with severe uncorrected hearing and/or visual impairment); with suspected or confirmed pregnancy; who are using any type of medication pharmacological treatment that may influence the variables evaluated (for example, antidepressants, anxiolytics, corticosteroids, statins, beta-blockers, anti-inflammatories, stimulants, etc.); adults diagnosed with some type of mental disorder, cardiovascular diseases, diabetes mellitus (DM), type 2 diabetes mellitus (DM2), Cushing&apos;s syndrome and Addison&apos;s disease; who regularly participate or have attended dance therapy programs in the last three month; smokers; research participants who do not carry out 75% of the planned interventions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-3pf736g	Evaluation of creatine supplementation on long-term Covid-related fatigue (fatigue study)	Recruiting	Intervention	2023-12-14	<NULL>	<NULL>	6658	Phase 2/3, randomized, closed, single-blind, three-arm study to evaluate the effect of creatine supplementation on long-term Covid-related fatigue (fatigue study)	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2023-02-27	Hospital das Clínicas da Faculdade de Medicina de Botucatu - HCFMB	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"", Faculdade de Medicina de Botucatu"	https://ensaiosclinicos.gov.br/rg/RBR-3pf736g	<NULL>	Adult men or women with a prior diagnosis of COVID-19 confirmed by documented testing. Presence of fatigue for more than 12 weeks after acute Covid-19 infection. Clinical stability. Negative pregnancy test for women of childbearing age. Understand, sign and date the written voluntary TCLE at the visit before any protocol-specific procedure. Be able and willing to comply with study visits and study procedures	Hospitalized individuals. Pre-existing, severe, uncontrolled organ failure which precludes participation in the study at the discretion of the investigators. Patients with pulmonary sequelae identified on chest CT scans performed prior to the baseline assessment. Pregnant or lactating women. Use of any investigational or unregistered product within the 3-month period or the 5-half-life period before the baseline period, whichever is longer. Any condition that, in the opinion of the investigators, could compromise the participant&apos;s safety or adherence to the study protocol, which includes the inability to perform physical exercise. Psychic disorders that prevent understanding of the proposed procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-8zypz4p	Action of two forms of ozone therapy application on clinical and biochemical parameters after wisdom teeth extraction: clinical, triple blind and randomized study	Recruitment completed	Intervention	2023-12-13	<NULL>	<NULL>	6654	Influence of two forms of ozone therapy application on clinical and biochemical parameters after third molar extractions: clinical, triple blind and randomized study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-29	Universidade Estadual Paulista Júlio de Mesquita Filho	Faculdade de Odontologia de Araçatuba- FOA UNESP	https://ensaiosclinicos.gov.br/rg/RBR-8zypz4p	<NULL>	Patients with favorable systemic and local health conditions; be between 16 and 35 years of age; both genders; with indication of tooth extraction of the lower third molars (elements 38 and 48), in position A or B and Pell &amp; Gregory classification I or II, with at least 2/3 of the root formed	Mandibular third molars in position C and Pell &amp; Gregory classification III; signs of local manifestations such as pericoronitis, cysts and odontogenic tumors associated or not with the third molar, trauma in the region, presence of infection or periodontal disease; patients with any systemic disease that interferes with the results of the procedure or who cannot use the drugs present in the study; presence of a history of hypersensitivity to drugs present in the study and to products used in the procedure, such as: 0.5% alcoholic chlorhexidine solution, 0.12% chlorhexidine digluconate solution and 2% mepivacaine hydrochloride solution with epinephrine 1:100,000; women who are menstruating, pregnant or breastfeeding during the study period; patients using medications to control psychiatric diseases, corticosteroids, estrogens and androgens	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-6874vff	Effects of High Intensity Training in patients who underwent Angioplasty	Data analysis completed	Intervention	2023-12-13	<NULL>	<NULL>	6655	Effects of High Intensity Interval Training in patients undergoing Primary Angioplasty	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Hospital Ilha do Leite (Hapvida)	Instituto de Cardiologia o Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6874vff	<NULL>	The main inclusion criteria to participate in the present study are participants between 40 and 65 years old; who underwent myocardial revascularization through angioplasty with occlusion ≥ 50%; must have preserved ejection function with an ejection fraction ≥ 40%; no signs of moderate or severe myocardial ischemia detected by perfusion scintigraphy; do not present with angina; do not present ischemia caused by physical exercise; not participate in any type of systematic physical activity; and be classified among those irregularly active	Those patients who present the following symptoms during the study will be excluded from the study. unstable angina; decompensated systemic arterial hypertension with SBP≥180 mmHg or DBP≥110 mmHg; drop in orthostatic pressure of 20 mm Hg with symptoms, significant aortic stenosis with aortic valve area of 1.0 cm2; uncontrolled ventricular or atrial arrhythmia; sinus tachycardia ≥120 bpm; third-degree atrioventricular block without a pacemaker; active pericarditis or myocarditis; recent embolism; acute thrombophlebitis; uncontrolled diabetes mellitus; have orthopedic limitations or any physical or mental limitation that prevents the performance of physical exercises; not attending at least 85% of physical training sessions or missing an entire week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-107wh2sv	Mindfulness to improve the Quality of Life of individuals with Chronic Diseases accompanied by the SUS in the State of São Paulo- Brazil	Data analysis completed	Intervention	2023-12-12	<NULL>	<NULL>	6651	Mindfulness to improve the Quality of Life of individuals with Chronic Conditions Primary Health Care in the State of São Paulo- Brazil	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade Federal de São Paulo	Universidade Federal de Pernambuco- Acadêmico de Vitória	https://ensaiosclinicos.gov.br/rg/RBR-107wh2sv	<NULL>	Volunteers diagnosed with cardiovascular disease - systemic arterial hypertension; Diabetes Mellitus; chronic respiratory diseases; chronic kidney disease; chronic liver diseases; bone and joint diseases; psychiatric illnesses, adults and elderly people, of both sexes, with a minimum age of 18 and a maximum of 70 years	Volunteers who are unable to read and/or write and/or understand the assessment questionnaires; moderate to severe cognitive impairment; individuals with decompensation or exacerbation of other Chronic Non-Communicable Diseases; pregnant women; individuals who have some serious psychopathology (for example, psychotic disorder, deep depression or substance use disorder) and/or who practice meditation at the time of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5g4g9bq	Effects of walking training in individuals with stroke	Data analysis completed	Intervention	2023-12-12	<NULL>	<NULL>	6652	Effect of total walking volume on functional mobility, gait, and cardiovascular risk in individuals with chronic stroke	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Associação das Pioneiras Sociais	Associação das Pioneiras Sociais	https://ensaiosclinicos.gov.br/rg/RBR-5g4g9bq	<NULL>	Medical diagnosis of a stroke that occurred at least 6 months ago and no participation in physical training or rehabilitation programs during the study period.	Inability to walk at least 10 meters without assistance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-2337ckv	Progressive exercises for people with a sprained ankle	Not yet recruiting	Intervention	2023-12-12	<NULL>	<NULL>	6653	Rehabilitation of individuals with ankle sprains in their different stages	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-2337ckv	<NULL>	Participants must be in a subacute phase of the ankle sprain (between one and eight weeks after the sprain event); of both sexes; and aged between 15 and 45 years	People with fractures in the ankle or foot region diagnosed after the sprain; treatments with a plaster splint that cannot be removed; the report of any neurological, musculoskeletal, cardiovascular, pulmonary or metabolic condition that may interfere with or contraindicate research procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-5b6q7vf	Task-Specific Training Approach involving Augmented Reality Games (Interact Protocol) in children with Spastic Cerebral Palsy: a randomized controlled trial	Not yet recruiting	Intervention	2023-12-11	<NULL>	<NULL>	6643	Task-Specific Training in an Augmented Reality Context (Interact Protocol) in children with Spastic Cerebral Palsy: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5b6q7vf	<NULL>	Children with a medical diagnosis of unilateral and bilateral spastic cerebral palsy; level of GMFCS (Gross Motor Function Classification System) I and II; who walk without walking aids; MACS (Manual Ability Classification System) I, II, and III; with modified Ashworth score from 0 to 1+; aged between 6 and 12 years; who understand simple verbal commands; with mass and height within the normal growth curve	Children who have dystonic, athetoid, or ataxic tonus classification; GMFCS level III, IV and V; MACS IV and V; with modified Ashworth score from 2 to 4 in limbs; with cognitive impairment that may compromise understanding of verbal commands; who receive orthopedic surgical procedures less than a year ago; with application of chemical blockages less than 6 months ago; with physical deformities that prevent or compromise the execution of the proposed activities; with use of medications that may alter strength or muscular tone; visual or auditory sensory deficits without correction with auxiliary devices; cardiorespiratory limitations of any intensity; who have undergone other intensive therapies less than 6 months ago; children that do not like video games	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-7h6b8mg	Effects of training with Immersive Virtual Games compared to Stationary Cycling on tremor, upper limb function and cognition in people with Parkinson&apos;s Disease: randomized clinical trial	Recruiting	Intervention	2023-12-11	<NULL>	<NULL>	6644	Effects of Immersive Virtual Reality training compared with Stationary Cycling on tremor, upper limb function and cognition in people with Parkinson&apos;s Disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Faculdade de Ceilândia da Universidade de Brasília	Associação de Centro de Treinamento de Educação Física Especial	https://ensaiosclinicos.gov.br/rg/RBR-7h6b8mg	<NULL>	Individuals of both genders; diagnosed with PD by a neurologist according to the MDS-PD criteria and selected by a physical therapist for study eligibility; classified in stages I to III according to the Hoehn &amp; Yahr classification; age between 50 and 85 years; presence of classic parkinsonian tremor type 1, according to the consensus statement of the Movement Disorders Society; Minimum score on the Mini Mental State Examination according to schooling median scores; normal or corrected visual and hearing acuity; Minimum schooling of 4 years of formal study; normal or corrected visual and hearing acuity; a minimum of 4 years of formal schooling	Individuals with other associated neurological diseases or conditions that prevent participation in the training; have previous experience with the Quest 2® system; be attending another specialized rehabilitation program; have a score higher than 5 on the Geriatric Depression Scale - GDS - 15 items; have undergone implantation of deep brain stimulation electrodes; present visible dyskinesia in upper limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-98xmt2n	Use of laser therapy in the treatment of neurosensorial disorders in facial surgery	Recruiting	Intervention	2023-12-11	<NULL>	<NULL>	6645	Use of low level laser therapy  in the treatment of neurosensory and motor disorders after maxillofacial surgery	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-08	Centro Universitário Serra dos Órgãos	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-98xmt2n	<NULL>	Healthy volunteers will be included in the research; both genders; age between 18 and 60 years old; indispensability of surgical treatment through oral and maxillofacial surgery; with sensory and/or motor changes in the face; patients who signed and agreed to the consent form	Patients who do not require a surgical approach, who refuse to participate in the research, patients with facial PAN fractures, orthognathic surgery patients and also patients with bilateral facial fractures will be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-3rnskcj	Deferoxamine to treat Iron Overload in patients on Dialysis: effect on bone, myocardial and liver	Data analysis completed	Intervention	2023-12-11	<NULL>	<NULL>	6646	Use of Deferoxamine in the treatment of Iron Overload in patients on Dialysis: impact on bone remodeling, myocardial function and liver storage	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-02-06	Hospital das Clinicas da Universidade de Sao Paulo	Hospital das Clinicas da Universidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3rnskcj	<NULL>	Adult patient on maintenance hemodialysisl; serum ferritin higher than 1000 ng/ml	Active smoking; Active use of alcohol; Previous use of desferoxamine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-8k52dw8	The effects of photobiomodulation on the gut-brain axis in adolescents with depression.	Not yet recruiting	Intervention	2023-12-11	<NULL>	<NULL>	6647	The effects of photobiomodulation on the gut-brain axis in adolescents with depression: a double-blind randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8k52dw8	<NULL>	All individuals of both sexes aged 15 to 17 years with a diagnosis of depression made by a physician will be included in this study. Participants must be duly enrolled and attending schools of the 8th Regional Education Management (GERED) in Campos Novos/SC.	Participants with cognitive problems and unable to answer the questionnaires will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-6s82bk3	Use of topical anesthetic before and after third molar removal surgery	Recruitment completed	Intervention	2023-12-11	<NULL>	<NULL>	6648	Pre and post surgical use of Topical Anesthetics in third molar removal Surgery: randomized, triple blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Centro Universitário Christus - UNICHRISTUS	Centro Universitário Christus - UNICHRISTUS	https://ensaiosclinicos.gov.br/rg/RBR-6s82bk3	<NULL>	Healthy individuals (American Society of Anesthesiologists - ASA I); of both sexes; aged between 18 and 35 years; in need of removal of lower third molars; third molars that present, on panoramic radiography, similar patterns of root formation, position and degree of impaction when comparing the right and left sides of each volunteer	Smokers; pregnant or breastfeeding women; users of medications prior to surgery that may interact with the patient&apos;s pain (e.g. NSAIDs, corticosteroids, analgesics); wearers of orthodontic bands on mandibular second molars; signs of any preoperative inflammatory or infectious condition; systemic diseases; neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-7k48gfd	Preoperative risk stratification of patients with Aortic Stenosis	Recruiting	Observational	2023-12-11	<NULL>	<NULL>	6649	New risk stratification based on Cardiac structural repercussion in severe Aortic Stenosis and its impact on prognosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Hospital das Clínicas da Faculdade de Medicina da USP	Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-7k48gfd	<NULL>	Severe Aortic Stenosis undergoing valve replacement surgery; age over 18 years; male and female genders	Severe aortic insufficiency; severe primary valvular heart disease; heart failure of non-valvular etiology; primary cardiomyopathies; severe obstructive pulmonary disease; endocarditis; three-vessel coronary disease; main stem lesion; previous cardiac surgery;active endocarditis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-4ttmrg6	Children&apos;s activities and social participation	Data analysis completed	Observational	2023-12-11	<NULL>	<NULL>	6650	Activities and social participation of children with atypical Motor Development	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-22	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4ttmrg6	<NULL>	Adults with 18 years of age or older; both genders; legal guardians of children aged up to 11 years and 11 months with motor disability in Physio-therapeutic care at the School Clinic on the Realengo, campus of the Federal Institute of Education, Science and Technology of Rio de Janeiro	Guardians of children with a health condition associated with the Nervous System without motor limitations;  guardians of children with other health conditions; guardians under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-4bqd9bd	Reconstruction of the knee ligaments with ankle tendon.	Recruitment completed	Observational	2023-12-09	<NULL>	<NULL>	6642	Knee ligament reconstruction with peroneus longus tendon graft	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-04-01	Santa Casa de Misericórdia de São Paulo	Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4bqd9bd	<NULL>	Patients with knee ligament injuries undergoing graft reconstruction.	Patients who lost a minimum segment of 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-6vk2vjr	Effects of Yoga in the treatment of Breast Cancer: a randomized clinical trial	Recruiting	Intervention	2023-12-08	<NULL>	<NULL>	6639	Effects of Yoga practice on cancer-related fatigue of patients undergoing primary treatment for Breast Cancer: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-6vk2vjr	<NULL>	To participate in the sample, participants must meet the following eligibility criteria: age equal to or greater than 18 years; diagnosis of stage I-III breast cancer; undergoing chemotherapy or radiotherapy; if you are undergoing radiotherapy treatment, you have already completed chemotherapy treatment; not present a history of severe cardiovascular disease that prevents the practice of physical exercise (with the exception of arterial hypertension controlled by medication); no active metastatic or locoregional disease; not have any severe physical or psychiatric condition that makes it impossible to exercise and not be engaged in regular exercise programs for more than 75 minutes a week.	Be under the age of 18; have already completed Primary treatment for breast cancer; presenting active metastatic or locoregional disease; have a severe physical or psychiatric condition that makes it impossible to exercise, be engaged in regular physical exercise programs for more than 75 minutes a week.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-4pdv53d	Nutritional intervention, based on the Brazilian Cardioprotective Diet, with a physical exercise program, both in online format, to control health parameters in people in the late postoperative period stomach reduction surgery	Recruiting	Intervention	2023-12-08	<NULL>	<NULL>	6640	Online multicomponent intervention, based on the Brazilian Cardioprotective Diet and a resistance training program, to control metabolic parameters in late postoperative period of Bariatric Surgery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-03	Faculdade de Ciências da Saúde da Universidade de Brasília	Faculdade de Ciências da Saúde da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4pdv53d	<NULL>	Adults who are physically inactive; age between 18 and 60 years; both sexes; submitted to bariatric surgery for more than 5 years, by the Unified Health System (SUS) or in private clinics; residents of the Federal District	Individuals who are physically active through the performance of any type of regular and/or programmed vigorous physical exercise; who presents any decompensated chronic illness or any evident illness that prevents from exercising; pregnant women; women who are breastfeeding; individuals who have psychiatric disorders in the use of psychotropic drugs; who use a pacemaker; in use of hormone therapy or on medication for weight loss; those who have any type of amputation; who do not have access to a cell phone or computer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-899fry6	Effect of photodynamic therapy on gum treatment in patients with Down Syndrome	Recruiting	Intervention	2023-12-08	<NULL>	<NULL>	6641	Evaluation of Antimicrobial Photodynamic Therapy as an adjunctive therapy to the treatment of Periodontitis in individuals with Down Syndrome: a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-10	Faculdade de Odontologia de Araçatuba FOA	Faculdade de Odontologia de Araçatuba FOA	https://ensaiosclinicos.gov.br/rg/RBR-899fry6	<NULL>	Patients with diagnosis of periodontitis stages III and IV grade C according to the new classification with interproximal clinical attachment level (CAL) ≥ 2 or ≥ 3 mm in more than 2 non-adjacent teeth; Patients of both sexes; Who had not received periodontal treatment within 3 months with at least 2 sites with probing depth (PD) ≥ 4mm and a minimum of 15 teeth present in the oral cavity, excluding third molars	Smokers or ex-smokers for more than 5 years; Patients with anemia; Patients with active cancer and history of chemotherapy; History of antibiotic therapy in the previous 3 months; History of anti-inflammatory therapy in the last 3 months; Patient with blood disorders; Patient undergoing orthodontic treatment; Patients who required prophylactic antibiotic therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-9x9kctn	Effects of Repetitive Transcranial Magnetic Stimulation (rEMT) in Obesity	Recruiting	Intervention	2023-12-07	<NULL>	<NULL>	6635	Effects of Repetitive Transcranial Magnetic Stimulation (rEMT) on subjective signs of hunger and satiety in Obesity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-17	Instituto de Neuromodulação e Reabilitação Avançada (INERVA)	Instituto de Neuromodulação e Reabilitação Avançada (INERVA)	https://ensaiosclinicos.gov.br/rg/RBR-9x9kctn	<NULL>	Adult volunteers; 18 to 59 years of age; of both sexes; diagnosed with obesity to any degree for body mass index (BMI)	Eutrophic, overweight and malnourished volunteers for BMI; who have contraindications to rEMT or have received rEMT in the last 12 months; who present any head injury, previously documented epilepsy, presence of psychiatric disorder (schizophrenia and bipolar disorder); who have metal implants in their heads; who use or have used anti-obesity drugs (sibutramine, topiramate, orlistat and liraglutide) in the last 3 months; who are addicted to illicit drugs in the last 5 years; who have Cushing&apos;s Syndrome; who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-87kzkbm	Association between glucose control and exercise capacity in Type 1 Diabetic adolescents	Not yet recruiting	Observational	2023-12-07	<NULL>	<NULL>	6636	Association between glycemic control and cardiorespiratory fitness in Type 1 Diabetic adolescents	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-08	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-87kzkbm	<NULL>	For the Type 1 Diabetes Mellitus (DM1) group: Individuals, female, with a clinical and laboratory diagnosis of DM1; aged between 13 and 17 years; classified as pubertal (from P3M3), according to biological maturation; agreeing to the procedures and signing the Free and Informed Assent Form and the Free and Informed Consent Form. For the control group: individuals without a clinical or laboratory diagnosis of DM1; agreeing to the procedures and signing the Informed Consent Form and the Informed Consent Form; matched by age, biological maturation and level of physical activity with the participants in the DM1 group	For the Type 1 Diabetes Mellitus (DM1) group: presence of complications such as diabetic retinopathy, nephropathy and/or neuropathy; respiratory exchange coefficient lower than 1.1 in the Cardiopulmonary Exercise Test; loss of data related to the variables of the Cardiopulmonary Exercise Test; absence of information or incorrect completion of information on the time of diagnosis of diabetes, laboratory tests, body composition and level of physical activity. For the control group: respiratory exchange coefficient lower than 1.1 in the Exercise Cardiopulmonary Test; loss of data related to the Exercise Cardiopulmonary Test variables	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-9x5zrgm	Influence of protocols with Lasertherapy for the prevention of chemotherapy-induced dysgeusia in patients with breast cancer	Recruiting	Intervention	2023-12-07	<NULL>	<NULL>	6637	Influence of different photobiomodulation protocols on prevention of chemotherapy-induced dygeusia in patients with breast cancer treated with doxorubicine-cyclophosphamide and taxans: Phase III clinical trial, randomized, triple blind.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-03	Universidade Federal do Ceará	Instituto do Câncer do Ceará - ICC	https://ensaiosclinicos.gov.br/rg/RBR-9x5zrgm	<NULL>	Patients over 18 years old; breast cancer stages II, III and IV; adjuvant, neoadjuvant or palliative; treatment with drugs Doxorubicin, Cyclophosphamide and Taxol	Radiotherapy to the head and neck; smokers; anemia; untreated diabetes mellitus; after COVID-19	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-6pvj72b	Effect of Brazilian foods on glycemia	Recruitment completed	Intervention	2023-12-07	<NULL>	<NULL>	6638	Glycemic response of Brazilian foods	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-07	Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6pvj72b	<NULL>	Age between 18 and 45 years old; both genders; must be in good health; according to report on the absence of diabetes; kidney and gastrointestinal diseases; hyperthyroidism; underweight or overweight/obesity and report of family history of diabetes; volunteer women cannot be pregnant; breastfeeding or report hormone therapy; and all individuals must be exempt from the use of any type of medication that may affect the digestion and absorption of food (antibiotics; medication for diarrhea; and intestinal constipation) during the study period	Overweight/obese individuals (BMI≥25 kg/m2); and underweight (BMI≤18.6 kg/m2) according to criteria of the World Health Organization (WHO, 1997); previous diagnosis of diabetes mellitus or carrier family members; with possible eating disorders (anorexia; bulimia) or intestinal problems (chronic diarrhea; irritable bowel syndrome; Crohn&apos;s disease; ulcerative colitis); reports of illness; pregnancy; treatment of any kind	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-103g7j28	Different local anesthesia and photobiomodulation on the surgiers of third molars extraction	Recruiting	Intervention	2023-12-07	<NULL>	<NULL>	6739	Analysis of different local anesthesia and photobiomodulation on the surgiers of third molars extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-103g7j28	<NULL>	Over 18 years of age, have good oral hygiene (plaque index &lt; 20%), have all four third molars and have indication for dental extraction of all third molars	Patients with periodontal disease, patients with systemic diseases or conditions or who use drugs that alter bone metabolism (except diabetics), decompensated diabetics (glycated hemoglobin above 8%), pregnant or lactating women, heavy smokers (above of 10 cigarettes daily), presence of periapical lesions, presence of pericoronitis lesions, patients allergic to penicillins	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-26d4nwz	Evaluation of the epidemiological profile tailored to dysfunctions of the urinary tract, intestinal and sexuality of people with Spinal Cord Injury in Brazil	Not yet recruiting	Observational	2023-12-06	<NULL>	<NULL>	6632	Epidemiological profile of patients with Spinal Cord Injury: dysfunctions of the urinary, intestinal and sexual systems	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-26d4nwz	<NULL>	Patients with a spinal cord injury; regardless of gender and ethnicity; aged 18 years or over; who wished to participate in the research	Individuals who do not meet the inclusion criteria described above; people with cognitive or communication limitations that make it impossible to properly conduct the interview	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-10gjvcyt	May geometric modifications of implants influence implant repair in smokers?	Data analysis completed	Intervention	2023-12-06	<NULL>	<NULL>	6633	Clinical study of the influence of different macrogeometries and surface treatments of dental implants inserted in smoking patients. Clinical aspects and immunological	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-15	Universidade Paulista	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-10gjvcyt	<NULL>	Smokers who smoke more than 10 cigarettes/day; aged between 18 and 65 years; both genders; with the presence of at least 20 teeth in the oral cavity; bilateral and homologous unitary prosthetic space	Presence of systemic diseases that could interfere with bone regeneration, such as diabetes, arthritis, hypothyroidism, hyperparathyroidism, and osteoporosis; pregnancy or breastfeeding; use of medications that counter-indicated the performance of surgical procedures or that could alter bone regeneration around implants (e.g., anti-inflammatory and bisphosphonate drugs); absence of keratinized tissue at the implant insertion sites (may interfere with hygiene around the implants); need for bone or tissue grafts	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-4yhwvvc	Photodynamic therapy with toluidine blue (t-bu) in the treatment of periodontitis in type 2 diabetic patients	Recruiting	Intervention	2023-12-06	<NULL>	<NULL>	6634	Effect of aPDT mediate by  Toluidine Blue (t-Bu) on the periodontal treatment of residual pockets in diabetes mellitus patient: a randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-4yhwvvc	<NULL>	Patients aged ≥ 30 and ≤ 70 years; diagnosis of periodontitis according to the new classification with interproximal clinical attachment level (CAL) ≥ 2 or CIN ≥ 3 mm in more than 2 non-adjacent teeth (excluding the CAL limits cited in cases related to periodontitis: gingival recession of traumatic origin; caries; teeth extending into the cervical area of ​​the teeth; presence of CAL distally to the second molar and associated with poor dental position or extraction of the third molar; endodontic lesion reaching the gingival margin and occurrence of vertical root fracture); who have undergone periodontal treatment within a maximum period of 3 months with at least 4 sites with PD ≥4mm with BOP; patients diagnosed with type 2 diabetes mellitus (HbA1c ≥ 7.0%); have at least 15 teeth, excluding third molars	Smokers or ex-smokers for more than 5 years; patients with anemia; patient with active cancer and history of chemotherapy; antibiotic therapy within the previous 6 months; hx of anti-inflammatory therapy in the past 6 months; patient with blood disorders; pregnancy; patient undergoing orthodontic treatment, patients requiring prophylactic antibiotic therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-75yp56r	The Effect of Clinical Simulation on Teaching and Learning in occupational therapy	Not yet recruiting	Intervention	2023-12-05	<NULL>	<NULL>	6630	The Effect of Clinical Simulation on Teaching and Learning in occupational therapy: a quasi-experiment	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-75yp56r	<NULL>	Undergraduates aged eighteen or over; regularly enrolled in the seventh and eighth periods; in the occupational therapy course at Federal University of Triangulo Mineiro; who are taking the following courses  Supervised Internships one, two, three, and four; the study will be carried out with fifty-three occupational therapy graduates from the Federal University of Triângulo Mineiro; the sample size calculation will be carried out after the pilot study	Students with signs and symptoms of flu syndrome; pregnant women; students with medical conditions and symptoms of flu syndrome; students with medical conditions that make it impossible to transfer the that make it impossible to safely transfer the patient from the bed to the wheelchair; inactive students; students on sick leave; students who did not take part in any of the any of the research stages	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-8pjxs75	Technology in Postural Education in Online and Online Format for elementary school students	Not yet recruiting	Intervention	2023-12-05	<NULL>	<NULL>	6631	Technology in Postural Education in Online and Online Format for Elementary School Students: A Non-Randomized Clinical Trial	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2024-01-25	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8pjxs75	<NULL>	Children of both sexes, aged between 6 and 12 years old, who understand the tests to be carried out and agree to participate in the postural intervention; adolescents of both sexes, aged between 10 and 17 years old, who understand the tests to be carried out and agree to participate in the postural intervention; enrolled and attending public and private schools in municipalities in the South of Brazil;teachers of both sexes and different subjects from participating schools; parents and/or legal guardians of participating students	students with diagnosed motor and cognitive disabilities, previously acquired physical disabilities, congenital and neurological changes; students who do not attend 2/3 of the Technology in Postural Education Online and In-person Program interventions; teachers who do not attend training programs;Illiterate parents and/or guardians	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-7j6d23v	Hydration, nutrition, gastrointestinal symptoms and sleep profile in 12h and 60h ultramarathons	Recruitment completed	Observational	2023-12-04	<NULL>	<NULL>	6628	Hydration, nutritional, gastrointestinal and sleep profile in 12h and 60h ultramarathons	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7j6d23v	<NULL>	Ultramarathon athletes; over 18 years old, with a minimum of 2 years of ultramarathon experience; registered in the individual category of the 217 km “Brazil 135 Ultramarathon”; Members of the athletes&apos; support team must also be over 18 years old and support the athlete during the race	Volunteers who present any motor or cognitive limitation that compromises the performance of the assessments proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-8cykwc3	Comparative study between lung expansion maneuvers in patients undergoing mechanical ventilation	Recruitment completed	Intervention	2023-12-04	<NULL>	<NULL>	6629	Comparative study between alveolar recruitment maneuvers, chest compression and decompression maneuvers and breath stacking maneuvers in patients undergoing mechanical ventilation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Hospital e Maternidade Galileo	Hospital e Maternidade Galileo	https://ensaiosclinicos.gov.br/rg/RBR-8cykwc3	<NULL>	Patients with up to 72 hours of admission to the Intensive Care Unit (ICU) using mechanical ventilation (MV); patients of both sexes; aged 18 to 80 years; patients with hemodynamic stability, mean arterial pressure (MAP≥60 mmHg), pulmonary gas exchange with partial pressure of oxygen greater than or equal to 60 mmHg (PaO2 ≥ 60 mmHg), inspiratory fraction of oxygen greater than or equal to 60% (FiO2≥60 %), positive expiratory pressure less than or equal to 10 cmH2O (PEEP≤10 cmH2O), adequate oxygen saturation (SpO2≥95%), acid-base balance; sedated or weaned patients; informed consent form signed by the responsible family member	Bronchopleural fistula; pulmonary thromboembolism; patients undergoing postoperative cardiac surgery; thrombocytopenia (&lt;50,000/mm³); severe traumatic brain injury with intracranial hypertension (PIC≥20mmHg); flail chest and undrained pneumothorax	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-3sm2q4p	Study of the agreement on diagnostic of gingival thickness in the anterior superior teeth	Recruiting	Observational	2023-12-01	<NULL>	<NULL>	6625	Study of the agreement on diagnostic of gingival phenotype in the anterior maxilla: a clinical and tomografic study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-01	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-3sm2q4p	<NULL>	Healthy, natural teeth anterior maxilla	Medical compromises, abcenses of sone tooth on anterior maxilla or reshabilitation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-77h8fhf	Effects of Traditional Resistance Training and Co-Contraction on the strength and hypertrophy	Recruiting	Intervention	2023-12-01	<NULL>	<NULL>	6626	Effects of Traditional Resistance Training and Co-Contraction on the strength and hypertrophy of elbow flexor and extensor muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-77h8fhf	<NULL>	Adults aged between 18 and 35 years of both sexes; without musculoskeletal injuries in the last 12 months; and with no medical contraindications for physical exercise	Inability to train at the proposed times; a history of musculoskeletal injury in the upper limbs within the last 12 months; and the presence of any health issues that may interfere with the execution of the proposed exercises and assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-4742kxf	Benefit and safety of Physical Training with alternating High Intensity Exercise compared to Fixed Load Exercise in patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension	Recruiting	Intervention	2023-12-01	<NULL>	<NULL>	6627	Efficacy and safety of Cardiopulmonary Rehabilitation with High Intensity Interval Training compared to Constant Load Training in patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-14	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4742kxf	<NULL>	These are patients with a previous diagnosis of Pulmonary Arterial Hypertension or non-surgical Chronic Thromboembolic Pulmonary Hypertension or residual post-thromboendarterectomy; Modified New York Heart Association (NYHA) functional class I, II and III; Specific pharmacological treatment for Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension optimized and available in Brazil and stable for at least 3 months or at least 6 months post-thromboendarterectomy	Presence of syncope in the last 30 days or signs and symptoms of clinical instability in the last month, worsening of dyspnea, pre-syncope or need for increased diuretics due to edema or hospitalization; Other diagnosis of Pulmonary Hypertension group II, III and V; Functional class IV; Musculoskeletal diseases that contraindicate or impair carrying out exercise testing on a cycle ergometer or carrying out rehabilitation; Need for additional specific therapy during the rehabilitation period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-5fysqrh	Effects of Ivabradine on Cardiac Circulation in patients with Angina	Recruitment completed	Intervention	2023-11-30	<NULL>	<NULL>	6622	Benefits of Ivabradine on Myocardial Perfusion in Chronic Stable Angina Pectoris	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2019-11-21	Medicina Nuclear do Alto da XV	Medicina Nuclear do Alto da XV	https://ensaiosclinicos.gov.br/rg/RBR-5fysqrh	<NULL>	Patients with chronic stable angina pectoris; aged between 18 and 70 years; who remain symptomatic despite of using beta blockers (maximum tolerated dose) and HR ≥ 70 bpm; sinus rhythm; LVEF &gt;40%; and any ischemia in baseline myocardial perfusion scintigraphy; performed with a physical stress test; in accordance with previous drug therapy	Unstable angina; Myocardial infarction &lt;6 months; LVEF &lt;40%; HR &lt;70 bpm; presence of left bundle branch block; pacemaker; patients who cannot perform a treadmill stress test (physical limitation); pregnancy, breastfeeding  or women in childbearing age who are not taking appropriate contraceptive methods; patients with hypersensibility to ivabradine or any component of the formula, cardiogenic shock, acute myocardial infarction, severe hypotension; and patients with contraindication to perform a myocardial scintigraphy.And also strict precautions (ie contraception) are needed in women of childbearing potential (because ivabradine and scintigraphy)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-7f42fs5	Evaluation of Local and Systemic Laser Application in Dental Implant Surgery: Clinical study	Recruiting	Intervention	2023-11-30	<NULL>	<NULL>	6623	Clinical evaluation of Local and Systemic Photobiomodulation in Dental Implant Surgery: Clinical study ramdomized	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7f42fs5	<NULL>	Patients over 18 years of age with an indication for dental implants will be included in the study according to the following inclusion criteria: Patients with an indication for upper (maxilla) and/or lower (mandible) single dental implants in healed sockets (at least 60 days after extraction); Healthy oral mucosa. A prior clinical analysis will be carried out and the patient must present no mucosal disease, that is, no phlogistic (inflammatory) and infectious signs; Patients who agree to participate in the research by signing the Informed Consent Form	Patients with systemic diseases, such as: diabetes mellitus, cardiovascular diseases, coagulation disorders, osteoporosis and/or hypertension; Patient undergoing radiation to the head or neck; Patients with a history of implant loss; Pregnant or lactating women; Sensitivity to light (photophobia); Smokers and alcohol addicts; Patients using medications that alter bone metabolism, such as: heparin, warfarin, cyclosporine, glucocorticoids, medroxyprogesterone acetate, oncological medications, thyroid hormone, prednisone, prednisolone, methylprednisolone, dexamethasone, cortisone and triamcinolone; Patients who have been or are being treated with antibiotics or anti-inflammatories for less than 2 weeks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-5r7zrs2	The effect of photobiomodulation therapy on Menopause	Not yet recruiting	Intervention	2023-11-30	<NULL>	<NULL>	6624	Effect of Photobiomodulation Therapy on Genitourinary Syndrome of Menopause: blinded, controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-5r7zrs2	<NULL>	Women who had natural menopause at least 1 year ago; aged between 45-65 years; without use of hormone replacement therapy for at least 3 months; being sexually active; presenting a diagnosis of sexual dysfunction and urinary incontinence; not performing exercises for the pelvic floor muscles; have a negative Pap smear result for cervical cancer precursor cells in the last year	Women who present null value in the International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF); score above 26.55 in the Female Sexual Function Index (FSFI); those unable to understand simple verbal commands or who do not comply with the guidelines provided during the evaluation; volunteers with infectious and degenerative diseases; those who present genital prolapse III or IV according to the Baden-Walker Scale; report of unbearable pain during the gynecological evaluation; have more than 20% absences in the period of intervention; those who decide not to continue in the research and/or withdraw their consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-26rcv2n	Application of Physiotherapeutic Devices in patients with Lombalgy	Not yet recruiting	Intervention	2023-11-29	<NULL>	<NULL>	6618	Application of Electrothermalphototerapeutic Current in patients with Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-26rcv2n	<NULL>	Localized lumbar pain; female and male; age 18 to 85 years; numerica pain scale (NPS more than 3; with more than 6 weeks; characterized chronic lumbar pain; lumbar pain with mechanic ethiology	pregnant women; lactating women; sedentary individuals; Body Mass Index (BMI) greater than or equal to 30 kg/m2; without physical therapy treatment simultaneously with the study period; surgery in the lumbar region; without clinical diagnosis of low back pain; not present low back pain radiating to the glutes and lower limbs; sensory alteration in the lower limbs and the use of medication to relieve low back pain 48 hours before the performance of the exercises;  neurological disease, previous diagnosis of heart disease; acute lung disease; uncontrolled hypertension beginning of medication use less than 1 year ago); orthopedic injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-24phkvj	Impact of the dietary on Temporomandibular Dysfunction	Recruitment completed	Observational	2023-11-29	<NULL>	<NULL>	6619	Impact of the dietary profile on Temporomandibular Dysfunction	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-20	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-24phkvj	<NULL>	Female volunteers; aged between 20 and 45 years; who seek care in the UFC Dentistry course; they must present a pain complaint of at least 5, measured based on a Numerical Scale (NS); complaint of main pain in the region of the masseter muscle; no history of previous treatment for at least three months	Previously diagnosed disabling cognitive, psychological and neurological alterations; other chronic pain disorders; licit drug and/or alcoholic beverage abuse; illicit drug use; pregnant and lactating women; volunteers with loss of five or more dental elements; ill-fitting prostheses; severe periodontal disease; odontal diseases; intra or extra-oral lesions capable of compromising masticatory function; food intolerances; diabetes mellitus and/or other systemic conditions capable of generating dietary restriction; women with body mass index over 30.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-8s3qz5s	Pre-Exposure Prophylaxis (PrEP) Implementation study of long-acting injectable cabotegravir (CAB-LA)	Recruiting	Intervention	2023-11-29	<NULL>	<NULL>	6620	An Implementation study of long-acting injectable cabotegravir (CAB-LA) for HIV Pre-Exposure Prophylaxis (PrEP) among young MSM, non-binary and transgender persons	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Instituto Nacional de Infectologia Evandro Chagas - INI/Fiocruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-8s3qz5s	<NULL>	"Cisgender, non-binary (assigned male at birth) or transvestite men, transgender men and women; Report of anal sex in the past six months with a person who was assigned male at birth (Persons born female who have had sex only with people born female are excluded); Age from 18 to 30 years old; Report to the study center looking for PrEP; 
PrEP-naïve with CAB LA or oral PrEP with TDF/FTC; Willing and able to provide written informed consent and adhere to study requirements; Non-reactive/negative HIV test results, including rapid HIV tests and an undetectable HIV RNA test at enrollment for individuals who choose injectable CAB-LA; No reports of liver dysfunction. Applicants who report liver disease will have their enrollment visit postponed until laboratory results of liver function tests are available. See Section 7 (Study Procedures - Inclusion Visit); Willing to undergo all necessary study procedures."	One or more reactive or positive HIV test results at the enrollment visit, even if HIV infection is not confirmed; Currently participating in a PrEP agent intervention trial, HIV vaccine trial, or experimental medication trial; Positive pregnancy test, breastfeeding or intent to become pregnant during study enrollment (for trans men); Previous participation in studies with Cabotegravir; History or presence of allergy to study drug components; Past participation in an HIV vaccine trial. An exception will be made for participants who can provide documentation of placebo receipt (non-active arm); Planning to relocate outside the area during the study period; Injected or surgically placed buttock implants or fillers, by self-report; Have a dermatological/inflammatory skin condition overlying the buttock region which, in the opinion of the study investigator, in consultation with the Clinical Study Coordination (CSC), may interfere with the interpretation of injection site reactions; Active or planned use of a contraindicated co-administered drug for which significant decreases in plasma concentrations of Cabotegravir may occur due to uridine diphosphate glucuronosyltransferase (UGT1A1): • Anticonvulsants: Carbamazepine, Oxcarbazepine, Phenobarbital, Phenytoin • Antimycobacterial: Rifampicin, Rifapentine; Current or anticipated need for chronic systemic anticoagulation or history of known or suspected bleeding disorder, including history of prolonged bleeding; History of severe liver failure (including, but not limited to, history of liver failure or hospitalization for liver disease, history of hepatocellular carcinoma or near liver transplant); Individuals with advanced Hepatitis C; Other medical conditions that, in the opinion of the study investigator, interfere with the conduct of the study (eg, provided by self-report or found by the physician).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-7n6n5sd	Development of a diagnostic kit for simultaneous and low-cost detection of viral and bacterial agents associated with Acute Respiratory Infections	Recruitment completed	Observational	2023-11-29	<NULL>	<NULL>	6621	Development of RT-qPCR-HRM for simultaneous detection and low cost of viral and bacterial agents associated to Acute Respiratory Infections	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-09-01	Instituto Nacional de Controle de Qualidade em Saúde	Instituto Nacional de Controle de Qualidade em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7n6n5sd	<NULL>	Clinical samples from participants aged 18 years or over; of both genders; samples with complete information and registered in the Sistema de Ambiente laboratorial (GAL), containing clinical data of patients who were suspected of having COVID-19; samples considered positive for SARS-CoV-2 whose ct (cyclethreshold) is ≤40; samples negative for SARS-CoV-2, with ct (cyclethreshold) &gt;40; acute samples less than 10 days after the onset of respiratory symptoms; samples properly stored at -80ºC; clinical samples from participants with confirmed clinical signs of infections	Participants whose clinical sample does not have sufficient volume to perform the investigational test (volume less than 100 µL); samples registered in the Laboratory Environment System (GAL) with incomplete information; samples stored in conditions unsuitable for the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:50
RBR-462vwq5	An oral inflammatory disease and the relationship in the development of nosocomial pneumonia	Data analysis completed	Observational	2023-11-28	<NULL>	<NULL>	6615	Periodontitis in the development of ventilator-associated Pneumonia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-01	Centro de Ciências Biológicas e da Saúde CCBS - UNIOESTE	Centro de Ciências Biológicas e da Saúde CCBS - UNIOESTE	https://ensaiosclinicos.gov.br/rg/RBR-462vwq5	<NULL>	Individuals over 18 years of age; both genders; admitted to the General ICU of Hospital Universitário do Oeste do Paraná; patients on mechanical ventilation for the first 72 hours; with at least six teeth	Patients with severe maxillofacial trauma that made examination difficult; using complete dentures (upper and lower); pregnant women; immunosuppressed; using any anti-inflammatory and antibiotic for more than three days; serious medical or surgical complications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-553495p	Long-term clinical evaluation of composite resin restorations performed using BT Bioclear matrix system	Recruitment completed	Intervention	2023-11-28	<NULL>	<NULL>	6616	Influence of BT Bioclear matrix technique in the long-term quality of composite restorations. A double-blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-03	Universidade Federal Fluminense - Pólo de Nova Friburgo	Universidade Federal Fluminense - Pólo de Nova Friburgo	https://ensaiosclinicos.gov.br/rg/RBR-553495p	<NULL>	Participants from both gender; must be in good general health; be at least 18 years old; have an acceptable oral hygiene level; present at least 20 teeth under occlusion; have at least three black spaces to be restored in anterior teeth (these black spaces have to be non-retentive, with an average area higher than 1 mm2, and can involve only the enamel or both enamel and dentin, in vital teeth without mobility)	Patients with extremely poor oral hygiene or using orthodontic devices; severe or chronic periodontitis or with more than 10 teeth with occlusal facets (premolars and molars);  participants with known allergy to resin-based materials or any other material used in this study; pregnant or breastfeeding women; participants under chronic use of anti-inflammatory, analgesic, and psychotropic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-7yq9fh6	An Educational Intervention to Improve the Use of the Internet Regarding Health by adolescents	Recruitment completed	Intervention	2023-11-28	<NULL>	<NULL>	6617	An Educational Intervention to Improve Health-Related Internet use by adolescents: Randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal de Minas  Gerais	Universidade Federal de Minas  Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7yq9fh6	<NULL>	Adolescents between 13 and 18 years old with low levels of digital health literacy obtained by the Brazilian version of the eHeals questionnaire (Maschio, da Silva, 2019)	Adolescents who have any type of cognitive impairment; Adolescents who are not literate; Adolescents who do not have WhatsApp	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-937bj9r	Educational hypermedia for risk classification	Not yet recruiting	Intervention	2023-11-27	<NULL>	<NULL>	6610	Elaboration, validation and effects of educational software in embracement and obstetric risk classification	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Centro Universitário Inta	Centro Universitário Inta	https://ensaiosclinicos.gov.br/rg/RBR-937bj9r	<NULL>	Being a student regularly enrolled in the disciplines of Process of Care in Sexual and Reproductive Health (seventh semester) and Hospital Internship (ninth semester); Being regularly enrolled from the sixth semester; Being over 18 years old; Being attending the university during the period of data collection	Have previous practical experience in embracement and risk classification in obstetrics (students who carry out or have carried out extracurricular internships in this area)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-6whxxwc	Use of Turmeric to Improve Muscle Damage and Inflammation in Professional Soccer Athletes	Recruitment completed	Intervention	2023-11-27	<NULL>	<NULL>	6611	Effects of turmeric supplementation on markers of muscle damage and inflammation in professional soccer athletes: a randomized double-blind placebo-controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6whxxwc	<NULL>	All adult individuals; aged between 18 and 40 years; selected for the pre-season period at the time of the research	Individuals under 18 years of age; use of alcohol and/or illicit drugs; diagnoses of diagnosed inflammatory conditions; fibromyalgia; irritable bowel syndrome; use of supplements or anti-inflammatory drugs and/or antibiotics during the testing period or have an allergy/intolerance to turmeric.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-4wyfw3k	Rhinoplasty in patients with Cleft Lip Palate	Terminated	Intervention	2023-11-27	<NULL>	<NULL>	6612	Rhinoseptoplasty in Cleft Lip Palate patients, prospective evaluation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-05-17	Hospital das Clinicas da Faculdade de Medicina de São Paulo	Hospital das Clinicas da Faculdade de Medicina de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4wyfw3k	<NULL>	Patients of both sexes; aged between 16 and 60 years; with unilateral non-syndromic cleft lip; who have already undergone primary cheiloplasty using known techniques; alveolar bone grafting	Age under 16 years old or over 60 years old; bilateral cleft lip; previously submitted to secondary rhinoseptoplasty; and those who did not have treated cleft lip and palate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-37gx2f4	The effect of Interprofessional Clinical Simulation on the care of patients with Myocardial Infarction	Not yet recruiting	Intervention	2023-11-27	<NULL>	<NULL>	6613	Interprofessional Clinical Simulation as a teaching-learning strategy in the care of patients with Acute Coronary Syndrome: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-04-01	Universidade Federal de Santa Maria	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-37gx2f4	<NULL>	Being a nursing and medicine undergraduate student at the Pontifical Catholic University of Rio Grande do Sul (PUCRS); a technical nursing course at the Fundação Universitária de Cardiologia Professional School (FUC), who has completed the disciplines that address patient care with Acute Coronary Syndrome (ACS); regularly enrolled in these institutions; both genders	Students with total lockout at the time of data collection; on leave for health treatment; with certification from any technical or higher course in the health area, considering that they may have previous knowledge on the subject, thus favoring their performance in the simulated scenario	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-34d3jv2	Corneal injury treatment protocol using 50% Autologous Serum Eye Drops	Recruiting	Intervention	2023-11-27	<NULL>	<NULL>	6614	Interventional clinical protocol for assessing the therapeutic efficacy of 50% Autologous Serum Eye Drops in the treatment of corneal epithelial defects in Inflammatory ocular surface diseases	<NULL>	1-2, n/a, n/a	1-2	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-34d3jv2	<NULL>	Age 18 to 80 years. Both genders. Confirmed diagnosis of one of the following pathologies: Sjögren &apos;s syndrome, Moderate to severe non- Sjögren&apos;s dry eye, Stevens-Johnson syndrome, Graft versus host disease, Neurotrophic keratitis, Neurotrophic pain. Presence of corneal epithelial defect without improvement after treatment with preservative-free lubricating eye drops for at least 14 days. Absence of active infection on the ocular surface. No recent use of the following medications or performance of the following procedures: anticoagulants/ anti- platelet aggregation, blood product eye drops in the last 3 months, eye surgery in the last 6 months. Does not present any of the following conditions: poorly controlled systemic disease, active infection or advanced-stage cancer, pregnancy or breastfeeding. There are no contraindications to blood donation:  positive serology for HIV I and II or HTLV 1/2 or hepatitis B or hepatitis C or syphilis or Chagas disease according to Ordinance 158 of 02/04/2016 of the Ministry of Health – Brazil, anemia (hemoglobin level &lt; 11.0 mg/dl) or thrombocytopenia (platelet level &lt; 150 x 10 9 /L). Ability to adhere to the treatment and follow-up protocol during the study period and provide written consent for participation	Diagnosis of active corneal infection. Pregnancy diagnosed after beginning the protocol. Loss of clinical follow-up. Incorrect adherence to treatment, with application of less than 70% of the expected daily dose or remaining without use for more than one full day a week. Inadequate storage and care of eye drops. Need for other interventions to treat epithelial defect	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-4wsbmjf	Nutrition Education in Non-Alcoholic Liver Disease	Recruiting	Intervention	2023-11-24	<NULL>	<NULL>	6606	Nutritional Educational Intervention in Non-Alcoholic Fatty Liver Disease  (NAFLD)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-11	Universidade Federal do Paraná.	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4wsbmjf	<NULL>	Patients must be over 18 years of age; must not be significant drinkers; and this self-reported questioning is foreseen in the nutritionist consultation protocol. Alcohol consumption is considered significant if defined as &gt; 21 drinks per week in men and &gt; 14 drinks per week in women in a two-year period prior to baseline liver histology	Patients with positive serology for hepatitis B and C and HIV will be excluded from the study; patients with disabsorptive diseases (Chron&apos;s Disease, Celiac Disease); with chronic kidney disease; who are on the waiting list for bariatric surgery; pregnant and lactating women. People using steatogenic drugs or with hereditary liver diseases or who are not able to answer the nutritional literacy questionnaire with or without the help of the researcher or even patients who report frequent alcoholic intake will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-4q9jzrj	Evaluation of learning skills in videosurgery after training on simulator boxes	Recruitment completed	Intervention	2023-11-24	<NULL>	<NULL>	6607	Acquisition assessment of surgical skills through Videolaparoscopy training boxes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-02	Universidade Federal de Ciencias da Saude de Porto Alegre	Universidade Federal Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4q9jzrj	<NULL>	Students regularly enrolled in undergraduate medical courses at UFCSPA will be eligible for inclusion in the study	Individuals who are not attending an undergraduate course in medicine and who have not completed the steps will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-24m95ps	Effect of a Nutritional Program based on the degree of food processing on the metabolic control of individuals with Type 2 Diabetes Mellitus	Recruitment completed	Intervention	2023-11-24	<NULL>	<NULL>	6608	Evaluation of the Effectiveness of a Nutritional Intervention based on the degree of food processing for metabolic control of individuals with Type 2 Diabetes Mellitus assisted by primary health care in the state of Sergipe	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-15	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-24m95ps	<NULL>	Individuals with type 2 diabetes mellitus aged between 20 and 70 years, of both genders, assisted by Primary Health Care, from the Unified Health System (SUS) in the State of Sergipe, and who are users of the public health network residing in both urban and rural areas.	Individuals who are part of any group/study with an approach to food and nutritional education or other intervention, as well as pregnant women, patients using a feeding tube, patients who have undergone any surgical procedure in the last month, and patients with limiting factors for food intake due to their disease, such as head and neck cancer, HIV, and Chronic Obstructive Pulmonary Disease, will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-5tnzyc9	Home programs as intervention for babies with Down Syndrome: a feasibility study	Not yet recruiting	Intervention	2023-11-24	<NULL>	<NULL>	6609	Home programs for early intervention in Down Syndrome: a feasibility study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-15	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5tnzyc9	<NULL>	Children with Down Syndrome. Children util 3 years old.	Children with associated comorbidities as cerebral palsy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-4cvz58n	Evaluation of Periodontal Condition in Autistic Patients	Recruiting	Observational	2023-11-22	<NULL>	<NULL>	6599	Evaluation of Periodontal Conditions in Children with Autism Spectrum Disorder: Observational Cross-sectional Clinical Study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-05	Faculdade de Odontologia de Araçatuba FOA	Faculdade de Odontologia de Araçatuba FOA	https://ensaiosclinicos.gov.br/rg/RBR-4cvz58n	<NULL>	Patients diagnosed with Autism Spectrum Disorder (ASD) levels 1, 2 and 3; both sexes; in dental follow-up at the Dental Assistance Center for Persons with Disabilities (CAOE). In the case of Neurotypical individuals, the same inclusion criteria will be considered, with the exception of the diagnosis of ASD	Non-collaboration for dental treatment; unstable health condition; blood disorders; active cancer; supplemented with vitamins in the last two months; use of anti-inflammatory drugs or antibiotics in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-7rvw6cd	Transcranial Magnetic Stimulation as a Treatment for Primary Progressive Aphasia	Recruiting	Intervention	2023-11-22	<NULL>	<NULL>	6600	Case series: Transcranial Magnetic Stimulation for the treatment of patients with Primary Progressive Aphasia	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2023-07-31	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-7rvw6cd	<NULL>	Diagnosis of Aphasia,Primary Progressive - APP(logopenic, grammatical or semantic subtypes) based on clinical evaluation and speech-language pathology evaluation; be able to read, understand and sign the consent form to participate in the research;patients of both genders	Contraindication to Transcranial Magnetic Stimulation: history of epilepsy, traumatic brain injury, metal implant in the head; patients under judicial guardianship	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-6mb4b77	The effectiveness of Vitamin E in the treatment of wounds found in the mouth of patients admitted to the intensive care unit of a reference hospital in the state of Ceará	Recruitment completed	Intervention	2023-11-22	<NULL>	<NULL>	6601	The effectiveness of Vitamin E (Tocopherol) in the treatment of oral lesions found in intensive care unit patients in a reference hospital in the state of Ceará	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-02-15	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	Hospital de Messejana Dr. Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-6mb4b77	<NULL>	Individuals (American Society of Anesthesiologists) ASA II and III of both sexes; age between 30 and 65 years; having lesions in the oral cavity; admitted to intensive care units; and with injuries acquired during the hospitalization period	Volunteers with a confirmed history of allergy to tocopherol (Vit. E); pregnant or breastfeeding women; patients whose injury has its origins in the community, prior to hospitalization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-2ww2ts8	Effects of Electrical Stimulation in the head or ear region in adults with chronic stress	Data analysis completed	Intervention	2023-11-22	<NULL>	<NULL>	6602	Effects of Transcranial Direct Current Stimulation on the right and left dorsolateral prefrontal cortex or Non-Invasive Vagus Nerve Stimulation in adults with Chronic Stress	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2ww2ts8	<NULL>	Inclusion criteria consider individuals diagnosed with stress; Lipp adult stress symptom inventory score above 4; cognitive ability to read and interpret the purpose of the research and to respond to assessment instruments; and knowledge and consent of the free and informed consent form; Male or female volunteers aged between 20 and 50 will be recruited	Os critérios de exclusão são indivíduos fumantes; com história de tontura ou convulsão; gravidez; sinais de gravidade e/ou indicações de internação ou psicoterapia; uso de ansiolíticos; uso de antidepressivos; efeitos adversos detectados no grupo tratado com tDCS e taVNS, entre os quais coceira, formigamento, dor de cabeça, ardor, sensação e desconforto; diagnóstico de depressão; diagnóstico de ansiedade; transtorno de humor bipolar com sintomas depressivos, maníacos ou hipomaníacos no último ano; esquizofrenia ou outros transtornos psicóticos; autismo; dependência de substâncias; diagnóstico de epilepsia ou uso de anticonvulsivantes; contraindicações para a TDCS (implantes metálicos, tumor, cirurgias cerebral prévia, alteração anatômica cranioencefálica importante); contraindicações para a estimulação não invasiva do nervo vago (implante coclear, cirurgia plástica na orelha, má formação na orelha); iniciar e/ou intensidade de estimulação (mA), a largura de pulso (duração do pulso elétrico, ms), a frequência de pulso (Hz), e a relação on/off do ciclo de estímulo (medido em segundos ou minutos) são ajustados para otimizar a eficácia e tolerabilidade, porém ainda são um assunto a ser debatido.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-6ktm4zx	Application of laser to surgical wounds for breast cancer surgery	Not yet recruiting	Intervention	2023-11-22	<NULL>	<NULL>	6603	Photobiomodulation in operative wounds in breast surgery by Malignant Neoplasm	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-08	Universidade Federal de São Paulo - UNIFESP/EPM	Universidade Federal de São Paulo - UNIFESP/EPM	https://ensaiosclinicos.gov.br/rg/RBR-6ktm4zx	<NULL>	Patients over 18 years of age; diagnosed with any malignant neoplasm of the breast and who will undergo breast surgery	Patients diagnosed with benign breast neoplasia; diagnosed with bilateral malignant neoplasm; diagnostic sectorectomy; musculocutaneous flap; inflammatory T4B staging due to dermal infiltration; with tattoo or hematoma in approximately 30% of the extent of the surgical wound	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-3c5qvtt	Physical therapy using manual techniques in individuals with Chronic Migraine: impact on treatment self-efficacy, disability, sleep quality and quality of life	Recruitment completed	Intervention	2023-11-22	<NULL>	<NULL>	6604	Manual Therapy in patients with Chronic Migraine: impact on management self-efficacy, disability, sleep quality and quality of life	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Delta do Parnaíba - UFDPar	Universidade Federal do Delta do Parnaíba - UFDPar	https://ensaiosclinicos.gov.br/rg/RBR-3c5qvtt	<NULL>	Individuals between 18 and 59 years of age; of both genders; with chronic migraine diagnosed by the reference headache neurologist of the Integrated Center for Medical Specialties (CIEM) according to the criteria of the International Classification of Headache Diagnosis (ICHD-3); in clinical follow-up for at least three months and who present symptoms for more than 12 months	Individuals with contraindications for manual therapy, including inflammatory disorders, severe osteoporosis, tumors and those with signs of impairment of the vertebral artery and internal carotid artery; individuals with temporomandibular disorders; decompensated blood pressure; diagnosed with systemic diseases; pregnant and lactating women; individuals with neurological deficit and/or cognitive alterations; those who do or have had manual therapy in the last three months; individuals whose migraine symptoms started after the age of 50; those with neck stiffness with or without fever; those who reported worsening of pain with postural change or valsing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-22ssh2j	Effect of combined Pelvic and Respiratory Muscle Training in women with Urinary Incontinence and COPD	Recruiting	Intervention	2023-11-22	<NULL>	<NULL>	6605	Effect of the association of Training on the Pelvic Floor Muscles and Inspiratory Muscles in women with Stress Urinary Incontinence due to COPD: randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-07	Universidade Federal Delta do Parnaíba	Universidade Federal Delta do Parnaíba	https://ensaiosclinicos.gov.br/rg/RBR-22ssh2j	<NULL>	The research will include women from 50 to 70 years old in the city of Parnaíba;  proven clinical diagnosis of COPD (Chronic Obstructive Pulmonary Disease) and urinary incontinence by urodynamics; in addition to presenting good cognitive and verbal conditions; who agreed to participate in the research after reading understanding and signing the Informed Consent Term	Will be excluded from the research volunteers with unstable Chronic Obstructive Pulmonary Disease; with more than four hospital admissions for COPD (Chronic Obstructive Pulmonary Disease)  in the current year; some previous gynecological surgical process; those with low cognition or Mini Mental State Examination score below 19 points for illiterates and below 22 for literate women as recommended by the Ministry of Health	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-10jzgw6h	Infrared laser treatment of the cervical region in patients with chronic shoulder pain	Recruiting	Intervention	2023-11-21	<NULL>	<NULL>	6593	Addition of photobiomodulation in the cervical region in patients with chronic shoulder pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade Federal de São Paulo - UNIFESP	Departamento de Ciências do Movimento Humano da universidade federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10jzgw6h	<NULL>	shoulder chronic pain unilateral and bilateral which six months; pain intensity more than 5 points in NRS, age between 25 and 60 years old.	peripheral inflammatories conditions such as rheumatology disease; neurological injuries which affect the perception of pain; shoulder injuries with ROM important restrictions; pregnancy; previous shoulder surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-9yrfyfq	Acute Effects of Respiratory and Resistance Training with Blood Flow Restriction on respiratory, hemodynamic variables and peripheral muscle strength in subjects with COPD	Recruiting	Intervention	2023-11-21	<NULL>	<NULL>	6594	Acute Effects of Respiratory and Resistance Training with Blood Flow Restriction on respiratory, hemodynamic variables and peripheral muscle strength in subjects with COPD	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-19	Centro de Ciências da Saúde - Universidade Federal da Paraíba	Centro de Ciências da Saúde - Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9yrfyfq	<NULL>	Diagnosis of mild, moderate or severe Chronic Obstructive Pulmonary Disease (COPD), that is, presenting a Forced Expiratory Volume in the first second (FEV₁) after bronchodilator between 30% and ≥ 80% of the predicted value; age over 60; both genders; absence of locomotor or neurological comorbidities that prevent the performance of tests and exercises; no exacerbation of symptoms and stable pharmacological regimen for at least two months before the start of training; who voluntarily accept to participate in the research by signing the Free and Informed Consent Form (TCLE)	Present during the experiment any cardiovascular and musculoskeletal aggravating factors that prevent treatment from being carried out; no carry out at least 85% of treatment sessions, or; withdraw from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-3h38cww	Lullaby in reducing pain in newborns	Recruiting	Intervention	2023-11-21	<NULL>	<NULL>	6595	Lullaby in reducing pain associated with heel puncture in neonatal biological screening: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Piauí - Campus Amílcar Ferreira Sobral	Universidade Federal do Piauí - Campus Amílcar Ferreira Sobral	https://ensaiosclinicos.gov.br/rg/RBR-3h38cww	<NULL>	Newborns with gestational age (GA) ≥ 37 weeks; age from three to 28 days; birth weight ≥ 2,500 g, considering that full-term babies have a different perception of pain than preterm newborns	Newborns who are receiving antibiotics, steroids or analgesics (up to 3 hours before the interventions); sick from any cause; neonates with medical instability; and NB accompanied by caregivers other than the mother. Finally, discontinuity criteria will be: NB who receive heel puncture twice due to an unsuccessful first procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-4kf52bv	Analysis of motor performance after performing Telerehabilitation with virtual reality games in people with Cerebral Palsy	Recruitment completed	Intervention	2023-11-21	<NULL>	<NULL>	6596	Analysis of motor performance after performing Telerehabilitation with virtual reality games in people with Cerebral Palsy	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-01-19	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4kf52bv	<NULL>	Clinical diagnosis of Cerebral Palsy; classified in Gross Motor Function (GMFCS) between levels I to V; classified in Manual Function (MACS) between levels I to V; age ranging from 5 to 40 years, of any muscle tone	Those who do not understand the tasks of the game; have motor difficulties that prevent the performance of virtual tasks; surgery or use of an upper limb spasticity inhibitor during the last six months; do not have technology devices to perform telerehabilitation; impediment of complete the task due to some technological glitch	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-108mccss	Evaluation of use of tissue adhesive in surgeries of wisdom tooth	Recruitment completed	Intervention	2023-11-21	<NULL>	<NULL>	6597	Evaluation of the use of 2-octyl cyanoacrylate (Dermabond®) adhesive in the closure of the surgical wound in surgery of mandibular third molars	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-10	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-108mccss	<NULL>	Adult individuals of both sexes; Presence of bilateral mandibular third molars in similar positions, according to Winter&apos;s classification; Agree to participate in the study	Allergy to any component of Dermabond®; Patients using medications that may interfere with healing (antiplatelet agents, anticoagulants, immunosuppressants, corticoids); Smoking patients; Patients with uncontrolled systemic alterations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-759vsh4	Effects of a virtual game on television on elderly people living in a nursing home	Recruitment completed	Intervention	2023-11-21	<NULL>	<NULL>	6598	Effects of Virtual Reality on institutionalized elderly people: quasi-experimental study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-14	Centro Universitário Presidente Tancredo de Almeida Neves	Centro Universitário Presidente Tancredo de Almeida Neves	https://ensaiosclinicos.gov.br/rg/RBR-759vsh4	<NULL>	Elderly people aged 60 or over; of both sexes; living in a long-term care facility	Bedridden; wheelchair users; who use walking aids; history of acute and chronic physical, cognitive and mental illnesses that may make exercise difficult; who have hearing and vision problems that make it difficult to perform exercise; who present in the Mini State Examination Mental scores lower than 13 points for illiterates, 18 points for low and medium schooling and 26 points for high schooling; who present any conditions that make it impossible for them to carry out the proposed procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:49
RBR-10zfhxvy	Clinical analysis of Zirconia and Titanium dental implants placed in Maxilla and Mandible	Recruiting	Intervention	2023-11-20	<NULL>	<NULL>	6588	Clinical analysis of Zirconia and Titanium dental implants placed in Maxilla and Mandible. A split-mouth randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Odontologia de Araraquara- Universidade Estadual Paulista	Instituto Latino Americano de Pesquisa e Ensino Odontológico	https://ensaiosclinicos.gov.br/rg/RBR-10zfhxvy	<NULL>	Need for bilateral single-tooth rehabilitation with osseointegrated implants in the maxilla or mandible; sufficient bone availability for installation of conventional-sized implants; good systemic health	Smokers and ex-smokers; diabetics; participants who are chronic users of medications (eg. Bisphosphonates, immunosuppressants, anti-inflammatories) or pathologies that alter bone metabolism (eg. Osteoporosis; Diabetes; participants who chronically use anti-inflammatories and antibiotics; bruxism sufferers; alcoholics; drug addicts; pregnant or wishing to become pregnant in the next year; history of radiotherapy treatment in the head and neck region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-6p6t4br	The Effect of Osteopathy on Women with Chronic Pelvic Pain	Recruitment completed	Intervention	2023-11-20	<NULL>	<NULL>	6589	Effectiveness of Osteopathic Manipulative Treatment in Women with Chronic Pelvic Pain: Single-Blind Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Mestrado Profissional Saúde Materno Infantil	Mestrado Profissional Saúde Materno Infantil	https://ensaiosclinicos.gov.br/rg/RBR-6p6t4br	<NULL>	Women between 18 and 50 years old; diagnosed with Chronic Pelvic Pain for at least 6 months; with Visual Analogue Pain Scale equal to or greater than 4	Women with recent trauma; diagnosis of other acute diseases (pelvic inflammatory disease, twisted adnexal cyst, diverticulitis); pregnancy and previous urogenital malignancy; cancer; psychiatric disorders and cognitive impairment or who have undergone physiotherapeutic or osteopathic treatment in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-2fvknfd	Stability of printed versus conventional retainers: randomized clinical trial	Not yet recruiting	Intervention	2023-11-20	<NULL>	<NULL>	6591	Stability of 3x3 digital printed versus conventional retainers: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-01-20	Faculdade de odontologia de Bauru - Universidade de São Paulo	Faculdade de odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2fvknfd	<NULL>	Volunteers in the final phase of orthodontic treatment; of both sexes; in the permanent denture phase; with erupted second molars; all dental elements present without changes in shape or number; adequate correction of malocclusion and alignment of dental elements; good collaboration and oral hygiene	Volunteer who had complex initial malocclusions that required large transverse expansions and/or orthognathic surgery; poor oral hygiene; history of periodontal disease or systemic conditions that may influence periodontal health; any type of condition that makes it impossible to carry out clinical care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-296drgz	Effects of deep relaxation on pain in patients with chronic wounds	Not yet recruiting	Intervention	2023-11-20	<NULL>	<NULL>	6592	Effects of Hypnosis on pain: a clinical trial in patients with chronic wounds	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-30	Universidade do Estado da Bahia	Secretaria Municipal de Saúde de Salvador	https://ensaiosclinicos.gov.br/rg/RBR-296drgz	<NULL>	Being 18 years of age or older; both genders; have a wound that has existed for four weeks or more, and complain of moderate to severe pain	Patients with altered hearing acuity;  patients with disorientation in time and space	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-6q5299j	Effectiveness of a Sensorimotor Exercise Program in the sensation of joint position, balance, muscle strength, independence to move and risk of falls in the elderly	Recruitment completed	Intervention	2023-11-18	<NULL>	<NULL>	6587	Effectiveness of a Sensorimotor Exercise Program on proprioception, balance, muscle strength, functional mobility and risk of falls in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade Fernando Pessoa	Universidade Fernando Pessoa	https://ensaiosclinicos.gov.br/rg/RBR-6q5299j	<NULL>	institutionalized elderly people over 70 years of age who were undergoing regular medical monitoring; medical indication for motor physiotherapy; physical autonomy when leaving bed and who were not performing physical activity regularly; ability to make decisions	elderly people with physical independence restricted to bed; wheelchair users or those who were not physically capable of walking and hemodynamic instability; severe heart disease or uncontrolled systemic arterial hypertension verified by the doctor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-5ddt474	Effects of an intervention program in patients with swallowing difficulties and Parkinson&apos;s	Recruiting	Intervention	2023-11-17	<NULL>	<NULL>	6582	Effects of an intervention program in dysphagic patients with dysphagia Parkinson&apos;s	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal do Rio Grande do Norte	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-5ddt474	<NULL>	Adults treated at the Hospital Universitário Onofre Lopes (HUOL); aged &gt;18 years; of both genders; diagnosed with Parkinson&apos;s; complaining of oropharyngeal dysphagia; who had not previously undergone speech therapy	Patients with coexistence of other neurological diseases; with head and neck cancer; tracheostomy users; using an alternative feeding route; those who are unable to follow commands	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-2g463ss	Effect of Nursing Consultation based on Orem&apos;s model in self-care agency and adherence to treatment of elderly people with HIV	Recruitment completed	Intervention	2023-11-17	<NULL>	<NULL>	6583	Effect of nursing consultation based on the Orem model on health parameters in people with neurocognitive changes associated with HIV/AIDS	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-05	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-2g463ss	<NULL>	Patients aged 50 years or older treated at the infectology outpatient clinic for at least 6 months	Patients with some physical or mental disability and patients who do not attend the next stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-9y296bt	Effect of Neuromuscular Electrical Stimulation of the Quadriceps on Pain and Functional Physique of Elderly Women with Knee Osteoarthritis Feasibility Study	Recruitment completed	Intervention	2023-11-17	<NULL>	<NULL>	6584	Effect of Neuromuscular Electrical Stimulation of the Quadriceps on Pain and Functional Physique of Elderly Women with Knee Osteoarthritis Feasibility Study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-20	Universidade Federal do Amazonas	Associação do Idosos do coroado (ASSIC)	https://ensaiosclinicos.gov.br/rg/RBR-9y296bt	<NULL>	age between 60 and 79 years old; diagnosis of knee osteoarthritis by a medical doctor; with history, physical examination and radiographic findings; Radiography in the last 12 months showing grade 2 or 3 osteoarthritis (OA) based on radiographic classification	use of a pacemaker and unstable heart conditions (coronary artery disease, valvular heart disease, cardiomyopathy, myocarditis); neurological or cognitive disorders; participation in another physical activity program in addition to the activities of the Associação de Idosos do Coroado (Assic) or physiotherapeutic treatment in the last 3 months; not being able to walk without assistance; skin lesion at the site of application of neuromuscular electrical stimulation; have contraindications clinically determined by a medical doctor to participate in the experiment; previous musculoskeletal surgery or joint injuries other than knee osteoarthritis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-5gkdn2r	Acute effect of low-intensity aerobic exercise with blood flow restriction on motor learning	Recruitment completed	Intervention	2023-11-17	<NULL>	<NULL>	6585	Aerobic exercise and motor learning: Does blood flow restriction induce increased effects?	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-10	Universidade Estadual do Piauí	Universidade Estadual do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-5gkdn2r	<NULL>	Be aged between 18 and 50 years old. Both genders. Be right-handed. Be a higher education student, regardless of semester. Have sufficient neuromotor and cognitive conditions to understand and perform the proposed tasks. Have a medical report allowing the practice of physical activity, especially those related to blood flow restriction exercise protocol. Use corrective lenses in case the participant has visual acuity. Sign the Informed Consent Form	Have cardiovascular diseases, a history of thrombosis, respiratory diseases, diabetes mellitus, obesity, or any other medical condition that would prevent the execution of the proposed activities, especially those related to the blood flow restriction exercise protocol. Do not have a medical report indicating any risk in engaging in physical activity, especially related to the blood flow restriction exercise protocol. Have osteoarticular impairments that prevent the execution of the task or may be aggravated due to the proposed practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-3cb6qtz	Acute Cajuína (Anacardium occidentale L.) intake does not improve Leukocyte count, Lipid peroxidation, and Physical performance in Runners: a double-blind, crossover, randomized, placebo-controlled clinical trial.	Data analysis completed	Intervention	2023-11-17	<NULL>	<NULL>	6586	Effects of Cajuína on biochemical, physiological, and cognitive markers in Runners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-12	Universidade Estadual Vale do Acaraú	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3cb6qtz	<NULL>	absence of any health-related conditions; no use of nutritional supplements for at least three months, including the duration of the study; non-smokers or drinkers; participation in national and state competitions in recent months; ability to complete a 10-km run in less than 60 minutes	consumers of cashew juice, cajuína, or any other product containing polyphenols such as grape, red wine, and cocoa; myotendinous injury during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-78fhyrf	Heart Response during Handgrip Exercise	Recruiting	Intervention	2023-11-17	<NULL>	<NULL>	6864	Handgrip Cardiovascular Response	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-18	Escola Bahiana de Medicina e Saúde Pública	Escola Bahiana de Medicina e Saúde Pública	https://ensaiosclinicos.gov.br/rg/RBR-78fhyrf	<NULL>	Healthy volunteers; male; age between 18 and 30 years; within the ideal weight; physically active or not active	History of cardiovascular or respiratory disease; smokers; high-risk classification for cardiovascular disease, with two or more risk factors, according to the guidelines for stress testing and its prescription from the American college of sports medicine; drug abuse; pre-existing musculoskeletal disorders or neurological, renal, hepatic, gastrointestinal, psychiatric, hematological or metabolic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-4h8z5js	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Not yet recruiting	Intervention	2023-11-16	<NULL>	<NULL>	6576	Evaluation of the gynecological and dermatological acceptability of an intimate fluid for health under normal conditions of use_INT01.2023	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-14	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Intt Comercio, Distribuição, Importação e Exportação de Cosmeticos LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4h8z5js	<NULL>	Women; age 18 to 59 years; phototype I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; pregnant or lactating women; participants with a history of allergy to the material used in the study; atopy history; use of vaginal cream; participants with a history of allergy to products in the tested category; recent gynecological surgeries; discharges; immunodeficiency carriers; kidney, heart or liver transplants; active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); topical use with corticosteroids in the experimental area up to 8 days before the start of the study; any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-76dknt8	Effect of Ozonated Oil as a Desensitizer Prior to In-Office Dental Bleaching – Clinical, Randomized, Blind Study	Recruitment completed	Intervention	2023-11-16	<NULL>	<NULL>	6578	Influence of different Desensitizing Protocols on Sensitivity control after Tooth Bleaching: clinical, blinded and randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-20	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-76dknt8	<NULL>	Patients of both sexes; age between 18 and 35 years; presence of all vital anterior teeth; never bleached or restored; have central incisors of A2 color or darker	Patients with missing anterior teeth; affected by caries lesions; presence of recession; some type of restorative or prosthetic treatment; had a history of dental hypersensitivity; had tooth discoloration by tetracycline or flourose; they used many medications; who fit the status of pregnant or lactating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-7hqhj3y	"Use of calcium carbonate supplementation to prevent Pre-eclampsia in pregnant women high risk:
randomized clinical trial"	Not yet recruiting	Intervention	2023-11-16	<NULL>	<NULL>	6581	Use of calcium carbonate supplementation to prevent Pre-eclampsia in pregnant women high risk: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-10	Centro de Ciências Biológicas e da Saúde - Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7hqhj3y	<NULL>	Pregnant women who are up to the 20th week of pregnancy at the first stage of the approach; minumium age of 15 years; who present one or more of the risk factors: history of pre-eclampsia, multiple pregnancy, chronic hypertension, type 1 or 2 diabetes, autoimmune disorder) will be included in the study. , kidney disease, nulliparity, body mass index &gt;30 kg/m2, family history of preeclampsia (first-degree relative), sociodemographic characteristics (African American, low socioeconomic status), age &gt;35 years, history factors (pre-low birth weight or small birth for gestational age, previous adverse pregnancy outcome, interval &gt;10 years since previous pregnancy, term birth without previous complications) for the occurrence of pre-eclampsia; and/or low intake of calcium	Pregnant women with known placental abnormalities; current pregnancy as a result of in vitro fertilization; regular use of platelet-active drugs; known fetal abnormalities; uterine bleeding documented within one week of screening; uterine malformations; pregnant women with chronic systemic hypertension; sickle cell anemia; those under 15 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-6g85ff9	Effects of Elastic Bandage in the postoperative of breast Cancer Surgeries	Recruitment completed	Intervention	2023-11-16	<NULL>	<NULL>	8414	Effects of Taping&apos;s application in the immediate post-operative after breast Reconstructive Surgery: Randomized Clinical Trial - BREASTAPING I	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2023-06-01	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6g85ff9	<NULL>	be female; be between 20 and 70 years of age; having been diagnosed with breast cancer; have indication for surgical treatment of oncoplastic or breast reconstructive surgery.	have an allergy to the taping tape; present psychological or cognitive disorders that prevent understanding of the research and assessment instruments; participants who develop infections, hemorrhages, bruises or other complications in the P.O. will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:55
RBR-8ghk566	Changes in nasal obstruction in adolescents with allergic rhinitis after laser use	Recruitment completed	Intervention	2023-11-15	<NULL>	<NULL>	6574	Effects of photobiostimulation with red and infrared laser on nasal obstruction in adolescents with allergic rhinitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Escola Paulista de Medicina	Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-8ghk566	<NULL>	Age between 8 and 17 years old, medical diagnosis of RA (ARIA) present in the medical record for at least 12 months; allergic sensitization by immediate reading skin test (Prick test) or specific serum IgE to at least one inhaled allergen in the last 12 months; degree of nasal obstruction with values equal to five on the day of the test on a visual analogue scale (5 to 10).	Severe or uncontrolled asthma; use of topical medication (nasal decongestant in the last 24 hours); topical corticosteroids within two weeks; use of oral medication: systemic corticosteroids within the last four weeks,chromones within d weeks, antihistamines within a week or immunotherapy five years before the start of the study; severe systemic disease; history or signs of upper or lower respiratory infection within the last four weeks; anatomical defects of the upper airways (nasal polyposis, adenoid hypertrophy, deviated septum, tumor mass) documented in the medical record or observed on physical examination; maxillary atresia; history of epistaxis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-6bckd5p	Evaluation of the use of Camphora 1M in Covid-19 complications in municipalities of Santa Catarina	Recruitment completed	Observational	2023-11-15	<NULL>	<NULL>	6575	Evaluation of the use of Camphora 1M (homeopathic medicine) in the prevalence of Covid-19 complications municipalities of Santa Catarina	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-10-21	Edgard Costa de Vilhena	UNIP Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6bckd5p	<NULL>	In Ecologic studies we analyse Municipalities that have effectively adopted the mass distribution of Camphora 1M by June 30, 2020. Not people especificaly we analyse hospitalizations. Control municipalities, with similar demographic characteristics, chosen by comparing these variables, according to the protocol described	Municipalities dissimilar to the adhering municipalities regarding the assumptions described in the predictor variables	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-888hg2v	Effect of Reiki on the anxiety of Nurses working in Intensive Care Units	Recruitment completed	Intervention	2023-11-14	<NULL>	<NULL>	6572	Effects Reiki on Anxiety of Intensive Care Nurses	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-07	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-888hg2v	<NULL>	Nurses of both sexes who report or refer to feeling anxious during the interview will be included; those who have some degree of anxiety evidenced by IDATE and nurses with at least 1 year of experience in the ICU will also be included; the nurse will be included in the research regardless of the use of psychotropic medications and psychological support, so that our research does not interfere with their treatment	Professionals who have been away for more than six consecutive months in the last year; professionals who are on vacation or away during the execution of the research and participants who, through self-report, have a mental disorder, other than anxiety, will be excluded, according to sociodemographic instrument	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-2mg6m6k	Use of Intraneural Catheter for prevention of Pain and the development of Phantom Limb Syndrome in oncological Amputations	Recruiting	Intervention	2023-11-14	<NULL>	<NULL>	6573	Use of Epineural Catheter for prophylaxis of Pain and development of Phantom Limb Syndrome in oncological Amputations	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-15	Instituto Nacional de Ortopedia e Traumatologia Jamil Haddad	Instituto Nacional de Ortopedia e Traumatologia Jamil Haddad	https://ensaiosclinicos.gov.br/rg/RBR-2mg6m6k	<NULL>	Amputation of lower limbs; bone tumors; over five years old; both sexes.	No multidisciplinary monitoring before amputation; no use of pregabalin, gabapentin or amitriptyline for 15 days before amputation; adverse reaction to catheter medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-32592zd	Randomized comparative study of double J catheter with reduced tip vs conventional double J catheter (normal tip)	Not yet recruiting	Intervention	2023-11-13	<NULL>	<NULL>	6570	Randomized comparative study of customized double J loop catheter X convencional double J catheter	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Irmandade da Santa Casa de Misericórdia de Santos	Irmandade da Santa Casa de Misericórdia de Santos	https://ensaiosclinicos.gov.br/rg/RBR-32592zd	<NULL>	Patients of both genders; at least 18 years old; indicated for a double J catheter, regardless of the study; who understand and accept informed consent	Patients who do not agree to participate; those under 18 years of age; those with a urinary catheter at the time of the intervention or less than 6 months ago; those with neurological diseases or those using antidepressants; bilateral catheters; those with malignant disease; active infection; ureter injury greater than 2 on the Traxer scale; antegrade double J; patients with chronic pain and pelvic radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-109bgw4z	Meditation practice as a way of improving the quality of life of children&apos;s teachers and its consequences for students	Recruitment completed	Intervention	2023-11-13	<NULL>	<NULL>	6571	Mindfulness as a tool for improving quality of life life of early childhood educators and its consequences for students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Faculdade de Ciências Médicas de Minas Gerais	Universidade Federal de Minas Gerais - UFMG	https://ensaiosclinicos.gov.br/rg/RBR-109bgw4z	<NULL>	Teacher of students from 6 months to 5 years of age; in one of the 14 daycare centers in Belo Horizonte selected for the study; both genders	Early childhood educators who did not have their own class or who are teachers of pupils under 6 months or over 5 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-23pc36b	The effect of recovery time after prior application of Blood flow restriction on the neuromuscular performance of basketball athletes	Recruitment completed	Intervention	2023-11-11	<NULL>	<NULL>	6569	The effect of recovery time after Ischemic preconditioning on the neuromuscular performance of basketball athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-12	Universidade Federal da Paraíba	Centro de Ciência da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-23pc36b	<NULL>	basketball athletes, with regional or national competitive level;aged between 16 and 23 years;male;with a minimum of 6 months of basketball experience; and who present Ankle Brachial Index (ABI) values between 0.90 and 1.30	symptoms or osteo-myarticulary injuries that interfere with the execution of exercises; not completing at least 85% of the training sessions; missing any of the assessments; and withdrawing from participating in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-7d3yxz3	Effects of the Vibrating Platform on Nerve Injury caused by chemotherapy	Not yet recruiting	Intervention	2023-11-10	<NULL>	<NULL>	6567	Effects of Whole Body Vibration in chemotherapy periphery induced Neuropathy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-30	Hospital do Cancer II	Hospital do Cancer II	https://ensaiosclinicos.gov.br/rg/RBR-7d3yxz3	<NULL>	protocol of carboplatin associated with paclitaxel at a high dose; curative intent;  ovarian cancer; endometrial cancers	previous chemotherapy treatment; pre-existing neuropathy; metastases unstable bone fractures; cardiac pacemaker; lower limb surgeries in the last year; presence of metallic prostheses; deep venous thrombosis for less than 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-5j9k359	Effect of Cooking Oils on Overweight women’s health	Recruitment completed	Intervention	2023-11-10	<NULL>	<NULL>	6568	Effect of Vegetable Oils consumption on obesity-related metabolic markers in women with Excess Body Fat	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-03	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5j9k359	<NULL>	Women; aged between 20 and 41 years; linked at the Universidade Federal de Viçosa; body mass index between 26 and 34.9 kilograms per square meter; body fat percentage above 30; level of food inhibition/disinhibition less than or equal to 14	Smokers; pregnant women; lactating women; women with menstrual irregularities in the last three months; elite athletes; habitual consumption of olive oil or coconut oil; changes in physical activity level and body weight of more than 5 kilos in the last three months; vegetarians; alcoholics; use of supplements or medication; presence of food allergies or intolerances or aversion to the ingredients tested; gastrointestinal diseases; chronic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-95vw7sj	Effect of Aerobic Exercise on Anxiety level in healthy individuals	Not yet recruiting	Intervention	2023-11-08	<NULL>	<NULL>	6566	Comparison of the acute effect of Aerobic Exercise performed at different intensities on State Anxiety level in healthy individuals exposed to anxiogenic stimuli	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-06	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-95vw7sj	<NULL>	Both gender; aged between 18 and 40 years old; be literate	Be in the menstrual period (applicable for women); use psychotropic drugs;have restrictions to perform physical exercise (determined by the Physical Activity Readiness Questionnaire); have a diagnosis of anxiety disorder and/or depression; being in the gestational period (applicable to women)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-28czd8q	Evaluation of surgical outcomes of patients treated with the Surgery Protocol Before the Orthodontic treatment	Recruitment completed	Intervention	2023-11-07	<NULL>	<NULL>	6565	Evaluation of surgical outcomes of patients treated with the Surgery First Approach and Aligners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-10	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-28czd8q	<NULL>	Adults; Skeletal malocclusion; ANB (cephalometric analysis widely used in Orthodontics) zero or negative; Witts negative; Mandibular excess, a maxillary deficiency, or a combination of both; Indication for bimaxillary surgery	Previous orthodontic treatment; Craniofacial anomaly or previous fracture of the facial bones; Total edentulism; Deep curve of Spee; Vertical asymmetry; Any medication use that contraindicates surgical treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-7phn8yv	Efficacy of analgesics in controlling pain associated with the insertion of a Copper or Hormone Intrauterine Device	Not yet recruiting	Intervention	2023-11-06	<NULL>	<NULL>	6564	Double-blind clinical trial, phase IV, prospective, national, single-center, randomized, to evaluate the efficacy of prophylactic administration of DEC103 compared to placebo in controlling pain associated with the insertion of a Copper Intrauterine Device (TCu380A IUD) or Intrauterine System with Levonorgestrel (LNG-IUS) 52 mg - DEC103-IV0123	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-11-13	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	Hospital da Mulher Professor Doutor José Aristodemo Pinotti - Centro de Atenção Integral à Saúde da Mulher - CAISM/ Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-7phn8yv	<NULL>	Women; with ability to confirm voluntary participation and agree to all the purposes of the trial by signing and dating the Informed Consent Form; age between 18 and 49; participants who will undergo the TCu380A Intrauterine Device (IUD) or LNG 52mg Intrauterine Device (IUD) insertion procedure for the first time; nulliparous women	Any clinical observation finding (clinical/physical evaluation) or laboratory condition that is interpreted by the investigating physician as a risk to the research participant&apos;s participation in the clinical trial or presence of uncontrolled chronic disease; chronic pelvic pain of any etiology; abnormality in the uterine cavity; psychiatric disorders; chronic use of medications that interfere with the pain threshold, e.g.: antidepressants and anticonvulsants; use of analgesics and/or anti-inflammatory drugs in the last 24 hours before the procedure; signs and/or symptoms of vaginal and/or cervical infection; contraindication to the use of Trometamol Ketorolac 10 mg, or Dipyrone Monohydrate + Scopolamine Butylbromide + Hyoscyamine Hydrobromide + Homatropine Methylbromide, 300 mg + 6.5 mcg + 104 mcg + 1mg; current alcohol or illicit drug use disorder; breastfeeding; participants with known allergy or hypersensitivity to the components of the drugs; participants with a current medical history of cancer and/or treatment for cancer in the last 5 years; participated in clinical trial protocols in the last 12 (twelve) months (CNS Resolution 251, of August 7, 1997, item III, sub-item J), unless the investigator judges that there may be a direct benefit to the investigator	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-72mfkv8	Analyzing the relationship between total sleep time in patients undergoing Orthopedic Rehabilitation	Recruiting	Observational	2023-11-04	<NULL>	<NULL>	6563	Relationship of total sleep time in the Rehabilitation of orthopedic patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-21	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-72mfkv8	<NULL>	Patients of both genders. Adults aged 30 to 59 years. With musculoskeletal injuries (hip and knee). With a Body Mass Index of normal (18.5-24.9 kg/m 2 ) to overweight (24.9- 30kg/m2). Patients who had sleep disorders and/or insomnia. Patients who voluntarily agree to participate in the study and sign an informed consent form. Patients who are able to fulfill study requirements, such as keeping a sleep diary and regularly participating in rehabilitation sessions	Patients with a history of serious psychiatric disorders such as schizophrenia or bipolar disorder. Patients with severe neurological disorders such as Cerebrovascular Accident (CVA) or spinal cord injury. Patients with serious chronic illnesses such as Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF). Patients who are using medications that affect sleep, such as benzodiazepines or antipsychotics. Patients who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-3578vwr	Cupping therapy for neck pain and disability	Recruiting	Intervention	2023-11-04	<NULL>	<NULL>	7368	Cupping therapy for neck pain and disability	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-06	Universidade Federal de Pernambuco	Departamento de Fisioterapia da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3578vwr	<NULL>	Visual Analogue Scale (VAS) greater than or equal to 3 points; Neck Disability Index (NDI) greater than or equal to 13 points	Pregnant or lactating women; patients who use anticoagulants; anemia; use of opioid analgesics (examples: Morphine, Tramadol, Hydromorphone, Fentanyl, and others) at the time of data collection or up to three months prior; patients presenting red flags (vertebral fracture, vertebral tumor, vertebral infection; systemic diseases (autoimmune, infectious, vascular insufficiency, renal insufficiency, hepatic insufficiency, neoplasia); fibromyalgia; cervical disc herniation; previous spine surgery; patients with open or poorly healing wounds in the cervical region; cervical brachialgia; alteration of skin integrity and people who have been previously treated with cupping therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-10sghzys	Use of low-power laser to control pain and discomfort due to the use of mini-implants: a clinical research	Not yet recruiting	Intervention	2023-11-03	<NULL>	<NULL>	6560	Use of low-level laser therapy to control pain and discomfort resulting from skeletal anchorage with miniscrews: a triple-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	karine cestaro mesquita	Centro Universitário Christus	https://ensaiosclinicos.gov.br/rg/RBR-10sghzys	<NULL>	healthy volunteers; both genders; between 18 and 55 years old; showing the need for lateral distalization of the teeth based on the use of an orthodontic mini-implant	Patients with systemic and/or oral diseases; Use of anti-inflammatory medication or antibiotics in the last 24 months and chronic consumption of alcohol or tobacco, or history of installation and/or previous rejection of mini-implants; who did not have uncontrolled periodontal disease; patients with no history of radiotherapy, or using medication with bisphosphonates.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-7ctn7pp	Comparison of the use of different volumes of Nasal Irrigation Solution in postoperative period of Nasal Endoscopic Surgery in patients with Chronic Sinusitis with Nasal Polyps	Recruiting	Intervention	2023-11-03	<NULL>	<NULL>	6561	Comparison of the use of different volumes of Saline Solution with Corticosteroids in postoperative period of Nasal Endoscopic Surgery in patients with Chronic Rhinosinusitis with Nasal Polyps	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7ctn7pp	<NULL>	We will evaluate patients in the immediate postoperative period of nasal endoscopic surgery due to Chronic Rhinossinusitis with Nasal Polyps. Patients aged 18 to 70 years who have bilateral disease and who have undergone at least anterior and posterior ethmoidectomy and bilateral maxillary antrostomy will be included	Patients with suspected systemic diseases with nasal involvement, such as cystic fibrosis and ciliary dyskinesia. Patients with exacerbations at the time of the surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5g75r5s	Encouraging healthy eating among elementary school pupils by making changes in the school environment	Data analysis completed	Intervention	2023-11-03	<NULL>	<NULL>	6562	Promoting healthy eating in elementary school children using Architecture of Choices and Cooking Workshop strategies	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5g75r5s	<NULL>	Literate students; age between 7 and 12 years; students with signature of the Informed Consent Form by the guardians; signature of the Consent Form by the student.	Non-literate students; students under the age of 7; students with specific educational needs that result in difficulty or hindrance to the development of interpersonal relationships and/or academic development (for example: autistic spectrum disorder); students whose guardians have not signed the Informed Consent Form; students who have not signed the Consent Form; students with specific physical needs that make anthropometric evaluation difficult or impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5g6jk5c	Effects of High Power Diode Laser Photobiomodulation on Bichat Ball Removal: a Split-Mouth Controlled Clinical Trial	Recruiting	Intervention	2023-11-02	<NULL>	<NULL>	6558	Effects of High Power Diode Laser Photobiomodulation on Removal of Buccal Fat Pads: a Split-Mouth Controlled Clinical Trial	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-14	Universidade Federal do Maranhão	Programa de Pós Graduação em Odontologia da Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-5g6jk5c	<NULL>	aesthetic-functional need for bilateral partial surgical removal of the buccal fat pads; complaint of unilateral or bilateral nibbling on the buccal mucosa; complaint of disproportionality of the lower third of the face; good systemic health condition, therefore no comorbidities	present systemic comorbidities; smokers; pregnant or breastfeeding women; signs of any pre-operative inflammatory or infectious condition; are using any medication that interferes with the pain mechanism; history of allergies or adverse effects that prevent the use of medications that will be used in the study; present any significant facial asymmetry; have progressive hemifacial atrophy; underwent facial liposuction, lipolysis injection or bichectomy procedure prior to the research; they wish to have the surgery just for aesthetic reasons.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-2c3t8gb	Local effect of Metformin gel 1% in Periodontal treatment of patients with Type II Diabetes Mellitus and Periodontitis	Recruitment completed	Intervention	2023-11-02	<NULL>	<NULL>	6559	Metformin gel in the Periodontal treatment of patients people with type II Diabetes Mellitus with Periodontitis	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-04-01	Centro de Ciências Biológicas e da Saúde CCBS - Universidade Estadual do Oeste do Paraná	Centro de Ciências Biológicas e da Saúde CCBS - Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2c3t8gb	<NULL>	Patients of both sexes with Periodontitis stages 1, 2, 3 or 4, grade B or C, presenting bleeding on probing and gingival inflammation. Patients must have the pathophysiological condition of Type II Diabetes Mellitus (diagnosed by endocrinologists) and use systemic Metformin. Patients who agree to participate in the study, signing the informed consent form. Patient aged between 18 and 70 years	Patients with a positive history in the last 6 months of broad-spectrum antibiotic therapy, steroidal anti-inflammatory drugs or immunosuppressive therapy in the 3 months prior to the study. Pregnant or lactating. History of periodontal treatment in the last 6 months. Smoking or quitting the habit for less than 5 months. Patients who have less than 4 teeth or have misaligned teeth in the dental arch. Patient under 18 years old or over 70 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-2g3hpyc	Analgesia after Infiltration at the removal site of the graft of the flexor tendons in Anterior Cruciate Ligament Reconstruction	Recruitment completed	Intervention	2023-11-01	<NULL>	<NULL>	6557	Analgesia in Multimodal Infiltration of the donor site of flexor tendons in Anterior Cruciate Ligament Reconstruction	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Clínica de Traumato-Ortopedia do Hospital Naval Marcílio Dias	Clínica de Traumato-Ortopedia do Hospital Naval Marcílio Dias	https://ensaiosclinicos.gov.br/rg/RBR-2g3hpyc	<NULL>	Participants who underwent Anterior Cruciate Reconstruction ACL reconstruction with grafts from the flexor tendons; of both sexes; aged between 18 and 50 years will be included	Patients submitted to revision of Anterior Cruciate Ligament ACL reconstruction, Anterior Cruciate Ligament ACL reconstruction using other grafts; submitted to multiligamentous reconstruction; valgus osteotomy of the tibia or concomitant cartilage repair procedure; allergy to any of the drugs; in chronic use of analgesics; with Body Mass Index BMI above 35 kg/m2 and patients with a history of previous knee surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-77qc49q	Assessment of  the female intimate area before and after the use of treated and untreated pantyliners	Recruitment completed	Intervention	2023-11-01	<NULL>	<NULL>	7569	Single-center, parallel, single blind clinical study to evaluate the urogenital microbiota and skin condition before and after wearing treated pantyliners with prebiotic and untreated control pantyliner (E003417A)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-07	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	Kimberly-Clark Brasil Industria e Comercio De Produtos De Higiene Ltda	https://ensaiosclinicos.gov.br/rg/RBR-77qc49q	<NULL>	Females; 18 to 45 years old; in good general health; with regular monthly menstrual cycles that are not expected to menstruate during the study; participants must have healthy and intact skin in the test areas, and be willing to comply with study requirements	Participants that are pregnant or intending to become pregnant during the study, or breast-feeding; participants that have a history of skin conditions or the presence of visible skin conditions on any skin testing sites; history of chronic or currently active gynecological pathologies or urogenital infections in the last 3 months; used systemic and/or topical antibiotics, antifungals, and/or corticosteroids within 4 weeks prior to visit 1 and throughout the study; any other medical condition or history that may compromise the study results or the subject’s safety	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:25
RBR-3xfbygd	Dental and skeletal comparison of rapid maxillary expansion supported by 2 versus 4 miniscrews during late adolescence	Recruiting	Intervention	2023-10-31	<NULL>	<NULL>	6551	Dentoskeletal comparison of rapid maxillary expansion anchored in 2 versus 4 miniscrews	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-12	Bauru Dental School - University of Sao Paulo	Bauru Dental School - University of Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3xfbygd	<NULL>	The inclusion criteria consist of: (1) patients of both sexes; (2) age between 14 and 18 years, in the final stage of mixed or young permanent dentition; (3) patients with unilateral or bilateral posterior crossbite; (4) patients with maxillary atresia.	The following will be excluded: (1) patients with a history of orthodontic treatment; (2) patients with systemic or neurological conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-42f35p9	What do Brazilian anesthesiologists know about value-based healthcare	Recruiting	Observational	2023-10-31	<NULL>	<NULL>	6553	Analysis of Brazilian anesthesiologists&apos; knowledge of value-based anesthesia: an observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-23	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-42f35p9	<NULL>	Trainee anesthesiologists as well as those already qualified, from both public and private hospitals in different Brazilian regions, who are older than 23 years, will be included	Anesthesiologists who refuse to sign the ICF (Informed Consent Form) or demonstrate prior knowledge of the study to be conducted will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-68w9xsy	Musas project: music for alleviating symptoms impact of Music in fatigue and emotion of women with breast Cancer: a three-arm randomized control trial	Recruitment completed	Intervention	2023-10-31	<NULL>	<NULL>	6554	Musas project: music for alleviating symptoms impact of Music Interventions in fatigue and emotional symptoms of women with breast Cancer: a three-arm randomized control trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-28	Liga Paranaense de Combate ao Câncer	Grupo Hadiak	https://ensaiosclinicos.gov.br/rg/RBR-68w9xsy	<NULL>	Women. Age 18 years or more. Auditory and cognitivelly able to understand the study and react to auditory stimuli. Diagnosed with initial or locally advanced breast cancer. Referred to adjuvant or neoadjuvant chemotherapy	Palliative care. Less than 6 total cycles of chemotherapy. Significant comorbidities. Psychotic episodes. Severe intellectual disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-2qz7vwt	Ammonia free cariostatic for dentine caries lesions treatment	Recruitment completed	Intervention	2023-10-31	<NULL>	<NULL>	6555	Silver Diamine Fluoride free of Ammonia (Riva Star Aqua) for dentine Caries lesions - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-08	Centro Universitário UNIESP	Centro Universitário UNIESP	https://ensaiosclinicos.gov.br/rg/RBR-2qz7vwt	<NULL>	Children from both genders whose parents accept and sign the informed consent form. Children from 3 to 10 years old that allows treatment will be included (good overall behaviour). Primary molars with cavitation into dentine	Children whose parents do not sign the consent form. Children who are absent on the day of treatment. Children who do not cooperate with the treatment. Teeth with dentine caries lesions with signs and symptoms of irreversible pulpitis and/or pulp necrosis (clinical pulp exposure, spontaneous pain, presence of fistula or abscess close to the tooth to be treated). Teeth with enamel defects (amelogenesis imperfecta, hypomineralization or hypoplasia)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-10w3x7r3	Bioimpedance, respiratory health and inflammation in adults with Cystic Fibrosis: a prospective observational study	Not yet recruiting	Observational	2023-10-31	<NULL>	<NULL>	6556	Phase angle of bioelectrical impedance, lung function, and systemic inflammation in adults with Cystic Fibrosis: a prospective observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-20	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP	https://ensaiosclinicos.gov.br/rg/RBR-10w3x7r3	<NULL>	Adults of both genders; aged 18 to 59; with Cystic Fibrosis; under the care of a specialized outpatient clinic at a tertiary hospital	Comorbidities characterized by systemic low-grade chronic inflammation or malabsorptive syndromes, except for those secondary to Cystic Fibrosis; malignant neoplasm; edema; chronic kidney disease with glomerular filtration rate less than 60 mg/dL; end-stage organ failure; amputated limbs; gastric or intestinal resections; implanted cardiac devices; chronic use of oral immunosuppressants or anti-inflammatory drugs; initiation of diuretic use or dose modification 3 months prior to recruitment; pulmonary exacerbations within 3 months of recruitment; ethical restrictions that prevent proper consent for study participation; women who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5y8ntfq	The effect of Strength Training (resistance) on inflammatory markers, physical performance and fatigue symptoms in women with fatigue resulting from Breast Cancer treatment	Not yet recruiting	Intervention	2023-10-30	<NULL>	<NULL>	6548	Understanding the role of Strength Training on fatigue (sensation and fatigability) in women with a history of Breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-07	Universidade Federal do Triângulo Mineiro	Grupo de pesquisa em exercício, nutrição e fisiologia aplicada	https://ensaiosclinicos.gov.br/rg/RBR-5y8ntfq	<NULL>	Women; over 25 years old; undergoing treatment for breast cancer or a breast cancer survivor; fatigue.	Practitioners of resistance exercises or similar exercises; vegetarian; smokers; alcoholics; with endocrine diseases; gynecological; joints; cardiac; myopathies; arthropathies; neuropathies; muscle disorders; thromboembolic; infectious diseases; metastases; concomitant tumors.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-3qmk24m	The effects of Whole Body Vibration on long term COVID patients	Recruiting	Intervention	2023-10-30	<NULL>	<NULL>	6549	Effectiveness of Whole Body Vibration exercise on the quality of life, functional capacity, strength and muscle thickness of patients with long COVID	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Programa de Pós-graduação em Fisioterapia - Universidade Federal de Pernambuco	Instituto de Medicina Integral Professor Fernando Figueira - IMIP/PE	https://ensaiosclinicos.gov.br/rg/RBR-3qmk24m	<NULL>	Individuals who have recovered from COVID-19 in moderate and/or severe forms will be recruited; who require hospitalization in a ward and/or intensive care unit; confirmed by RT-PCR test or serology of IgA, IgM and IgG antibodies; of both sexes; aged between 30 and 70 years	Patients who have uncontrolled hypertension; present impairment of the neuro-musculoskeletal system that impairs participation in the proposed assessment or training; have cognitive impairment that prevents them from answering the study questionnaires; prosthesis and/or pins and metal implants in lower limbs and pacemaker; pregnant women; recent unconsolidated fracture; risk of thromboembolism; vertigo and labyrinthitis; body weight over 120 kg (maximum load tolerated by the platform); who have participated in exercise programs after hospitalization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-4vhg5qd	Follow-up research on people affected by Monkeypox treated at the Evandro Chagas National Institute of Infectious Diseases (INI) of the Oswaldo Cruz Foundation (FIOCRUZ) and other collaborating centers	Recruiting	Observational	2023-10-30	<NULL>	<NULL>	6550	Surveillance study of Monkeypox cases among users of the Evandro Chagas National Institute of Infectious Diseases (INI) of the Oswaldo Cruz Foundation (FIOCRUZ) and collaborating sites	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-01	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-4vhg5qd	<NULL>	Male or female sex assigned at birth; Be greater than or equal to 18 years old; Have an unexplained acute skin rash; Having been identified as a suspected case of Monkeypox during any routine consultation in the INI/FIOCRUZ specialties or collaborating centers; Have been notified as a suspected case of Monkeypox by the INI/Fiocruz health surveillance service or collaborating centers	Do not sign the study&apos;s informed consent form; Any condition that, in the researcher&apos;s opinion, contraindicates the volunteer&apos;s participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-10yhrbnz	Osteopathic Manipulative Treatment (OMT) on patients with Cervicogenic Headache Pragmatic randomized controlled clinical trial	Recruiting	Intervention	2023-10-28	<NULL>	<NULL>	6546	Osteopathic Manipulative Treatment (OMT) in the management of patients with Cervicogenic Headache. Pragmatic randomized controlled clinical trial.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-22	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-10yhrbnz	<NULL>	Age between 18 years and 49 years; Both sexes; Unilateral headache, starting in the posterosuperior region of the neck or occipital region, eventually spreading to the oculofrontotemporal on the symptomatic side; Pain triggered by neck movement and/or positions sustained inadequate; Reduced range of motion in the cervical spine; Pain caused by external pressure at at least one cervical level superior (C0 to C3/C4); Present moderate to severe complaint and/or symptoms, not throbbing and not lacinating; Headache frequency of at least once a week for a minimum period of 3 months; Have a minimum disability score of 20% or more (or that is, 10 points or more on the 0-50 NDI scale; Be able to move independently with or without the use of assistance; Be able to understand enough Portuguese to be able to fill in the questionnaires;	Other primary headaches Migraine, Tension Headache; Bilateral headaches; Time less than 6 months after surgery on the cervical spine, head or neck; history of cervical injury; upper limbs or region facial; Performing an invasive procedure for pain relief in the last 3 months; Receiving physical therapy, osteopathic or chiropractic treatment in the last 3 months; If you have two or more positive neurological signs consistent with nerve root compression muscle weakness involving a large upper extremity muscle group, decreased upper extremity deep tendon reflex, or decreased or absent pinprick sensation in any upper extremity dermatome; Diagnosis of cervical spinal stenosis; Exhibit these bilateral upper extremity symptoms; Evidence of central nervous system involvement hyperreflexia, sensory disturbances in the hand, hand atrophy, unsteadiness during gait, nystagmus, loss of visual acuity, decreased face sensation, taste alteration, presence of pathological reflex signs; Inflammatory rheumatic diseases eg rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, systemic lupus erythematosus, etc.; Progressive neurological disease e.g. multiple sclerosis, Parkinson&apos;s disease, first neuron disease Unstable heart conditions;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-55p8vr4	The effect of Neuromodulation and Restriction Therapy on the upper limb of people after stroke	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6541	Effects of transcranial Direct Current Stimulation and modified Constraint Therapy on upper limb motor function in people after chronic Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-55p8vr4	<NULL>	Single episode of stroke, ischemic or hemorrhagic, with at least six months between the ictus and their inclusion in the study, proven by a medical report; aged between 40 and 70 years; classified with a degree of spasticity with a score less than or equal to 2, detected using the Modified Ashworth Scale for spasticity; active extension capacity of 10 degrees in the metacarpophalangeal and interphalangeal joints, and 10 degrees in the wrist joint; no cognitive deficit (score less than 24), verified using the Mini-Mental State Examination; pain threshold with a maximum score of 4 in the affected upper limb, verified using the Visual Analog Pain Scale	Those who had clinical evidence of multiple brain injuries and other comorbidities, inability to ambulate and instability to walk with the healthy upper limb (HUL) immobilized, failure to perform the training tasks with the paretic HUL, or symptoms of depression or severe anxiety, as verified by the Hospital Anxiety and Depression Scale, would be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-427g9ht	Comparison study of the different Surgical Techniques for the treatment of Benign prostatic growth with large volume: Endoscopic Laser Treatment x Minimally-invasive Abdominal Treatment x Endoscopic Treatment with Bipolar Energy	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6542	Randomized clinical trial evaluating the Surgical Treatment of large-volume Benign Prostatic Hyperplasia: Endoscopic Enucleation with Holmium Laser x Minimally-invasive Simple Prostatectomy x Bipolar Transurethral Resection of Prostate	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-30	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-427g9ht	<NULL>	Prostatic volume between 80 and 150mL measured by abdominal ultrasound of the prostate. Present at least one indication criteria for surgical treatment of Benign prostatic hyperplasia (BPH): renal failure with bilateral ureterohydronephrosis, recurrent macroscopic hematúria, acute urinary retention, recurrent urinary tract infection secondary to high post-void volume, moderate to severe voiding urinary symptoms even with clinical treatment interpreted by International Prostate Symptom Score (IPSS) &gt; 15 and/or maximum urinary flow (Qmax) &lt; 12mL/s,  moderate to severe voiding urinary symptoms interpreted by International Prostate Symptom Score (IPSS) &gt; 15 and/or maximum urinary flow (Qmax) &lt; 12mL/s in patients intolerant to pharmacological therapy	Prostate câncer. Neurogenic bladder. Previous prostatic surgeries. Bladder stones. Urethral pathologies. Impossibility of suspending anticoagulants or anti-platelet agentes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-2hs894w	Effects of Oxandrolone on clinical outcomes and muscle mass in patients with Septic shock	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6543	Effects of Oxandrolone on clinical outcomes and muscle mass in patients with Septic shock: a randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Estadual Paulista Júlio de Mesquita	Universidade Estadual Paulista Júlio de Mesquita	https://ensaiosclinicos.gov.br/rg/RBR-2hs894w	<NULL>	Individuals over 18 years of age; of both genders; hospitalized with a diagnosis of septic shock in the Intensive Care Service of the Hospital das Clínicas da Faculdade de Medicina de Botucatu from October 2023 to June 2025	Patients with the following characteristics will be excluded: pregnant women; noradrenaline dose &gt; 2.0µg/Kg/min; patients with non-functioning gastrointestinal tract; diagnosis of brain death; patients with a history of previous use of anabolic steroids; association with other types of shock (cardiogenic, hemorrhagic or hypovolemic); patients with breast or prostate cancer and those who spontaneously refuse to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-9kkjvnj	Pharmaceutical guidance for optimizing the use of asthma medications	Not yet recruiting	Intervention	2023-10-27	<NULL>	<NULL>	6544	Pharmaceutical intervention to optimize the use of inhalation devices in asthma patients: a randomized, open clinical tirial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-02	Universidade Federal do Rio Grande do Norte	Secretaria de Estado da Saúde Pública do Rio Grande do Norte - SESAP	https://ensaiosclinicos.gov.br/rg/RBR-9kkjvnj	<NULL>	Both sexes. Aged 18 years or older. Confirmed diagnosis of Asthma through spirometry. Patients currently using or starting the use of a dry powder inhaler (Aerolizer, Turbuhaler) and/or inhalation solution (Respimat system) on D0. Informed and voluntary consent to participate in the clinical trial	Conditions that may influence the learning of the inhalation technique (psychiatric, neurological, or rheumatological disorders). Presence of respiratory diseases other than asthma. Ongoing viral or bacterial respiratory infection. Dependency on third parties for DI handling. Hearing impairment. Severe visual impairment. Treatment with a different DI other than Aerolizer, Turbuhaler, and Respimat. Active smoking. Undergoing respiratory physiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-44vqd7r	Safety and efficacy evaluation of a health product using the product at home	Not yet recruiting	Intervention	2023-10-26	<NULL>	<NULL>	6538	Evaluation of gynecological and dermatological acceptability of a health product under normal conditions of use with cosmetic appreciation (volunteer opinion assessment)_	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-11	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Maredifiori Indústria e Comércio de Cosméticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-44vqd7r	<NULL>	Women; age between 18 to 59 years old;  phototype: I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; pregnant or lactating women; participants with a history of allergy to the material used in the study; atopy history; use of vaginal cream; participants with a history of allergy to products in the tested category; recent gynecological surgeries; discharges; immunodeficiency carriers; kidney, heart or liver transplants; active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); topical use with corticosteroids in the experimental area up to 8 days before the start of the study; any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5ghx4y6	Effects of acute administration of a single dose of Cannabis Extract on laboratory-induced pain: comparison with placebo	Not yet recruiting	Intervention	2023-10-26	<NULL>	<NULL>	6539	Investigation of the effects of acute administration of Full Spectrum Cannabis Extract on Experimentally Induced Pain: A randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2023-10-30	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo  FMRP - USP	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo  HCFMRP - USP	https://ensaiosclinicos.gov.br/rg/RBR-5ghx4y6	<NULL>	Participants aged at least 18 years; both genders; absence of current or previous history (self-reported) of substance abuse, psychiatric disorders and/or neurological disorders, cardiovascular diseases, pulmonary diseases, high blood pressure; absence of painful disorders and complaints of chronic or acute pain; score less than ten on the Patient Health Questionnaire (PHQ-9), on the Generalized Anxiety Instrument (GAD-7); absence of experience of pain of any kind in the seven days prior to the experimental session, assessed by means of a checklist questionnaire of pre-existing painful conditions and the perception of present pain (Visual Analog Pain Scale)	Adverse reactions of any nature after the use of cannabis extract; failure to complete the experimental tasks that make up the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-749zsx6	Effects of Non-Invasive Electrostimulation on students with Anxiety at an university in the Amazon: a randomized clinical trial	Not yet recruiting	Intervention	2023-10-26	<NULL>	<NULL>	6540	Effects of Non-Invasive Neuromodulation on academics with Anxiety Disorders at an university in the Amazon: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Instituto de Saúde e Biotecnologia	Instituto de Saúde e Biotecnologia	https://ensaiosclinicos.gov.br/rg/RBR-749zsx6	<NULL>	be aged between 18 and 40, of both sexes, be a university student at ISB/UFAM, have a clinical diagnosis, according to the criteria of the American Psychiatric Association 5th edition - DSM-V (2014), of anxiety disorders, and cognitive ability to understand the purpose of the research and to answer the scales and questionnaires	conditions such as uncontrolled epilepsy, individuals with metallic intracranial implants near the electrodes, pregnant women, history of brain surgery, tumor and undergoing psychotherapy at the time of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-2kk9vnh	The cognitive and motor effects of Immersive Virtual Reality in patients with Cognitive Impairment	Not yet recruiting	Intervention	2023-10-25	<NULL>	<NULL>	6536	Cognitive and motor effects of Immersive Virtual Reality in patients with Neurocognitive Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2kk9vnh	<NULL>	Will be included (1) elderly patients (&gt;60 years old); (2) of both genders; (3) with adequate command of the Portuguese language; that are classified into one of the following two categories: (3) Mild Neurocognitive Disorder – at least one domain with composite score less than or equal to – 1, but without criteria for dementia; (4) Mild Major Neurocognitive Disorder with CDR less than 2 and (5) accepting to participate in the study by signing the Informed Consent Form.	Individuals with (1) previous diagnosis of major neurocognitive disorder with CDR greater than or equal to 2 will be excluded; (2) presence of delirium, psychotic mental disorders, or substance-related mental disorders according to DSM-5 criteria; (3) severe retinal problems or severe visual impairment using corrective lenses; (4) severe uncorrected hearing deficit; (5) have decompensated cardiovascular diseases, such as angina, heart failure; (6) epilepsy; (7) motion sickness; (8) experiencing cybersickness during the familiarization game (9) health problem that makes it impossible to use immersive Virtual Reality; (10) serious clinical conditions with uncontrolled symptoms or instability and (11) missing the first 2 consecutive sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5xcszv2	The effect of a 3D Device compared to Elastic Bandages in controlling Swelling after Facial Surgery	Not yet recruiting	Intervention	2023-10-25	<NULL>	<NULL>	6537	Efficacy of a Personalized Rigid Device compared to Adhesive Tapes in controlling Edema in the postoperative period of Trauma Surgeries in Oral and Maxillofacial Surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade de Pernambuco - Departamento de Cirurgia e Traumatologia Buco-Maxilo-Facial	Núcleo de Tecnologias Estratégicas em Saúde (NUTES)	https://ensaiosclinicos.gov.br/rg/RBR-5xcszv2	<NULL>	Patients under the care of the Oral and Maxillofacial Surgery and Traumatology specialty at the Campina Grande Trauma Hospital, aged 18 years or older, regardless of gender, with unilateral and isolated zygomatic fractures classified as type III, IV, and V according to Knight and North&apos;s classification (1961), and treated by the same operator (surgeon) during the same surgical procedure	Presence of neurological deficit after the trauma episode; history of surgery in the facial region prior to the current trauma; systemic disease without clinical control; continuous drug therapy for special patients, with coagulopathies, rheumatic and autoimmune diseases; chronic use of nicotine, alcohol or drugs; trans or postoperative complications; sensitivity/allergy to elastic tape or any component that makes up the personalized rigid device; deny participation in the study and do not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-5hs9prz	Clinical evaluation of a Monochromatic Flow Composite Resin of dental restoration	Recruiting	Intervention	2023-10-24	<NULL>	<NULL>	6532	Clinical performance of a Flow Composite Resin with intelligent chromatic technology for restoration of Non-Carious Cervical Lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5hs9prz	<NULL>	Good general health;good oral hygiene;present at least 20 teeth under occlusion;at least two non-carious cervical lesions comparable in size;format and dimensions;non-retentive;deeper than half a mm;and involve both the enamel and dentin of vital teeth;The cavo-superficial margin cannot involve more than 50% of the enamel	Extremely poor oral hygiene;using orthodontic devices;severe or chronic periodontitis;heavy bruxism habits;known allergy to resin-based materials or any other material used in this study;pregnant or lactating women;chronic use of anti-inflammatory;analgesic and psychotropic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-2typh66	Effects of two types of associated brain stimulation to improve unilateral spatial neglect after stroke	Not yet recruiting	Intervention	2023-10-24	<NULL>	<NULL>	6533	Effect of Transcranial Magnetic Stimulation by Theta Burst Modality as a Priming Effect to Transcranial Direct Current Stimulation in Unilateral Spatial Neglect after Stroke: TITAN TRIAL	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Departamento de Clinica Médica	Departamento de Clinica Médica	https://ensaiosclinicos.gov.br/rg/RBR-2typh66	<NULL>	Individuals of both sexes, aged 18 to 85 years, with a diagnosis of ischemic stroke in the subacute phase (7 days to 3 months from the onset of symptoms, due to lesions of the right virus, confirmed by tomography CT and or magnetic resonance imaging (MRI) and unilateral spatial neglect diagnosed by checking less than 129 on the Behavior Intention Test - BIT	Individuals with any metal in the head segment, skin lesions in the electrode placement area, clinical instability, severe cognitive impairment, global aphasia, visual disturbances prior to stroke, hemorrhagic stroke, previous Rankin bigger then 1, bilateral lesions, pacemaker, epilepsy, severe CHF or unstable conditions that may pose a risk to the participant, concurrent diagnosis of rapidly deteriorating illness (eg, terminal cancer), participating in studies involving medications or other interventions, pregnancy, or other associated neurological conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-5t2y624	Nursing teaching in cardiovascular assessment: undergraduate students learning	Recruitment completed	Intervention	2023-10-24	<NULL>	<NULL>	6535	Clinical Simulation in teaching cardiovascular nursing: external validation and testing of undergraduate students learning	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Universidade de Fortaleza	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-5t2y624	<NULL>	Students enrolled in the fourth semester (semiology and semiotics module in nursing); Students in first contact semiology and semiotics in nursing	Transfer students from other colleges or universities; Students who have already attended the semiology and semiotics module in nursing, as well as for all modules in which this is a prerequisite; Academics with previous training in the nursing technician course or who have experience or prior knowledge about the subject studied for this public; Students transferred from other universities/colleges	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-8djnqpf	Balance exercise program with unstable base, aerobic demand and cognitive task: effects in the elderly	Recruitment completed	Intervention	2023-10-23	<NULL>	<NULL>	6529	Dynamic body balance training in association with support base malleability, aerobic demand and cognitive task: effects in healthy elderly subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-12	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8djnqpf	<NULL>	not having musculoskeletal; sensory or neurological diseases that could affect body balance; not using medications that affect balance	Participants will be excluded if they do not present the minimum attendance stipulated; injuries that disable the participation of volunteers, failure to perform the tasks proposed in class.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-6hn5nnr	Effect of sexual counseling on sexual function and quality of life of pregnant women	Recruiting	Intervention	2023-10-23	<NULL>	<NULL>	6530	Effect of the Pilset model on the sexual function and sexual quality of life of pregnant women: a quasi-experimental study	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-03	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6hn5nnr	<NULL>	Pregnant women monitored by Family Health teams (eSF) during the data collection period; with a sexual partner; age between 20 and 35 years; who are at most 18 weeks gestational on the day of the first intervention	Women accompanied by high-risk prenatal care, whose pregnancy resulted from sexual violence or who experience violence by an intimate partner; who present psychic alteration in the use of medications (selective serotonin reuptake inhibitors, antipsychotics, antiepileptics, anxiolytics, antidepressants and hypotensives) because they affect the female sexual response (FEBRASGO, 2017); dropouts after starting data collection; reclassification as a high-risk pregnant woman (BRASIL, 2012); missing two or more sessions of the educational intervention; if during the intervention or data collection period the woman gives birth; come to death or miscarriage; or the pregnant woman changes her address in a way that changes the link to the Basic Health Unit (UBS)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-2h3tz6f	Exercise protocols to prevent Muscle Loss after Bariatric Surgery and improve Sleep-Disordered Breathing	Not yet recruiting	Intervention	2023-10-20	<NULL>	<NULL>	6525	Analysis and control of muscle Mass Loss After Bariatric Surgery and possible implications for Sleep-Disordered Breathing: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Faculdade de Ciencias Medicas de Minas Gerais	Instituto Bariátrico	https://ensaiosclinicos.gov.br/rg/RBR-2h3tz6f	<NULL>	Participants aged between 18 and 65 years; of both genders; who seek the Bariatric Institute to undergo bariatric surgery;  will be operated on by disabsorptive, restrictive techniques or a combination of both	Participants who have surgical complications after hospital discharge; participants who do not show satisfactory adherence to the proposed exercise programs; participants who have a clinical condition that precludes the prescription of physical activity in the postoperative period of bariatric surgery;  participants who need a new intervention surgery during the study period; participants who declare themselves pregnant during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-848ygb3	Evaluating custom-made dental implants placed immediately after tooth extraction with delayed prosthetic restoration: a pilot study	Recruitment completed	Intervention	2023-10-20	<NULL>	<NULL>	6526	Immediate placement delayed loading of a patient-specific one-piece CAD/CAM designed dental implant: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-03	Faculdade de Odontologia da Universidade de São Paulo	iDentical Inc	https://ensaiosclinicos.gov.br/rg/RBR-848ygb3	<NULL>	Age between 22 to 75 years; Indication for the extraction of a single-rooted tooth with immediate implant placement for a single-unit prosthetic restoration; Adequate bone height and width with intact cortical plates (&gt; 1 mm in thickness) at the surgical site for implant placement; Satisfactory soft tissue quality, quantity, and morphology; Ability to fully comprehend and provide informed consent; willingness and ability to adhere to study procedures and instruction	"General contraindications for dental and/or surgical treatments; Presence of apical lesions or peri-radicular bone loss; Untreated periodontitis, peri-implantitis, or other uncontrolled oral infections; Inadequate oral hygiene (plaque score &gt; 25% or bleeding on probing &gt; 50% of sites); Bruxing or clenching habits; Cuspid protected occlusion; Presence of diabetes, cancer, HIV infection, or bone metabolic diseases; Concurrent or recent use of immunosuppressants, systemic corticosteroids, intramuscular or intravenous bisphosphonates within two months prior to the study; Undergoing or having undergone radiation therapy and/or chemotherapy; Current smokers or individuals who had not quit smoking for at least two years; Pregnant or lactating women, and women of childbearing age intending to become pregnant during the study; Individuals  requiring replacement of additional teeth during the study period or with ongoing implant treatments; or participants in other studies clinical studies involving therapeutic intervention (medical or dental);
Additional exclusion criteria specific to the time of tooth extraction and implant insertion:
Exclusion criteria at time of extraction:
Insufficient or fractured bone at the extraction site (buccal plate &lt; 1 mm thick or fenestrations); Fractured, chipped, or distorted tooth root pos-extraction; Significant defect in the extraction socket with one or more missing bone walls; Active infection present in the extraction socket; Communication between the extraction socket and sinus, inferior alveolar nerve canal or mental foramina; Tooth root not compatible with the dimensions of the intended implant device;
Exclusion criteria at time of implant insertion:
Presence of infection, pain, bleeding, or significant tissue swelling or trauma before implant placement; Change in medical or dental history that related to the exclusion criteria before tooth extraction; Failure to place the implant within 14 days of the extraction"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-7d492mg	Treatment of Patellar Chondromalacia through Physical Exercises	Recruiting	Intervention	2023-10-20	<NULL>	<NULL>	6527	Exercises Therapy in Patellar Chondromalacia: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Comunitária de Região de Chapecó	Universidade Comunitária de Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-7d492mg	<NULL>	Participants of both genders. Aged between 18 and 45 years. With a clinical diagnosis of patellar chondromalacia (grades I, II, III, and IV according to the classification of the International Cartilage Repair Society - ICRS)	Participants who have undergone recent surgical procedures (in the last three months). Peripheral vascular disease diagnosis. Diagnosis of hypertension. History of deep vein thrombosis or pulmonary embolism. Currently on anticoagulants. Previous history of myocardial infarction or prior stroke. Currently using type II collagen or chondroprotective agents. Patients who report knee joint injections in the last six months. Those with any type of gait alteration or difficulty. Lower limb deformity or axis deviation. Ligamentous or meniscal injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-86wzhcr	Effect of guidelines on Eating Behavior and Sleeping Patterns of shift workers: a study with Military Police officers from the 18th BPM – Catalão/GO	Recruitment completed	Intervention	2023-10-19	<NULL>	<NULL>	6522	Effect of Nutritional Counseling and Sleep Hygiene on the Eating Behavior and Sleeping Pattern of shift workers: a clinical case study of Military Police officers assigned to the 18th BPM – Catalão/GO	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-08	Universidade Federal de Catalão	18º Batalhão de Polícia Militar do Estado de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-86wzhcr	<NULL>	Belonging to the 18th Battalion of the Military Police of the State of Goiás (18th BPM), carrying out its activities on a 24/72 hour duty schedule; Be a member of active military police; Age over 18 and under 60 years old; You have an active WhatsApp® application on your cell phone	During the research, you are removed from your duties for reasons not controlled by the research; Have a diagnosis of chronic complications such as kidney failure, blindness, limb amputation, among others	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-4pgd3ct	Complementary therapies for Depression	Recruiting	Intervention	2023-10-19	<NULL>	<NULL>	6523	Complementary therapies in the treatment of Major Depressive Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4pgd3ct	<NULL>	Current depressive episode; Age between 18 and 40 years old; Study/ work in UFRN; Have internet connection to allow the usage of the app on the smartphone or computer website.	Diagnosis for mental illnesses other than major depressive disorder; Prescription of any medicine with psychiatric, neurological, neurovegetative, cognitive or mood effect other than antidepressants; Have any phobic symptom against injection, blood or wound; Pregnancy and lactation; Any physical or mental disability that make impossible the execution of the complementary therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-10nyxwkr	Effect of Photobiomodulation and Enamel-Derived Matrix Proteins on Bone Repair in Maxillary Sinuses grafted with Deproteinized Bovine Bone	Recruiting	Intervention	2023-10-19	<NULL>	<NULL>	6685	Effect of Photobiomodulation and Enamel-Derived Matrix Proteins on Bone Repair in Maxillary Sinuses grafted with Deproteinized Bovine Bone - A Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10nyxwkr	<NULL>	The patient required to present between 18 and 60 years old. need unilateral or bilateral elevation of the floor of the maxillary sinus for subsequent installation of osseointegrated implants. present bone availability associated with the alveolar ridge adjacent to the maxillary sinus less than or equal to 3mm. present good systemic health. present at least less than 4 months of healing of the socket after tooth extraction	Smokers. decompensated diabetics. patients with chronic or aggressive periodontitis. patients who use drugs that alter bone metabolism. patients who have chronic infections of the upper airways. patients who chronically use anti-inflammatory drugs and antibiotics. people with bruxism. alcoholics. drug addicts. pregnant women or who wish to become pregnant in the next year. history of radiotherapy treatment in the head and neck region. patients with pathologies that affect bone metabolism. patients who have had a major disruption of the sinus membrane during surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-5h3sttg	Does daily consumption of two propolis capsules for three months improve the health conditions of obese women?	Recruiting	Intervention	2023-10-18	<NULL>	<NULL>	6515	Effects of supplementation with red propolis on the metabolic profile and body composition of obese women: a double blind randomized clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal de Alagoas	Hospital Universiário Professor Alberto Antunes	https://ensaiosclinicos.gov.br/rg/RBR-5h3sttg	<NULL>	Women; between 19 and 40 years of age; obese (Body Mass Index greater than 35 kg/m^2); enrolled in the Bariatric Surgery Program at the Prof. Alberto Antunes University Hospital, Maceió, Alagoas	Being pregnant or lactating; making use of psychotropic drugs; having undergone recent surgery (last 6 months); being allergic to bee products and; living in a municipality outside the metropolitan region of Maceió (due to the difficulty of moving to the research location)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-8vfz74n	Online and/or face-to-face Pilates in the floor training as a treatment strategy for patients with symptoms after infection by COVID-19	Recruiting	Intervention	2023-10-18	<NULL>	<NULL>	6516	Remote and/or face-to-face Mat Pilates training as a rehabilitation strategy for patients with post-COVID-19 syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Faculdade de Medicina da Universidade Federal de Uberlândia	Programa de Pós-Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8vfz74n	<NULL>	Patients referred by Hospital de Clínicas; after hospital discharge; with symptoms of post-COVID-19 syndrome; Patients aged between 18 and 60 years; Patients without functional limitations that prevent them from performing physical rehabilitation exercises; Patients without serious comorbidities	Inability to perform rehabilitation exercises and activities; Discontinuation of the rehabilitation protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-10mxzptc	Effects of knee clicking on thigh muscles and walking in people with and without knee pain	Not yet recruiting	Observational	2023-10-18	<NULL>	<NULL>	6517	Repercussions of knee crepitus on objective aspects of the muscle and locomotor functions of people with and without Patellofemoral Pain: main project	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10mxzptc	<NULL>	Both genders; aged between 18 and 35 years; unilateral pain in the anterior, retro, or peripatellar region; insidious pain present for at least 3 months; self-reported pain intensity greater than 3 when quantifying the worst pain experienced in the knee in the week prior to screening, using a numerical scale ranging from 0 to 10; a score lower than 83 on the Anterior Knee Pain Score (AKPS) questionnaire	Bilateral knee pain complaints; history of surgery in any lower limb joint; history of patellar subluxation or dislocation; clinical evidence of meniscal injury; ligamentous instability; patellar tendinopathy; osteoarthritis in any lower limb joint; the presence of referred pain originating from the spine or any musculoskeletal condition more severe than patellofemoral pain; neurological disease; previous treatment for patellofemoral pain in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-3vskx79	Evaluation of the use of Analgesic Medication before Surgery to reduce Anxiety in patients who will undergo Wisdom Teeth Extraction: clinical, double-blind, randomized trial	Recruiting	Intervention	2023-10-18	<NULL>	<NULL>	6518	Evaluation of the use of Preemptive Analgesic Medication in reducing Anxiety in patients undergoing Third Molar Extractions: clinical, double-blind, randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-04	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-3vskx79	<NULL>	Young patients, between 20 and 40 years old; Both genders; ASA I and II (specific anamnesis questionnaire); Patients who need the removal of a lower third molar that requires making a surgical flap and osteotomy; Absence of signs and symptoms of infection at the site to be operated on; Accept to participate and sign the Informed Consent Form (TCLE).	Allergy or history of allergy to any medication; Patients who are pregnant or breastfeeding; Patients using antidepressant medication or other central nervous system depressants; Any contraindication for the use of opioids associated with paracetamol; Patients with active infection at the surgical site.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-4292nhn	Telerehabilitation in the postoperative period of Breast Cancer	Data analysis completed	Intervention	2023-10-18	<NULL>	<NULL>	6519	Effects of Telerehabilitation in patients submitted to surgical treatment of Breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Hospital Universitário João de Barros Barreto	Hospital Universitário João de Barros Barreto	https://ensaiosclinicos.gov.br/rg/RBR-4292nhn	<NULL>	"Patients with age above 18 years. be male and female. having a diagnosis of breast cancer in
all of its clinical stages. having undergone surgery for the treatment of breast cancer
mom. be in a period of 15 days after surgery. show ability to preserved verbal communication. being accompanied at the João de Barros Barretos University Hospital"	Having an associated disease that may generate some other type of functional impairment. have high-intensity pain. not have access to a cell phone. do not accept to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-5qq77rs	The result of the PaliEnf application in relation to improving the records of nurses working in a pediatric oncology intensive care unit	Recruiting	Intervention	2023-10-17	<NULL>	<NULL>	6511	The effect of PaliEnf on the quality of nurses&apos; registration in a pediatric oncology intensive care unit	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-09-25	Programa Acadêmico em Ciências do Cuidado em Saúde - Faculdade de Medicina da Universidade Federal Fluminense	Instituto Nacional de Câncer	https://ensaiosclinicos.gov.br/rg/RBR-5qq77rs	<NULL>	Phase 1 predictive usability assessment – researchers; professionals; professors with expertise in the development of health information technologies belonging to the GESAEUFF and NUPESICA research groups registered in the Directory of Research Groups in Brazil of the National Council for Scientific and Technological Development (CNPq); both genders. Prospective usability assessment - professional nurses with experience in pediatric oncology or pediatric palliative care; both genders. Training nurses&apos; clinical reasoning through fictitious case studies and training with the PaliEnf application: clinical nurses who are actively working in the Pediatric Oncology Intensive Care Unit (PICU) during the research period; both genders. Phase 2: Quasi-experiment - nurses&apos; records in the medical records of children and adolescents who were admitted to the Pediatric Oncology Intensive Care Unit (PICU) during the research period	Phase 1 (stage 1) predictive assessment: participants with experience period less than five years. Phase 1 (stage 1) prospective assessment: none, all nurses considered specialists in pediatric oncology according to the criteria proposed by Jasper who participate will have their analyzes considered. Phase 1 (stage 3): none, everyone who enters and remains in the research will be trained and their progress will be evaluated. Phase 2: records of children and adolescents who remained hospitalized for less than four days and records selected post-intervention whose nurse&apos;s progress was not generated by the PaliEnf application report	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-2zkkxr3	Development and evaluation of the effectiveness of cosmetics in conjunction with aesthetic procedures	Recruitment completed	Intervention	2023-10-17	<NULL>	<NULL>	6512	Assessment of the effectiveness of cosmetic formulations, whether or not combined with non-invasive aesthetic procedures, through Image Analysis or Cutaneous Bioengineering	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Faculdade de Ciências Farmacêuticas da Unicamp	Faculdade de Ciências Farmacêuticas da Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-2zkkxr3	<NULL>	Women; aged 30 to 65 years; agree with the study conditions; ability to understand and follow the instructions; agree to avoid sun exposure during the study; do not use other cosmetics in the test region throughout the study; be available to attend laboratory sessions on scheduled days; do not wash the test skin region for at least 2 hours before analysis; not having performed aesthetic procedures for at least 3 months	Lack of cognitive capacity; not understanding the method to be used; be pregnant or breastfeeding; present lesions compatible with active infectious diseases; history of aesthetic plastic surgery in the facial region; history of use of botulinum toxin, fillers or threads; history of recent facial aesthetic treatment, in less than 3 months; have generalized dermatological diseases, such as psoriasis or vitiligo; allergy to any cosmetic product; present systemic diseases with proven effects on the skin; be on continuous treatment with corticosteroids, antihistamines, diuretics, antibiotics, analgesics, anticoagulants, which directly or indirectly affect the skin; carry out immunosuppressive therapy; being treated for endocrine disorders; oophorectomy or hysterectomy; present allergic reactions in the test region during the study; have lesions, wounds, scars, tattoos or piercings in the test region of the skin; presence of metal pins or plates in the craniofacial region; neoplasms, cancer, growing epiphyseal plate and venous thrombosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-8cfptjf	Effects of perioperative fasting abbreviation in dentofacial corrective surgery	Recruitment completed	Intervention	2023-10-17	<NULL>	<NULL>	6513	Effects of perioperative fasting abbreviation in orthognathic surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-10	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8cfptjf	<NULL>	Volunteers with dentofacial deformity, with indication for correction by orthognathic surgery of the jaws; age between 18-60 years; physical status (ASA) I or II; body mass index less than 30 kg/m2; who can decide about their participation in the study.	Volunteers with allergies to the drugs used in the research; milk protein allergy; with diseases that may affect gastric emptying, such as hiatal hernia and gastroesophageal reflux; diabetes; use of hypoglycemic agents; gestation; rheumatic diseases;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-44q9k6q	Effect of 17% Glycolic Acid in Primary Endodontic Treatment: Randomized Clinical Trial	Recruiting	Intervention	2023-10-17	<NULL>	<NULL>	6514	Effect of 17% Glycolic Acid on Periapical Healing in Primary Endodontic Treatment: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-31	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-44q9k6q	<NULL>	Healthy volunteers; both genders; non smokers; previously initiated endodontic therapy	Smoking volunteers; history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies, endodontic retreatment, root resorption, immature/open apex, root canal where patency of the apical foramen cannot be established	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-73j768n	Effect of Laser and Blood Concentrates on Bone Repair in Maxillary Sinuses Grafted with Deproteinized Bovine Bone	Recruiting	Intervention	2023-10-17	<NULL>	<NULL>	6683	Effect of Photobiomodulation and Platelet-Rich Fibrin on bone repair in maxillary sinuses grafted with Deproteinized Bovine Bone	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-73j768n	<NULL>	The patient required to present between 18 and 60 years old, need unilateral or bilateral elevation of the floor of the maxillary sinus for subsequent installation of osseointegrated implants. present bone availability associated with the alveolar ridge adjacent to the maxillary sinus less than or equal to 3mm. present good systemic health. present at least less than 4 months of healing of the socket after tooth extraction	Smokers. decompensated diabetics. patients with chronic or aggressive periodontitis. patients who use drugs that alter bone metabolism. patients who have chronic infections of the upper airways. patients who chronically use anti-inflammatory drugs and antibiotics, people with bruxism, alcoholics, drug addicts. pregnant women or those who wish to become pregnant in the next year. history of radiotherapy treatment in the head and neck region, patients with pathologies that affect bone metabolism. patients who have had a large rupture of the membrane during surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-8rv93wn	Evaluation of the use of Cannabidiol in Third Molar Extraction	Not yet recruiting	Intervention	2023-10-17	<NULL>	<NULL>	6684	Evaluation of the use of Cannabidiol in Third Molar Extraction Surgeries	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2024-01-15	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8rv93wn	<NULL>	Patients of both genders. aged between 18 and 60 years. who are systemically healthy and who require surgery to remove the four third molars	Patients using drugs acting on the central nervous system. decompensated diabetics (glycated hemoglobin above 8%). consumption of any medication 15 days prior to inclusion in this study, patients with hypersensitivity to the drugs to be used in postoperative care, pregnant women or during lactation. chronic smokers and alcoholics. presence of periapical lesions. presence of pericoronitis lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:52
RBR-244m9ng	Effects of Breathing and Leg Muscle Training in Patients with Heart Failure	Recruitment completed	Intervention	2023-10-16	<NULL>	<NULL>	6509	Effects of Inspiratory and Peripheral Muscle Training in Patients with Heart Failure	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-01	Instituto Nobre de Cardiologia	Centro Universitário Nobre	https://ensaiosclinicos.gov.br/rg/RBR-244m9ng	<NULL>	Individuals of both sexes with heart failure (CHF); Functional class III and IV according to the New York Heart Association classification; aged over 18 years.	Patients with unstable ventricular arrhythmia; Peripheral vascular disease; Acute respiratory disease; Unstable angina; Aortic stenosis; Current smoking; Chronic kidney disease or undergoing hemodialysis; Fever and/or infectious disease; Malignant neoplasms; Cognitive impairment; Failure to perform the proposed techniques; Failure to sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-7p43fkc	Drug delivery systems through eye drops for the treatment of Dry Eye symptoms	Recruiting	Intervention	2023-10-16	<NULL>	<NULL>	6510	Drug delivery systems for treating Diseases of the Anterior Segment of the Eye	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2023-03-31	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7p43fkc	<NULL>	The authors intend to include 60 participants, divided into three groups of 20 (Experimental Group I: insulin eye drops; Experimental Group II: cannabidiol eye drops; Placebo Group: eye drops without active ingredient). Subjects must meet all inclusion criteria to be eligible to participate in the study: subjects of any color and gender, over 18 years of age at the time of enrollment; read, understand, and sign the informed consent form; understand the study procedures and adhere to them throughout the study; have a history of dry eye, and have used tear-lubricating agents within the last 4 months; basal tear &lt;5 mm; Corneal coloration 2 (NEI grading system, Lemp 1995) in at least one eye	Subjects who meet any of the exclusion criteria at visit 1 will be excluded from participation in the study: subjects who have any active infectious ocular conditions; individuals with inflammatory eye diseases (eg, conjunctivitis, keratitis, uveitis, or others) unrelated to dry eye; continued use of topical eye medications (including ocular cyclosporine and glaucoma medications) with the exception of artificial tears or lubricating ointments; taking medications that can cause dry eyes immediately prior to this study (Wong, Lan et al. 2011); any physical or mental disability that impedes participation and the ability to give informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-2vxzvkz	Effectiveness in the reduction of Dentin Hypersensitivity and assessment of quality of life in patients using 8% Arginine-based toothpaste and low-intensity laser: interventional study	Recruiting	Intervention	2023-10-13	<NULL>	<NULL>	6505	Efficacy in reducing dentin hypersensitivity and assessing quality of life in patients using 8% arginine-based dentifrices and laser photobiomodulation of low intensity. Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-04	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-2vxzvkz	<NULL>	Individuals must be at least 18 years old; clear clinical presence of alterations such as abrasion, attrition and erosion in anterior and/or posterior teeth; present hypersensitivity in two non-adjacent teeth; response to air jet stimulus for one second in the cervical region, as defined by score 2 or 3 on the Schiff scale, for sensitivity to air stimulus; visible plaque index and gingival bleeding index less than 20%.	Individuals with allergies to any product to be tested; individuals with clinical presence of serious pathologies in the soft tissues; individuals undergoing chemotherapy and radiotherapy; individuals with gingivitis and/or periodontitis; subjects who started taking anticonvulsants, antihistamines, sedatives, tranquilizers, anti-depressive, anti-inflammatory or analgesic drugs within one month before the start of the study or who would start taking them during the study; subjects who took antibiotics up to three months before the study; individuals who are participating in another study; pregnant or breastfeeding women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-8fqyxjc	Immediate effects of the Hook on Pain and Mouth Opening after Fitting Dental Appliances	Not yet recruiting	Intervention	2023-10-13	<NULL>	<NULL>	6506	Immediate effects of Diacutaneous Fibrolysis on Pain assessment and Mouth Opening after Orthodontic Appliance Placement	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-16	Instituto de Saúde e Biotecnologia	Instituto de Saúde e Biotecnologia	https://ensaiosclinicos.gov.br/rg/RBR-8fqyxjc	<NULL>	Volunteers starting orthodontic treatment aged between 12 and 45 years; accepting and signing the conditions of the study in accordance with the Informed Consent Form and Assent Form; good general health; absence of caries lesions or periodontal diseases	Use of analgesic or anti-inflammatory medication; fibromyalgia sufferers; volunteers with Temporomandibular Disorder and pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-4ht99zx	Evaluation of the use before surgery of the combination of two drugs Ibuprofen l-arginine and Dexamethasone on postoperative inflammatory markers, quality of life, sleep quality and pain catastrophizing in lower third molar surgeries	Recruitment completed	Intervention	2023-10-13	<NULL>	<NULL>	6507	Evaluation of the preemptive and preventive use of coadministration of Ibuprofen l-arginine and Dexamethasone on postoperative inflammatory markers, quality of life, sleep quality and pain catastrophizing in lower third molar surgeries: a randomized, split-mouth, factorial, controlled clinical trial	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-4ht99zx	<NULL>	Healthy individuals of both sexes; aged between 18-35 years; in need of removal of the two lower third molars; will be invited to participate in this study. In addition to these, the following inclusion criteria will also be adopted: semi-erupted or non-erupted mandibular third molars; third molars that present, on panoramic radiography, similar patterns of root formation, position and degree of impaction when comparing the right and left sides of each volunteer	Volunteers who meet at least one of the following criteria will be excluded: smokers; pregnant or lactating women; users of medications that interact with the drugs used in this study; carriers of orthodontic bands in mandibular second molars; confirmed history of allergy to NSAIDs or corticoids; signs of any preoperative inflammatory or infectious condition; systemic diseases; neurological disorders. In addition, the volunteer who has used any NSAID or corticoid within a period of up to 21 days before the surgical procedure will also be excluded from the research due to the possibility of a residual effect of the drug eventually used, which may influence the outcomes of the present study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-10vpc86k	Immediate effect of an electrostimulation session for Menstrual Cramp pain	Recruiting	Intervention	2023-10-13	<NULL>	<NULL>	6508	Immediate effect of an electrostimulation session on pain related to Primary Dysmenorrhea	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-10vpc86k	<NULL>	Women without children; aged between 18 and 45 years; with regular menstrual cycle; with primary dysmenorrhea assessed with 3 points or more for dysmenorrhea pain intensity by Numerical Pain Scale (END); and who had never had previous contact with Transcutaneous Electrical Nerve Stimulation (TENS).	Pregnant women; postpartum women up to 6 months after delivery; women using an intrauterine device; presence of skin lesions at the electrode application site; with self-reported neurological and/or heart diseases; diagnosis of gynecological disorders (such as endometriosis, uterine fibroids, etc.) that may be related to secondary dysmenorrhea.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-103yr8h9	Acute effect of Electrical Stimulation applied to the scalp on pelvic floor muscle contraction function in healthy women	Data analysis completed	Intervention	2023-10-12	<NULL>	<NULL>	6502	Acute effect of Transcranial Direct Current Stimulation (electrical stimulation applied to the scalp) on the function of contraction (as if holding urine and then relaxing) of pelvic floor muscles (muscles that control urine and stool) in healthy women	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-09-05	Angela Cristina Ledur	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-103yr8h9	<NULL>	Healthy women; Nulliparous;18 and 45 years; sexually active in the last four weeks.	Participants who present any type of symptom or conditions that are linked to any change in the bladder, bowel and vagina/pelvis evaluated by the sample characterization form and applied questionnaire; chronic degenerative diseases; neurological disease; psychiatric disease; women who have undergone previous pelvic floor reeducation programs and/or pelvic floor surgeries for treatment of urinary infection or other conditions in the pelvic region; pregnant women; women with pacemaker or present any contraindications to the use of transcranial direct current stimulation; or present anesthesia or hyperesthesia at the transcranial direct current stimulation application site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-9pr8j3x	The use of Botox in the masticatory and throat musculature as a treatment of sleep apnea: a pilot study	Recruiting	Intervention	2023-10-12	<NULL>	<NULL>	6503	The use of botulinum toxin in the masticatory and constrictor musculature of the pharynx as an option in the treatment of obstructive sleep apnea: a pilot study	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-05-22	Hospital Universitário Gaffrée e Guinle	Hospital Universitário Gaffrée e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-9pr8j3x	<NULL>	Age equal to or greater than 18 years old up to 60 years old; both genders; with a diagnosis of mild or moderate or severe obstructive sleep apnea gravity; body mass index&lt;32; tonsils with grade I or II; the presence of Modified Mallampati I or II	Facial deformities; grade III or IV tonsils or adenoid hypertrophy greater than 50% or tumors; modified Mallampati III or IV; nasal obstruction that requires surgical treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-655vxdd	Effect of Strength, Aerobic and Concurrent Training on memory, musculature and intestinal health in the elderly	Not yet recruiting	Intervention	2023-10-11	<NULL>	<NULL>	6498	Effect of Strength, Aerobic and Concurrent Training on cognitive, neuromuscular parameters and the microbiota-intestine-brain axis in elderly people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-655vxdd	<NULL>	Age over 60 years. Elderly men and women. Body mass index below 30. Present physical conditions to carry out the exercise protocol. Have not been performing any regular physical activity for at least three months. Without a history of practice competitive sports throughout life. Achieve a score equal to or greater than 24 on the Mini-Mental State Examination. Achieve a score of up to 9.11 on the Baecke Physical Activity Questionnaire, the cut-off point adopted for low intensity of daily physical activity	"Use of antidepressants, antiepileptics, anticonvulsants, psychoactive drugs or other medications that act on the Nervous System. In use of antimicrobials for 30 days. In use of chemotherapy/immunotherapeutics
In use of probiotics. In use of metformin and or proton pump inhibitor. On enteral diet. Recently hospitalized for 30 days. Acute or chronic bowel conditions (diarrhea, inflammatory bowel disease, Irritable Bowel Syndrome). Bariatric disease. Chronic diseases (diabetes). Cancer. Rheumatological diseases. Neurodegenerative diseases. Autoimmune diseases"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-4msk3yg	Effect of Fludroxycortide and Imiquimod creams in the treatment of lip lesions resulting from chronic sun exposure	Not yet recruiting	Intervention	2023-10-11	<NULL>	<NULL>	6499	Effect of Fludroxicortide and Imiquimod creams on the treatment of Actinic Cheilitis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-05	Fernanda Gonçalves Salum	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4msk3yg	<NULL>	Patients with actinic cheilosis classified as grades III or IV as previously described; Over the age of 30 years; White skinned	The presence of other lesions in lip vermilion in addition to solar cheilitis; Immunosuppression such as transplanted or infected with HIV patients; Any type of treatment for actinic cheilosis in the last six months (except with sunscreen and lip balms; Known allergy to imiquimod or fludroxycortide; Pregnancy or breastfeeding; Histopathological diagnosis of carcinoma in situ or invasive squamous cell carcinoma; History of radiotherapy in the head and neck region; Any condition that may compromise the collaboration in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-5vktsgj	Multicomponent Exercises and their relationship with Intrinsic Capacity and Frailty	Not yet recruiting	Intervention	2023-10-11	<NULL>	<NULL>	6500	Intrinsic Capacity and Frailty: an intervention with Multicomponent Exercises based on the integrated care for the elderly – Icope of the World Health Organization	<NULL>	0, randomized-controlled, triple-blind	0	<NULL>	<NULL>	<NULL>	2023-10-20	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5vktsgj	<NULL>	Persons aged 60 years or older; Both sexes; Enrolled in the School Health Center; Under elective follow-up with the health team at the study site; Living at home; Which presents the impaired mobility domain in the intrinsic capacity screening; Have access to a mobile phone with internet to participate in the proposed intervention; Who has a family member and/or caregiver to accompany/supervise the performance of the exercises	Inability to perform the Short Physical Performance Battery test; Insanity; Severe hearing or visual impairment; Illness causing severe functional limitation (Barthel less than 20); Permanent or temporary inability to walk; Amputation of limbs; Aphasia and loss of strength caused by a stroke; Hospital admission in the last three months for any reason; Diagnosis of cancer with active chemotherapy or radiotherapy treatment; Score less than &lt; 20 points on the Mini Mental State Examination (MMSE); Performing physical exercises in daily life.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-4fzty8p	Use of Laser Therapy to prevent complications in people with Diabetes	Recruitment completed	Intervention	2023-10-11	<NULL>	<NULL>	6501	Effectiveness of Low-intension Laser Therapy in the prevention of complications in lower limbs of people with Diabetes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-15	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-4fzty8p	<NULL>	Having type I or type II DM with diabetic peripheral neuropathy; presenting sensory alterations; reporting burning pain with paresthesia in one or both lower extremities; being aged between 30 and 70 years	Have foot ulcers; have serious complications of diabetes mellitus (target organ damage, diabetic ketoacidosis, hypoglycemia and chronic cardiovascular diseases); have neurological deficiencies not associated with diabetes; have thyroid dysfunction; be pregnant, have a metal implant in the body; abuse drugs; have cancer; and to use a wheelchair	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-96d7ym7	The effect of Vaginal Dilator and Perineal Massage techniques in women with sexual pain	Terminated	Intervention	2023-10-11	<NULL>	<NULL>	7625	Effect of adding Vaginal Dilators to the Perineal Massage technique in women with Genito-Pelvic/Penetration pain: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-08	Faculdade de Educação Física e Fisioterapia - Universidade Federal de Uberlândia	Faculdade de Educação Física e Fisioterapia - Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-96d7ym7	<NULL>	Women over 18 years of age; who have had sexual intercourse with vaginal penetration; who have genito-pelvic/penetration pain disorder before during or after sexual intercourse	Women who do not tolerate the introduction of a finger into the vaginal introitus; pregnant women; pelvic inflammatory disease; women after pelvic radiotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-2trzh45	Adjunct effect of Transdermal Systemic Photobiomodulation in Alveolar Bone Graft Surgery	Terminated	Intervention	2023-10-10	<NULL>	<NULL>	6495	Adjunctive effect of Systemic or Point Laser in Secondary Alveolar Bone Graft Surgery	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	Faculdade de Odontologia de Bauru, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2trzh45	<NULL>	Have a bilateral transforamen cleft and be able to undergo secondary or tertiary alveolar bone graft surgery with a donor area from the iliac crest	Do not accept participation in the research and/or withdraw from any of its stages; positive test for SARS-cov 2; Modifications in the surgical plan at the time of surgery; presence of a beard or mustache at the time of image acquisition, in order not to compromise the analysis of facial temperature; black patients due to the presence of a greater amount of melanin on the surface of the skin, since the red laser is absorbed by this chromophore and may cause burns with the dose used and standardized for research participants; patients with systemic compromise and not suitable for surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-48wwhsw	Evaluation of the effect of venous anesthesia during Gallbladder Removal Surgery on pain intensity and acute inflammatory response	Data analysis completed	Intervention	2023-10-10	<NULL>	<NULL>	6496	Evaluation of the effect of intraoperative venous Lidocaine on pain intensity and plasma interleukin-6 (IL-6) concentration in patients undergoing Laparoscopic Cholecystectomy	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-12-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-48wwhsw	<NULL>	Patients over 18 years of age, ASA I-III, of both genders, who underwent videolaparoscopic cholecystectomies were included in the study.	Patients who had cardiac arrhythmias, dilated cardiomyopathy, cardiac conduction disorders, electrolyte disorders, acid-base disorders, hypersensitivity to lidocaine, psychiatric, liver, respiratory or oncological diseases, who had been receiving any type of analgesic in the previous week were excluded from the study, surgery and those who received blood products during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-6yp5vsr	Increased index finger strength induced by a overflow of strength from the contralateral shoulder musculature	Not yet recruiting	Intervention	2023-10-10	<NULL>	<NULL>	6497	Increase in index finger flexion strength induced by overflow contralateral to isometric contraction of the shoulder abductor muscle	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-11-06	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Centro Universitário Padre Albino	https://ensaiosclinicos.gov.br/rg/RBR-6yp5vsr	<NULL>	Both sexes; age group from 18 to 30 years old; motor preference for the right upper limb	Presenting any orthopedic alteration or pain that hinders the execution of the movement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-5k9fz6d	Palliative care: competencies among medicine students in Brazil	Not yet recruiting	Observational	2023-10-09	<NULL>	<NULL>	6490	Palliative Care: Competencies among medicine students in Brazil, a Cross-Sectional Study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-5k9fz6d	<NULL>	All students regularly enrolled in the medical course in Brazil and of legal age who wish to participate in the research will be invited and included.	Minors and those who present some limitation to answer questionnaires will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-38vv8zz	Effect of Stretching Exercises on occupational stress, manual strength and walking in seamstresses: a	Recruitment completed	Intervention	2023-10-09	<NULL>	<NULL>	6491	Impact of the practice of Stretching Exercises on occupational stress and physical capacity of workers:	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-31	Patrícia nascimento de almeida oliveira	Programa de pós-graduação em ciências do exercício e do esporte/ Universidade estadual do rio de janeiro	https://ensaiosclinicos.gov.br/rg/RBR-38vv8zz	<NULL>	Who act as table seamstresses; That they do not have intellectual and/or motor limitations that prevent them from carrying out the proposed exercises and tests; in addition to providing their consent to participate in the research	Pregnant participants who are not able to practice physical exercises; according to medical indications; Collaborators who are on vacation scheduled for the study period and; Those who are away from their work activities or who are complying with prior notice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-4xtk65g	Hormonal, bone mass and lean muscle evaluation in patients after high-dose chemotherapy for autologous hematopoietic stem cell transplantation for Lymphoma	Recruiting	Observational	2023-10-09	<NULL>	<NULL>	6493	Hormonal evaluation, bone mass and Sarcopenia in patients after high-dose chemotherapy for autologous hematopoietic stem cell transplantation for Lymphoma	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-05-06	Christianne Leal	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4xtk65g	<NULL>	Patients volunteers between 18 and 70 years old who underwent autologous hematopoietic stem cell transplantation for lymphoma and wanted to participate in the research by signing the informed consent form	Age &lt; 18 years old and &gt; 70 years old and people that do not want to be included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-67jth2z	Analysis of genetic molecules and cells for Tuberculosis identification and prediction	Recruiting	Observational	2023-10-09	<NULL>	<NULL>	6494	Evaluation of molecular and cellular markers for Tuberculosis diagnosis and prognosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-13	Instituto Gonçalo Moniz (IGM) da Fundação Oswaldo Cruz (FIOCRUZ)	Instituto Gonçalo Moniz (IGM) da Fundação Oswaldo Cruz (FIOCRUZ)	https://ensaiosclinicos.gov.br/rg/RBR-67jth2z	<NULL>	Participants with respiratory symptoms; men and women aged between 18 and 65 years (including) at the moment of informed consent; respiratory symptoms as a reason for seeking assistance at the Octávio Mangabeira Specialized Hospital (HEOM). Healthy participants; men and women aged between 18 and 65 years (inclusive) at the time of informed consent; postgraduate students, technicians, and/or researchers from the Gonçalo Moniz Institute (IGM), Fiocruz-Ba; absence of respiratory symptoms or acute illnesses in the last 14 days.	Participants with respiratory symptoms; individuals under 18 years old and over 65 years old; using systemic corticosteroids; who have had a previous diagnosis and/or treatment for pulmonary TB in the last two years; transplant recipients, undergoing cancer treatment, or having autoimmune diseases. Healthy participants; presence of respiratory symptoms or acute illnesses in the last 14 days; previous diagnosis and/or treatment for pulmonary TB in the last two years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-3vmy6sq	Effectiveness of Routine Outcome Monitoring in Psychotherapy in the period of the COVID-19 pandemic	Data analysis completed	Intervention	2023-10-06	<NULL>	<NULL>	6487	Evaluation of the effectiveness of Psychotherapy in the period of the COVID-19 pandemic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	APHETO - Laboratório de Psicopatologia e Clínica Humanista Fenomenológica	Serviço de Psicologia Aplicada (SPA)	https://ensaiosclinicos.gov.br/rg/RBR-3vmy6sq	<NULL>	Persons over 18 years of age; Be registered with the Unified Health System (SUS); Be regulated in the SPA-NAMI system (study site); Present emotional distress in the COVID-19 pandemic period, through self-report in screening; Have availability for weekly psychotherapeutic care, with an average duration of 50 minutes, for six months remote or in person; Possess cognitive ability that allows the understanding and completion of the OQ®-45.2 and OQ®-ASC research instruments	Participants who were experiencing a severe emotional crisis related to a moderate or severe psychiatric disorder, which made systematic psychotherapeutic follow-up impossible; Patients who were already undergoing psychotherapeutic follow-up with another professional	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-10gcjj55	The need for Antibiotic Prophylaxis Therapy in the Extraction of third molars from healthy patients	Recruiting	Intervention	2023-10-06	<NULL>	<NULL>	6488	Prospective evaluation of the need for Antibiotic Prophylaxis Therapy in the tooth Extraction from healthy patients	<NULL>	2-3, non-randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2022-07-16	Faculdade de Odontologia da Universidade Federal de Uberlândia	Hospital Odontológico da Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10gcjj55	<NULL>	Volunteers aged 18 and over; both genders; with at least 1 mandibular third molar to be extracted under local anesthesia - indications for extraction in this study will be any third molar, impacted or not, with or without limited space for eruption, or extraction indicated for any other reason in accordance with the criteria from the Oral and Maxilo Facial Surgery Department (CTBMF)	Age under 18; poor oral conditions; pregnant women; systemic illnes; inflammation or infection at the extraction sites; current use of other antibiotic therapy; immunosuppression; gastrointestinal bleeding or ulceration; cardiovascular and kidney diseases; and any allergies to the local anesthetic (Alphacaine 100, DFL, Brazil - 2% Lidocaina HCl with 1:100,000 Epinephrine); Nimesulide or other nonsteroidal anti-inflammatory drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-3sbp54z	Action of water with ozone in dental implant surgery to reduce pain, swelling and difficulty opening the mouth	Recruiting	Intervention	2023-10-06	<NULL>	<NULL>	6489	Effect of using ozonated water during dental implant surgery on the control of healing, pain, edema and trismus: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-10	Faculdade Unidas do Norte de Minas	Faculdades Unidas do Norte de Minas - FUNORTE	https://ensaiosclinicos.gov.br/rg/RBR-3sbp54z	<NULL>	Patients over the age of 18 years; both gendres; without impairment of general health according to medical history and physical examination; patients with indication of placement of dental implants in the region of bilateral mandibular molars selected through clinical and radiographic examination	Patients classified as American Society of Anesthesiology (ASA) III or American Society of Anesthesiology (ASA) IV; use of anti-inflammatory drugs within 15 days prior to surgery; submitted to antibiotic therapy in the last 2 months; patients with tuberculosis, leukocytosis, collagen vascular diseases, multiple sclerosis, HIV infection, and other autoimmune diseases; pregnant and lactating women; patients with cognitive disorders that make it impossible to understand and execute commands; withdrawal of consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-9ycg67p	Laser to control Anxiety during Third Molar Extraction	Not yet recruiting	Intervention	2023-10-05	<NULL>	<NULL>	6485	Intravascular Laser Irradiation of Blood (ILIB) to control Anxiety in patients undergoing Lower Third Molar Extraction: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Universidade Evangélica de Goiás	Universidade Evangélica de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9ycg67p	<NULL>	Patients who agree to participate in the study and sign the free and informed consent form; older than 18 years; both genders; ASA classification I or II (American Society of Anesthesiologists, 2023), who have not previously undergone third molar extraction; indication of extraction of at least one lower third molar, with a moderate or minimally difficult level according to Pederson&apos;s classification	Patients with signs of infection or inflammation in the tissues adjacent to the teeth indicated for extraction; with psychiatric disorders; cognitive distortions that interfere with the application of the questionnaire; patients using anxiolytics or antidepressants; pregnant women; patients who do not have at least one radial artery available for Intravascular Laser Blood Irradiation (ILIB) therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-10p7wv9y	Change in electrical properties of leg muscle by stimulation of Systemic Acupuncture points	Not yet recruiting	Intervention	2023-10-05	<NULL>	<NULL>	7081	Change Dielectric Constant by stimulation of Systemic and Auricular Acupuncture points	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-06-30	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10p7wv9y	<NULL>	Healthy volunteers; both genders; age between 18 and 38 years	Fear of needles; pregnant women; women with delay in menstrual cycle longer than 28 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-3mcdzwg	Effect of practicing Auriculotherapy on tremors and motor symptoms in elderly people with Parkinson&apos;s disease: a case-control study	Not yet recruiting	Intervention	2023-10-04	<NULL>	<NULL>	6483	Effect of Auriculotherapy on the motor symptoms of elderly people with Parkinson&apos;s: Case-control study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade do Estado do Rio Grande do Norte	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3mcdzwg	<NULL>	Individuals over 60 years of age; of both sexes; with a diagnosis of Parkinson&apos;s disease with medical report by a neurologist, in regular outpatient follow-up; absence of other neurological disorders or comorbidities that could affect gait; absence of dementia; vision and hearing adequate or corrected to normality; be available to participate in activities and time availability for submission to intervention sessions	Individuals with uncompensated morbidities; having physical problems and/or impairments that could be aggravated during the intervention, such as a history of vestibular disease, psychiatric disorders, unilateral or bilateral hearing deficit; having a cognitive disorder; severe change in visual acuity and/or history of stroke; who have an infection, inflammation or injury to the ear; make use of piercing (except normal earring); refusal to receive auricular treatment using mustard seeds; not responding to three contact attempts made by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-73v6sqk	Social Skills Training and psychological distress in health students	Not yet recruiting	Intervention	2023-10-03	<NULL>	<NULL>	6479	Social Skills Training and psychological distress in health students: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Universidade Federal de Juiz de Fora - UFJF	Universidade Federal de Juiz de Fora - UFJF	https://ensaiosclinicos.gov.br/rg/RBR-73v6sqk	<NULL>	Students of the research target courses who present complaints related to difficulties in interpersonal relationships and symptoms of psychological distress. Minumim age 18 years. Both genders. Students who have or have not responded to the assessment protocol in the first study proposed in this project may participate. Indication of the need to participate in a Social Skills Training program (according to the score obtained in the Del-Prette Social Skills Inventory - IHS2-Del-Prette). Clinical indices of depression, generalized anxiety and/or social anxiety, according to the score obtained on the instruments used for such assessment	Those students who at the time of the pre-test are undergoing psychological and/or psychiatric treatment will not be included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-10nnzgqh	Clinical study to verify the effectiveness of two drugs to prevent inflammation of the Pancreas after performing the Endoscopic Retrograde Cholangiopancreatography procedure	Recruiting	Intervention	2023-10-03	<NULL>	<NULL>	6480	Prophylaxis for Acute Pancreatitis after Endoscopic Retrograde Cholangiopancreatography (ERCP): clinical, randomized, double-blind trial to evaluate the efficacy of Diclofenac versus Indomethacin and the benefit in risk groups	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-05-15	Faculdade de Medicina de Sao Jose do Rio Preto	Faculdade de Medicina de Sao Jose do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-10nnzgqh	<NULL>	Patients submitted to Endoscopic Retrograde Cholangiopancreatography; of both sexes; aged over 18 years	Patients under 18 years of age; pregnant women; nursing mothers; those who do not accept or are not able to perform the Endoscopic Retrograde Cholangiopancreatography Exam(s) and follow-up during the study; Patients who lost clinical and laboratory follow-up due to hospital transfer or early death from severe cholangitis; patients with Non-steroidal anti-inflammatory drugs (NSAID) allergy and contraindication for use (i.e., active peptic ulcer, serum creatinine &gt;1.4mg/dL, and single kidney) will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-10vpf9bm	Telehealth Intervention to improve Heart Failure care after hospital discharge	Not yet recruiting	Intervention	2023-10-03	<NULL>	<NULL>	6484	Digital Optimization Toolkit for management of Heart Failure after discharge	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-23	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-10vpf9bm	<NULL>	Age &gt;18 years; diagnosis of heart failure (HF) with left ventricular ejection fraction (LVEF) ≤50%, from Echocardiogram, Cardiac Magnetic Resonance Imaging or Myocardial Scintigraphy; hospitalization for HF with discharge scheduled for the next few days or recent hospitalization for HF with discharge less than 2 weeks ago; at least one medication of the conventional treatment (betablockers, ACEI/ARB/ARNI, MRA) not started or two medications among those with a prescribed dosage less than or equal to 50% of the target dose; and who agree to participate and sign the Informed Consent Form	CKD (chronic kidney disease) stage V; Previous heart transplant or active patient on the heart transplant list; Previous use of Ventricular assist device; Cardiac amyloidosis; Pregnant or planning to become pregnant; Estimated life expectancy of less than 6 months related to non-cardiac comorbidities according to the investigator&apos;s judgment; Defined as for palliative support; Current participation in another study to investigate devices or drugs, or have participated in another study in the last 30 days; Patient or caregiver who lives in the same household without access to Smartphone; Patient without cognitive conditions to make own decisions; Illiterate patients (do not know how to read and/or write) without a responsible caregiver; patient who for some reason will not be available to complete the procedures (eg interviews) established in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-2kvnqrm	Comparative evaluation of three different Gingival Grafts	Recruitment completed	Intervention	2023-10-03	<NULL>	<NULL>	6772	Comparative clinical study between conventional Free Gingival Grafts (EGL) and Inverted Free Gingival Connective Tissue Grafts (EGLCI), in split mouth: study in humans	<NULL>	array, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2017-07-19	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2kvnqrm	<NULL>	Healthy patients; both genders; non-smokers; 18 and 60 years old; absence of periodontal disease in the teeth of interest of the research; with indication of increase of the band of keratinized mucosa bilaterally in the region of at least 3 mandibular premolars.	Patients with systemic problems that contraindicate oral surgeries; pregnant women; who were taking or had taken controlled medications and antibiotics in the last 6 months preceding the survey, presence of periodontal disease in the areas of interest of the survey; cognitive impairment; users of illicit drugs or alcohol and smokers; former users of illicit drugs, former smokers and former alcoholics could only be included in the study if they had fully quit their addiction at least 6 months before the start of the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-10gn5jbj	Evaluation of the effectiveness of Psycho-educational Intervention in the treatment of disorders in the sexual performance in women: a randomized clinical trial	Recruiting	Intervention	2023-10-02	<NULL>	<NULL>	6476	Evaluation of the effectiveness of Psycho-educational Intervention in the treatment of Sexual Dysfunctions in women: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal do Maranhão	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10gn5jbj	<NULL>	sexually active women; 18 to 45 years old; with sexual dysfunction according to the FSFI instrument; score less than or equal 26	women under the age of 18 who has any of the following morbidities;Diabetes; arterial hypertension; thyroid diseases such as neuropathies; depression; hyperprolactinemia; hypoandrogenism; vaginismus; or use of benzodiazepines; antidepressants; antidopaminergic antipsychotics; antiandrogens; beta adrenergic blockers;  centrally acting antihypertensives; histamine H2 blockers ; or that report the presence of a third persons at the place of sexual intercourse	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-4g4jkrw	Phase I clinical study of Bacterial nanocellulose membranes modified with Poly-l-lisine-cholesterol	Recruitment completed	Intervention	2023-10-02	<NULL>	<NULL>	6477	Safety study of topical application of bacterial Nanocellulose membranes with surface modification: phase 1 clinical trial	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2022-05-01	Faculdade de Enfermagem - Universidade Federal de Juiz de Fora	Faculdade de Enfermagem - Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4g4jkrw	<NULL>	Adults aged above 18 and below 60 years; of both sexes	Adults without a history of infectious or parasitic diseases, infectious processes, or allergy to the components of the formulation;  without the use of antimicrobials, immunosuppressants, systemic corticosteroids, and antiallergic and anti-inflammatory drugs in the last 15 days;  pregnancy and breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-10zj27p5	Evaluation of the effectiveness of a Pain Monitor for the adequacy of Analgesia in the perioperative period of Stomach Reduction surgery	Recruiting	Intervention	2023-10-02	<NULL>	<NULL>	6478	Evaluation of the effectiveness of a Nociception Monitor for the adequacy of Analgesia in the perioperative period of Gastroplasties	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-09	Fundação do ABC	Fundação do ABC	https://ensaiosclinicos.gov.br/rg/RBR-10zj27p5	<NULL>	Adult men and women will be included; aged between 18 and 65 years; diagnosed with obesity who will undergo gastroplasty by videolaparoscopy&apos; who agree to participate in the research after signing the free and informed consent form	Any patient who does not agree to participate in the study; ASA 3 or 4; previous use of opioids or illicit drugs; has a diagnosis of chronic pain; oncological diseases; history of cognitive psychiatric renal or neurological disorders; contraindication or allergy to any drug to be used in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-10b6jdy3	Effects of Post-Exercise Water intake on cardiac contractions in cirrhotic patients	Recruitment completed	Intervention	2023-10-02	<NULL>	<NULL>	7837	Effects of Water Intake on Post-Exercise vagal reactivation in cirrhotic patients	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2025-02-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10b6jdy3	<NULL>	Participants with liver cirrhosis;classified by the Child-Pugh scale A, B and C;over 18 years of age;of both sexes;heart rate in sinus rhythm; and who have performed;hepatic elastography within a maximum time of 12 months from the collection date.	Participants with any musculoskeletal limitation that could interfere with the experimental procedures; patients with a cardiac pacemaker; hyponatremia with values below 142 mEq/L; diagnosis of hepatocellular carcinoma and encephalopathy with a grade equal to or greater than 2; with known respiratory diseases prior to data collection; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:34
RBR-53trrwk	Effects of graded exercise in pain processing in patients with knee arthrosis	Recruiting	Intervention	2023-10-01	<NULL>	<NULL>	6471	Effects of graded exercise in pain processing in patients with knee Osteoarthritis: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-26	Programa de Pós-Graduação em Fisioterapia, Departamento de Fisioterapia, Universidade Federal de São Carlos	Hospital Universitário da Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-53trrwk	<NULL>	40 years or older,both sexes, clinical (American College of Rheumatology) and/or radiological (K/L II, III or IV) diagnosis of knee osteoartritis, pain as a primary symptom, mean pain intensity ≥ 4 on numerical pain scale (NPS) in the 7 days before the evaluation	"Trauma or muscle damage, physiotherapy (more than once a week), regular physical activity (≥ 150 minutes per week), corticosteroid infiltration in last 30 days, history of knee surgery(s), rheumatic diseases, chronic painful syndromes, peripheral neuropathy, motor deficit, neuromuscular diseases, severe or uncontrolled cardiovascular diseases, health conditions that risk the safety of participants,
pregnancy, recent history of substance dependence, inability to understand and follow instructions, inability to move without outside assistance, and initiation of treatment programs during"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-3z839h9	Quality of life after nutritional orientation for patients with cardiovascular disease	Recruiting	Intervention	2023-10-01	<NULL>	<NULL>	6472	Nutritional orientation for patients in cardiovascular rehabilitation and quality of life	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-05	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3z839h9	<NULL>	"The sample of this study will consist of individuals seen at the cardiovascular rehabilitation service of the Jenny Faria outpatient clinic at the Hospital das Clínicas of the Federal University of Minas Gerais. Participants will be recruited upon referral by the physician and/or the physiotherapy team.
The study will include patients who are undergoing follow-up with the medical and/or physical therapy team of cardiovascular rehabilitation, aged over 18 years, who have the ability to understand and have a clinical status compatible with the performance of the procedures."	Individuals who are under current nutritional monitoring and who do not demonstrate interest in participating in the study will not be included in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-6p83pjb	Effects of fortified protein supplementation and influence of single nucleotide polymorphisms: nutritional status and food behavior of patients underwent to bariatric surgery	Recruiting	Intervention	2023-10-01	<NULL>	<NULL>	6473	Nutritional status and eating behavior of patients undergoing bariatric surgery: effects of fortified protein supplementation and influence of nucleotide polymorphism	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-07	Universidade Federal de Goiás	Hospital Geral de Goiânia Doutor Alberto Rassi	https://ensaiosclinicos.gov.br/rg/RBR-6p83pjb	<NULL>	Women undergoing bariatric surgery, aged between 18 and 65 years; women; body mass index greater than or equal to 40 kilograms per cubic meter; body mass index greater than or equal to 35 kilograms per cubic meter associated with comorbidities	Women in pregnancy or lactation; volunteers in a situation of tobacco or nicotine dependence; situation of chronic abuse of alcohol and/or illicit drugs; confirmed diagnosis of severe or moderate psychotic or dementia conditions; previous history of bariatric surgery; have an allergy or intolerance to any component of food supplement formulas; be vegan or vegetarian; have any dietary restrictions regarding the consumption of whey protein; previously using some type of food supplement; be participating in another research protocol involving dietary supplementation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-10xv7t6b	Skin cleansing soap with Candida auris: clinical trial to evaluate safety and efficacy	Not yet recruiting	Intervention	2023-10-01	<NULL>	<NULL>	6474	Cutaneous antiseptic for Candida auris decolonization: randomized double-blind clinical trial to evaluate safety and efficacy	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-12-01	Centro de Ciências Médicas da Universidade Federal de Pernambuco	Hospital da Restauração de Pernambuco Governador Paulo Guerra	https://ensaiosclinicos.gov.br/rg/RBR-10xv7t6b	<NULL>	Patients hospitalized in the Intensive Care Units of the Hospital da Restauração who have skin colonization with Candida auris confirmed by the hospital&apos;s clinical analysis laboratory, aged 18 years or older, without limitation of gender and race and who have signed the Term of Free and Informed Consent - TCLE	Patients with a previous diagnosis of superficial or invasive mycosis and who are using antifungal therapies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-5y44mmj	Evaluation of retinal thickness in patients with Glaucoma using Prostaglandin eye drops undergoing Trabeculectomy surgery	Recruitment completed	Intervention	2023-09-30	<NULL>	<NULL>	6470	Evaluation of Macular Thickness in patients with Glaucoma in use of Prostaglandin Analogue undergoing  Trabeculectomy with Mitomycin C	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Federal de Goiás	Fundação Banco de Olhos de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-5y44mmj	<NULL>	"Pacients of all ages with Primary Glaucoma; Primary Open Angle Glaucoma; Primary Narrow Angle Glaucoma; Normal Pressure Glaucoma; Pigmentary Glaucoma; Pseudoexfoliative Glaucoma; visual field changes; typical defect compatible with glaucomatous lesion and/or typical anatomical involvement of the optic disc or nerve fiber layer of the retina (such as Hoyt´s sign,  cupping ratio greater than 0.7, localized neural rhyme defect, or cupping asymmetry); indication of trabeculectomy at medical discretion (example: uncontrolled intraocular pressure or impossibility of using medication due to allergy or financial conditions); need to reduce the intraocular pressure by at least 20% in relation 
 to the baseline in the postoperative period for inclusion; intraocular pressure above the traget established for the case and with medication"	Any pathology that could interfere with the results of the tests; low quality of exams; any previous macular pathology; use of diamox; advanced glaucoma with maximal  therapy; advanced glaucoma with impaired fixation; any surgical complications including hypotonia in any evaluation; performing combined cataract and glaucoma surgery; need for surgical intervention; reintrodution of therapy with prostaglandin analogues	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-75v8pxk	Effectiveness of an Eye Patch for preventing Corneal Injury in intensive care unit patients: an interventional study	Not yet recruiting	Intervention	2023-09-29	<NULL>	<NULL>	6469	Effectiveness of a Polyethylene Chamber for the prevention of Corneal Injury in sedated and mechanically ventilated patients: a randomized clinical trial	<NULL>	array, randomized-controlled, double-blind	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-06	Universidade Federal do Acre- UFAC	Universidade Federal do Acre- UFAC	https://ensaiosclinicos.gov.br/rg/RBR-75v8pxk	<NULL>	Adult and elderly patientssedated and on mechanical ventilation from the Intensive Care Unit	Patients hospitalized for less than 48 hours or with corneal injury on admission	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-2n2nfp6	Acrylic splints for treating chronic muscle pain in patients with TMD: randomized clinical trial	Not yet recruiting	Intervention	2023-09-28	<NULL>	<NULL>	6467	Total and partial splints in the treatment of chronic myalgia in patients with TMD: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-2n2nfp6	<NULL>	Having myalgias related to Temporomandibular Disorders (TMDs) for longer than 6 months; myalgias located in the temporal region accompanied, or not, by other facial myalgias; be aged 18 years or over; both genders; pain on palpation with a score greater than or equal to 7 on the numeric rating scale; pain related to functional and/or parafunctional activities of the stomatognathic system	Patient undergoing physiotherapeutic and/or speech therapy treatments that have repercussions on muscle, joint and/or skeletal structures in the head and neck region; who have undergone some type of temporomandibular joint procedure in the last 12 months; patients with facial paralysis; patients undergoing orthodontic treatment; complete denture users; who underwent a procedure using botulinum toxin in the head and neck region in the last 6 months; patients using Selective Serotonin Reuptake Inhibitors (SSRI) antidepressants; patients undergoing psychological treatment; patients who have cognitive and/or neuromotor difficulties that compromise the stages of the study&apos;s development	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-9t57jvr	Evaluation of the effects of Orthognathic Surgery on Quality of Life and Sleep Quality	Recruiting	Observational	2023-09-28	<NULL>	<NULL>	6468	Evaluation of the effects of Orthognatic Surgery on Quality of Life and parameters for Assessing Sleep Quality	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-9t57jvr	<NULL>	Patients from the Orthognathic Surgery Outpatient Clinic of the State University of Maringá (UEM) who underwent orthognathic surgery of the jaws between 2022 and 2023 (patients who were already going to undergo the surgery, regardless of our research) that we were able to follow up with at least , 3 months postoperatively; patients of both sexes; aged between 18 and 60 years; with or without a previous diagnosis of Obstructive Sleep Apnea and Hypopnea Syndrome (OSAS)	Patients using continuous positive airway pressure (CPAP); patients using an intraoral appliance for obstructive sleep apnea; patients with craniofacial syndromes; patients with clinical conditions of chronic obstructive pulmonary disease, hypothermia, vasoconstriction, hypovolemia, peripheral vascular disease and anemia; patients with a previous history of orthognathic surgery or any other type of airway surgery; patients who underwent some type of additional treatment for Obstructive Sleep Apnea and Hypopnea Syndrome (OSAS) between the evaluated periods; patients who made continuous use of medications such as: sleep inducers, sedatives, muscle relaxants and anxiolytics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-33hrzwh	Complications of exodontia	Recruiting	Observational	2023-09-26	<NULL>	<NULL>	6461	Discomforts and complications associated with dental extraction surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-10	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-33hrzwh	<NULL>	Dental extractions as part of routine dental procedures, with precise indication for their execution. Urgeries of non-impacted or included third molars with short and convergent roots. Consent to participate in the research and sign the informed consent form.	Pediatric patients with surgeries indicated for deciduous teeth. Surgeries of included third molars or with any degree of bone impaction. Patients under 18 years of age with an indication for dental extraction, without the presence and consent of a legal guardian.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-38trvv9	Evaluation of maxilla, mandible and nose size among participants with Cleft Lip compared to participants without Cleft Lip	Not yet recruiting	Intervention	2023-09-26	<NULL>	<NULL>	6462	Evaluation of the maxillomandibular and nasal proportion of participants with Cleft Lip and Palate compared to normotypical participants	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Hospital da Baleia	https://ensaiosclinicos.gov.br/rg/RBR-38trvv9	<NULL>	Non-syndromic individuals with unilateral or bilateral cleft lip and palate; individuals born up to 3 weeks old (control and to be treated with NAM); individuals aged up to 2 years (groups not treated with NAM – pre and post surgical follow-up); male and female babies individuals with no cleft lip and palate (control group); individuals without a medical history of recurrent middle ear otitis; individuals whose parents and/or guardians agree to participate in the study and sign the TCLE; individuals whose parents or guardians are of legal age	Cleft individuals with other systemic diseases; participants with incomplete cleft lip and palate; individuals who have already undergone palate repair surgery; individuals using topical or systemic antibiotics or corticosteroids, individuals whose parents or guardians are minors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-108zwbzy	Use of Acupuncture in the health center of the Federal University of Ouro Preto/basic health unit Bauxita-Ouro Preto-MG like model for the treatment: evaluation of pain and inflammation in temporomandibular disorders in human	Data analysis completed	Intervention	2023-09-26	<NULL>	<NULL>	6463	Implementation of Acupuncture in the health center of the Federal University of Ouro Preto/basic health unit Bauxita-Ouro Preto-MG with proposal of guidelines for the treatment: subjective, biochemical and physical evaluation of pain and inflammation in temporomandibular disorders in human model	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-108zwbzy	<NULL>	female; age range 20 to 59 years; orofacial pain; being more than 3 months without receiving treatment with acupuncture or for temporomandibular dysfunction	pregnant women; active cancer; fear of needles; undergoing acupuncture treatment; taking pain medication; pain from trauma; wearing an orthodontic appliance; wearing an occlusal plate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-8yq5b8h	Treatment of dentin hypersensitivity with 5% sodium fluoride varnish, low level laser therapy and associated application: randomized split-mouth clinical study	Data analysis completed	Intervention	2023-09-26	<NULL>	<NULL>	6464	Treatment of dentin hypersensitivity with 5% sodium fluoride varnish, low level laser therapy and associated application: a clinical, controlled, randomized, split-mouth study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2017-07-10	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8yq5b8h	<NULL>	Healthy volunteers; male or female aged between 20 and 65 years; with healthy periodontium; no periodontitis or gingivitis; presenting teeth without the presence of caries, cracks, fractures or extensive restorations; presenting teeth without premature contact; volunteers who have understood the study design; volunteers who have at least four sensitive teeth in their mouths, one in each oral quadrant; volunteers who have signed and agreed to the Informed Consent Form	Pregnant or breastfeeding women; subjects registered in another clinical trial; individuals who underwent professional treatment for hypersensitivity, or who used desensitizing products in the 3 months preceding the research period; history of maxillofacial cancer in the last 5 years; need for systemic treatment due to infection; patients who make chronic use of anti-inflammatory drugs, analgesics or psychotropic drugs; individuals who have allergies or who have some idiosyncratic response to any component of the product used in the research; patients who present parafunctional habits, eating disorders, gastric or emotional illness that is predisposed to dentin sensitivity; advanced medical or psychological illness; alcohol consumption or drug intoxication; hemorrhagic disease; systemic condition that is an etiological or predisposing factor for dentin sensitivity; diet with excessive exposure to acidic foods; individuals who underwent periodontal surgery or orthodontic treatment in the preceding 3 months; dental or periodontal pathologies, or defects that cause pain, such as caries, “brackets”, and extensive fillings; teeth that serve as &quot;abutments&quot; or support for fixed or removable dentures, or that have crowns; teeth with restorations that extend to the test area (cervical); teeth with irreversible pulp inflammation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-10tgxp8n	The influence of elastic bandage on knee pain and function in women with Patellofemoral pain syndrome	Data analysis completed	Intervention	2023-09-26	<NULL>	<NULL>	6465	Analysis of the influence of elastic bandage on quadriceps muscle performance in women with Patellofemoral pain syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Universidade Norte do Paraná	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10tgxp8n	<NULL>	Be between 18 and 35 years old, be female. Present pain in the anterior region of the knee for at least three months and refer pain in three of the functional activities such as squatting, jumping, climbing and descending stairs, kneeling, running or sitting for a long time. (McConnel, 1996), pain on palpation in the medial or lateral region of the patella, pain level on the Visual Analog Scale is greater than or equal to three, as suggested by Mostamand et al. (2011), BMI less than 29.9kg/m²	Physical or mental disability, use of assistive walking devices, history of orthopedic surgery or use of orthosis/prosthesis, allergy to elastic bandage, history of severe knee injury (ligaments, menisci or tendon tears), neurological, rheumatic or cardiovascular diseases that make it impossible to carry out the proposed activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-5whgypj	Physical training to the heart of frail elderly	Recruitment completed	Intervention	2023-09-26	<NULL>	<NULL>	6466	Effect of Physical Training with Handgrip on cardiovascular autonomic control and characterization of frailty syndrome in the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-11	Universidade Anhembi Morumbi	Universidade Anhembi Morumbi	https://ensaiosclinicos.gov.br/rg/RBR-5whgypj	<NULL>	Elderly people aged 60 years or older; of both sexes; members of one of the groups of elderly people at the Integrated Health Center at Universidade Anhembi Morumbi; who agree to participate in the study and sign the free consent form, will be included in the research	Elderly people who present any criteria that change the autonomic assessment (atrial fibrillation and use of beta-blockers), who do not agree to participate in the study or who present any criteria that impair their participation in the protocol, such as intolerance to exams or withdrawal due to part of the patient	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-8t7h259	Effects of Gamma Aminobutyric Acid associated with Physical Exercise in Sedentary women	Recruitment completed	Intervention	2023-09-25	<NULL>	<NULL>	6460	GABA Phytotherapeutic for Strength Exercise practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-18	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-8t7h259	<NULL>	Women, aged 18 years or older; Body Mass Index (BMI) equal to or greater than 25; sedentary for at least three months	Use of medications or supplements for weight loss or hypertrophy, receive nutritional guidance and start using medications that could interfere with the results of the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-73fdfq5	Treatment of Chikungunya Arthritis	Recruitment completed	Intervention	2023-09-25	<NULL>	<NULL>	7505	Treatment of Chikungunya Arthritis with Methotrexate and Dexamethasone: a randomized, triple-blind, placebo-controlled clinical trial	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2022-10-07	José Kennedy Amaral Pereira	Instituto de Medicina Diagnóstica do Cariri	https://ensaiosclinicos.gov.br/rg/RBR-73fdfq5	<NULL>	Inclusion Criteria; Men and women; from 18 to 90 years old; Able to provide informed consent; Laboratory confirmation of chikungunya virus infection (IgG or IgM serology or RT-PCR); New inflammatory arthritis that affects at least one joint; For women of childbearing age; a negative pregnancy test before starting treatment; Note Due to the risk to the child during MTX therapy, in addition to the initial pregnancy test being negative; women must agree to use contraceptive methods during treatment; As well as not intending to become pregnant during treatment	Exclusion criteria; Pre-existing history of inflammatory or non-inflammatory arthritis, or If there is a pre-existing history of arthritis, there must be new inflammatory arthritis affecting at least one joint; Contraindication to MTX therapy; including history of MTX hypersensitivity; pre-existing liver disease, abnormal liver function tests (greater than 2 times normal), significant alcohol consumption, stomatitis, haematological abnormalities, pulmonary fibrosis, renal failure (serum creatinine &gt; 1.5); current or past history of chronic infection; or treatment with any other immunomodulatory drug; Pregnancy or refusal to use contraceptive methods during the treatment phase.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:23
RBR-8ksffhm	Evaluation of Irradiation over the radial artery with Low-Intensity Laser as a method for controlling Oral Mucositis in patients undergoing Radiotherapy	Recruiting	Intervention	2023-09-22	<NULL>	<NULL>	6459	Evaluation of Transcutaneous Irradiation over the radial artery with Low-Intensity Laser as an additional method for the control of Oral Mucositis in patients undergoing Head and Neck Radiotherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-05	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-8ksffhm	<NULL>	patients over 18 years old; diagnosis of head and neck cancer; indication of radiotherapy treatment	Radiotherapy treatment with a dose lower than 50Gy in the primary treatment area; patients with neurological, psychomotor and/or psychiatric disorders; patients with neoplasia in the region to be irradiated; with undiagnosed clinical lesions in the irradiated region; on the skin of patients who make topical use of photosensitive substances; patients with complex arrhythmias and heart failure; patients with hematological neoplasms; patients with uncontrolled glaucoma; cataracts without medical supervision; pregnant patients; patients with tattoos in the region to be applied the laser	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-10zrb5sh	Effect of Aerobic Eexercise at different times of day on severity of obstructive sleep apnea, blood pressure and cardiac autonomic modulation in Obstructive Sleep Apnea patients	Recruiting	Intervention	2023-09-22	<NULL>	<NULL>	7172	Effect of Moderate Intensity Aerobic Exercise sessions prescribed at different times of day on severity of Obstructive Sleep Apnea, blood pressure and cardiac autonomic modulation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Complexo Hospitalar Hospital Universitário Oswaldo Cruz - HUOC/Pronto-Socorro Cardiológico de Pernambuco - PROCAPE	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10zrb5sh	<NULL>	Prior diagnosis of Obstructive Sleep Apnea - OSA (apnea hipopnea index above five events/hour); overweight; be aged above eighteen years; both genders	Having uncontrolled high blood pressure; cerebrovascular disease; kidney failure; arrhythmias; musculoskeletal limitations that compromise exercise performance; adhere to another treatment for Obstructive Sleep Apnea - OSA; did not complete the four experimental sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-7rppdgs	Cupping Therapy in Fibromyalgia	Recruitment completed	Intervention	2023-09-21	<NULL>	<NULL>	6456	Effect of Cupping Therapy on flexibility, functionality, pain and quality of life in Fibromyalgia Patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Adriana Teresa Silva	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-7rppdgs	<NULL>	Age between 30 and 65 years old; female and presenting the clinical diagnosis with fibromyalgia syndrome;; for more than three consecutive months; which was based on the diagnostic criteria of the American College of Rheumatology (2010); accept to participate and sign the Informed Consent Term (TCLE)	Patients who had dermatological disorders at the application site; presence of deep venous thrombosis;  presence of central and peripheral nervous system injury; orthopedic surgeries performed at the application site and did not accept signing the TLCE were excluded from the present study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-6yqjpv6	Blood flow restriction mobilization for prevention of acquired weakness	Not yet recruiting	Intervention	2023-09-21	<NULL>	<NULL>	6458	Kinesiological Ultrasonography analysis of early active and passive mobilization with blood flow restriction in the prevention of acquired weakness in patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-14	Universidade Estadual do Piauí - UESPI	Universidade Estadual do Piauí - UESPI	https://ensaiosclinicos.gov.br/rg/RBR-6yqjpv6	<NULL>	Adults over 18 years old.  Both genders. Hospitalization for more than 24 hours in the ICU ward. The stay must be at least 72 hours	Neuromuscular pathology. Osteoarticular contraindication to mobilization. Amputees. Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-2g9k29z	Non-Invasive Brain Stimulation performed during a donation task can modulate parts of the brain and emotional experience	Data analysis completed	Intervention	2023-09-20	<NULL>	<NULL>	6453	Exploring the neural correlates of charitable giving - a Non-Invasive Brain Stimulation Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-04-01	Instituto D&apos;Or de Pesquisa e Ensino	FAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2g9k29z	<NULL>	Healthy volunteers; both genders; nonsmokers; age between 18 and 50 years; undergraduate students or holders of a college degree	Personal history of epilepsy; cardiac pacemaker; previous intracranial surgery; pregnancy; regular psychotropics intake; inability to give informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-109k3fmj	Comparative study between Intrastromal Injection of autologous blood and C3F8 Injection for treatment of Corneal Hydrops	Recruiting	Intervention	2023-09-20	<NULL>	<NULL>	6454	Comparison between Intrastromal Injection of autologous blood and C3F8 Injection for the treatment of Severe Acute Corneal Hydrops	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-30	Universidade Federal de São Paulo	Departamento de Oftalmologia – Unifesp	https://ensaiosclinicos.gov.br/rg/RBR-109k3fmj	<NULL>	Patients older than ten years of age; both genders; patients who were clinically diagnosed with Acute Corneal Hydrops; patients who signed the medical consent term; availability for all the study visits	Having been submitted to ocular surgery in the last six months; presenting Hydrops condition for more than two months; occurrence or suspicion of occurrence of infectious episodes on the ocular surface; presence of Corneal Perforation or Atalamia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-6j4kw7q	Evaluation of analgesia provided by the use of Morphine or Methadone in women undergoing Laparoscopic Surgery	Not yet recruiting	Intervention	2023-09-20	<NULL>	<NULL>	6455	Morphine versus Methadone as postoperative analgesia in women undergoing Laparoscopic Surgery: a randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-6j4kw7q	<NULL>	Women undergoing clinical follow-up for gynecological pathologies at the Center for Integral Attention to Women&apos;s Health -  CAISM; 18 years or older, regardless of ethnicity or race; elective surgeries; laparoscopic surgery	Patients who have chronic pain; patients who are regularly using opioids; patients using illicit drugs; patients diagnosed with dementia; patients who do not understand the Portuguese language; patients with allergy to local anesthetics or to all non-steroidal anti-inflammatory drugs (ketoprofen, tenoxicam, diclofenac, dipyrone, paracetamol)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-5z54y8j	Protective mechanical ventilation in the transoperative period of orthognathic surgery in patients with cleft lip and palate	Recruitment completed	Intervention	2023-09-19	<NULL>	<NULL>	6448	Protective mechanical ventilation in the transoperative period of orthognathic surgery in patients with cleft lip and palate: protocol development and evaluation of lung expansion	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5z54y8j	<NULL>	Be aged between 18 and 50 years. Both sexes. Be in a position to perform orthognathic surgery, according to preoperative examinations and medical and surgical evaluation. No cognitive impairment, according to medical records. Not presenting any chronic pulmonary pathology pre-existing the surgery. No loss of blood volume greater than 1 liter. Do not exceed a Mechanical Ventilation time of more than 3 hours. No major intercurrences during the intraoperative period, such as bleeding, surgical time over 3 hours (180 minutes), airway difficult to intubate (malampat 4, short neck, deficiency in cervical extension); selective intubation	Patients who do not fit the inclusion items	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-75kq9s2	Clinical evaluation of bleaching efficacy, sensitivity, and oxygen level of the dental pulp when tooth bleaching with titanium dioxide nanoparticles associated with fluorine and nitrogen	Recruiting	Intervention	2023-09-19	<NULL>	<NULL>	6449	Clinical evaluation of bleaching efficacy, sensitivity, and pulp saturation level of bleaching treatments with titanium dioxide nanoparticles co-doped with fluorine and nitrogen	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-75kq9s2	<NULL>	Provide written and signed consent; Complete the vaccination schedule for COVID-19; Agree NOT to participate in another clinical trial during the course of the project; Present good general and oral health; Have not undergone dental bleaching in the last 3 years or have undergone it in the last 3 years, but have teeth darker than color A2; Having vital teeth in question (Positive response to the cold sensitivity test, absence of signs or symptoms of pulpal or periapical pathology, absence of radiographic signs of periapical pathology); No edentulous space between the premolars of each arch (upper and lower); Upper incisors must be classified as A2 or darker in color and free of caries and/or restoration; Age (over 18 and under 30); Being in treatment or other activities in FOP, not generating the need for exclusive visits for the research	Participating in another clinical trial; Presenting with a pre-existing medical condition (pregnant, lactating, smoking, or routine use of alcohol) or oral condition (non-vital teeth, dental caries in the region where the bleaching will be performed, need for endodontics, orthodontics or periodontal treatment and poor oral hygiene) that the investigator/examiner deems could put the individual at risk during the study; Have an adverse reaction to the materials used or a medical or dental history that could interfere with the progress of the study; Unable to attend appointments; The teeth in question have cracks or other defects that may increase the risk of pulpal toxicity; Is under treatment or needs periodontal treatment or caries; Have teeth lighter than color A2; Have extensive restorations on the teeth that will receive bleaching; Patient has a history of tooth sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-78rngkv	Effects of Exercise, Electrical muscle stimulation and Pain education on psychological, functional and muscular parameters of patients with low back pain, classified by risk of poor prognosis	Recruitment completed	Intervention	2023-09-19	<NULL>	<NULL>	6450	Effects of Lumbopelvic stabilization, Neuromuscular electrostimulation, Imagery, and Pain education on psychosocial, functional, and neuromuscular parameters of patients with Chronic low back pain, stratified by risk of poor prognosis: randomized clinical trial	<NULL>	array, randomized-controlled, single-blind	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-06	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-78rngkv	<NULL>	group control; age between 18 and 59 years; physically inactive; deny history of systemic diseases that limit or contraindicate the walk tests; or chronic or acute musculoskeletal disorders in the lower limbs and/or spine; chronic low back pain groups; age between 18 and 59 years; physically inactive; persistent low back pain for more than three months; physical characteristics compatible with mechanical etiology according to the evaluation and treatment guidelines proposed by the American College of Physicians and the American Pain Society	History of spinal surgery; pregnancy; lack of safe hemodynamic conditions for walking or clinical tests; significant increase in pain during the tests, making walking an intolerant activity according to the volunteer&apos;s perception; worsening of the chronic condition on the day of the test; symptoms of acute illnesses such as colds and flu; body mass index greater than 35.0	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-86fjm3h	Evaluation in the level of pain and color change in the Different Application Times of the In-office Bleaching	Terminated	Intervention	2023-09-19	<NULL>	<NULL>	6451	Evaluation of the efficacy and sensitivity of Applying Different In-office Whitening Times: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Universidade Salgado de Oliveira	Centro Universitário Maurício de Nassau	https://ensaiosclinicos.gov.br/rg/RBR-86fjm3h	<NULL>	"Any individual presenting interest in tooth bleaching who is at least 18 years old;
Patients who have maxillary anterior canines with a color equal to or darker than 2.5 M2 (on the Vita Bleachguide scale);
Agree to participate and sign the informed consent form."	"Presence of restorations in the upper anterior teeth.
Presence of visible cracks in the upper and lower anterior teeth.
Presenting any pre-existing general and/or oral medical condition that puts the individual at risk during the study.
Being pregnant or lactating.
Dental treatment planned to be performed during the course of the study.
Generalized periodontal disease.
Complex intrinsic staining due to tetracycline, fluorosis or hypocalcification.
Presence of tooth sensitivity, patients who have already undergone bleaching procedures; patients who have a bruxism habit or any other pathology that can cause sensitivity (recession, dentin exposure).
Teeth with active or chronic caries lesions in the elements."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-3wr768f	Randomized controlled clinical trial on the effects of mat pilates in community elderly	Recruitment completed	Intervention	2023-09-19	<NULL>	<NULL>	6452	Randomized controlled clinical trial on the effects of mat pilates on quality of life, functional capacity, physical fitness and risk of falls in community elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-06	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-3wr768f	<NULL>	Age between 60 and 75 years old; Be able to communicate, walk and lie down on the ground safely, even with assistance; Availability to participate in activities proposed by the researcher at the times offered for practice.	Those with central or peripheral neurological diseases will be excluded; Musculoskeletal or cardiovascular disorders contraindicated to the practice; Surgical procedures in the last six months contraindicated to the practice; Hypertension without drug control; Extreme obesity; Absence of medical release for the practice of physical activity; Not being vaccinated against Covid-19 and H1N1; Present conditions that compromise the physical assessments or that may be aggravated by the intervention protocol; History of myocardial infarction in the last 6 months; Have a cardiac pacemaker; Having total or partial arthroplasty (since it interferes with positioning oneself on the ground); Having osteosynthesis (in cases of risk of new trauma); If there is an obligation to use a face mask for individual protection during the intervention period, refuse to use it; Having suffered a fracture or muscle injury in the last 6 months that has not been rehabilitated;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-4k2s5d9	The Use and Acceptance of a Food Introduction Guide in the city of Campo Grande/MS	Recruitment completed	Intervention	2023-09-18	<NULL>	<NULL>	6444	Organizational Readiness for the implementation of a Food Introduction Guide in the city of Campo Grande/MS	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Instituto Integrado de Saúde da Universidade Federal do Mato Grosso do Sul	Instituto Integrado de Saúde da Universidade Federal do Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4k2s5d9	<NULL>	Professionals from the medical nursing and dental categories. working at one Basic Health Unit. both gender. regardless years of graduation	Professionals who are on leave. under 18 years of age. personal refusal	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-2v4qz72	Study of the effects of biperiden in the treatment of alcoholism	Not yet recruiting	Intervention	2023-09-18	<NULL>	<NULL>	6445	Effects of biperiden in the treatment of alcohol use disorder: a randomized, double-blind, placebo-controlled trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2023-09-28	Escola Paulista de Medicina - Universidade Federal de São Paulo	Escola Paulista de Medicina - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2v4qz72	<NULL>	Patients with alcohol dependence, according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition; age between 18 and 50 years old; male; literate the ability to write and read in Portuguese	Present other serious psychiatric disorders, such as schizophrenia and bipolar mood disorder; present severe dependence criteria for other drugs, except tobacco; have severe cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-8nwxhs4	Test validation for HRD detection using NGS methodology	Not yet recruiting	Observational	2023-09-18	<NULL>	<NULL>	6446	Homologous recombination deficiency (HRD) test validation by NGS methodology at Oncoclínicas Precision Medicine laboratory in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Oncoclinicas do Brasil Serviços Médicos S.A	LOCUS - Anatomia Patologia e Citologia LTDA	https://ensaiosclinicos.gov.br/rg/RBR-8nwxhs4	<NULL>	Patients &gt; 18 years old; diagnosed with high grade serous ovarian cancer; platinum-sensitive; mutant or wild type for germline or somatic HRR genes based on OCPM Next Generation Sequencing (NGS) panels.	Patient that do not accept to sign the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-2fs9kms	Development of a mobile application and the effectiveness of a brief asynchronous mindfulness and self-compassion intervention for cases of Anxiety, Stress and Depression	Not yet recruiting	Intervention	2023-09-18	<NULL>	<NULL>	6447	Development of a mobile application and the effectiveness of a brief asynchronous mindfulness and self-compassion intervention for cases of Anxiety, Stress and Depression in university students and teachers of basic education: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2024-03-01	Centro de Ciências Humanas, Letras e Artes - Universidade Federal da Paraíba	Centro de Ciências Humanas, Letras e Artes - Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2fs9kms	<NULL>	Study 1: be between the ages of 18 and 65; both genders; be Brazilian; being a basic education teacher; have internet access and a cell phone with Android system; be willing to download and use the application; achieving a score greater than 0 on symptoms of depression, anxiety, and stress measured by subscales of the Depression, Anxiety, and Stress Scale (DASS-21) (Vignola &amp; Tucci, 2014). Study 2: be between the ages of 18 and 35; both genders; be Brazilian; be a university student (undergraduate or graduate); have internet access and a cell phone with Android system; be willing to download and use the application; achieving a score greater than 0 on symptoms of depression, anxiety, and stress measured by subscales of the Depression, Anxiety, and Stress Scale (DASS-21) (Vignola &amp; Tucci, 2014)	Studies 1 and 2: already adopting a frequent mindfulness practice in the last 6 months; be using some type of psychotropic medication; being under psychological treatment; have a diagnosis of psychiatric or neurological illness (eg, schizophrenia, borderline personality disorder); not have or be willing to create a Gmail account	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-273z6gj	Pain sensation, hypervigilance and oral habits in individuals with Painful Temporomandibular Disorders and Tinnitus	Not yet recruiting	Observational	2023-09-17	<NULL>	<NULL>	6439	Pain Threshold, hypervigilance and oral behaviors in individuals with Painful Temporomandibular Disorder and Somatosensory Tinnitus	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-273z6gj	<NULL>	Volunteer individuals; both sexes; between 18 and 60 years old; diagnosed with painful temporomandibular disorder, defined by the Diagnostic Criteria for Temporomandibular Disorders and somatosensory tinnitus	Participants who do not agree to participate in the study; who have some cognitive difficulty that prevents them from answering the questionnaires; under 18 years old; with degenerative neurological diseases; history of psychiatric hospitalization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-3hv3hhs	Training on postpartum depression for nurses working in health centers	Not yet recruiting	Intervention	2023-09-17	<NULL>	<NULL>	6440	Continuing Education on Postpartum Depression for primary health care nurses: a quasi-experimental study	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-10	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-3hv3hhs	<NULL>	The study will be carried out with 96 participants; aged over 18; nurses who work in the Primary Health Care network and provide care to puerperal women	Nurses who do not provide nursing care to the puerperal woman; those who are on vacation or away from their work activities during the data collection period; or for some other reason that makes it impossible for them to participate; and those who fail to participate in any of the permanent health education meetings	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-5x49hb2	Treatment of Mandibular Advanced with a Propulsor appliance in young adults	Recruitment completed	Intervention	2023-09-17	<NULL>	<NULL>	6441	Treatment of Class II with Mandibular Propulsor and Skeletal Anchorage in young adults	<NULL>	array, randomized-controlled, open	<NULL>	<NULL>	<NULL>	<NULL>	2019-01-01	Faculdade de Odontologia Universidade de São Paulo	Faculdade de Odontologia Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5x49hb2	<NULL>	Brazilian nationality; convex facial profile; presence of overjet; Angle Class II; indication of mandibular advancement; no indication of premolar extractions; presence of all permanent teeth except third molars; no indication of mandibular advancement through surgical procedure.	Temporomandibular joint signs and symptoms; Poor dental and periodontal conditions; Previous orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-8m3htgm	Evaluation of the Activity of Supraphysiological Testosterone Doses in the Fall of PSA in Patients with Prostate Cancer Unresponsive to the lack of Testosterone and without Metastases	Not yet recruiting	Intervention	2023-09-17	<NULL>	<NULL>	6442	Evaluation of supraphysiological doses of Testosterone in patients with castration-resistant prostate Adenocarcinoma without metastases	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-28	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-8m3htgm	<NULL>	Patients between 18 and 75 years old; diagnosis of prostate adenocarcinoma without neuroendocrine differentiation or unconventional subtypes; resistant to surgical or medical castration; not metastatic; PSA doubling time &lt; 10 months	Patients with PS &gt; 2; Presence of moderate to severe organic dysfunctions related, among others, to liver, kidney or heart function; Uncontrolled primary prostatic disease; Presence of previous or current diagnosis of another neoplasm except non-melanoma skin cancer; Positive pelvic node disease, considered as any pelvic lymph node larger than 2.0 cm in the shortest axis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-6wbq6kw	Nursing telecare for people with spinal cord injury	Recruitment completed	Intervention	2023-09-15	<NULL>	<NULL>	6435	Telerehabilitation for people with spinal cord injury	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Associação das Pioneiras Sociais	Associação das Pioneiras Sociais	https://ensaiosclinicos.gov.br/rg/RBR-6wbq6kw	<NULL>	Adults diagnosed with spinal cord injury; paraplegics and quadriplegics; admitted to the ward of the Spinal Cord Injury Neurorehabilitation Program for rehabilitation program; age greater than or equal to 18 years	Patients who have already participated in the rehabilitation program at another time; patients with clinical complications that contraindicate rehabilitation and patients under 18 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-48hdw55	Effects of using pneumatic compression boot on muscle recovery after running downhill	Recruitment completed	Intervention	2023-09-15	<NULL>	<NULL>	6436	Effects caused by the use of pneumatic compression boots on performance indicators muscle recovery after running downhill: Randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-48hdw55	<NULL>	People from 18 years to 30 years old; men; physically active; without comorbidities; available to participate in all stages of the research.	Individuals who have a history of musculoskeletal injuries in the lower limbs or who make; impossible to carry out the actions proposed in the study; who have cardiovascular diseases and hypertension; who have not used caffeine 2 hours before the evaluation will not participate in the study; who will not sign the consent form of the search.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-9hvrmz8	Immediate placement delayed loading of a patient specific dental Implant; an essential experimental device exemption study	Not yet recruiting	Intervention	2023-09-15	<NULL>	<NULL>	6437	Immediate placement delayed loading of a patient specific one piece cad/cam designed dental implant: a pivotal ide study	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-11-01	Universidade de São Paulo - Faculdade de Odontologia	Atlantis Clinical Brazil LTDA	https://ensaiosclinicos.gov.br/rg/RBR-9hvrmz8	<NULL>	Subjects 22 to 75 years of age. Both sexes. Subject indicated for single-rooted tooth or fused premolar roots atraumatic extraction with the intention for immediate implant placement that does not require bone augmentation (i.e., no lateral, vertical, or sinus augmentation required), the implant restoration will support a single-unit prosthetic restoration. Proposed implant sites should have intact cortical plates (at least 1 mm in thickness) and free of apical lesions or marginal bone loss. Implant sites with sufficient soft tissue quality, quantity, and morphology that do not require augmentation (thick phenotype). Subjects will have read, understood, and signed an institutional review board approved Informed Consent Form. Subjects must be able and willing to follow study procedures and instructions	Subjects with a history of tobacco use within the last two years. Subjects with healing disorders (such as: diabetes mellitus confirmed HgA1C of &gt; 7 within six months prior to screening, cancer, HIV, bone metabolic diseases or Type IV heart disease) that could compromise wound healing and/or preclude implant surgery; or who are currently receiving, or have received within two months prior to study entry, systemic corticosteroids, immunosuppressive agents, radiation therapy, and/or chemotherapy which could compromise wound healing and/or preclude oral surgery. Subjects taking any bisphosphonates; Subjects taking hormone therapy or have had a hysterectomy. Female subjects who are pregnant or lactating, or who intend to become pregnant during the study duration. Subjects participating in other clinical studies involving therapeutic intervention (either medical or dental). Subjects with proposed implant sites that demonstrate soft tissue recession or soft tissue deficiency that requires soft tissue augmentation. Subjects with untreated periodontal disease or other uncontrolled infections of the oral cavity. Subjects who have a bruxing or clenching habit. Subjects with insufficient oral hygiene (plaque score &gt; 25%, bleeding on probing &gt; 50% of sites). Subjects, who in the opinion of the investigator, for any reason other than those listed above, will not be able to complete the study per protocol. Subjects with cuspid protected occlusion, where full disclusion of all working side posterior teeth occurs in lateral movements. Subjects with other implant treatments currently in progress or who require replacement of additional teeth within the time frame of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-10wr9c7d	Interventions to support the Recovery after Muscle Exhaustion	Not yet recruiting	Intervention	2023-09-15	<NULL>	<NULL>	6438	Interventions for Physical Recovery after Muscle Fatigue	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-25	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-10wr9c7d	<NULL>	College athletes of any sport; of both genders; over 18 years old; to train at least three times a week at a competitive level	Interruption of sports activities in the last six months due to injuries; report of any neurological, musculoskeletal, cardiovascular, pulmonary or metabolic condition that may interfere or contraindicate the research procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-4s4kt2r	Non-Invasive Stimulation in individuals with Chronic Stress	Data analysis completed	Intervention	2023-09-14	<NULL>	<NULL>	6430	Effects of Transcranial Direct Current Electrical Stimulation on right and left dorsolateral prefrontal cortex or Noninvasive Vagus Nerve Stimulation in Chronically Stressed adults	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4s4kt2r	<NULL>	Individuals diagnosed with stress; Lipp Adult Stress Symptom Inventory (ISSL) score greater than 4; cognitive ability to read and interpret the purpose of the research and answer the assessment instruments; and acknowledgment and approval of the informed consent form; male or female volunteers aged between 20 and 50 years	Smokers; with a history of dizziness or seizure; pregnancy; signs of severity and/or indications for hospitalization or psychotherapy; use of anxiolytics; use of antidepressants; adverse effects detected in the group treated with tDCS and taVNS, including itching, tingling, headache, burning sensation and discomfort; diagnosis of depression; anxiety diagnosis; mood disorder bipolar with depressive, manic or hypomanic symptoms in the last year; schizophrenia or other psychotic disorders; autism; dependency of substances; diagnosis of epilepsy or use of anticonvulsants; contraindications for TDCS (metallic implants, tumor, brain surgeries previous, important cranioencephalic anatomical alteration); contraindications for non-invasive vagus nerve stimulation (cochlear implant, ear plastic surgery, ear malformation); starting and/or changing the dose of psychopharmaceuticals in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-10r8cr8y	Relationship between baseline dental pulp response to stimulations and skin pressure sensitivity	Data analysis completed	Observational	2023-09-14	<NULL>	<NULL>	6432	Relationship between baseline pulpal response to electrical stimulation and skin pressure sensitivity	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-09-12	Faculdade de Odontologia da Universidade Estadual de Campinas	Faculdade de Odontologia da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10r8cr8y	<NULL>	aged between 18 and 35 years, classified as healthy through anamnesis, caries-free central incisors and upper canines and extensive restorations, trauma or endodontic treatment and responsive to electrical stimulation (pulp tester)	pregnant women, smokers, people undergoing tooth whitening in the past three months, evidence of organic dysfunction or clinically significant deviation from normal, history of psychiatric illness that could compromise the ability to provide written consent, history of drug addiction or drug abuse alcohol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-4prstkz	Effect of the intervention on diet and exercise in the treatment of gingival disease in adult patients who attend the USFQ dental clinic for treatment. Quito – Ecuador 2022 – 2024.	Recruiting	Intervention	2023-09-14	<NULL>	<NULL>	6433	Effect of the intervention on common risk factors in the treatment of Periodontitis in adult patients who attend the USFQ dental clinic for treatment. Quito – Ecuador 2022 – 2024.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidad San Francisco de Quito	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-4prstkz	<NULL>	Age equal to or greater than 30 years; of both sexes; with more than 15 teeth, at least 30% of which have probing depth (PD) and attachment loss (AL) of at least 4mm and bleeding on probing (SS) or with 6 or more teeth with at least 1 site with PD and AL≥5mm; BMI less than 30.	Pregnant or breastfeeding women; Smokers; Patients with other systemic diseases; Scaling and Root Planing performed in the last 12 months; Patients on antibiotic therapy in the last 6 months; Patients on prolonged use of anti-inflammatory drugs; Patients who need antibiotic premedication for dental treatment; Patients who practice regular physical exercise or have been on a diet in the last 6 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-8bbz36g	Supervised versus Minimally Supervised Exercises in the Treatment of Chronic Neck Pain	Not yet recruiting	Intervention	2023-09-14	<NULL>	<NULL>	6434	Supervised versus Minimally Supervised Exercises in the Treatment of Non-Specific Chronic Neck Pain: Randomized and Blinded Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-10	Departamento de Fisioterapia da UFRN	Departamento de Fisioterapia da UFRN	https://ensaiosclinicos.gov.br/rg/RBR-8bbz36g	<NULL>	Individuals of both sexes; age between 18-50 years; present a primary complaint of non-specific neck pain (equivalent to classification grades I and II according to the Neck Pain Task Force)(5), present pain for 12 weeks or more; presenting pain equal to or greater than 3 on the END (numerical pain scale 0-10); understand, tolerate and monitor assessment and intervention procedures; not having performed previous surgery of the cervical spine.	Subjects who have blood clotting disorders, diffuse idiopathic skeletal hyperostosis (DISH), significant infectious disease, or other serious disabling health conditions; Pregnant or breastfeeding women; or having received treatment in the past 2 months for neck pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-10jpb6v7	BRALLA protocol	Recruiting	Observational	2023-09-13	<NULL>	<NULL>	6429	Adult Acute Lymphoblastic Leukemia treated with pediatric regimen – a prospective observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-07-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Servier Affaires Médicales	https://ensaiosclinicos.gov.br/rg/RBR-10jpb6v7	<NULL>	Patients between 16 and 50 years-old; both genders; with newly diagnosed Acute Lymphoblastic Leukemia - ALL; negative for Philadelphia chromosome; not previously treated (except for hydroxyurea, corticosteroids, or intrathecal chemotherapy) with at least 20% blasts in peripheral blood and/or bone marrow	Burkitt leukemia. Prior chronic myeloproliferative disease. Philadelphia chromosome positivity. ECOG&gt;2. Total bilirubin&gt;2x upper limit of normality. Transaminases&gt;5x ULN. Creatinine&gt;2,5 mg/dl. Positive serology for HIV or HTLV. Heart failure NYHA Class III or IV. Severe psychiatric disorder which prevents adequate compliance. Prior treatment with intravenous chemotherapy, except for hydroxyurea and corticosteroids. Refusal to participate in the study. Down syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-5cbvq6p	Evaluation of the Allergy potential of a Cosmetic Product (HRIPT+Phototest)	Not yet recruiting	Intervention	2023-09-12	<NULL>	<NULL>	6424	EN22-0674-01_02_Allergenic evaluation for Cosmetic Product (HRIPT+Phototest)	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-13	Medcin Instituto da Pele Ltda	Megalabs Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-5cbvq6p	<NULL>	Participants of both sexes aged 18 to 70 years; intact skin in the region of application; agreement to follow trial procedures and to report to the clinic on designated days and times for medical assessments and application and reading of pads; understanding, consent and signature of the Free and Informed Consent Term (TCLE); phototype: I, II, III and IV (for the phototest test, only phototypes II and III will be considered)	For the HRIPT trial and phototest: Participants who have been diagnosed with COVID 19 within the last 4 weeks or who are experiencing symptoms such as fever, dry cough, tiredness, body aches or other discomforts; pregnancy or risk of pregnancy and/or lactation (when women); use of anti-inflammatory drugs 30 days and/or immunosuppressants for up to three months before selection; immunosuppression by drugs or active diseases; decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the evaluation or during the study period; anticipated intense exposure to sunlight or tanning sessions during the study period; prediction of sea bathing, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; aesthetic and/or dermatological treatment on the body within 03 weeks before selection; scheduled vaccination during the study period or up to 03 weeks before selection; history of sensitization, irritation, or photosensitivity to topical products; active skin pathologies (local and/or disseminated) that may interfere with the study results; skin reactivity; use of new drugs/cosmetics during the study; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; history of known or suspected intolerance to any ingredient of the study products (test or comparative product); history of non-compliance or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participation in the study. If yes, it should be described in observation in the clinical record. Only for the phototest test: previous history of pathologies aggravated or triggered by ultraviolet radiation; use of photosensitizing drugs; history or activity of photodermatoses; personal or family history of skin cancer; presence of precursor lesions of skin cancer, such as melanocytic nevi and actinic keratoses; use of new drugs/cosmetics during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-256qw7j	Comparison of the clinical performance of dental restorations using regular or flowable resins	Recruiting	Intervention	2023-09-12	<NULL>	<NULL>	6425	Comparison of the clinical performance of restorations in posterior teeth using conventional or flowable resin composite	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	Instituto de Ciência e Tecnologia de São José dos Campos - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-256qw7j	<NULL>	Two posterior teeth needing restorations in the same patient (class II); large cavities or deficient restorations with similar dimensions, cavities involving the same number of tooth surfaces; presence of antagonists and opposing teeth making contact, vital pulp; good oral health; aged between 18 and 70 years and both genders	Very deep carious lesions; crowns that are impossible to restore directly; accidental pulp exposure during caries removal; teeth previously submitted to direct pulp capping; teeth with spontaneous or constant pain, indicative of irreversible pulpitis; severe systemic disease; allergy to restorative materials; periodontal disease; bruxism; deleterious parafunctional habits; history of hypersensitivity in the teeth to be restored	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-9m943sp	Comparative study between two modalities of Diode Laser Surgery in patients with Refractory Glaucoma	Recruiting	Intervention	2023-09-12	<NULL>	<NULL>	6427	A randomized clinical trial of slow coagulation (SC-CPC) vs subliminal subthreshold (SS-CPC) transscleral diode laser cyclophotocoagulation procedure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9m943sp	<NULL>	Patients between 18 and 80 years of age; Both genders; Uncontrolled intraocular pressure despite maximal topical therapy; Impossibility of performing trabeculectomy; Absence of previous cyclodestructive procedure	Single eyed patients; Albino phenotype; Previous ocular history of uveitis, surgery or corneal disease that precludes an intraocular pressure measurement; Presence of significant scleral thinning; Any medical conditions that prevent these individuals from providing reliable and valid data for the study; Patients enrolled in other prospective clinical trials	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-3m97hhq	Evaluation of an education method on the severity of the Atopic Dermatitis disease and on the quality of life of children and their guardians	Recruitment completed	Intervention	2023-09-11	<NULL>	<NULL>	6419	Evaluation of an educational intervention on the severity of the disease Atopic Dermatitis and the quality of life of children and their caregivers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3m97hhq	<NULL>	Children under the age of 15 and their respective primary caregiver who attend the consultation at the Pediatric Dermatology service of the Hospital de Clínicas Complex; children who meet the Hanifin and Rajka criteria for the clinical diagnosis of atopic dermatitis; children who do not have other chronic diseases, with the exception of mild asthma and rhinitis; children accompanied by their primary caregivers; literate caregivers who answer the Quality of Life questionnaires; guardians who have a cell phone that supports the Whatsapp® application and have enabled the read confirmation option and who have an active phone line and mobile Internet or WiFi available; who agree to participate and sign the Informed Consent Form and Informed Consent Form, when applicable	They started using immunosuppressants during the evaluation period or up to 2 months before inclusion in the study; who do not return for revaluations in the specified period; withdraw the Free and Informed Consent form and the Free and Informed Consent Term	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-6bc6xcx	The influence of the simulated environment, with and without the examiner on students&apos; abilities to assess shockable cardiac arrhythmias	Recruitment completed	Intervention	2023-09-11	<NULL>	<NULL>	6420	The influence of the simulated environment, with and without the examiner, on the skills and confidence of students in the assessment of shockable cardiac arrhythmias: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6bc6xcx	<NULL>	Students regularly enrolled in the eighth period of the course in Nursing in Adult and Elderly Health II; with a minimum age of 18 years; both genders	Students who were not attending the course, due to withdrawal from enrollment or leave of any nature; students who dropped out or who did not take the immediate post-test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-5k87yqm	Laser Therapy combined with Vacuum in the plantar region in patients with Type 2 Diabetic Neuropathy	Terminated	Intervention	2023-09-11	<NULL>	<NULL>	6422	Acute effect of the use of Vacum Laser Therapy in the plantar region on muscle electrical activity and balance in patients with Type 2 Diabetic Neuropathy: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5k87yqm	<NULL>	Age between 50 and 70 years old; 10 years or more of onset of diabetes; BMI less than 25 kg/m2; present a score above 3 on the scale of neuropathic impairments and symptoms	Individuals who use muscle relaxants; use of any walking device; Lower extremity orthopedic and dermatological problems; body mass index above 25Kg/m2; upper motor neuron lesion; foot ulcers; deep vein thrombosis; phlebitis; having a score of less than 3 on the scale of neuropathic impairments and symptoms	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-5tbt8k2	To explore if changes in socio-emotional aspects, induced by Classes for Knowledge about Pain, can modify the performance of functional tasks in the context of Chronic Low Back Pain: a randomized clinical trial	Recruiting	Intervention	2023-09-11	<NULL>	<NULL>	6423	To explore if changes in psychosocial outcomes, induced by Pain Neuroscience Education, can transfer to functional outcomes in the context of Chronic Low Back pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5tbt8k2	<NULL>	Physically inactive volunteers; aged between 18 and 59 years; both genders; with report of persistent or intercurrent low back pain for more than three months; low back pain, with physical characteristics compatible with mechanical etiology according to the evaluation and treatment guidelines proposed by the American College of Physicians and by the American Pain Society	History of spinal surgery; pregnancy; absence of safe hemodynamic conditions to perform walking or clinical tests; significant increase in pain during the tests, making walking an intolerant activity by the perception of the volunteer; worsening of the chronic condition on the day of the test, identified by pain intensity measured by the visual analog scale (VAS), at rest, greater than eight; symptoms of acute diseases, such as colds and flu; body mass index (BMI) greater than 30	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-5pp4nks	Evaluation of the use of Probiotics for infant colic	Recruiting	Intervention	2023-09-09	<NULL>	<NULL>	6415	Effect of using Probiotics (Lactobacillus acidophilus) on colic in infants: a double-blind randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Goiás	Cifarma ltda	https://ensaiosclinicos.gov.br/rg/RBR-5pp4nks	<NULL>	Infants with mothers aged 18 or over will be selected; infants aged between 2 and 12 completed weeks of life; born at term, with a birth weight of 2500 g or more; who present uncontrollable crying for at least 3 hours a day and 3 days a week for at least one week (according to the criteria of ROME IV)	Infants who were exposed to the use of probiotics before or during the study will be excluded; and/or who have gastroesophageal reflux disease using specific medication (proton pump and/or prokinetic inhibitors); and/or who have gastrointestinal tract malformations; and/or who need to use antibiotics during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-6xw6y4w	Impact of the drug Mannitol on brain pressure during Video Prostate Removal Surgery	Recruiting	Intervention	2023-09-09	<NULL>	<NULL>	6416	Impact of Mannitol on intracranial pressure, assessed using optic nerve sheath ultrasonography, during Videolaparoscopic Prostatectomy	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-05-23	Hospital Universitário Onofre Lopes	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-6xw6y4w	<NULL>	Male gender; diagnosis of prostate cancer; age between 20 and 79 years	Patients with pathologies that increase intracranial pressure; previous neurosurgery; glaucoma; ophthalmological surgery; heart, liver or kidney failure; American Society of Anesthesiology classification more than III; patients who have surgery converted to open modality or who present hemodynamic instability during the transoperative period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-8t6qj75	Effect of Hyaluronic Acid Injection in the subtalar joint of patients with Osteoarthritis	Recruitment completed	Intervention	2023-09-09	<NULL>	<NULL>	6417	Functional evaluation of the results of the Hyaluronic Acid Injection in the subtalar joint in patients with post-traumatic Osteoarthritis who underwent Osteosynthesis of the calcaneus with a Kirschner wire	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-18	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	https://ensaiosclinicos.gov.br/rg/RBR-8t6qj75	<NULL>	Patients of both genders; who underwent intra-articular infiltration for the treatment of symptomatic subtalar osteoarthritis secondary to calcaneal fracture at the National Traumatology and Orthopedics Institute between 2017 and 2018 (at the time of the trauma, all patients were treated with osteosynthesis of the calcaneus with a Kirschner wire, a standard treatment at the foot service and ankle of the Institution); and who were selected to participate in a study to evaluate the outcomes of subtalar osteoarthritis after intra-articular injections	Patients with subtalar ankylosis; previous infection; radiographic parameters compatible with inadequate joint reduction; hypersensitivity to hyaluronic acid; pregnancy and breastfeeding; concomitant diseases affecting the joint; open wound or ulcer; use of anticoagulants or altered bleeding time; intra-articular injection or arthroscopy less than 6 months; and patients undergoing subtalar arthrodesis and, therefore, they did not participate in the initial study with a follow-up of 6 months after intra-articular injections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-10ch2tf2	The effect of using two mouthwashes in the treatment of mucosal inflammation around dental implants	Recruitment completed	Intervention	2023-09-08	<NULL>	<NULL>	6412	Clinical evaluation of the efficacy of two types of oral antiseptics in the treatment of Mucositis and Peri-Implantitis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-02	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10ch2tf2	<NULL>	Presence of at least 1 titanium dental implant with mucositis or peri-implantitis; presence of sub and supra gingival plaque; signs of inflammation; no maintenance therapy in the last three months; progressive marginal bone loss (MBL) of 3 mm at least one point.Increased probing depth (PD) (6 mm) at least one point; total or partially edentulous patients; residents of the Greater Florianópolis region e greater Florianópolis region.	Carriers of autoimmune diseases; taking anti-inflammatory drugs, antibiotic therapy, or have taken in the last three months; smokers or users of alcohol users; carriers of diabetes mellitus; carriers of neoplasms; carriers of obstructive pulmonary diseases; carriers of renal diseases; renal diseases; patients with familial hypercholesterolemia; patients with other systemic diseases compromise their health of the patient.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-8cn9qqg	Effect of passion fruit species on human health and the bioavailability of its bioactive compounds	Recruitment completed	Intervention	2023-09-08	<NULL>	<NULL>	6413	Passiflora: interindividual variation in the bioavailability of phenolic compounds and effect on metabolic response	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-29	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8cn9qqg	<NULL>	Nutritional diagnosis of overweight and obesity grade 1 (Body Mass Index - BMI= 25-31 Kg/m2 and 25 to 29.9 Kg/m2); with cholesterol levels above 190 mg/dl; aged between 30 and 55 years; both genders	Previous history of cancer or severe metabolic diseases; digestive system disorders; smoking; allergy to passion fruit and fruit-based products; use of supplementation in the two months prior to the experiment (vitamin C, multivitamin, antioxidant capsules , etc.) or drugs for chronic treatments (antihypertensives, antihyperglycemics, anticholesterol, antidepressants, sleep aids, tranquilizers, etc.); acute treatments in the 15 days prior to the experiment (anti-inflammatories, antibiotics, etc. ); acute treatments in the two days prior to the experiment (inflammatory analgesics such as aspirin, acetaminophen, etc.)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-4pzsfxw	Effects of adding Gait Retraining to lower limb muscle Strengthening on clinical, functional and kinematic parameters of individuals with knee Arthrosis	Not yet recruiting	Intervention	2023-09-08	<NULL>	<NULL>	6534	Effects of adding Gait Retraining to Lower Limb Muscle Strengthening on clinical, functional and kinematic parameters of individuals with knee Osteoarthritis: a double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-18	Universidade Federal de Juiz de Fora	Programa de Pós-Graduação em Ciências da Reabilitação e Desempenho Físico-Funcional da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4pzsfxw	<NULL>	Reliability test participants: students from the Federal University of Juiz de Fora; age equal to or greater than 18 years; no inflammatory, autoimmune, infectious, or traumatic arthropathies; no history of surgery of any joint of the lower limbs; did not use intra-articular injections in the last 6 months. Participants in the intervention or control groups: individuals aged 50 to 65 years; clinical diagnosis of unilateral and bilateral knee osteoarthritis according to the criteria of the American College of Rheumatology; radiographic severity grade II and III according to Kellgren and Lawrence criteria; able to walk freely for at least 10 minutes without needing an assistive device; no inflammatory, autoimmune, infectious, or traumatic arthropathies; no history of arthroplasty or any other surgery of any joint of the lower limbs; who did not use intra-articular injections in the last 6 months; body mass index less than 30 kg/m2; lack of diagnosis of neurological diseases, whether central or peripheral, and vascular diseases of the lower limbs; controlled blood pressure levels, with resting systemic blood pressure below 160/110 mmHg	Participants who do not have the minimum score on the Mini Mental State Examination test; participants who perform intra-articular or surgical infiltration procedures during the application of the research protocol; those who present cardiovascular decompensations, given by pressure levels higher than 220/105 mmHg during the execution of the exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-8dwf73m	Prevention of Eating Disorders	Not yet recruiting	Intervention	2023-09-06	<NULL>	<NULL>	6410	Prevention of Eating Disorders	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade de Franca	Universidade de Franca	https://ensaiosclinicos.gov.br/rg/RBR-8dwf73m	<NULL>	Female adolescents from public schools in a city in the interior of São Paulo who voluntarily agreed to participate in the study; aged between 11 and 14 years; who are not pregnant; who did not have a diagnosis of psychiatric illness - except for eating disorders; who are unable to hear or communicate.	The exclusion criteria adopted for the groups will be: adolescents in a situation of pregnancy; who did not present the minimum conditions necessary to perform the task in a group, both in cognitive terms (indication of lowering in the intellectual level, evaluated empirically), and clinically (presence of severe organic or psychiatric disease - in the latter case, except for the diagnosis of AN in the RG), or even hearing or communication impairment that made it impossible to carry out the group interview	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-8tvzdr7	Evaluation of the effectiveness of the simulated environment in training nursing students in cardiac arrest care	Recruitment completed	Intervention	2023-09-06	<NULL>	<NULL>	6411	Evaluation of the effectiveness of a simulated environment on the safety, skills and knowledge of nursing students in cardiac arrest care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8tvzdr7	<NULL>	Students regularly enrolled in the eighth period of the course in the subject Nursing in Adult and Elderly Health II	Students who were not attending the course, due to withdrawal from enrollment or removal of any nature; Students who dropped out or who did not take the immediate post-test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-76jstwc	Functional Training in Pain reduction and improvement of Core Function in healthy young women	Recruitment completed	Intervention	2023-09-05	<NULL>	<NULL>	6406	Effects of Functional Training on Endogenous Pain Modulation and Core Function in healthy young women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-76jstwc	<NULL>	Women between 18 and 48 years old	Pain in the last three months; Inactive; have used analgesic, anti-inflammatory, opioid or immunosuppressive medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-25zhwfj	Early Palliative Care for patients with Hematological Neoplasms	Recruiting	Intervention	2023-09-05	<NULL>	<NULL>	6407	Prognostic and Epidemiological Evaluation of Palliative Care in Hematological Diseases	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-16	Hemocentro de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-25zhwfj	<NULL>	Multiple myeloma, newly diagnosed; previously untreated. Acute myeloid leukemia, newly diagnosed; ineligible to intensive chemotherapy; 60 years-old or higher	Cognitive impairment compromising responses to clinical questionaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-6t6grh7	Effect of an ankle-focused Global Exercise program on static posture balance, task stability, and functionality in individuals with Ankle Instability	Not yet recruiting	Intervention	2023-09-05	<NULL>	<NULL>	6408	Effect of a Global Rehabilitation program with local emphasis on static postural control, stability, dynamics and functionality in individuals with lateral ankle Instability - Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-30	Escola de educação física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Escola de educação física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6t6grh7	<NULL>	The sample of this study will be for convenience and will consist of individuals of both sexes; aged between 18-45 years; body mass index less than 30 kg/m²; with no history of other injuries in the lower limbs; without acute ankle sprains ( minimum three months prior to the collection); who do not participate in other rehabilitation programs; and who report the presence of the following criteria: having a history of at least one ankle sprain associated with pain requiring a change in gait pattern; avoiding weight bearing on the foot affected for at least one day; present a feeling of weakness, pain or instability that appeared after the traumatic ankle event; present a score less than or equal to 24 on the Cumberland Ankle Instability Tool	Individuals who are unable to attend the reassessments (cannot be contacted or have an injury that prevents the proposed tests from being carried out) and who initiate some other type of treatment after the start of the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-2bxfbk8	Effect of Laser Therapy to Reduce Pain and Scarring in Postpartum Women	Recruiting	Intervention	2023-09-05	<NULL>	<NULL>	6806	Acute Effect of Low-Intensity Laser Therapy for Pain Reduction and Healing of Fissured Nipples in Postpartum Women: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-20	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2bxfbk8	<NULL>	Women; age from 18 years until 41 years; primiparous or multiparous; postpartum women up to 15 days postpartum; with some degree of nipple injury resulting from breastfeeding; babies born weighing at least 2500g; single pregnancy; in exclusive breastfeeding; no history of interventions with laser therapy in the previous 15 days; able to speak and understand the Portuguese language; who show interest in the project; be able to attend the Women&apos;s Health Research Laboratory (LAPESM); who can receive calls and messages via Whatsapp within 48 hours of the intervention; who sign the Free and Informed Consent Form (TCLE);	Women with inverted or pseudo-inverted nipples; who have mastitis during the intervention period; to start using antibiotic anti-inflammatory analgesics or any topical substance on the nipple (except breast milk); with photosensitivity or any adverse reaction to exposure to sunlight;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-8zvwkv8	Genial Care model: treatment for children with autism spectrum disorder	Not yet recruiting	Observational	2023-09-04	<NULL>	<NULL>	6404	Genial Care model: intervention for children with autism spectrum disorder	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-11-01	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo PUCSP campus Sorocaba	Faculdade de Ciências Médicas e da Saúde da Pontifícia Universidade Católica de São Paulo PUCSP campus Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-8zvwkv8	<NULL>	Children aged between zero and five years; children of both genders; children belonging to any social group, skin color, race, or ethnics; children diagnosed with autism spectrum disorder; children that are not being submitted to a similar intervention protocol; children whose guardian is available for conducting the child to the Genial Care clinic or partner clinic; children whose guardian is available for participating in parental guidance; children whose guardian has access to the Internet	Children that are being submitted to a similar intervention protocol; children aged over five years; children whose guardian is not available for conducting the child to the Genial Care clinic or partner clinic; children whose guardian is not available for participating in parental guidance; children whose guardian does not have access to the Internet	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-6f2fgkn	Comparison of the application of Current Therapy to the unilateral versus bilateral tibial nerve in women with Urine Leakage	Recruiting	Intervention	2023-09-04	<NULL>	<NULL>	6405	Comparison of unilateral versus bilateral tibial nerve Electrical Stimulation in women with Overactive Bladder Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Estadual de Campinas - UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-6f2fgkn	<NULL>	Women aged 18 or over; diagnosed with overactive bladder syndrome or mixed urinary incontinence with predominance of urgency; women who voluntarily accept the informed consent form (ICF); know how to read and write	Neurological problems or suggestive of neurogenic bladder; proven or suspected pregnancy; any previous treatment for overactive bladder syndrome in the last 3 months; women diagnosed with interstitial cystitis; use of medication to treat overactive bladder syndrome (antimuscarinic and beta-adrenergic) in the last 3 months; women with a history of cervical, endometrial or vulvar cancer; previous pelvic radiotherapy or brachytherapy; women with signs and symptoms of Urinary Tract Infection (UTI) or Pelvic Inflammatory Disease at the time of enrollment; women with genital prolapses assessed at the surgical gynecology outpatient clinic and with a Pelvic Organ Prolapse Quantification (POP-Q) classification greater than grade 2; cardiac pacemaker; previous surgeries to treat urinary incontinence; decompensated diabetes mellitus; loss of peripheral sensitivity on physical examination; skin lesions where the electrode will be placed; use of metallic implants in the region of the lumbar spine, foot and ankle; hormone replacement therapy (HT) in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-26b5dtq	Effect of a2 milk, biofortified or not, on the diet of children with Autism Spectrum Disorder	Recruitment completed	Intervention	2023-08-31	<NULL>	<NULL>	6401	Effect of milk biofortified with selenium and vitamin e from cows with genotype a2a2 in the diet of children with Autism Spectrum Disorder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-03	Faculdade de Zootecnia e Engenharia de Alimentos da Universidade de São Paulo	Fonterra Co-operative Group Ltd	https://ensaiosclinicos.gov.br/rg/RBR-26b5dtq	<NULL>	Child aged 3 to 10 years; male and female gender; diagnosis of Autism Spectrum Disorder (ASD) according to the evaluation criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); being classified into one of the three grades of autism	Positive diagnosis for cow’s milk protein allergy. Use of antibiotics or in the last 7 days prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-4jvyfh3	Auditory and visual therapy for children with comprehension difficulties	Recruiting	Intervention	2023-08-31	<NULL>	<NULL>	6402	Effect of auditory and visual Training in children with auditory processing Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4jvyfh3	<NULL>	Submit a signed term of consent and assent; Individuals aged 7 and 10, male and female; Audiometric thresholds within normal ranges at the time of assessment; Type A tympanometric curve and presence of ipsi and contralateral acoustic reflexes; Scale of Auditory Behaviors questionnaire with a score of less than 46 points, which indicates a risk situation for Auditory Processing Disorder; Diagnosis of Central Auditory Processing Disorder, carried out by the researchers, characterized by alteration in at least two of the behavioral assessment tests of Central Auditory Processing; Show alteration in the evaluation of Auditory Processing and visual perception; Not present neurological alterations, genetic syndromes or other pertinent conditions that could influence the evaluations; Present receptive and expressive language necessary to understand the commands necessary to perform the tests	Not being able to complete the battery of tests due to lack of understanding of them; Present neurological alterations, genetic syndromes or other pertinent conditions that may influence the evaluations; Not being available to attend intervention sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-595kgk7	Effects of Spirulina Platensis supplementation on inflammation and body composition in adults following surgical treatment for obesity	Recruitment completed	Intervention	2023-08-29	<NULL>	<NULL>	6398	Effects of Spirulina Platensis Supplementation on inflammatory markers, mitochondrial oxidative stress and body composition in adults after bariatric surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-05	Universidade Federal de Mato Grosso - UFMT	Centro Universitário de Várzea Grande - UNIVAG	https://ensaiosclinicos.gov.br/rg/RBR-595kgk7	<NULL>	adult individuals; of both sexes; aged between 18 and 59 years; with a Body Mass Index (BMI) greater than or equal to 40 or greater than or equal to 35 with morbidities associated with obesity such as type 2 diabetes mellitus, hypertension, dyslipidemia; who will undergo gastric bypass bariatric surgery treatment, and who will be regularly monitored by the research team	individuals who have a medical diagnosis of consumptive diseases such as stage 3, 4 or 5 chronic kidney disease; acute or chronic pancreatitis; severe acute infections; individuals who report the use of narcotic drugs and who are using vitamin or mineral supplements during the study period; or who have special physical conditions that interfere directly, causing errors in interpretation of the parameters investigated	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-96bkkj7	Effect of photon electromagnetic device in patients with neck pain	Recruitment completed	Intervention	2023-08-29	<NULL>	<NULL>	6399	Effect of Bioelectromagnetism and Photontherapy in patients with cervico- brachial neuralgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Fundação de Amparo à Pesquisa do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-96bkkj7	<NULL>	Adult individuals; age between 18 and 65 years; both genders; report neck pain equal to 4 or more on the VAS scale.	"Individuals with pain less than 4 on the VAS; pregnant women; cardiac pacemakers and other electronic implants; post-traumatic neck pain; patients with visual and hearing disorders; sleep, cognition and emotion disorders and individuals who used analgesics, muscle relaxants and anti-inflammatory drugs in the last 12 hours.
painkillers, muscle relaxants and anti-inflammatory drugs in the last 12 hours."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-10np4cyz	CO2 Laser to treat patients diagnosed with Hyperactive Bladder	Recruiting	Intervention	2023-08-29	<NULL>	<NULL>	6400	CO2 Laser treatment on Hyperactive Bladder	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Univesidade Federal de São Paulo	Univesidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10np4cyz	<NULL>	Women diagnosed clinically with Overactive Bladder Syndrome; Age between 18 and 80 years; Signature of the consent form; A 3-day voiding diary showing 8 or more voids in 24 hours and at least 1 episode of urinary urgency.	Untreated urinary infection; untreated genital infection; Bladder Pain Syndrome; Neurogenic bladder; Stroke, neurological or neurodegenerative diseases; Genital prolapse of any compartment above the hymenal ring; Urinary tract lithiasis or tumors; Physiotherapeutic or drug treatment for SBH within the past 2 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-3m5rqzh	Use of Repetitive Transcranial Magnetic Stimulation in the treatment of Dementia	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6391	Repetitive Transcranial Magnetic Stimulation in the adjunctive treatment of Neurodegenerative Disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-03	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3m5rqzh	<NULL>	Diagnosis of dementia,Complementary imaging exam for the diagnosis of dementia;either Alzheimer&apos;s Dementia, Mixed,Frontotemporal Lobar Degeneration,Lewy bodies, among others;use of acetylcholinesterase inhibitors and or memantine in doses stable for at least 3 months;clinical dementia rating ≤ 2;the patient must be able to communicate,read and understand the term informed consent and be able to carry out assessments neuropsychological	Comorbidity with previously diagnosed psychiatric illness,contraindications to performing the neuromodulation method non-invasive like epilepsy,metal brain implants, non-removable metallic implants, cardioverter defibrillators,implantable devices, trauma or brain tumor;decompensated clinical disease like neoplasms, heart disease, pulmonary, hepatic, renal,and endocrine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-96yz64d	Evaluation of the clinical efficacy of Red Propolis-Modified Dental Cements	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6392	Evaluation of the clinical efficacy of Red Propolis-Modified Restorative Glass Ionomer Cements: a prospective randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-96yz64d	<NULL>	Patients who have vital teeth in need of deep class II restorations, evaluated clinically and radiographically, will be included in the study. They must be over 18 years old, free of systemic diseases and parafunctional habits	Exclusion criteria are: teeth with irreversible pulpitis or with indication for endodontic treatment; presence of abscess in antagonistic or adjacent teeth; teeth with periodontal and/or periapical pathologies; patients with extremely poor oral hygiene, xerostomia or with a history of allergies to the materials used; patients undergoing orthodontic treatment; pregnant or lactating patients.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-8xh2j23	Association between delta anion gap/delta bicarbonate and patient outcome in surgical patients admitted to intensive care	Data analysis completed	Observational	2023-08-28	<NULL>	<NULL>	6393	Evaluation of the delta anion gap / delta bicarbonate correlation in the outcome in the ICU of patients undergoing major surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2012-09-03	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HC- FMUSP	Hospital do servidor Público Estadual de São Paulo - HSPE/IAMSPE	https://ensaiosclinicos.gov.br/rg/RBR-8xh2j23	<NULL>	Surgical patients (age ≥ 18 years) admitted to the ICU consecutively during the study period and at least one of the following criteria: severe cardiorespiratory disease (presence of coronary artery disease, aortic surgery, chronic obstructive pulmonary disease, or stroke); cancer surgery with extensive resection (esophagectomy, total gastrectomy, liver resection, pancreatectomy, cystectomy or total colectomy); surgical time greater than 6 hours; severe polytrauma; Massive intraoperative blood loss (hematocrit &lt; 20%); intraoperative circulatory shock (mean arterial pressure &lt; 60 mmHg) requiring vasopressors; previous nutritional disorder; body mass index &lt; 20; patients over 65 years of age with evidence of physiological limitation in at least one vital organ	"Patients who stayed less than 24 hours in the intensive therapy ; patients with low life expectancy (cancer with no prospect of treatment); patients with liver failure - (child B or C); patients with renal insufficiency (creatinine clearance &lt; 50mL/min or prior hemodialysis); diagnosis of previous diabetes or two blood glucose levels &gt; 126 mg/dL after
perioperative 8-hour fasting"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-835555x	Effects of the consumption of Coffee with Cocoa and Cinnamon in the cardiovascular health	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6394	Cardiovascular effects of consumption of Coffee formulations enriched with Cocoa and Cinnamon: ECARDIO-CACACA study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-10	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-835555x	<NULL>	Be aged between 18-80 years; Mini-Mental State Examination ≥ 27 points; ≥ 22 points (person with 1-11 years of education) and ≥ 9 points (illiterate person); female patient; have telephone contact; Not allergic to products derived from cocoa, coffee and/or cinnamon; Have been diagnosed with high blood pressure for at least six months; Living in the health territory.	Being a chronic user of glucocorticoid and/or psychotropic drugs; Being a user of ≥ 3 different pharmacological classes of antihypertensive drugs; Being afflicted with diabetes; Being pregnant or breastfeeding; Being a woman with a history of osteoporosis; Having been submitted to some surgical treatment less than 30 days ago; be a smoker; Have severe kidney, liver, or cardiovascular problems.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-6gpvcvr	Auriculotherapy in labor pain: randomized clinical trial	Recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6396	Effects of auriculotherapy in pain reduction in parturient women: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-25	Centro de Ciências da Saúde - Universidade Federal da Paraíba	Instituto Cândida Vargas	https://ensaiosclinicos.gov.br/rg/RBR-6gpvcvr	<NULL>	Women aged over 18 years; in active labor with spontaneous dilation &gt;4cm, of any parity, with two or more contractions in 10 min; with intact skin in the auricle; whose fetus is alive, in vertex cephalic presentation and with good conditions of vitality; who agree to participate in the research, with subsequent signing of the Informed Consent Form (TCLE); without serious illnesses and/or complications that consider their delivery to be high risk	Women who have too many psychiatric or neurological disorders at the time of the survey; who have a phobia of touch, who are using some integrative therapies in addition to the usual care of the obstetric service; with immediate or close indication of any surgical procedure, except cesarean section after labor; in use of analgesic medication for less than 6 hours of eligibility and admission to the research; in the latent stage of labor, who denies participating in the research and/or does not wish to sign the TCLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-7twgjp6	Clinical evaluation of polymp active zinc to decrease dentinal hipersensibility	Not yet recruiting	Intervention	2023-08-28	<NULL>	<NULL>	6397	Clinical evaluation of polymp active (Zn) to decrease dentinal hipersensibility	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Andres Felipe felipe Millan Cardenas	Centro Universitário de Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-7twgjp6	<NULL>	Good oral and general health; be at least 18 years of age; probing depth less than 3 millimeters, dentin sensitivity; have at least 2 teeth and a maximum of 4 teeth with non-carious cervical lesions	Patients with advanced periodontal disease; severe or chronic periodontitis; bruxism; Pregnant or lactating participants; participants in chronic use of anti-inflammatory, analgesic or psychotropic drugs, patients with dental fractures, or with unsatisfactory restorations or deep caries or who use fixed, removable or total partial dentures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-4mvny8s	Sedation using Ketofol versus Fentanyl + Propofol in patients undergoing Lower Gastrointestinal Endoscopy: a randomized trial	Terminated	Intervention	2023-08-26	<NULL>	<NULL>	6389	Ketofol versus Fentanyl + Propofol for sadation in patients submitted to Colonoscopy: a randomized study	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2022-07-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-4mvny8s	<NULL>	After approval by the Research Ethics Committee of the Hospital and the Free and Informed Consent Term (APPENDIX C) signed, patients aged 18 to 65 years, ASA I-II, undergoing elective colonoscopy in a private hospital in São Luís - MA.	Patients who refuse to participate or who have: pregnancy, active gastrointestinal bleeding, ASA III-V, history of hypersensitivity to the drugs used in this research, epilepsy, severe heart failure, severe respiratory failure, increased intracranial pressure and /or hemodynamic instability such as peripheral oxygen saturation ≤ 90%, systolic blood pressure (SBP) &lt; 60 mmHg and heart rate ≤ 40 bpm.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-10jytbhj	Effects of a swallowing maneuver on the risk of choking in patients with partial laryngeal surgery.	Recruitment completed	Intervention	2023-08-26	<NULL>	<NULL>	6390	Impacts of the shaker maneuver on the risk of aspiration in patients undergoing open partial horizontal laryngectomy	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2020-06-06	Instituto Nacional do Câncer - INCA	Instituto Nacional do Câncer - INCA	https://ensaiosclinicos.gov.br/rg/RBR-10jytbhj	<NULL>	Patients from the Head and Neck Sector of INCA will be included. They performed all oncological treatment at the institution. Undergoing partial laryngectomy reconstructed with CHEP; with or without adjuvant radiotherapy. Who concluded radiotherapy at least 6 months ago until the moment of the speech therapy intervention of the study. Patients capable of carrying out the strategies requested for the study on their own; both physically and cognitively. Available to come to consultations once every two weeks for clinical evaluation, monitoring of exercise performance and guidance on proper execution at home.	Are using any other alternative feeding route. Previously diagnosed central or peripheral neurological alteration that interferes with the swallowing function. Surgical or oncological intervention during the period of speech therapy intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-5ftj2fy	Effects of  Supplementation with Acid Gamma-aminobutyric associated with physical exercises at home for elderly	Recruitment completed	Intervention	2023-08-25	<NULL>	<NULL>	6388	Effects of Gamma-aminobutyric acid Supplementation combined with Physical exercises at Home on skeletal muscle mass in the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-11	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-5ftj2fy	<NULL>	60 years or older; residents in the cities of Mariana and/or Ouro Preto; present at least pre-sarcopenia level; are vaccinated against Covid-19; commit to receiving the physical education professional assigned to do the training in their homes; maintain a regular frequency of at least 80% of training sessions	Not being in the situation described in the inclusion criteria; refuse to sign the TCLE; not completely responding to the research instrument; not showing interest in participating in the intervention; have any food allergies to GABA supplementation; food allergy to rice germ and gelatin; present severe cardiovascular alterations; present severe renal alterations; have dementia; present Parkinson&apos;s disease; present severe neuropsychological alterations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-9fz4tys	Acute influence of photobiomodulation on muscle power and cardiovascular variables in physically active subjects undergoing submaximal exercise test	Recruitment completed	Intervention	2023-08-24	<NULL>	<NULL>	6382	Acute influence of intravascular laser irradiation of blood (ILIB) on muscle power and cardiovascular variables in physically active subjects undergoing submaximal exercise test	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-07	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9fz4tys	<NULL>	Have to be a university student aged between 18 and 40 years old; must be practicing regular physical exercise for at least three months; performing moderate physical activity for 150 to 300 minutes or 75 to 150 minutes of intense physical activity per week	If is a user of a drug or substance that has a known effect on cardiovascular aspects; If has a musculoskeletal or cardiovascular disease; If uses alcohol, tobacco, or caffeine for 12 hours before the assessment steps; If had practice physical activity in the 24 hours before the initial and final assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-2kqnj2t	Effects of Probiotic supplementation associated with Tube Feeding on Infections and Blood Sugar control of patients in intensive care unit	Recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6383	Effects of Probiotics supplementation associated with Enteral Nutrition on Infectious Complications and Glucid Metabolism of patients in intensive care: a prospective, randomized, placebo-controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Federal do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2kqnj2t	<NULL>	ndividuals of both sexes; aged 18 years or older; who are hospitalized in an intensive care unit; who have indication of enteral nutrition via nasogastric, nasoenteral or gastrostomy tube will be included	Individuals who do not present hemodynamic conditions to receive enteral diet, patients with lesions in the gastrointestinal tract that make it impossible to receive enteral diet, patients who are in palliative treatment, who undergo immunosuppressive treatment, who have heart valve prosthesis or valve graft, who have a history of endocarditis, history of rheumatic fever, recent postoperative period of intestinal anastomosis, biliary tract and pancreas surgery, intestinal ischemia, patients with hematological and rheumatological diseases, as recommended by the 2018 Brazilian guideline for nutritional therapy in critically ill patients (BRASPEN, 2018)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-6xgzhpy	Effect of a period without and with smartphone use and continuous aerobic exercise on levels of anxiety and anger	Not yet recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6384	Comparison of the acute effect of a period without smartphone use with a period with smartphone use and continuous aerobic exercise on levels of state-anxiety and state-rage	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-05	Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6xgzhpy	<NULL>	Age between 18 to 40 years; both genders; have your own cell phone with internet access	Contraindication for performing physical activity (PAR-Q); participants who are menstruating; pregnant participants; dysfunction (cardiac, endocrine, orthopedic and metabolic) that negatively influences the participants&apos; performance; anxiolytic treatment of any kind; and illiterate participants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-78gvj3g	Early refeeding after cesarean section: assessing the return of gastrointestinal function	Data analysis completed	Intervention	2023-08-24	<NULL>	<NULL>	6385	Early refeeding after cesarean section in a private hospital in Maceió: impact on the health of the maternal-fetal binomial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-06	Faculdade de Medicina da Universidade Federal de Alagoas	Unimed Maceio Cooperativa de Trabalho Medico (Hospital UNIMED)	https://ensaiosclinicos.gov.br/rg/RBR-78gvj3g	<NULL>	Parturients undergoing cesarean section; aged between 18 and 45 years; who were submitted to spinal anesthesia, under aseptic technique, followed by median puncture in the vertebral space between the third and fourth lumbar vertebrae with a 27G Whitacre needle, flowing clear cerebrospinal fluid and intrathecal injection of heavy bupivacaine 12.5mg plus morphine 60mcg	Patients with twin pregnancies; those with comorbidities resulting from pregnancy; patients with any type of perioperative intercurrence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-78y8prn	Comparison between electrical stimulation of the muscle with needles and electrical stimulation of the muscle with electrodes to prevent loss of strength and muscle in severe adult patients hospitalized in the Intensive Care Unit.	Recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6386	Comparison between neuromuscular electrostimulation by acupuncture and neuromuscular electrostimulation conventional in the prevention of muscle mass loss in critical adult patients hospitalized in intensive care unit: a simple blind randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Alex Blank de Paula	Silvia Ataides Alves Santana	https://ensaiosclinicos.gov.br/rg/RBR-78y8prn	<NULL>	Volunteers who give consent to participate in the research with the signature of the consent form by the legal guardian for the patient to participate in the research, both genders, age between eighteen and fifty years, time of use of Invasive Mechanical Ventilation less than twenty-four hours in the first evaluation, not be previously bedridden,; have no confirmed or suspected diagnosis of neuromuscular disease.	Volunteers who evolve with death, extubation or transfer after having started the protocol less than three days ago, and volunteers in whom the family withdraws consent to participate in the research at any time.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-6fhv7x5	Analysis of clinical, humanistic and economic outcomes of patients with anxiety using herbal medicines	Not yet recruiting	Intervention	2023-08-24	<NULL>	<NULL>	6387	Analysis of clinical, humanistic and economic outcomes of patients with anxiety using Passiflora sp.	<NULL>	4, n/a, n/a	4	<NULL>	<NULL>	<NULL>	2023-10-15	Universidade Federal de Alfenas- MG	Universidade Federal de Alfenas- MG	https://ensaiosclinicos.gov.br/rg/RBR-6fhv7x5	<NULL>	The study population will consist of people aged ≥ 18 years, without gender restriction, who sought pharmaceutical care at a university pharmacy with a main complaint of anxiety or symptoms that characterize anxiety.	Patients who do not adhere for any reason to the treatment with the proposed herbal medicine during the three months of follow-up in this study will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-8fw6zx6	Effect of Exercise and Respiratory Muscle Training in patients with Heart Failure and Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2023-08-23	<NULL>	<NULL>	6375	Effect of Physical Exercise and Inspiratory Muscle Training on Functional Capacity in patients with Heart Failure coexisting with Chronic Obstructive Pulmonary Disease: a controlled clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Instituto de Cardiologia do RS / Fundação Universitária de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-8fw6zx6	<NULL>	Patients between 50 and 85 years of age; of both sexes; who consent to participate by signing the Free and Informed Consent Form (TCLE); have a clinical diagnosis of heart failure (HF) (ventricular ejection fraction left lower than 50%, secondary to ischemic disease or cardiomyopathies), functional class II and III, according to the New York Heart Association Functional Classification for Heart Failure (NYHA), without associated pulmonary disease; having a clinical diagnosis of chronic obstrutive pulmonary disease (COPD), Global Initiative for Chronic Obstrutive Lung Disease (GOLD) II (50-79% predicted FEV1) and III (30-49% predicted FEV1), based on spirometric evaluation; be clinically stable, in the 30 days prior to inclusion in the study; not having participated or being participating in a rehabilitation program in the three months prior to recruitment	Patients who have an insufficient level of understanding to perform the tests; manifest limitations to perform physical exercise (exacerbation of fatigue, dyspnea on minimal exertion, claudication, unstable angina, uncontrolled arrhythmia); present limiting musculoskeletal diseases; disabling neuropsychiatric diseases; clinical decompensation or recent hospitalization for symptomatic control; coronary event in the last 12 months; aneurysm; patients with a history of spontaneous pneumothorax; history of collapsed lung due to a traumatic injury and that has not completely healed; history of ruptured eardrum that is not completely healed or any other disease in the eardrum; patients with asthma who have frequent attacks; patients who do not adhere to the schedule of activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-4qcx7g3	Effect of High Intensity Training on immune and cardiovascular responses in people living with HIV	Recruiting	Intervention	2023-08-23	<NULL>	<NULL>	6376	Acute effect of High Intensity Interval Training on immunological parameters, risk of infection and cardiac autonomic control of people living with HIV: A randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4qcx7g3	<NULL>	Men with HIV who have started antiretroviral therapy for at least 6 months; medical certificate releasing the practice of physical exercise; age between 18 and 40 years; physically active; and cell count of T lymphocytes cluster of differentiation 4 (T CD4) above 350 cells/mm³. For subjects without HIV, all criteria for people living with HIV will be used, with the exception of antiretroviral therapy and presence of HIV	People with HIV who have some musculoskeletal limitation that prevents them from carrying out the exercise; cardiovascular diseases; illicit drug users and/or smokers; alcoholics; do not comply with recommendations for carrying out assessments; and who do not complete the experimental protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-7hmxnkm	Postoperative analgesia in gynecological laparoscopy: intraoperative methadone or magnesium sulfate	Not yet recruiting	Intervention	2023-08-23	<NULL>	<NULL>	6377	Post-Laparoscopic gynecological analgesia: Methadone x Magnesium Sulfate. Randomized clinical trial	<NULL>	3, non-randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-09-01	Real e Benemérita Associação Portuguesa de Beneficência	Real e Benemérita Associação Portuguesa de Beneficência	https://ensaiosclinicos.gov.br/rg/RBR-7hmxnkm	<NULL>	Patients scheduled for medium-sized gynecological surgical laparoscopy (hysterectomy, oophorectomy, salpingectomy, endometriosis, without intestinal involvement, without inflammatory disease); who freely agree to sign the consent form and participate in the study	Cases that evolve with serious surgical complications (organ damage, hemorrhage, etc.); widening of the interval between the Q and T waves on the electrocardiogram; heart block other than first-degree atrioventricular block; renal failure; alteration in neuromuscular function; chronic pain in treatment with corticosteroids and/or opioids; allergy/contraindication to any of the study components	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-23j9msk	Dentin Remineralization using a Composite containing Calcium and Phosphate associated to a mineral precursor	Recruiting	Intervention	2023-08-23	<NULL>	<NULL>	6378	Dentin remineralization using a composite containing calcium orthophosphate particles associated to a mineral precursor in liquid phase (polymer-induced liquid-precursor, PILP): randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-21	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23j9msk	<NULL>	Children aged between six and nine years; both sexes; good general health; presence of at least one active carious lesion on the occlusal surface of the primary molar classified as International Caries Detection and Assessment System (ICDAS) 5 or 6 scores;  final stages of their physiological root resorption with permanent tooth sucessor presenting 2/3 of the formed root	Presence of symptoms of irreversible pulp injury (spontaneous pain or pressure); pulp exposure; fistula; soft tissue edema and abnormal mobility; presence of radiolucent areas in the interradicular/periapical regions; internal and external dentin resorptions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-9zk7qx2	Effect of Manual Techniques on the cervical and lumbar spine on pain and joint range of motion in individuals with Neck Pain and Nonspecific Low Back Pain	Recruitment completed	Intervention	2023-08-23	<NULL>	<NULL>	6379	Effect of Myofascial Release, Manipulation and Joint Mobilization of the cervical and lumbar spine on pain and joint range of motion in individuals with Neck and Nonspecific Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Faculdade de Ceilândia da Universidade de Brasília	Faculdade de Ceilândia da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9zk7qx2	<NULL>	Age between 18 and 50 years old; gender masculine and feminine; medical and imaging diagnosis of non-specific low back pain; not using psychoactive or special control medication; not undergoing physiotherapeutic or similar treatment at the time of the research	Being pregnant; history of spine fracture and/or surgery; history of osteoporosis, disc disease with radiating pain, instabilities; presence of decompensated or untreated chronic diseases; history of tumor or cancer in the spine, pelvic organs and/or gastrointestinal tract; skin problems such as mycoses, recent injuries, psoriasis, cuts and dermatitis; other physical alterations that prevent carrying out the proposed treatments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-3fmypq3	Influence of Combined Training (Power Training + Cognitive Training) on physical and cognitive function	Recruiting	Intervention	2023-08-23	<NULL>	<NULL>	6380	Influence of Power Training with Cognitive Task, Dual Task, on morphofunctional, physical, cognitive and hormonal aspects in robust older adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-28	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3fmypq3	<NULL>	Age equal or superior to 60 years; not part of a structured or systematic program of physical exercises; have a score equal to or higher than 20 points in the mini mental state examination (MMSE); walk independently; make available for the participation of a four-month exercise program	Physical and / or cognitive impairment to prevent physical exercise; history of heart disease (e.i. acute myocardial infarction), neurological (e.g. Alzheimer&apos;s disease), psychiatric (e.i. schizophrenia),cerebrovascular (e.i. cerebrovascular accident) or metabolic (e.i., diabetes mellitus I); not comply with a minimum of 90% of the total frequency of activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-5qmxt6m	Executive functions and COVID	Recruiting	Observational	2023-08-22	<NULL>	<NULL>	6366	Assessment of executive functions in long COVID	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade do Oeste Paulista	Felipe Viegas Rodrigues	https://ensaiosclinicos.gov.br/rg/RBR-5qmxt6m	<NULL>	Medicine undergraduate students; adults	psychiatric disorders prior to the COVID-19 episode; with known neurological pathologies; dyschromatopsia; have intoxication by narcotic or psychostimulant; no RT-PCR and/or rapid test for diagnostic confirmation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-8vyxcfk	Effect of 0.12% Chlorhexidine mouthwash and 5% Malva sylvestris solution on dental plaque and gingival inflammation	Recruiting	Intervention	2023-08-22	<NULL>	<NULL>	6367	Antiplaque and antigingivitis efficacy of 0.12% Chlorhexidine mouthwash and 5% Malva sylvestrais: A randomized crossover clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-08	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-8vyxcfk	<NULL>	systemically healthy; both sex; over 18-year-old; with more than 19 teeth present	Presenc of allergies to the components/products used (chlorhexidine digluconate 0.12%, Malva sylvestris extract 5%); use of 0.12% chlorhexidine digluconate or other mouthwash in the last 21 days; use of fixed and/or removable prostheses; being under orthodontic treatment; presence of caries lesion; presence of esthetic or poorly adapted restorations; presence of lesions on the oral mucosa; presence of active infectious focus (endodontic abscesses); presence of marginal gingival bleeding more than 10%; history of periodontitis (interproximal attachment loss more than 3mm in two or more non-adjacent teeth); presence of diabetes or immunosuppression; pregnant or breast-feeding patients; smokers; use of local or systemic antimicrobials in the last 90 days.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-6xkzrfy	Effectiveness of tea made from Cissampelos sympodialis leaves in the treatment of anxiety and depression: a controlled clinical trial	Data analysis completed	Intervention	2023-08-22	<NULL>	<NULL>	6368	Infusion of the leaves of Cissampelos sympodialis Eichl. and auriculotherapy: modulation of anxiety and depressed mood	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-01-25	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-6xkzrfy	<NULL>	Adults aged at least 18 years old; physically and psychologically able to talk to the interviewers; intellectual and cognitive capacity to complete the questionnaires. They must attend the CRAS.	Pregnant women; nursing mothers; kidney disease patients; liver disease patients; use of psychotropic drugs; do not have the ability to understand and answer the questionnaires; sleeping during the intervention; refuse to receive the interventions; refuse to answer questions; refuse to sign the Term of Free and Clarified Consent (TCLE); Individuals whose external ear presents anatomical variations that make it difficult to locate the auricular points.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-97htg84	Effects of Red Propolis Dry Extract Supplementation in Patients with Metabolic Syndrome	Recruiting	Intervention	2023-08-22	<NULL>	<NULL>	6370	Effects of Red Propolis Dry Extract Supplementation on biochemical blood parameters in patients with Metabolic Syndrome: a randomized, double-blind, controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-17	Centro Universitário Cesmac	Centro Universitário Cesmac	https://ensaiosclinicos.gov.br/rg/RBR-97htg84	<NULL>	Adults of either sex who have at least three of the five following items: waist above 102 cm in men and above 88 cm in women; triglycerides above 150mg/dL; HDL cholesterol below 40 mg/dL for men and below 50 mg/dL for women; blood pressure above 130/85 mmHg; fasting blood glucose above 110 mg/dL	Pregnant women; lactating women; allergic to any component of the supplement dry extract of red propolis; cancer patients; chronic renal patients; psychiatric patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-9hyhm9c	Multicenter quasi-experimental clinical trial to evaluate the efficacy of pharmacotherapeutic intervention on clinical outcomes in liver failure	Not yet recruiting	Observational	2023-08-22	<NULL>	<NULL>	6372	Quasi-experimental pre-post-implementation, multicenter trial for evaluation of efficacy of pharmacotherapeutic interventions for the identification and reporting of drug-related problems in patients hospitalized for moderate and severe liver failure in improving outcomes Clinical	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2024-01-01	Centro de Ciências de Saúde - UFRN	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-9hyhm9c	<NULL>	Age over 18 years; both sexes; hospitalized at Onofre Lopes University Hospital for chronic liver disease as the main diagnosis or as a comorbidity; clinical and laboratory signs of moderate or severe liver failure defined by Child-Pugh class B or C; signing of the Free and Informed Consent Form	Hospitalization for adverse reaction; discharge from hospital less than 3 months ago; hospitalization only for diagnostic procedure (e.g. liver biopsy) or procedure (e.g. esophageal variceal binding); patients transferred from another hospital or department; patients previously included in this study; diagnosis of metastatic liver, hepatocellular carcinoma, cholangiocarcinoma, sclerosing cholangitis, primary biliary cholangitis, hemochromatosis, Wilson&apos;s disease, zoonoses (echinococcosis, amebiasis, schistosomiasis, fasciolosis); acute hepatitis of viral, alcoholic, autoimmune, toxic, or gestational etiology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-7hx3f22	Efficacy of preventive pain medication for Foot and Ankle surgery	Recruitment completed	Intervention	2023-08-22	<NULL>	<NULL>	6373	Efficacy of preventive analgesia in Foot and Ankle surgery	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2020-10-01	Instituto Nacional de Traumatologia e Ortopedia	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-7hx3f22	<NULL>	patients with degenerative hindfoot diseases with indication of hindfoot modeling arthrodesis	Latex allergy; allergy to etoricoxib; gabapentin allergy; chronic opioid use syndrome; acute hindfoot injury; rheumatic diseases; history of Complex Regional Pain Syndrome; neoplastic disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-7kym6v8	Neuromodulation on clinical outcomes in patients on Hemodialysis	Recruiting	Intervention	2023-08-22	<NULL>	<NULL>	6374	Alternating sessions of Transcranial Direct Current Stimulation on clinical outcomes in patients on Hemodialysis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-10	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7kym6v8	<NULL>	Patients of both genders with chronic kidney disease diagnosed by the glomerular filtration rate or albuminuria for more than 3 months; be undergoing hemodialysis procedures at least 3 times a week for more than 3 months and for 4 hours per session; be over 18 years old; have chronic pain greater than 3 according to the visual numerical scale for more than 3 months; no anemia; no class III and IV heart failure according to the New York Heart Association classification; no history of cerebrovascular or peripheral arterial disease	Having metallic implants in the head; decompensated diabetes mellitus; hypertension; history of dizziness or epileptic disorders; signs of severe illness and/or hemodynamic instability and pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-8tv29dc	Effects of Pulmonary Rehabilitation on the perception of happiness in individuals with Chronic Obstructive Pulmonary Disease	Recruitment completed	Intervention	2023-08-22	<NULL>	<NULL>	7596	Effects of Pulmonary Rehabilitation on the degree of happiness of patients with Chronic Obstructive Pulmonary Disease compared to usual care: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Juiz de Fora	Hospital Universitário da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8tv29dc	<NULL>	Individuals with a diagnosis of Chronic Obstructive Pulmonary Disease (COPD); without any other respiratory diseases; of both sexes; aged 18 years or older; clinically stable; without unstable cardiovascular diseases; without neurological disorders; without musculoskeletal diseases; and capable of undergoing the proposed assessments and interventions	Individuals who experience respiratory, cardiovascular, or musculoskeletal complications during assessments and interventions; exacerbation of pulmonary disease; the need for hospitalization; individuals who express their desire to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:26
RBR-3jpnxqw	Use of Citicoline in Children with Attention Deficit Hyperactivity Disorder	Data analysis completed	Intervention	2023-08-21	<NULL>	<NULL>	6364	Use of Citicoline in Attention Deficit Hyperactivity Disorder - randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade do Vale do Taquari  - Univates	Universidade do Vale do Taquari  - Univates	https://ensaiosclinicos.gov.br/rg/RBR-3jpnxqw	<NULL>	Diagnosis of Attention Deficit Hyperactivity Disorder according to DSM-5 criteria, confirmed by the investigator&apos;s judgment. Age between 7 and 12 years old.  Both genders. Subjects using psychopharmacological treatment considered adequate by the investigator, in a stable dose for at least 4 weeks before inclusion, with no need to adjust the dose throughout the study	Other comorbidities that influence the neuropsychological assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-8tqb4p7	The ear test program from the perspective of family members and professionals: analysis of the satisfaction and impact of an educational intervention	Recruitment completed	Intervention	2023-08-21	<NULL>	<NULL>	6365	The Neonatal Hearing Screening program from the perspective of family members and professionals: analysis of the satisfaction and impact of an educational intervention	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8tqb4p7	<NULL>	Parents or guardians of babies; cared at Januário Cicco Maternity School; with or without risk indicators for hearing impairment;  with or without newborn hearing screening; health professionals from study local; work during the day in the rooming-in or in the kangaroo unit; who agree to participate in the study	Refusal to participate in the study; individuals under the age of 18; did not complete the questionnaires;  professionals in the administrative sector; professionals who work exclusively at night	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-359p69v	AtivaRS project: Exercise Practice to reduce Sedentary Behavior in the population	Not yet recruiting	Intervention	2023-08-21	<NULL>	<NULL>	6552	AtivaRS project: Combating Sedentary Lifestyle	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade do Vale dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-359p69v	<NULL>	Sedentary individuals; aged between 20 and 60 years; with no medical contraindications for physical exercise; must own a smartphone; agree to participate in the research by signing the informed consent form	Individuals who experience angina during exertion; history of acute myocardial infarction within the 12 months prior to the start of the protocol; require oxygen supplementation; exhibit clinical instability in the month preceding the protocol initiation; uncontrolled hypertension; visual diseases that prevent the performance of the protocol; chronic conditions  hindering participation in the exercise protocol; illiterate; refuse to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-4tfwdhp	Comparison of the effects of walking in a suggested environment and free walking for people with Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2023-08-21	<NULL>	<NULL>	7352	Ecological determinants of active behavior of people with Chronic Obstructive Pulmonary Disease and effects of walkability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-29	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-4tfwdhp	<NULL>	Individuals with a confirmed diagnosis of Chronic Obstructive Pulmonary Disease (COPD) will be studied based on the criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD); of both sexes; with the post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ratio being &lt;70% and FEV1 &lt;80% of the predicted value 29; aged over 18 years; clinically stable; without unstable cardiovascular diseases; neurological; musculoskeletal disorders and in conditions to carry out the proposed evaluations and intervention	Participants unable to perform or understand the study assessments due to physical or psychological impairment will be excluded from the study; primary diagnosis of a respiratory disease other than Chronic Obstructive Pulmonary Disease (COPD); in support of oxygen therapy; with orthopedic and/or neurological limitations that prevent the performance of the tests; recent hospitalization (last 3 months); cognitive impairment identified by a score of 4 or less on the Six Item Screener; or who expressed their desire to withdraw from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:17
RBR-6r8y39d	Ear stimuli to reduce high blood pressure in adults and the elderly	Recruitment completed	Intervention	2023-08-18	<NULL>	<NULL>	6359	Auriculotherapy and its effect on pressure levels in adult and elderly hyperensive patitents	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal de Mato Grosso - Campus Cuiabá	Hospital Universitário Júlio Müller	https://ensaiosclinicos.gov.br/rg/RBR-6r8y39d	<NULL>	Medical diagnosis of systemic arterial hypertension; who agree to participate in the research; who are available to attend the application site to receive auriculotherapy	Presence of infection, inflammation or injury in the ear; presence of piercing in the ear (except normal earring); tape allergy; being pregnant, being in the puerperium and/or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-6y85xgt	Effect of training associated with simulated altitude on blood, autonomic, aerobic and anaerobic parameters of amateur runners	Recruitment completed	Intervention	2023-08-18	<NULL>	<NULL>	6360	Effects of training associated with recovery hypoxia and tapering on hematological, autonomic, aerobic and anaerobic parameters on amateur runners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6y85xgt	<NULL>	Physically active men; age between 18 and 35 years	Limitations to high-intensity physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-10t3wc7z	Development and evaluation of flexible sensor devices and construction of plasmid positive controls for molecular diagnosis and detection of residual disease in Leukemia	Not yet recruiting	Observational	2023-08-18	<NULL>	<NULL>	6361	Accuracy of a flexible nanodevice based on DNA probes and conductive polymers for ultrasensitive diagnosis of chimeric oncogenes associated with childhood Lymphocytic Leukemia in health units in Brazil and therapeutic decision under the Brazilian Childhood Leukemia Treatment Group (GBTLI) protocol - 2020	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-10-01	Instituto Aggeu Magalhães - Fiocruz de Pernambuco	Instituto de Medicina Integral Prof. Fernando Figueira - IMIP	https://ensaiosclinicos.gov.br/rg/RBR-10t3wc7z	<NULL>	Patients with a maximum age of 20 years; both genders; attended at reference services for the treatment of leukemia in Brazil with a clinical and cytological diagnosis of leucemia; who express the desire to participate in the project and the legal guardians sign the Free and Informed Consent Form and the children between 8 and 18 years old sign the Free and Informed Assent Term, providing clinical information, and allowing the analysis of samples (bone marrow) in the laboratory reference of the study in Recife	Patients with mature B-cell Leukaemia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-5bq9jh3	Effects of group training in elderly women with knee osteoarthritis	Not yet recruiting	Intervention	2023-08-18	<NULL>	<NULL>	6362	Effects of group training on clinical and functional aspects in elderly women with knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5bq9jh3	<NULL>	Women; age between 60 and 80 years; diagnosis of osteoarthritis of the knee according to the criteria of the American College of Rheumatology; osteoarthritis of the medial femorotibial knee on radiography classified as grades 2 or 3 according to the Kellgren and Lawrence criteria (1957); mean knee pain score between 4.0 and 9.0 on the Numerical Pain Scale (NRS);	Body mass index greater than or equal to 30 kg/m2; cognitive deficits screened by the mini-mental state examination; being in current treatment with physiotherapy or doing regular physical exercise (more than twice a week) in the last 6 months; history of joint infiltration in the last 3 months or planning to receive infiltration in the next 6 months; history of knee or hip arthroplasty; history of knee surgery in the last 6 months or planning to undergo surgery in the next 6 months; presence of other illnesses that threaten safety or prevent participation in interventions or tests (symptomatic or severe coronary artery disease; dementia; use of walking aids; other types of arthritis such as rheumatoid arthritis); history of knee trauma in the last 30 days; inability to perform training protocol (inability to walk short distances or need assistance from another person to complete activities of daily living);	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-9vpj5gc	Physical Training and reduction of Exercise-Induced Bronchospasms	Recruiting	Intervention	2023-08-18	<NULL>	<NULL>	6363	Effects of a Physical Training Program on the reducing of Exercise-Induced Bronchospasms, Physical Fitness and Quality of Life in Asthmatic Adolescents: a clinical test	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-11	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-9vpj5gc	<NULL>	Adolescents aged 10 to 19 years; with a diagnosis of asthma classified according to the criteria of the Global Initiative for Asthma; they should not be involved in a physical exercise program; is in a stable phase of the disease, without exacerbation or change of medication in the last 30 days; have a forced expiratory volume in one second below 80 percent of predicted.	Cardiac teenagers; with neurological disorders or who have complications in their disease status during the collection phase.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-2k6xxs7	Effects of Senior Dance® on the Elderly	Recruitment completed	Intervention	2023-08-18	<NULL>	<NULL>	6590	Effects of Senior Dance® in elderly people with and without dementia: controlled clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Faculdade de Medicina de Marília	Faculdade de Medicina de Marília	https://ensaiosclinicos.gov.br/rg/RBR-2k6xxs7	<NULL>	Elderly of both sexes; aged 60 to 85 years; wheelchair users or not; elderly with cognitive decline according to the Mini Mental State Examination (MMSE) assessment for group G1 belonging to long-stay institutions; elderly without cognitive impairment according to the Mini Mental State Examination (MMSE), non-institutionalized for group G2	Bedridden or seriously ill elderly; seniors with medical restrictions to exercise; elderly with recent fractures and/or in the process of immobilization; elderly with grade 2 and 3 dementia by CDR; seniors with less than 3 years of schooling; elderly unable to respond verbally to the scales/questionnaires; elderly with a previous diagnosis of psychiatric disorders of non-neurodegenerative characteristics; refusal to sign the Free and Informed Consent Term and/or Free and Informed Assent Term; not attending 75% of classes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-3n7pzqt	Analysis of the Effectiveness of the Anti-motion Sickness Glasses for Reading in Vehicles	Data analysis completed	Intervention	2023-08-17	<NULL>	<NULL>	6358	Validation of Antikinetosis Sickness Glasses for Reading in Vehicles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-03	APEC - Sociedade Potiguar de Educação e Cultura S.A	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-3n7pzqt	<NULL>	Being a student at the Universidade Potiguar; having signs or symptoms of motion sickness while reading in vehicles; not being under the use of antikinetosis medication; be at least 18 years old.	The exclusion criterion is not meeting all the inclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-3dp727r	Effects of Exercise Training with body weight in Hypertensive individuals	Not yet recruiting	Intervention	2023-08-16	<NULL>	<NULL>	6355	Acute and chronic effects of Exercise Training with body weight in Hypertensive individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de São Paulo	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-3dp727r	<NULL>	The inclusion criteria will include individuals who: are male; are hypertensive through a previously requested medical report; whose hypertension is controlled by medication; are between 30 and 50 years old; have been sedentary for at least a period of 6 months; hold medical clearance to practice physical exercise; do not present injuries that limit the partial or total practice of physical exercise; agree to be volunteers for the realization of this project; provide personal and health information; perform pre-participation assessments of the exercise program; sign the free and informed consent form (TCLE)	Participants who change their drug treatment during their participation in the research and who, during the 17-week training period, have a frequency below 75% will be excluded from the analyses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-8s8tz32	Risperidone and Clonazepam combined by oral solution with intramuscular Haloperidol Agitation by Psychosis	Data analysis completed	Intervention	2023-08-16	<NULL>	<NULL>	8038	Comparison of Risperidone and Clonazepam combined by oral solution with intramuscular Haloperidol as monotherapy in psychomotor agitation of psychotic patients	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-12-01	Universidade Federal do Tocantins	Universidade Federal do Tocantins	https://ensaiosclinicos.gov.br/rg/RBR-8s8tz32	<NULL>	Patients in psychomotor agitation scored by the Behavioral Activity Rating Scale (BARS)=6; who did not use any psychoactive drugs in the last 7 days; with mental illness; patients with psychotic disorder or bipolar disorder; age between 18 and 50 years old; both sexes	Acute intoxication states; delirium;  withdrawal syndrome; mental disorder of organic origin; refusal to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-28xttdt	Effects of ear Acupuncture on the mental health of nursing professionals	Not yet recruiting	Intervention	2023-08-15	<NULL>	<NULL>	6353	Effects of Chinese Auricular Acupuncture on Compassion Fatigue and emotional health of nursing professionals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Hospital Universitário Júlio Muller	Hospital Universitário Júlio Muller	https://ensaiosclinicos.gov.br/rg/RBR-28xttdt	<NULL>	nursing professionals with at least 6 months of practical experience; who work in sectors that provide direct care to patients; that you have answered all the questions in the questionnaires; who have available time to participate in the stages of the research, and who agree to participate in the research by signing the Free and Informed Consent Term	having a previously diagnosed severe psychiatric disorder in continuous use of psychotropic medications; being pregnant, on vacation, or on leave during the intervention period; act only in administrative functions; presenting skin lesions, infection, inflammation or injury to the ear; allergic to adhesive tape in the pavilion; excessive oiliness in the ear; use a hearing aid; use steroidal anti-inflammatory drugs or opioid analgesics; to have  coagulation disorders, or to use anticoagulants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-6p5bvvg	The CHANGE Project: creating a multidimensional assessment model for hospitalized older adults	Recruiting	Observational	2023-08-15	<NULL>	<NULL>	6354	The CHANGE Project: hospital assessment model for older adults in a multicentric multidimensional care network	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-05-06	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Ensino e Pesquisa do Hospital Sírio Libanês	https://ensaiosclinicos.gov.br/rg/RBR-6p5bvvg	<NULL>	Adult volunteers aged 65 and over; both genders; hospitalization under the responsibility of study investigators or sub-investigators; completion of admission assessment in the first 48 hours of hospitalization; signed informed consent form	Adult volunteers with an admission Clinical Frailty Scale (CFS) score of nine (terminal patients in exclusive palliative care)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-4dmj9xj	Immediate effect of electrical stimulation of the vagus nerve in the ear region in improving heart rate variation in active elderly women	Recruitment completed	Intervention	2023-08-15	<NULL>	<NULL>	7093	Acute effect of transcutaneous auricular vagus nerve stimulation on heart rate variability in active lderly people: a randomized, crossover, blind, controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-09	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-4dmj9xj	<NULL>	Women; age 60 to 75 years; reside in the state of Rondônia; attend a senior center; do not smoke; non-cardiac patients; non-diabetic; untreated hypertension; and who agreed to participate in the study by signing the Free and Informed Consent Form	Participants who are unable to perform the tests; do not attend intervention sessions; voluntarily gave up completing the protocol; have a respiratory rate lower than 7 rpm during assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-10bzg6v2	Usability of a 3D Printed Face Shield Prototype for Intensive Care Professionals: Pragmatic Clinical Trial	Not yet recruiting	Intervention	2023-08-14	<NULL>	<NULL>	6344	Usability Evaluation of a High Fidelity Face Shield Prototype Developed for Intensive Care Health Professionals: Pragmatic Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-30	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10bzg6v2	<NULL>	Nursing professionals working in intensive care units	Professionals on probationary period (less than 3 months in the hospital); professionals in the process of dismissal (with prior notice); pregnant professionals; intolerance or allergies (formal or declared) to face shield materials	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-93ccq38	Evaluation of two chemical agents in gingival graft surgeries	Recruiting	Intervention	2023-08-14	<NULL>	<NULL>	6346	Comparative clinical evaluation of the use of Chlorexidine and Phthalocyanine in the postoperative of Subepithelial Connective Tissue Graft	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-03	Universidade de São Paulo	Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-93ccq38	<NULL>	Patients of both genders; aged between 18 and 70 years old; clinical diagnosis of multiple gingival recessions RT1 with at least 1 gingival recession ≥ 2 mm, including canines and premolars; root surfaces without abrasion, erosion, or caries; systemically healthy patients; no contraindication for periodontal surgical procedures.	Rotated teeth; extruded or mobile teeth; smokers; pregnant and lactating individuals; history of periodontal disease or recurrent abscess formation; patients previously undergone root coverage surgical procedures; patients using medications [anticonvulsants, antihypertensives, contraceptives, or immunosuppressants]; low level of oral hygiene (plaque index and bleeding index &gt;20%)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-8w55n2g	Effects on postural control using Galvanic vestibular stimulation in spinal cord injury patients	Recruiting	Intervention	2023-08-14	<NULL>	<NULL>	6347	Galvanic vestibular stimulation in spinal cord injury: effects on postural control	<NULL>	0, non-randomized-controlled, open	0	<NULL>	<NULL>	<NULL>	2023-06-05	Universidade Metodista de São Paulo - UMESP	Universidade Metodista de São Paulo - UMESP	https://ensaiosclinicos.gov.br/rg/RBR-8w55n2g	<NULL>	Having a sensory motor sequelae such as tetraparesis/tetraplegia or paraparesis/paraplegia secondary to spinal cord injury; being older than 18 years old; both genders; being under medical follow-up for their condition; following the prescribed medical guidelines	Having  some non-compensated clinical condition; having a pressure ulcer; having a metallic implant in the skull; having seizure episodes, and having a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-23frm8c	Analysis of new measurement of Peripherally Inserted Central Catheter in neonates	Recruiting	Intervention	2023-08-14	<NULL>	<NULL>	6348	Efficacy of a new method for Peripherally Inserted Central Catheter placement in neonates in relation to the location of the device tip: a randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-02-03	Universidade Federal Fluminense	Programa de Pós-Graduação Mestrado Profissional em Enfermagem Assistencial	https://ensaiosclinicos.gov.br/rg/RBR-23frm8c	<NULL>	Peripherally inserted central catheter procedures in upper limbs; term newborns; preterm newborns; both sexes	Puncture site for catheter insertion other than in the upper limbs; insertion procedure performed in newborns with congenital anomalies of the venous network; newborns with coagulopathies; malformation in upper limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-10g7v5bx	Treatment of people with a sprained ankle at different stages of the injury	Not yet recruiting	Intervention	2023-08-14	<NULL>	<NULL>	6350	Rehabilitation of individuals with ankle sprains in their different stages	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-10g7v5bx	<NULL>	Participants must have experienced an ankle sprain within 96 hours prior to the day of evaluation; present visible swelling in the ankle region as a consequence of the sprain; at least 15 years old; both genders	People with ankle or foot fractures diagnosed after the sprain; presence of systemic or hormonal edema related to cardiac and renal problems; pregnancy; treatment with an immovable plaster cast; any reported neurological, musculoskeletal, cardiovascular, pulmonary, or metabolic conditions that may interfere with or contraindicate the research procedures will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-8t57fy2	The effect of the Brief Intervention on alcohol consumption and its relationship with the health of women who use a Primary Health Care service	Recruitment completed	Intervention	2023-08-14	<NULL>	<NULL>	6351	Effectiveness of the Brief Intervention in harmful alcohol consumption and the relation between the pattern of use and the health status of women assisted at a Primary Health Care service	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-28	Escola de Enfermagem da Universidade de São Paulo	Secretaria Municipal de Saúde de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8t57fy2	<NULL>	females over the age of 18; to have up-to-date telephone contact; speak Portuguese	Volunteers unable to communicate verbally; pregnant; transsexual women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-93v2w7b	Laser effects in patients who underwent Anterior Cruciate Ligament surgery	Recruitment completed	Intervention	2023-08-14	<NULL>	<NULL>	6352	Effects of low level laser therapy on quadriceps strength in the late postoperative period of Anterior Cruciate Ligament	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-30	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-93v2w7b	<NULL>	Individuals of both sexes, between 18 and 60 years old and who have undergone anterior cruciate ligament reconstruction surgery for at least 1 year	Not having signed the Free and Informed Consent Form, inability to understand the tests, musculoskeletal injuries that prevent the ability to walk independently, neoplastic tissue, medical contraindication to perform physical exercise and individuals with a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-3nghxq6	The Wish Card Game on the meaning of life assessment of women with incurable Cancer	Recruiting	Intervention	2023-08-14	<NULL>	<NULL>	7526	Effect of the Go Wish Cards Game on the meaning of life scores of women with Gynecological and/or Breast Cancer advanced: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Fundação PIO XII - Hospital de Amor de Barretos	Fundação PIO XII - Hospital de Amor de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-3nghxq6	<NULL>	Female patients; aged greater than or equal to 18 years; aware of the diagnosis of gynecological and/or breast cancer, with metastasis and progression of the disease; with a profile for conversations about existential and end-of-life processes that will be identified and referenced by one of the oncologists at the women&apos;s outpatient clinic or by the palliative doctor who works in unit I; estearn cooperative oncology group (ECOG) performance scale less than or equal to 3; karnofsky performance scale (KPS) greater than or equal to 40%; patients who have access to the internet and cell phones that allow video calls; patients who have cognitive conditions to understand the research (which will be evaluated by the researcher)	Patients with psychological or psychiatric disorders that prevent them from participating in the study, such as acute depression, schizophrenia, bipolar affective disorder, panic disorder, delirium, among others registered in the medical record; patients with communication limitations or reduced hearing acuity to a degree that severely hinder communication with the researcher or understanding of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:24
RBR-6t544q7	Acute effect of Myofascial Release Techniques of the legs and feet, on mobility and high of the vertical jump tests in active individuals	Recruitment completed	Intervention	2023-08-11	<NULL>	<NULL>	6333	Acute effect of Osteopathic Techniques for releasing the deep and superficial plantar fascia and the gastrocnemius on mobility and performance in vertical Jump Tests in physically active individuals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Colégio Brasileiro de Osteopatia	Colégio Brasileiro de Osteopatia	https://ensaiosclinicos.gov.br/rg/RBR-6t544q7	<NULL>	Volunteers of both genders; age between 23 and 40 years; physically active; exercise 3 times a week or more; practice resistance exercises for more than 6 months	Volunteers who are contraindicated for manual therapy. With tumors, fractures, arthritis rheumatoid, severe vascular condition), who had surgery in the lower limbs and are incapable to jump	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-2qpm3gt	Physiotherapeutic Exercises in Perineal Pain in Women with Endometriosis	Not yet recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6334	Application of a Physiotherapeutic Protocol in the Pelvic Dysfunctions of women With Deep Endometriosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2qpm3gt	<NULL>	For the groups (intervention group A and control group B), women in menacme; over 18 years old and up to 50 years old; diagnosed with deep endometriosis through surgery or diagnosed by imaging (ultrasound or MRI) will be included. performed by a specialist in the area) and hormone treatment for at least six months; who still had pelvic pain and/or dyspareunia (depth) associated or not with other pain complaints (dysmenorrhea, dyschezia and dysuria)	For both groups (intervention group A and control group B), the following exclusion criteria will be adopted: not having coitarche; spontaneous or surgical menopause; immediate gestational desire; presence of cognitive alterations that make it impossible to apply questionnaires and physical disabilities that make it impossible to apply the physical assessment techniques and perform the exercises in the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-9yy8w2k	Effect of Pain Education associated with Cyclobenzaprine in patients with Masticatory Muscular Pain: a clinical trial	Recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6335	Effect of Neuroscience-based Pain Education associated with Cyclobenzaprine administration in patients with Masticatory Myofascial Pain: a double blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-14	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9yy8w2k	<NULL>	Women; aged 18 to 60 years; diagnosed with muscular temporomandibular disorder or masticatory myofascial pain according to the Diagnostic Criteria for Temporomandibular Disorders; pain greater than or equal to 4 on the Visual Numerical Scale for at least 3 months	History of recent facial trauma within the past 2 years; gestation; continuous use of non-steroidal anti-inflammatory drugs, analgesics, antidepressants or muscle relaxants; intracranial, neurological disorders and other major causes of headache; odontogenic pain; persistent idiopathic dentoalveolar pain; orthodontics; other current treatment for temporomandibular disorders; diagnosis of fibromyalgia; hypersensitivity to cyclobenzaprine or any other component of the product&apos;s formula; any contraindication provided in the package insert for the use of cyclobenzaprine; non-acceptance to voluntarily participate in the research or refusal to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-8kn94q4	Galvanic vestibular stimulation and human-human interface in the spinal cord injury patient	Recruitment completed	Intervention	2023-08-11	<NULL>	<NULL>	6336	Galvanic vestibular stimulation and the human-human interface in chronic spinal cord injury trauma: a case study	<NULL>	0, single-arm-study, open	0	<NULL>	<NULL>	<NULL>	2022-03-25	Universidade Metodista de São Paulo - UMESP	Universidade Metodista de São Paulo - UMESP	https://ensaiosclinicos.gov.br/rg/RBR-8kn94q4	<NULL>	Male gender; having tetraparesis secondary to chronic spinal cord trauma; be over 18 years of age; be under medical follow-up for your condition; be following prescribed medical guidelines	Having  some non-compensated clinical condition; having a pressure ulcer; having a metallic implant in the skull; having seizure episodes, and having a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-3w739vq	Immediate improvement in symptoms with the use of a foot pad in runners with knee pain is associated with changes in lower limb movement	Recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6337	Is the immediate improvement in symptoms with the use of a foot orthosis in runners with patellofemoral pain associated with changes in lower limb kinematics assessed using principal component analysis?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-10	Universidade Federal de São Carlos - UFSCar	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-3w739vq	<NULL>	Having previous experience in running, on an ergometric treadmill and running at least 10 km per week for at least 3 months; have a running pattern with rearfoot landing; age between 18 and 45 years; both genders; anterior or peripatellar pain during running and in two or more of the following activities: going up/down stairs, squatting, kneeling, jumping, and after sitting for long periods; insidious onset of symptoms unrelated to a traumatic incident and persisting for at least three months during running activity; usual pain in the last week of at least 3/10 on the - Visual Analog Pain Scale; and excessive subtalar pronation during running, determined through the two-dimensional analysis proposed by Pipkin et al 2016	Have used a foot orthosis or undergone physiotherapeutic treatment for PFP in the last 12 months; having meniscal or intra-articular injuries; have previous ligament injuries in the knee joint; have ligament laxity; having Osgood-Schlatter or Sinding Larsen-Johansson syndrome; present pain or current injury in the lumbar spine, hip or ankle; presenting patellar instability; presenting evidence of knee joint effusion; have a history of lower limb surgery; have reported cardiovascular alterations or present neurological impairment with influence on gait	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-6xhp399	Propofol as a protective agent in postoperative attentional changes, a prospective clinical trial	Recruitment completed	Intervention	2023-08-11	<NULL>	<NULL>	6338	Cognitive changes related to anesthetic technique	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Hospital Universitário Gaffree e Guinle	Hospital Universitário Gaffree e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-6xhp399	<NULL>	Age above18 years; both sexes; signing of the Free and Informed Consent Form about participation in the study; physical status ASA (American Society of Anesthesia) I; II and III ( one, two and three); patients undergoing general anesthesia for laparoscopic cholecystectomy and/or thyroidectomy; lasting less than 300 minutes;	ASA(American Society of Anesthesia) scale four; presence of neurological or psychiatric disease affecting cognition;  continuous use of: corticosteroids; antipsychotics; opioids, zolpiden; tricyclic antidepressants;  smoking; alcoholism; severe liver disease; renal failure (creatinine clearance under 100); inability to perform neuropsychometric tests independentes. The following perioperative situations exclude research participants: Postoperative delirium; report of anesthetic complications, including hypoxemia; hypotension and deep anesthetic plane (BIS (Bispectral Index Scale) under thirty five);  report of general anesthesia up to one year prior to surgery; previous cardiac or neurological surgeries; urgent surgeries or with intraoperative surgical complications (bleeding and reoperation)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:02
RBR-107j3g4v	The use of Pyridostigmine bromide in the treatment of fatigue secondary to COVID-19	Recruitment completed	Intervention	2023-08-11	<NULL>	<NULL>	6339	Cholinergic stimulation with Pyridostigmine bromide in the treatment of fatigue secondary to SARS-Cov2 infection	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-107j3g4v	<NULL>	Individuals with a recent history of SARS Cov2 infection, confirmed by positive PCR; age between 18 and 65 years; patients who maintain permanent symptoms, mainly fatigue, after 4 weeks of the onset of the illness	Individuals with some type of motor or mental disability that prevents the performance of the proposed tests; pregnant women; subjects with known hypersensitivity to pyridostigmine; individuals with conditions that contraindicate the use of pyridostigmine, such as glaucoma, asthma and urinary obstruction; patients with heart rhythm different from sinus rhythm, with atrial fibrillation, frequent ventricular and/or supraventricular ectopy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-728q3cp	Patients with stains on hypomineralized tooth enamel	Recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6340	Patients with hypomineralized permanent teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-728q3cp	<NULL>	Patients over 8 years old; with erupted permanent molars; molars with HMI; deep cavities or unsatisfactory restorations; pulp vitality; without periodontal disease.	Patients with periodontal disease; parafunctional habits; history of previous allergies to restorative materials; endodontic compromise; Do not sign the Term of Consent/assertion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-5snf9q3	The effect of Auriculotherapy in reducing pain in elderly people with Low back pain	Not yet recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6341	Efficacy of Auriculotherapy in reducing pain levels in elderly people with Low back pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-30	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5snf9q3	<NULL>	Elderly aged 60 years or older, of both sexes, who are being treated at the Basic Health Units, and/or attending the selected elderly centers and who accept to participate in the research by signing the Free and Informed Consent Term will be included.	Elderly people who have some physical and mental limitation to participate in the research will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-9gffcgq	Effects of a goal-oriented collaborative intervention associated with home positioning strategies for non-ambulatory children with cerebral palsy	Not yet recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6342	Effects of a goal-directed collaborative intervention with postural management strategies by telehealth in children with non-ambulant Cerebral Palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-01-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9gffcgq	<NULL>	Children aged 1-5 years with a diagnosis of cerebral palsy (CP) VERIFICAR SIGLAS , classified at levels IV and V of the Gross Motor Function Classification System (GMFCS), who receive conventional Physical Therapy 1 or 2 times a week, in the state of Minas Gerais, Brazil.	Children with clinical instability, tracheostomy or oxygen dependents; or those who had undergone surgery or botulinum toxin injections in the last six months. Those who are currently participating in an intensive physiotherapy protocol will only be included when the protocol ends and three months after they return to the Conventional Physical Therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-3j3cktx	Drug treatment of Diabetes in pregnancy	Recruiting	Intervention	2023-08-11	<NULL>	<NULL>	6431	Metformin versus insulin in the glycemic control in pregnancy	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2023-08-12	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-3j3cktx	<NULL>	Pregnant women diagnosed with diabetes type two or gestational diabetes; pregnant women that require medication for glycemic control; pregnant women that agree to participate of the study; pregnant women over 18 years old; pregnant women following in the prenatal care unit of our service	Pregnant women diagnosed with diabetes that do not require medication for glycemic control, pregnant women that cannot use any of the medication (insulin or metformin); pregnant women that refuse to participate of the study; pregnant women under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-1083qqwy	Effect of a 35% hydrogen peroxide gel containing a composite in reducing of tooth sensitivity after in-office dental bleaching	Recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6325	Effect of the use of a 35% hydrogen peroxide gel containing capsaicin and hydroxyapatite nanoparticles to reduce post-bleaching tooth sensitivity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-20	Universidade Estadual de Ponta Grossa - UEPG	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-1083qqwy	<NULL>	Patients aged between 18 and 50 years; both genders; with good oral and general health; have their maxillary anterior teeth free from restorations and carious lesions; canines with color A2 or darker according to the Classical Vita scale (Vita Zahnfabrik, BadSäckingen, Germany); to agree with the free and informed consent form	Patients who have already performed dental whitening; pregnant patients or lactating; severe browning (staining by tetracycline; fluorosis or endodontics); people with dental prostheses and orthodontic appliances and any other oral pathology; patients who have gastric, heart, kidney and liver problems; diabetes; hypertension; who are making continuous use of drugs with analgesic and anti-inflammatory action	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-825ymxq	Randomized clinical trial comparing different treatments for Dental Fluorosis	Not yet recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6327	Effectiveness of different treatment protocols for Dental Fluorosis: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-825ymxq	<NULL>	Presenting a minimum of four anterior and/or superior teeth affected by dental fluorosis in the range of 1 to 6 according to the Thylstrup and Fejerskov Index; demonstrating good oral health condition (absence of active caries or periodontal disease in the anterior and/or superior and inferior teeth); being at least 15 years of age; having good general health condition (absence of cardiac problems, hypertension, or uncontrolled diabetes); showing an interest in improving the appearance of stained teeth	Presence of structural defects on the enamel surface; loss or fracture of any upper element; evidence of significant malocclusion; pregnant or lactating individuals; individuals undergoing orthodontic treatment; history of previous dentin sensitivity; restorations involving more than 1/6 of the vestibular face of any of the six anterior and/or inferior teeth; severity of fluorosis greater than 6 according to the Thylstrup and Fejerskov Index; history of prior treatment for dental fluorosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-8g25rh4	Effect of non-invasive Brain Stimulation on functionality and concurrent tasks in people with Diabetes Mellitus: a randomized clinical trial	Not yet recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6329	Effect of Transcranial Direct Current Stimulation on functional performance and dual task of individuals with Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Educação Física e Fisioterapia da Universidade Federal do Amazonas	Faculdade de Educação Física e Fisioterapia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8g25rh4	<NULL>	adults; not elderly; diagnosed with Type 2 Diabetes Mellitus; able to walk independently without the use of a walking aid; no history of diabetic neuropathy; vestibulopathy; retinopathy; nephropathy; neurological or orthopedic disease that affects gait quality, such as poliomyelitis; Brain stroke; parkinson, cerebellar ataxia; lower limb fracture; knee or hip replacements; congenital clubfoot; Charcot arthropathy; lameness of any etiology	presence of plantar ulcers; diagnosis of epilepsy; materials surgically implanted in the head or neck; use of psychotropic medication; known allergies to tDCS preparation materials; history of psychiatric illness or previous neurosurgical procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-64b6vcw	Evaluation of the effectiveness of a software for the identification and dialogue with university students with a possible depressive profile	Recruitment completed	Intervention	2023-08-10	<NULL>	<NULL>	6330	Evaluation of the effectiveness of an interactive computational solution for the identification and dialogue with university students with a possible depressive profile	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-17	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-64b6vcw	<NULL>	Phase 1 - all students; older than 18 years; both genders; from undergraduate and stricto sensu postgraduate courses, from the four campuses of the Federal University of São Carlos - UFSCAR who have freely and clearly expressed consent via TCLE 1; Phase 2- only the first 100 volunteers with mild or moderate depression (self-diagnosed in phase 1); no suicidal ideation; who claim to have a cell phone with an operating system Android 8.0 or higher or IOS 11.0 or higher; both genders; older than 18 years; who express consent, in a free and informed manner, via TCLE 2	Not being a regularly enrolled student at UFSCar	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-7bcnk6h	Effects of Yoga on university students with symptoms of Anxiety and Depression	Recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6331	Effects of a Yoga program on oxidative stress, postural balance and quality of life of university students with symptoms of Anxiety and Depression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-7bcnk6h	<NULL>	Be a higher education student aged 18 or over; both genders; score 10 points or more on the Generalized Anxiety Disorder 7 (GAD-7) questionnaire that assesses symptoms of anxiety and/or 10 points or more on the Patient Health Questionnaire-9 (PHQ-9) that assesses symptoms of depression	Students with an increased risk of suicide detected by the Patient Health Questionnaire-9 (PHQ-9), and these students will be referred to the university&apos;s customer service; students with cognitive and/or physical (motor, visual and auditory) limitations that make it impossible to perform yoga practices	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-5bzyrnq	Efficacy of Ozone therapy in patients with Endometriosis	Recruiting	Intervention	2023-08-10	<NULL>	<NULL>	6332	Efficacy of Ozone therapy on the signs and symptoms of Endometriosis: a controlled and randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-17	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-5bzyrnq	<NULL>	The inclusion criteria adopted will be: Women with Endometriosis with laboratory diagnosis obtained through at least one of the following exams: specialized ultrasound with bowel preparation, pelvic magnetic resonance, videolaparoscopy and biopsy; age group between 20 and 50 years; absence of climacteric or premature ovarian failure; pelvic pain complaints; ability to respond to questionnaires; consent to participate in the study to sign the informed consent.	Exclusion criteria will be: history of hysterectomy or oophorectomy; pregnant or breastfeeding women; BMI greater than 30 kg/m2 have a history of previous physical abdominal trauma in the last 3 months; use of psychotropic medications; infectious-contagious diseases (tuberculosis, leprosy, HIV, systemic fungal diseases) or any other similar condition; severe underlying disease (heart, kidney, liver, lung) or malignancy; diabetes mellitus and decompensated hyperthyroidism; history of topical and aesthetic treatments in the last 3 months; glucose 6-phosphate deficiency; lack of ability or willingness to provide informed consent; lack of availability for visits or to comply with study procedures; hypersensitivity to ozone therapy treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-4smj974	Adult eating behavior: an intervention based on Mindful Eating and its impact on food and well-being	Recruitment completed	Intervention	2023-08-09	<NULL>	<NULL>	6319	Adult eating behavior: an intervention based on Mindful Eating and its impact on food and well-being variables	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4smj974	<NULL>	Adult men and women aged between 18 and 59; be literate; have access to and mastery of internet use.	Professionals or students in Nutrition or Psychology; have psychiatric disorder in the acute phase; practitioners of mindfulness, meditation, yoga or similar, in the last 6 months (with formal practice at least once a week); pregnant; have cognitive difficulties that do not allow the understanding of the issues of the instruments used in data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-7gbffqc	Does nurse counseling reduce anxiety in women starting assisted reproductive treatments?	Not yet recruiting	Intervention	2023-08-09	<NULL>	<NULL>	6320	Nursing consultation to reduce anxiety in women starting assisted reproductive technology treatments: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7gbffqc	<NULL>	Infertility; IVF/ICSI	Intrauterine insemination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-2qc7q2k	How much the pharmacist helps the multidisciplinary team in the care of post-stroke patients: a cohort study	Recruitment completed	Observational	2023-08-09	<NULL>	<NULL>	6321	The impact of the insertion of the pharmaceutical professional in the multidisciplinary team in the care of post-stroke patients: a cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-2qc7q2k	<NULL>	Adult and elderly patients will be included in the study; of both sexes; who are between the 1st and 30th day of discharge after an ischemic or hemorrhagic stroke; who do not show suggestive cognitive damage on the Mini-Mental State Examination (MMSE); in addition, those who have access to the internet and/or landline	Patients with a clinical diagnosis of a new stroke will be excluded from the study; and those with no telephone contacts.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-6n5wq43	Chemical characterization of grains, flours and sorghum-based products and impact of consumption on human health	Recruitment completed	Intervention	2023-08-09	<NULL>	<NULL>	6322	Chemical characterization and bioactive compounds of grains, flours and products based on new genotypes of sorghum and the impact of consumption on human health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	Departamento de Nutrição e Saúde da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-6n5wq43	<NULL>	male, aged between 18 and 40 years; body mass index (BMI) ≥ 27.0 and ≤ 34.9 kg/m²; waist circumference ≥ 90 cm; fasting capillary blood glucose ≥ 70 and ≤99 mg/dL; capillary cholesterol &lt; 240 mg/dL; capillary triglyceride &lt; 150 mg/dL.	diabetic individuals or individuals with a family history of diabetes or glucose intolerance; patients with chronic and/or acute illnesses; alcoholics and/or smokers; who make regular use of anti-inflammatory drugs, corticoids, antibiotics or that affect appetite and/or energy, lipid and glucose metabolism; who are using a dietary fiber supplement; who had infectious or allergic episodes in the last 3 months; who have an aversion or allergy to sorghum; who are lactose or gluten intolerant; who have undergone a diet for weight loss or have fluctuated in weight greater than ± 5 kg in the last 3 months; that you do not consume the test preparations for more than 6 days (consecutive or not) in each intervention period; and show any adverse effect that prevents you from continuing the study or demonstrate a desire not to continue participating in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-42df927	Intervention for university students with symptoms of Depression and Suicidal Ideation during Covid-19 pandemic	Recruiting	Intervention	2023-08-09	<NULL>	<NULL>	6324	Online Cognitive-Behavioral Therapy Intervention protocol for university students with symptoms of Depression and Suicidal Ideation during the Covid-19 pandemic	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-42df927	<NULL>	Students aged 18 or over; followed courses Physical Education; Physiotherapy; Nutrition; Psychology; Social Work; Occupational Therapy at the Federal University of São Paulo; minimum score of thirteen points on the Depression Anxiety Stress Scale; or risk of suicide; or suicide attempt by the International Neuropsychiatric Mini Interview	Students who do not agree to participate in the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-6g8mjzk	Use of transvaginal non-ablative Radiofrequency in the Treatment of Urinary Incontinence and Vaginal Atrophy	Recruiting	Intervention	2023-08-08	<NULL>	<NULL>	6317	"Transvaginal non-ablative Radiofrequency in the Treatment of Urinary Incontinence and
Genitourinary Syndrome of Menopause: blinded, controlled, randomized clinical trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade de Caxias do Sul - UCS	Universidade de Caxias do Sul - UCS	https://ensaiosclinicos.gov.br/rg/RBR-6g8mjzk	<NULL>	Postmenopausal women, diagnosed with genitourinary syndrome of menopause, urinary incontinence (stress or mixed with predominance of stress)	Expressed desire for surgical treatment for urinary incontinence; identification of the presence of pelvic tumors; grade III and IV pelvic prolapse; previous surgery for urinary incontinence or genital prolapse; neurogenic bladder; cardiac pacemaker carriers; being under physical therapy treatment for urinary incontinence; have a urinary tract infection in a previously performed urine test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-8xvwgf7	Evaluation of pain and the amount of medication used after root canal treatment in molars with and without enlargement of the final root area: a clinical study	Data analysis completed	Intervention	2023-08-08	<NULL>	<NULL>	6318	Evaluation of post-operative pain and analgesic use after Endodontic Treatment in molars with and without forminal enlargment: prospective randomized clinical test	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-15	Fabiana Menezes Galdino de Aragao	Centro de Pesquisas Odontologicas São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-8xvwgf7	<NULL>	Healthy volunteers; both sexes; age above 18 years	Pregnancy; diabetics; immunosuppressed patients; under 18 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-9dkn9ry	Effects of treatment with FOPCON in patients with Fibrodysplasia Ossificans Progressiva	Recruitment completed	Intervention	2023-08-07	<NULL>	<NULL>	6311	Clinical, biochemical and molecular aspects in patients with Fibrodysplasia Ossificans Progressiva before and after treatment with ascorbic acid, propranolol, hesperidine and epigallocatechin	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal de Mato Grosso do Sul	Instituto de Assistência e Pesquisa em Educação e Saúde - IAPES	https://ensaiosclinicos.gov.br/rg/RBR-9dkn9ry	<NULL>	Individuals with clinical signs of classic FOP (and possible variants); both sexes; any age; term of consent/signed assent	Link to other experimental research proposals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-8f8fb4p	Feasibility and effectiveness of a telerehabilitation program for children and adolescents with neuromotor disorders	Recruiting	Intervention	2023-08-07	<NULL>	<NULL>	6312	Online Assessment and Guidance Program for children with Neuromotor Disorders: longitudinal study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-31	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8f8fb4p	<NULL>	Children and adolescents with neuromotor disorders; of both sexes; from five to seventeen years; independent in the use of upper limbs to perform activities of daily living; classify on the Functional Mobility Scale (FMS) equal to or greater than two	Physical disability only; absence of vision or hearing; presence of mental illness; having only learning difficulties or disorders; inability to understand simple commands	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-6brhz73	Effects of Transcranial Electrical Stimulation associated with Electrical Stimulation in the leg on gait recovery in individuals after chronic Stroke: a randomized controlled clinical trial	Data analysis completed	Intervention	2023-08-07	<NULL>	<NULL>	6313	Effects of Transcranial Direct Current Stimulation associated with Peripheral Electrical Stimulation on the functional recovery of individuals after chronic Stroke: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-05	Universidade Federal do Ceará	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6brhz73	<NULL>	Volunteer of both sexes; single case of stroke for at least 6 months; ischemic or hemorrhagic brain injury; age above 18 years; presence of motor sequelae in one hemibody; ability to walk approximately 10 meters on the ground with or without a walking aid; minimum score of 24 points (for individuals with schooling) or 18 points (for individuals with no schooling) on ​​the mini-mental state exam	Epilepsy episodes; undiagnosed headache; intracranial metal implant; cardiac pacemaker; pregnancy (or suspected); depression; other clinical conditions of orthopedic, neurological or cardiac origin that do not allow participation in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:12
RBR-65ycsys	Temperature changes in individuals with knee Osteoarthritis undergoing two different types of Physical Exercise: a randomized controlled clinical trial	Recruiting	Intervention	2023-08-07	<NULL>	<NULL>	6314	Thermographic changes in individuals with knee Osteoarthrits submitted to exercise in Closed and Open Kinetic Chain: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Centro de Ciências da Saúde da Universidade Federal da Paraíba	Centro de Ciências da Saúde da Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-65ycsys	<NULL>	Individuals aged 40 to 80 years; of any gender; diagnosed with knee osteoarthritis, whose clinical stage allows for the implementation of the exercise protocols proposed in this research	Subjects with comorbidities that limit the performance of the proposed exercise; subjects using any resource that alters body thermogenesis within 24 hours of the assessment; subjects engaging in physical activity less than 2 hours prior to the assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-5n8sn7b	Effectiveness of Cupping use on Muscle Pain in recreational amateur Runners: randomized clinical trial	Recruitment completed	Intervention	2023-08-07	<NULL>	<NULL>	6315	Effectiveness of Cupping Therapy on Muscle Pain in recreational Runners: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-5n8sn7b	<NULL>	Ages of 18 and 59; without gender restrictions; who have been running for at least two months and can cover a distance of ten kilometers without interruption.	Self-report musculoskeletal pain at the time of the evaluation; have a difference greater than 1.5 cm in lower limb size will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-7pzb4sw	The effects of flower essence therapies on people with alcohol withdrawal	Not yet recruiting	Intervention	2023-08-07	<NULL>	<NULL>	6316	Efficacy of Bach Flower Remedies in individuals with down Syndrome Alcohol Abstinence: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7pzb4sw	<NULL>	Female and male users, have a diagnosis of disorder related to alcohol abuse, be 18 years old or older, have been admitted to CAPS AD III, have an up-to-date Single Therapeutic Project (PTS), have been previously diagnosed with Down Syndrome Mild/moderate alcohol abstinence and being in overnight care (24-hour monitoring) for the first time.	Users who make use of multiple drugs, who have a previous allergy to any component of the Bach Flower Remedies, who for some reason have evaded the service, or any situation that interrupts continued follow-up (evasion or transfer to another device in the healthcare network). health).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-6vbzs7m	Perform blood test to know the value of fats, glucose and anthropometric measurements in people who do Intermittent Fasting	Recruitment completed	Intervention	2023-08-05	<NULL>	<NULL>	6310	Assessment of lipid profile, glycemic and anthropometric measurements in iIntermittent fasting adherents	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Professor Edson Antônio Vellano	Universidade Professor Edson Antônio Vellano	https://ensaiosclinicos.gov.br/rg/RBR-6vbzs7m	<NULL>	Patients with an overweight body mass index, grade 1 obesity, or grade 2 obesity.	Patients who did not follow the diet correctly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-34m423b	Development of a Mathematical Model to calculate the risk of delirium after Oncological Surgeries	Recruiting	Observational	2023-08-04	<NULL>	<NULL>	6308	Development of a Nomogram to predict the likelihood of postoperative delirium in patients undergoing Oncological Surgery	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Fundação Antônio prudente- Hospital A.C.Camargo cancer Center	Fundação Antônio prudente- Hospital A.C.Camargo cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-34m423b	<NULL>	patients over 18 years old;  scheduled to undergo oncology surgeries.	refusal to participate in the study; patients who have undergone another surgical-anesthetic procedure in the last seven days; patients who need another surgical-anesthetic procedure in the first seven postoperative days; patients with confirmed delirium in the preoperative period; patients with a confirmed diagnosis of dementia; patients undergoing OTI/VM (OroTracheal Intubation / Mechanical Ventilation) in the preoperative period; patients remaining under OTI / VM in the POI (immediate postoperative period) for more than 12 hours; neurological surgeries; emergency surgeries .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-10wz74mt	Evaluation of pain after Endodontic Treatment using different substances	Recruitment completed	Intervention	2023-08-03	<NULL>	<NULL>	8022	Evaluation of pain after Endodontic Treatment using Acid Glycolic or EDTA as final irrigation solution: Prospective double blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-20	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-10wz74mt	<NULL>	Healthy patients; both genders; age between 18 and 80 years; need for endodontic treatment	Allergy to local anesthetics; allergy to corticosteroids and starch; use of analgesic or anti-inflammatory drugs 12 hours before the procedure; pregnant or lactating women; diabetics not under control; teeth with open apex	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-9vgrz75	Body Image Perception Disorder: Assessment Questionnaire for Candidates for Nasal Plastic Surgery	Recruiting	Observational	2023-08-02	<NULL>	<NULL>	6303	Body Dysmorfic Disorder: Assessment Questionnaire for Candidates for Nasal Plastic Surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-12-31	Hospital Paranaense de Otorrinolaringologia IPO	Hospital Paranaense de Otorrinolaringologia IPO	https://ensaiosclinicos.gov.br/rg/RBR-9vgrz75	<NULL>	Patients aged 18 years and over;  of both sexes; candidates for rhinoplasty will be included in the examination.	Patients with previously diagnosed severe behavioral disorders will be excluded from the study; A Free and Informed Consent Form will be applied to all study participants, excluding those who do not agree with the premises of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-49dk634	Effects of Pelvic Floor Training in the preoperative period of Radical Prostatectomy on Urinary Incontinence and Erectile Dysfunction	Not yet recruiting	Intervention	2023-08-02	<NULL>	<NULL>	6304	Effects of a Pelvic Floor Muscle Training Program in the preoperative Radical Prostatectomy on Urinary Incontinence and Erectile Dysfunction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-20	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-49dk634	<NULL>	Men between 55 and 80 years of age; localized prostate cancer	Patients with metastatic cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-8trwmwd	Effects of the amount of muscle mass involved in aerobic exercise on state anxiety level in young women exposed to unpleasant stimuli	Not yet recruiting	Intervention	2023-08-02	<NULL>	<NULL>	6305	Effects of the amount of Muscle Mass involved in Aerobic Exercise on State Anxiety level in young women exposed to Unpleasant Stimuli	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8trwmwd	<NULL>	Women; aged between 18 and 40 years	Are in menstrual period; pregnant; contraindication for performing physical activity (PAR-Q); anxiolytic treatment of any kind; dysfunction (cardiac, endocrine, orthopedic and metabolic) self-reported that may interfere with performance; are not literate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-108rjm34	Intervention with mindfulness therapy in adolescents with use substance disorders	Recruiting	Intervention	2023-08-02	<NULL>	<NULL>	6306	Effect of mindfulness-based relapse prevention intervention on drug use in adolescents with substance use disorder participating in a therapeutic addiction program, Manizales, Colombia: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-14	Ministerio de Ciencia Tecnología e Innovación  MINCIENCIAS	Universidad de Caldas	https://ensaiosclinicos.gov.br/rg/RBR-108rjm34	<NULL>	Time of abstinence greater than 15 days after the detoxification phase, validated by the unit&apos;s treating psychiatrist; Age between 12 and 19 years; Diagnosis of substance use disorder according to the Diagnostic and Statistical Manual of Mental Disorders; Ability to speak and read Spanish; Signed informed consent of parents and assent of patient	Intellectual disability documented by standardized cognitive testing or significant cognitive impairment according to the montreal cognitive assessment; hearing or visual impairments that prevent him/her from completing the instruments and understanding the support material; patients presenting psychosis at the time of evaluation; imminent risk of suicide; high risk of presenting withdrawal syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-92rqy4f	Efficacy of physical therapy in neuropathic pain patients	Recruiting	Intervention	2023-08-02	<NULL>	<NULL>	6307	Efficacy of somatosensory rehabilitation in neuropathic pain patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Estadual do Centro Oeste	Universidade Estadual do Centro Oeste	https://ensaiosclinicos.gov.br/rg/RBR-92rqy4f	<NULL>	Individuals over 18 years old; of both sexes; with a clinical and functional diagnosis of neuropathic pain or peripheral neuropathy	Physiotherapy treatment directed at neuropathy together with the research period; significant cognitive changes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-7k87ynr	Evaluation of the clinical effectiveness of treating moderate and severe periodontitis with S-PRG particle solution: a randomized controlled clinical trial	Recruiting	Intervention	2023-08-02	<NULL>	<NULL>	6524	Clinical efficacy of Full-mouth Scaling associated with S-PRG particles solution for the Non-surgical Treatment of stage III and IV Periodontitis: A randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-04	Instituto de Ciência e Tecnologia de São José Dos Campos ICTSJC -  Universidade Estadual Paulista UNESP	Instituto de Ciência e Tecnologia de São José Dos Campos ICTSJC -  Universidade Estadual Paulista UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7k87ynr	<NULL>	Stage III and IV periodontitis; at least 6 sites with probing depths greater than or equal to 6 mm in at least 2 multirooted teeth or 2 single-radicular teeth in at least one quadrant; radiographic bone loss extending from the middle to the apical third of the roots; at least 18 teeth; over 18 years of age; in good general health; agree to participate in the study by signing a consent form	Smokers; Pregnant or lactating women; Patients who have received periodontal treatment within the past 6 months; Chronic use of drugs that affect the periodontal response such as antibiotics, anti-inflammatory drugs, anticonvulsants, immunosuppressants and sodium channel blockers within 6 months; Systemic diseases such as diabetes, cardiovascular disease, cancer, obesity, rheumatoid arthritis, metabolic syndromes, respiratory diseases or need for antibiotic prophylaxis; Patients who have braces;  History of sensitivity to chlorhexidine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-75mvd9k	Lavender aroma inhalation for pain relief after heart surgery	Recruiting	Intervention	2023-08-01	<NULL>	<NULL>	6299	Effectiveness of aromatherapy with Lavender oil angustifolia in post-operative heart surgery pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-03	Rodrigo Assis Neves Dantas	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-75mvd9k	<NULL>	Mediate postoperative period of cardiac surgery; being hemodynamically stable or compensated by vasoactive drugs; being able to be evaluated using pain scales; do not have a lavender allergy; not having a narcotic addiction; not having a respiratory disease or having had any respiratory complications during the surgery; absence of chronic diseases that cause pain	Intubated patients; dissatisfaction with the continuation of the research; incidence of any clinical or surgical complication requiring urgent medical intervention; presence of any olfactory disorder recorded in the medical record; discomfort while inhaling lavender oil	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-8bmtw44	Assessment of weight and height and enuresis after maxillary expansion in mouth breathing children	Recruiting	Intervention	2023-08-01	<NULL>	<NULL>	6301	Evaluation of masticatory function, morphofunctional changes, guarantee and quality of life related to oral health in mouth breathing children after mouth expansion maxilla  Randomized Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-30	Programa De Pós Graduação da Faculdade de Odontologia da Universidade Federal do Pará	Programa De Pós Graduação da Faculdade de Odontologia da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-8bmtw44	<NULL>	Children from 8 to 12 years old; Mouth breathers  who present unilateral or bilateral posterior crossbite or maxillary atresia requiring maxillary expansion; Have primary enuresis	Children with psychiatric disorders; Carriers of some Syndromes with cleft lip or and lip and palate; Patients with behavioral disorders and who make use of continuous antieuretic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-8hv4fms	Video that helps to reduce the anxiety of patients with HIV/AIDS	Not yet recruiting	Intervention	2023-08-01	<NULL>	<NULL>	6302	Effectiveness of audiovisual resource in the acquisition of knowledge and reduction of the level of anxiety of patients with HIV/Aids: randomized blind trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-10	Daniele Vieira Dantas	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-8hv4fms	<NULL>	age 18 years or older; of both sexes; having been diagnosed with HIV, being admitted to Hospital Giselda Trigueiro with a recent diagnosis of HIV; be hospitalized at Hospital Giselda Trigueiro for at least 24 hours	patients who present: have been diagnosed with AIDS with knowledge of HIV prior to hospitalization; have a reduced level of consciousness or psychomotor agitation; communication difficulty; visual and auditory deficit that impairs your ability to see and hear; be under sedation, physiological or induced coma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-45fpgqh	Effects of Caloric Restriction combined with intermittent fasting on metabolism and body composition of individuals with Severe Obesity - MACRO study	Recruiting	Intervention	2023-08-01	<NULL>	<NULL>	7363	Effects of Caloric Restriction combined with Time Restricted Eating strategy on metabolism and body composition of individuals with Severe Obesity - MACRO study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Instituto de Nutrição - Universidade do Estado do Rio de Janeiro	Instituto de Nutrição - Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-45fpgqh	<NULL>	Adults aged 20 years and over; of both sexes; with a body mass index (BMI) &gt; 40 kg/m2	Individuals who have the following conditions that may interfere with body composition or Basal metabolic rate(BMR); pregnancy; lactation; use of illicit drugs; infectious or oncological diseases; thyroid disorders; heart, kidney, liver, or lung insufficiency; use of medications that alter energy metabolism (corticosteroids, beta-blockers, sulfonylureas, Glucagon-like Peptide-1 (GLP1) agonists, dipeptidil peptidase 4 (DPP4)  inhibitors, and Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors); use of medications for obesity treatment (serotonergic, noradrenergic, and inhibitors of intestinal lipid absorption); individuals who have undergone calorie restriction (CR); have experienced a body mass modification &gt;10% in the last six months; have undergone bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-6m9pwb7	Efficacy of behavioral change on cardiovascular system, physical activity level and functionality after exacerbation of Chronic Obstructive Pulmonary Disease	Recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6289	Efficacy of an early behavioral behavioral strategy after acute exacerbation of Lung Disease on cardiovascular profile, physical activity level, and functioning: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-21	Universidade Federal de São Carlos	Santa Casa de Misericórdia de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-6m9pwb7	<NULL>	Patients of both genders will be included in the study; diagnosed with Chronic Obstructive Pulmonary Disease according to the classification of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) system (forced expiratory volume in 1 second/forced vital capacity less than 70% post-bronchodilator; stage 2 (less than or equal to 50% of forced expiratory volume in 1 second and less than 80% of predicted); stage 3 (less than or equal to 50% of forced expiratory volume in 1 second and less than 30% of predicted); aged 40 to 80 years; that the cause of hospitalization is the exacerbation of Chronic Obstructive Pulmonary Disease, who are breathing spontaneously and clinically stable before hospital discharge	Patients with cognitive impairment (Mini Mental &lt;20); have unstable heart disease; neurological disease; walking difficulties; persistent arrhythmias; acute myocardial infarction (&lt;6 months); stroke; neoplasm undergoing chemotherapy; patients who have another associated lung disease or musculoskeletal disease that compromises mobility; systemic arterial hypertension or uncontrolled diabetes mellitus; who had participated in a pulmonary rehabilitation program 3 months before the exacerbation; patients with moderate and high risk of falling (Morse fall scale ≤24 points); pregnant or puerperal women and patients who do not have access to a cell or landline telephone. During the follow-up period, those patients who are hospitalized during the collection period will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-662jnyh	Comparison of respiratory and arm muscle strength training on breathing in patients with Parkinsons Disease	Recruitment completed	Intervention	2023-07-31	<NULL>	<NULL>	6290	Comparison between respiratory and upper limb peripheral resistance training on respiratory function in patients with Parkinson&apos;s Disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Instituto de Ciências da Saúde - Universidade Federal da Bahia	Instituto de Ciências da Saúde - Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-662jnyh	<NULL>	Being on regular medication for Parkinson&apos;s Disease; be in “on” period; be aged 50 years or older; present stage 2, 2.5 or 3 according to the modified Hoehn and Yahr Classification.	Present neurodegenerative diseases excluding Parkinson&apos;s disease, dementia, musculoskeletal diseases that make it impossible to practice physical activity; uncontrolled chronic diseases (hypertension, diabetes mellitus, chronic pain); unstable cardiovascular diseases (acute heart failure; recent myocardial infarction; unstable angina and uncontrolled arrhythmias); use of alcohol and other toxic substances; practicing or having practiced a physical exercise program in the last 6 months; or if you participate or have participated in regular resistance training (eg 2-3 times a week) in the previous 12 months; more than 4 absences during the intervention protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-8pd94mw	Acceptance and Commitment Therapy associated with Exposure in OCD: Online Group Experiment	Recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6291	Acceptance and Commitment Therapy associated with Exposure and Prevention Response in Obsessive-Compulsive disorder: An open online group trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro -IPUB	Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro -IPUB	https://ensaiosclinicos.gov.br/rg/RBR-8pd94mw	<NULL>	Current diagnosis of Obsessive-Compulsive Disorder (OCD); The OCD must be the most severe disorder; Be in regular treatment with a psychiatrist at the clinic and on stabilized medication for at least one month and willing to remain on a fixed dose during study participation (unless advised by a physician of necessary change); 18 years old; Ability to read and complete questionnaires; Minimum score of 4 on the Clinical Global Impression (CGI).	Presence of psychotic disorders, bipolar disorder, mental retardation, recent history of alcohol or other substance abuse or dependence, severe personality disorder (as assessed by the attending physician); Severe organic medical disorder; Significant current or recent suicide risk; Any concomitant psychotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-8mxj56m	Capacitar, World Health Organization caregivers training program for parents of children with autism in Brazil	Recruitment completed	Intervention	2023-07-31	<NULL>	<NULL>	6292	Capacitar world health organization caregivers skills training program for parents and caregivers of children with developmental disorders	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Universidade Federal do Paraná	Secretaria Municipal de Saúde de Curitiba	https://ensaiosclinicos.gov.br/rg/RBR-8mxj56m	<NULL>	Caregivers of children between 2 and 9 years old, diagnosed with neurodevelopmental disorder or autism, who had been referred for treatment at a specialized municipal outpatient clinic and whose caregiver had time to participate in the intervention for 9 weeks	Those who did not show interest in participating in the program, who did not feel comfortable to carry out the training in the online modality in the second stage of the intervention, or who did not have access to the internet. Excluded those who did not remain after session 1.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-10n3h7vz	TENS modalities in the relief of menstrual cramps in young women	Recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6293	High and low frequency TENS in young people with primary dysmenorrhea: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-10	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10n3h7vz	<NULL>	Young women; age between 15 and 29 years; nulliparous; regular menstrual cycle; self-report and presence of PD (pelvic or lower abdominal pain, occurring from 48 hours before the start of the menstrual period to 72 hours after the first day of menstruation); and with pain intensity greater than or equal to three points on the Numerical Rating Scale (NRS) during their participation	Pregnant women or mothers who are breastfeeding; use of any type of intrauterine device; skin lesions in the area where the electrodes will be placed; self-reported neurological or cardiac diseases; diagnosis of gynecological disorders (endometriosis, adenomyosis, uterine fibroids, etc.), which may be associated with secondary dysmenorrhea	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-4ccdqh6	Clinical study of Removable Partial Dentures constructed with different structural materials	Recruitment completed	Intervention	2023-07-31	<NULL>	<NULL>	6294	Removable Partial Dentures with Co-Cr versus PEEK structure: clinical crossover study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Faculdade de Odontologia de Piracicaba - FOP/UNICAMP	Universidade Estadual de Campinas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-4ccdqh6	<NULL>	Present good general health status or presence of systemic diseases (such as hypertension and/or diabetes) that are properly controlled; age between 40-65 years; total upper and lower partial edentulousness (Kennedy Class I), with unsatisfactory CDs and RPDs according to Vigild&apos;s criteria (Vigild et al., 1987); having the shape of the lower alveolar ridges classified as horizontal or distal ascending (in the mesiodistal direction), and normal or high (in the buccolingual direction), according to the American College of Prosthodontics (McGarry et al. 1999), evaluated by means of the clinical examination and normal salivary flow (≥ 0.6 ml/min)	Individuals with painful symptomatology of the temporomandibular joints and/or mastication muscles; uncontrolled systemics diseases; xerostomia patients; severe periodontal disease and/or tooth mobility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-84nmnm9	Evaluation of the use of PET/CT in Adenoid Cystic Carcinoma (ADC)	Recruiting	Observational	2023-07-31	<NULL>	<NULL>	6295	Evaluation of the use of PET/CT with 18F-PSMA as a staging tool and potential predictor for theranostic therapy in patients diagnosed with Adenoid Cystic Carcinoma	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-01	Eduardo Nóbrega Pereira Lima	Fundação Antônio Prudente - AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-84nmnm9	<NULL>	Age above 18 years. Histological diagnostic confirmation of Neoplasia Adenoid Cystic Carcinoma (ADC). Ability to understand aspects associated with the proposed clinical study and consent to participate.Patients who have performed at least one onventional imaging (computed tomography, magnetic resonance imaging, ultrasonography, and bone scintigraphy) as part of an initial assessment of the extent of neoplastic disease or as part of a recent assessment of ongoing tumor response to CAdC neoplasia.	Clinical condition that contraindicates the use of targeted imaging for staging conventional or exposure to radiopharmaceuticals such as: ongoing pregnancy, breastfeeding or any condition that the attending physician considers a risk for participation in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-5hgcgy4	Effect of Laser on Postoperative Pain and Quality of Life after Root Canal Treatment in patients with Apical Periodontitis	Recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6296	Effect of Photobiomodulation on Postoperative Pain and Quality of Life after Endodontic Treatment in patients with Apical Periodontitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-06	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5hgcgy4	<NULL>	Be over 18 years of age; both genders; having at least one tooth diagnosed with pulp necrosis and apical periodontitis, with no indication for surgical endodontic treatment; agree to participate in the research by signing the Free and Informed Consent Form (Annex 1)	Pregnant women; have severe health impairments that possibly have a negative impact on quality of life (neoplasms malignancies, severe heart disease, immunosuppression); be making continuous use of analgesic and/or anti-inflammatory drugs at the time of treatment endodontic; having hypersensitivity to non-steroidal anti-inflammatory drugs; present endodontic complications such as calcifications, resorption internal/external, dental perforations, longitudinal/vertical fractures, disease advanced periodontal or severe occlusal problems; have teeth with apical periodontitis in an element already endodontically treated (retreatments)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-294pmdq	The effect of Activities in Contact with Nature on adults&apos; Depressive Symptoms	Not yet recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6297	Activities in Contact with Nature and Symptoms of Depression in adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Estadual de Santa Cruz	Universidade Estadual de Santa Cruz	https://ensaiosclinicos.gov.br/rg/RBR-294pmdq	<NULL>	Be 18 years of age or older. Both genders. Be able to answer the survey questionnaire. Attend weekly spaces at the State University of Santa Cruz. Have time availability to participate in the activities that will be promoted	Participants who have medical restrictions to carrying out the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-9fvwk4m	Effect of green propolis on periodontal treatment of type 2 diabetics	Recruiting	Intervention	2023-07-31	<NULL>	<NULL>	6298	Effect of green propolis supplementation on non-surgical periodontal treatment of individuals with type 2 diabetes: randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-03-09	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9fvwk4m	<NULL>	Participants with type 2 diabetes mellitus and periodontitis stages II and III, with a minimum age of 30 years and at least fourteen teeth present in the oral cavity, and who agree to participate in the research through an informed consent form will be included.	The following individuals will be excluded from the study: with a history of allergy to pollen or any product of apiarian origin; carriers of diseases with changes in the immune system; smokers; pregnant and lactating women; who have undergone periodontal treatment in the last 6 months; who have undergone antimicrobial and anti-inflammatory therapy in the last 3 months; who use anticoagulant and platelet antiaggregant; with dental implants; with glycated hemoglobin greater than or equal to 9% and/or fasting glucose greater than or equal to 250mg/dl; who change their diabetes medication during the study period; under 30 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-534ppvp	Effects of one-year treatment of Equine-Assisted Therapy in children with Cerebral Palsy	Recruitment completed	Intervention	2023-07-31	<NULL>	<NULL>	6579	Influence of hippotherapy on postural balance, gait and functional performance in children with cerebral palsy.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-23	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-534ppvp	<NULL>	"Having a medical diagnosis of Cerebral Palsy with an indication for the practice of hippotherapy through an appropriate assessment. Have from 2 to 14 years old. Possess cognitive ability to respond satisfactorily to the commands requested so that they are able to participate in data collection. Remain in the bipedal orthostatic position without using shoes or orthotics for 20 seconds. Have independent gait without and with the use of devices due to the data collection procedure.
Have hip abduction of at least 20 degrees to remain seated on the horse. Children could undergo conventional physical therapy in addition to Riding Therapy."	Do not meet the requirements of the inclusion criteria. Have undergone a surgical procedure in the last 12 months or are planning a surgery for the research period. Have performed neuromuscular chemical block for less than 6 months or are planning to perform it during the research period. Have uncorrected visual or hearing deficits. Having uncontrolled seizures, hip dislocation, excessive contracture of adductors and severe osteoporosis or any other reason that prevents you from riding a horse, such as excessive fear. If they do not have at least 75% attendance at hippotherapy sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-7csg79n	Photobiomodulation in Pulmonary Fibrosis post Covid-19	Recruiting	Intervention	2023-07-30	<NULL>	<NULL>	6286	Photobiomodulation in the treatment of Pulmonary Fibrosis post Covid-19	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Centro Universitário de Itajubá	Clínica Escola de Fisioterapia no Centro Universitário de Itajubá - FEPI	https://ensaiosclinicos.gov.br/rg/RBR-7csg79n	<NULL>	Patients with post-COVID-19 pulmonary fibrosis; aged between 51 and 81 years; both genders	Patients with thromboembolic alterations such as Deep Vein Thrombosis (DVT) and Pulmonary Embolism; tracheostomized; with a body mass index (BMI) &gt;29.9 kgm2; who had neoplasms; history of photosensitivity; who had previously undergone Cardiopulmonary rehabilitation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-3kh3y2s	Dysbiosis in the oral cavity of patients undergoing invasive mechanical ventilation and receiving oral care, combined with antimicrobial photodynamic therapy.	Recruiting	Intervention	2023-07-30	<NULL>	<NULL>	6287	Dysbiosis in the oral cavity and its relationship with the complications of patients on invasive mechanical ventilation and under oral care, associated or not with antimicrobial photodynamic therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-15	Faculdade de Odontologia da Universidade de São Paulo	Associação Hospitalar Lenoir Vargas Ferreira	https://ensaiosclinicos.gov.br/rg/RBR-3kh3y2s	<NULL>	Critically ill patients admitted to the Intensive Care Unit; undergoing mechanical ventilation; intubated within 24 hours; and aged 18 years or older; both genders	Pregnant patients; edentulous patients; patients with severe traumatic brain injury; postoperative patients expected to be discharged within the first 24 hours; patients diagnosed with COVID; patients intubated for more than 24 hours; patients for whom sample collection is not possible; and patients whose legal representative does not sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-5v3sspr	Atherothrombotic aspects of cerebrovascular disease	Recruitment completed	Observational	2023-07-30	<NULL>	<NULL>	6288	Atherothrombotic profile of cerebrovascular disease: prospective cohort	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-01-31	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5v3sspr	<NULL>	Volunteers with asymptomatic or symptomatic extracranial carotid stenosis, both genders, minimum age of 18 years.	Restenosis after previous treatment of carotid endarterectomy or carotid angioplasty in the artery of interest; Inability to sign an informed consent form; Life expectancy less than 6 months; Advanced dementia; Severe kidney failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-86m8dm9	Evaluation of pain and inflammation of the PENG block associated with the femoral lateral cutaneous nerve block in hip prosthesis surgeries	Recruitment completed	Intervention	2023-07-29	<NULL>	<NULL>	6284	Evaluation of the analgesia and inflammatory response of the PENG block associated with the femoral lateral cutaneous nerve block in primary total hip arthroplasty: Clinical, controlled, randomized and blinded trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-24	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	https://ensaiosclinicos.gov.br/rg/RBR-86m8dm9	<NULL>	Patients for elective primary total hip arthroplasty due to coxarthrosis; both genders; age ≥ 18 years; classified by the American Society of Anesthesiologists (ASA) as physical status I or II.	Allergy to local anesthetics; regular use of opioids; diabetes; inflammatory diseases (rheumatoid arthritis, gout, and ankylosing spondylitis); grade II or III obesity (BMI &gt; 35); pregnant women; and patients who received blood transfusion preoperatively, intraoperatively and/or in the first 48 hours postoperatively.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-54pdj93	Volumetric Analysis of a collagen graft versus a graft of patient&apos;s gum for the treatment of implant defects in esthetic region: Controlled clinical trial	Recruiting	Intervention	2023-07-29	<NULL>	<NULL>	6285	Volumetric analysis of a volume-stable collagen matrix versus autogenous connective tissue graft in the treatment of implant deficiencies in the esthetic zone: Randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-54pdj93	<NULL>	&gt; 18 years. Presence of at least one adjacent tooth at the surgical site. Adequate oral hygiene (Bleeding on probing &lt;20%; Plaque index &lt;20%). Healthy. Signed Informed Consent Form.	Pregnant or lactating women. History of malignancy, radiotherapy or chemotherapy for malignancy in the past 5 years. Smokers (&gt;10 cigarettes/day).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-268ms5y	Comparison of two different minimally invasive surgical techniques in primary open angle glaucoma	Recruiting	Intervention	2023-07-29	<NULL>	<NULL>	6952	Comparison of Bent ab interno needle goniotomy (BANG) and Gonioscopy-assisted transluminal trabeculotomy (GATT) in primary open angle glaucoma: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	Hospital de Clínicas da Universidade Estadual de Campinas (HC-Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-268ms5y	<NULL>	Primary open angle glaucoma, defined by an open angle on gonioscopy evaluation, visual field loss and RNFL damage on OCT; age between 18 and 80 years; visual field mean deviation (MD) &gt; -12dB; RNFLT&gt;60μm on OCT; prior phacoemulsification with IOL implant; best corrected visual acuity  ≥0,1 on Snellen chart; IOP≥18mmHg with 3 IOP-lowering drops, and between 20mmHg and 36mmHg after medication wash-out	Other types of open angle glaucoma: steroid-induced, pseudoexfoliation, pigmentary e juvenile; congenital glaucoma; angle-clousure; prior cataract surgery less than 30 days; drainage device implant or cyclophotocoagulation; prior vitreoretinal surgery; cornea opacity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:02
RBR-8wqqmk8	Comparison of clinical simulation and deliberate practice in rapid cycles for clinical competence development: a randomized clinical trial	Data analysis completed	Intervention	2023-07-28	<NULL>	<NULL>	6281	Evaluation of clinical simulation and deliberate practice in rapid cycles for the development of clinical competence: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8wqqmk8	<NULL>	The student must be enrolled in the fourth year of nursing at the Federal University of São Paulo; have participated in the lecture dialogued in the remote modality on Nursing Assistance to the patient with Cerebral Vascular Accident in the Emergency Service lasting 40 minutes; both genders	Graduates not enrolled in the fourth year of nursing at the Federal University of São Paulo; those who do not participate in the lecture dialogued in the remote modality on Nursing care for patients with stroke in the Emergency Service lasting 40 minutes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-5wy4vhx	Randomized clinical trial: how a plant called Eclipta prostrata (commonly known as false daisy) can help people with Obesity	Not yet recruiting	Intervention	2023-07-28	<NULL>	<NULL>	6282	Randomized clinical trial: effect of the herbal medicine from Eclipta prostrata (L.) L. (Asteraceae) on phase angle in adults with grade I Obesity	<NULL>	2, randomized-controlled, triple-blind	2	<NULL>	<NULL>	<NULL>	2023-10-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5wy4vhx	<NULL>	Adults of both genders; aged 18 to 59; with grade I obesity; monitored in primary healthcare unities	Participants with comorbidities characterized by low-grade chronic inflammation, except for those associated with obesity and metabolic syndrome; history of chronic use of corticosteroids, immunosuppressants, or nonsteroidal anti-inflammatory drugs; health conditions that may interfere with the parameters measured by bioelectrical impedance analysis, such as edema, chronic kidney disease, end-stage organ failure, or amputated limbs; implanted cardiac devices; chronic diarrhea; ethical restrictions that prevent proper consent for study participation; women who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-6kw6qnx	The effect of an application for cell phones and tablets on medication adherence of elderly people with Systemic Arterial Hypertension	Not yet recruiting	Intervention	2023-07-27	<NULL>	<NULL>	6279	Therapeutic adherence of elderly patients with arterial hypertension: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-15	Universidade de Brasília	Secretaria de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-6kw6qnx	<NULL>	Elderly aged 65 years or older, with stage 1 or 2 SAH; with uncontrolled blood pressure in at least 2 consultations; who use at least 1 daily medication for at least 1 year; who has a cell phone with memory space and internet access; elderly people classified in Profile 1 and 2 of functionality for care purposes, in the Line of Care for Comprehensive Health Care for the Elderly; not practicing physical activity or showing insufficient physical activity, assessed using the short version of the International Physical Activity Questionnaire (IPAQ).	Illiterate elderly will be excluded; who have some physical or intellectual impediment that prevents them from using the application or mobile device; patients with Chronic Kidney Disease and who have a self-reported medical diagnosis of dementia, delirium, psychotic or substance-related mental disorders according to DSM-5 criteria and those who do not complete the research steps; elderly people who present cognitive impairments evaluated through the 10-CD Cognitive Test in which the cutoff scores used for exclusion will be: 17 for the illiterate; 22 for seniors with between 1 and 4 years of schooling; 24 for those with between 5 and 8 years of schooling and 26 for those with 9 or more years of schooling; elderly people with mobility deficits using the Timed Up-and-Go (TUG) scale over 20 seconds, a timed test that assesses gait speed, balance and risk of falling; seniors participating in another clinical trial; research study or exercise program where they perform similar balance and strength activities; and those who have mobility limitations or use walking devices; diagnosis of progressive neurological disease or other acute or unstable medical condition that precludes performance of the exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-2xg3qct	Evaluation of Pain Reduction after surgery in patients undergoing Video Surgery for Gallbladder Removal under General Anesthesia with Initiation of Anesthesia using Sufentanil or Fentanyl, comparative, prospective, randomized clinical study	Recruiting	Intervention	2023-07-27	<NULL>	<NULL>	6475	Evaluation of Postoperative Analgesia in patients undergoing Laparoscopic Cholecystectomy under General Anesthesia with Anesthetic Induction performed using Sufentanil or Fentanyl, comparative, prospective and randomized clinical study	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2022-03-16	Hospital Universitário da Universidade Federal de Sergipe (UFS)	Vila Velha Hospital	https://ensaiosclinicos.gov.br/rg/RBR-2xg3qct	<NULL>	Patients physical status ASA 1, 2 and 3; from 18 years to 85 years; undergoing laparoscopic cholecystectomy under general anesthesia	ASA 4 patients; patients undergoing another associated anesthetic technique such as spinal or epidural anesthesia; surgeries that require other surgical procedures in addition to videolaparoscopy cholecystectomy; cholecystectomy surgeries that require conversion to conventional open surgery; patients with a history of allergic reactions to the use of any of the medications present in the protocol of this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:44
RBR-6p8pkvq	Diagnostic exam for renal cancer	Recruiting	Observational	2023-07-26	<NULL>	<NULL>	6275	Prospective evaluation of the use of PET/CT with 18 F-PSMA in kidney cancer	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-01	Fundação Antônio Prudente - AC Camargo Cancer Center	Fundação Antônio Prudente - AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-6p8pkvq	<NULL>	Patients aged at least 18 years; both genders; with histopathological diagnosis of renal cancer, clear cell or papillary subtypes	None	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-5gbhw5w	Effects and Implementation of the ACT Program in Ceará	Recruitment completed	Intervention	2023-07-26	<NULL>	<NULL>	6277	Intervention program based on scientific evidence with a focus on positive parenting and prevention of violence against children: implementation, development, and research	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-26	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Instituto para a Valorização da Educação e da Pesquisa no Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5gbhw5w	<NULL>	Parents or main caregivers with parental role of 0-to-6-years old children	Participants with impaired understanding of the assessment instructions, which makes data collection unfeasible; parents or main caregivers with children upper than 6 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-6thqfvd	Effect of exercise on signs and symptoms of patients with arm swelling after breast cancer	Recruiting	Intervention	2023-07-26	<NULL>	<NULL>	6278	Effects of resistance and active Kinesiotherapy on signs and symptoms of Lymphedema in patients with Breast Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-6thqfvd	<NULL>	Women over 18 years old; who were diagnosed with breast cancer; underwent surgery with axillary dissection; upper limb lymphedema	Mastectomy with bilateral dissection; metastases diagnosed and described in the medical record; angina, diagnosed heart or kidney pathology; previous dysfunction of circulatory or musculoskeletal upper limbs; patients without cognitive conditions to understand the proposed exercises; pregnant women; diagnosed with rheumatological, autoimmune pathologies; with skin lesions that make lymphatic drainage and functional compressive bandaging unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-9jkkvbb	Effect of purple grape juice on performance and muscle recovery in male runners	Data analysis completed	Intervention	2023-07-26	<NULL>	<NULL>	7409	Effect of purple grape juice (Vitis labrusca) consumption on parameters related to sports performance and exercise-induced muscle damage in runners	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9jkkvbb	<NULL>	Male; age between 18 and 45 years; trained runners with a history of participating in competitions at least once a year; run at least 5 hours a week	Smokers; carriers of any diseases, infectious or inflammatory processes; history of recent musculoskeletal injuries; users (the last 30 days will be considered) of vitamin supplements, minerals, ergogenic aids (such as carnitine, arginine, citrulline, taurine, creatine and caffeine, nitrate, beta-alanine and sodium bicarbonate) or chronic use medications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:20
RBR-7437tk4	Flourishing program for crack/cocaine addicts	Terminated	Intervention	2023-07-26	<NULL>	<NULL>	7651	Implementation of an intervention based on positive psychology: program flourishing as a complementary therapy in the treatment of inpatients addicted to chemical dependency	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-29	Faculdade de Medicina da Universidade de São Paulo - FMUSP	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7437tk4	<NULL>	Adult patients over 18 years old; who have a diagnosis of Crack/Cocaine addiction primarily	Individuals who do not present judgment of reality; restrictions in expression and communication; or who do not have a complete fundamental course of scholarly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-102g28dh	Effect of Lavander essential oil on Pain control, Anxiety and Surgical Discomfort in pacients submitted to third molar extraction (wisdom teeth)	Recruiting	Intervention	2023-07-26	<NULL>	<NULL>	8212	Effect of Lavander essential oil on Pain control, Anxiety and Surgical Discomfort in pacients submitted to third molar extraction. A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-30	Universidade Federal do Paraná - UFPR	Universidade Federal do Paraná - UFPR	https://ensaiosclinicos.gov.br/rg/RBR-102g28dh	<NULL>	This study may include adults over 18 years of age of both sexes who require third molar extraction	Patients under 18 years of age, with a history of using pain or anxiety medications in the 15 days prior to the study, with a history of hypersensitivity to medications, substances or materials used in this experiment, pregnant or lactating women. Patients with general health problems will not be eligible for participation in the study, as well as immunosuppressed patients, people who use anticoagulant or antiplatelet therapy, HIV patients, diabetes mellitus, and patients who are undergoing chemotherapy, as these conditions may interfere with the study results.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:48
RBR-6cghbsd	Probiotics in the Treatment of Gum Disease	Recruiting	Intervention	2023-07-25	<NULL>	<NULL>	6268	Probioticinfluence in the Treatment of Periodontal Disease in Medically Compromised patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Estadual de Ponta Grossa	Curso de Odontologia - Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6cghbsd	<NULL>	The inclusion criteria for the study will be patients with mild to severe periodontal disease. Over 18 years of age. Under medical follow-up due to chronic diseases. The criteria for classifying the patient&apos;s condition as periodontal disease are based on attachment loss, probing depth, and pattern of bone loss. Stage I has interproximal attachment loss of 1-2 mm and probing depths of up to 4 mm. Stage II has interproximal attachment loss of 3-4 mm and probing depths of up to 5 mm. Stage III and IV have interproximal attachment loss of 5 mm or more, with bone loss and tooth loss	Not eligible for the study: Patients undergoing periodontal or orthodontic maintenance. Pregnant or lactating women. Patients with uncontrolled severe systemic disease. Psychiatric problems. Local pathological alterations. Volunteers requiring tooth extraction. Need for antibiotic prophylaxis. Patients who have used analgesic and anti-inflammatory drugs up to 12 hours before treatment. Alcoholism. Smokers. Dentin hypersensitivity or other pulpal pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-6z8tp94	Use of aromas in lower third molar removal surgery	Recruiting	Intervention	2023-07-25	<NULL>	<NULL>	6269	Use of aromatherapy in lower third molar removal surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Centro Universitário Christus - UNICHRISTUS	Centro Universitário Christus - UNICHRISTUS	https://ensaiosclinicos.gov.br/rg/RBR-6z8tp94	<NULL>	Healthy individuals (American Society of Anesthesiologists - ASA I) of both genders; aged 18-35 years; who are required to remove the lower third molars; will be invited to participate in this study. In addition, the following inclusion criteria will also be adopted: (1) third unerupted mandibular molars; (2) third molars that present, in panoramic radiography, similar patterns of root formation, position and degree of impaction when comparing the right and left sides of each volunteer.	Volunteers who met at least one of the following criteria will be excluded: smokers; pregnant or lactating women; patients with orthodontic bands on mandibular second molars; signs of any preoperative inflammatory or infectious condition; systemic diseases; neurological disorders; patients without hearing or with auricular disorders related to the interpretation of sounds (sound frequencies), which may influence the outcomes of the present study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-7ntftdv	Glycemic index and anti-inflammatory effect of cowpea	Recruitment completed	Intervention	2023-07-25	<NULL>	<NULL>	6271	Glycemic index and anti-inflammatory effect of cowpea (Vigna unguiculata L. Walp)	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-15	Coordenação Administrativa do Sul do Espírito Santo - CASES	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-7ntftdv	<NULL>	Eutrophic individuals (body mass index ranging from 18.5 to 24.9 kg/m² and fat percentage from 12 to 20% for males and from 20 to 30% for females); non-smokers; non-pregnant or/lactating women (in the case of women); and who have fasting blood glucose ranging from 70 to 99 mg/dL; maximum age 40 years	Individuals with type 1 or 2 diabetes; first-degree family history of diabetes mellitus; recent digestive, liver, kidney, cardiovascular, thyroid, or inflammatory disease; alcohol intake greater than 2 drinks (&gt; 20 mL) per day; weight instability (± 3 kg in the last 3 months); using drugs that affect metabolism; who have an allergy or aversion to the foods tested	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-5996nhj	The efficacy and safety of Cannabis Extract in muscle pain control	Not yet recruiting	Intervention	2023-07-25	<NULL>	<NULL>	6272	"Evaluation of the efficacy and safety of Full Spectrum Cannabis Extract, in pain control, in patients with Muscular Temporomandibular Disorder
Clinical, randomized, double-blind, placebo-controlled trial"	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2024-01-01	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista Júlio de Mesquita Filho	Sociedade Brasileira de Estudo de Cannabis Sativa	https://ensaiosclinicos.gov.br/rg/RBR-5996nhj	<NULL>	Patients at least 18 years old; both genders; able to understand the questions applied in the tests selected for the research; totally or partially dentate patients with a maximum absence of two (2) teeth per hemi-arch or rehabilitated by fixed prosthesis; patients with presence of Temporomandibular Muscle Dysfunction - TMD according to Axis I (CD/TMD) (Schiffman et al., 2014), whose main complaint of muscle pain is for a period longer than 3 months; patients who sign the Informed Consent Form	Patients with serious diseases, trigeminal neuralgia, tumors, neurological diseases, and psychological problems; patients with total prosthesis; people diagnosed with dental malocclusions and/or presenting with a difference between the central and maximum intercuspation ratio greater than 5 mm, overjet and overbite greater than 6 mm, and anterior or unilateral crossbite; people who have had previous history of Temporomandibular Joint - TMJ surgery, degenerative diseases and neuropathic pain; pregnancy; presence of primary headaches; people allergic to the formulation of the substance used in the study; patients with a history of psychiatric disorders, such as schizophrenia, or a family patients with a history of psychiatric disorders such as schizophrenia or a family history of this disorder; patients taking (or who have taken in the last 3 months before the beginning of the study) of any cannabis product (Liability Waiver present in Appendix 3); patients whose work requires toxicological tests, such as drivers and machine operators, competitive athletes in activities and members of the armed forces, since the substance can lead to labor losses by prohibition of these entities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-2hbf2mx	Evaluation of the solvent Evaporation Time of universal adhesives in the quality of Cervical Lesions restorations	Recruitment completed	Intervention	2023-07-24	<NULL>	<NULL>	6261	Clinical evaluation of the effect of the Prolonged Evaporation Time of the solvent of two universal adhesives in restorations of non-carious Cervical Lesions: double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-15	Universidad de los Andes, Chile	Universidad de los Andes, Chile	https://ensaiosclinicos.gov.br/rg/RBR-2hbf2mx	<NULL>	Patients older than 18 years will be included; Presence of at least two Non-Carious Cervical Lesions per patient regardless of their location in the dental arch; With a need for restorative treatment; acceptable level of oral hygiene according to the Simplified Oral Hygiene Index; Absence of driving difficulties that prevent adequate oral hygiene; Absence of periodontal disease active caries lesions and parafunctional habits; At least 20 teeth in function; Absence of active staples of removable partial dentures on the teeth included in the research and that these are not pillars of prostheses; Non-Carious Cervical Lesions with a maximum of 50% of enamel margin.	Under 18 years old; Patients who do not agree with the terms of the study; Who do not feel motivated to participate in research and maintain oral hygiene; Who have difficulty attending the subsequent controls of the restoration.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-38w7ps7	Exercises of the Pilates Method in abdominal activation and relief of low back pain during pregnancy	Recruitment completed	Intervention	2023-07-24	<NULL>	<NULL>	6262	Effect of an exercise protocol of the Method Pilates in the interrectus abdominis distance,complaint of low back pain and discomfort of the pelvic floor in the gestational period:Randomized Clinical Trial Controlled	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Uberlândia -  Faculdade de Educação Física e Fisioterapia (FAEFI)	Universidade Federal de Uberlândia -  Faculdade de Educação Física e Fisioterapia (FAEFI)	https://ensaiosclinicos.gov.br/rg/RBR-38w7ps7	<NULL>	Pregnant women aged between 18 and 40 years; primigravidae or with previous pregnancies ended before the 21st gestational week; single pregnancy; gestational age of 17 weeks; not having performed previous abdominal surgery; presentation of a certificate from the doctor, responsible for prenatal care, of release for the practice of physical exercises.	Pregnant women with high gestational risk; presence of bone deformities; presence of important muscular dysfunctions; presence of neurological and/or cognitive impairments that prevent the understanding of the proposed procedures; being visibly under the influence of drugs or alcohol; missing two consecutive intervention sessions; termination of pregnancy before the last evaluation; or any alteration of the pregnant woman&apos;s initial condition, which causes her to fit into any of the exclusion criteria, during the intervention, will cause her to be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-2gdd984	Effect of the use of two different types of dental motors on the perception of pain, swelling and difficulty opening the mouth postoperatively in Dental Extractions of lower wisdom teeth: a double-blind randomized clinical trial in a split-mouth	Not yet recruiting	Intervention	2023-07-24	<NULL>	<NULL>	6263	Effect of using a 1:3 multiplier surgical contra-angle versus high-speed pen on the perception of postoperative pain, edema and trismus in mandibular third molar Extraction: a double-blind randomized clinical trial in a split mouth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-25	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-2gdd984	<NULL>	Will be included in the study, 24 patients aged between 18 and 30 years and without impairment of general health according to medical history (healthy) and physical examination, who agree to participate in the study. Through clinical and radiographic examination, patients with indication for bilateral extraction of mandibular third molars, asymptomatic and in class IIB position, according to the Pell &amp; Gregory classification, will be selected.	Exclusion criteria will be considered: (I) history of use of any type of analgesic, anti-inflammatory and antibiotic medication in the 15 days prior to the beginning of the surgical procedure; (II) history of hypersensitivity to drugs, substances or materials used in this experiment; (III) pregnancy or lactation; (IV) pericoronitis or other local infection within 15 days prior to the surgical procedure; (V) and people with a history of acute or chronic systemic disease, such as hypertension or diabetes, for example.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-3bbwwjz	Clinical performance of two glass ionomer cements used as restorative materials in Atraumatic Restorative Treatment (dental restorations)	Data analysis completed	Intervention	2023-07-24	<NULL>	<NULL>	6264	Clinical evaluation of glass ionomer cements used in Atraumatic Restorative Treatment (ART)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2013-06-10	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3bbwwjz	<NULL>	Children and adolescents in good general health; aged between 10 and 15 years; both sexes; residents of the municipality of Sobral; present a collaborative behavior to carry out the clinical procedure; present at least one of the upper and/or lower permanent molars with cavitated dentin occlusal caries lesion accessible to manual instruments with a minimum opening of 0.9 mm; present the Informed Consent Term signed by the parents/guardians	Permanent molars with pulp exposure; fistula; abscess; pathological mobility; spontaneous pain; carious dentin lesion not accessible to hand instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-857nczs	Nursing intervention for reducing anxiety in individuals undergoing unscheduled cardiac catheterism	Data analysis completed	Intervention	2023-07-24	<NULL>	<NULL>	6265	Nursing intervention for reducing anxiety in individuals undergoing unscheduled cardiac catheterism: pilot study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-19	Escola de Enfermagem da Universidade de São Paulo	Instituto do Coração	https://ensaiosclinicos.gov.br/rg/RBR-857nczs	<NULL>	People with acute coronary syndrome awaiting unscheduled catheterization, diagnostic or therapeutic, were included. Unscheduled catheterization was understood in this study as a percutaneous procedure not scheduled on an outpatient basis and performed due to the diagnosis of ACS after the individual&apos;s admission to the emergency unit. Individuals aged 18 years or older; literate; hemodynamically stable with or without the use of vasoactive drugs; and who were performing cardiac catheterization for the first time or for more than a year were included. Individuals with a diagnosis of psychiatric disorder and use of mood modulators, prescribed or not, were not included.	Individuals with hearing loss that prevented them from listening to music within the established parameters, who presented hemodynamic instability during data collection, were excluded; those whose therapeutic plan was modified and did not undergo the procedure and those who were interrupted for any reason while offering the musical component of the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-55bpxm4	Insertion of feeding tube in newborns: With or Without Air Insufflation in the Stomach	Recruitment completed	Intervention	2023-07-24	<NULL>	<NULL>	6266	Insertion of transpyloric tube in newborns: With or Without Gastric Insufflation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-55bpxm4	<NULL>	newborns; hospitalized; medical indication of transpyloric catheter feeding	congenital malformations in the abdominal wall; omphalocele; gastroschisis; diaphragmatic hernia; bowel obstruction; undergoing surgical intervention in the gastrointestinal system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-8tqs3cc	Immediate Effect of Electrical Stimulation on the Scalp on heart measurements in patients with Stroke	Not yet recruiting	Intervention	2023-07-24	<NULL>	<NULL>	6267	The immediate Effect of Transcranial Direct Current Stimulation (tDCS) on Cardiorespiratory parameters in adult hemiparetic patients with to stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-8tqs3cc	<NULL>	Hemiparetic adults diagnosed with Chronic Stroke;  with lesions in the left or right hemisphere; aged between 49 and 71 years; able to walk independently; have signed the consent document	Participants with cognitive deficits; visual impairment; severe heart problems; pacemaker use; transcranial Direct Current Stimulation contraindications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-9d23t9t	The effect of using an application in the care of Overweight or Obesity adults in Primary Health Care	Not yet recruiting	Intervention	2023-07-21	<NULL>	<NULL>	6260	Efficacy of interventions mediated or not by Technologies in the care of Overweight or Obesity adults in Primary Health Care: A trial randomized community	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Federal de Ouro Preto	Ministério da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-9d23t9t	<NULL>	People who are overweight or obesity (BMI ≥ 25Kg/m2): adults over 18 and under 60 who have a compatible device and availability/interest to download the mobile app.	"Children; adolescents; pregnant women; elderly with or without excess weight and
obesity; Adult users in drug treatment for obesity; Adult users with body weight over 200kg."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-9pjd2n3	Study of functional mobility and cardiorespiratory function in women undergoing cesarean section after Lasertherapy and Transcutaneous Nerve Stimulation treatment	Recruiting	Intervention	2023-07-20	<NULL>	<NULL>	6255	Influence on the functional performance of the combined therapy of Laser and TENS in the cesarean section with pain: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-10	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Maternidade Divino Amor	https://ensaiosclinicos.gov.br/rg/RBR-9pjd2n3	<NULL>	The volunteers must present between 8 and 12 hours of postpartum cesarean section; having pain on the numerical pain scale ≥ 3 in the region of the cesarean incision7; without clinical or obstetric intercurrences; no infectious process; they should receive the same drug treatment (anti-inflammatory, analgesic and anti-inflammatory drugs) with the same intake interval; postpartum woman with communication and expression difficulties to answer the evaluation questions; not presenting disorders and/or neurological alterations; not presenting musculoskeletal disorders and/or alterations; not being sedentary in the evaluation with the International Physical Activity Questionnaire	Women who give up performing the intervention with Transcutaneous Electrical Nerve Stimulation - TENS; women who give up performing the intervention with the Low Intensity Laser - LBI; volunteers who give up performing the 2 (two) minute walk test during the collection period; volunteers who present clinical and obstetric instability during the collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-10nsmwzt	Impact on adherence to treatment of patients with Diabetes at the basic health unit with telephone follow-up: a randomized clinical trial	Recruiting	Intervention	2023-07-20	<NULL>	<NULL>	6256	Impact on therapeutic adherence of users with type 2 Diabetes Mellitus in primary health care with telephone follow-up: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-02	Universidade Federal de São Paulo	Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-10nsmwzt	<NULL>	"Volunteers with type 2 diabetes mellitus; of both sexes; aged from 30 years old; who are
registered and are monitored by the basic health unit"	Volunteer with type 1 diabetes mellitus; who are not registered or are not monitored by the basic health unit	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-89q4ydz	Action of Curcuma Longa and Piperine on the oxidative and inflammatory profile of patients with Inflammatory Bowel Disease: a randomized, double-blind, placebo-controlled study	Terminated	Intervention	2023-07-20	<NULL>	<NULL>	6257	Effect of supplementation with Curcuma Longa (extract) and Piperine on inflammatory markers, oxidative stress and glycoxidation in patients with Inflammatory Bowel Disease treated at a Teaching Hospital in Alagoa	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-02	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-89q4ydz	<NULL>	Patients diagnosed with IBD (Crohn&apos;s Disease, Ulcerative Colitis or Unclassified Colitis) of mild to moderate intensity; age equal to or greater than 18 years and up to 80 years; Patients using conventional drug therapy for IBD (aminosalicylates, immunosuppressants, biological); Function preserved kidney and liver	Pregnancy; Change or withdrawal of dosage/conventional medication for IBD; HIV positive patients and compromised renal and hepatic function; Patients who made inadequate use of supplementation (did not ingest the recommended daily dose)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-7m7yjdj	Evaluation of the effectiveness of Boric Acid in an ear dressing for the treatment of an infectious process in temporal bone cavities	Recruiting	Intervention	2023-07-20	<NULL>	<NULL>	6258	Evaluation of the effectiveness of Boric Acid in otological bandage for treatment of infectious process in mastoid cavities: randomized and blind clinical study	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-06-24	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7m7yjdj	<NULL>	Has been subjected to Wall Down mastoidectomy; is presenting active infectious framework at the moment	Is using topical and/or systemic antibiotic therapy; Cholesteatoma recurrence diagnosis; has been subjected to mastidectomy wall up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-29xp74c	Social and Economic Consequences after COVID-19: Effect of the Loss of Physical Capacity on Health, Social Relationships and Work Capacity	Recruiting	Observational	2023-07-20	<NULL>	<NULL>	6259	Social and Economic Impacts of the Post-COVID Syndrome: The Global and Systemic Effects of Reduced Physical Fitness on Health, Social Illness and Productive Capacity	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade de Brasília	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-29xp74c	<NULL>	Patients aged more than 18 years of age, of both sexes, with a history of COVID-19 in the acute symptomatic form of all severities, and who still have symptoms or the presence of sequelae in heart or lungs after 3 months of the acute condition.	Incomplete acquisition of clinical information; inability to exercise; refusal to participate in the research protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-7s77chz	The effect of FIFA11+ to prevent lower limb injuries in volleyball athletes	Recruiting	Intervention	2023-07-19	<NULL>	<NULL>	6253	The effectiveness of FIFA11+ to prevent lower limb injuries in volleyball athletes: a cluster-randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Instituto de Ciências da Saúde da Universidade Federal do Pará - ICS/ UFPA	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7s77chz	<NULL>	female; aged 13 to 18 years; competing for at least 6 months at regional level; who train at least 2 times a week and fulfill the training loads and competitions of their teams	practitioners of another sport modality simultaneously; of another category; who have carried out any injury prevention program in the last 6 months; and who refuse to sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-684gwrv	Effects of Self-selected and Moderate-intensity Exercise on Anxiety in young people exposed to unpleasant images before or after exercise	Recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6246	Acute effects of Self-selected Intensity Aerobic Exercise and Moderate Intensity Aerobic Exercise on state-anxiety levels in young people exposed to unpleasant stimuli before or after exercise	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-684gwrv	<NULL>	Age between 18 and 40 years old.	Being on your period (for people with a uterus); irregular menstrual cycle (for people with a uterus); have any contraindication on physical activity performance, verified through the Physical Activity Readiness Questionnaire; any type of cardiac, endocrine, orthopedic and metabolic dysfunction; and, to be literate, as there will be a need for the participant to respond to instruments, such as questionnaires, scales and inventories	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-4pc8c47	Physiological and psychological responses promoted by a beach tennis session	Not yet recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6247	Comparison of physiological and psychobiological responses promoted by a beach tennis session in single and double mode	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-05	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	Faculdade de Educação Física e Dança da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-4pc8c47	<NULL>	Age between 18 and 40 years; both sexes; minimum of two months of experience in beach tennis; be literate	Contraindication for performing physical activity (PAR-Q); having some type of musculoskeletal injury; being on your period; discontinuity in the research and e) not having the complete immunization cycle of COVID-19.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9ghqkdx	Effect of systemic Corticosteroid use after Maxillary Sinus Lift Surgeries	Not yet recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6248	Postoperative Period inMaxillary Sinus Lift	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-31	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9ghqkdx	<NULL>	Volunteers patients (18 years of age or older); both sexes; patients in need of maxillary sinus lift surgery	Volunteers with previous chronic or acute pain; volunteers in chronic or acute systemic use (in the 48 hours prior to the procedure) of analgesic, anti-inflammatory and/or muscle relaxant; volunteers with difficulty in understanding instructions (cognitive changes), which impair the application of the scales proposed by the study; illiterate volunteers; volunteers with contraindications for the use of paracetamol associated with codeine; volunteers with contraindication for the use of dexamethasone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-47nqzj2	Effects of Osteopathic Manipulative Treatment in women with Intestinal Constipation	Not yet recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6249	Effects of Osteopathic Manipulative Treatment in women with Functional Constipation: pragmatic randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Univerisade Estadual do Oeste do Paraná	Univerisade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-47nqzj2	<NULL>	Women; age range from 18 to 60 years; present functional constipation as mentioned in the ROME III criteria (LONGSTRETH et al., 2006)	Not accepting manipulations; pregnant women; being in the inflammatory phase of gastrointestinal or urinary diseases (kidney stones, appendicitis, colicistitis, peritonitis); presenting metabolic or cardiovascular diseases; having already undergone some surgical procedure on the spinal column or abdominal cavity; having undergone some type of treatment for constipation less than 6 months ago, such as: use of laxative medications and body massages or teas that alter intestinal motility; present contraindications for the Osteopathic techniques to be performed during the collection of the study, these being: recent fracture, osteoporosis and spinal tumor (PANAGOPOULOS et al. , 2015; FERNANDES et al., 2018)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-65yq5jx	Immediate effect of music on motor learning assessed by mobile device in children	Recruitment completed	Intervention	2023-07-18	<NULL>	<NULL>	6250	Immediate effect of music on the electroencephalographic activity of children undergoing learning	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-28	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-65yq5jx	<NULL>	The study included children between 8 and 10 years old; both sexes; right laterality; children duly enrolled at the Tereza Paulino da Costa Municipal School (Alfenas-MG)	Children who showed some impairment of neuropsychomotor development; who did not accept the assent form or whose legal guardians did not agree with the free and informed consent form for parents or guardians were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-64ktszb	Autonomic Telerehabilitation in patients with Vasovagal Syncope	Recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6251	Influence of sleep duration in the occurrence of Vasovagal Syncope treated with Autonomic Rehabilitation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal de São Paulo	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-64ktszb	<NULL>	Patients with a clinical diagnosis of vasovagal syncope with at least 1 syncope episode or 2 pre-syncope episodes in the last 3 months; both sexes; aged between 18 and 65 years	Shift workers; patients with neurological diseases; diabetes mellitus; morbid obesity; pregnant women; previous cardiovascular events; obstructive sleep apnea; disabling illnesses; cognitive impairment; eye diseases that affect the pupillary reflex; history of anterior segment trauma; history of eye surgery; users of eye drops or systemic drugs that affect pupillary diameter; volunteers without internet access; patients who did not reach the minimum recommended performance in functional capacity tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-8z24xpw	Impact of the Ventilatory Transfer Technique on the lung expansion of premature newborns admitted to a neonatal intensive care unit	Recruiting	Intervention	2023-07-18	<NULL>	<NULL>	6252	Physiotherapy in newborns admitted to the neonatal ICU	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8z24xpw	<NULL>	Preterm newborns born at the Hospital de Clínicas of the Federal University of Paraná, admitted to the Neonatal ICU of the same institution, of both sexes, with chronological age from 7 days of life, who are without respiratory support	Newborns with hemodynamic instability; requiring vasoactive drugs; contraindication for the use of the technique; chest drain; thrombocytopenia; pulmonary hemorrhage; pulmonary hypertension; immediate postoperative period of thoracic and abdominal surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-10z2n67v	Teaching-learning process of manipulation External Ventricular Drain in a pediatric patient: use of the Rapid Cycle Deliberate Practice in the simulated scenario	Recruitment completed	Intervention	2023-07-18	<NULL>	<NULL>	7053	Teaching-learning process of handling External Ventricular Drain in a pediatric patient: use of the Rapid Cycle Deliberate Practice in the simulated scenario	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-07-20	Universidade Estadual de Campinas	Faculdade de Enfermagem da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10z2n67v	<NULL>	Healthy students; both genders; of any age; enrolled in the higher education unit in nursing	Students on sick leave; not enrolled in the higher education unit in nursing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:06
RBR-353xkdp	Sleep analysis in eSports players and its relationship with performance	Recruiting	Observational	2023-07-17	<NULL>	<NULL>	6244	Analysis of the sleep-wake cycle in eSports athletes and its relationship with performance	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-01	Unversidade Estadual de Campinas	Unversidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-353xkdp	<NULL>	Expanded group – both genders; minimum age of 18 years; play video games at least 2 hours a day, three times a week. Reduced group - eSports athlete of both genders; minimum age of 18 years;  participate in official competitions of the modality practiced by him;  present a high classification in the specific ranking of the game	People who don&apos;t play video games	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9gtr9sc	Effect of Tooth Enamel humidity on Tooth Whitening using High-concentration Carbide Peroxide: A Randomized Clinical Trial	Not yet recruiting	Intervention	2023-07-14	<NULL>	<NULL>	6240	Effect of Enamel humidity on the action of High-concentration Carbide Peroxide: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-24	Universida Federal de Sergipe	Universida Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9gtr9sc	<NULL>	Any individual who is interested in teeth whitening at least 18 years of age, patients who have a color equal to or darker than 2.5 M2 on the maxillary anterior canines (on the Vita Bleach Guide scale) and agree to participate and sign the informed consent form	Presence of restorations in the upper anterior teeth, presenting any pre-existing general medical and/or oral condition that put the individual at risk during the study, such as systemic fungal infections, being pregnant or breastfeeding, dental treatment planned to be performed during the course of the study , generalized periodontal disease, complex intrinsic staining due to tetracycline, fluorosis or hypocalcification, and previous tooth sensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-4n525b2	Effects of different intensities of physical exercise on mood and biochemical markers of individuals with depressive disorder	Recruiting	Intervention	2023-07-14	<NULL>	<NULL>	6241	Effects of different intensities of physical exercise on the quinurenine pathway, mood states and affect in individuals with depressive disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-19	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4n525b2	<NULL>	Both genders. Age between 20 and 45 years. With a minimum schooling time of 8 years. affected or not by depressive disorder, the latter with a diagnosis of at least 3 months. Considered minimally active. Considered in good health after medical evaluation. They must not have undergone surgery in the last 6 months. Must not have any physical, muscle and/or joint problems	Those who, for whatever reason, do not complete the tests within the stipulated period will be excluded from the sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-3w8mnrv	Development and application of a Family-Centered Approach for children with Cerebral Palsy and their families in Brazil	Recruiting	Intervention	2023-07-14	<NULL>	<NULL>	6242	Development and applicability of a Family-Centered Approach of children with Cerebral Palsy in Brazil	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-04	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP)	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP)	https://ensaiosclinicos.gov.br/rg/RBR-3w8mnrv	<NULL>	Children with a previous diagnosis of cerebral palsy or at high risk of delay in neuropsychomotor development identified from screening by the Hammersmith Child Neurological Examination - HINE; age group 0-6 years; both genders; parents&apos; agreement to participate in the research by signing the Free and Informed Consent Form; be undergoing physiotherapeutic treatment previously	Child with a different diagnosis of cerebral palsy; children with difficult-to-control epilepsy; children with other syndromes associated with cerebral palsy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-255jzz9	Evaluation of new material for teeth restorations: clinical trial	Recruiting	Intervention	2023-07-14	<NULL>	<NULL>	6243	Clinical evaluation of a novel composite resin in posterior teeth: a double-blind, randomized, clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-03	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-255jzz9	<NULL>	Healthy participants; of both genders; with an acceptable level of oral hygiene; of both genders; age between 18 and 60; present at least 20 teeth in occlusion; each participant must require at least three Class I or Class II restorations on vital teeth that are similar in horizontal and vertical dimensions; agree and sign the Informed Consent Form	Participants with extremely poor oral hygiene; with chronic or severe periodontitis (teeth with probing pocket depth greater than 4 mm with bleeding on probing and clinical attachment loss greater than 3 mm in more than 4 teeth); with the use of orthodontic appliances; with more than 10 teeth with occlusal wear (premolars and molars); with a known allergy to resin-based materials or any other material used in this study; pregnant or lactating women; using anti-inflammatories or analgesics or psychotropic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-6vfbzj6	Validation of the questionnaire for Portuguese (Brazil) and evaluation of the effect of the Posthumous Dignity Therapy intervention in bereaved informal caregivers	Not yet recruiting	Intervention	2023-07-14	<NULL>	<NULL>	7407	Posthumous Dignity Therapy: validation of the questionnaire for Portuguese (Brazil) and evaluation of the effect of the dignity therapy intervention in bereaved informal caregivers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2024-11-01	Instituto de Câncer de Londrina	Instituto de Câncer de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-6vfbzj6	<NULL>	Bereaved informal caregivers of patients cared for by the Oncology Palliative Care Team at the Londrina Cancer Hospital; informal caregivers of patients in the active death process or who have already died cared for by the Team; over 18 years of age of both genders; previously elected by patients or the healthcare team as the patients’ main caregivers; who write, speak or read Brazilian Portuguese; with cognitive capacity to understand questions and answers, which will be evaluated by the researcher; willing to meet researchers for up to 3 consecutive meetings at an interval of approximately 45 days in total, in person or online	Previous or ongoing psychiatric disorders; caregivers presenting criteria for diagnosis of depression using the PHQ-9 questionnaire (9-item Patient Health Questionnaire), which will be applied before the TCLE (Informed Consent Form), with the aim of screening for suicidal ideation or depression	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:19
RBR-37f4x5p	Results of Physical Exercise in women with Breast Cancer undergoing Chemotherapy	Data analysis completed	Intervention	2023-07-13	<NULL>	<NULL>	6235	Effect of Physical Exercise on Functionality and Tumor Size in women with Breast Cancer undergoing Neoadjuvant Chemotherapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-18	Universidade Federal de Minas Gerais	Instituto de Previdência dos Servidores do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-37f4x5p	<NULL>	women diagnosed with breast cancer; aged between 18 and 69 years old; undergoing neoadjuvant chemotherapy	women with breast cancer; undergoing neoadjuvant chemotherapy who present some comorbidity such as cardiac dysfunctions that contraindicate the practice of physical exercise or present some inability to answer the questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-7bshzcg	Effects of Dermocosmetics and Ultrasound for Lasertherapy	Recruiting	Intervention	2023-07-13	<NULL>	<NULL>	6236	Effects of Optical Clearing Agent, Ultrasound Therapy and Sonophoresis for Photobiomodulation: randomized clinical trial	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7bshzcg	<NULL>	White, brown and black men and women. Body mass index (BMI) between 18.5 and 29.9 kg/m2. Skin fold in the vastus medialis area measuring up to 25 mm	Hypersensitivity to OCA-IPQ, such as redness and itching; skin lesions in the vastus medialis region such as open wounds; tattoos; history of skin cancer; cognitive difficulty reporting thermal sensation; pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-4x9kcbf	Reduction of Heart Issues in individuals with Paraplegia through Physical Activity	Not yet recruiting	Intervention	2023-07-13	<NULL>	<NULL>	6237	Reduction of Cardiovascular Combities in people with Paraplegia through a Physical Rehabilitation Program	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-13	Faculdade de Medicina de Campos	Faculdade de Medicina de Campos	https://ensaiosclinicos.gov.br/rg/RBR-4x9kcbf	<NULL>	Eligibility criteria will be age between 18 and 65 years, chronic spinal cord injury more than1 year post-injury; self-reported wheelchair use for more than 75% of your waking day; stable weight in the past 3 months	Individuals who self-report the use of medication for type 2 diabetes or medication that affect glucose metabolism and those who have a fracture or dislocation; uncontrolled inflammatory disease or those prevented from performing physical activity for any clinical reason will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-8yjfpmk	Clinical evaluation of the match and color stability between one shade composite resin and teeth	Recruiting	Intervention	2023-07-13	<NULL>	<NULL>	6238	Clinical evaluation of the match and color stability of monochromatic composite resin – randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-8yjfpmk	<NULL>	Adults presenting a non-carious cervical lesion with indication for class V restoration on the buccal surface; Having non-carious cervical lesions in different quadrants; No pain or pulp alteration in the tooth to be restored; Consent to participate in the research	Severe or active periodontal disease; Use fixed orthodontic appliance; rampant caries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9qks3pc	Effect of testosterone replacement associated with bariatric surgery in men with obesity	Recruiting	Intervention	2023-07-13	<NULL>	<NULL>	6239	Effect of testosterone replacement associated with bariatric surgery in men with obesity: a randomized trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Hospital e Maternidade São Domingos	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-9qks3pc	<NULL>	Patients with Body Mass Index - BMI &gt; 35; weighing up to 180 kg; with low testosterone levels (&lt;350 ng/dl); classified as hypogonadal; who voluntarily agreed to participate in the research, in addition to understanding and consenting to participation through the TCLE (Free and Informed Consent Form)	Interest in fertility in the 6 months following therapy; diagnosis of active prostate or breast cancer; previous diagnosis of prostate cancer, with less than two years of curative treatment; previous diagnosis of breast cancer; severe voiding symptoms, translated through the IPSS score (International Prostatic Symptom Score) &gt; 19; severe cardiopulmonary disease (eg unstable angina, recent myocardial infarction); personal or family history of thromboembolism; hematocrit above 48%; patients with implanted medical devices such as pacemakers or essential support devices such as monitors	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-8vrq4m5	Follow-up clinical study of teeth treated with Fiberglass Post and national Restorative Materials	Recruiting	Intervention	2023-07-13	<NULL>	<NULL>	7742	Prospective clinical study of endodontically treated teeth rehabilitated with Fiberglass Post using National Restorative Materials	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-01-10	Universidade Federal de Uberlândia Faculdade de Odontologia	FGM Dental Group	https://ensaiosclinicos.gov.br/rg/RBR-8vrq4m5	<NULL>	Adult patients; older than 18 years; of both genders; in need of endodontic treatment; restoration in anterior and/or posterior teeth; with great coronary destruction; the use of fiberglass post is indicated; patient who has a medical history that does not compromise the evolution of results; who has the habit of brushing his teeth at least once a day; who has a normal periodontal condition compared to probing parameters	Patients under 18 years of age; chronic disease with oral manifestations; oral pathology considered serious; patients with no oral hygiene; patients with periodontal disease; patients allergic to any material that will be used at work	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-4fn5b4p	Additional Effect of Transcutaneous Electrical Stimulation on the Efficacy of Inferior Alveolar Nerve Anesthesia in Irreversible Pulpitis: a randomized placebo-controlled clinical trial	Recruitment completed	Intervention	2023-07-12	<NULL>	<NULL>	6228	Effect of Pain Inhibitory Modulation Techniques on Blockade Analgesic Efficacy Inferior Alveolar Nerve Anesthetic in Irreversible Pulpitis: A clinical trial randomized placebo controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-01	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4fn5b4p	<NULL>	Clinical diagnosis of unilateral symptomatic irreversible pulpitis in mandibular premolars and molars	Allergy to ketorolac or the anesthetic used; history or presence of uncontrolled systemic diseases; chronic pain; neurological; hormonal; rheumatic; psychiatric disorders; pregnancy; lactation; pacemaker presence	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-4ddtqts	Ozone therapy on pain and functionality of individuals with low back pain	Recruiting	Intervention	2023-07-12	<NULL>	<NULL>	6229	Evaluation of the effects of ozone therapy on pain and functionality of individuals with chronic low back pain: a controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-4ddtqts	<NULL>	non-specific chronic low back pain defined as pain or discomfort between the costal margins and inferior gluteal folds with or without pain referred to the lower limbs; persistent symptoms for at least 3 months; both sexes; age between 35 to 60 years	people with severe pathologies of the spine (tumors, inflammatory and infectious diseases), history of previous spine surgery, pregnancy; use of conventional, unconventional or alternative treatments that could potentially have an effect on the study results (physiotherapy and/or intra-articular corticosteroid or hyaluronic acid injections during the last 3 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-5rmxgnb	&quot;Comparing the Well-being of Physicians  Network-Based Medical Residency of the Department of Public Health of the City of São Paulo and of Irmandade da Santa Casa de Misericórdia de São Paulo&quot;	Not yet recruiting	Observational	2023-07-12	<NULL>	<NULL>	6230	Comparative Study on the Well-being of Resident Physicians of the Network-Based Medical Residency of the Department of Public Health of the City of São Paulo and of Irmandade da Santa Casa de Misericórdia de São Paulo	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-01	Irmandade da Santa Casa de Misericórdia de São Paulo	Irmandade da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5rmxgnb	<NULL>	Resident physicians ; both sexes ; between 18 and 60 years old ; agree to participate in the study	Non-agreement to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-3vxgjsj	Prospective Evaluation of the Use of PET-CT in Hepatocarcinoma	Recruiting	Observational	2023-07-12	<NULL>	<NULL>	6231	Prospective Evaluation of the Use of PET-CT with 18 F -PSMA in Hepatocarcinoma: Comparison With Conventional Morphological Methods and Impact on Management Change	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-01	Fundação Antônio Prudente - AC Camargo Cancer Center	Fundação Antônio Prudente - AC Camargo Cancer Center	https://ensaiosclinicos.gov.br/rg/RBR-3vxgjsj	<NULL>	A total of 30 patients diagnosed with established hepatocellular carcinoma will be prospectively included and analyzed with the 18F-PSMA (Fluorine-18 Prostate specific Membrane Antigen)  PET/CT (Positron emission tomography) study	none	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-5qq46rb	Effectiveness of an intervention on physical activity and eating behavior in adolescents	Not yet recruiting	Intervention	2023-07-12	<NULL>	<NULL>	6232	Effectiveness of a school-based intervention on stages of behavior change related to physical activity and diet in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-5qq46rb	<NULL>	First year high school students; regularly enrolled in the selected schools; of both genders; between 13 and 18 years of age; not having physical and/or mental limitations that would prevent their participation in the stages of the study; having parental consent through the signing of the TCLE (Free and Informed Consent Form); having agreed to and signed the TALE (Free and Informed Consent Form)	Students not enrolled in the first year of high school in the selected schools; not meeting the minimum and maximum ages established; having physical and/or mental limitations that prevent their participation in the stages of the study; not having parental consent through the signing of the TCLE (Free and Informed Consent Form); not having agreed to and signed the TALE (Free and Informed Consent Form)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-2jpr96k	Impact of the use of mobile applications in the treatment of patients in hemodialysis - randomized clinical trial	Recruitment completed	Intervention	2023-07-12	<NULL>	<NULL>	6233	Use of Mhealth technology: impact on the treatment of patients with chronic kidney disease on hemodialysis - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2jpr96k	<NULL>	Patients who have been undergoing treatment for at least three months, who understand Portuguese, have a smartphone and know how to handle it	Patients with advanced stage dementia indicated in the medical record, including Parkinson&apos;s and Alzheimer&apos;s disease, and significant cognitive impairment; Patients with hearing and visual impairment; Patients undergoing hemodialysis temporarily at the study site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9jynn64	Intervention based on mindfulness on levels of emotional response, mindfulness and stress in nursing students: clinical trial randomized	Not yet recruiting	Intervention	2023-07-12	<NULL>	<NULL>	6234	Mindfulness based intervention on levels of emotion regulation, dispositional mindfulness and perceived stress in nursing students: clinical trial randomized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Univerdidade do estado de Mato Grosso	Univerdidade do estado de Mato Grosso	https://ensaiosclinicos.gov.br/rg/RBR-9jynn64	<NULL>	Students regularly enrolled in the ninth and tenth phase of the undergraduate nursing course; over eighteen years old	Have previously participated, at least once a week, in some type of meditation in the last twelve months; being under treatment with the use of psychotropic drugs; have physical contraindications to the exercises that will be performed during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:36
RBR-9c4jnv4	Effects of Photobiomodulation and Ozone Therapy on pain and functionality in knee osteoarthritis	Recruiting	Intervention	2023-07-12	<NULL>	<NULL>	7221	Comparative analysis of the effects of Photobiomodulation and Ozone therapy on pain and functionality of individuals with knee osteoarthritis: Controlled and Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9c4jnv4	<NULL>	diagnosis of knee osteoarthritis (KOA) grades II and III confirmed by radiological examination according to the American College of Rheumatology - Kellgren-Lawrence criteria (Link et al., 2013); women; age between 50 and 70 years; body mass index (BMI) between 22 and 30 kg/m²; classified as little active and irregularly active according to criteria established by the International Physical Activity Questionnaire – short version (IPAQ); availability to participate in the treatment plan; clinical signs such as pain and joint stiffness in at least one of the compartments of the knee joint (medial or lateral tibiofemoral and patellofemoral joint)	medical restrictions that make it impossible to participate in the study evaluations (cardio-respiratory, rheumatic, neurological and vestibular alterations); systemic arthritis; body mass index greater than 30 kg/m2; symptomatic hip osteoarthritis (OA); use of conventional, unconventional or alternative treatments that could potentially have an effect on the study results (physiotherapy and/or intra-articular corticosteroid or hyaluronic acid injections during the last 3 months)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-29z46fh	Adjunctive Vocational Orientation to Good Psychiatric Management for Adolescents with Borderline Personality Disorder: Randomized Clinical Trial	Recruitment completed	Intervention	2023-07-12	<NULL>	<NULL>	7809	Vocational Orientation as a complementary strategy in the treatment of adolescents with Borderline Personality Disorder: effects on clinical symptoms and in positive mental health	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-29z46fh	<NULL>	Adolescents; literate; aged 13-17 years; all genders; both sex; with 3 or more criteria for Borderline Personality Disorder; agree to sign the Informed Consent Form	Adolescents with intellectual disabilities (IQ&lt;80); primary psychoses; decompensated bipolar affective disorder; decompensated anorexia; severe neurological problems; conduct disorder with limited pro-social emotions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:33
RBR-5x9n573	Use of Platelet Rich Plasma associated with Ozone Therapy in skin rejuvenation	Recruiting	Intervention	2023-07-11	<NULL>	<NULL>	6221	Skin rejuvenation: use of Platelet Rich Plasma (PRP) and its association with Ozone Therapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-06	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-5x9n573	<NULL>	women; age range of 40 and 60 years; phototype II to IV according to the Fitzpatrick scale; presence of signs of facial photoaging grade II to IV according to the Glogau scale; blood count with normal platelet count (150,000 to 350,000 uL); consent to participate in the study to sign the informed consent;	smokers; pregnant or breastfeeding women; history of neoplasia; ablative chemical or physical peeling in the last 6 months; use of botulinum toxin or fillers with facial implants with absorbable material in the last six months; performance of surgical procedures (rhytidoplasty and/or blepharoplasty); patient unable to use photoprotection throughout the treatment period; patients with a history of keloids or hypertrophic scarring; patients with infected or inflamed skin lesion on the face in the last 12 months; underlying diseases such as uncontrolled systemic arterial hypertension; renal liver disease; hematological (coagulopathies and/or purpura, glucose 6-phosphate deficiency); inflammatory; rheumatological; with diabetes; platelet count below 150,000/uL; of hypersensitivity to ozone therapy treatment; refusal to sign the informed consent form; still, the discontinuity criteria were established: withdrawal of the participants; two consecutive absences; present any disorder/infection that implies the use of antibiotics throughout the study;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-6t4pryk	Laser for the treatment of individuals with chronic Low back pain	Recruiting	Intervention	2023-07-11	<NULL>	<NULL>	6222	Use of different energies of Photobiomodulation therapy for the treatment of individuals with non-specific Low back pain: a randomized, double-blind clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6t4pryk	<NULL>	Women and Men over 18 years of age; Presence of chronic low back pain (more than 12 weeks); Body mass index (BMI) &lt; 30 kg/m2	Volunteers who have specific low back pain; Sacroiliac joint pain; Congenital malformation; Recent or lumbar spine surgeries; Neurological problems and pregnant women; Volunteers who have illnesses that prevent them from performing the protocol exercises; Who have performed physical training for at least 48 hours before the assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-2crspbc	Antispastic effect of Transcranial Magnetic Stimulation in Multiple Sclerosis	Recruitment completed	Intervention	2023-07-11	<NULL>	<NULL>	6223	Effects of Transcranial Magnetic Stimulation on spasticity in Multiple Sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-05	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2crspbc	<NULL>	over 18 years old; left lateral hemispheric dominance; confirmed diagnosis of multiple sclerosis; who present grade 3 spasticity according to the ashworth scale; the subtypes (remitting relapsing, primary progressive and secondary progressive); who have motor evoked potential for quadriceps	Application of phenol; botox or other procedures that interfere with quadriceps muscle tone within a period equal to or less than 6 months; Fracture or recent surgeries in lower limbs; Contracture or ankle deformity; History of seizures or refractory epilepsy; brain metallic implants; brain tumors or skin lesion at the application site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-2h6gdh7	Product Efficacy evaluation for Children&apos;s Diaper Rash	Not yet recruiting	Intervention	2023-07-11	<NULL>	<NULL>	6224	EN22-0674-04 – Comparative evaluation of the Efficacy of two products in improving Diaper Rash in children - clinical and subjective study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Medcin Instituto da Pele Ltda	Megalabs Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-2h6gdh7	<NULL>	Participants of both sexes; age between 3 months and 2 years and 11 months; diaper wearers; with irritant diaper dermatitis; with mild to moderate intertrigo, mild or clear erythema, without maceration, erosion or signs of infection in the area where the diaper is used; at least one parent or legal responsible willing to follow the trial procedures and attend the clinic on the days and times determined for applications and/or evaluations; at least one parent or legal responsible of the participants must understand, agree and sign the Informed Consent Form (TCLE)	Participants and parents or legal responsible who have been diagnosed with COVID-19 in the last 4 weeks or who are experiencing symptoms such as fever, dry cough, tiredness, body aches or other discomforts; use of anti-inflammatory/immunosuppressive/antihistamine drugs up to 3 weeks before selection; atopic or allergic history to cosmetic products; immunosuppression by drugs or active diseases; decompensated endocrinopathies; known history of or suspected intolerance to products in the same category; intense sun exposure up to 15 days before the assessment; aesthetic or dermatological treatment up to 4 weeks before the evaluation; children of employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-10mpz6sd	Clinical trial to evaluate monkeypox vaccine response in persons previously exposed to monkeypox virus	Recruiting	Intervention	2023-07-11	<NULL>	<NULL>	6225	Adaptive clinical trial to evaluate the Post-Exposure Effectiveness and Safety of the MVA-BN/ Jynneos vaccine for Mpox	<NULL>	4, n/a, open	4	<NULL>	<NULL>	<NULL>	2022-12-13	Instituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-10mpz6sd	<NULL>	Minimum age of 15 years. Both genders. Had contact with an individual diagnosed with suspected, probable or confirmed Mpox by PCR RT and with a high degree of exposure characterized as: contact of continuity lesions on the skin (non-integrated/mucous skin) or mucous membranes of the exposed individual with skin lesions or body fluids of person with Mpox. Had any sexual contact or intimate relationship involving mucous membranes (e.g. kissing, oro-genital contact, oro-anal contact, vaginal contact, or anal sex) with a person with Mpox. Had contact of skin lesions (non-integrated/unhealed skin) or mucosal contact of the exposed individual with materials (e.g., fomites, clothing, sex toys) that have had contact with the skin lesions or body fluids of the person with Mpox (e.g., sharing food, handling or sharing fomites (bedding) without washing them). Professional accidentally exposed to the biological sample of a patient diagnosed with Mpox. Be available to perform the project visits. To sign the Free and Informed Consent Form and/or the Term of Consent, the latter in the case of minors under 18 years of age	Known allergy to any of the vaccine components, especially with severe forms of allergy to egg, quinolone class antibiotics and/or aminoglycosides. Pregnant and lactating women. Presenting signs and/or symptoms of Mpox (sudden onset of mucosal lesion), and/or acute rash suggestive of Mpox, single or multiple, anywhere on the body (deep and well circumscribed lesions, often with central umbilication; and progression of the lesion through specific sequential stages - macules, papules, vesicles, pustules, and crusts), including genital/perianal, oral, and/or proctitis - e.g. anorectal pain, bleeding – and/or penile edema, and may be associated with other signs and symptoms). Have received any Mpox vaccine in the last 12 (twelve) months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-8ygjpqm	Evolution of patients who underwent surgery for cancer treatment in Brazil during the COVID-19 pandemic	Data analysis completed	Observational	2023-07-11	<NULL>	<NULL>	6226	Prognosis of surgical oncology patients during the COVID-19 pandemic in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-03-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital do Câncer de Barretos - Fundação Pio XII	https://ensaiosclinicos.gov.br/rg/RBR-8ygjpqm	<NULL>	All patients undergoing surgeries for cancer treatment performed between March and June 2019 and between March and June 2020, who underwent postoperative care in the intensive care unit; with a minimum age of 18 years; both genders	Advanced cancer with no prospective of treatment, severe hepatic failure (Child C); hospital stay less than 12 hours; patients who undergo reoperation before inclusion in the study; readmission to intensive care unit during the same hospital stay of study inclusion; previously included patients; pregnant patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-36x4c4d	Cannabidiol as a treatment in patients with movement disorder	Recruitment completed	Intervention	2023-07-11	<NULL>	<NULL>	6227	Cannabidiol as a therapy for spinocerebellar ataxia	<NULL>	1, single-arm-study, single-blind	1	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-36x4c4d	<NULL>	Patients from the Movement Disorders Outpatient Clinic of the Neurology Service of the Hospital de Clínicas - UFPR (HC - UFPR) over 18 years old who already had the genetic diagnosis of spinocerebellar ataxia type 10 (SCA10); patients who agreed and signed the Informed Consent Form.	Patients who did not agree with the Informed Consent Form; patients who did not have a genetic diagnosis of SCA10; demented patients; and patients who did not use the intervention correctly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-56nsh92	Effects of meals rich in ultra-processed foods on the metabolism of overweight individuals	Data analysis completed	Intervention	2023-07-11	<NULL>	<NULL>	8028	Effects of meals rich in ultra-processed foods compared to meals without ultra-processed foods on energy metabolism, satiety hormones, and autonomic function in individuals with excess weight	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Univerisidade Federal de Alagoas	Univerisidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-56nsh92	<NULL>	Individuals aged between 19 and 60, with obesity defined by 2 of the 3 following criteria: body mass index between 25 and 40 kg/m2; waist circumference greater than or equal to 88 cm for women and greater than or equal to 102 cm for men; body fat percentage greater than or equal to 35% for women and greater than or equal to 25% for men, determined by bioelectrical impedance; who want to lose weight, but who have had a stable weight for at least 1 month at the time of inclusion	Individuals using chronic medications (antidiabetics, antiretrovirals, immunosuppressants, antidepressants); celiac or gluten-sensitive individuals; vegetarians or vegans; who have a condition that makes it impossible to perform anthropometry or measure the components of energy expenditure; menopausal women; pregnant women or nursing mothers; or who have already undergone any surgical intervention for weight loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-4r29z32	Evaluation and rehabilitation of post-Covid-19 patients	Recruitment completed	Intervention	2023-07-10	<NULL>	<NULL>	6218	Multidisciplinary assessment and rehabilitation of post-Covid19 patients: physical, neurophysiological, immunological, microbiological, psychological and nutritional aspects	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-10	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4r29z32	<NULL>	Individuals of both genders; aged 18 years or older and a maximum of 60 years; who agreed to participate in the survey and signed the informed consent form and who were not participating in other similar surveys; all participants had a confirmed or suspected diagnosis of COVID-19 with symptoms that started in February 2020, according to the 2020 protocol of the Brazilian Ministry of Health, who were discharged from the hospital a maximum of three months ago	Patients who are unable to carry out the proposed evaluations; have more three consecutive absences from training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-32qgytk	The effect of Social Skills on the marital relationship of people with Anxiety symptoms	Not yet recruiting	Intervention	2023-07-10	<NULL>	<NULL>	6219	Social Skills training in people with Anxiety and marital satisfaction	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-07	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-32qgytk	<NULL>	Participants over 18 years old; minimum of 1 in the affective relationship; low repertoire of social skills; anxiety symptoms; marital dissatisfaction	Participants with diagnosed psychiatric disorder; who are under psychological and/or psychiatric follow-up; couples who both volunteer; participants with approximation or any kind of bond with the interns who will carry out the interventions; incompatibility with the time of the intervention; psychology students or psychology professionals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-5kx6drp	Evaluation of protein supplement consumption on the body composition of Hematopoietic Stem Cell Transplantation patients	Recruitment completed	Intervention	2023-07-09	<NULL>	<NULL>	6216	Evaluation of  protein supplementation in body composition and clinical outcome of Hematopoietic Stem Cell Transplantation patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto	Fundação Pio  XII	https://ensaiosclinicos.gov.br/rg/RBR-5kx6drp	<NULL>	Age greater than or equal to 18 years; both genders; diagnosis of hematological neoplasms; with indication of the first allogeneic stem cell transplantation	Acute kidney injury; chronic kidney disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-10s52xg3	Voice changes by using the Shaker® device	Recruitment completed	Intervention	2023-07-09	<NULL>	<NULL>	6217	Vocal modifications by using the Shaker®	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-10s52xg3	<NULL>	Age between 18 and 50 years; sign the Informed Consent Form	Presence of disease of cardiovascular origin; neurological or auditory disease; cleft lips and/or palate; facial or rib fractures; upper airway obstruction at the time of collection; severe kidney disorders; untreated pneumothorax; being a smoker; having performed previous speech therapy; not completing all stages of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-3z757s5	Systematic training in psychiatric emergencies for health professionals	Recruitment completed	Intervention	2023-07-09	<NULL>	<NULL>	7879	Assessment of the impact of Systematic Training In Psychiatric Emergencies on health professionals	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal do Tocantins	Universidade Federal do Tocantins	https://ensaiosclinicos.gov.br/rg/RBR-3z757s5	<NULL>	Health professionals; aged between 20 and 50 years; both genders; and their undergraduate and graduate students	Other non-health related professions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-3vgndbw	Evaluation of the D-limonene effects on fat metabolism and blood glucose response after a meal consumption in postmenopausal women	Recruitment completed	Intervention	2023-07-07	<NULL>	<NULL>	6213	Study of the D-limonene effects on lipid metabolism and postprandial glycemic response in postmenopausal women	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-10-24	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3vgndbw	<NULL>	Women in post menopause period; Body Mass Index between 18.5 and 34.9 kilograms per square meter; age between 50 and 65 years	Bariatric surgery; gastrectomy; surgeries that alter the size of the stomach or intestine; inflammatory bowel diseases; celiac disease; gastric ulcers; liver diseases; cholecystectomy; diabetes; casein allergy; lactose intolerance; alcoholism; use of antimicrobial therapy at the time of the study and up to 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-9pq83b7	Self-Constructed Video laryngoscope a Simulated Trial with medical students	Recruitment completed	Observational	2023-07-07	<NULL>	<NULL>	6214	Self-constructed video laryngoscope: a simulated crossed randomized trial with Medical students and just graduated doctors	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-05	Santa Casa de Misericórdia Bahia	Santa Casa de Misericórdia Bahia	https://ensaiosclinicos.gov.br/rg/RBR-9pq83b7	<NULL>	Medical students; both sex; enrolled in 5th and 6th year	Student not willing to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-6z4jrs8	Effect of Prior Administration of the drug Ibuprofen-Arginine on the success of Anesthetic Block for Root Canal Treatment of posterior lower teeth with Symptomatic Pulpitis	Recruitment completed	Intervention	2023-07-07	<NULL>	<NULL>	6215	Effect of Preemptive Administration of Ibuprofene-Arginine on Anesthetic Block of the inferior alveolar nerve for Endodontic Treatment of teeth with Symptomatic Pulpitis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6z4jrs8	<NULL>	Be in good health; Be in the age group over 18 years; Present a clinical diagnosis of symptomatic pulpitis in posterior lower teeth; Ability to understand the pain assessment scale	Under 18 years old; pregnant women; Patients who have a previous sensitivity, allergy or who cannot take ibuprofen for any other reason; Patients allergic to local anesthetics or sulfites; Patients who have an important history of health problems; Patients unable to give informed consent; Patients who have ingested analgesics or anti-inflammatory drugs in the last 8 hours prior to treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-4b7v8pt	Excess Iron in people with Sickle Cell Disease: assessment of iron absorbed by the intestine	Recruitment completed	Observational	2023-07-06	<NULL>	<NULL>	6210	Iron Overload in people with Sickle Cell Disease: evaluation of the intestinal absorption of this nutrient	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade do Estado do Rio de Janeiro	Instituto Estadual de Hematologia Arthur Siqueira Cavalcanti	https://ensaiosclinicos.gov.br/rg/RBR-4b7v8pt	<NULL>	Children from 2 to 10 years old; adolescents aged 11 to 18 years; adults: from 19 to 59 years old, divided into three groups. In group 1, patients with sickle cell anemia with the SS genotype confirmed by HPLC and who are being followed up at the Hemorio hematology outpatient clinic, with a serum ferritin concentration equal to or greater than 1000 ng/mL; in group 2, patients with sickle cell anemia (SS genotype) confirmed by High Performance Liquid Chromatography (HPLC) and who are followed up at the Hemorio hematology outpatient clinic, with serum ferritin concentration below 1000 ng/mL; in group 3, healthy individuals who do not have sickle cell anemia proven by HPLC	Participants with sickle cell anemia who have been hospitalized and/or received transfusions in the last 15 days prior to the assessment; individuals in the group without sickle cell anemia who have sickle cell trait or other haemoglobinopathies, hematological diseases and/or who use medication for diabetes mellitus and hypo/hyperthyroidism and/or who have serum ferritin less than 10 ng/mL for women and less than 20 ng/mL for men. Pregnant women were also excluded from both groups.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-10fhfdt4	Effectiveness of Ozone Therapy Treatment of Endometriosis	Recruiting	Intervention	2023-07-06	<NULL>	<NULL>	6211	Effectiveness of Ozone therapy in the signs and symptoms of Endometriosis: controlled and randomizes study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-18	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-10fhfdt4	<NULL>	Women with Endometriosis with laboratory diagnosis; age group between 20 and 50 years; ability to respond to questionnaires; ability to consent to participation in the study and sign informed consent	Volunteers with a history of hysterectomy or oophorectomy; pregnant or breastfeeding women; BMI greater than 30kg/m2 have a history of previous physical abdominal trauma in the last 3 months; use of psychotropic medications; infectious diseases (tuberculosis, leprosy, HIV, systemic fungal diseases) or any other similar condition; severe underlying disease (heart, kidney, liver, lung) or malignancy; diabetes mellitus and decompensated hyperthyroidism; history of topical and aesthetic treatments in the last 3 months; glucose 6-phosphate deficiency; lack of ability or willingness to provide informed consent; lack of availability for visits or to comply with study procedures; hypersensitivity to ozone therapy treatment, climacteric or premature ovarian failure; pelvic pain complaints; use of oral or injectable hormonal contraceptives; progestogens	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-9pcztrb	Photobioduction therapy in leprosy lesions	Recruitment completed	Intervention	2023-07-06	<NULL>	<NULL>	6212	Biological effects produced by photobiomodulation in the repair of hypochromic leprosy spots	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9pcztrb	<NULL>	Clinical evidence of the disease and participation in the leprosy treatment and control program at the UBS; To be assisted at the Clínica Escola da Faculdade Guaraí; Being treated with specific multidrug therapy for Mycobacterium leprae; Age above 18 years, and in both sexes; Accepting to participate in the research through free and informed consent	Patients who have no records notified in the last year; Records that are erased; Cases such as diagnostic errors, even after notification; Discomfort during the application of the treatment; Cognitive impairment of understanding or important communication; Performing another treatment, other than the conventional one, for leprosy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-44msqcs	Randomized, crossover, placebo-controlled clinical trial to evaluate the effect and safety of sketamine in aiding the improvement of standard care for Post Traumatic Stress Disorder	Recruiting	Intervention	2023-07-05	<NULL>	<NULL>	6202	Randomized, Double-blind, Crossover, Placebo-controlled clinical trial to evaluate the efficacy and safety of Esketamine in augmentation of standard care for Post-Traumatic Stress Disorder	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-09-30	Universidade Federal da Bahia	Hospital Universitário Professor Edgard Santos	https://ensaiosclinicos.gov.br/rg/RBR-44msqcs	<NULL>	Male or female, eighteen to sixty-five years old. Level of understanding sufficient to agree to the necessary tests and exams and sign the Free and Informed Consent Form. Fulfill the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, for the diagnosis of post-traumatic stress disorder, from the structured diagnostic interview The Mini International Neuropsychiatric Interview. Initial score of at least fifty points on the Clinician-Administered Post Traumatic Stress Disorder Scale. A woman of childbearing age who agrees to use contraceptive methods or to commit to abstaining from sexual activity in order not to become pregnant during the study	Diagnosis of bipolar disorder and schizophrenia or any other psychotic disorder. Current diagnosis of bulimia or anorexia nervosa. Individuals with a history of alcohol or drug use disorder (other than nicotine or caffeine) within the last 3 months and must have a negative alcohol and drug test at screening. Women who are pregnant or breastfeeding. Serious and unstable clinical diseases. History of seizures without a clear and resolved etiology. Treatment with a monoamine oxidase inhibitor within 4 weeks prior to the study. Treatment with any other concomitant medication that may interfere with the outcome assessment or participant safety (benzodiazepines, scopolamine, antihistamines, psilocybin, methamphetamines, propranolol). In case of use of a benzodiazepine for the treatment of insomnia, the dose should be reduced, use a non-benzodiazepine hypnotic and wait three half-lives for entry into the study. Presence of any clinical disease that may alter the morphology and/or physiology of the brain. Clinically significant abnormal laboratory tests. Investigators or their immediate family members. Active suicide risk. Severe depression (score greater than 28 on the Montgomery-Asberg Depression Scale). Patients who, after randomization, need to change the standard treatment with drug withdrawal or inclusion of new ones in their treatment regimen for post-traumatic stress disorder should be excluded from the study to minimize potential biases caused by differences between groups. The last addition, change, or dose increase of antidepressant should be 30 days apart before randomization. Women of childbearing age who do not use contraceptive methods or do not abstain from sexual activity or become pregnant during the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-79h2ppx	Analysis of intestinal mucosa and fat nearby the intestine in patients with Crohn&apos;s disease	Data analysis completed	Observational	2023-07-05	<NULL>	<NULL>	6203	Transcriptional analysis of intestinal mucosa and mesenteric adipose tissue of patients with Crohn&apos;s disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2017-10-25	Hospital de Clínicas - Universidade Estadual de Campinas (UNICAMP)	Hospital de Clínicas - Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-79h2ppx	<NULL>	Patients with endoscopic and histological diagnosis of ileocecal Crohn&apos;s disease undergoing surgical procedure. For the control group of distal ileum, patients who underwent colonoscopy for other reasons, whose examination comes without endoscopic changes. For the control group of mesenteric adipose tissue (intestinal fat), patients with non inflammatory diseases of the left colon undergoing surgery, with normal terminal ileum. All survey participants are over 18 years of age	The patients participating in the control groups without the use of medication. And Crohn&apos;s patients with disease locations other than the small intestine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:12
RBR-59z6n59	Effects of two water-based exercise programs on health parameters in adults with Type 2 Diabetes	Recruiting	Intervention	2023-07-05	<NULL>	<NULL>	6204	Effects of different volumes of water-based combined training on health parameters in adults with Type 2 Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-59z6n59	<NULL>	Men and women with type 2 diabetes mellitus; aged between 40 and 65 years; who are undergoing medical treatment using oral hypoglycemic agents and/or insulin; who are not practicing systematic physical exercise in the three months prior to the study	Uncontrolled hypertension; autonomic neuropathy; severe peripheral neuropathy; proliferative diabetic retinopathy; severe non-proliferative diabetic retinopathy; uncompensated heart failure; peripheral amputations; chronic renal failure; body mass index (BMI) &gt; 45.0 kg/m2; individuals who experienced severe symptoms of COVID-19 in the previous 12 months (resulting in hospitalization); any muscle or joint impairment that prevents the performance of physical exercises safely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-6tmm9vp	Evaluate the effect of online physiotherapy on functionality, muscle strength and quality of life of patients with COVID-19 sequelae: a randomized clinical trial	Recruitment completed	Intervention	2023-07-05	<NULL>	<NULL>	6205	Effect of two telerehabilitation modalities on functionality, muscle strength and quality of life of COVID-19 survivors: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Secretaria Municipal de Saúde de Porto Alegre	Secretaria Municipal de Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6tmm9vp	<NULL>	Laboratory-confirmed SARS-2 infection, with a clinical diagnosis of COVID-19; having received hospital treatment and having been discharged from the hospital; presenting levels, 3, 4 or 5 of the Post-COVID-19 Functional Status Scale (PCFS); aged 18-100 years; both genders; ownership and ability to use a smartphone independently or with the support of family members; being a WhatsApp or Google Meet application user	As exclusion criteria: resting heart rate of more than 100 bpm measured at the initial visit; taking medications that can affect cardiopulmonary function and heart rate, such as trimetazidine, bronchodilators, or β-blockers; medical history of cerebrovascular or cardiac condition in the last 12 months, severe kidney disease, other serious organic disease, uncontrolled hypertension (rest BP≥160 / 100mmHg), uncontrolled diabetes; received intra-articular injection of drugs or surgical treatment of the lower extremities within the last 6 months; unable to walk independently with an assistive device; unable or unwilling to collaborate with assessments; enrolled or participated in other studies in the last 3 months; have a severe cognitive or mental disorder or a history of substance abuse; enrollment in any other rehabilitation program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-3npywr6	Zirconia implants installed in maxillas and mandibles with one or more missing teeth	Recruiting	Observational	2023-07-05	<NULL>	<NULL>	6206	Longitudinal follow up of immediate and mediate zirconia implants in partial and total edentulous mandible and maxilla regions	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3npywr6	<NULL>	male and female volunteers aged at least 18 years healthy or with systemic diseases	Pregnant or systemic patients who are not being treated	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-9rnxgfk	Effectiveness of a Physiotherapeutic Protocol of Lung and Muscle Exercises in elderly individuals who stay at home and have difficulty walking	Recruitment completed	Intervention	2023-07-05	<NULL>	<NULL>	6207	Effectiveness of a Physiotherapeutic Protocol of Cardiorespiratory and Motor Exercises in elderly individuals living with reduced mobility	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-12	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-9rnxgfk	<NULL>	Individuals aged 65 or over; of both sexes; restricted to their home; have low mobility	Individuals with a surgical procedure less than 60 days; Short Physical Performance Battery level A; not accepting to participate in the study; present cognitive alteration; perform private or public physiotherapy within the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-8fnb6xx	Clinical Trial for the Evaluation of the Safety of the Product in Study Cream Gel through the Evaluation of Skin Compatibility under Normal Conditions of Use	Recruitment completed	Observational	2023-07-05	<NULL>	<NULL>	6208	Clinical Trial to Assess the Safety of the Research Product Cream Gel through Evaluation of Cutaneous Acceptability under Normal Conditions of Use	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-01	Kosmosciense Ciência e Tecnologia Cosm Imp Exp Ltda	Kosmosciense Ciência e Tecnologia Cosm Imp Exp Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8fnb6xx	<NULL>	Age group between 18 and 70 years old. Female or male sex. Phototype (Fitzpatrick): I to VI. Have intact skin in the application region. Agree to adhere to the study procedures and requirements: study time, returns (after 21 days) to the laboratory to carry out the study procedures, home use of the product under investigation, filling in the use diary, not changing habits during the period of the study.  Agree to adhere to the requirements of the study in combating the COVID-19 pandemic, through preventive measures: use a mask in accordance with WHO guidelines, use the mask while traveling to the research center and during study procedures, maintain social distancing, wash your hands frequently with soap and/or alcohol gel and attend the research center only at scheduled times to avoid crowds	Pregnant or breastfeeding women, Participant who belongs to the risk group for COVID-19, that is, with chronic cardiovascular, renal and respiratory problems, immunosuppressed or other conditions that the investigator judges as belonging to the risk group, Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular, malformations, scars, increased hairiness, freckles and warts in large numbers, sunburn), Presence of dermatoses or active skin lesions (local and/or disseminated) in the study region. History of ineffectiveness, allergic reactions, irritation or feeling of intense discomfort to topical products. Prediction of vaccination during the study or up to 3 weeks before the study. History of pathologies aggravated or triggered by ultraviolet radiation. Use of non-steroidal anti-inflammatory drugs, corticoids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study.  Aesthetic or dermatological body treatment up to 4 weeks before the study. Hormonal treatments not stable in the last 3 months, if applicable. Hyperpigmentation associated with the use of drugs such as tetracycline, phenothiazides or amiodarone. Hyperpigmentation associated with photosensitivity. Actinic lichen planus. People directly involved in carrying out this study and their family members. Participating in another study. History of non-adherence or unwillingness to adhere to the study protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-74b44vf	Assessment of Primary and Accumulated Irritation Potential, Skin Sensitization Potential and Skin Allergy and Toxicity Potential by Ultraviolet Light Accompanied by a Dermatologist for the Gel Cream Product	Recruitment completed	Observational	2023-07-05	<NULL>	<NULL>	6209	Assessment of Primary and Accumulated Irritation Potential, Skin Sensitization Potential and Skin Photoallergy and Phototoxicity Potential Supervised by Dermatologist for the Cream-Gel Product	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-05-25	Kosmosciense Ciência e Tecnologia Cosm Imp Exp Ltda	Kosmosciense Ciência e Tecnologia Cosm Imp Exp Ltda	https://ensaiosclinicos.gov.br/rg/RBR-74b44vf	<NULL>	Healthy research participant. Age range between 18 and 70 years. Gender: female and male. Phototype (Fitzpatrick): I to IV. Agree to adhere to the requirements of the study in combating the COVID-19 pandemic, through preventive measures: use a mask according to WHO guidelines, use the mask when traveling to the research center and during the study procedures, maintain the social distancing; wash your hands frequently with soap and/or alcohol gel and attend the research center only at scheduled times to avoid crowds. Agreement not to wet the site during the entire test period. Understand the test procedures and agree to adhere to the study requirements. Absence of inflammatory dermatosis or tattooing at the application site. Signature of the Free and Informed Consent Term (TCLE)	Pregnancy, lactation. Participant who belongs to the risk group for COVID-19, that is, with chronic cardiovascular, kidney and respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group. Use of corticosteroids, antihistamines and/or anti-inflammatories. History of allergy to cosmetic products and/or health products. Presence of localized or generalized dermatological diseases. Presence of active inflammatory dermatoses in the test region. Presence of nevic lesions in the test region. Personal or family history of skin cancer. Use of topical or systemic photosensitizing medication. History of phototoxic or photoallergic reactions. Photo-induced pathologies, such as Lupus Erythematosus, Recurrent Herpes Simplex, History of dermatoses caused by light, such as solar urticaria and polymorphous light eruption. Frequent exposure to the sun or tanning beds. Have participated in an allergenicity study within a period of less than four weeks from the beginning of the study. Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevi in large numbers, sunburn). Active dermatoses (local or disseminated) that may interfere with the study results. History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics, health products or medicines. Research participants with a history of allergy to the material used in the study. Background of atopy. History of pathologies aggravated or triggered by ultraviolet radiation. Immunodeficiency patients. Intense sun exposure or tanning session up to 15 days before the initial assessment. Prediction of intense sun exposure or tanning session during the study period. Provision of bathing in the sea, swimming pool or sauna during the study. Research participants who practice water sports. Dermographism. Use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to 2 weeks before selection. Treatment with acidic vitamin A and/or its derivatives orally or topically up to 01 month before the start of the study. Body aesthetic and/or dermatological treatment up to 03 weeks before selection. Prediction of vaccination during the study or up to 03 weeks before the study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study. History of non-compliance or unwillingness to adhere to the study protocol. Professionals directly involved in carrying out this protocol and their families. Be participating in some other study at the time. Any condition that, in the opinion of the researcher, could compromise the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-239fmgx	Oya Care protocol for management of the health of patients with ovaries	Not yet recruiting	Observational	2023-07-04	<NULL>	<NULL>	6198	Oya Care protocol for healthcare of patients with ovaries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-07-23	Fundação do ABC - Faculdade de Medicina do ABC	Fundação do ABC - Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-239fmgx	<NULL>	Patients with ovaries; patients aged at least 18 years; patients of any race, skin color and ethnics; patients of any sexual orientation; patients of any gender identity; patients of any social status; patients of any social group	Patients aged less than 18 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-6r3q4zn	Effects of home Exercise Technology for the elderly	Not yet recruiting	Intervention	2023-07-04	<NULL>	<NULL>	6199	Development and Evaluation of Home Exercise Technology for the elderly: Heeh Project	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-05	Universidade de Brasília	Secretaria de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-6r3q4zn	<NULL>	Both sexes; age between 60 and 80 years; be registered and monitored at the Ambulatory; own or have relatives in the same household who have a smartphone that supports the application with internet access; be available to attend the monthly consultations carried out throughout the study; being independent in activities of daily living, through the Barthel index; non-practitioners of physical activity or insufficient physical activity, assessed using the International physical activity questionnaire (IPAQ), an instrument that assesses the level of physical activity	Age greater than 80 years; chronic complications of DM (neuropathy; nephropathy, retinopathy, limb amputation and diabetic foot); participate in another clinical trial, research study, or exercise program where they perform similar balance and strength activities; having mobility limitations or using walking devices; diagnosis of progressive neurological disease or other acute or unstable medical condition that precludes performing the exercises; make use of medications that interfere with balance; failing to perform any evaluation proposed in the study protocol; presenting cognitive impairments assessed through the Mini Mental State Examination (MMSE) - the cutoff scores used for exclusion will be: 17 for illiterates; 22 for seniors with between 1 and 4 years of schooling; 24 for those with between 5 and 8 years of schooling and 26 for those with 9 or more years of schooling; and those with mobility deficits – Timed Up-and-Go (TUG) over 20 seconds, a timed test that assesses walking speed, balance and risk of falling	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-942kk6s	Effect of strengthening the inspiratory muscles in patients after cardiac surgery	Data analysis completed	Intervention	2023-07-04	<NULL>	<NULL>	6200	Inspiratory muscle training in the postoperative period of cardiac surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-09-01	Faculdade de Medicina do ABC	Hospital do Coração do Cariri - HCC	https://ensaiosclinicos.gov.br/rg/RBR-942kk6s	<NULL>	Patients in the postoperative period of elective cardiac surgery via sternotomy and using cardiopulmonary bypass; left ventricular ejection fraction above 40%; body mass index lower than 30 kg/m2.	Patients who required additional surgery during the postoperative period; as well as those who had complications such as cardiorespiratory arrest;  prolonged sedation; mechanical ventilation time greater than twenty-four hours;  neurological complications; patients who could not understand or collaborate with the procedures were also excluded since the conducts applied in the  inspiratory muscle training are volitional.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-8v4p3rs	Teaching and learning emergency scenarios through Realistic Simulation	Recruiting	Intervention	2023-07-04	<NULL>	<NULL>	6201	Realistic Simulation in the Teaching and Learning Process in Urgency and Emergency	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-15	Universidade Estadual de Londrina	Hospital Doutor Eulalino Ignácio De Andrade	https://ensaiosclinicos.gov.br/rg/RBR-8v4p3rs	<NULL>	Graduation in nursing completed; with no minimum time of academic training; Nurses on vacation or leave will also be invited.	Do not contemplate all phases of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-58tvk8s	Selective Insufflation and Ventilatory Transfer in neonatal lung expansion	Recruitment completed	Intervention	2023-07-03	<NULL>	<NULL>	6193	Selective Insufflation and Ventilatory Transfer in neonatal lung expansion: an interventional, randomized, controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-58tvk8s	<NULL>	Newborns admitted to the neonatal intensive care unit of the Complexo Hospital de Clínicas de Curitiba - Paraná; with areas of hypoventilation or pulmonary atelectasis; whose guardians consent to the participation and sign the Informed Consent Form and/or Informed Consent Form	Atelectasis of the left hemithorax caused by malposition of the endotracheal cannula; chest malformation; presence of a chest drain; active pulmonary hemorrhage; severe pulmonary hypertension; hemodynamic instability when using vasoactive drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:09
RBR-10kxn5rs	Effectiveness of the Pikluc® to relieve pain of intramuscular injection in children and adolescents	Not yet recruiting	Intervention	2023-07-03	<NULL>	<NULL>	6194	Effectiveness of the Pikluc® Device for pain relief associated with intramuscular injections in children and adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-10kxn5rs	<NULL>	Medical indication for intramuscular injection, in the right or left ventro-gluteal region or right or left deltoid region; to have the possibility of body weighing and height measurement; to be aged between 4 and 15 years; both genders	Cognitive deficit; psychiatric disorders; diseases that felt sensitivity to pain; having ingested substances that affect sensitivity to pain; people who underwent invasive procedures on the same day as the intramuscular injection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-33nfry3	Evaluation of the left atrium during stress echocardiography for the diagnosis of Ischemic Heart Disease	Recruiting	Observational	2023-07-03	<NULL>	<NULL>	6195	Left atrial strain during stress echocardiography for the assessment of Myocardial Ischemia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-02-01	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-33nfry3	<NULL>	Patients undergoing stress echocardiography for assessing Myocardial Ischemia due to chest pain or dyspnea; both genders; age between 18-80 years old; Left ventricular ejection fraction greater than 50%	Patient refusal; limitations for assessing left ventricular function by echocardiography; left ventricular ejection fraction less then 50%; prosthetic valves or valve disease graded as moderate or severe; atrial fibrillation; allergy or abnormal reaction to dobutamine; exclusion criteria for the use of atropine during dobutamine stress echocardiography are glaucoma and obstructive prostatic disease, in which case only dobutamine is used as a pharmacological stressor	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-10d3bt7g	Use of Red Propolis from Alagoas for the treatment of injuries resulting from the treatment of oral cancer	Recruiting	Intervention	2023-07-03	<NULL>	<NULL>	6196	Oral cancer: early diagnosis and care for injuries resulting from cancer treatment using technological products based on Red Propolis from Alagoas	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-15	Centro de Estudos Superiores de Maceió-CESMAC	Centro de Estudos Superiores de Maceió-CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-10d3bt7g	<NULL>	Participants of both sexes; aged between 18 and 64 years; under antineoplastic treatment; with oral and oropharyngeal cancer that fits into at least one of the following International Disease Classifications - ICD C01, C02, C03, C04, C05, C06, C07, C08, C09 or C10	Research participants with intellectual or non-collaborative difficulties that may hinder the use of the propolis-based orodispersible film and participation in complementary exams; pregnant research participants, as there is not enough evidence on the safe use of low power laser and red propolis from Alagoas for this group; research participants who present with severe immunosuppression and inability to leave the hospital environment because they are not responsive to the therapies used in the study; participants who refuse to sign the TCLE and participants who are allergic to film components (propolis and Crustaceans)]	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-4vhnyr9	Hypopressive Abdominal Gymnastics Protocol to reduce Diastasis of the rectus abdominis muscles after cesarean delivery in the remote period	Recruiting	Intervention	2023-06-30	<NULL>	<NULL>	6189	Hypopressive Abdominal Gymnastics Protocol for reducing Diastasis of the abdominal rect muscles in Puerper women after caesarean delivery in the remote period	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4vhnyr9	<NULL>	Women; age over 18 years; cesarean section; primiparous; between 45 days and 6 months postpartum; single pregnancy; distance between rectus abdominis (DIR) greater than 3 cm; able to perform the hypopressive maneuver for the IG	Women who are undergoing pregnancy; who have neurological or autoimmune tissue disorders; contraindications for hypopressive abdominal gymnastics (cardiorespiratory disease, systemic arterial hypertension, cancer, vasovagal disorders); who have performed hypopressive abdominal gymnastics in the last 2 years; who are performing any intense physical exercise; who are undergoing physiotherapeutic treatment for postpartum follow-up of abdominal dysfunction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-6w9v53s	Effect of Laser therapy in the prevention of post-procedure pain in patients with toothache	Terminated	Intervention	2023-06-30	<NULL>	<NULL>	6190	Effect of laser therapy on the prevention of postoperative pain in cases of endodontic urgency: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-08	Centro Educacional Universitário do Maranhão - CEUMA	Centro Educacional Universitário do Maranhão - CEUMA	https://ensaiosclinicos.gov.br/rg/RBR-6w9v53s	<NULL>	Patients aged between 18 and 50 years; both genders; with posterior teeth diagnosed with symptomatic irreversible pulpitis and coronary structure capable of receiving absolute isolation	Pregnant patients, patient with systemic disease that contraindicates endodontic treatment, including recent myocardial infarction, uncontrolled hypertension and uncontrolled diabetes; patient with ingestion of any type of analgesic / anti-inflammatory medication before treatment, patients with allergy to articaine, tooth with internal and external resorption, tooth with periodontal disease, lack of patient cooperation, patient with intolerance to non-inflammatory drugs steroids, teeth in orthodontic movement and teeth with anatomical changes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-26vvm7s	The combined effect of immersive virtual reality techniques and noninvasive brain stimulation on movement speed in healthy individuals	Recruiting	Intervention	2023-06-30	<NULL>	<NULL>	6191	Effect of the combination of Immersive Virtual Reality (RVI) and Transcranial Direct Current Stimulation (TDCS) on motor response in healthy individuals	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Universidade Presbiteriana Mackenzie	Universidade Presbiteriana Mackenzie	https://ensaiosclinicos.gov.br/rg/RBR-26vvm7s	<NULL>	Healthy participants; both sexes;  aged from 18 years to 40 years; right-handed	Diseases that decreased the functionality of the upper limb, such as orthopedic surgeries, advanced arthritis, deformities, joint block, neurological diseases; cardiac pacemaker; any neurosurgery with the use of metal implantation in the brain; chemical dependents; pregnancy or nursing women; cognitive impairment or who cannot understand the activities of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-8x8pf6d	3D digital analysis of dental arches before and after surgery in patients with unilateral and bilateral cleft lip and palate	Data analysis completed	Observational	2023-06-30	<NULL>	<NULL>	6192	Use of 3D Sterephotogrammetry for volumetric analysis and image superimposition of the dental arches before and after surgeries in patients with unilateral and bilateral cleft lip and palate	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-08-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8x8pf6d	<NULL>	Participants with non-syndromic unilateral cleft lip and palate; all surgical procedures were performed by a single plastic surgeon; male and female genders	Poor quality dental models	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-5ry9tn5	The use of Fat Grafting in the Treatment of Keloid: Randomized Clinical Trial	Recruiting	Intervention	2023-06-29	<NULL>	<NULL>	6185	Fat Grafting in the Treatment of Keloid: Randomized Clinical Trial (CONSORT)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-08	Universidade Federal de São Paulo - Unifesp	Universidade Federal de São Paulo - Unifesp	https://ensaiosclinicos.gov.br/rg/RBR-5ry9tn5	<NULL>	We will include patients between the ages of 18 and 50; of both sexes; with keloids on the anterior thoracic region; without specific treatment in the last six months; and with at least 12 months of evolution	Patients with more than one keloid in the anterior thoracic region; with specific treatment for less than six months; patients with collagen diseases; malignant neoplasms of any etiology; current topical or systemic use of corticosteroids and chemotherapy; pregnant and lactating women; patients who do not complete any of the stages proposed by the present study; patients who willingly withdraw their voluntary participation, without any prejudice to their treatment and medical follow-up, will not be included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-7r2m8c4	Efficacy of low-level laser therapy used as an adjunct to basic periodontal therapy	Recruiting	Intervention	2023-06-29	<NULL>	<NULL>	6186	Efficacy of photobiomodulation as an adjunct to non-surgical periodontal treatment in patients with periodontitis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-30	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7r2m8c4	<NULL>	Individuals aged 18 years or older. Both genders. With periodontitis at any stage or degree. Must have suffered attachment loss at two or more non-adjacent interproximal sites. Must have at least three periodontal sites in different quadrants with probing depth - PD equal to or greater than 4 mm, clinical attachment loss (CAL) of 1 mm or more. Bleeding on probing - BOP	Pregnant or lactating individuals. Smokers and individuals who quit smoking within the last five years. Diabetic patients. Individuals who underwent periodontal treatment in the six months prior to the study. Individuals who received antibiotic therapy in the three months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-7mzjqv4	Aerobic exercise and mood states	Data analysis completed	Intervention	2023-06-29	<NULL>	<NULL>	6187	Effects of different intensities of physical exercise on the quinurenine pathway and mood states	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7mzjqv4	<NULL>	Male gender. Aged between 20 and 35 years. Have a training routine with a minimum frequency of 3x/week, for a minimum period of one year. Be considered physically active by the International Physical Activity Questionnaire - IPAQ. Not present any type of psychological or eating disorder. Not chronically on medication. Need to be considered in good health after cardiological evaluation. Cannot have undergone surgery in the last 6 months. Cannot have any physical, muscular and/or joint problems	Inability to comply with the entire experimental protocol for any reason. Non-attendance at the stipulated times between tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-3wshg2m	Evaluation of vaccine response to 13-valent pneumococcal conjugate vaccine and 23-valent polysaccharide vaccine in patients living with HIV/AIDS	Recruiting	Intervention	2023-06-29	<NULL>	<NULL>	6188	Analysis of humoral and cellular immune responses to 13-valent pneumococcal conjugate vaccine and 23-valent polysaccharide vaccine in patients living with HIV/AIDS	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2023-04-28	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Serviço de Atendimento Especializado Carlos Cruz	https://ensaiosclinicos.gov.br/rg/RBR-3wshg2m	<NULL>	HIV-infected patients confirmed by confirmatory tests (Western-Blott and/or HIV polymerase chain reaction viral load) who are of any gender identity. Being in regular use of highly effective antiretroviral, according to the definitions of the Ministry of Health, for at least four weeks. Minimum age 18 years old. Signature of the Free and Informed Consent Form (Appendix A) . For the control group: negative quick test for HIV	Patient with a history of anaphylactic reaction to pneumococcal conjugate vaccines (PCV-7, PCV-10 or PCV-13) or 23-valent pneumococcal polysaccharide vacines. Previous vaccination with PCV-7, PCV-10, PCV-13 (interference in the evaluation of the pre-vaccination humoral immune response). Have been vaccinated with PPV-23 less than 1 year ago. Transfusion of blood components or Immunoglobulins in the last 28 days before vaccination with PCV-13 or PPV-23. Blood dyscrasias that prevent intramuscular vaccine application; Fever in the last 24 hours before vaccination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-2zdn8pb	Hip Anesthesia in elderly  with Hip Fractures admitted to the emergency department	Recruitment completed	Intervention	2023-06-28	<NULL>	<NULL>	6180	Ultrasound-Guided Hip Pericapsular Block in elderly  with Proximal Femur Fractures admitted to a public emergency hospital	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-12-18	Gustavo Martins Fontes	Faculdade de Ciencias Médicas da Santa Casa de Misericórdia de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2zdn8pb	<NULL>	Patients aged 65 years or older, regardless of gender, diagnosed radiographically with an acute and displaced hip fracture. For femoral neck fractures, based on the Garden classification, we included types III and IV. For transtrochanteric fractures, classified by Tronzo, types III to V were selected) Inclusion criteria are also ASA II and III.	"Under 65 years old, ASA I, with fractures without displacement to the femoral neck based on the Garden classification (Garden Types I and II) and transtrochanteric fractures without displacement, based on the Tronzo classification (Tronzo I and II).
Patients with subtrochanteric, diaphyseal or distal femoral fractures, those with association with other fractures, pathological fractures, pseudarthrosis and previous conditions that limit hip flexion to 45 degrees will be excluded.
History of allergies or reactions reported to the anesthetic used in the block or that present skin lesions close to the puncture site that may contraindicate the procedure will also be excluded.
Patients with advanced renal or hepatic insufficiency, as well as those using anticoagulants at a therapeutic dose or clotting disorder prior to fracture.
Finally, patients unaccompanied by legal guardians were also excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-10b93fbz	Effectiveness of Percussive Massage using a portable device on muscle pain in amateur runners	Recruiting	Intervention	2023-06-28	<NULL>	<NULL>	6181	Effectiveness of Percussive Massage using a portable device on muscle pain in recreational runners: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10b93fbz	<NULL>	Age from 18 to 59 years; both sexes; running for at least two months; able to cover a distance of ten kilometers without interruption	Self-report of musculoskeletal pain at the time of data collection; difference greater than 1.5 cm in the size of lower limbs; not complete the established distance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-59phz5c	Treatment of Diabetic Macular Edema with Intraocular Injection of Dexamethasone	Recruiting	Intervention	2023-06-28	<NULL>	<NULL>	6182	Treatment of Diabetic Macular Edema with Intravitreal Injection of Dexamethasone 2 mg/mL	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2023-05-23	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-59phz5c	<NULL>	age 18 or older; diagnosis of diabetes mellitus; presence of clinically significant bilateral diabetic macular edema; best corrected visual acuity between 20/400 and 20/40; central macular thickness  &gt;= 300 µm, measured by spectral domain optical coherence tomography.	Any treatment for diabetic macular edema in the past 4 months; Panretinal photocoagulation  within the past 4 months; Any eye surgery performed within the past 4 months; History of pars plano vitrectomy; History of open-angle glaucoma or corticosteroid-induced elevated intraocular pressure requiring ocular antiglaucoma or antihypertensive treatment; Intraocular pressure &gt;= 21 mmHg; History of allergy to any product used in the procedure; Presence of tractional retinal detachment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-6jmr68m	Clinical study of a Type of Vitamin E obtained from the annatto in the control of High Cholesterol	Recruitment completed	Intervention	2023-06-28	<NULL>	<NULL>	6183	Clinical study of a Formulation Containing 70% Tocotrienol, obtained from annatto, in the control of Lipidemias	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-15	Hospital das Clínicas da Universidade Estadual de Campinas	New Max Industrial Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-6jmr68m	<NULL>	People aged from 18 years to 75 years; both sexes; with dyslipidemia, characterized by serum levels of Low Density Lipoprotein above 100mg/dL and who are not allergic to annatto or traces of annatto	People with psychiatric disease or other disease that affects the understanding of the consent term; Women who are pregnant or breastfeeding; People with allergy to Urucum; People to whom specific drug is being administered to control high levels of triglycerides; people with comorbidities, including diabetes, cardiovascular disease,  several renal failure, hepatitis;active infeccion  and participants who make a change in lifestyle that impacts the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-3ksnxkm	Comparative Study between Transcranial Direct Current Stimulation and Binaural Vibro-Acoustic Brain Stimulation in Parkinson&apos;s	Recruiting	Intervention	2023-06-28	<NULL>	<NULL>	6184	Comparative study between transcranial direct current stimulation and binaural vibro-acoustic brain stimulation in Parkinson&apos;s patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Hospital Universitário Onofre Lopes	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-3ksnxkm	<NULL>	Have a diagnosis of Parkinson&apos;s Disease; in stage 2 or 3 of the disease; both genders; being between 55 and 70 years old; with independent gait	Make use of Deep Brain Stimulation; make use of cochlear implants; having uncontrolled labyrinthitis; having uncontrolled hypertension	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-6x5vrsr	Evaluation of the bacterial community and proteins present in the skin region around extraoral implants in different clinical conditions	Recruitment completed	Observational	2023-06-27	<NULL>	<NULL>	6179	"Microbiological and proteomic profile in the transcutaneous region of extraoral implants in 
 different clinical conditions"	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-05-07	Associação Unificada Paulista de Ensino Renovado Objetivo	Coordenação de aperfeiçoamento de pessoal de nível superior	https://ensaiosclinicos.gov.br/rg/RBR-6x5vrsr	<NULL>	Patients with implant-supported oculopalpebral prostheses with 2 extraoral implants for prosthetic retention; have agree to TCLE	Have no tumor recurrence; have 180 days without the use of antibiotic therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-8gsjbmr	Factors indicative of the success of a multimodal treatment consisting of Manual Therapy, Exercises and Pain Education in individuals with Mandibular joint problems	Recruitment completed	Intervention	2023-06-27	<NULL>	<NULL>	8018	Success predictive factors of a multimodal treatment consisting of Manual Therapy, Therapeutic Exercises and Pain Education in individuals with Temporomandibular Disorders	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Faculdade de Medicina de Ribeirão Preto	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-8gsjbmr	<NULL>	Individuals diagnosed with Temporomandibular disorders, according to the Brazilian version of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD); aged between 18 and 40 years; of both sexes	Edentulous individuals who do not use dentures; with a history of systemic diseases; neurological disorders; a history of trauma or head or neck surgery less than one year ago; which have received orofacial treatment in the last six months; are unable to cooperate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-2dqd733	Effect of ozone gel on pain, swelling and limitation of mouth opening after wisdom tooth extractions in the same patient, one side using the gel and the other not	Not yet recruiting	Intervention	2023-06-26	<NULL>	<NULL>	6176	Effect of ozonized gel on the control of pain, edema and trismus in patients undergoing mandibular third molar extractions: a randomized split-mouth clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-21	Faculdade de Ciências da Saúde da Universidade de Brasília - UnB	Faculdade de Ciências da Saúde da Universidade de Brasília - UnB	https://ensaiosclinicos.gov.br/rg/RBR-2dqd733	<NULL>	Volunteers of both sexes; age between 18 and 30 years; healthy; do not use any medication; having (radiographically evaluated) the two lower third molars in position B and class II of the Pell &amp; Gregory Classification	Volunteer with systemic disease; pregnant; lactating woman; smoker; patient with an infectious process or tumor; person who presents incompatibility with standardized medication; patient who has and wishes to extract upper third molars (provided they are indicated) in the same surgical intervention; patient who wants to extract both lower third molars in the same session	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-10qh48qj	Effect of the combination of platelet-rich fibrin with deproteinized bovine bone on bone formation after pre-radiotherapy tooth extraction in head and neck cancer patients	Not yet recruiting	Intervention	2023-06-26	<NULL>	<NULL>	6177	Effect of combined PRF with deproteinized bovine bone on bone formation after pre-radiotherapy tooth extraction in head and neck cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-10	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10qh48qj	<NULL>	Patients diagnosed with head and neck cancer; both genders; age above 18 years; with indication and need for pre-radiotherapy tooth extraction and who provide consent to participate in this research project by signing the free and informed consent form	Minor patients; patients who do not agree with the free and informed consent form; patients with advanced tumors who, due to the urgency of starting radiotherapy, do not have enough time to perform tooth extractions; patients with health alterations that contraindicate surgical procedures for tooth extraction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-2tx7m8v	Effect of millet consumption on metabolic responses responses in adult subjects	Recruitment completed	Intervention	2023-06-26	<NULL>	<NULL>	6178	Effect of millet (Pennisetum glaucum (L.) R. Br.) consumption on metabolic responses responses in adult subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade Federal de Viçosa - Departamento de Nutrição e Saúde	Embrapa Agroindústria de Alimentos	https://ensaiosclinicos.gov.br/rg/RBR-2tx7m8v	<NULL>	Have normal blood glucose levels (fasting capillary glucose ranging from 70 to 99 mg/dL); regular breakfast intake; have a Body Mass Index (BMI) between 18.5 and 24.9 kg/m² and a body fat percentage between 20 and 30% for females and between 12 and 20% for males;  are between 18 and 60 years old; engage in light physical activity	Smokers; alcohol consumption exceeding 2 drinks per day (&gt; 50g of ethanol/day); presence of type 1 or type 2 diabetes or prediabetes (fasting blood glucose between 100 and 125 mg/dL); first-degree family history of diabetes mellitus; use of medications that affect blood glucose, energy metabolism, or appetite; use of medications, herbs, or diets for appetite and weight reduction; weight instability (gain or loss of approximately 3 kg in the 3 months prior to the start of the study); recent change in level of physical activity; aversion or intolerance to the foods provided in the study; presence or history of digestive, hepatic, renal, cardiovascular, thyroid, or recent inflammatory diseases; diagnosis of cancer in the previous year; history of eating disorders; and being pregnant or lactating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-4nvxt7x	N-Acetyl Cysteine ​​Injection in knee and hip for Arthrosis treatment	Recruiting	Intervention	2023-06-23	<NULL>	<NULL>	6173	N-Acetyl Cysteine Joint Infiltration ​​in the treatment of hip and knee Osteoarthritis	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-06-05	Santa Casa de Misericórdia de Belo Horizonte - Ensino e Pesquisa	Santa Casa de Misericórdia de Belo Horizonte - Ensino e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-4nvxt7x	<NULL>	"Patients of both sexes; no age limits; symptomatic knee osteoarthritis for more than 6 months and
with access to physical therapy"	Patients with a history of joint surgeries; use of dual antidepressants up to 60 days before the initial assessment; regular use of therapeutic or prophylactic anticoagulants; use of gabapentinoids up to 60 days before the initial evaluation; use of oral or intramuscular corticosteroid therapy up to 60 days before the assessment; previous joint infiltration up to 12 months before the initial evaluation; neurological deficits; disabling systemic disease; chemical immunosuppression or secondary to microbiological agents; use of antirheumatic agents; active infectious conditions; past history of joint infection; diabetes mellitus and glycated hemoglobin greater than 7.0% in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-8wdrwhs	Do the characteristics of the Bite-Stabilizing Plate change depending on how it is printed?	Not yet recruiting	Intervention	2023-06-23	<NULL>	<NULL>	6174	Prosthetic properties of the Interocclusal Stabilizing Device, do they change according to the impression angle? A randomized crossover blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Uberlândia - Faculdade de Odontologia	Universidade Federal de Uberlândia - Faculdade de Odontologia	https://ensaiosclinicos.gov.br/rg/RBR-8wdrwhs	<NULL>	Patients with a probable diagnosis of Sleep Bruxism (SB); with discomfort in the masticatory muscles; apparent hypertrophy of the masseter; history of teeth grinding during the night; healthy oral mucosa, absence of systemic diseases; the autonomy of behavior and expression; both genders; over 18 years old	Patients diagnosed with moderate and severe Obstructive Sleep Apnea; absence of one or more molars; patients with upper removable dental prostheses; patients undergoing orthodontic treatment; patients with neurological disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-86rj26s	The effect of physiotherapeutic assistance on the first delivery of high-risk pregnant women: a randomized clinical trial	Not yet recruiting	Intervention	2023-06-23	<NULL>	<NULL>	6504	Effectiveness of phisiotherapy assistance in the induced labor of high-risk primiparous: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-30	Departamento de Fisioterapia - Universidade Federal de Pernambuco	Centro de Parto Normal e Alojamento Conjunto - Hospital da Mulher do Recife	https://ensaiosclinicos.gov.br/rg/RBR-86rj26s	<NULL>	Primiparous women; labor induction with misoprostol 25mcg, vaginally; gestational age between 37 and 42 weeks, confirmed by the date of the last menses and/or by the most recent obstetric ultrasound; presence of a single, live fetus with cephalic presentation	Women with difficulty understanding verbal commands; identification of obstetric factors during hospitalization that suggest failure of induction or indication for cesarean section: fetal cardiotocography not tranquilizer/acute fetal distress, severe pre-eclampsia with blood pressure spikes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-2p9j8sn	Sensory and pain evaluation after surgical removal of the labial frenulum conventionally or with surgical diode laser	Recruiting	Intervention	2023-06-22	<NULL>	<NULL>	6169	Sensory and pain evaluation after Conventional Frenectomy or with Surgical Laser	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2p9j8sn	<NULL>	Healthy volunteers; both genders; non smokers; age between 13 and 70 years; with indication for upper and lower labial frenectomy	Patients with systemic disesases that impair oral surgery; smokers; pregnant women; alcoholic	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-10gnqvvd	Evaluation of the impact of acute nasal obstruction on sleep in healthy adults without previous nasal complaints, through an exam that evaluates breathing during sleep	Recruitment completed	Observational	2023-06-22	<NULL>	<NULL>	6170	Evaluation of the impact of acute nasal obstruction on the sleep of healthy adults without previous nasal complaints, through polysomnographic examination	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-01	Hospital da Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital da Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10gnqvvd	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 60 years; weight within the variation limit of 15% of the weight considered normal for men and women, taking into account height and physical structure;No complaints of nasal obstruction or obstructive anatomical alterations of the nasal cavity	Volunteers who had upper airway infection, allergic or non-allergic rhinitis, anatomical alteration that caused partial or total nasal obstruction in the airway higher; Volunteers using medications with action on the Central Nervous System; Volunteers with neuromuscular diseases. Volunteers with uncontrolled chronic diseases. Volunteers who are obese, have heart disease or have chronic obstructive pulmonary disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-85qq6jc	The effect of a new Pleural Drainage System in thoracic surgery	Data analysis completed	Intervention	2023-06-22	<NULL>	<NULL>	6171	Evaluation of the effectiveness of the Sinapi Pleural Drainage System in thoracic surgery	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-02	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-85qq6jc	<NULL>	Both genders; aged between 18 and 90 years; undergoing some type of partial lung resection	Pneumonectmy; joint wall resection; empyema on the same side of the surgery; VEF1 ppo (forced expiratory volume in one second predicted for the postoperative period) less than 40%	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-3vymq2j	The practice of Virtual physical exercise to work on physical, cognitive and psychological conditions in the elderly	Data analysis completed	Intervention	2023-06-22	<NULL>	<NULL>	6172	Intervention by Virtual physical exercise in physical, cognitive and psychological capacities in the elderly	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-11	Faculdade de Ciências Medicas - UNICAMP	Faculdade de Ciências Medicas - UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-3vymq2j	<NULL>	Be aged 70 years or older;  both genders; practitioners of physical exercise; obtain a score higher than the 25-point cutoff point of the Mini Mental State Examination	The individual cannot have previous diagnoses of diseases or serious physical and mental deficits which prevent participation in the research stages	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-7jc7btr	Assessment of skin irritability after using a health product responsible for reinforcing the skin&apos;s protection barrier, preventing microorganisms that cause skin diseases	Not yet recruiting	Intervention	2023-06-22	<NULL>	<NULL>	6428	Assessment of primary dermal irritability, cumulative dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-10-09	Medicin Instituto da Pele Ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7jc7btr	<NULL>	Participants of both sexes aged 18 to 70* years; Phototype: I, II, III and IV (according to an adapted scale); Skin of the application region is intact; Agreeing to follow the trial procedures and attend the clinic on the days and times determined for medical evaluations and for applying and reading swabs; Understanding, consent and signature of the Free and Informed Consent Term	Participants who have been diagnosed with COVID 19 in the last 4 weeks or who are experiencing symptoms such as fever, dry cough, tiredness, body aches or other discomforts; Pregnancy or risk of pregnancy and/or lactation (when women); Use of anti-inflammatory drugs 30 days and/or immunosuppressants for up to three months before selection; Immunosuppression by drugs or active diseases; Decompensated endocrinopathies; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; Expect intense exposure to sunlight or tanning sessions during the study period; Provision of bathing in the sea, swimming pool or sauna during the study; Practice of water sports during the study; Dermographism; Use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; Aesthetic and/or dermatological treatment on the body within 03 weeks prior to selection; Scheduled vaccination during the study period or up to 03 weeks before selection; History of sensitization, irritation or photosensitivity to topical products; Active skin pathologies (local and/or disseminated) that may interfere with the study results; Skin reactivity; Use of new drugs/cosmetics during the study; Previous participation in studies with the same product; Congenital or acquired immunodeficiency; Relevant medical history or current evidence of alcohol or other drug abuse; History of known or suspected intolerance to any ingredient of the study product (test or comparative product); History of non-adherence or unwillingness to adhere to the study protocol; Employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; Other conditions considered by the researcher as reasonable for disqualification from participation in the study. If yes, it should be described in observation in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-6td87pq	Minimum Effective Volume of local anesthetic for Ultrasound-guided PENG Block.	Not yet recruiting	Intervention	2023-06-21	<NULL>	<NULL>	6167	Minimum Effective Volume for Ultrasound-guided PENG Block	<NULL>	n/a, single-arm-study, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6td87pq	<NULL>	Patients with chronic hip pain, defined as pain for more than 3 months, and with indication for hip joint arthroplasty due to osteoarthritis.	Patients allergic to local anesthetics or the contrast agent used. Patients addicted to alcohol or illicit drugs. Weight &lt; 50 kg. Morbid obesity defined as body mass index (BMI) &gt; 40 kg/m2. Pregnant women. Patients with previous sensory alterations in dermatome of femoral or obturator nerves. Patients with cognitive impairment who are incapable of understanding the study and signing the informed consent form. Patients with skin infection at the puncture site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-3qyt32y	Compare the effects of Force Removal Maneuvers on Ventilatory Mechanics	Recruitment completed	Intervention	2023-06-21	<NULL>	<NULL>	6168	Comparative analysis of the effects of Higien Maneuvers Bronchial in Ventilatory Mechanics: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Secretaria de Estado da Saúde de Rondônia	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3qyt32y	<NULL>	Patients admitted to the ICU of AMI and CEMETRON hospitals; age above 18 years; presence of forte in the airways; Under the use of controlled mechanical ventilation; no ventilatory drive; No asynchronies; Intubated or tracheostomized Patients admitted to the ICU of AMI and CEMETRON hospitals; age above 18 years; presence of forte in the airways; Under the use of controlled mechanical ventilation; no ventilatory drive; No asynchronies; Intubated or tracheostomized	Hemodynamically unstable; who had a rib fracture; intracranial hypertension; bronchospasm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-3hp5yvh	Effects of aquatic physical exercises in healthy adults and elderly people with Parkinson&apos;s disease	Recruiting	Intervention	2023-06-20	<NULL>	<NULL>	6161	Effects of an Aquatic Physical Exercise Program (APEP) on motor, non-motor and cardiorespiratory aspects in healthy adults and elderly people with Parkinson&apos;s Disease	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	Departamento de Prevenção e Reabilitação em Fisioterapia da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3hp5yvh	<NULL>	Healthy elderly; people with a clinical diagnosis of idiopathic Parkinson&apos;s disease; both sexes; between stages 1 and 4 of the Modified Hoehn and Yahr Scale; continuous use of dopaminergic medication; with a clinical certificate of physical fitness to attend a heated pool	People in wheelchairs; whether or not due to Parkinson&apos;s disease; cognitive changes; visual changes; hearing changes; history of cardiovascular surgeries; absolute contraindications to use a heated pool	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-9tnwp85	Effect of home Eletric Stimulation on pain in Rheumatoid Arthritis patients with low inflammation	Recruiting	Intervention	2023-06-20	<NULL>	<NULL>	6163	Effect of home Direct Current Transcranial Stimulation on pain in Rheumatoid Arthritis patients with low inflammatory activity: a randomized, controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-24	Hospital de Clinicas de Porto Alegre	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9tnwp85	<NULL>	Participants aged 18-70 years from the arthritis clinic will be included rheumatoid disease at the Hospital de Clínica de Porto Alegre (HCPA) who fulfill the following criteria:Participants diagnosed with RA according to the 2010 American criteria College of Rheumatology and the European League Against Rheumatism and determined by the clinical evaluation of a certified rheumatologist; Participants with RA and generalized pain for more than 3 months that is not of character mechanical or inflammatory, evaluated by a certified rheumatologist;Participants with pain assessed by the EVA-D visual analogue scale with a higher value than 40mm (moderate to severe pain) reported by the participant and/or recorded in the last consultations within the 3-month period prior to inclusion; Inflammatory Tests CRP less than 0.5 mg/dl and ESR less than 15 mm/h in the last exams performed in the 3-month period prior to inclusion; Treatment for stable RA, defined as unchanged doses of NSAIDs and/or opioids and/or DMARD in the 6 months prior to the start of the study protocol and doses of prednisone less than or equal to 5mg per day in the 6 months preceding the study; Stable treatment of antidepressants or anticonvulsants if using them for the treatment of pain, defined as no dose changes in the 6 months that precede the study; Possibility of maintaining doses of NSAIDs, DMARDs, corticosteroids, antidepressants and anticonvulsants without changes during the study; Being right-handed; Ability to give informed consent	Having contraindications for the use of Transcranial Direct Current Stimulation (tDCS): history of brain surgery, history of traumatic brain injury, history of stroke, previous implantation intracranial of any type of metal, pregnant or breastfeeding; Have a previous history of an autoimmune disease other than rheumatoid arthritis, fibromyalgia and osteoarthritis; Have a previous history of neurological disease; Have a previous history of neoplasia; Have a previous history of any other uncompensated medical illness (heart disease,kidney disease, liver disease, etc.); Use of illicit drugs in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-3vsv5gs	Muscle Pressure Estimation With Artificial Intelligence During Mechanical Ventilation	Recruiting	Intervention	2023-06-20	<NULL>	<NULL>	6164	Validation of Inspiratory Muscle Pressure Estimation and Automated Detection of Asynchronies in Patients Under Assisted Mechanical Ventilation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-26	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3vsv5gs	<NULL>	Patients under assisted or assist-control mechanical ventilation; Age &gt; 18; both genders.	Contraindication to esophageal catheter insertion (esophageal cancer or bleeding, esophageal fistula, skull base fracture, uncontrolled coagulopathies); Contraindication to transient neuromuscular blockade; Bronchopleural fistula (persistent air leak); Hemodynamic instability (norepinephrine &gt; 1mcg/kg/min); Gestation; Current sinus infection; Refusal from patient&apos;s family of attending physician; Palliative care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-59bh5rc	Effects of online and face-to-face Pilates classes on the quality of life of the elderly	Recruitment completed	Intervention	2023-06-20	<NULL>	<NULL>	6165	Effects of Pilates training performed remotely and in person on the quality of life of the elderly: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-13	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-59bh5rc	<NULL>	Age between 60 and 70 years; not practicing physical exercises regularly and systematically for at least three months; be literate; have access to the internet and a device for video calling (cell phone, notebook/computer or tablet); have the availability to travel to the School of Physical Education, Physiotherapy and Dance (ESEFID) where classes will take place in the face-to-face format and assessments; not having uncontrolled cardiovascular diseases or associated complications; not present musculoskeletal problems that prevent the practice of physical exercise; reside in the city of Porto Alegre and its metropolitan region	Volunteers who do not attend 75% of the classes taught (regular classes or previously established replacements); physical adversity during intervention period and start the practice of another type of exercise physical concomitant with the project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-9w9pw9q	Study of Caffeine in the Attention and Memory of Women with Premenstrual Tension	Recruitment completed	Intervention	2023-06-20	<NULL>	<NULL>	6166	Study of Caffeine Abstinence on Cognitive Parameters in women of childbearing age with Premenstrual Syndrome	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-09	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9w9pw9q	<NULL>	Women aged 19 to 40; have premenstrual syndrome; drink at least two cups of coffee daily	Regular use of medication; smokers; alcohol consumption more than 2 days a week, chronic diseases; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-6b4zwx3	Effectiveness of Exercise on side effects related to Cancer treatment with Chemotherapy: clinical study with economic evaluation	Recruiting	Intervention	2023-06-20	<NULL>	<NULL>	6875	Effectiveness of Aerobic Training in Chemotherapy-related adverse symptoms during treatment: controlled and randomized trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Cidade de Sao Paulo	Instituto de Assistência Médica ao Servidor Público Estadual	https://ensaiosclinicos.gov.br/rg/RBR-6b4zwx3	<NULL>	Patients over 18 years of age; both genders; diagnosed with cancer and hospitalized in the Clinical Oncology ward of the Institute for Medical Assistance to State Public Servants, São Paulo-SP, to undergo at least one cycle of chemotherapy. Patients without musculoskeletal; cognitive or clinical limitations that interfere with the proposed evaluations and interventions, such as: heart diseases (moderate to severe aortic or pulmonary stenosis; decompensated heart failure; advanced cardiac arrhythmias; myocarditis; unstable coronary insufficiency, for example) will be included in the study; pneumopathies (chronic obstructive pulmonary disease and/or decompensated asthma, for example); diabetes mellitus; decompensated systemic arterial hypertension; serum hemoglobin (Hb) &lt; 8g/dL or hematocrit (Ht) &lt; 25% or platelets &lt; 30,000 mm	Patients expected to be hospitalized for less than three days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-9q3d8mq	Evaluation of the PiccPed® mobile application to prevent erros in chidren an babys who have a Peripherally Inserted Central Catheters	Recruitment completed	Intervention	2023-06-19	<NULL>	<NULL>	6157	Validation of the PiccPed® Mobile Application for prevention of adverse events with Peripheral Insertion Central Catheter in Pediatrics and Neonatology	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-10-07	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-9q3d8mq	<NULL>	To be a Nurse; currently working in pediatric and/or neonatal patient care services; have access to a smartphone or tablet; access the PiccPed® app at the time of research intervention.	Being absent from work during the study stages; declining participation in any stage of the research; not responding to the post-test questionnaire; not accessing PiccPed® when requested.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-96n5x69	Analysis of osseointegration of implants with different macrogeometries: a randomized clinical trial	Data analysis completed	Intervention	2023-06-19	<NULL>	<NULL>	6158	Analysis of osseointegration of implants with a new macrogeometry: randomized clinical trial in split mouth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-07	pontifícia universidade católica do paraná	pontifícia universidade católica do paraná	https://ensaiosclinicos.gov.br/rg/RBR-96n5x69	<NULL>	partial edentulous patients in the posterior region of the mandible requiring one implant in each half-arch or two implants in each half-arch;minimum bone height of 11 mm and minimum bone thickness of 5 mm in the posterior region of the bilateral mandible evaluated by means of cone beam computed tomography; sufficient prosthetic space for subsequent prosthetic rehabilitation	the need for some type of bone reconstruction or advanced surgery to allow the installation of the implant; patients who did not accept to be part of the study; patients with uncontrolled diabetes, considering glycated hemoglobin above 7.5%; smokers more than 10 cigarettes a day; use of oral or injectable bisphosphonates; immunodeficient patients; patients who underwent radiotherapy in the head and neck region for a period of less than five years before the beginning of the research; patients with another systemic condition that contraindicated performing oral surgery at the time or who had conditions that could interfere with the osseointegration process	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-8y3qx39	Efficacy of nursing consultation guided by Felix&apos;s Theory in improving risk of impaired cardiovascular function: a randomized clinical trial	Not yet recruiting	Intervention	2023-06-19	<NULL>	<NULL>	6159	Effecacy of the Felix Theory-based nursing consultation in improving risk of impaired cardiovascular function: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-15	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-8y3qx39	<NULL>	Having the nursing diagnosis risk of impaired cardiovascular function; being aged ≥18 years and &lt; 60 years; both genders; being enrolled in Comprehensive Health Care Center	Reporting a diagnosis of cardiovascular disease; presenting impediments to obtaining anthropometric measurements (pregnant women, wheelchair users) or requiring instruments adapted for the execution of interventions (physically, hearing, and visually impaired), not yet developed by other researchers; being in temporary or permanently impaired mental conditions that make it impossible for them to be aware of and cooperate with the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-6dpzvty	Effect of Amitriptyline Cream on Muscle and Joint Pain	Not yet recruiting	Intervention	2023-06-19	<NULL>	<NULL>	6160	Effect of Base Cream with 5% Amitriptyline on Orofacial Pain: Muscle and Joint	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6dpzvty	<NULL>	Age equal to or greater than 18 years; Undergraduate and postgraduate students at the Piracicaba School of Dentistry; Complaint of persistent facial and/or joint pain (TMJ) present for at least 3 months that corresponds to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) (Pereira and Gonçalves, 2020; Schiffman, 2014). The diagnostic nomenclature of Axis I and Axis II of DC/TMD will be used; Having accepted and signed the Informed Consent Form	Under 18 years old; Present other pain syndromes; Refusal to adhere to treatment using topical drugs; Report an allergy to any component of the formula; Make use of antidepressant, anticonvulsant and anti-inflammatory; Be under the direct supervision of the researchers (developing some type of activity in undergraduate and postgraduate courses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-3k9stq8	Effects of a mindfulness program on emotional intelligence and stress in public school teachers	Recruiting	Intervention	2023-06-16	<NULL>	<NULL>	6152	Burnout and emotional intelligence: assessment of the effects of an intervention program based on Mindfulness on public school teachers	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3k9stq8	<NULL>	Be over 18 years of age; to be a teacher in any public school in Brazil; be available to participate in eight sessions of the intervention	Have participated in any Mindfulness-based intervention or have had regular practice in the last 3 months; present a diagnosis of major depressive episode or manic or hypomanic episode or psychotic disorder or substance use disorder in the last 12 months; be at risk of suicide	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-4ywf4tk	Pressure titration offered by electrical impedance tomography-guided ventilation in intubated children with respiratory failure	Recruiting	Intervention	2023-06-16	<NULL>	<NULL>	6154	Positive end-expiratory pressure titration guided by electrical impedance tomography vs. clinical titration in children with Hypoxemic Acute Respiratory Insufficiency : a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-11-12	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4ywf4tk	<NULL>	Patients 1 month to 18 years old; both genders; admitted to the Pediatric Intensive Care Center -CTIP - of the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto, University of São Paulo -HCFMRP USP - with hypoxemic acute respiratory failure (PaO2/FiO2 less than or equal to 300 mmHg) and/or P -ARDS undergoing invasive mechanical ventilation for less than 24 hours	Chest circumference below 38 cm; tracheal tube without cuff; hemodynamic instability; chest imaging showing pneumomediastinal or non-pneumothorax drained; heart disease (congenital or acquired); recent thoracic surgery (&lt; 2 months); skin lesions on the chest wall or drains that prevent the use of the strap to data acquisition; severe brain injury and/or intracranial hypertension; refusal of parents or guardians to consent to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-4tpbssz	Evaluation of blood glucose and cholesterol levels in people who ingested Acai Coffee	Not yet recruiting	Intervention	2023-06-16	<NULL>	<NULL>	6155	Evaluation of glycemic levels, total cholesterol and triglycerides after ingestion of Toasted and Ground Açaí Core Infusion	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-10-01	Universidade Federal do Tocantins	Universidade Federal do Tocantins	https://ensaiosclinicos.gov.br/rg/RBR-4tpbssz	<NULL>	Serving professionals at the Federal University of Tocantins/UFT located on the Palmas/TO campus who wish to take part in the research and comply with the TCLE; of both genders; aged between 30 and 50 years	Pregnant and lactating participants, due to the lack of evidence that the studied herbal medicine, even if natural, may pose a risk; people with diabetes or those who during screening have blood glucose levels higher than 99 mg/dL, as the tests are carried out with glucose administration; participants with a known history of food allergy to açaí or any derivative; any other personal reasons that prevent them from carrying out the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-4ng4kwf	Partnerships and technological innovation: analysis of the partnership model between IBMP (Instituto de Biologia Molecular do Paraná) and ICC/FIOCRUZ (Instituto Carlos Chagas da Fundação Oswaldo Cruz) in the state of Paraná	Recruiting	Observational	2023-06-16	<NULL>	<NULL>	6747	Partnerships and technological innovation: analysis of the partnership model between IBMP and ICC/FIOCRUZ  in the state of Paraná	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-08-28	Universidade Federal do Rio de Janeiro	IBMP – Instituto de Biologia Molecular do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4ng4kwf	<NULL>	Interviews - both genders; minimum age of 18 years; have participated directly or indirectly in the partnership between IBMP and ICC/Fiocruz Paraná; have signed the electronic ICF. Questionnaire 2 Portuguese or English - both sexes; older than 18 years; be a working employee of IBMP or Fiocruz for at least five years; have signed the electronic ICF. Questionnaire 3 Portuguese or English - both sexes; older than 18 years; be active collaborators; act directly or indirectly in research projects in the health area in the last 5 years; be residents of Brazil; have signed the electronic ICF. Questionnaire 4 Portuguese or English - both sexes; older than 18 years; be active collaborators; act directly or indirectly in research projects in the health area in the last 5 years; be residents outside Brazilian territory; have signed the electronic ICF	Group of interviewees - declare unavailability to carry out the interview or to answer questions during the interview. Group invited to answer Questionnaire 2 - being retired; declare unavailability to answer Questionnaire 2 or not answer Questionnaire 2. Group invited to answer Questionnaire 3 - be a retired employee; be a professional linked to IBMP or Fiocruz; have answered Questionnaire 2 or 4; declare unavailability in answering Questionnaire 3 or not answering Questionnaire 3. Group invited to answer Questionnaire 4 - be a retired employee; be a professional linked to IBMP or Fiocruz; have answered Questionnaire 2 or 3; declare unavailability to answer Questionnaire 4 or not answer Questionnaire 4	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-7468j4q	Treatment of Diabetic macular edema with intravitreal injection of antiangiogenic agents with or without Dexamethasone	Not yet recruiting	Intervention	2023-06-15	<NULL>	<NULL>	6150	Treatment of Diabetic Macular Edema with intravitreal injection of anti-VEGF agents with or without Dexamethasone 4 mg/mL solution, randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7468j4q	<NULL>	Age equal to or greater than 18 years; both genders; diagnosis of diabetes; presence of clinically significant diabetic macular edema in at least one eye according to the ETDRS (Early Treatment Diabetic Retinopathy Study) guidelines; Best Corrected Visual Acuity between 20/400 and 20/40; Central Macular Thickness &gt;= 300 µm, measured by Spectral Domain Optical Coherence Tomography	Any diabetic macular edema treatment in the last 4 months; Panretinal photocoagulation in the last 4 months; any eye surgery performed in the last 4 months; history of Pars Plana Vitrectomy; hx of open-angle glaucoma or corticosteroid-induced elevated intraocular pressure requiring ocular antiglaucoma or antihypertensive treatment; intraocular pressure &gt;= 21 mmHg; history of allergy to any product used in the procedure; presence of tractional retinal detachment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-7mhpvxk	Use of photobiomodulation in users of the breastfeeding clinic in the SUS-BH network	Recruiting	Intervention	2023-06-15	<NULL>	<NULL>	6151	Breastfeeding clinic in the SUS-BH network: characterization of users of the service and use of Photobiomodulation in nipple trauma	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2021-08-09	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7mhpvxk	<NULL>	Postpartum women over 18 years old; nursing mothers; with a diagnosis of abrasions, breast fissures or ulcerations in at least one of the breasts; absence of cognitive deficit; absence of malignant alterations for puerperal women; absence of ankyloglossia with indication of frenotomy for babies	Postpartum women who have photosensitivity or any adverse reactions to exposure to sunlight; who is pregnant; who is using other forms of treatment for nipple trauma (ointments, sunbathing, own milk, among others); undiagnosed lesions on the area to be irradiated or close to it; infection at the application site; use of a pacemaker or other electronic implant; who present a diagnosis of mastitis or breast candidiasis, during the development of the study, according to a medical evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-58pm9jh	Empathy project - the use of Cognitive Behavioral Therapy in children and adolescents in the dental office	Not yet recruiting	Intervention	2023-06-14	<NULL>	<NULL>	6149	Empathy project - evaluation of Cognitive Behavioral Therapy resources in the approach to child and adolescent patients in the dental office	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-58pm9jh	<NULL>	Children and teenagers; both genders; Brazilians literate in Portuguese; who did not need emergency dental care; who had dental anxiety; it will also be essential that both children/adolescents and parents/guardians are interested in self-help therapy for inclusion in the study	Individuals who are undergoing psychiatric/psychological treatment or who have some limitation that makes it difficult for them to understand the guides will be excluded from the sample	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-3rx5m6z	Impact of a Global Physical Exercise Program on the Physical Capacity of Elderly After Hospitalization	Recruitment completed	Intervention	2023-06-13	<NULL>	<NULL>	6146	Impact of a Multicomponent Exercise Program on the Functional Capacity of Elderly Post-Hospital Admissions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-20	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUÍ	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUÍ	https://ensaiosclinicos.gov.br/rg/RBR-3rx5m6z	<NULL>	Age equal to or greater than 65 years; Both sexes; Hospital discharge from April to November 2022 at the hospital of a medical cooperative located in the northwest region of the State of Rio Grande do Sul/Brazil; Accept to participate in the study by signing the Free and Informed Consent Term (FICT); Live in the city of Ijuí in the urban area; Ability to walk with or without an aid; Score above 23 points on the Mini Mental State Examination (MMSE); Score less than or equal to 5 points on the 15-item Geriatric Depression Scale (GDS-15);	Practice physical activity or sport after hospital discharge; Acute myocardial infarction or recent unstable angina; Uncontrolled atrial or ventricular arrhythmias; Dissecting aortic aneurysm; severe aortic stenosis; Endocarditis/Acute Pericarditis; Acute Embolic Thrombotic Disease; Severe Acute Heart Failure; Severe Acute Respiratory Failure; Recent fracture (in the last three months), without medical clearance to perform physical activity; Surgery in the last three months and without medical clearance to perform physical activity; Any other circumstance that has a medical contraindication to perform physical activity.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-8nx9n4d	Daily Diabetes program	Recruiting	Intervention	2023-06-13	<NULL>	<NULL>	6147	Educational program for self-management in type 2 diabetes Diabetes em dia (Dia D program): study to assess acceptability and feasibility	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-20	Universidade Paulista - UNIP	Universidade Paulista - UNIP	https://ensaiosclinicos.gov.br/rg/RBR-8nx9n4d	<NULL>	adults over the age of 18 with a medical diagnosis of type 2 diabetes who have not received a structured diabetes education for at least one year; with access to digital communication platforms and digital proficiency	pregnant women; people with cognitive or functional limitations that make difficult to make lifestyle modifications (eg, with severe depression, kidney failure, diabetic retinopathy, and neuropathy)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-6jpgyjr	Efficacy of in-office bleaching using coupled bleaching gel after one week of manipulation	Recruiting	Intervention	2023-06-13	<NULL>	<NULL>	6148	Efficacy of in-office bleaching using coupled bleaching gel after one week of manipulation: a randomized triple-blind and equivalence clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-12	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6jpgyjr	<NULL>	Age between 18 and 60 years; both genders; good general and oral health; healthy vital teeth; minimum color A2; agree and sign the informed consent form (TCLE)	Whitening procedure previously; previous dental sensitivity; dental prosthesis; fixed orthodontic appliance; restorations in the anterior superior teeth; endodontic treatment on anterosuperior teeth; gingival recessions; teeth stained by tetracycline or fluorosis; visible cracks in the teeth; continuous use of medications; pregnant or lactating women; bruxism; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-10ms8yjv	Evaluation of absorbable Dressing containing Red Propolis for use in chronic Wound: clinical study	Recruiting	Intervention	2023-06-13	<NULL>	<NULL>	7886	Evaluation of bioactive Dressing containing Red Propolis Extract or Red Propolis Wax for use in chronic Wounds: clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-15	Universidade Federal de Alagoas	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-10ms8yjv	<NULL>	Minimum age of 18 years. Volunteers with chronic venous injury using unna boot compression or elastic therapy. Surface area up to 150 cm2. Wound covered with &gt; 50% granulation tissue, no black necrotic tissue on the wound surface, and spaced &gt; 3cm from any wound edge to another wound located on the same limb. Both genders. Variable nutritional status and hydration. They may carry the most varied clinical pathologies	Hypersensitivity to one of the dressing components, poor health, body mass index (BMI) in the grade 3 obesity range, erysipelas, cellulitis, lymphangitis, chronic lymphedema. Malignant wound degeneration or neoplastic lesion treated by radiotherapy, chemotherapy and immunosuppressive drugs or corticosteroid dose. Clinically infected lesion requiring a systemic antibiotic. History of deep or superficial venous thrombosis in the previous three months. Have undergone surgery directly related to venous insufficiency within two months prior to inclusion. Wound surgery planned during the trial period. Patients who are in the terminal phase will not be included in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-6hxffx4	Use of laser Auriculotherapy in Cancer patients in palliative Chemotherapy	Recruitment completed	Intervention	2023-06-11	<NULL>	<NULL>	6145	Auriculotherapy and Relaxation with Guided Image in Cancer patients in palliative Chemotherapy: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Programa de Pós Graduação em Enfermagem da Universidade Federal do Paraná	Programa de Pós Graduação em Enfermagem da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6hxffx4	<NULL>	Age 18 years or over, of both sexes; having been diagnosed with advanced breast cancer and starting palliative chemotherapy treatment at the SUS clinical oncology clinic at the Erasto Gaertner Hospital; patients diagnosed with stage III or IV advanced breast cancer, regardless of the chemotherapy plan (number of sessions, adverse effects, duration of treatment)	Patients with tumor located in the pinna	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-10brpqhz	Evaluation of an Investigational Product in the Restructuring of the skin protection barrier	Not yet recruiting	Intervention	2023-06-09	<NULL>	<NULL>	6142	EN22-0674-05_ Evaluation of the efficacy of the Investigational Product in the Restructuring of the Cutaneous Barrier through the kinetic phase, after the Tape Stripping procedure	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Medcin Instituto da Pele Ltda	Megalabs Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-10brpqhz	<NULL>	Participants of both sexes; aged between 18 and 60 years; intact skin in the region of the forearms; agreement to follow the trial procedures and to attend the clinic on the day and times determined for applications and/or evaluations; understand, consent and sign the informed consent form	Participants diagnosed with COVID-19 in the last 4 weeks or showing symptoms such as fever, dry cough, tiredness, body aches or other discomfort; pregnancy/lactation or intention to become pregnant during the study period; use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to 30 days before selection or considering immunosuppressants, the interval should be 3 months before selection; history of atopy and history of allergies to cosmetic products; pathologies and/or active skin lesions (local and/or disseminated) in the evaluation area; skin marks in the experimental area that interfere with the evaluation of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevus, sunburn); pathologies that cause suppression of immunity, such as diabetes, HIV, etc.; decompensated endocrinopathies; participants with known congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known history of or suspected intolerance to products in the same category; intense sun exposure up to 15 days before the evaluation; aesthetic or dermatological treatment in the evaluation area up to 04 weeks before selection; professionals directly involved in performing this study; other conditions considered by the evaluating physician as reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-88kny27	Evaluation of the effect of Desensitizers on Tooth Whitening	Terminated	Intervention	2023-06-09	<NULL>	<NULL>	6143	Influence of different Desensitizers protocols in the control of Sensitivity after Tooth Whitening: a blinded and randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-88kny27	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 to 35 years; not having performed teeth whitening before; have all vital anterior teeth; no restorations on anterior teeth; incisor color A2 or darker by evaluation with Vita scale (Vita, Bad Säckingen, Germany)	Patients with severe systemic conditions; with missing front teeth; with teeth infected by caries lesions; anterior teeth with presence of recession; upper teeth with some kind of restorative or prosthetic treatment; patients who have a history of dental hypersensitivity; patients who had tooth discoloration by tetracycline or fluorosis; who uses many medications; fall under the condition of pregnant or lactating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-2dd6x6r	Control of fluid volume in people on hemodialytic regime	Recruitment completed	Intervention	2023-06-09	<NULL>	<NULL>	6144	Effectiveness of the nursing intervention control of fluid volume in people on hemodialytic regime: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-2dd6x6r	<NULL>	Having a medical diagnosis of Chronic Kidney Disease. Be on hemodialysis treatment for at least 8 months. Be registered and monitored at the Baturité dialysis clinic. Be over 18 years old. Both genders. Having the nursing diagnosis excessive fluid volume. Having scored less than 4 points on the expected fluid balance nursing outcome scale	Be in temporarily or permanently impaired mental conditions that make it impossible for you to be aware of and cooperate with research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-973pt5n	Study of the treatment of Chronic Chagas disease and with cardiac involvement in adults based on the regions of Brazil	Not yet recruiting	Intervention	2023-06-07	<NULL>	<NULL>	6140	BENBRASIL Trial - prospective study of efficacy and safety of Benznidazole, with randomized, double-blind phase II study of Benznidazole compared to Nifurtimox in adults with Chagas Disease in chronic indeterminate or mild cardiac forms, in Brazil	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-08-01	Instituto Nacional de Infectologia Evandro Chagas	Ministerio da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-973pt5n	<NULL>	Both sexes; older than 18 years; having two positive serological tests for Chagas disease; weight between 50 kg and 95 kg	Previous treatment with Benznidazole or Nifurtimox, pregnant women, breastfeeding or expressing gestational desire for the next 2 months; Any concomitant use or documented history of use of allopurinol or antifungals ketoconazole, itraconazole and posaconazole; History of hypersensitivity, allergic or severe adverse reactions to any nitroimidazole compound and/or its components; liver disease with liver failure and kidney disease requiring supportive treatment; Sinais and/or symptoms of the severe cardiac form of Doença de Chagas; History of cardiomyopathy, heart failure, or severe ventricular arrhythmia of any etiology; Participation in another clinical trial in the last 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-3sdgfyy	Dipyrone for the acute treatment of Dialysis Headache	Not yet recruiting	Intervention	2023-06-07	<NULL>	<NULL>	6141	Evaluation of Dipyrone in the acute treatment of Dialysis Headache: a randomized, double-blind, placebo-controlled study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2023-06-30	Pós Graduação em Neuropsiquiatria e Ciências do Comportamento - Universidade Federal de Pernambuco	Hospital das Clínicas da Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3sdgfyy	<NULL>	Patients of both genders; aged 18 years or over; on hemodialysis treatment for chronic renal failure; diagnosed with dialysis headache according to the criteria of the International Classification of Headache Disorders (ICHD-3); who experience this headache during dialysis	Patients who have a known diagnosis of Acute Chronic Renal Failure; patients who are allergic to dipyrone	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-5tkh5hv	Effects of Photobiomodulation on heart rate variability responses in bodybuilders	Recruitment completed	Intervention	2023-06-06	<NULL>	<NULL>	6137	Assessment of heart rate variability in bodybuilders	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-14	Universidade Brasil	Universidade Brasil	https://ensaiosclinicos.gov.br/rg/RBR-5tkh5hv	<NULL>	Non-athletes, who practice light physical activities (according to the perceived effort scale proposed by Borg (2000). Both sexes and who do not have a history of musculoskeletal injury in the regions of the arms, hips and knees; Age between 18 and 50 years and who can give informed consent; Physical exercise training for at least 03 months; Healthy individuals who do not have contraindications to Photobiomodulation Therapy (FBM)	Chronic alcoholic or who frequently ingest caffeine products; vasodilators, psychotropics and anti-inflammatory drugs; Individuals with neurological and muscular diseases; Pain or limitation in movements of the upper or lower limbs and suffered some type of serious injury in the last six months; Having chronic systemic diseases, for example, diabetes mellitus, systemic hypertension, cardiovascular, renal, brain diseases, neoplasms or HIV-AIDS; Cognitive inability to understand or communicate important	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-29fy354	Non-invasive treatment of urinary symptoms and quality of life in women with Multiple Sclerosis	Recruiting	Intervention	2023-06-06	<NULL>	<NULL>	6138	Effect of Electrical Stimulation of the posterior tibial nerve on urinary symptoms and quality of life in women with Multiple Sclerosis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-30	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-29fy354	<NULL>	Women; aged 18 to 59 years; with a clinical diagnosis of multiple sclerosis according to the Macnonald classification, of the relapsing type; who have symptoms of urinary disorders for at least six months; diagnosed with detrusor overactivity in the urodynamic test; if you cannot get a urodynamic test, the criterion will be at least three of the following symptoms: urgency, urge urinary incontinence, increased urinary frequency, nocturia and nocturnal enuresis	Skin lesions in the area to be treated; cervical, rectal, or genitourinary cancer; if they are pregnant; cardiac pacemaker carriers; presence of urinary tract infection; cognitive decline or illiteracy; presence of genital prolapses; performing abdominal surgeries less than 6 months ago; who already has some history of previous treatment with pelvic floor exercises; who makes previous use of antimuscarinics or other specific medication to control overactive bladder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-94bszgk	Effects of association of an intensive motor training and brain stimulation on gait, balance and legs movement of people who suffered a stroke	Not yet recruiting	Intervention	2023-06-06	<NULL>	<NULL>	6139	Association of Lower Extremities - Constraint Induced Movement Therapy (LE-CIMT) and Transcranial Direct Current Stimulation (tDCS) on functionality and performance of lower limbs, gait and balance of post-stroke patients ¿ Triple-blinded, controled, randomized Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-03	Associação de Assistência a Criança com Deficiência	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-94bszgk	<NULL>	Medical diagnosis of a single Stroke with more than six months of injury; both genders; minimum age of 18 years old and maximum age of 79; clinically stable; presenting hemiparesis as a sequel to the stroke; present a gait deficit caused by the sequelae of the stroke, classified at Level 3 to 5 of the Functional Ambulation Classification; go from sitting to standing independently even with the help of upper limbs; not having undergone orthopedic surgery in the last 6 months or chemical blockade in the last 3 months prior to the beginning of the study; no history of seizures; without anticonvulsant medication	Not tolerate the electrical stimulation; lesions in the scalp region where there will be electrode contact; to present convulsive episode during the protocol; epileptic Focus on Electroencephalogram exam even with no clinical manifestation; to have brain implant; to have cardiac markpacer; diagnosed or investigating bipolarity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-6gv37z8	Evaluation of skin and child Acceptability for Cosmetic Product	Not yet recruiting	Intervention	2023-06-05	<NULL>	<NULL>	6133	EN22-0674-03_Evaluation of dermal and pediatric Acceptability for Cosmetic Product	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-20	Medcin Instituto da Pele Ltda	Megalabs Farmacêutica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-6gv37z8	<NULL>	Participants of both sexes aged between 0 and 3 months; intact skin in the product analysis region; up-to-date vaccination card; be a user of cosmetic products of the same category; parents or legal representative willing to obey the trial procedures and be available for telephone contacts and/or via WhatsApp and telemarketing, with internet access on the days and times determined for the assessments; parents or legal representative who have a mobile device suitable for use and with access to the internet network for telephone contacts and/or via WhatsApp and call center, with internet access; parents or legal representative willing to attend the Clinical Research Center if necessary for evaluations; parents or legal representative of the participants must understand and agree with the Free and Informed Consent Term (TCLE) and consent to the participation of their child	Participants and parents or legal representative who have been diagnosed with COVID-19 in the last 4 weeks or who are experiencing symptoms such as fever, dry cough, tiredness, body aches or other discomforts; use of anti-inflammatory/ immunosuppressive/ antihistamine drugs up to 3 weeks before selection; skin marks in the experimental area that interfere with the evaluation of possible skin reactions (vascular malformations, scars, increased hairiness, large amounts of nevus, sunburn); atopic or allergic history to cosmetic products; pathologies and/or active skin lesions (local and/or disseminated) in the assessment area; immunosuppression by drugs or active diseases; decompensated endocrinopathies; known history of or suspected intolerance to products in the same category; intense sun exposure up to 15 days before the evaluation; aesthetic or dermatological treatment in the evaluation area up to 04 weeks before selection; children of employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; other conditions considered by the researcher as reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-5xcqs47	Effects of using an Ankle Binding Technique to gain flexion of the dorsum of the foot range of motion and dynamic ankle balance: a randomized controlled trial	Recruiting	Intervention	2023-06-05	<NULL>	<NULL>	6134	Effectiveness of self-application of a Talar Stabilizing Taping on dorsifflexion range of motion and dynamic stability of the ankle in crossfit practitioners: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-06	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Maynart Sports Center	https://ensaiosclinicos.gov.br/rg/RBR-5xcqs47	<NULL>	The sample will be composed of individuals who practice CrossFit; of both sexes; who report being practitioners of the sport for a minimum of 3 months with a weekly frequency of more than 2 days.	Individuals who report a history of ankle sprain in the last 6 weeks will be excluded; individuals with limited range of motion due to edema identified through the cacifo&apos;s test and measurement of ankle circumference compared to the contralateral ankle; individuals with range of motion limitation due to reported pain; individuals reporting vestibular dysfunction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-5fzq2w7	Evaluation of the Types of Hydration Solutions Used in Renal Transplantation	Recruitment completed	Intervention	2023-06-05	<NULL>	<NULL>	6135	Impact of the Crystalloid Solutions on the occurrence of Acidosis and Hyperkalaemia in Renal Transplantation: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Hospital Universitário Onofre Lopes	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-5fzq2w7	<NULL>	Patients  submitted to renal transplantation in Hospital Universitário Onofre Lopes	Patient refusal;Patients younger than 18 years; patients with preoperative serum potassium greater than 5.5 mEq / L; additional surgery to the renal transplant in the same surgical time; intraoperative complications requiring additional volume expansion  (eg bleeding)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-7jt6zny	Impact of Music in childhood	Not yet recruiting	Intervention	2023-06-05	<NULL>	<NULL>	6136	Effects of Music Training in childhood: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Bravo Academia de Música	https://ensaiosclinicos.gov.br/rg/RBR-7jt6zny	<NULL>	Children with a minimum age of 180 days and maximum age of 209 days of life at the pre-intervention time; of both genders; Term born with no history of risk factor for developmental delays; parents and first-degree relatives who are not music professionals; result passes neonatal hearing screening; brainstem auditory evoked potential with presence of wave V at 30 dBnHL at the pre-intervention moment; parents or guardians have not been exposed to the formal musical approach during the gestation period	Children who present failure in neonatal hearing screening; history of disease in the first six months of life; neurological alterations; motor impairment and syndromes; external, middle and/or inner ear malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-7zq9d89	Acute effect of the Sit-Stand Table on Nervous System Control of Heart and Arteries of healthy people: crossover, randomized and controlled clinical trial	Recruiting	Intervention	2023-06-04	<NULL>	<NULL>	6132	Acute effect of the Sit-Stand Table on Cardiovascular Autonomic Control in normal-weight individuals: crossover, randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-7zq9d89	<NULL>	Be between 23 and 45 years of age; work for a period equal to or greater than 4 hours in a seated position and use the computer as their main work tool; not report suffering of chronic health problems; being a non-smoker for more than 1 year; for women, being in the follicular phase, in the period between the seventh and tenth day of the menstrual cycle, i.e., between the end of menstruation and mid-cycle; agreeing to participate in the study; and, not having symptoms of coronavirus disease 2019 (COVID-19).	Having a physical condition that prevents them from performing postural changes from sitting to standing or standing for more than 20 minutes; having signs and symptoms of pregnancy or being in gestational period; report having cardiovascular diseases [heart failure, coronary artery disease, arterial hypertension, changes in heart rhythm (atrial fibrillation, ventricular arrhythmia, ventricular tachycardia), valvular heart disease, acute myocardial infarction]; having the following conditions: type 1 and 2 diabetes, cardiac pacemaker, personal or family history of venous thrombosis or pulmonary embolism, presence of stroke sequelae; being an alcoholic, user of tobacco, nicotine products and illicit drugs; regularly use immunosuppressive drugs, corticosteroids, vasodilators, anxiolytics, beta-blockers and insulin; women with regular use of contraceptives or hormone replacement; and, menopausal women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-2d3jj9t	Effects of Brain Stimulation combined with Neural Mobilization in people with sciatica	Recruitment completed	Intervention	2023-06-04	<NULL>	<NULL>	8106	Effects of Transcranial Direct Current Stimulation on pain, disability and quality of life in individuals with chronic sciatica: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-28	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2d3jj9t	<NULL>	"Men and women between 18 and 64 years. Clinical diagnosis of low back-related leg pain for at least three months. Radiating pain to at least one lower limb in the last two weeks. Presence of two or more of the following clinical criteria; positive neural tension test (SLRT); neurological deficit; pain below the knee; pain more present in the leg than in the lumbar; and subjective sensory symptoms. 
Not being under physiotherapeutic treatment for low back-related leg pain for at least 60 days"	To present any contraindication for tDCS brain stimulation; Douleur Neuropathique Questionnaire score under 4 points; Pain Numeric Rating Scale score under 3 points; Presence of Red Flags for critical spinal pathology; Have been submitted to some type of infiltration in the spine in the last six months; History of abdominal, lumbar or lower limb surgery in the last year; Inability to respond to the study&apos;s assessment instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:44
RBR-34yvspy	Exercise effect using Passive Cycle Ergometry and Electrostimulation Neuromuscular in lower limbs on variables metabolic, respiratory and hemodynamic parameters in neurological patients admitted to an intensive care unit	Recruiting	Intervention	2023-06-03	<NULL>	<NULL>	6131	Effect of an Early Mobilization Program in different protocols on metabolic, hemodynamic, functional and psychological variables in patients hospitalized in an intensive care unit: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-14	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-34yvspy	<NULL>	patients of both sexes; age greater than or equal to 18 years; use of invasive mechanical ventilation for a period of more than 24 hours; which is have functional level I for the mobilization of critically ill patients, as Morris et al. (2008); without use of sedoanalgesia for a period great or equal to  24 hours; variability of less than 20 per cento of the frequency heart rate; systolic blood pressure less than 200 mmHg or greater than 90 mmHg; normal electrocardiogram (no evidence of myocardial infarction) myocardial infarction or arrhythmia); peripheral oxygen saturation greater than 90 per cento; fraction of inspired  oxygen less than 60 per cento; without signs of respiratory distress; respiratory rate  less than 25ipm; stable hemoglobin more than 7 g/dL; stable platelet count more than 20,000 cells/mm3; leukocyte count of 4,300 - 10,800 cells/mm3; body temperature greater or equal to 38°C; blood glucose levels of 3.5 - 20 mmol/L; clinically stable without the use of vasoactive drugs and/or minimal doses; absence of pain, fatigue and dyspnea; creatine phosphokinase less yhan 400U/L; lactate less than 3mmol/L	suspected and/or confirmation of brain death; in palliative care; patients who present fracture or amputation of lower limbs; pregnant women; presence of cardiac pacemaker or implantable cardioverter-defibrillator; neuromuscular disorders; deep vein thrombosis or pulmonary embolism treated for less than 48 hours; patients who are unable to perform the cycle ergometer or electrical muscle electrostimulation due to the osteomioarticular, dermatological or surgical dysfunctions; Body mass index greater or equal to 35Kg/m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-104h4s4y	Motor and psychological effects of intervention with Transcranial Direct Current Stimulation (tDCS) for Physiotherapeutic treatment in children with Cerebral Palsy	Recruiting	Intervention	2023-06-02	<NULL>	<NULL>	6130	Motor and psychic effects of intervention with Transcranial Direct Current Stimulation (tDCS) for treatment with and without Physical Therapy in children with Cerebral Palsy	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-17	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-104h4s4y	<NULL>	Children of both sexes with cerebral palsy diagnosed by a neurologist; who were between 8 and 12 years old; with Gross Motor Function Classification levels I or II; independent gait for at least 1 year and a degree of understanding with the execution of the procedures to be performed.	Children without cerebral palsy; or who have other neurological comorbidities; or who are outside the age group of 8 to 12 years; Volunteers who do not understand simple commands or who remain seated; or who have a history of surgery or neurolytic block in the last year; metal implants in the skull or use of hearing aids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-987njz9	Incidence of pain after single session root Canal Treatments of Necrotic Teeth using a Reciprocating technique for Instrumentation - A clinical study	Recruitment completed	Intervention	2023-06-01	<NULL>	<NULL>	6128	Incidence of pain after Endodontic treatments of Necrotic Teeth in a single session using a Reciprocating technique for Instrumentation - a prospective randomized clinical trial	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Associação Paranaense de Ensino e Cultura	Associação Paranaense de Ensino e Cultura	https://ensaiosclinicos.gov.br/rg/RBR-987njz9	<NULL>	Asymptomatic necrotic teeth with or without periradicular lesions; female and male gender; minimum age 18 years; patients referred for endodontic treatment at the specialization clinic in endodontics at Universidade Paranaense	Patients who use or have recently used analgesics and antibiotics, or continuous use medications; teeth with extensive resorptive processes, coronal and/or root perforations; periodontal compromises; spontaneous and/or acute or moderate painful symptoms on percussion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-102yzxnt	Success of  Restorations of Milk Teeth with Glass Ionomer without using Polyacrylic Acid and with the use of Acid - Study with 2 Years Follow-up	Recruiting	Intervention	2023-06-01	<NULL>	<NULL>	7118	Clinical performance of Class I restorations on primary teeth with glass ionomer without preconditioning with 25% polyacrylic acid - Randomized clinical trial with 2 years of follow-up	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-29	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	Hospital Universitário Pedro Ernesto da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-102yzxnt	<NULL>	Healthy children; age between 3 and 9 years; feminine and masculine gender, co-workers in relation to the examination; possibility of follow-up for a few years; with at least one occlusal or occlusal-proximal lesion in a deciduous molar with dentininvolvement	Teeth with restorations; Sealants; forming defects; advanced rhizolize process; deep caries injury that may lead to pulp involvement; teeth with fistula and/or abscess; dental mobility; presence of spontaneous pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-73vcyff	Triathlon performance	Not yet recruiting	Observational	2023-05-31	<NULL>	<NULL>	6123	Performance characteristics in Olympic Distance Triathlon	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de São Paulo	Centro Olímpico de Treinamento e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-73vcyff	<NULL>	triathlete; more than a year of triathlon practice; medical clearance to perform maximum physical exercise	pain and/or any injuries in the lower limbs; medical restriction for maximum effort	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-9pm4r64	Clinical and population characteristics of patients with primary Antiphospholipid syndrome (APS)	Recruiting	Observational	2023-05-31	<NULL>	<NULL>	6124	Clinical and epidemiologic aspects of thrombotic primary Antiphospholipid syndrome (APS)	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-10	Faculdade de Medicina da Universidade de São Paulo	University of Turin	https://ensaiosclinicos.gov.br/rg/RBR-9pm4r64	<NULL>	Patients who meet the Sydney classification criteria for primary Antiphospholipid syndrome; age greater than 18 years old	Patients who do not have primary Antiphospholipid syndrome; patients who do not want to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-337hq7s	Effect of Specific and Non-Specific Exercises on pain in patients with Chronic Neck Pain	Not yet recruiting	Intervention	2023-05-31	<NULL>	<NULL>	6125	Effect of Specific and Non-Specific Exercises on pain processing in individuals with Chronic Neck Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-10	Universidade Federal de São Carlos - UFSCar	Universidade Federal de São Carlos - UFSCar	https://ensaiosclinicos.gov.br/rg/RBR-337hq7s	<NULL>	Age between eighteen and sixty-five years; both sexes; neck pain lasting three months or longer, non-specific (no known causes), with or without irradiation; presence of pain at rest and/or during active cervical movements with a score greater than or equal to three on the Numerical Pain Scale; and score greater than or equal to ten on the Neck Disability Index	Signs of radiculopathy in the upper limbs (loss of muscle strength in the myotome, sensory loss in the dermatomes and/or changes in reflexes); whiplash-associated disorder; cervicogenic headache; fibromyalgia; pregnancy; history of trauma; cervical fractures or surgeries; cervical-related rheumatic inflammatory diseases; neurological; tumors and/or medical contraindication to practice physical exercise; physiotherapy or cervical infiltration in the last three months; starting some physical activity in the last two weeks; use of analgesics, use of anti-inflammatories or muscle relaxants in the twenty-four hours prior to the evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-696xwzw	Surgical versus conservative treatment for acute grade III acromioclavicular dislocation	Not yet recruiting	Intervention	2023-05-31	<NULL>	<NULL>	6126	Surgical versus conservative treatment for acute grade III acromioclavicular dislocation. Randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Fundação Faculdade de Medicina de São José do Rio Preto	Fundação Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-696xwzw	<NULL>	Volunteers of both genders with grade III acromioclavicular dislocation; acute acromioclavicular dislocations; adults between 18 and 65 years old; no medical contraindications for the proposed treatments; acceptance and understanding of the informed consent form	Acromioclavicular dislocations grades I, II, IV, V and VI; dislocation with more than 14 days of evolution; associated neurovascular injury diagnosed on physical examination; head trauma; fracture in the ipsilateral upper limb; previous diseases in the affected limb that may influence the results; medical contraindication for surgery and/or anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:32
RBR-10h8j7q7	Ayla App: Socio-environmental Models that lead to Maternal, Fetal, Neonatal and Infant Consequences	Recruiting	Intervention	2023-05-30	<NULL>	<NULL>	6120	Ayla App: Social and Environmental Models influencing Maternal, Fetal, Neonatal and Children´s Outcomes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-26	Universidade da Região de Joinville	Secretaria Estadual de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-10h8j7q7	<NULL>	"Primiparous pregnant women without previous comorbidities defined at the time of randomization; Literate in the language Portuguese; Aged 18 to 34 years old or older; With gestational age up to 13 weeks considering the date of the last menstruation; Which have the date of the last menstruation defined; Who have planned the birth at Maternidade Darcy Vargas (MDV); Who have a mobile device compatible with the Ayla app and who voluntarily accept to participate in the research by reading and assent of the TCLE being informed the free will to stop participating in the research at any time
time"	Definition of gestational age outside the 1st trimester after performing obstetric ultrasonography (USG); Multiple pregnancy identified later; Abortion during the research; Delivery in a different place other than the Maternity Darcy Vargas; Withdrawal after signing the consent form; Loss of segment of the pregnant woman due to abandonment of follow-up and inability to contact by telephone (including loss or change of telephone number or cell phone)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-10g2hcrj	Topical application of sodium ascorbate after in-office tooth whitening	Recruitment completed	Intervention	2023-05-30	<NULL>	<NULL>	6121	Topical application of Sodium Ascorbate after in-office Tooth Whitening: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-04	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-10g2hcrj	<NULL>	Volunteers must be between 18 and 49 years old; both genders; in good general and oral health; healthy and vital upper anterior teeth (no dentin exposure, no visible cracks in the teeth, restorations, prostheses and endodontics); having the upper right canine (element 13) in A2 color or darker according to the Vita Classical color scale (Vita Zahnfabrik, BadSäckingen, Germany); and who agree with the Informed Consent Form	Who had previously performed tooth whitening; pregnant or lactating women; previous Dental Sensitivity; patients with tetracycline stains (grade I, II, III or IV); or severe discoloration; patients undergoing orthodontic treatment or bruxism; fixed orthodontic; and who are making continuous use of some medication with anti-inflammatory or antioxidant action	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-6hn82h4	Study of Pessary Washing frequencies in the treatment of Genital Prolapse	Recruiting	Intervention	2023-05-30	<NULL>	<NULL>	6122	Periodicity assessment for Cleaning the Vaginal Pessary in the treatment of the Pelvic Organ Prolapse: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Suelene Costa de Albuquerque Coelho	Uiversidade Estadual de Campinas (Unicamp)	https://ensaiosclinicos.gov.br/rg/RBR-6hn82h4	<NULL>	Stage 3 or 4 genital prolapse by POP-Q; Option for vaginal pessary treatment	Women with prolapse not assessed by POP-Q; Women with non-ring model pessaries; Women with cognitive impairment to answer forms and questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-2hsd46j	Effects of Medical painting therapy in patients with Essential tremor	Terminated	Intervention	2023-05-29	<NULL>	<NULL>	6112	Evaluation of the effects of Medical painting therapy Liane Collot d&apos;Herbois in patients with Essential tremor	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-04-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2hsd46j	<NULL>	Min age 18 years; both genders; diagnosed with Essential Tremor; without cognitive impairment; authorized signature of the free and consent form	Schizophrenia; other psychotic disorders; using antipsychotic medications; ex-patient from Medical Painting Therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-10zzpsbx	How Physical Exercise can help children with math Anxiety	Terminated	Intervention	2023-05-29	<NULL>	<NULL>	6113	Implications of Physical Activity in children with math Anxiety	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-13	Instituto de educação Matemática e Cientifica da Universidade Federal do Pará	Instituto de educação Matemática e Cientifica da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-10zzpsbx	<NULL>	Age 9 - 12; enrolled in school	Mathematical learning disorders; blindness; deafness; chronic heart disease; chronic neurological disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-5yr2xjb	Effectiveness of an intervention based on Mindfulness on Stress, Burnout and quality of life of nurses: a randomized clinical trial	Not yet recruiting	Intervention	2023-05-29	<NULL>	<NULL>	6114	Mindfulness, quality of life, perception of Stress and Burnout in nursing professionals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Escola Paulista de Enfermagem	Escola Paulista de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-5yr2xjb	<NULL>	Workers of both genders; of any age; working in a health institution for at least 1 year; exercise the role of nurse; be available to participate in all stages of the randomized clinical trial	Being unemployed, on vacation or on sick leave during the survey period; have a medical diagnosis of psychiatric or neurological disease; use some psychotropic medication and perform some meditative practice regularly in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-109xh8d6	Neuromodulation therapy for Tinnitus and Dizziness	Recruiting	Intervention	2023-05-29	<NULL>	<NULL>	6115	Rehabilitation of the symptoms Tinnitus and Dizziness through Transcranial Direct Current Stimulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-13	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-109xh8d6	<NULL>	Tinnitus group: participants of both genders; aged over 18 years; with current complaint of tinnitus; with or without hearing loss; under follow-up at the Tinnitus outpatient clinic of the University Hospital Onofre Lopes - HUOL/UFRN. Dizziness/vertigo group: participants of both genders; aged over 18 years; with a history of dizziness, vertigo, instability or body imbalance; with an otorhinolaryngological diagnosis of peripheral and/or central vestibular dysfunction; under follow-up at the Otoneurology outpatient clinic of HUOL/UFRN	Patients with severe visual disorders; musculoskeletal, cognitive and psycho-emotional alterations that prevent or hinder the proper performance of assessments and interventions and that interfere with the ability to answer the applied questionnaires. With exclusion criteria for cortical stimulation: use of a pacemaker or other electronic implants, including cochlear implants, metal plates in the skull or body; neurological comorbidities; severe heart disease; history of epilepsy and/or seizures; pregnant/lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-4mtq8d9	Conservative steel crowns for the management of dental enamel defects in permanent molars: a randomized controlled trial	Recruiting	Intervention	2023-05-29	<NULL>	<NULL>	6116	Hall Technique for the management of Hypomineralized first permanent molars: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Programa de Pós-graduação Stricto sensu em Odontologia - Faculdade de Odontologia - Universidade do Estado do Rio de Janeiro	Programa de Pós-graduação Stricto sensu em Odontologia - Faculdade de Odontologia - Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4mtq8d9	<NULL>	Children with at least one first permanent molar affected by molar incisor hypomineralization (MIH) with post-eruptive breakdown; atypical carious lesions; or atypical restoration affecting at least two tooth-surfaces and involving at least one cusp will be eligible for the study	Children presenting other developmental enamel defect than molar incisor hypomineralization (e.g., amelogenesis imperfecta, severe fluorosis); chronic health conditions; symptoms of temporomandibular joint (TMJ) dysfunction, children unable to cooperate with treatment and first permanent molar with signs and/or symptoms of pulp involvement or with orthodontic appliances will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-7rk26hj	Discussion of the evaluation of the treatment of Partial Rupture of the Supraspinatus Tendon with the Needling technique associated with Platelet Rich Plasma	Data analysis completed	Intervention	2023-05-29	<NULL>	<NULL>	6117	Evaluation of the treatment of Partial Rupture of the Supraspinatus Tendon with the Dry Needling technique associated with Platelet Rich Plasma	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-11-30	Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP	Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-7rk26hj	<NULL>	Patients of both sexes, aged over 25 years, with partial rupture of the supraspinatus less than or equal to 1 cm in the longitudinal axis evaluated by ultrasound.	Patients who underwent any ultrasound-guided needling procedure in the affected tendon, use of infiltration with corticosteroids in the affected shoulder in the last 6 months, presence of another pathology of the shoulder to be treated (fracture or arthritis of rheumatic origin), cervical spine radiculopathy, pregnancy, neoplasm, severe liver disease or nephropathy, autoimmune, inflammatory or infectious diseases, acute or chronic, hypersensitivity to lidocaine, use of anti-inflammatory drugs or corticosteroids in any form before 6 weeks of application of platelet-rich plasma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-10chb63w	Use of in-office bleaching agents with different pH in combined bleaching, a randomized clinical trial	Not yet recruiting	Intervention	2023-05-29	<NULL>	<NULL>	6118	Combined bleaching using in-office bleaching agents with pHs different: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-10	Universidade Ceuma	Universidade Ceuma	https://ensaiosclinicos.gov.br/rg/RBR-10chb63w	<NULL>	Healthy volunteers; both genders; minimum age of 18 years and maximum without limit; non smokers; have vital teeth free of carious lesions; non-carious in the anterior region; free from periodontal disease; and the upper right canine should be A2 or darker in color compared to the Vita Classical scale; patients must sign the Informed Consent Form after explaining the details of the research	Volunteers with previous tooth sensitivity; who never performed any type of dental bleaching; smokers, pregnant or breastfeeding women; in continuous use of medications such as analgesics or anti-inflammatories; who do not use prostheses; no restorations on the upper anterior teeth; are not using fixed orthodontic appliance; without any parafunction; no gingival recession; no endodontic treatment of anterior teeth, no severe dental discoloration (tetracycline staining or fluorosis) and visible cracks in teeth	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-6vk277q	Resistance exercise and laser in the prevention of lymphedema in breast cancer	Recruiting	Intervention	2023-05-29	<NULL>	<NULL>	6119	Effects of progressive resistance exercise and photobiomodulation treatment in the prevention of lymphedema secondary to breast cancer	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-6vk277q	<NULL>	Women over 18 years of age who underwent surgery to treat breast cancer with axillary dissection, who have preserved motricity (nerve and muscle functions) in the lower and upper limbs.	Women with metastatic diseases; breast reconstruction; previously diagnosed lymphedema; long thoracic nerve injury; contraindication to physical exercise; previous motor deficiency; arrhythmias and decompensated heart disease; allergy to lymphoscintigraphy contrast.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-4z9h7nk	Surgical treatment of acute acromioclavicular Dislocations	Not yet recruiting	Intervention	2023-05-26	<NULL>	<NULL>	6110	Surgical treatment of acute acromioclavicular Dislocations with or without ligament transfer. Randomized clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Fundação Faculdade de Medicina de São José do Rio Preto	Fundação Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-4z9h7nk	<NULL>	Volunteers of both genders with grade IV and V acute traumatic acromioclavicular dislocation; between 18 and 65 years old; no medical contraindications to general anesthesia; who accept informed consent	Individuals under 18 or over 65 years of age; dislocation with more than 21 days of evolution; presenting associated neurovascular lesion diagnosed in the physical exam and complementary exams; head trauma (Glasgow &lt;12); with associated fracture in the ipsilateral upper limb; inability to maintain outpatient clinical follow-up, that is, patients who will not be able to make the necessary returns for the correct follow-up, or because they are institutionalized, or for being followed up in other services, or other reasons that prevent them from performing the returns in consultations scheduled; with medical contraindication for surgery and/or anesthesia; patients who are unable or unwilling to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-92kyfck	Comparative study of Anterior Cruciate Ligament Reconstruction with Peroneus Longus tendon x Hamstring tendon grafts	Not yet recruiting	Intervention	2023-05-26	<NULL>	<NULL>	6111	Randomized clinical trial comparing the functional outcome of patients undergoing Primary Reconstruction of the Anterior Cruciate Ligament with ipsilateral Peroneus Longus tendon x Hamstring tendon grafts after a 2-year follow-up	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-92kyfck	<NULL>	Patients with anterior cruciate ligament injury with surgical indication, with or without menisci injuries; Both genders	Presence of associated ligament injuries needing reconstruction; Patients with indication of associated procedures, such as osteotomies around the knee; Presence of associated fractures or other pathological conditions of the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-8xzpdbc	Evaluation of the Mat Pilates Method on mental health and on the quality of life of university students: a Randomized Clinical Trial	Recruiting	Intervention	2023-05-25	<NULL>	<NULL>	6104	Effects of a mat Pilates Method exercise protocol on the mental health and quality of life of university students: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-20	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8xzpdbc	<NULL>	University students regularly enrolled in undergraduate courses in the health area at UFTM, who have attended at least two consecutive terms; Age equal to or greater than 18 years; Not having been pregnant or giving birth in the last six months; Not having had previous contact with the Pilates Method in the last three month.	Having a health problem that makes intervention impossible: musculoskeletal injury, pathology or structural deformity linked to the spine or upper and lower limbs; Systemic disease including rheumatological, metabolic or inflammatory; Present chronic pain at the time of assessment; Having used anxiolytics/antidepressants in the three months prior to the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-69mywb5	Analysis of Dog-Assisted Physiotherapy for children with Cerebral Palsy	Recruitment completed	Intervention	2023-05-25	<NULL>	<NULL>	6105	Dog-Assisted Physiotherapy: structured complementary physiotherapeutic intervention in children with Cerebral Palsy: a single-subject design	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Departamento de Ciências do Movimento Humano - Universidade Federal de São Paulo	Unifesp - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-69mywb5	<NULL>	Children diagnosed with Cerebral Palsy with unilateral or bilateral involvement; both genders; age between 6 and 10 years; classified by the Gross Motor Function Classification System - GMFCS, at levels II or III; having already had contact with dogs in the home, family, friends or neighborhood; being part of a physiotherapy service; do not have surgeries scheduled for the six months following the beginning of the research	Two consecutive or alternating fouls per phase; signs of aversion to the dog or the therapy; dog allergy signs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-10q9pcb7	Acupuncture and reiki in the treatment of Depression and Alcohol or Drug Abuse	Recruiting	Intervention	2023-05-25	<NULL>	<NULL>	6106	Effectiveness of acupuncture and reiki in coping with Depression and Substance Abuse	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-05	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10q9pcb7	<NULL>	Depression: both genders; aged over 18 years; minimum depression score at moderate level on the Depression Anxiety Stress Scale. Substance use disorder: both genders; aged over 18 years; minimum pattern of alcohol risk consumption by the Alcohol Use Disorders Identification Test; moderate problem in the consumption of other drugs by the Drug Abuse Screening Test	Use of medication to treat symptoms of depression or anxiety or alcohol or other drug use; being undergoing psychological treatment; be performing any other alternative practice for the treatment of the symptoms to be treated in the study; not being present in at least six meetings out of the total of eight; refusal to receive the technique in which he was randomly included	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-5fc7f77	Evaluation of the potential of Ozone to whiten teeth without sensitivity	Data analysis completed	Intervention	2023-05-25	<NULL>	<NULL>	6107	Evaluation of the Application of Ozonized Gas in the reduction of post-office bleaching sensitivity - Clinical, randomized and blinded study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5fc7f77	<NULL>	Patients of both sexes, aged between 18 and 35 years; Patients with the presence of all vital anterior teeth, never bleached or restored; Patient with periodontal health; Patients without a history of spontaneous dental pain; Patients who do not use toothpaste with desensitizing properties; Patients willing to return for future evaluations during the research period	Patients with missing anterior teeth, affected by carious lesions, with the presence of recession, with some type of restorative or prosthetic treatment or who use fixed orthodontic appliances; Patient with bruxism or visible enamel cracks; Patients with a history of periodontal disease or active periodontal disease; Patients with a history of dental hypersensitivity; Patients with tooth discoloration due to fluorosis or tetracycline; Patients who use many medications; Pregnant or lactating patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-7z8kn4k	Evaluate the effect of using Virtual Reality on anesthetic induction in children	Not yet recruiting	Intervention	2023-05-25	<NULL>	<NULL>	6108	Use of Virtual Reality in anesthetic induction in children	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-7z8kn4k	<NULL>	Pediatric patients aged 4 to 14 years; both sexes; non-carriers of hearing, visual or cognitive disabilities; who will undergo anesthetic induction	Hearing deficiency; Visual impairment; intellectual disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-8jmj76b	Effects of bioavailable curcumin (Cureit®) supplementation in pre-sarcopenic and sarcopenic patients with gastrointestinal tract cancer	Recruiting	Intervention	2023-05-25	<NULL>	<NULL>	6109	Effects of curcumin supplementation in pre-sarcopenic and sarcopenic patients with cancer of the gastrointestinal tract	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de São Paulo	Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-8jmj76b	<NULL>	Volunteers diagnosed with some type of cancer in the gastrointestinal tract confirmed by biopsy or imaging; both genders; age over 18 years, Performance Status of Eastern Cooperative Oncology Group (ECOG) score less than or equal to 3; SARC-CalF greater than or equal to 11; decreased muscle mass; and/or decreased strength.	Volunteers using the chemotherapy drug Irinotecan; in dietary use of curcumin or supplements with curcuminoids or thermogenic; anticoagulants; presence of acute infection during the protocol; pregnant women; lactating women; cognitive limitations; physical limitations that prevent data collection; diagnosis of liver and kidney pathologies, gastric ulcer; participation in other clinical trials; use of Enteral or Parenteral Nutrition Therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-5kbb4zd	Risk factors for chronic cesarean delivery pain	Recruitment completed	Observational	2023-05-25	<NULL>	<NULL>	8312	Cohort study on the incidence and risk factors associated with the development of Chronic Pain after a Cesarean Section	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-03-13	Maternidade Maria Conceição de Jesus	Secretaria da Saúde do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5kbb4zd	<NULL>	Every pregnant woman in labor admitted to the maternity ward for cesarean delivery	Patient with a history of chronic pain located in the pelvic region; previous cesarean section; patients with difficulty communicating verbally; patients in continuous use of opioids; patients who cannot be contacted after hospital discharge (at least three attempts) to undergo the combined clinical reassessment will be considered as losses in clinical follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:51
RBR-7s755rt	The impacts of Pharmaceutical Care in an emergency unit of a teaching hospital	Recruitment completed	Intervention	2023-05-24	<NULL>	<NULL>	6100	Evaluation of the clinical and economic impact of Pharmaceutical Care in an emergency unit of a teaching hospital	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Faculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7s755rt	<NULL>	18 years of age or older; both genders; hospital admission carried out by the medical clinic team; admission between 12pm on Sunday and 12pm on Thursday; patient not coming from the clinical stabilisation room, polytrauma, COVID bed and respiratory or contact isolation; not being in contact isolation; stay in the sector for at least 24 hours after admission; admission has not occurred more than 48 hours ago; registration in the medical record of at least one medication for continuous use on admission; not being described in the medical record that the patient will be discharged, has an accepted bed or is being requested a transfer bed to another sector other than the internal medicine ward; possibility of collecting information due to the ability to communicate and remember the medications for continuous use, the presence of the list or packaging of medication or the presence of a caregiver to acquire the information; not being described in medical records that there was medication reconciliation conducted by pharmacists in the sector before the survey; patient consent to participate in the study by signing the Informed Consent Form	Give up participating in the research before its end	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-92db3n2	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Not yet recruiting	Intervention	2023-05-24	<NULL>	<NULL>	6101	Evaluation of the gynecological and dermatological acceptability of a health product under normal conditions of use_Glo01.2023	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-14	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Globalpro Cosmeticos Eireli	https://ensaiosclinicos.gov.br/rg/RBR-92db3n2	<NULL>	Women; age: 18 to 59 years; phototype: I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; pregnant or lactating women; participants with a history of allergy to the material used in the study; atopy history; use of vaginal cream; participants with a history of allergy to products in the tested category; recent gynecological surgeries; discharges; immunodeficiency carriers; kidney, heart or liver transplants; active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); topical use with corticosteroids in the experimental area up to 8 days before the start of the study; any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-10gqsbsm	Comparison of the effects of two breathing aids, the high-flow nasal cannula and the venturi mask, on exercise tolerance in lung transplant candidates	Data analysis completed	Intervention	2023-05-24	<NULL>	<NULL>	6102	Comparison of the effects of high-flow nasal cannula and venturi mask on exercise tolerance in lung transplant candidates	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-22	Hospital de Messejana Dr Carlos Alberto Studart Gomes	Hospital de Messejana Dr Carlos Alberto Studart Gomes	https://ensaiosclinicos.gov.br/rg/RBR-10gqsbsm	<NULL>	Lung transplant candidates; both genders; older than 18 years; in initial evaluation for inclusion in a pulmonary rehabilitation program; with oxygen dependency or need for oxygen supplementation during the symptom-limited incremental load test performed before inclusion in the study	Candidates who did not comply with the protocol, because they were absent on the assessment day; candidates who did not present clinical conditions on the day of the test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-7yk5zmx	Effect of Sucupira on pain intensity in people with knee osteoarthritis	Recruiting	Intervention	2023-05-24	<NULL>	<NULL>	6103	Effect of Pterodon Extract on Pain Intensity in People with Osteoarthritis of the Knee: A Randomized Clinical Trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2023-05-15	Universidade Federal do Tocantins	Universidade Federal do Tocantins	https://ensaiosclinicos.gov.br/rg/RBR-7yk5zmx	<NULL>	Patients between 40 and 80 years old will be included; of both sexes; who have a medical diagnosis of knee osteoarthritis, reports of chronic pain (pain for more than three months (TREEDE, 2015; JOHNSON, 2019) due to arthritis; who know how to read and write; and who can maintain telephone contact via mobile phone .	Having some cognitive impairment or psychiatric disorder that prevents the completion of the study questionnaires (self-report); be diagnosed withrheumatoid arthritis, fibromyalgia, kidney failure, liver disease and gout; have sustained a substantial knee injury within the past 6 months, have a history of arthroscopic or open surgery on the index knee within the past 12 months, or plan to undergo such a procedure within the next 3 months, have received corticosteroid injections within the past 3 months, or acid hyaluronic acid in the index knee in the last six months, who are pregnant or breastfeeding, using any medication or experimental device in the 30 days prior to randomization, or who have any disease or major medical condition that prevents the 2-month follow-up established for the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-5d7tcjs	Effect of juçara fruit (Euterpe edulis Martius) intake in damage indicators caused by free radicals, fatigue, and performance in trained cyclists	Terminated	Intervention	2023-05-24	<NULL>	<NULL>	6153	Effect of juçara fruit (Euterpe edulis Martius) intake on oxidative stress biomarkers, fatigue, and performance in trained cyclists: a randomized, placebo-contolled, cross-over, and triple-blind clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Federal de Santa Catarina - UFSC	Universidade Federal de Santa Catarina - UFSC	https://ensaiosclinicos.gov.br/rg/RBR-5d7tcjs	<NULL>	Male; aged between 19 and 45 years; with a history of sports practice for more than 6 months with cycling exercises of at least 6 hours per week or 200 km per week	Smoking; chronic diseases; metabolic disorders; physical disabilities; musculoskeletal injuries; reporting consumption of vitamin and mineral supplements, ergogenic resources (carnitine, arginine, creatine, caffeine, nitrate, beta-alanine, and sodium bicarbonate), use of steroids in the last six months; and use of medications in the previous week	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-3m4p22g	Use of Chitosan hydrogel for Diabetic Foot healing	Recruitment completed	Intervention	2023-05-22	<NULL>	<NULL>	6099	Study of the application of hydrogel based on Chitosan in Diabetic Foot ulcers	<NULL>	1, non-randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2022-09-07	Universidade Estadual da Paraíba	Hospital Universitário Alcides Carneiros	https://ensaiosclinicos.gov.br/rg/RBR-3m4p22g	<NULL>	Individuals over 18 years old. Both sexes. With diabetic ulcers. Grade 0 or 1 classification according to the University of Texas Grading System. 1 to 10 cm2 lesion size. Ulcers can be located in the forefoot, midfoot or lower third of the leg. Availability to go to the service once a week	Infected ulcers. Intolerance to the odor of the dressing. Allergy to the research product used. Lack of continuity of treatment at home. Pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-4hnphgb	A Mindfulness-Based Intervention to strengthen mental health and psychological resources in university students: a randomized controlled trial	Not yet recruiting	Intervention	2023-05-19	<NULL>	<NULL>	6094	Effects of a Mindfulness-Based Intervention on the mental health of Brazilian university students: randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-19	Universidade Cesumar	Universidade Cesumar	https://ensaiosclinicos.gov.br/rg/RBR-4hnphgb	<NULL>	Undergraduate students from Cesumar University; aged ≥18 years;  who wish to participate in the study; who can participate in at least six of the eight sessions of the mindfulness program; and who provide informed consent	Students with severe symptoms of anxiety (GAD-7 equal to or greater than 15), depression (PHQ-9 equal to or greater than 15) and severe mental disorder (self-reported); those who report experience with mindfulness, other meditations or mind-body practices such as yoga in the previous 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-1094jttz	Treatment for Benign Prostatic Hyperplasia, a comparative study between dual pharmacological treatment (Tamsulosin and Finasteride) and a minimally invasive Prostatic Urethral Lift procedure (Urolift)	Recruiting	Intervention	2023-05-19	<NULL>	<NULL>	6095	Prospective, randomized study of Prostatic Urethral Lift versus Combined Pharmacological Therapy for men with LUTS-BPH	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade de São Paulo	Teleflex Inc	https://ensaiosclinicos.gov.br/rg/RBR-1094jttz	<NULL>	Men aged &gt; 50 years, with symptomatic prostate hyperplasia and willing to undergo treatment; International Prostate Symptom Score IPSS ≥ 13; Peak urine flow rate ≤ 12ml/s in a urine volume ≥ 125ml; Prostate volume ≥ 40 cc and ≤ 100 cc and prostatic length ≥ 40 mm and ≤ 100 mm assessed by transabdominal prostate ultrasound	Current urinary retention; Post voiding residue &gt; 250ml; Prostate protrusion index (PPI) ≥ 1cm on transabdominal prostate ultrasound;. Active urinary tract infection at the time of treatment; Procedure for treating previous BPH; Urethral conditions that may prevent insertion and release of the device into the bladder (urethral stenosis, meatus stenosis, bladder neck contracture); Previous pelvic surgery or irradiation; History of neurogenic or atonic bladder; Urinary incontinence; Prostate biopsy within the last 6 weeks; Estimated life expectancy of less than 1 year;;History of prostate or bladder cancer;; PSA &gt; 10ng/ml unless prostate biopsy is negative for cancer; Current macroscopic hematuria; Serum creatinine &gt; 1.8mg/dl or upper tract disease that compromises renal function; Known coagulopathies or use of anticoagulants or antiplatelet agents other than aspirin ≤ 10 mg (unless antiplatelet agents are suspended at least 3 days before the procedure); Use within 4 months of baseline assessment: estrogen, any androgen-suppressing medication, or anabolic steroids.Within 3 months of baseline assessment: 5-alpha-reductase inhibitor; Within 2 weeks of the initial assessment; Alpha-blockers, androgens, gonadotropin releasers, hormone analogues, anticholinergics or cholinergic medication; Medications with phenylephrine, pseudoephedrine or imipramine; Within 6 months of baseline: combination therapy with 5-alpha-reductase inhibitor and alpha-blockers; Within 1 week of baseline, unless documented stable dose for ≥ 6 months: beta-blockers, antidepressants, anticonvulsants, and antispasmodics;Cystolithiasis in the last 3 months;History of prostatitis requiring treatment (antibiotics) in the last year; Other comorbidities that may impact the outcome of the study, such as: severe cardiac arrhythmias not controlled by medication or a pacemaker, congestive heart failure NYHA III or IV, history of uncontrolled diabetes mellitus, significant respiratory disease in which hospitalization may if necessary, known immunosuppression (AIDS, post-transplant, in chemotherapy); Unable or unwilling to complete all required questionnaires and follow-up assessments; Unable or unwilling to sign the informed consent form; Currently enrolled in any other experimental clinical research trials that have not completed the primary endpoint	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-5scd5tm	Telerehabilitation and face-to-face multimodal intervention: Randomized controlled clinical trial in adolescents with Temporomandibular Disorder	Recruiting	Intervention	2023-05-19	<NULL>	<NULL>	6096	Exercises applied on line and  face-to-face multimodal intervention: Randomized controlled clinical trial in adolescents with Temporomandibular Dysorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5scd5tm	<NULL>	Participants aged between 10 and 18 years; be regularly enrolled and attending formal school activities at the chosen educational establishment; presence of Temporomandibular Disorders (TMD) confirmed by the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD)	Participantes who have neurological, respiratory or musculoskeletal disorders that may interfere with any of the assessments; who received physical therapy care in the 3 months prior to the evaluation; history of trauma or dislocation to the face and/or TMJ;  who using an orthodontic appliance (mobile or fixed) or myorelaxant plate; who make use of analgesics, anxiolytics and/or muscle relaxants 24 hours before the evaluation, inability to understand and/or perform the assessment protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-7nt59gn	Early Oral Refeeding for Cancer patients undergoing Bowel Surgery	Not yet recruiting	Intervention	2023-05-19	<NULL>	<NULL>	6097	Early oral refeeding in cancer patients undergoing colorectal surgery: a controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-15	Empresa Brasileira de Serviços Hospitalares	Hospital Universitário Professor Alberto Antunes	https://ensaiosclinicos.gov.br/rg/RBR-7nt59gn	<NULL>	Adults and seniors; both sexes; aged 30 years or older; with a proposal to perform elective colorectal surgery due to colorectal neoplasia	Patients with limited mobility; clinical and/or postoperative complications resulting from surgery performed before the start of this study; hospitalizations for diagnostic procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-867mysf	Responses of Functional Training on Blood Pressure and Physical Fitness of Hypertensive elderly	Recruitment completed	Intervention	2023-05-19	<NULL>	<NULL>	6098	Effects of Functional Training on Ambulatory Blood Pressure and Functional Physical Fitness of Resistant Hypertensive Elderly People: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-30	Instituto Leão Sampaio de Ensino Universitário Ltda	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-867mysf	<NULL>	Seniors of both sexes will be included; aged 60 years or older; sedentary or who have not been practicing any physical activity in the last 6 months; making use of three or more antihypertensive agents in adequate doses and combinations	Elderly people with uncontrolled heart failure will be excluded from the study; parkinson; Alzheimer&apos;s; insanity; physical and visual impairment; morbid obesity (BMI&gt;= 40); cancer; unstable angina; musculoskeletal disorders that limit the performance of exercises; or who do not complete at least 90% of the sessions and fail to perform a functional physical fitness test or ambulatory blood pressure at some point	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:31
RBR-4y22q9z	Preemptive use of drugs improves Endodontic Treatment of symptomatic teeth	Recruitment completed	Intervention	2023-05-18	<NULL>	<NULL>	6088	Effect of preemptive use of a Nonsteroidal Anti-Inflammatory drug and a Corticosteroid on the efficacy of inferior alveolar nerve blockade and postoperative Pain control in Endodontic Treatment of molars with Symptomatic Pulpitis: a randomized double-blind placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	Centro de Pesquisas Odontológicas São Leopoldo Mandic SS	https://ensaiosclinicos.gov.br/rg/RBR-4y22q9z	<NULL>	Healthy patient (American Association of Anesthesiologists - class I); having lower molar diagnosed with irreversible symptomatic pulpitis; aged between 20 and 45 years; both genders; endodontic treatment performed within the interval between 80 and 90 minutes performed in patients who did not take any type of analgesic medication in the 12 hours preceding the endodontic treatment	Patients allergic or intolerant to diclofenacs, dexamethasone, articaine or any other drug/material used in this study; pregnant or lactating women; teeth with periodontal problems or radiographic images suggestive of internal/external resorptions; endodontic treatments not completed in a single session	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-5hs6ry4	Nutrient supplementation to improve the behavior of children with Autism Spectrum Disorder	Recruitment completed	Intervention	2023-05-18	<NULL>	<NULL>	6089	Probiotic and micronutrient supplementation to improve neurobehavior in children with Autism Spectrum Disorder: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-5hs6ry4	<NULL>	Children diagnosed with Autism Spectrum Disorder; Age from 3 to 10 years incomplete	Children who have been supplementing with magnesium, vitamin B6 or probiotics for 6 months or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-6f32c6x	Effects of  a Mindfulness-Based Cognitive Therapy and mood induction procedure on autobiographical memory of non clinical participants	Recruitment completed	Intervention	2023-05-18	<NULL>	<NULL>	6090	Mindfulness, mood and overgeneralization of autobiographic memories	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Instituto de Psicologia da Universidade de Brasília - UnB	Universidade de Brasília - UnB	https://ensaiosclinicos.gov.br/rg/RBR-6f32c6x	<NULL>	Adults without depression diagnose or neurological disorders; age between 18 and 50 years	Beck Depression Inventory (BDI-II) baseline score of 12 or higher; use of drugs that interfere with cognition; mental health diagnose	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-8xk78pd	The approach in understanding the person aiming at a change in knowledge and behavior about the importance of lifestyle in patients with high blood pressure that is difficult to control: Randomized Clinical Trial	Recruiting	Intervention	2023-05-18	<NULL>	<NULL>	6091	The impact of a PsychoBehavioral Intervention Program encompassing Life Habits in Resistant Hypertensive Patients: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-07	Hospital Universitário Professor Edgard Santos	Hospital Universitário Professor Edgard Santos	https://ensaiosclinicos.gov.br/rg/RBR-8xk78pd	<NULL>	50 healthy patients will be prospectively selected; men or women; aged 18 years or older; diagnosed with resistant systemic arterial hypertension; using three or more antihypertensive agents from the angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, loop diuretics, thiazides or potassium-sparing diuretics; for at least 4 weeks prior to screening; with a blood pressure that remains above the desired level (140/90 mmHg); who have a smartphone with the WhatsApp application installed.	Exclusion criteria will be patients with creatinine clearance &lt; 30mmol; hyperkalemia &gt; 5.5 meq/l; patients who will not undergo the recommended laboratory evaluation for the biochemical, urinary determination of sodium, potassium and creatinine; people who don&apos;t want to receive daily motivational messages on WhatsApp;  who have any kind of reading restriction; patients who are pregnant; who were receiving hospice; who had a documented life expectancy of less than 6 months; dementia sufferers diagnosed due to concerns of inability to complete all study activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-86kpdr2	Correlationship between the timed inspiratory effort index and the value of the sequence of four stimulus during the recovery of neuromuscular blockade produced by the rocuronium in anestesia	Recruiting	Observational	2023-05-18	<NULL>	<NULL>	6092	Correlationship between the Timed Inspiratory Effort Index and the value of the Sequence of Four Stimulus during the recovery of neuromuscular blockade produced by the rocuronium in anestesia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Hospital Federal de Bonsucesso	Hospital Federal de Bonsucesso	https://ensaiosclinicos.gov.br/rg/RBR-86kpdr2	<NULL>	both genders; age between 18 and 65 years; physical status American Society of Anesthesiologists (ASA) I to III; patients who will undergo elective surgeries under general anesthesia who do not require a dose of rocuronium maintenance	refusal to participate in the study; pregnancy or suspected pregnancy; presence of neuromuscular diseases, renal dysfunction (assessed by calculating the glomerular filtration rate) or hepatic (CHILD criteria); history or predictors of difficult airway; use of furosemide, aminoglycosides, aminophylin, azathioprine; cyclophosphamide, anti-inflammatory drugs and magnesium; allergy to the drugs used in the study; participants in other clinical studies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-7t7gnjk	A new proposal for Agility Training and Cognitive Training, simultaneously, in community-dwelling older adult	Terminated	Intervention	2023-05-18	<NULL>	<NULL>	6093	Agility Ladder: A new Dual-Task proposal for community-dwelling older adult	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-12-04	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7t7gnjk	<NULL>	"Age equal or superior to 60 years; have a score equal to or higher than 20 points in the mini 
mental state examination (MMSE); walk independently; make available for the participation of a four-month exercise program."	"Physical and / or cognitive impairment to prevent physical exercise; history of heart disease 
e.x. acute myocardial infarction), neurological (e.g. Alzheimer&apos;s disease), psychiatric (e.x. schizophrenia),cerebrovascular (e.i. cerebrovascular accident) or metabolic (e.i., diabetes mellitus I); not comply with a minimum of 90% of the total frequency of activities."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-56w7h2p	Electrical Stimulation in women with Primary Dysmenorrhea	Recruiting	Intervention	2023-05-17	<NULL>	<NULL>	6085	Transcranial Direct Current Stimulation in women with Primary Dysmenorrhea: usability and clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-56w7h2p	<NULL>	Age between 18 and 45 years; medical diagnosis of primary dysmenorrhea according to Guideline No. 34539; mean pain equal to or greater than 4 on the Visual Analogue Scale of Pain; periodic pain of at least 3 menstrual cycles in a row; having a regular menstrual cycle of 28 to 32 days; no pelvic inflammatory disease; history of head trauma, epilepsy, endometriosis, current pregnancy, chronic abdominal pain unrelated to the menstrual cycle; fibroids; inflammatory bowel syndrome; irritable bowel syndrome; major abdominal or pelvic surgery; alcohol dependence; nicotine or drugs,; metallic implant; pacemaker; and chronic urinary tract disease	Severe headache in more than two transcranial stimulation sessions; dizziness or severe migraine in more than two transcranial stimulation sessions; failure to perform 2 or more transcranial stimulation applications	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-7hh489b	Effects of exercise on strength of Colorectal Cancer patients undergoing Chemotherapy	Not yet recruiting	Intervention	2023-05-17	<NULL>	<NULL>	6086	Effects of co-contraction training on neuromuscular, biomolecular, and functional parameters in Colorectal Cancer patients undergoing Chemotherapy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7hh489b	<NULL>	Men and women over the age of 18; diagnosed with colorectal cancer; undergoing chemotherapy treatment; with access to a tablet, smartphone, laptop, or computer with an integrated video camera; and willing to appear on camera during exercise sessions to enable safety monitoring	Diagnosis of cardiovascular disease and neurodegenerative diseases; presenting any other health problem that interferes with the execution of the proposed exercises and evaluations; history of neuromuscular injury in the upper and lower limbs in the last 12 months; not being considered able to participate in the study after medical evaluation; refusing to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-10jjpqy4	Effects of a Health Lecture Program compared with Exercise Classes plus Lectures, delivered through a website, on pain self-efficacy of people with Patellofemoral pain: randomized clinical trial	Recruitment completed	Intervention	2023-05-17	<NULL>	<NULL>	6087	Effects of an Education Program compared to Exercise associated with Education, delivered through an Online Platform, on pain self-efficacy in patients with Patellofemoral pain: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-06	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-10jjpqy4	<NULL>	Age between 18 and 40 years; both genders; unilateral anterior knee pain when performing at least two of the following activities: remaining seated for a prolonged period, squatting, kneeling, running, climbing and descending stairs, jumping and landing; anterior knee pain of insidious onset lasting at least 6 months; worst self-reported pain in the last month of at least 30mm on the 100mm Visual Analogue Scale (VAS)	Self-reported anterior knee pain caused by knee trauma; self-reported history of patellar dislocation or subluxation, meniscal injury, ligament instability, patellar tendinopathy or osteoarthritis in any lower limb joint; having undergone prior physical therapy for the treatment of patellofemoral pain (at least 6 months prior to the study); answer yes to one or more questions on the PAR-Q physical activity readiness questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-3s4mf9y	Importance of the mindfulness technique in reducing levels of shortness of breath and improving the quality of life of patients with Lung Fibrosis	Recruiting	Intervention	2023-05-16	<NULL>	<NULL>	6080	Importance of the Mindfulness technique in reducing dyspnea levels and improving the quality of life of patients with Interstitial Lung Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Hospital das Clínicas da Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3s4mf9y	<NULL>	Patients diagnosed with interstitial lung disease according to international guidelines. Dyspnea (mMRC&gt;1). Aged over 18 years. Being followed up and treated at the  interstitial lung diseaseOutpatient Clinic of the Hospital das Clínicas da Universidade Federal de Minas Gerais	Patients with Interstitial Lung Disease who also have dyspnea due to other causes such as heart failure, cardiac arrhythmia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-4x2hh8b	Effects of infusion of yerba mate (Ilex paraguariensis) in vascular function	Recruitment completed	Intervention	2023-05-16	<NULL>	<NULL>	6081	Effects of Infusion of Yerba Mate (Ilex paraguariensis) isolated or associated with Physical Exercise in Vascular Function	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4x2hh8b	<NULL>	Adults of both sexes aged between 18 and 40 years old	Smokers; individuals with cardiometabolic diseases; use of medications and supplements; with the presence of an injury in the arm	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-3xf7v9k	Effects of functional training and dual task in elderly women with and without chronic low back pain	Not yet recruiting	Intervention	2023-05-16	<NULL>	<NULL>	6082	The effects of Functional Training in asymptomatic elderly women with Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-3xf7v9k	<NULL>	Will be included in the research, women with a clinical diagnosis of nonspecific chronic low back pain, between 60 and 79 years old, with a complaint of low back pain for more than 3 months, a pain level greater than 3 on the numerical pain scale of 11 points and women in the same age group without low back pain and/or other type of chronic pain. Asymptomatic elderly women cannot have chronic low back pain and no episodes of pain in the last three months. Volunteers will also need to have a body mass index (BMI) &lt;30 kg/m2, not have undergone spinal surgery; not exercising regularly; not doing physical therapy or other pain treatment; not to use analgesic, anti-inflammatory, opioid or immunosuppressive medication	Exclusion criteria will be missing one of the assessments, more than 20% of the intervention or presenting any motor impairment (paraplegia, paraparesis, monoplegia, monoparesis, hemiplegia, hemiparesis), psychiatric (schizophrenia, epilepsy, severe depression) or cognitive (moderate mental retardation , severe and/or profound), auditory, visual or communication disorders that make it impossible to carry out the protocol. If there is any suspicion of a disability, the volunteer will be referred for evaluation by a general practitioner and, if confirmed, the participant will be referred to the physiotherapy, speech therapy and/or psychology departments at UFS for proper follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-58hnx64	Clinical performance of Ceramic Dental Crowns	Not yet recruiting	Intervention	2023-05-16	<NULL>	<NULL>	6083	Clinical performance of Zirconia Monolithic Implant-Supported Single Crowns: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-58hnx64	<NULL>	"Volunteers that require tooth replacement with an implant-supported single crown in one posterior quadrant in the maxilla or mandible; age from 18 to 70; good oral hygiene;	periodontal health or successful periodontal therapy; at least one adjacent tooth/restoration; presence of antagonistic contacts"	Volunteers with dental implants exhibiting biologic complications before the fabrication of the definitive implant-supported single crown; severe parafunctional habits; lack of occlusal stability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-6s3bncq	Effects of an intuitive eating-based intervention on behavioral and metabolic responses in overweight and obese adults: a randomized clinical trial pilot study	Recruitment completed	Intervention	2023-05-16	<NULL>	<NULL>	6084	Intervention based on the intuitive eating technique under nutritional counseling: metabolic and behavioral responses in overweight and obese adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6s3bncq	<NULL>	male and female volunteers; between 18 and 59 years old; with a BMI above 25 Kg/m2	pregnant; puerperal women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-3y733pt	Effects of Acupuncture in the treatment of hip pain caused by Osteoarthritis	Terminated	Intervention	2023-05-16	<NULL>	<NULL>	6667	Effects of Acupuncture in the treatment od chronic pain associated with Hip Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-22	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3y733pt	<NULL>	Be over 18 years old; Man or woman; Unilateral diagnosis of hip osteoarthritis according to clinical criteria; Kellgren-Lawrence grade 3 or 4 radiological classification; Failure in conservative treatment consisting of: exercises, pharmacological therapies such as analgesics or anti-inflammatory drugs, use of gait aids or no improvement when performing trigger point blocks; Pain assessed by Visual Analogue Scale greater than four; Previously not treated with acupuncture.	Limitation of understanding of assessment procedures or instruments; Difficulty in clinical follow-up and attendance to reassessments for any reason; Diagnosis of other diseases that limit functionality or assessment of pain in the lower limbs; Painful involvement of other joints of the lower limbs by Osteoarthritis; Have previous hip surgeries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-35q7s3v	Degradation rate of bleaching gels during in-office tooth bleaching	Other	Intervention	2023-05-16	<NULL>	<NULL>	7154	Clinical degradation rate of bleaching gels with different acidities during in-office tooth bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-20	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-35q7s3v	<NULL>	Patients aged 18 years or older; male or female; in good general and oral health; the premolars, canines and incisors of the maxilla and mandible they need to be free of caries lesions, restorations or endodontic treatments; the canines superiors must present WId values ​​lower than 20, evaluated with a digital spectrometer (Vita Easyshade, Vita Zahnfabrik, Bad Säckingen, Germany)	Pregnant or lactating patients; smokers; with bruxism; severe internal discoloration (tetracycline stains, fluorosis, teeth pulped); dentine hypersensitivity; gingival recession or undergoing orthodontic treatment; participants who use anti-inflammatories, analgesics or antioxidants daily; patients who have already undergone tooth whitening procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:10
RBR-3c5f7xt	Model of attention by cell phone application to change the level of Physical Activity in workers	Not yet recruiting	Intervention	2023-05-15	<NULL>	<NULL>	6074	M-Health-mediated care model for changing the level of Physical Activity in workers	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-3c5f7xt	<NULL>	Both genders. Age range above 18 years. Have an employment relationship with the Institution with a workload equal to more than 30h/week, with a face-to-face shift. Own a smartphone with Android version equal to or greater than 7.0. Have an affinity with using apps. Have internet at home (wi-fi) and/or cell phone (mobile data)	Participants who have more than one employment relationship. Participants who are undergoing chemotherapy treatment. Physically active participants and/or regular participants in a physical activity program (&gt;150 min/week)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-107sn9vb	Osteopathy in women with Migraine: a pragmatic randomized controlled clinical trial	Recruiting	Intervention	2023-05-15	<NULL>	<NULL>	6075	Manipulative Osteopathic Treatment in women with Migraine: a pragmatic randomized controlled clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-03	Instituto Docusse de Osteopatia e Terapia Manual S/S Ltda	Universidade de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-107sn9vb	<NULL>	Women; 18 to 55 years old; with the medical diagnosis of migraine without aura, confirmed by the physician (Líliam Estevão da Silva - LSE) who collaborated in the study, according to the diagnostic criteria of the International Classification of Headaches of the International Headache Society (CIC, 2004); patients who present at least two crises and/or  six days of pain per month, who have had the disease for more than one year	History of trauma/fracture to the face and neck; presence of other concomitant headaches; systemic diseases; neuropathies; tumors; volunteers who have injected medication or blockade in the cervical spine in the last 3 months; volunteers who have undergone osteopathy or physiotherapy treatment; do not agree or do not understand what will be explained	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-75yrff5	Effect of Physical Exercise on blood, functional and neurological variables of elderly people with Alzheimer&apos;s Disease	Recruiting	Intervention	2023-05-15	<NULL>	<NULL>	6076	Effect of Multicomponent Training on biochemical, neuropsychiatric, cognitive, functional, and physiological aspects in elderly with Alzheimer&apos;s Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Programa de Pós-graduação em Ciências da Saúde	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-75yrff5	<NULL>	Elderly aged 65 years or older diagnosed with Alzheimer&apos;s	Participants who did not attend at least 70% of the training protocol classes; participants who, during the training, are not in the conditions provided for in the criteria; participants who drop out; present osteoarticular, musculoskeletal, cardiovascular, visual, auditory complications or impairment, vertigo syndrome or other limitations that hinder locomotion, performance of tests and intervention; having other neurodegenerative diseases concomitantly with Alzheimer&apos;s disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-33qh2sy	Bodybuilding and Auriculotherapy as auxiliary treatments during Hemodialysis in patients with Kidney Disease	Data analysis completed	Intervention	2023-05-15	<NULL>	<NULL>	6077	Resistance Physical Exercise and Auricular Acupuncture as treatment tools non-pharmacological in Chronic Renal patients undergoing Hemodialysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-33qh2sy	<NULL>	Included in the study were patients of both genders; aged 18 years or older; who were under medical follow-up due to a diagnosis of chronic kidney disease; on hemodialysis for at least 6 months;	Patients who did not agree to participate in the research; those who died or dropped out; as well as those who were already doing auricular acupuncture and physical exercise outside the research will be excluded; Patients who had less than 75% adherence to the total number of sessions;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-5wk8nvr	Comparison of intraocular lenses with distant and near vision used in Cataract Surgery	Recruitment completed	Intervention	2023-05-15	<NULL>	<NULL>	6078	Comparison of performance of extended depth of focus intraocular lenses	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-25	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5wk8nvr	<NULL>	Patients diagnosed with bilateral cataracts. Absence of other ophthalmological pathologies. Corneal astigmatism of up to 1D. Literate. No age limit. both sexes	Other ocular pathologies. Impossibility of performing the surgery in both eyes. Illiteracy. Astigmatism greater than 1D	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-3q9zb73	Intracranial Aneurysm treatment with a Neurostent trial	Recruiting	Intervention	2023-05-15	<NULL>	<NULL>	6079	Flow modification in the treatment of Distal Intracranial aneurysms using Dual versus Mono-antiplatelet therapy Randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-27	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3q9zb73	<NULL>	Patients between 18 and 80 years old inclusive; Patients with an unruptured aneurysm of one of the following locations: internal carotid artery, middle cerebral artery, anterior cerebral artery, vertebral artery, basilar artery, posterior cerebral artery; Saccular aneurysm measuring ≥ 3 mm in greatest diameter; Neck aneurysm measuring ≥ 3 mm, or dome-neck ratio ≤ 2; modified Rankin Scale (mRS) prior ≤ 3; Patient agrees and signs the informed consent form	Any ischemic or hemorrhagic stroke within the last 90 days; Ruptured aneurysm in the last 90 days; Had major surgery that required general anesthesia in the last 90 days; Known clotting disorder; Use of anticoagulants; Platelet count &lt; 100,000 cells/mm3 or known platelet dysfunction; Contraindication to the use of study drugs; Presence of a previous neurostent next to the aneurysm to be treated; Presence of a previous surgical clip next to the aneurysm to be treated causing any stenosis of the carotid artery; Known severe allergy to iodinated contrast media defined by previous occurrence of bronchospasm, laryngospasm, circulatory shock; Chronic kidney disease defined by serum creatinine &gt; 2.5 mg/dL; Pregnancy, lactation, positive pregnancy test; Modified Rankin scale previous from 4 or 5; Any other medical condition that results in a life expectancy ≤ 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-4n5f5jb	Clinical trial to evaluate the use of the medication Esketamine with intravenous administration in association with the treatment of patients with severe depression who present with hallucinations and delusions	Recruiting	Intervention	2023-05-14	<NULL>	<NULL>	6073	Randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of using intravenous Esketamine as an adjunct in the treatment of Psychotic Unipolar Depression	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal da Bahia	Hospital Universitário Professor Edgard Santos	https://ensaiosclinicos.gov.br/rg/RBR-4n5f5jb	<NULL>	Patient aged between 18 and 65 years, diagnosed with unipolar depression with psychotic symptoms, according to clinical evaluation and diagnostic criteria for unipolar depression of the Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5), evaluated using MINI 7.0.2 (The Mini International Neuropsychiatric Interview), with a score of 20 or more on the MADRS scale at baseline; The assessment of psychotic symptomatology will be performed using item 15 of the BPRS, including patients with scores greater than or equal to 3 (i.e., without belief change after reality testing); The duration of the current depressive episode must be at least 4 weeks.	Patients diagnosed with primary psychotic disorders - such as schizophrenia, schizoaffective disorder, brief psychotic disorder - will be excluded, as well as patients with bipolar affective disorder, current substance use disorder according to DSM-5 criteria; patients in a state of mutism or catatonic stupor; patients with dementia or intellectual disability; pregnant or lactating patients; patients with uncompensated general medical conditions or general medical conditions whose psychotic and/or depressive symptoms may be a direct manifestation; and first-degree family members of investigators. Furthermore, patients with depressive symptoms attributed mostly to other psychiatric diagnoses other than MDD will be excluded, as in the case of patients with severe personality disorders; Patients undergoing treatment with electroconvulsive therapy (ECT) in the current episode will also be excluded; Hypertensive patients who are decompensated and refractory to antihypertensive measures at pre-infusion times will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-105p888f	Preventive correction of fibrinolysis with Epsilon Aminocaproic Acid detected by Thromboelastometry during Liver Transplant	Data analysis completed	Intervention	2023-05-12	<NULL>	<NULL>	6070	Prophylactic correction of fibrinolysis with Epsilon Aminocaproic Acid diagnosed by Thromboelastometry during Orthotopic liver transplantation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-05-01	José Carlos Rodrigues Nascimento	José Carlos Rodrigues Nascimento	https://ensaiosclinicos.gov.br/rg/RBR-105p888f	<NULL>	Patients undergoing liver transplantation; both sexes; age from 18 years	Patients with contraindications to antifibrinolytic therapy; such as disseminated intravascular coagulation; bacteremia; portal thrombosis; Budd-Chiari syndrome; neoplasia; autoimmune hepatitis; acute or chronic renal failure; those who refused to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-10jcg95y	Assessment of metabolic changes as predictors and follow-up effectiveness Pre-surgical Speech Therapy in the prevention of Swallowing and Voice Changes after Anterior Cervical Spine Surgery	Recruitment completed	Intervention	2023-05-12	<NULL>	<NULL>	6071	Assessment of predictive metabolic factors and Speech Therapy Pre-surgical Protocol efficacy in the prevention of Dysphagia and Dysphonia after Anterior Cervical Arthrodesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	https://ensaiosclinicos.gov.br/rg/RBR-10jcg95y	<NULL>	All patients with indication for performing anterior cervical arthrodesis during the period of study	Review performance surgery or previous surgery in the cervical region; previous neurological diseases; diagnosis of previous gastroesophageal reflux; previous dysphagia and dysphonia; evolution to framework tetraparesis or tetraplegia after the surgical procedure; postoperative tracheostomy; failure due to implant breakage or loosening of screws and/or intersomatic devices; not available for video call	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-4wjqxcv	Carbohydrate Reduction and Exercise in women with Polycystic Ovary Syndrome	Recruiting	Intervention	2023-05-11	<NULL>	<NULL>	6067	Low-carbohydrate Diet and Endurance Exercise for women with Polycystic Ovarian Syndrome: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (Fapesc)	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-4wjqxcv	<NULL>	Women between 18 and 50 years old diagnosed with polycystic ovary syndrome	Pregnant; lactating; climacteric women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-7y2gbdf	Experiment for the treatment of Leishmaniasis of the skin with two drugs, Pentamidine and Tamoxifen	Recruitment completed	Intervention	2023-05-11	<NULL>	<NULL>	6068	Treatment of American Tegumentary Leishmaniasis due to Leishmania (Viannia) guyanensis with a combination regimen of Pentamidine and Tamoxifen. Randomized clinical trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-10-21	Silmara Navarro Pennini	Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta	https://ensaiosclinicos.gov.br/rg/RBR-7y2gbdf	<NULL>	Aged from 18 to 65 years; diagnosis of Cutaneous Leishmaniasis confirmed by direct parasitological examination; with a maximum of six lesions; without previous treatment	Women of childbearing age not using contraceptives; pregnant; lactating women; patients who had already had leishmaniasis; presence of comorbidities; patients under treatment with immunosuppressants or drugs that prolong the QT interval; patients with difficulties in attending planned visits in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-83tdxm4	Impact of Parental Coaching on the development of early childhood children with warning signs for Autism Spectrum Disorder	Data analysis completed	Intervention	2023-05-11	<NULL>	<NULL>	6069	Effectiveness of parental coaching model on the development of social communication and behavior patterns of early childhood children at risk for Autism Spectrum Disorder: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-10	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-83tdxm4	<NULL>	Children with warning signs for Autism Spectrum Disorder with scores greater than 7 on the M-CHAT-R/F; both genders; age range from 16 to 30 months; parents/caregivers willing to participate in the study	Children with extreme prematurity and low birth weight; presence of motor, physical alteration and/or identification of genetic syndrome in the child	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:30
RBR-7wwjrq3	Effectiveness of an early intervention program by telehealth for infants at high risk of Cerebral Palsy	Not yet recruiting	Intervention	2023-05-10	<NULL>	<NULL>	6065	Effectiveness of a goal-oriented collaborative early intervention program (early together) by telehealth for infants at high risk of Cerebral Palsy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7wwjrq3	<NULL>	Infants born at term or preterm aged three to five months corrected age for preterm infants and three to five months of chronological age for term infants at high risk of cerebral palsy	Children with clinical instability, tracheostomy or oxygen dependents	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-3pvdvfk	Effects of two types of exercise on shoulder pain, function and muscular control in individuals with shoulder tendinitis	Recruiting	Intervention	2023-05-10	<NULL>	<NULL>	6066	Isometric versus isotonic exercise in individuals with rotator cuff tendinopathy - effects on shoulder pain, function, and neuromuscular control: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3pvdvfk	<NULL>	individuals aged between 18 and 60 years, with shoulder pain for at least three months; at least one positive specific test in physical exam (Jobe test or resisted external rotation); and diagnosed with tendinopathy by an orthopedist through confirmed morphological alterations in the rotator cuff tendons (supraspinatus and/or infraspinatus) observed using nuclear magnetic resonance or ultrasonography	individuals that perform high-intensity sports with high shoulder demand; impaired long head of biceps; adhesive capsulitis; history of glenohumeral luxation or subluxation; history of clavicle, scapula, or humerus fracture; history of rotator cuff surgical intervention; signs of partial or complete rupture of  rotator cuff; acromioclavicular joint osteoarthritis; neurologic or rheumatologic dysfunctions; corticoid application at least three months before the baseline evaluation; body mass index&gt;28 kg/m2 since it may compromise quality of electromyography data; and individuals under treatment with fluoroquinolone antibiotics or diabetes because both may affect tendon metabolism.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-62zs73b	Evaluation the 3d simulation in Breast Cancer patients	Recruitment completed	Intervention	2023-05-08	<NULL>	<NULL>	6058	"Evaluation of the effectiveness and feasibility of 3D image simulation in patients who
will be underwent to Mastectomy with Implant Reconstruction"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Positivo	Hospital Nossa Senhora das Graças	https://ensaiosclinicos.gov.br/rg/RBR-62zs73b	<NULL>	Breast cancer patients with carcinoma in situ or invasive carcinomas undergoing oncology surgery following breast reconstruction or oncoplastic surgery	Patients who refused and could not complete six month follow-up; who underwent prophylactic mastectomy or preoperative radiotherapy; those who had local recurrence or metastasis at the time of analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-68tfqj2	The influence of the use of Periodontal Guides on the predictability of the esthetic procedure of increasing the tooth exposed area through the Crown Lengthening Technique	Recruiting	Intervention	2023-05-08	<NULL>	<NULL>	6059	The influence of the Guided Technique on the predictability of Esthetic Crown Lengthening procedures	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-13	Faculdade de Odontologia de Araraquara (Universidade Estadual Paulista)	Faculdade de Odontologia de Araraquara (Universidade Estadual Paulista)	https://ensaiosclinicos.gov.br/rg/RBR-68tfqj2	<NULL>	Complaint of gummy smile with altered passive eruption; age range between 18 and 40 years	Patients who underwent irradiation in the head and neck region; patients with immunosuppression and immunosuppression; patients who use or used anti-resorptive drugs or who alter bone metabolism; patients with poor oral hygiene; pregnant or lactating women; patients with uncontrolled diabetes; smokers and patients with unrealistic expectations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-10dv8yp2	Dexamethasone and Paracetamol with Codeine in Pain Control of Acute Dental Abscess: a randomized clinical trial	Not yet recruiting	Intervention	2023-05-08	<NULL>	<NULL>	6060	Dexamethasone and Paracetamol with Codeine in Pain Control of Acute Dentoalveolar Abscess in Evolution: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-10dv8yp2	<NULL>	Patients aged 18 to 55 years; diagnosis of acute dentoalveolar abscess in evolution; pain score equal to or greater than 40 mm in the Visual Analog Scale, at the time of initial care	Patients allergic to the drugs used in the present study; chronic use of opioids, steroid anti-inflammatories, antidepressants; history of liver disease; rheumatoid arthritis; severe heart disease; diagnosis of depression/anxiety; pregnant or lactating women; alcoholics; current or former users of substances such as crack, oxy, cocaine, marijuana and solvents; chronic pain; difficulties in understanding the scales	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-9y9p68g	Effect of Electrostimulation on swallowing biomechanics after Radiotherapy	Recruiting	Intervention	2023-05-08	<NULL>	<NULL>	6061	Effect of Electrostimulation on swallowing biomechanics after Radiotherapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Irmandade Santa Casa de Misericórdia de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9y9p68g	<NULL>	Adult individuals over 18 years of age; diagnosed with head and neck cancer; submitted to radiotherapy in the head and neck region, with or without associated chemotherapy and/or surgery; having finished the radiotherapy and presenting skin integrity and medical clearance to use the technique	Patients with contraindications for electrical stimulation: skin alterations in the region where the electrotherapy will be applied, use of a pacemaker or any other devices or alterations that make electrical stimulation impossible; with an active tumor in the region that will receive electrical current	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-7kxf2k4	Kojic Acid Serum and Microneedling in the treatment of Melasma	Recruitment completed	Intervention	2023-05-08	<NULL>	<NULL>	6062	Treatment of Melasma: development and evaluation of a Topical Formulation containing Kojic Acid associated with Microneedling	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Faculdade de Farmácia da Universidade Federal do Rio de Janeiro	Unidade de Farmácia da Universidade do Estado do Rio de Janeiro Campus Zona Oeste	https://ensaiosclinicos.gov.br/rg/RBR-7kxf2k4	<NULL>	Female participant; participant between 25 and 60 years old; with melasma	Skin infection; an inflammatory process in the skin; cancerous lesions; psoriasis; active acne; active herpes; autoimmune disease; clotting disorders; using anticoagulant; in chronic use of anti-inflammatory drugs; using isotretinoin; in other procedures; allergic to any asset used; history of hypertrophic; history of keloid scarring; pregnancy; breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-4ngnx3b	Nerve Stimulator implantable to ameriolate Erectile Function in men living with Spinal Cord Injury	Not yet recruiting	Intervention	2023-05-08	<NULL>	<NULL>	6063	Safety and Tolerability of a novel implantable Nerve Stimulator to ameliorate Erectile Function: a first study in men living with Spinal Cord Injury	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	E Pizolato Preparacao de Documentos e Servicos Especializados de Apoio Administrativo	Fundação do ABC	https://ensaiosclinicos.gov.br/rg/RBR-4ngnx3b	<NULL>	Men; 18 to 55 years old; traumatic spinal cord injury; injury less than 1 year ago; treat erectile dysfunction; responsive to PDE5 inhibitors; IIEF-15 score is equal to or less than 25 points.	Spinal injury at T6 or above; history of autonomic dysreflexia; known allergies to any device material (Platinum/Iridium, Silicone, Pellethane, Titanium, Polysulfone, Polyurethane); contraindicated for surgery under general anesthesia; PSA greater than 4.0ng/mL; priapism or Peyronie&apos;s disease; hypertension; previous pelvic surgery; irradiation therapy; current use of an implantable penile device; diagnosed with a progressive degenerative neurological disease that can negatively impair erectile function; diabetes mellitus suffering from peripheral neuropathy or other complications associated with diabetes; not interested in sexual activity; currently participate in other clinical investigations; depression or abnormal behavior; IIEF-15 score equal to or greater than 26 points; high risk of prostate cancer, as determined by a positive PSA test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-103674zd	Effect of periodontal dressing on healing of gum removal procedure	Recruiting	Intervention	2023-05-07	<NULL>	<NULL>	6057	Effect of periodontal dressing on gingivectomy healing	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-103674zd	<NULL>	18 years or older; In good general and oral health; Present indication for gingivectomy/gingivoplasty in the anterior region; Consent to participate in the research	Patients who smoke; patients who consume drink alcohol; Use fixed orthodontic appliance; Frequent use of phenytoin, nifedipine or cyclosporine; Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-10h5gd44	Use of Scintigraphy in the evaluation of the response to Renal Denervation in patients with treatment-resistant hypertension	Data analysis completed	Intervention	2023-05-05	<NULL>	<NULL>	6055	Use of Metaiodobenzylguanidine-123 Scintigraphy in the evaluation of the response to Renal Sympathetic Denervation in patients with treatment-resistant hypertension	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2018-03-01	Instituto Dante Pazzanese de Cardiologia	Instituto Dante Pazzanese de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-10h5gd44	<NULL>	treatment resistant hypertension; age between 18 and 75 years old	Secondary hypertension; advanced chronic renal failure (creatinine clearance &lt; 30 ml/min); abnormal renal vascular anatomy (diameter less than 3 mm; extent less than 20 mm; or stenosis greater than 30%); allergic reaction to the iodine contrast; pregnant women; unable to understand the study or sign the consent form; patients with decompensated heart failure; hemorrhagic diathesis; consumptive diseases; severe peripheral arterial obstructive disease; acute diseases such as coronary and cerebrovascular syndromes were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-8g2q8q5	The effect of Cannabinoids on Oral Mucositis during Cancer treatment	Recruiting	Intervention	2023-05-05	<NULL>	<NULL>	6056	The use of Cannabinoids and Photobiomobulation therapy in the prevention and control of radio-induced Oral Mucositis in patients with Head and Neck Cancer: A randomized controlled clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-02-07	Universidade Federal de Goias	Associação de Combate ao Câncer de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-8g2q8q5	<NULL>	"The study will include participants over 18 years of age; of both sexes; of any ethnicity; skin color; race; edentulous or not; with primary diagnosis of squamous cell carcinoma in the head and neck region; oral cavity; oropharynx; nasopharynx and larynx. Tumors should be classified into T3/N1; T3;N2 or T4 with N1; state N2 or N3; patients should also be indicated for RT, with or without chemotherapy; with a total dose of TR &gt; 50Gy and daily minimum of 2Gy without history of previous RT in the region of interest or previous CT.
Sociodemographic variables; like sex; age; skin color; ethnicity; marital status; city where you live; urban or rural sector; schooling; family history of cancer and occupation will be noted. Besides these; risk factors such as occupational exposure; alcoholism and smoking habits will also be recorded Sociodemographic variables, such as: sex, age, skin color, ethnicity, marital status, city where they live, urban or rural sector, education, family history of cancer and occupation will be pointed out. In addition to these, risk factors such as: occupational exposure, alcoholism and smoking habits will also be recorded."	Patients with tumors in salivary glands; patients with Sjögren&apos;s syndrome; patients with infectious diseases; individuals who will undergo palliative RT or with a history of previous cancer treatment. Individuals diagnosed with lymphoma; melanoma or skin cancer will also be excluded from the sample. In cases of death; withdrawal; If five or more consecutive TFBM sessions are missed, participants will also be excluded from the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-9rydqwx	Evaluation of the effect of Ozone Therapy on the perception of pain, swelling and difficulty opening the mouth in the postoperative period of Surgery to Remove a mandibular wisdom tooth	Not yet recruiting	Intervention	2023-05-04	<NULL>	<NULL>	6051	Evaluation of the effect of Ozoniotherapy on the perception of pain, edema and post-operative trismus in Dental Extraction of third mandibular molars: a double-blind randomized clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-15	Livia Bonjardim Lima	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9rydqwx	<NULL>	Patients aged between 18 and 30 years. No impairment of general health as per medical history (healthy). Normal physical examination. Patients who agree to participate in the study. Patients with indication for bilateral extraction of mandibular asymptomatic third molars. Third molars in class IIB position, according to the Pell &amp; Gregory classification	History of use of any type of analgesic, anti-inflammatory and antibiotic medication in the 15 days prior to the beginning of the surgical procedure. History of hypersensitivity to drugs, substances or materials used in this experiment. Pregnancy or lactation. Pericoronitis or other local infection within 15 days prior to the surgical procedure. History of systemic disease, such as hypertension, diabetes, or diseases with high oxidative stress, such as favism, severe anemia. Shortest intervention time less than 75% of the time elapsed in the longest intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-9hk6pgz	Benefits of Physical Exercise for older adults with Obstructive Sleep Apnea	Not yet recruiting	Intervention	2023-05-04	<NULL>	<NULL>	6052	Obstructive Sleep Apnea treated with Exercise and Inspiratory Muscle Training: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9hk6pgz	<NULL>	Age between 60 and 79 years; both genders; moderate to severe Obstructive Sleep Apnea, with an apnea-hypopnea index greater than 15 events per hour; no history of previous or current Obstructive Sleep Apnea treatment; and no other sleep disturbance than Obstructive Sleep Apnea	Use sleeping medications; have engaged in physical exercise within the past six months; have contraindications (cardiovascular, respiratory, musculoskeletal, or neurological) for exercise; or have cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-863mw5z	Study on the effects of Tranexamic Acid on death and the need for blood during surgery in children operated on for Brain Tumors	Recruiting	Intervention	2023-05-04	<NULL>	<NULL>	6053	Effects of Tranexamic Acid on mortality and transfusion rate in children undergoing Central Nervous System Tumor Resection Surgery: randomized, double-blind, placebo-controlled clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-04-24	Universidade Federal de São Paulo	Grupo de Apoio ao Adolescente e à Criança com Câncer	https://ensaiosclinicos.gov.br/rg/RBR-863mw5z	<NULL>	Patients from both genders; younger than 18 years old with a diagnosis of central nervous system tumor, characterized by radiological imaging (tomography or magnetic resonance imaging); whether it&apos;s their first surgery or reoperation due to relapse or progression; preoperative hemoglobin greater than 10mg/dl	Patients over 18 years of age; patients with tumors in sites other than the intracranial compartment; patients with a history of hematological, liver, kidney, vascular diseases or who have had a previous thromboembolic event; patients who refuse to participate voluntarily will be excluded from the study; patients with epilepsy refractory to anticonvulsant medication (defined as the presence of seizures in a period of less than 12 months in patients with at least two anticonvulsants in an optimized dose); patients with tumors with a volume greater than 50% of a cerebral hemisphere	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-8rmv3n6	Effects of Body Weight Training on blood components, functional capabilities and blood pressure in Hypertensive elderly women	Recruitment completed	Intervention	2023-05-03	<NULL>	<NULL>	6048	Effects of Calisthenics Training on biochemical, functional and hemodynamic aspects in Hypertensive elderly women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8rmv3n6	<NULL>	Women aged between 60 and 75 years; vaccinated against COVID-19; duly medicated hypertensive patients; non smokers; with a BMI below 32 kg/m²; non-practitioners of physical exercise on a regular and systematic basis for at least three months; without musculoskeletal problems or cardiovascular complications (besides hypertension) that prevent the practice of systematic physical exercises; no diagnosis of Type I Diabetes Mellitus or lung disease; with medical evaluation involving a clinical anamnesis and medical certificate releasing the participation in a training program with physical exercises	Mulheres não vacinadas contra COVID-19; hipertensas não-medicadas; fumantes; com IMC acima de 32 kg/m²; praticantes de exercícios físicos de forma regular e sistemática; com problemas osteomusculares ou complicações cardiovasculares impedindo a prática de exercícios físicos sistemáticos; com diagnóstico de Diabetes Mellitus tipo I ou doença pulmonar; sem avaliação médica envolvendo uma anamnese clínica e atestado médico liberando a participação em um programa de treinamento com exercícios físicos	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-44nrnjz	Oral health literacy and behavioral factors and their association with oral conditions in preschool children	Not yet recruiting	Intervention	2023-05-03	<NULL>	<NULL>	6049	Oral health literacy and parental psychosocial factors and their association with oral conditions in preschool children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-05	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-44nrnjz	<NULL>	Volunteers over 18 years of age; who stays with the child most of the time; both sexes; who have Brazilian Portuguese as their native language; Children aged between 4 completed years and 5 years 11 months and 29 days; enrolled in the Municipal School of Early Childhood Education Tijucas do Sul	Volunteers over 80 years of age; with reported vision or hearing problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-6qvdftm	Crowns on ceramic implant with experimental glass: study of its clinical behavior	Recruiting	Intervention	2023-05-02	<NULL>	<NULL>	6044	Clinical influence of functional gradation with glass on implant-supported zirconia crowns: evaluation of wear, color stability and degradation at low temperature	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-21	Universidade Federal do Rio de Janeiro	Instituto de Ciência e Tecnologia de São José dos Campos	https://ensaiosclinicos.gov.br/rg/RBR-6qvdftm	<NULL>	Patients between 18 and 70 years of age, of both sexes; Patients who are missing 1, up to 2 molars and/or premolars with an indication of receiving osseointegrated implants;The opposing tooth must be sound or with a small restoration (occlusal isthmus of a maximum occlusal 1/3); There must be the presence of collateral teeth to the implant without proximal restorations; Signing of the Free and Informed Consent Term (TCLE) for participating in the research, after explaining the risks and benefits (Resolution No. 196 of October 1996 and the Dental Professional Code of Ethics – C.F.O. - 179/93)	Severe periodontal disease, caries disease and poor oral hygiene; Patient without antagonist tooth or with removable prostheses; Patient with the opposing tooth to the restored implant; Missing posterior tooth; Patient with comorbidities that contraindicate implant surgery; Pregnant and lactating patients; Patients who make continuous use of corticoid anti-inflammatory drugs; Antibiotic therapy in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-3hnmbdt	Dermatological test on revitalizing lotion and restorative lotion	Not yet recruiting	Intervention	2023-05-02	<NULL>	<NULL>	6045	Assessment of primary and cumulative irritation potential and sensitization potential from the skin supervised by a dermatologist to the investigational products lotion revitalizing and restorative lotion	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-06-15	Kosmoscience Ciência e Tecnologia Cosm Imp Exp Ltda	Universidade São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-3hnmbdt	<NULL>	Healthy research participant; age range between 18 and 70 years; both sexes; phototype (Fitzpatrick): I to IV; agree to adhere to the requirements of the study in combating the COVID-19 pandemic, through preventive measures: use a mask as recommended by the WHO; use the mask while traveling to the research center and during study procedures; maintain social distancing; frequently wash your hands with soap and/or alcohol gel and attend the research center only at scheduled times to avoid crowds; agreement not to wet the site during the entire test period; understand the test procedures and agree to adhere to the study requirements; absence of inflammatory dermatoses or tattooing at the application site; signature of the Free and Informed Consent Term (TCLE)	Gestation; lactation; participants who have hyperthermia (body temperature greater than or equal to 37.5°C); participants who have been diagnosed with COVID-19 by RT-PCR test or by the presence of IgM antibodies in the serology test, in the last 4 weeks or who are showing the following symptoms: dry or productive cough, sneezing, runny nose, body pain , headache, anosmia (loss of smell), ageusia (loss of taste) and/or any other symptom that may be related to covid-19 at the discretion of the investigator; participant who belongs to the risk group for COVID-19, that is, with chronic cardiovascular, renal and respiratory problems, immunosuppression or other conditions that the doctor judges as belonging to the risk group; participants with heart diseases (for example, but not limited to: atrial fibrillation, obstructive coronary artery disease); participants with kidney and/or neurological diseases; participants with severe or decompensated pulmonary and/or respiratory diseases; use of corticoids, antihistamines and/or anti-inflammatories; presence of localized or generalized dermatological diseases; presence of active inflammatory dermatoses in the test region; frequent exposure to the sun or tanning beds; having participated in an allergenicity study within a period of less than four weeks from the start of the study; research participants with a history of allergy to the material used in the study; history of atopy; history of pathologies aggravated or triggered by ultraviolet radiation; people with immunodeficiencies; prediction of intense sun exposure or tanning session during the study period; plan to take a bath in the sea, pool or sauna during the study; research participants who practice water sports; survey participants with dermographism; use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticoids up to 2 weeks before selection; vitamin A acid treatment and/or its derivatives orally or topically up to 01 month before the beginning of the study; body aesthetic and/or dermatological treatment up to 03 weeks before selection; prediction of vaccination during the study or up to 03 weeks before the study; any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study; history of non-adherence or unwillingness to adhere to the study protocol; professionals directly involved in carrying out this protocol and their families; currently participating in another study; any condition that, in the opinion of the researcher, could compromise the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-3x8py3n	Evaluation of the effect of Diaphragmatic Breathing on clinical and functional outcomes in children and adolescents with Asthma: a randomized controlled trial	Recruiting	Intervention	2023-05-02	<NULL>	<NULL>	6046	Evaluation of the effect of Breathing Diaphragmatic in the autonomic balance and in the other functional and clinical outcomes in children and adolescents with chronic asthma: a randomized clinical trial and controlled	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-10	Programa de Pós-graduação em Ciências da Saúde	Programa de Pós-graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3x8py3n	<NULL>	partially controlled asthma; uncontrolled asthma	bronchopulmonary dysplasia; cystic fibrosis; congenital cardiopulmonary diseases; immunodeficiency; chronic encephalopathy; psychomotor deficiencies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-6gmrmbm	Effect of the use of Orthoses on walking of children and adolescents with Charcot-Marie-Tooth	Recruiting	Intervention	2023-05-01	<NULL>	<NULL>	6043	Effect of the use of Assistive Technology Devices on the gait of children and adolescents with Charcot-Marie-Tooth: clinical trial	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-27	Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6gmrmbm	<NULL>	Participants aged 3 to 18 years, with a medical diagnosis of CMT any subtype; presenting independent deambulation ability; clinical impairment of the distal lower limbs with postural alterations in the feet, identified by the Foot Postural Index or plantar pressure analysis, muscular strength of the dorsiflexors and/or plantar flexors less than 3 in the manual test; and who accept and sign, together with their legal guardians, the Terms of Consent and Informed Consent.	Participants diagnosed with diabetic polyneuropathy; those with a history of surgery or trauma to the lower limbs in the six months prior to the evaluation; and those who do not understand the commands offered by the evaluator.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-7y8r4tz	Effects of one session of presential and remote strength exercises on pain and health aspects of pregnant women	Recruitment completed	Intervention	2023-05-01	<NULL>	<NULL>	6426	Effects of in person and remote strength training session on pain and health parameters of pregnant women: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7y8r4tz	<NULL>	Women; healthy; age between 18 and 45 years; gestational age between 12 and 35 weeks; be performing prenatal care; to be clinically able to carry out the different training programs proposed in the study; have a medical certificate for the practices; have internet access and devices that allow video connection; having availability of own displacement to carry out face-to-face sessions; not being involved in any systematic physical training program in the last three months; reporting low back pain during pregnancy	Present absolute contraindication to the practice of exercises proposed during the study, according to criteria established by the American College of Obstetricians and Gynecologists (ACOG)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:43
RBR-3xdbk9q	Evaluation of the effect of Low Intensity Laser after Gingival Correction Surgeries	Data analysis completed	Intervention	2023-05-01	<NULL>	<NULL>	6918	Postoperative clinical evaluations of Low Intensity Laser in Gingival Smile Corrective Surgeries	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-28	Fundação Universidade de Pernambuco	Fundação Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3xdbk9q	<NULL>	Patients of both sexes; over eighteen years of age; diagnosis of periodontal health on clinical examination; gingival exposure of three millimeter or more when smiling and surgical indication of at least two teeth in each hemiarch; patients without occlusal discrepancies and or premature contacts; individuals who underwent periodontal surgery or orthodontic treatment more than three months ago	Smokers and or alcohol drinkers; women who are pregnant or breastfeeding; patients requiring additional surgical, restorative and rehabilitative procedures that could influence the measurements performed in the study; patients with a history of maxillofacial cancer in the last five years; patients with uncontrolled systemic conditions; need for treatment due to infection; patients who make chronic use of antiinflammatories, analgesics or psychotropic drugs; patients who are allergic or have some idiosyncrasy to any component of the drugs used in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-106fywbx	Eating behavior and body image of adolescents participating in Mindfulness-based interventions	Not yet recruiting	Intervention	2023-04-29	<NULL>	<NULL>	6042	Eating behavior and body self-image of adolescents participating in Mindfulness-based interventions: a mixed methods study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-106fywbx	<NULL>	Age 15 to 19 years old	Evidence of severe depressive traits, anxiety, or stress, verified through the SCAS-BRASIL scale; Severe cognitive impairment, described through medical diagnosis; Presence of an eating disorder (anorexia, bulimia, binge eating disorder), described by medical diagnosis; Physical impairment that makes it difficult to perform the tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-6xbgv9j	Initial Coagulation Markers in Patients with Kala-Azar Associated with Tranexamic Acid	Not yet recruiting	Intervention	2023-04-28	<NULL>	<NULL>	6038	Early Coagulation Markers in patients with Visceral Leishmaniasis associated with Tranexamic Acid	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Instituto de Doenças Tropicais Nathan Portela - IDTNP	CIATEN - Centro de Inteligência em Agravos Tropicais Emergentes e Negligenciados	https://ensaiosclinicos.gov.br/rg/RBR-6xbgv9j	<NULL>	Patients with confirmed visceral leishmaniasis; both genders; without age restrictions, who agree to participate voluntarily by signing the Free and Informed Consent Term and the Minor&apos;s Assent Term, in patients aged between six and 18 years	Patients using anticoagulant or antiplatelet medication at the time of admission; recent diagnosis or history of thrombosis at any vascular site; congenital or acquired hemostasis disorders; need for dialysis, surgery or an invasive procedure; known or suspected hypersensitivity to any study drug; recent or past history of seizures; history of dengue fever or Severe Acute Respiratory Syndrome Coronavirus 2 infection in the last 30 days; having received specific anti-Leishmania treatment in the last 90 days; having received antifibrinolytic treatment in the last 48 hours or blood products in the last 360 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-24db7p7	Effects of firefighting simulation on mental performance and functions of blood vessels and heart rate	Recruitment completed	Intervention	2023-04-28	<NULL>	<NULL>	6039	Effects of firefighting simulation on cognitive performance and vascular and autonomic functions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-27	Universidade Federal de Santa Catarina	Corpo de Bombeiros Militar de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-24db7p7	<NULL>	Firefighters with at least 3 years of experience who are taking the sergeant training course; both genders; minimum age 18 years	People with cardiovascular disease; mental disorders; metabolic diseases; infectious diseases; inflammatory diseases; muscle injuries; joint injuries; smokers; taking medicines	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-8bmjpd4	Evaluation of the effects of afternoon bright light exposure on sleep and occupational performance of elderly people undergoing hemodialysis	Recruiting	Intervention	2023-04-28	<NULL>	<NULL>	6041	Evaluation of sleep quality of sleep quality and the effects of exposure to afternoon light on occupational performance of patients with Chronic Kidney Disease on Hemodialysis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-10	Universidade de Fortaleza	Universidade de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-8bmjpd4	<NULL>	olunteers aged at least 60 years; diagnosis of End-stage Chronic Kidney Disease in Hemodialysis; of both sexes	Elderly people with severe visual loss; difficulty in clinical follow-up; the use of medications with photosensitizing potential such as imipramine, hypericum, phenothiazines, lithium, chloroquine, hydrochlorothiazide, or tetracycline will be excluded; dementia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-105fptdt	Evaluation of the use of Music in Pain, Anxiety and Quality of life in lower third molar (cis) surgeries: Clinical Trial	Recruiting	Intervention	2023-04-26	<NULL>	<NULL>	6035	Evaluation of effects on Pain, Anxiety and Quality of life of Music therapy in lower third molar removal Surgeries: Randomized, Double-blind and Prospective Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-30	Centro Universitário Christus - UNICHRISTUS	Centro Universitário Christus - UNICHRISTUS	https://ensaiosclinicos.gov.br/rg/RBR-105fptdt	<NULL>	Individuals with impacted mandibular third molars that present in panoramic radiography similar patterns of root formation; position and degree of impaction when comparing the right and left sides of each volunteer	Smokers; pregnant or lactating women; patients with orthodontic bands on mandibular second molars; signs of any preoperative inflammatory or infectious condition; systemic diseases; neurological disorders; patients without hearing or with auricular disorders related to the interpretation of sounds (sound frequencies); which may influence the outcomes of the present study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-10hvfd58	Development of a Treatment Program for people with Binge eating and overweight or Obesity	Recruitment completed	Intervention	2023-04-26	<NULL>	<NULL>	6036	Development of an improved and accessible Treatment Program for people with Binge eating disorder and co-morbid overweight or Obesity	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10hvfd58	<NULL>	Age greater than or equal to 18 years; binge eating disorder according to DSM-5 criteria; body mass index between 27 and 45 kgm2; able to read and write; access to a computer with internet; access to a private room to participate in the online therapy sessions; and access to a scale and stadiometer to measure body weight and height	Bariatric surgery in the previous 24 months; currently receiving any other treatment for weight loss/binge eating; clinical conditions that interfere with weight control e.g., Prader-Willi Syndrome, Cushing Syndrome; being pregnant; and severe psychiatric disorder i.e., schizophrenia, bipolar disorder or a high suicide risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-23mr7yy	The effect of pain education on outcomes after surgery	Recruiting	Intervention	2023-04-26	<NULL>	<NULL>	6712	Impact of Pain Education on postoperative outcomes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-06	Universidade de Brasília - Faculdade de Ceilândia	Universidade de Brasília - Faculdade de Ceilândia	https://ensaiosclinicos.gov.br/rg/RBR-23mr7yy	<NULL>	Age equal to or greater than 18 years and less than 60 years; Both sexes; Patients undergoing elective surgery admitted to the unit	Patients with inability to understand and / or answer questions and questionnaires; Patients who do not accept the terms of participation of the study; Continuous use  over e months of analgesic, anti-inflammatory and antidepressant medications in the preoperative period; People with history of pain for a period greater than 3 months in the preoperative period; Comorbidities: neuropathies, fibromyalgia, neoplasia accompanied by a history of active inflammatory pain or disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-6t2b47y	Hyaluronic Acid Injection for the management of shoulder Impact Syndrome	Not yet recruiting	Intervention	2023-04-25	<NULL>	<NULL>	6032	Hyaluronic Acid Injection for the management of shoulder Impact Syndrome. Triple blind randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Fundação Faculdade de Medicina de São José do Rio Preto	Fundação Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-6t2b47y	<NULL>	Volunteer of both genders; presenting shoulder impingement syndrome with at least three months of symptoms without improvement with conservative treatment; older than 18 years; who have not had previous infiltrations in the evaluated shoulder; no medical contraindications to local anesthesia	Individuals with complete rotator cuff injuries or injuries greater than 50% of the tendon thickness or with traumatic cuff injuries; those submitted to previous infiltrations in the shoulder; who have a previous disease that may interfere with the result of the outcome assessment; with medical contraindication to anesthesia or any of the proposed treatments; with inability to maintain outpatient clinical follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-9p5yqr9	Effect of additional consumption of juçara pulp on weight, body fat and quality of life in post-treatment Breast Cancer patients	Recruiting	Intervention	2023-04-25	<NULL>	<NULL>	6033	Impact of juçara (Euterpe edulis Mart.) supplementation on lipid profile, body composition and quality of life in post-treatment Breast Cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-27	Faculdade de Nutrição da Universidade Federal de Goiás	Hospital de Câncer Araújo Jorge	https://ensaiosclinicos.gov.br/rg/RBR-9p5yqr9	<NULL>	Patients undergoing oncological follow-up for up to 5 years after the last treatment performed, who were diagnosed with triple-negative breast cancer in Stages I to III; attended at the Mastology and Gynecology outpatient clinic of the hospital; age ≥ 18 years; women; is not receiving a nutritional supplement; be able to sign the TCLE; who is on an exclusive oral diet	Participants using anti-inflammatory drugs; patients diagnosed with Diabetes Melittus type I and II; post-treatment patients with other types of cancer; cognitive and/or walking disability; with a closed diagnosis of metastasis; feeding that is not exclusively oral; absorptive dysfunctions (Crohn&apos;s, ulcerative colitis, short bowel syndrome); autoimmune diseases; liver diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-5z2rr58	Evaluation of the effect of Botulinum Toxin as a treatment for Male Pattern Baldness	Recruitment completed	Intervention	2023-04-20	<NULL>	<NULL>	6027	Evaluation of Botulinum Toxin efficacy as a therapeutic option in Male Androgenetic Alopecia	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-19	Faculdade de Ciências Médicas - Universidade do Estado do Rio de Janeiro	Faculdade de Ciências Médicas - Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5z2rr58	<NULL>	Male patients; androgenetic alopecia diagnosis; involvement of the vertex and frontotemporal recesses; age between 20 and 35 years; less than 5 years of disease evolution; all ethnicities and prototypes; patients who never used a treatment and patients who have not used medication for at least six months.	Individuals outside the age range defined for the research; evolution of disease greater than 5 years; women as this is a study aimed at a male audience. Patients with other inflammatory; patients with infectious or tumor conditions concomitant with androgenetic alopecia that affect the scalp and patients undergoing treatment for androgenetic alopecia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-78wjpqz	Effects of sound stimulation and Exercises on the perceptions of individuals with symptoms of Depression	Recruiting	Intervention	2023-04-20	<NULL>	<NULL>	6028	Effects of stimulation by Binaural audio and Self-selected exercises on interoceptive and perceptual responses of individuals with symptoms of Depression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-78wjpqz	<NULL>	Adults; both sexes; symptoms of depression	Attendance less than 70 %	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-33m2tb8	Effect of using a Nursing Care Protocol on a person with an amputation due to Diabetes Mellitus	Not yet recruiting	Intervention	2023-04-20	<NULL>	<NULL>	6029	Effect of using a Nursing Care Protocol on people with Amputations due to Diabetic Complications: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Estadual da Paraíba - UEPB	Universidade de Pernambuco - UPE	https://ensaiosclinicos.gov.br/rg/RBR-33m2tb8	<NULL>	Be 18 years of age or older; present amputation due to diabetic complications; being treated in the inpatient units of the hospitals participating in the study	Patients admitted to the Intensive Care Unit; presenting a medical diagnosis of neurological deficit that hinders the learning process; have hearing and/or visual impairment; Health professionals	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-7wsgdm8	Minoxidil 5 mg oral versus Minoxidil 5 mg sublingual for treating Male Pattern Baldness	Not yet recruiting	Intervention	2023-04-19	<NULL>	<NULL>	6024	Minoxidil 5 mg oral versus Minoxidil 5 mg sublingual for the treatment of Male Androgenetic Alopecia: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-15	Clinica Sanabria Transplante e Restauração Capilar	Clinica Sanabria Transplante e Restauração Capilar	https://ensaiosclinicos.gov.br/rg/RBR-7wsgdm8	<NULL>	Male patients; age between 18 and 55 years; diagnosed with Androgenetic Alopecia classified on the Norwood Hamilton scale in 3V, 4V or 5V; clarified and agreeing to participate in the research, during consultations carried out at Clínica Sanabria	Patients who underwent previous treatment for hair loss in the last 4 months; hypertensive; heart disease; kidney disease; patients with other causes of hair loss or scalp dermatoses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-10kynbky	Comparison of caloric expenditure in two types of high-intensity exercise in middle-aged individuals	Not yet recruiting	Intervention	2023-04-19	<NULL>	<NULL>	6025	Comparison of post-exercise energy expenditure and Excessive Oxygen Consumption (EPOC) in response to high-intensity interval exercise performed in a single session versus three shorter sessions over the course of a day in middle-aged subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-05	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-10kynbky	<NULL>	Healthy individuals aged 45 to 64 years; physically active.	Individuals diagnosed with cardiometabolic, renal, and pulmonary diseases; Individuals with orthopedic or neurological limitations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-5mch8vb	Comparison of aquatic exercise protocols to improve gait in children with Cerebral Palsy	Recruiting	Intervention	2023-04-18	<NULL>	<NULL>	6016	Comparison of intervention protocols in the liquid environment and its impact on the gait of children with Cerebral Palsy	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Hospital e Centro de Reabilitação da Associação de Assistência à Criança Deficiente	Hospital e Centro de Reabilitação da Associação de Assistência à Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-5mch8vb	<NULL>	Children aged between six years and eight years and eleven months with spastic Cerebral Palsy; classified as two or three in the gross motor function classification system	Lack of collaboration, inability to understand commands in the evaluation; children submitted to orthopedic surgeries in the last twelve months; children submitted to peripheral blocks in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-26m455f	Ovarian Suppression Evaluating Subcutaneous Leuprolide Acetate in Breast Cancer	Recruiting	Intervention	2023-04-18	<NULL>	<NULL>	6017	Phase 3, Single Arm, Open-Label Study Evaluating Ovarian Suppression Following Three-Month Leuprolide Acetate For Injectable Suspension (TOL2506) in Combination with Endocrine Therapy in Premenopausal Subjects with Hormone-Receptor–Positive (HR+), Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2021-07-01	Fundação do ABC - Faculdade de Medicina do ABC	LatinaBA	https://ensaiosclinicos.gov.br/rg/RBR-26m455f	<NULL>	Female: Able to understand the investigational nature of this study and provide written informed consent prior to the participation in the trial; Age 18 to 49, inclusive; Diagnosis of Stage I, II, or III HR+, HER2-negative breast cancer (ER&gt;1% and/or, PR&gt;1%, HER2-negative per ASCO CAP guidelines); Is a candidate for endocrine therapy + ovarian suppression; LH &gt; 4 IU/L within 28 days prior to Day 1; Is premenopausal as defined by:E2 &gt; 30 pg/mL; follicle-stimulating hormone (FSH) &lt; 40 IU/L; regular menses (eg, menstrual cycle length of 21 to 35 days). Note: premenopausal status must be determined before neo/adjuvant chemotherapy in patients for which it is planned or prior to Day 1 in patients who did not have prior chemotherapy. If premenopausal status was not determined prior to chemotherapy, E2 and FSH must meet the above criteria when measured 2 weeks or more after the end of the final cycle of chemotherapy. Male: Able to understand the investigational nature of this study and provide written informed consent prior to participation in the trial; Age 18 or older; Diagnosis of Stage I, II, or III HR+, HER2-negative breast cancer (ER&gt;1% and/or, PR&gt;1%, HER2-negative per ASCO CAP guidelines); Is a candidate for endocrine therapy + GnRH agonist	Female: Body mass index (BMI) &lt; 18.00 kg/m2 or &gt; 35.00 kg/m2. Breastfeeding. Life expectancy &lt; 12 months. Eastern Cooperative Oncology Group (ECOG) performance status ≥3. Unacceptable hepatic function as determined by any of the following: Alanine aminotransferase (ALT) ≥ 2X upper limit of normal (ULN); Aspartate aminotransferase (AST) ≥ 2X ULN; Bilirubin ≥ 2X ULN; Alkaline phosphatase ≥ 2X ULN; Severe hepatic impairment (Child-Pugh Class C). Unacceptable renal function as determined by any of the following: Creatinine ≥ 3X ULN; Creatinine clearance ≤ 30 mL/minute; Creatinine clearance ≤ 60 mL/minute in subjects with bone density 1.5 standard deviations below the young adult normal mean. History of significantly abnormal ECG or screening 12-lead ECG demonstrating any of the following: HR &gt; 100 BPM; QRS &gt; 120 msec; QTc &gt; 450 msec; PR &gt; 220 msec. Prior (within 28 days prior to Day 1) and/or concomitant use of medications known to prolong the QT/QTc interval. Prior use of tamoxifen, other SERMs (eg, raloxifene) or antagonists (eg, fulvestrant), aromatase inhibitor, mammalian target of rapamycin (mTOR) inhibitors, or hormone replacement therapy within 3 months before breast cancer diagnosis. Concomitant use of anticancer mediations other than those specified for use by the protocol. Prior neoadjuvant or adjuvant endocrine therapy since diagnosis of breast cancer. History of treatment for osteopenia/osteoporosis. Prior (within 6 months prior to Day 1) or current use of drugs known to increase bone mineral density (ie, bisphosphonates, denosumab, teriparatide, abaloparatide, romosozumab) or use of supplements known to increase bone mineral density (ie, calcitonin, fluoride, strontium) within 28 days prior to Day 1. Low trauma fracture(s) occurring within 12 months prior to subject’s first visit (defined as a fracture that results from a fall from a standing height or less, excluding fingers, toes, face and skull). Conditions that preclude bone mineral density measurement (lumbar spine/bilateral hip surgery with hardware in place, abdominal clips, umbilical ring [not willing to remove] or weight that exceeds the DEXA machine limitation). Any other medical condition or serious illness, presence of a second malignancy under current treatment or follow-up, or the presence of clinically significant findings on the physical exam, laboratory testing, medical history (including conditions that may be associated with low bone mass), that in the opinion of the Investigator may interfere with trial conduct, subject safety, or interpretation of study results. Already receiving and/or previously received GnRH analogs within 1 year before breast cancer diagnosis. Psychiatric, addictive, or other disorders that would preclude study compliance. Use of medications that may impact subject safety and/or affect the PK of the drug and hormonal assessments including but not limited to: Oral or transdermal hormonal therapy within 30 days prior to subject’s first visit; Estrogen, progesterone, or androgens within 30 days prior to subject’s first visit; Hormonal contraceptives within 30 days prior to subject’s first visit; Medications known to result in clinically important decreases in bone mass taken within 6 months prior to subject’s first visit. Known hypersensitivity, idiosyncratic, or allergic reactions to GnRH, GnRH agonist/analogs or to any of the components of the IP. Sexually active with a male partner and not willing to use non-hormonal contraceptive methods throughout the study. Is of childbearing potential with a positive serum pregnancy test at Screening or urine pregnancy test at Day 1. Exposure to any  investigational agent within 30 days prior to the first dose of TOL2506. Male: BMI &lt; 18.00 kg/m2. Life expectancy &lt; 12 months. ECOG performance status ≥ 3. Unacceptable hepatic function as determined by any of the following: Alanine aminotransferase (ALT) ≥ 2X upper limit of normal (ULN); Aspartate aminotransferase (AST) ≥ 2X ULN; Bilirubin ≥ 2X ULN; Alkaline phosphatase ≥ 2X ULN; Severe Hepatic impairment (Child-Pugh Class C). Unacceptable renal function as determined by any of the following: Creatinine ≥ 3X ULN; Creatinine clearance ≤ 30 mL/minute; Creatinine clearance ≤ 60 mL/minute in subjects with bone density 1.5 standard deviations below the young adult normal mean. History of significantly abnormal ECG or screening 12-lead ECG demonstrating any of the following: HR &gt; 100 BPM; QRS &gt; 120 msec; QTc &gt; 450 msec; PR &gt; 220 msec. Prior (within 28 days prior to Day 1) and/or concomitant use of medications known to prolong the QT/QTc interval. Prior use of tamoxifen, other SERMs (eg, raloxifene) or antagonists (eg, fulvestrant), aromatase inhibitor, mTOR inhibitors, or hormone replacement therapy within 3 months before breast cancer diagnosis. Concomitant use of anticancer mediations other than those specified for use by the protocol. Prior neoadjuvant or adjuvant endocrine therapy since diagnosis of breast cancer. History of treatment for osteopenia/osteoporosis. Prior (within 6 months prior to Day 1) or current use of drugs known to increase bone mineral density (ie, bisphosphonates, denosumab, teriparatide, abaloparatide, romosozumab) or use of supplements known to increase bone mineral density (ie, calcitonin, fluoride, strontium) within 28 days prior to Day 1. Low trauma fracture(s) occurring within 12 months prior to subject’s first visit (defined as a fracture that results from a fall from a standing height or less, excluding fingers, toes, face and skull). Any other medical condition or serious illness, presence of a second malignancy under current treatment or follow-up, or the presence of clinically significant findings on the physical exam, laboratory testing, medical history, that in the opinion of the Investigator may interfere with trial conduct, subject safety, or interpretation of study results. Already receiving and/or previously received GnRH analogs within 1 year before breast cancer diagnosis. Psychiatric, addictive, or other disorders that would preclude study compliance. Use of medications that may impact subject safety and/or affect the PK of the drug and hormonal assessments including but not limited to oral or transdermal hormonal therapy within 30 days prior to subject’s first visit. Known hypersensitivity, idiosyncratic, or allergic reactions to GnRH, GnRH agonist/analogs or to any of the components of TOL2506. Exposure to any investigational agent within 30 days prior to the first dose of TOL2506	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-9j7rs22	Anxiety and satisfaction of surgical patients	Not yet recruiting	Intervention	2023-04-18	<NULL>	<NULL>	6018	Anxiety and satisfaction of surgical patients undergoing educational intervention: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-02	Departamento de Enfermagem da Faculdade de Medicina de Botucatu	Hospital das Clinicas da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-9j7rs22	<NULL>	Adult patients undergoing elective colorectal surgeries in any segment; age equal to or greater than 18 years; both gender	Patients with any kind of difficulty in verbal and written communication or comprehension; patients submitted to surgical reoperation due to complications arising from a previous surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-6hk9vgs	Clinical Simulation Scenario for the acquisition of competence in the management of Postpartum Hemorrhage	Recruitment completed	Intervention	2023-04-18	<NULL>	<NULL>	6019	Effectiveness of a Clinical Simulation Scenario for acquiring competence in the management of Postpartum Hemorrhage: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Maternidade Escola Assis Chateaubriand-MEAC	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-6hk9vgs	<NULL>	Being a nurse working in the care of parturients and/or puerperal women in the different sectors of the emergency institution, obstetric center, surgical center, post-anesthesia recovery room, puerperium, maternal ICU	Nurse who has a compromised physical or mental state of health (self-reported), in such a way as to make the clinical simulation unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-9wkgdxp	Moxibustion for the Treatment of Lymphedema in women who have Breast Cancer Surgery	Recruitment completed	Intervention	2023-04-18	<NULL>	<NULL>	6021	Moxibustion as an Adjuvant Therapy in control of Lymphedema in women mastectomized for breast cancer: a randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Faculdade de Enfermagem Nossa Senhora das Graças da Universidade de Pernambuco	Sociedade Pernambucana de Combate ao Câncer	https://ensaiosclinicos.gov.br/rg/RBR-9wkgdxp	<NULL>	Women aged 30 years or older, diagnosed with breast cancer and who underwent unilateral mastectomy at least six months ago, allowing comparison between the two limbs; Undergoing neoadjuvant and/or adjuvant radiotherapy and chemotherapy, which may increase the risk of developing lymphedema; Proof of lymphedema through perimetry of the affected arm ≥3 cm than that of the contralateral arm.	Diseases related to the vascular system, coagulopathies, skin infections or any condition that contraindicates moxibustion; Limb skin trauma, ulceration or skin disease, as such conditions can hinder venous and lymphatic return; Patients who have breathing problems (allergy to subtle smells), since they can be aggravated by the technique; Women who are receiving other treatments for lymphedema other than those established by the service, in order to guarantee homogeneity in the therapeutic protocol and allow comparisons; Previous contact with any modality of moxibustion, as it will make it impossible for the participant to be blinded; Pregnancy, as there is controversy regarding the safety of moxa in early pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-104827wm	Influence of Color Application on Elementary School Students-3rd to 5th grade	Data analysis completed	Intervention	2023-04-18	<NULL>	<NULL>	6022	Influence of Chromatic Stimuli on Elementary School students-Cycle I	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-04	Harumi Falanga Duque	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-104827wm	<NULL>	Healthy volunteers; normal acuity or corrected visual acuity	Volunteers with moderate chromatic alterations (protanomaly or deuteranomaly), strong (protanopia or deuteranopia) and achromatopsia; carriers of diseases or administering medication that could alter color vision; volunteers with a compromised emotional history; with a recent ocular surgical history; volunteers in which those responsible authorized them, however, they did not feel free to participate.In this sense, in addition to the authorization of those responsible for the volunteers, the children&apos;s choice to participate or not was also considered and respected	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-3q9vgk9	Effects of dietary restriction of ultra-processed foods on the health of individuals with excess weight	Data analysis completed	Intervention	2023-04-18	<NULL>	<NULL>	8012	Effectiveness and metabolic impacts of restricting the consumption of ultra-processed foods on metabolic adaptation and weight regain in individuals with excess weight submitted to caloric restriction	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Univerisidade Federal de Alagoas	Univerisidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-3q9vgk9	<NULL>	Adult individuals (19-60 years old); with the wish to lose weight; with a stable weight for at least 1 month; with obesity defined by two of the following three criteria: body mass index between 25 and 40 kg/m2, waist circumference bigger or equal to 88 cm for women and bigger or equal to  102 cm for men, body fat percentage of 35% for women and 25% for men determined by bioelectrical impedance	Individuals using chronic medications (anti-diabetics, anti-retrovirals, immunosuppressants, anti-depressants) or on hormone replacement; those with a condition that makes it impossible to carry out anthropometry or measure the components of energy expenditure; menopause, pregnant or lactating women; those who have already undergone any surgical intervention for weight loss	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:41
RBR-4hbcn6z	Technique for improving the retention of composite Resin Restorations in non-carious cervical lesions	Not yet recruiting	Intervention	2023-04-17	<NULL>	<NULL>	6011	"Evaluation of a technique for improving the retention of composite Resin Restorations in non-carious 
cervical lesions: a randomized clinical trial, split mouth, double-blinded"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-03	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-4hbcn6z	<NULL>	Non-carious non-retentive cervical lesions; non-carious cervical lesions deeper than 1 mm; non-carious cervical lesions with enamel and dentin involvement; teeth without mobility.	Patients with extremely poor oral hygiene; patients with severe or chronic periodontitis; bruxist patients; patients using orthodontic devices; participants allergic to resin-based materials or any other material used in this study; pregnant women; nursing mothers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-109zf3kn	The effects of Pilates Exercises on gait, balance and risk of falls in lower limb Amputees	Not yet recruiting	Intervention	2023-04-17	<NULL>	<NULL>	6012	Effects of a Pilates Exercise program on spatio-temporal parameters of gait, balance and risk of falls in lower limb Amputees	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-30	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-109zf3kn	<NULL>	Unilateral transtibial lower limb amputees; both genders; ages between 18 and 59 years; adapted to prosthetic use for at least 6 months; able to walk independently, without the need for auxiliary equipment; no comorbidities such as high blood pressure and diabetes; able to walk and practice exercises; without paresis or plegia of lower limbs; free from neurological diseases that could compromise verbal comprehension; no injuries to the stump that would affect the use of the prosthesis; who do not use medications that have a proven effect on balance such as antidepressants, tranquilizers or sedatives; be available to participate in the Pilates training program; not present injuries or illnesses or contraindications that prevent the performance of the evaluations and the practice of physical exercises	Lower limb amputees who are not adapted to the use of a prosthesis; who need auxiliary equipment to walk around, such as canes and crutches; hypertensive and diabetic; paresis or plegia of lower limbs; neurological diseases that compromise verbal comprehension; stump injuries; use of antidepressants, tranquilizers or sedatives; other injuries or illnesses that prevent participation in the Pilates training program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-2mzmpxf	Exercise and Nutrition as alternatives to improve the health of schoolchildren with Obesity	Recruiting	Intervention	2023-04-17	<NULL>	<NULL>	6013	Physical Training and Nutritional Education as strategies to modulate the intestinal microbiota and metabolic, inflammatory, and cardiovascular parameters in schoolchildren with Obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2mzmpxf	<NULL>	Obese children; both genders; aged between 7 and 10 years	Children with other chronic diseases; not accepting to participate in the study; prolonged use of antibiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-7nbvjkh	Effects of Individualized Education on Abdominal Dialysis patients	Not yet recruiting	Intervention	2023-04-17	<NULL>	<NULL>	6014	Impact of an Individualized Education tailored for the learning style on Peritoneal Dialysis patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Pontificia Universidade Católica do Paraná	Baxter Healthcare	https://ensaiosclinicos.gov.br/rg/RBR-7nbvjkh	<NULL>	Age higher than 18 years old; chronic peritoneal dialysis for at least 3 months; peritoneal dialysis should be automated peritoneal dialysis; sign the informed consent	Not willing to participate in the study or don&apos;t sign the informed consent; Illiterate; blindness; be on assited peritoneal dialysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-7466htj	Effect of a Counseling Program on Depression symptoms and physical activity, sedentary behavior, and sleep in adults with depressive symptoms	Recruitment completed	Intervention	2023-04-17	<NULL>	<NULL>	6577	Effectiveness of a Counseling Program on Depression symptoms and 24-hour movement behaviors in adults with depressive symptoms	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7466htj	<NULL>	Be a volunteer; score ≥ 9 points on the Patient Health Questionnaire-9 (PHQ-9); be aged between 20 and 59 years; have an electronic device with a camera and microphone installed, such as a computer, tablet or cell phone; have access to the internet; have availability for days and times of online and face-to-face meetings	Present a need for specialized psychiatric treatment, ignoring cases of depression (eg, psychosis, schizophrenia); present suicidal risk (scoring 2/3 in the PHQ-9 suicidal risk question); present change in antidepressant medication in the month prior to recruitment or during the intervention; having diseases or physical limitations that prevent participation in the study; being pregnant or being in the puerperium	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:48
RBR-3g6dbt8	Comparison of the results of non-surgical treatments of clavicle fractures using a sling or immobilizer in eight	Not yet recruiting	Intervention	2023-04-14	<NULL>	<NULL>	6006	Conservative treatment of mid-shaft clavicle fractures, arm sling versus figure-of-eight immobilization. Randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Fundação Faculdade de Medicina de São José do Rio Preto	Fundação Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-3g6dbt8	<NULL>	Volunteers with acute midshaft clavicle fractures (up to 10 days after the trauma); adults between 18 and 65 years old; no medical contraindications for the proposed treatments; acceptance and understanding of the informed consent form	Patients with proximal or distal clavicle fractures, fracture with deviation or shortening greater than 2 cm between the bone fragments in at least one of the radiographic views (AP or Zanca); pathological fracture; open fracture; associated neurovascular injury diagnosed on physical examination; head trauma (Glasgow &lt;12); fracture and/or dislocations in the ipsilateral upper limb; previous diseases in the affected limb that may influence the results; inability to maintain outpatient clinical follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-55sfpf4	Physiotherapy in premature infants: from intensive care to the home environment	Not yet recruiting	Intervention	2023-04-14	<NULL>	<NULL>	6007	Impact of a structured intervention in preterm infants from the intensive care unit to the home environment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-55sfpf4	<NULL>	50 preterm newborns (≤ 32 weeks) and their parents/main caregivers, admitted to the Neonatal Intensive Care Units will be included	Infants with congenital malformations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-107zc6gt	Efficacy of Occlusal Sealants on permanent molars using two bioactive materials: a two-year follow-up clinical trial	Not yet recruiting	Intervention	2023-04-14	<NULL>	<NULL>	6008	Efficacy of Occlusal Sealants on permanent molars using two categories of bioactive materials: a two-year follow-up double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-107zc6gt	<NULL>	Children of both sexes; age between 6 to 8 years; who will voluntarily present themselves for dental care at the Children&apos;s Dental Clinics of UEPG and at the Center for Integral Attention to Children and Adolescents (CAIC UEPG), as well as at Municipal Schools in the municipality of Ponta Grossa; with the presence of permanent molars with indication for the application of preventive sealants (ICDAS 0, but with risk of developing carious lesions) or therapeutic sealants (with the presence of incipient carious lesions ICDAS 1, 2 and 3); who are accompanied by their parents/guardians and/or with the TCLE and TALE duly signed	Children residing in rural areas and/or places where there is no supply of fluoridated water; do not show favorable behavior; are not in good general health and/or have any physical, mental, visual or hearing impairment; are allergic to any of the materials used in the research (latex); use orthodontic appliance in the period stipulated by the survey; have unfavorable oral conditions (presence of abscess, fistula, residual root, intense caries activity)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-7q48mh6	Physiotherapy in Complications resulting from Cancer Treatment	Recruiting	Intervention	2023-04-14	<NULL>	<NULL>	6009	Physiotherapeutic Approach on complications of Cancer Treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-7q48mh6	<NULL>	Individuals over 18 years who presented dehiscence of surgical wounds, recruited from outpatient clinics and doctors who perform oncological surgeries at the University Hospital of Santa Maria, will be included.	Individuals who are not able to understand the guidelines regarding the research due to auto or allopsychic factors, pregnant women, smokers, diabetics with uncontrolled glycemia, patients with infection  or who present tissue necrosis in the initial evaluation, with skin cancer and who underwent radiotherapy prior to surgery or, still, patient with local recurrence. Deep epidermal wounds that present tunnels, that is, a point of injury that extends perpendicularly from the wound under intact skin will also not be included in the study. In addition, excavation-type injuries, with an area of tissue injury parallel beneath intact skin, or full-thickness wounds that reach muscle or bone will be excluded. Patients who are using any topical or systemic medication to improve wound healing (except oil of vegetable origin, alginate, hydrogel or similar), as well as those using anticoagulants will be excluded, in addition to volunteers who miss two consecutive sessions during the treatment and patients who are undergoing another modality of physiotherapeutic care that may interfere with the dehiscent wound.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-2nfjd5g	Evaluation of the Effectiveness of  Multicomponent Oral Hygiene Regimen in Reducing Gum Bleeding	Recruitment completed	Intervention	2023-04-13	<NULL>	<NULL>	5999	Evaluation of the Efficacy of two Multi-Component Oral Hygiene Schemes in patients undergoing non-surgical periodontal treatment: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-30	Universidade de São Paulo	Colgate-Palmolive	https://ensaiosclinicos.gov.br/rg/RBR-2nfjd5g	<NULL>	men and women, between 18 and 65 years of age; availability to participate in the study; good general health (absence of any condition that, in the opinion of the principal investigator, could pose a risk to the subject during study participation. Examples include heart problems, valve/hip replacement, etc.); availability to provide information relating to your medical history; minimum of 15 permanent natural teeth (excluding third molars and teeth with crowns); diagnosis of moderate gingivitis (an initial gingival index score of at least 1.5); at least 10% of sites with bleeding on probing;	presence of any oral pathology or chronic disease that, in the opinion of the main investigator, may constitute a risk for the subject during participation in the study or may modify the progression and/or response to periodontal treatment; daily use of anticonvulsants, antihistamines, sedatives, tranquilizers, anti-inflammatory medication, or analgesics in the month prior to starting the study or scheduled to start using these medications during the course of the study; participation in another clinical trial; pregnancy or lactation; allergy to oral care products to be tested in the study; prolonged use of antibiotics or mouthwashes during the three months prior to the beginning of the study; need for antibiotic prophylaxis; continued use of medications known to affect gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine); periodontal treatment 12 months before the beginning of the study; more than two periodontal pockets (excluding pseudopockets) with bleeding on probing; smoking, history of alcohol abuse and/or drug use; existing medical condition that prohibits the individual from abstaining from eating or drinking for periods of up to 4 hours.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-5jswzbg	Influence of the Pilates method on well-being, Stress and Painful Points reduction during the covid-19 pandemic period	Recruitment completed	Intervention	2023-04-13	<NULL>	<NULL>	6000	Influence of the Pilates method on quality of life, Stress conditions and the reduction of Painful Areas during the period of the covid-19 pandemic	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-5jswzbg	<NULL>	Age over 18 years; men and women; availability of time to carry out the offered protocols; understanding ability	Refusal to receive the protocol; pregnant women; individuals with amputation of one or more limbs; individuals with neurological alterations; not responding to three contact attempts made by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-9p3w4hb	Bleeding Control after Tooth Removal in a patient using anticoagulant medication	Not yet recruiting	Intervention	2023-04-13	<NULL>	<NULL>	6001	Use of Hemostatics in alveolar socket after Dental Extraction in anticoagulated individuals: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-15	Universidade de Cuiabá	Hospital Geral e Maternidade de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-9p3w4hb	<NULL>	Volunteers using anticoagulant therapy continuously; with Surgical indication for tooth extraction; with international normalized ratio (INR) values reported by prothrombin time of up to 3.5; who agree to participate in the research and sign the term of free and informed consent (TCLE) specific to the research in question	Volunteers with changes in preoperative laboratory tests that contraindicate dental surgery; when, for any reason, they suspend the continuous use of medication prior to surgery; individuals who do not cooperate with the postoperative instructions that interfere with the maintenance of the clot	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-72n9y83	Effect of Transcranial Stimulation associated with Speech Therapy on swallowing in the acute phase of Stroke	Recruitment completed	Intervention	2023-04-13	<NULL>	<NULL>	6002	Effect of Transcranial Direct Current Stimulation associated with Speech Therapy on Swallowing in the acute phase of Stroke	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-20	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-72n9y83	<NULL>	Patients diagnosed with ischemic stroke for a maximum of 72 hours (acute phase) will be included; confirmed by computed tomography or magnetic resonance imaging; after neurological evaluation; of both sexes; over the age of 18 years; with dysphagia	Individuals with great swallowing impairment before stroke were excluded; previous episodes of stroke; previous dysphagia; associated neurological pathologies; any metal in the cranial cavity; lesions in the area of electrode placement (some skin change in the scalp in the area to be stimulated); metal in use of pacemaker; previous skull surgery; eyes or decompression surgery; use of medications that interfere with cortical excitability (opiates; benzodiazepines); score above 8 on the hospital scale of anxiety and depression (HAD); uncontrolled epileptic seizure; in addition to clinical instability (systolic blood pressure; drop in systolic blood pressure; heart rate; altered consciousness; cold and sticky skin);  severe cognitive impairment; global aphasia; previous visual disturbances; ; other associated neurological diseases or possibility of pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-32h55z6	Strengthening wrist and hand muscles	Recruitment completed	Intervention	2023-04-13	<NULL>	<NULL>	6003	Effect of a Strengthening Program on the recruitment and strength of wrist and hand muscles	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-32h55z6	<NULL>	women; age between 18 and 30 years; sedentary or non-practitioners of regular physical exercises for the upper limbs; availability to carry out training twice a week during the training period; absence of injury or trauma to both hands; absence of a history of rheumatological diseases in the hands; absence of intense manual labor activity (requiring hand strength).	trauma or injury to the upper limb during the strengthening period; presence of pain or discomfort with training.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-4bdbbbq	Effect of a Nutritional Intervention	Not yet recruiting	Intervention	2023-04-13	<NULL>	<NULL>	6004	Feeding Practices: the effect of a Nutritional Intervention	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-4bdbbbq	<NULL>	66 women; age between 20 to 59 years; BMI between 25 and 39.99Kg/m2; without prior nutritional monitoring; employees linked to the University of Passo Fundo; who accept and sign the Free and Informed Consent Form	women aged less than 20 years or over 60 years; BMI less than 24.99 kg/m2 or greater than 40 kg/m2; perform nutritional monitoring; participate in other intervention protocols; use weight loss medications; pregnant and lactating women; have a non-communicable chronic disease; use medication to any Chronic Noncommunicable Disease; having had previous bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-3tqv8r3	Effect of devices (Low Power Laser and TENS) on Saliva Increase of Patients with Type II Diabetes Mellitus	Recruitment completed	Intervention	2023-04-13	<NULL>	<NULL>	6005	Effect of Low Power Laser associated or not with the use of TENS in the Salivary Stimulation of patients with Type 2 Diabetes Melittus: randomized controlled clinical study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-15	Universidade de Brasília	Empresa Brasileira de serviços Hospitalares - EBSERH	https://ensaiosclinicos.gov.br/rg/RBR-3tqv8r3	<NULL>	Participate in the Extension UnB Project Periodontal Treatment in Diabetic Patients; having type 2 Diabetes Mellitus;present unstimulated salivary flow value less than or equal to 0.2 ml/min, and stimulated less than or equal to 0.7 ml/min; have controlled periodontal disease; Be between 30 and 65 years old	Presence of severe systemic complications and comorbidities;patients who do not have their glycated hemoglobin levels tested;smokers;transplanted;positive history for epilepsy;patients using electronic devices such as: pacemaker, insulin pump and brain drain;difficulty in motor coordination;presence of systemic conditions that may influence the physiology of the salivary gland, such as: Sjogren&apos;s syndrome, hypothyroidism, history of radiotherapy in the head and neck regions and chemotherapy treatment that preceded 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-7qts75k	Effect of Water Exercise on blood pressure in postmenopausal women with High Blood Pressure	Recruiting	Intervention	2023-04-12	<NULL>	<NULL>	5995	Effect of Aquatic Exercise on acute blood pressure response in Hypertensive postmenopausal women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-21	Faculdade de Educação Física e Fisiotrapia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-7qts75k	<NULL>	Women aged between 45 and 65 years; postmenopausal women (1 year of permanent amenorrhea); hypertensive patients properly medicated, not practicing physical exercises regularly and systematically for at least three months; not having musculoskeletal problems or cardiovascular complications that prevent physical exercise; present a medical certificate proving that you are fit for physical exercise; no history of stroke or acute myocardial infarction; not to smoke; not having a diagnosis of Diabetes Mellitus; not practice physical exercises during the evaluation period; not have a pacemaker.	Having any cardiovascular complications during collections; not attending all tests and sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-8cxnvr2	Effects of ear acupuncture on mental health of university students in the Covid-19 pandemic: clinical study	Recruiting	Intervention	2023-04-12	<NULL>	<NULL>	5997	Effects of Laser and Needle Auricular Acupuncture in treatment of Emotional Disorders in university students in the post-Covid-19 pandemic context: randomized clinical	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-20	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-8cxnvr2	<NULL>	University students; aged 18 years or older; who have moderate or high levels of anxiety, stress and/or depression on the Depression, Anxiety and Stress Scale (DASS21) and/or post-traumatic stress disorder, assessed on the Revised Event Impact ( IES-R)	Perforations in the ear near the applied ear points; history of allergy to metal or microporous tape; history of photosensitivity; ear injury, inflammation, deformity or tattoo; history of skin cancer in the head and neck region; use of chemical peeling (retinoic acid, retinol, vitanol-A, tretinoin, isotretioin) and/or Rocutan (isotretinoin) up to six months prior to the start of treatment; use of hearing aids; people with compromised immune systems (being treated for cancer or using immunosuppressants, for example); diabetes mellitus (type 1 or type 2); epilepsy; use of cardiac pacemaker; pregnant women, nursing mothers or those women who are planning pregnancy during the study period; rejection or fear of receiving the intervention; refusal to carry out the assessments; have carried out some integrative and complementary practice in the last 3 months prior to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-5bvjn3q	Implementation of a secondary Prevention Programme for Musculoskeletal Injuries in military	Recruitment completed	Intervention	2023-04-12	<NULL>	<NULL>	5998	Cost-effectiveness of implementing an early Physical Therapy Assessment and Counseling protocol in the secondary prevention of Musculoskeletal Injuries in military	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-30	Escola Naval	Universidade Cidade de São Paulo (UNICID)	https://ensaiosclinicos.gov.br/rg/RBR-5bvjn3q	<NULL>	Be enrolled in the Naval Academy in any year of training; accept to participate in the study by agreeing to the Free and Informed Consent Term ; be able to understand and write in Portuguese (criterion for foreign students) and have a smartphone-type cellular device with possibility of accessing the Internet and free e-mail, text and voice messaging applications, such as SMS (Short Message Service), WhatsApp, Telegram applications, etc.	Those who do not meet the eligibility criteria described above or who have withdrawn from enrollment will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-9qwj44c	Recovery after Surgery to Remove the Gallbladder by Video, with pain medication that includes anesthesia of the nerves in the abdominal area using ultrasound	Recruiting	Intervention	2023-04-11	<NULL>	<NULL>	5990	Postoperative recovery after Laparoscopic Cholecystectomy under Multimodal Analgesia regimen associated with ultrasound-guided Bilateral Subcostal Transverse Plane (TAP) Block	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2022-12-05	Hospital Universitário Julio Muller	Hospital Universitário Julio Muller	https://ensaiosclinicos.gov.br/rg/RBR-9qwj44c	<NULL>	Elective laparoscopic cholecystectomy; age between 18 and 65 years old; both genders; ASA I to III score according to the American Society of Anesthesiologists (ASA).	Acute cholecystitis; acute pancreatitis; acute preoperative pain; morbid obesity; use of medications for chronic pain management or antiepileptics; pregnant women; breastfeeding women; history of alcohol and illicit drug abuse; patients with hepatic cirrhosis; allergy to study drugs; communication problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-95gbvmq	Comparative study to assess the non-inferiority of single daily dosing Gentamicin and Metronidazole versus single daily dosing Gentamicin and three times a day Metronidazole in pediatric patients with Appendicitis	Recruiting	Intervention	2023-04-11	<NULL>	<NULL>	5991	Non-inferiority clinical trial of single daily dosing Gentamicin and Metronidazole versus single daily dosing Gentamicin and three times a day Metronidazole in pediatric patients with Appendicitis	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-01-02	Instituto de Medicina Integral Professor Fernando Figueira	Hospital da restauração	https://ensaiosclinicos.gov.br/rg/RBR-95gbvmq	<NULL>	Patients under 14 years of age; patients admitted with a diagnosis of acute appendicitis and indication for appendectomy at Hospital da Restauração; exclusive antibiotic therapy with Metronidazole and gentamicin with an interval between the start of the antibiotic and the appendectomy of less than 24 hours; absence of associated infection	Immunocompromised patients; pregnancy; previous history of hypersensitivity, reaction, or allergy to metronidazole or gentamicin; patient with severe clinical picture: septic shock, preexisting severe comorbidity that influences (ASA III) postoperative recovery; after randomization, the patient will be excluded if: patients who present an allergic reaction to the administration of metronidazole or gentamicin; appendectomy without diagnostic confirmation during surgery; inadequate infectious source control in the surgeon&apos;s opinion; patients who strictly and exclusively adhere to one of the groups cannot be guaranteed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-7yyx66t	Hemodynamic values among women who have had their breasts removed, submitted or not to ILIB Therapy on the primitive carotid artery using Hormone Blockers	Recruitment completed	Intervention	2023-04-11	<NULL>	<NULL>	5992	Hemodynamic variables among mastectomized women submitted or not to Transdermal Systemic Photobiomodulatory Therapy on the primitive carotid artery under the use of Hormone Blockers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Escola de Enfermagem de Ribeirão Preto - Universidade de São Paulo	Hospital de Câncer de Ribeirão Preto - Sobeccan	https://ensaiosclinicos.gov.br/rg/RBR-7yyx66t	<NULL>	Women; mastectomized; aged between 30 and 85 years; submitted to hormonal treatment with the use of Tamoxifen and Aromatase Inhibitors	mastectomized women; pregnant women; glaucoma carriers; with implanted electronic devices; with active carcinomas of the head and pescoço; with epilepsy; seizures; under treatment of the thyroid gland; pediatric articular epiphysis; transplanted; photosensitive; recently subjected to treatment with steroids; recently subjected to treatment with botulinum toxin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-7k2hpj4	Use of Mobile App for vaginal area exercises for women who lose urine during the Coronavirus pandemic	Data analysis completed	Intervention	2023-04-11	<NULL>	<NULL>	5993	Use of Mobile App for pelvic floor muscle training in women with Urinary Incontinence during the Coronavirus pandemic	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Estadual de Campinas	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti	https://ensaiosclinicos.gov.br/rg/RBR-7k2hpj4	<NULL>	Women with urinary incontinence; age above 18 years; women who have a cell phone with an Android operating system; know how to read and write	Neurological problems that compromise understanding for the practice of exercises, or suggestive of neurogenic bladder; proven or suspected pregnancy; prior treatment for urinary incontinence; pelvic radiotherapy; up to one year after giving birth; three or more lower urinary tract infections in the last 12 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-4thrg35	Evaluation of the effects of Supplementation with L-Citrulline in patients with stomach and colorectal Cancer undergoing Chemotherapy	Recruitment completed	Intervention	2023-04-10	<NULL>	<NULL>	5988	"Evaluation of the effects of L-Citrulline Supplementation in patients with Gastrointestinal Tumors
undergoing Chemotherapy"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-10	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4thrg35	<NULL>	Patients aged 18 years or older; with a diagnosis of gastrointestinal cancer confirmed by biopsy and histological analysis; first neoplasm; under treatment for a maximum of 12 months; capable of supplementation by oral administration	Patients who had any chronic or acute condition that limited their ability to participate in the study; the inability to swallow; and refusal to sign the informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-49p6g3t	Evaluation of pelvic floor muscle function after clinical surgery or surgery associated with cystopexy to control urinary loss	Not yet recruiting	Intervention	2023-04-10	<NULL>	<NULL>	5989	Evaluation of the functionality of the pelvic floor muscles after Urinary Incontinence Surgeries isolated and associated with Cystopexy: a cohort study and clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-49p6g3t	<NULL>	Age between 18 and 65 years; no historic of surgery for urinary incontinence and correction of anterior prolapse; no historic of hysterectomy;	No psychic disorders; neoplasms; the presence of alterations in the organs that present posterior pelvic; decide not to continue the research; withdraw consent;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-5dym7yh	Monitoring Band for Encephalic Involvement in Liver Diseases	Not yet recruiting	Observational	2023-04-05	<NULL>	<NULL>	5984	Non-invasive method for Monitoring Intracranial Pressure in the evaluation of Hepatic Encephalopathy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-04-20	Faculdade de Medicina de São José do Rio Preto - Famerp - SP	Brain4Care	https://ensaiosclinicos.gov.br/rg/RBR-5dym7yh	<NULL>	Subjects with acute liver disease; subjects with chronic liver disease; subjects with exacerbation of chronic liver disease	Refusal by the subjects or their guardians to participate in the study; subjects with healthy liver	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-32v2gm5	Effect of Probiotic and Sorghum Beverage on Metabolic Responses of Normal Weight and Overweight Individuals	Not yet recruiting	Intervention	2023-04-05	<NULL>	<NULL>	5985	Effect of Probiotic (Lactobacillus rhamnosus) and Symbiotic Beverage with Extruded and Germinated Sorghum ([Sorghum bicolor (L.) moench]) on Metabolic Responses of Adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-15	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-32v2gm5	<NULL>	fasting capillary blood glucose ranging from 70 to 99 mg/dL; regular breakfast intake; Body Mass Index (BMI) between 27 and 34.9 kg/m²; body fat percentage &gt; 30% for females and &gt; 20% for males; increased waist circumference; have a level of light physical activity; level of food restriction/disinhibition ≤ 14	smokers; alcohol consumption greater than 2 doses/day (&gt; 50g of ethanol/day); use of medications that affect blood glucose, energy metabolism or appetite; use of medications, herbs, or diets to reduce appetite and body weight; weight instability (gain or loss of more or less 3 kg in the 3 months prior to the beginning of the study); recent change in physical activity level; aversion, intolerance or allergy to food provided in the study; existence or history of recent digestive, liver, kidney, cardiovascular, thyroid or inflammatory diseases, diagnosis of cancer in the previous year; report of eating disorders; pregnant or lactating; use of laxatives or antibiotics in the three months prior to the beginning of the study; continuous use of anti-inflammatory drugs and/or corticosteroids; use of probiotics, prebiotics or synbiotics (&gt; 2 times a week) in the month prior to the beginning of the study; menstrual irregularity three months prior to the start of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-10xp637m	Training to improve attitudes and knowledge and reduce prejudice and discrimination related to Dementia among health professionals	Recruiting	Intervention	2023-04-05	<NULL>	<NULL>	5986	Intervention to improve attitudes and knowledge and reduce stigma and discrimination related to Dementia among community health workers: a pilot study of controlled and randomized feasibility linked to the stride-Brasil project	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-14	Universidade Federal de São Paulo	London School of Economics and Political Science	https://ensaiosclinicos.gov.br/rg/RBR-10xp637m	<NULL>	Community health workers; working in the primary care units of São José dos Campos city	Working as a community health workers for less than 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-3pmvvnx	Application of an application connected to a game with stimulation of mastication and swallowing muscle activity in elderly people with Parkinson&apos;s disease	Recruitment completed	Intervention	2023-04-04	<NULL>	<NULL>	5983	Efficacy of a gamified android mobile device with Electromyographic Biofeedback for mastication and swallowing function in elderly people with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-14	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3pmvvnx	<NULL>	People with Parkinson&apos;s disease: both sexes; aged over sixty years; who have diagnoses of idiopathic PD according to Ordinance No. 228/2010 of the Brazilian Ministry of Health; are between stages 1 to 3 of the disease; people with teeth or using dental prostheses, guided and cared for by family members. Healthy elderly: individuals of both sexes will be included; age over 60 years; with teeth or using dental prostheses and that they are guided.	People with Parkinson&apos;s disease: diagnosed with other neurological diseases associated with PD; cognitive impairment; edentulous in both dental arches, or in the region of posterior teeth with missing teeth without antagonist and with severe dysphagia. Healthy elderly: those with cognitive impairment and who are edentulous in both dental arches.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-83nxqwz	Standardization of breastfeeding techniques for preterm infants	Not yet recruiting	Intervention	2023-04-04	<NULL>	<NULL>	6015	Intervention for health professionals with Bundle on Translactation in an infant using the Kangaroo Method	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Estadual do Ceará	Maternidade Escola Assis Chateaubriand	https://ensaiosclinicos.gov.br/rg/RBR-83nxqwz	<NULL>	healthy babies; with clinical stability; both genders; on full enteral nutrition and a minimum weight of 1250 grams	Babies with orofacial alteration or congenital malformation; diagnoses of cardiac, gastrointestinal, pulmonary pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-10w787j6	Effect of Transcranial Stimulation and Aerobic Training in patients with Heart Failure on physical capacity and inflammatory profile	Not yet recruiting	Intervention	2023-04-04	<NULL>	<NULL>	6274	Effect of Transcranial Direct Current Stimulation associated with Aerobic Training in patients with Heart Failure on physical capacity and inflammatory profile: controlled, randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-08	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-10w787j6	<NULL>	Patients aged over 18 years; Both sexes; Ejection fraction (EF) below 40%; Functional class II or III according to NYHA (New York Heart Association); Who are on optimized clinical treatment	Orthopedic dysfunctions that prevent physical exercise (such as, for example, osteoarthritis in the lower limb and/or spine); Neurological and/or cranial alterations that prevent the application of tDCS (Transcranial Direct Current Stimulation); Diagnosed seizures; Unstable angina symptoms; Patients using a pacemaker or implantable ventricular defibrillators; Metabolic syndromes linked to thyroid or liver; Body mass index (BMI) less than 18.5 and greater than 34,9; Patients with less than 3 months of cardiac decompensation; Patients undergoing cardiovascular rehabilitation in the last 12 months; Patients with cognitive disorders, assessed by the Mini Mental State Examination (MMSE) with a lower score in their education category; Uncontrolled diabetes, systemic arterial hypertension and dyslipidemia; Diagnosed lung disease, such as exercise-induced asthma and pulmonary fibrosis; Pregnant women; Smokers; Alcoholics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-4mx6m8z	Use of an educational program for the care of elderly people at risk of frailty	Data analysis completed	Intervention	2023-04-03	<NULL>	<NULL>	5980	Educational Program for elderly at risk of Fragility	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-4mx6m8z	<NULL>	Elderly; be between 60 and 74 years old; assisted in the selected Basic Health Units; with preserved cognitive ability according to the Mini-Mental State Examination.	Elderly people with hearing, visual or speech deficits that prevented the application of the instruments; vulnerable elderly people who had sequelae that influenced daily life activities; history of lower extremity and/or spinal fractures in the last six months; closed medical diagnosis of mental disorder; elderly people participating in another educational health intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-7t8qnj8	Assessment of the safety and cost of using the medication Pamidronate when used in a one-day or three-day treatment regimen in patients with the rare disease called Fibrous Dysplasia of Bone	Recruiting	Intervention	2023-04-03	<NULL>	<NULL>	5982	Assessment of the safety and cost of using Pamidronate in a single-dose regimen rather than a fractional dose, in patients with Fibrous Dysplasia of Bone	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Estadual Paulista -  UNESP / Faculdade de Medicina de Botucatu - FMB	Universidade Estadual Paulista -  UNESP / Faculdade de Medicina de Botucatu - FMB	https://ensaiosclinicos.gov.br/rg/RBR-7t8qnj8	<NULL>	Bone fibrous dysplasia; bone pain; expanding bone lesion	Creatinine clearance below 30mg/dL	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-3h2gv8r	Contrast-induced renal disease in renal patients	Terminated	Intervention	2023-03-31	<NULL>	<NULL>	5979	Contrast-Induced Nephropathy: evaluation of preventive measures, based on serum levels of Creatinine and Cystatin C, in patients with Moderate and Severe Chronic Kidney Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Hospital Geral de Goiania dr Alberto Rassi	Daniel César Magalhães Fernandes	https://ensaiosclinicos.gov.br/rg/RBR-3h2gv8r	<NULL>	Hospitalized patients with peripheral arterial occlusive disease requiring contrast-enhanced imaging procedures (diagnostic and/or therapeutic arteriography only). Signed informed consent (ICF) was obtained. Patients of any age. Any gender were eligible. Individuals with normal renal function, defined by an estimated glomerular filtration rate (eGFR)&gt;60mL/min/1.73m², were included in the control group. Patients with impaired renal function consistent with moderate chronic kidney disease (eGFR between 30–59 mL/min/1.73m²) .Severe chronic kidney disease (eGFR &lt; 30 mL/min/1.73m²) were also included	Patients with congestive heart failure. Septic or cardiogenic shock. Patients who used nephrotoxic medications or iodinated contrast in the 48-hour period before the evaluation. Patients with acute kidney injury or chronic kidney disease on dialysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:00
RBR-2xnxbs2	Effects of magnetic stimulation over the head on muscle tone in individuals with Multiple Sclerosis	Recruitment completed	Intervention	2023-03-30	<NULL>	<NULL>	5974	Effects of Transcranial Magnetic Stimulation on spasticity in Sclerosis Multiple	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-12	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-2xnxbs2	<NULL>	Participants over 18 years of age with a confirmed diagnosis of Multiple Sclerosis and with Relapsing-Remitting, Primary Progressive and Secondary Progressive subtypes; participants who present quadriceps spasticity assessed by the Ashworth scale grade 3; participants who show a quadriceps motor evoked potential response.	Application of phenol, botox, or other procedures that interfere with quadriceps muscle tone within six months or less; recent fracture or surgery in lower limbs; contracture or deformity in the ankles; contraindications for the use of trancranial magnetic stimulation as history of seizures or refractory epilepsy, metal brain implants, brain tumors, or skin lesion at the site of application.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-3ctb9ry	Evaluation of the interference of peripherally placed deep venous access in the total volume of body water in newborns	Recruitment completed	Intervention	2023-03-30	<NULL>	<NULL>	5975	Evaluation of the interference caused by the presence of a peripherally inserted central venous catheter in the Measurement of Resistance and Reactance with the use of Bioelectrical Impedance in newborns	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Hospital Universitário Antônio Pedro - Universidade Federal Fluminense	Hospital Universitário Antônio Pedro - Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-3ctb9ry	<NULL>	catheters inserted in the right upper limb	newborns with skin lesions where the electrodes were placed; newborn who inserted the catheter in a place other than the right upper limb	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-5zdnw6t	An online-based Nutritional Intervention study to promote a healthy diet among Amazonian schoolchildren (Cruzeiro do Sul/Acre-Brazil)	Not yet recruiting	Intervention	2023-03-30	<NULL>	<NULL>	5976	Remote Nutritional intervention to promote healthy eating practices among Amazonian schoolchildren: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-20	Faculdade de Saúde Pública da Universidade de São Paulo	Faculdade de Saúde Pública da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5zdnw6t	<NULL>	Being a parent or guardian of a 7- to 8-year-old schoolchild (both genders); who is a participant in the Maternal-Infant Birth Cohort Study in Acre; be literate; and have access to a cell phone with internet access	Não ter acesso semanal à internet; não ter disponibilidade para acompanhar o estudo durante as 24 semanas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-2ft3bxw	Thermal monitoring of the Achilles tendon during static and dynamic exercise associated with the application of light therapy	Data analysis completed	Intervention	2023-03-30	<NULL>	<NULL>	5977	Thermomonitoring of the Achilles tendon during Isometric and Eccentric exercise associated with Photobiomodulation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-15	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2ft3bxw	<NULL>	Subjects of both genders; healthy; aged between 18 and 35 years; physically active according to the International Physical Activity Questionnaire classification; who do not have cardiorespiratory, osteomioarticular or neurological diseases that affect the ability to exercise; do not have tendinopathies, ruptures or history of Calcaneal Tendon surgeries; not be diabetic, hypertensive or have varicose veins or arterial and vascular diseases in the calf region	Volunteers who in the evaluation report pain on palpation of the calcaneal tension; those who were unable to complete the exercise protocol; those who during the intervention period present some systemic disease; not perform any of the pre-established assessments in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-467ksmb	Effects of Inclusion of Cannabidiol in the Usual Treatment of Obsessive Compulsive Disorder	Recruiting	Intervention	2023-03-29	<NULL>	<NULL>	5968	Clinical effects of the addition of cannabidiol to the usual treatment of patients with diagnosis of Obsessive Compulsive Disorder	<NULL>	3, single-arm-study, open	3	<NULL>	<NULL>	<NULL>	2021-01-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-467ksmb	<NULL>	Patients of both sexes; aged between 18 and 65 years; diagnosed with obsessive-compulsive disorder; undergoing outpatient pharmacological treatment with selective serotonin reuptake inhibitors or clomipramine; with current symptoms of obsessions, compulsions or both; with severity assessed by the  scale Y-BOCS (Yale-Brown Obsessive-Compulsive Scale) (score greater than or equal to 20 out of a total of 40 possible points).	Age under 18 and over 65 years; presence of relevant medical condition (cardiovascular diseases, severe arterial hypertension, renal failure, liver disease, hypothyroidism, hyponatremia, hypovitaminosis B12, previous intracranial hypertension, epilepsy, pregnancy, breastfeeding); history of neurological disease (including severe traumatic brain injury and excluding headache); previous use of cannabis in the last month or history of dependence on any other psychoactive substance; previous history of allergy or idiosyncratic reactions to cannabis sativa derivatives; psychotic symptoms; suicidal ideation; personality disorder or diagnosis of substance use disorder according to The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria. Patients with changes in their pharmacological regimen in the last 30 days will not be able to participate in the study. Patients using medications that modulate the glutamatergic system (topiramate, lamotrigine, memantine) and benzodiazepines will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-10jd3t6p	Results of the comparison of Educational Actions on the correct identification of the patient	Recruitment completed	Intervention	2023-03-29	<NULL>	<NULL>	5969	Analysis of Care Practices in intensive care units	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-20	Universidade do Estado do Rio de Janeiro	Faculdade de Enfermagem da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-10jd3t6p	<NULL>	Volunteers; both genders; nurses; nursing technicians	Volunteers from other professional categories; vacations or licenses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-5vzynf3	Homeopathic medicine and covid-19 pandemic: a prospective cohort study in Rio de Janeiro	Data analysis completed	Intervention	2023-03-29	<NULL>	<NULL>	5970	Use of homeopathic therapy during the covid-19 pandemic in health units in Rio de Janeiro	<NULL>	1-2, n/a, open	1-2	<NULL>	<NULL>	<NULL>	2020-05-01	Faculdade de Farmácia da Universidade Federal do Rio de Janeiro	Faculdade de Farmácia da Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-5vzynf3	<NULL>	Women and men aged 18 years or older with or not COVID-19 influenza-like symptoms were included in this study	The exclusion criterion was a severe acute respiratory syndrome that leads to hospitalization by primary care teams	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-108vwpqd	Educational action TIV-disinfect (Intravenous Therapy-disinfect) for the hospitalized children and teenagers care	Recruitment completed	Intervention	2023-03-29	<NULL>	<NULL>	5972	Educational Intervention TIV-disinfect in pediatric units: quase-experimental study	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-03-02	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-108vwpqd	<NULL>	Be a nursing professional; be attending patient units in pediatric services at the time of the study	Not answering the instrument in the pre-test; not answering the instrument in the post-test; not participating in the intervention as a whole; respondent the instrument incompletely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-9778pj4	Mobile app to assist in the treatment of Adolescent Idiopathic Scoliosis	Not yet recruiting	Intervention	2023-03-29	<NULL>	<NULL>	5973	Development and validation of a tool for education and assistance in the conservative treatment of Adolescent Idiopathic Scoliosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9778pj4	<NULL>	Female adolescents; age between 10 and 17 years old; diagnosis of adolescent idiopathic scoliosis for at least three months; in conservative treatment with the use of a brace and specific physiotherapeutic exercises for scoliosis; literate, who are attending school regularly; have a smartphone with internet access	Scoliosis with possible non-idiopathic etiology; diagnosis of neurological, neuromuscular pathologies or congenital malformation; other health problems that make physical activity impossible; cognition and learning problems; inability to understand Portuguese; surgery for scoliosis scheduled for the next six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-10d7dj3w	Evaluation of the dermatological acceptability of a health product using the product at home	Not yet recruiting	Intervention	2023-03-28	<NULL>	<NULL>	5966	Dermatological clinical acceptability study under normal conditions of use with cosmetic appreciability (evaluation of the opinion of volunteers) of a health product under normal conditions of use_Ave04.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-25	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Avenca Indústria Cosmética Eireli -EPP	https://ensaiosclinicos.gov.br/rg/RBR-10d7dj3w	<NULL>	Intact skin in the product application region (intimate region); Age 18 to 65 years; Women; Participants with phototypes I, II, III and IV (according to the Fitzpatrick classification); No history of irritation/allergy to the material used in the study; Having signed the Free and Informed Consent Form (TCLE); Participants who want to participate in the study without financial profit	Participants who have or have had symptoms characteristic of COVID-19 for at least 7 days prior to the survey date; Participants who are part of the COVID-19 risk group (elderly people, people with heart and lung diseases, people with immunodeficiencies, people undergoing transplants or undergoing chemotherapy; people with kidney diseases or on dialysis; diabetics, people with liver diseases and obese people) ; participants who refuse to participate in the study in question; Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevus in large numbers, sunburn); Active dermatoses (local and disseminated) that may interfere with the study results; History of dermatological pathologies in the study region; History of allergic reactions, irritation or intense feelings of discomfort to topical products: cosmetics and medications; Participants with a history of allergy to the material used in the study; Intense sun exposure or tanning session up to 15 days before the initial assessment; Prediction of intense sun exposure or tanning session, during the study period; Provision of bathing in the sea, swimming pool or sauna during the study; Participants who practice water sports; Use of the following topical systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to two weeks before selection; Treatment with acidic vitamin A and/or its derivatives orally or topically up to 01 month before the beginning of the study; Prediction of vaccination during the study or up to 03 weeks before the study, in order not to correlate the possible side effects of the vaccine with the study in question; Any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study; Note: the participants included are instructed not to change their diet, cosmetic and hygiene habits, exercise routine and contraceptive method. Also, not to use products from the same category as the product tested in the experimental region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-9zvptxg	Effects of Marijuana on the quality of life of Cancer patients	Recruiting	Intervention	2023-03-28	<NULL>	<NULL>	5967	Effectiveness of Medicinal Cannabis on the quality of life of Oncological patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-05	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9zvptxg	<NULL>	People over 18 years of age; patients who will start treatment with medical cannabis; who are newly linked to cannabis associations; who have been diagnosed with cancer; and who are undergoing cancer treatment.	Interdicted and/or curated patients; under 18 years of age; using antidepressants or anxiolytics, and people undergoing palliative treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-239d9rq	Elimination of congenital transmission of Chagas disease in Bolivia, Brazil, Colombia and Paraguay	Recruiting	Observational	2023-03-27	<NULL>	<NULL>	5961	Towards the elimination of congenital transmission of Chagas disease in Latin America - CUIDA Chagas (United Communities for Innovation, Development and Care for Chagas Disease) - Implementation Research	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-01-02	Instituto Nacional de Infectologia Evandro Chagas	World Health Organization	https://ensaiosclinicos.gov.br/rg/RBR-239d9rq	<NULL>	Woman of Childbearing Age from 15 to 49 years old for Bolivia, Colombia and Paraguay; 10 to 49 years for Brazil; Pregnant women of any age; Newborns; children and children of women with Chagas disease; Household Contacts of Women of Childbearing Age with Chagas Disease; Community members residing in the research municipalities; Health professionals working in the research municipalities and health managers	<NULL>	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-96wmytm	Evaluation of Cardiac Alterations in Tooth Removal Surgery	Recruitment completed	Intervention	2023-03-27	<NULL>	<NULL>	5962	Evaluation of Clinical Parameters in Cardiac patients receiving Local Anesthetics with Vasoconstrictors in Oral Surgery	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Hospital Universitário Onofre Lopes	Departamento de Odontologia da UFRN	https://ensaiosclinicos.gov.br/rg/RBR-96wmytm	<NULL>	Healthy patients; hypertensive patients; patients in need for tooth removal surgery	Patients that did not agree with research protocol as stablished in the consent form; patients allergic to the medications used in the research; patients with medical conditions that contraindicated a surgical procedure in an ambulatory facility	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-4yt3pvc	Effects of Brain Stimulation on Runners	Recruitment completed	Intervention	2023-03-27	<NULL>	<NULL>	5963	Effects of Transcranial Direct Current Stimulation in Athletes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-07	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-4yt3pvc	<NULL>	Individual volunteers of their own free will, with a minimum of 01 year of training experience in the Running Club, between 18 and 32 years of age, with participation in a 5 km race or training in the last two months with a maximum time of 35 minutes to complete the race, must properly complete and sign the Informed Consent Form authorizing participation in the research and participate in all tests as directed.	Individuals who do not perform all the steps as instructed; present depravity in the upper respiratory tract; injuries that make it impossible to perform maximum effort during the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-797p9v5	Justicia Pectoralis Syrup for Cough in children	Recruiting	Intervention	2023-03-27	<NULL>	<NULL>	5964	Justicia Pectoralis Jacq. (Acanthaceae) Syrup for Acute Cough in children with Upper Respiratory Tract Infections: a double-blind, placebo-controlled randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2022-11-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-797p9v5	<NULL>	Age between 1 month and 12 years; Clinical symptoms of upper viral respiratory infection; Up to 48 hours from symptom onset	Previously having asthma or other chronic respiratory conditions; Previously having any coagulopathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-87qh649	Effect of Long-Term Dietary Nitrate Intake on health parameters in individuals undergoing Physical Activity	Recruiting	Intervention	2023-03-27	<NULL>	<NULL>	7200	Effect of Chronic Ingestion of a Nitrate-Rich Diet on muscle performance, vascular health and microbiota composition in different populations undergoing a Training Program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro Campus Macaé	https://ensaiosclinicos.gov.br/rg/RBR-87qh649	<NULL>	Adults aged between 18-45; both sexes; physically active. Apparently healthy elderly people (over 60 years old); both sexes; eutrophic; physically active. unhealthy elderly (over 60 years old); both sexes; overweight; physically active; with the presence of one or more of the following clinical conditions: high triglycerides; high-density lipoprotein reduced cholesterol; increased waist circumference; high fasting blood sugar	Adults with cardiovascular diseases; inflammatory bowel diseases; lung disease; diabetes mellitus; hypertension; dyslipidemia; smoking; urinary infection; pregnant women; lactating women; using drugs that interfere with amino acid metabolism or nitric oxide production; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; the presence of osteomioarticular lesions in 3 months; use of nutritional ergogenics; use of mouthwash. Apparently healthy elderly people without a diagnosis of cardiovascular disease, inflammatory bowel disease, lung disease, diabetes mellitus, hypertension, dyslipidemia and urinary tract infection; smoking; pregnant women, lactating women; using drugs that interfere with amino acid metabolism or NO production; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; use of nutritional ergogenics; use of mouthwash; the presence of osteomioarticular lesions in 3 months. Unhealthy elderly people with any other pathology not previously described; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; use of nutritional ergogenics; use of mouthwash; the presence of osteomioarticular lesions in 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:12
RBR-6h6ykrc	Healthy eating among workers	Recruitment completed	Intervention	2023-03-26	<NULL>	<NULL>	5960	Healthy eating strategies among workers: randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6h6ykrc	<NULL>	Information technology worker; both genders; aged between 18 and 60; know how to read and write	Pregnancy; lactation; noncommunicable disease without treatment, bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-6h5knrj	Virtual rehabilitation in patients with Parkinson&apos;s disease	Not yet recruiting	Intervention	2023-03-24	<NULL>	<NULL>	5957	Telerrehabilitation in individuals with Parkinson&apos;s disease: Single-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Federal do Rio Grande do Norte	Neurobots Pesquisa e Desenvolvimento LTDA	https://ensaiosclinicos.gov.br/rg/RBR-6h5knrj	<NULL>	Individuals participating in a university extension project (AGruPar - Group therapy assistance for individuals with Parkinson&apos;s disease) will be recruited for the study, considering as eligibility criteria: Having clinical diagnosis of Parkinson&apos;s disease; Be between 20 and 70 years old; Being on regular drug treatment for PD; Being in the Parkinson&apos;s disease stage classified from 1 to 3 on the Modified Hoehn and Yahr Scale (HOEHN, YAHR, 1967), considered with mild to moderate disability (SHENKMAN et. al, 2001); Manage to walk for at least 10 meters without personal assistance	Individuals who are unable to handle the devices (computer or mobile) during remote treatment and/or who do not have a caregiver available for the appropriate purposes will be excluded; For this, before we start the evaluations will be asked if there is experience and familiarity with the management of the devices, or if there is any support for this	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-8vvpztm	Effects of strength training with Vascular Occlusion associated with Electrical Stimulation	Not yet recruiting	Intervention	2023-03-24	<NULL>	<NULL>	5958	Effects of strength training with Blood Flow Restriction associated with Neuromuscular Electrostimulation: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Universidade Estadual Paulista Júlio de Mesquita Filho - Instituto de Biociências	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-8vvpztm	<NULL>	Will be included in the study participants of both sexes; aged between 18 and 45 years; physically active	Body Mass Index (BMI) above 30; alterations in sensibilities and mental disturbances that may alter the results or be harmful to the subject; risk factors for thromboembolism; who have a family history of deep vein thrombosis or pulmonary embolism; who have hypertension (blood pressure at rest &gt; 140/90 mmHg)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-9t36r35	Comparative study between the video laryngoscope manufactured by printer and the traditional model in Tracheal Intubation	Not yet recruiting	Intervention	2023-03-24	<NULL>	<NULL>	5959	Comparative study between the 3D-printed videolaryngoscope by lipecin (ufcspa) and the macintosh model in the management of the airways of patients undergoing Tracheal Intubation: clinical, randomized and blinded trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Irmandade da Santa Casa de Misericordia de Porto Alegre	Irmandade da Santa Casa de Misericordia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9t36r35	<NULL>	Patients of both genders; over 18 years old and under 70 years old; candidates for surgeries under general anesthesia and in need of tracheal intubation; with risk classification by the American Society of Anesthesiology	Urgent/emergency surgeries; upper airway surgeries; head and neck surgeries; orthognathic surgeries; surgeries with planned nasotracheal intubation; previous surgeries on the cervical spine; patients with a body mass index greater than 35; patients with cervical disc injury; with spine fractures; patients using a cervical collar; patients with head and neck injuries that preclude the use of standard intubation techniques; patients with type I diabetes; syndromic patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-9wwp8kp	Effect of Physical Exercise in older adults with Pulmonary Disease from Manizales	Data analysis completed	Intervention	2023-03-22	<NULL>	<NULL>	5955	Effect of Physical Training Intervention on the muscular function of elderly adults with Chronic Obstructive Pulmonary Disease from Manizales	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Universidad Autónoma de Manizales	Alcaldía de Manizales	https://ensaiosclinicos.gov.br/rg/RBR-9wwp8kp	<NULL>	Residents of Manizales, Colombia; aged over 50 years; diagnosis of Chronic obstructive pulmonary disease (COPD) (GOLD I-IV) confirmed by spirometry; evidence of a Forced Expiratory Volume in the first second (FEV1) / Forced Vital Capacity (FVC) ratio less than 70	Diagnosis of known respiratory disorders other than Chronic Obstructive Pulmonary Disease (COPD); history of significant inflammatory disease; malignancy; coronary disease; carrier of osteosynthetic material; partial or total limb amputation; neuromuscular, orthopedic and/or medical disease that impedes or physical exercise; CPOD exacerbation in the four weeks prior to inclusion; recent surgery and participation in pulmonary rehabilitation programs or physical exercises in the last year	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-2bz5dm6	Evaluation of skin Irritation and Allergy potential of a Nasal Product under controlled and maximized conditions (RIPT)	Not yet recruiting	Intervention	2023-03-22	<NULL>	<NULL>	5956	Evaluation of the potential for Primary and Cumulative Irritability and Skin Sensitization of a Nasal Spray (094840-01) under controlled and maximized conditions (RIPT)	<NULL>	1, non-randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2023-04-20	Allergisa Pesquisa Dermato-Cosmetica Ltda	Allergisa Pesquisa Dermato-Cosmetica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2bz5dm6	<NULL>	Agreement to comply with safety guidelines to minimize the risks of contamination with COVID-19; healthy participants; both genders; intact skin in the test region; agreement to adhere to trial procedures, scheduled visits, and requirements; ability to consent to your participation in the study in writing; age 18 to 70 years; phototype (Fitzpatrick) I to IV	Participants who belong to the risk group for COVID-19 (diabetes, with chronic cardiovascular, kidney and respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group); pregnant or lactating women; skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevus in large numbers, sunburn); active dermatoses (local or disseminated) that may interfere with the study results; history of allergic reactions, irritation or intense feelings of discomfort to topical cosmetics, health products or medications; history of atopy (atopic dermatitis, allergic rhinitis, allergic bronchitis, allergic conjunctivitis, etc.); discomfort with changes in temperature (too hot/too cold) and/or when using air conditioning; participants with a history of allergy to the materials used in the study; participants with known allergy to acrylates; history of pathologies aggravated or triggered by ultraviolet radiation; people with immunodeficiencies; intense sun exposure or tanning session up to 15 days before the initial assessment; prediction of intense sun exposure or tanning session during the study period; planning to take a bath in the sea, pool or bathtub during the study; participants who practice water sports; dermographism; body aesthetic and/or dermatological treatment up to 03 weeks before selection; use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs and corticosteroids up to 2 weeks before selection or, considering deposit corticosteroids, the interval should be 1 month before selection; treatment with acidic vitamin A and/or its derivatives orally or topically up to 01 month before the beginning of the study; prediction of vaccination during the study or up to 03 weeks before the study; be participating or have participated in another clinical study that ended less than 07 days before the selection, in case the previous study was acceptable in use; be participating or have participated in another clinical study that ended less than 21 days ago, if the previous study is a compatibility or investigative study of Adverse Reaction; any condition not mentioned above that, in the opinion of the investigator, may compromise the evaluation of the study; history of non-adherence or unwillingness to adhere to the study protocol; professionals directly involved in carrying out this protocol and their family members	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-4w9v5rq	The Effect of Individualized Counseling on the duration of Exclusive Breastfeeding	Recruiting	Intervention	2023-03-20	<NULL>	<NULL>	5952	Effectiveness of Individualized Counseling in the duration of Exclusive Breastfeeding: multicenter, randomized, parallel and open clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal do Triângulo Mineiro	Universidade Estadual de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-4w9v5rq	<NULL>	Primiparous women; who had a single fetus alive; with gestational age of 37 to 42 weeks; weighing more than 2,500 grams; regardless of the type of delivery; who are hemodynamically stable; conscious and oriented; and hospitalized in the room-ing, of the participating centers, at the time of the allocation for the study.	Will not be included in the postpartum women and neonates with contraindication for breastfeeding; neonates with malformations that prevent or hinder breastfeeding and/or with changes in the mechanics of breastfeeding (lingual frenulum); postpartum women whose neonates were immediately separated after clamping the umbilical cord at birth due to maternal-neonatal complications; postpartum women transferred from other institutions or who have already been discharged (readmission); postpartum women who use illicit and etilist drugs;  postpartum women with intellectual and/or sensory disabilities;  will be excluded postpartum women which malformations or abnormalities in the mechanics of breastfeeding are detected at the time of allocation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-2bp5q85	Comparison between two types of skin Flaps for making interdigital web space in the Congenital union of fingers	Recruitment completed	Intervention	2023-03-20	<NULL>	<NULL>	5953	Comparison between dorsal rectangular Flap and hourglass Flap in the creation of commissures in simple Syndactyly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-22	Associação hospitalar de proteção a infância doutor Raul Carneiro	Associação hospitalar de proteção a infância doutor Raul Carneiro	https://ensaiosclinicos.gov.br/rg/RBR-2bp5q85	<NULL>	Children up to 06 years of age; with partial or complete finger union; with or without synostosis between the distal phalanges; authorized signature of the free and informed form	Associated syndromes; complex syndactyly; pseudosyndactyly after trauma; reoperations; first commissure syndactyly	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-4mkfmr8	The benefit of Nicotinamide + Vitamin C + Hyaluronic Acid, compared to Hydroquinone in the treatment of Melasma	Recruiting	Intervention	2023-03-20	<NULL>	<NULL>	5954	Efficacy and safety topical Nicotinamide 10%, associated with VCPMG 5% and Hyaluronic Acid 5%, compared to Hydroquinone 4% tested in Brazilian women with Melasma: a double-blind, randomized and controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista	Faculdade de Medicina de Botucatu, Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4mkfmr8	<NULL>	Women; age between 18 and 60 years; with facial melasma; Fitzpatrick phototypes 2 to 5	Pregnant or lactating women; women using other bleaches; women who refuse to be photographed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-26hqvrn	Evaluation of post-operative healing following lower wisdom tooth removal using suture and suture-less techniques	Recruiting	Intervention	2023-03-17	<NULL>	<NULL>	5951	Evaluation of post-operative healing following lower third molar surgery using suture and suture-less techniques: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-24	Faculdade de odontologia da Universidade do estado do Rio de Janeiro	Faculdade de odontologia da Universidade do estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-26hqvrn	<NULL>	(1) Being Healthy, ASA I, according to American Society of Anesthesiologists (ASA), (2) Age from 18 to 40 years old, (3) Presenting indication for bilateral removal of lower third molars, (4) lower third molars with similar position and difficulty level and completly under the mucosal lining, (5) non smoker patients.	(1) pericoronitis around lower third molar; (2) periodontal disease; (3) absence of lower second molar in any side; (4) allergy to any drugs used in the study; (5) pregnant or lactating patients; (6) If a releasing incision is required in the region of lower second molar in order to perform a surgical flap to expose third molar.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-10k2wxrg	Effects of Breaks Sedentary Behavior with unsupervised Isometric Exercise in Sedentary adults	Recruiting	Intervention	2023-03-16	<NULL>	<NULL>	5949	Effects of Breaks from Sedentary  Behavior with unsupervised  Isometric Exercise on Vascular Function, Blood  Pressure and Cardiac Autonomic Modulation in Sedentary adults: Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-10	Universidade Federal Rural de Pernambuco	Universidade Federal Rural de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10k2wxrg	<NULL>	Do not have a diagnosis of cardiovascular disease and diabetes, do not have high cardiovascular risk, do not participate in the physical exercise program for at least six months, occupational activity that requires more than six sitting times per day, and, do not being a smoker or being on medication.	Show adherence below 85% of the training sessions, adhere to another supervised physical exercise program, and,  change the characteristics of occupational activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-58vjpf6	Use of Latex Membrane associated with a Phototherapy equipment in the resolution of Infected Diabetic Feet	Recruiting	Intervention	2023-03-16	<NULL>	<NULL>	5950	Development of a Latex Membrane associated with a Portable Photodynamic Therapy transducer for use in Diabetic Foot infected wounds	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-10	Universidade Federal do Ceará	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-58vjpf6	<NULL>	Diabetic volunteers; both genders; age between 18 and 60 years; diagnosis of type 1 or type 2 diabetes; have infected plantar ulcers	patients with peripheral vascular disease; previous use of local or systemic antibiotics or corticosteroids up to five days before treatment; lactating and pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-8yvhdzj	Effects of TDCS on late muscular pain after resisted training	Not yet recruiting	Intervention	2023-03-15	<NULL>	<NULL>	5948	Effects of Transcranial Direct Current Stimulation (TDCS) on late muscular pain after resisted training	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Faculdade de Ciências da Saúde do Trairí- Universidade Federal do Rio Grande do Norte (FACISA/ UFRN))	Faculdade de Ciências da Saúde do Trairí- Universidade Federal do Rio Grande do Norte (FACISA/ UFRN))	https://ensaiosclinicos.gov.br/rg/RBR-8yvhdzj	<NULL>	sedentary young adult men, recommended by the american college of sports medicine; absence of neurological or rheumatic disease known as rheumatoid arthritis, gout, lupus, and chronic chikungunya; age between 18 and 30 years; availability and interest in participating in the study and not being on analgesic and antinflammatory medication	history of seizures or epileptic illness; metallic implants in the head or neck; having exercised regularly in the last 3 months; acute inflammation of the upper respiratory tract; dental treatment within the last 4 weeks; use of nicotine, coffee or alcohol on the day of the assessment; physical activities as examples cited; walking to college, going up and down stairs, washing clothes, sweeping, up to 2 hours before the assessment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-4hpxhxh	Preoperative use of Pregabalin: evaluation of the Quality of anesthetic recovery in patients undergoing surgery for the treatment of Breast cancer	Recruiting	Intervention	2023-03-14	<NULL>	<NULL>	5945	Preoperative use of Pregabalin versus Placebo: a randomized, double-blind, controlled trial to assess the Quality of anesthetic recovery in patients undergoing Breast cancer surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-09-21	Faculdade de Medicina de Jundiaí	Hospital Universitário de Jundiaí	https://ensaiosclinicos.gov.br/rg/RBR-4hpxhxh	<NULL>	They will integrate 80 patients aged between 20 and 65 years and physical status ASA I or II, who will undergo elective breast cancer surgeries, performed at the University Hospital of the Faculty of Medicine of Jundiaí (Jundiaí-SP).	Patient refusal; altered level of consciousness or inability to communicate; presence of any contraindication to the use of any agent described in the project; history of seizure disorder; currently using pregabalin or gabapentin; presence of chronic pain or use of opioids; body mass index (BMI) &gt;40 kg/m2; insulin-dependent diabetes mellitus and renal failure (estimated glomerular filtration rate less than 60 ml/min/1.73 m²); violation of the protocol (such as the use of agents not described in the study protocol); refusal to respond to the questionnaire (QoR-15) in the perioperative period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-2nygd6j	Impact of Dignity Therapy in Cancer patients in follow-up with palliative care	Recruiting	Intervention	2023-03-14	<NULL>	<NULL>	5947	Dignity Therapy effect in Cancer patients in follow-up with palliative care	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-02	Hospital de Câncer de Barretos	Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-2nygd6j	<NULL>	Greater than or equal to 18 years; carrier of an incurable disease; in exclusive palliative treatment or in joint follow-up (palliative care and oncology); be aware of the disease, incurability and prognosis; be able to understand and express themselves verbally and in writing through the Portuguese language spoken in Brazil; express spontaneous desire to participate in Dignity Therapy at the time of identification of eligibility criteria	Having psychiatric illnesses such as personality disorders; mood disorders; anxiety disorders and psychoses through the evaluation of records in the medical record or prior knowledge of the patient; impaired cognitive ability to carry out reflections such as in situations of delirium due to organ dysfunction and/or end of life as well as dementia; prognosis less than two (2) weeks; for this last criterion it is possible to consider exceptions mainly if the patient has a very strong desire to undergo Dignity Therapy and for this it is extremely important to rearrange the organization of time; the prognosis only limits the patient&apos;s participation if it makes it impossible to maintain a conscious and guided dialogue	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-39vm2nd	Effectiveness of screening actions based on Clinical Breast Examination in Breast Cancer stage and mortality: randomized study	Not yet recruiting	Intervention	2023-03-12	<NULL>	<NULL>	5944	Effectiveness of screening actions based on systematic Clinical Breast Examination in Breast Cancer stage and mortality: randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal de Goiás	Rede Brasileira de Pesquisa em Câncer de Mama	https://ensaiosclinicos.gov.br/rg/RBR-39vm2nd	<NULL>	Participating in the study will be women aged 40 years or older; living in the city of Itaberaí (urban and rural areas); users of the Unified Health System and registered by the Family Health Strategy; who accept to participate in the project and sign the Term of Free and Informed Consent	Women under 40 years of age; with a current or suspected diagnosis of breast cancer or who refuse to collect data or sign an informed consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-4srptw4	Study of a non-invasive brain health assessment device	Recruiting	Observational	2023-03-10	<NULL>	<NULL>	6862	Validation study of the version 2.0 of a non-invasive device for assessing Intracranial Pressure and Compliance	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2023-06-20	Braincare Desenvolvimento e Inovação Tecnologia SA	Braincare Desenvolvimento e Inovação Tecnologia SA	https://ensaiosclinicos.gov.br/rg/RBR-4srptw4	<NULL>	People aged 18 years and older will be admitted to participate in the study; who read the consent form and agree to participate in the study	Volunteers who at some point wish to withdraw from the study; who experience discomfort or excessive movement during the evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:58
RBR-9wrfxcn	Physiotherapeutic intervention in patients with sequels of COVID-19	Recruiting	Intervention	2023-03-08	<NULL>	<NULL>	5940	Physiotherapeutic Intervention in individuals with Post-COVID-19 Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-20	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-9wrfxcn	<NULL>	Volunteers referred to the University of Passo Fundo Physiotherapy Service; age between 20 and 80 years; both genders; presence of symptoms related to SARS-CoV-2 infection and persistent for 12 weeks after diagnosis of COVID-19	Volunteers who complete less than 80% of the sessions; unable to walk (restricted to bed or wheelchair); gestational period; diagnosis of visual impairment, severe hearing impairment, cognitive decline (screened by the Mini Mental State Examination), pressure injuries, cancer, deep vein thrombosis, pulmonary thromboembolism, acute stroke, chronic obstructive pulmonary disease, cystic fibrosis, asthma, hypertension pulmonary; undergoing out-of-hospital physical rehabilitation in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-5tmbpnz	Teleconsultation in nutrition to improve eating habits	Recruitment completed	Intervention	2023-03-08	<NULL>	<NULL>	5941	Nutrition teleservice in improving eating habits: a methodological approach to nutritional monitoring and the perception of nutritionists	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5tmbpnz	<NULL>	Adult patients aged 18 to 59 years; of both sexes; who have access to the internet; are from the community (students, employees and professors) of the Federal University of Sergipe	Children; adolescents; elderly; pregnant women; postpartum women; patients with diabetes mellitus; those who are undergoing nutritional monitoring with another professional at the current time	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-373nf9j	Exercises during hospitalization of Cancer patients	Recruiting	Intervention	2023-03-08	<NULL>	<NULL>	5942	Therapeutic Exercises during hospitalization in Hematologic Cancer patients: a randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-08	Centro Universitário Faculdade de Medicina do ABC	Centro Universitário Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-373nf9j	<NULL>	Patients hospitalized with a diagnosis of malignant hematological disease; age equal to or greater than 18 years; receiving chemotherapy or not; only after signing the free and informed consent form	Neurodegenerative diseases; heart failure, central nervous system metastases; difficulty in communicating and understanding properly; patients who refuse to participate; presence of fever, emesis and diarrhea; platelet count equal to or below 10,000/L; hemoglobin equal to or below 7 g/dL	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-6wgkzs8	Development of an Application to improve health in the elderly	Recruiting	Intervention	2023-03-08	<NULL>	<NULL>	5943	Development and Validation of a Multidisciplinary Mobile Application to promote health habits in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-20	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-6wgkzs8	<NULL>	People with an age equal to or greater than 60 years who have a cellular device that can support the use of the application and its resources	Having limitations to carry out the assessments included in the project, such as visual and auditory limitations and severe cognitive impairments; The Mini Mental State Examination (MMSE) instrument, developed by Folstein et al (1975), will be used, which allows the assessment of cognitive function and the tracking of dementia conditions. cognitive performance or application design	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-2kx385d	Efficacy of forced heating peri-induction of general anesthesia in preventing low body temperature in patients treated for robotic prostate removal surgery. Double-blind randomized controlled clinical trial	Recruiting	Intervention	2023-03-07	<NULL>	<NULL>	5937	Efficacy of peri-induction forced warming in preventing hypothermia in patients undergoing robot-assisted prostatectomy. Double-blind randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-26	Hospital Brasília	Hospital Brasília	https://ensaiosclinicos.gov.br/rg/RBR-2kx385d	<NULL>	Men; Age between 50 and 80 years; physical status ASA I to III (classification related to the diseases the individual has); patients who will undergo elective robotic prostatectomy (removal of the prostate) under spinal analgesia and total intravenous general anesthesia; minimum surgical duration of 60 minutes	BMI &gt;35 kg/m²; preoperative tympanic body temperature &gt;38ºC or &lt;36ºC; patients referred to the ICU (intensive care unit) in post-anesthesia recovery; surgeries lasting less than 60 minutes; patients who have uncompensated thyroid disease (thyroid disease that is not controlled by medication).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-99ydjm8	Evaluation of the effects of Avocado Oil supplementation in patients with Metabolic Syndrome	Recruitment completed	Intervention	2023-03-07	<NULL>	<NULL>	5938	Evaluation of the effects of Avocado Oil supplementation on inflammatory, oxidative and insulin resistance parameters in a double-blind, randomized intervention in patients with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-99ydjm8	<NULL>	Men and women between the ages of 30 and 65 with the ability to provide the Informed Consent Form; BMI (Body Mass Index) above 30 kg/m²; absence of any evidence of active coronary artery disease; presence of three or more of the following five Metabolic Syndromme criteria (IDF)	Individuals with fasting blood glucose greater than 300 mg/dL; limiting genetic and hormonal disease; smokers; abusive use of alcohol and drugs; pregnancy or lactation; refusal to provide a Free and Informed Consent Form; life expectancy less than 6 months (example: malignant neoplasm metastatic); renal failure with indication for dialysis; congestive heart failure; patients with previous organ transplantation; use of food supplements; exacerbated weight loss in the last 3 months (voluntary or involuntary); participation in another experimental study on the date of recruitment; use of lipid-lowering drugs or any medication for the treatment of diabetes with onset less than 3 months ago; non-steroidal anti-inflammatory drugs, corticosteroids or immunosuppressants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-3vhw2hx	Comparison of an Online and Face-to-face Motor Program for infants with Delayed Motor Development	Recruiting	Intervention	2023-03-07	<NULL>	<NULL>	5946	Online and Face-to-Face Program to Improve Motor Development in infants with Delay in Motor Development due to Neurological Injury: a non-randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-10	Universidade Federal de Santa Catarina	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3vhw2hx	<NULL>	Infants at risk for delayed neuromotor development; aged between three and 18 months of corrected age; infants with a risk factor for delayed neuromotor development; including deficits in neurological function according to standardized scales (the General Movements Assessment and a neurological assessment using some items of the Hammersmith Infant Neurological Examination); brain lesions determined by neuroimaging when possible; and delayed motor development (percentile below 25) assessed by the Alberta Infant Motor Scale (AIMS)	Severe genetic abnormalities; hospitalized infants; presence of blindness or deafness; changes in the skin; clinical diagnosis of respiratory diseases; presence of congenital diseases; such as heart disease, renal or ophthalmological alterations; physiologically unstable infants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-3vcg568	The use of Dapagliflozin in patients with Kidney Disease due to Systemic Lupus Erythematosus	Recruiting	Intervention	2023-03-06	<NULL>	<NULL>	5934	The use of Dapagliflozin in Lupus Nephritis patients with residual proteinuria	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-09-26	Hospital das Clínicas/Empresa Brasileira de Serviços Hospitalares/Universidade Federal de Pernambuco	Hospital das Clínicas/Empresa Brasileira de Serviços Hospitalares/Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-3vcg568	<NULL>	Adults; both genders; patients with class III, IV and/or V inactive Lupus Nephritis with proteinuria &gt;500mg/24h and/or urine abumin/creatinine ratio &gt; 200mg/g and estimated glomerular filtration rate &gt; 20ml/min; use of stable maintenance immunosuppression &gt; 4 weeks	Active lupus nephritis (activity index &gt;2 on biopsy less than 12 months old); induction treatment with Cyclophosphamide, Mycophenolate Mofetil &gt;2g/day or associated Cyclosporine regimen; patients with a history of recurrent urinary tract infection (more than 3 episodes per year); clinical or laboratory suspicion of renal or extra-renal lupus activity requiring increased immunosuppression in the last 6 months; use of prednisone at doses greater than 20mg/day for more than 15 days; patients with type 1 or 2 diabetes with Diabetic Nephropathy on renal biopsy; patients with chronic kidney disease of another etiology	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-4m7cpb5	Assessment of quality of anesthesia between two different combinations of anesthetics in outpatient procedures: a clinical trial	Recruiting	Intervention	2023-03-06	<NULL>	<NULL>	5935	Assessment of the quality of anesthesia in patients submitted to ambulatory surgical procedures under sedation with propofol associated with fentanyl or dexmedetomidine: a clinical trial	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2022-11-24	Empresa Brasileira de Serviços Hospitalares - EBSERH	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4m7cpb5	<NULL>	Adult patients; aged between 18 and 65 years; undergoing elective outpatient surgical procedures with sedation performed by an anesthesiologist; procedures should be localized and restricted to the skin and subcutaneous tissue; with an expected duration of between 15 minutes and 1 hour; with ASA classification I to IV; who agreed to participate in the study	Illiterate patients; with some degree of cognitive or mental dysfunction; neurological disease; with a history of allergy to the study drugs; abuse of alcohol and/or illicit drugs or with alterations in renal and/or hepatic function; patients with chronic pain; use of antipsychotic drugs; alpha or beta blockers and/or opioids or who have severe cardiac pathology such as unstable angina; acute myocardial infarction in the last 6 months; heart rate &lt; 50 bpm and systolic blood pressure of 90mmHg; block third-degree atrioventricular or pacemaker; in case of clinical need to use any other medication outside the study protocol or conversion from sedation to general anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-8pjzmsp	Effect of Electrical Brain Stimulation on Pressure, Volume and Brain Activity in Stroke Patients	Data analysis completed	Intervention	2023-03-06	<NULL>	<NULL>	5936	Effect of Transcranial Direct Current Stimulation on Intracranial Pressure and Brain Electrical Activity in the Acute Phase of Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-18	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-8pjzmsp	<NULL>	Individuals over 18 years of age; diagnosed with first stroke confirmed by computed tomography or magnetic resonance imaging; ischemic or hemorrhagic; with up to 72 hours of admission; individuals with severe impairment of motor skills, speech or affectivity, the family member/caregiver must express consent as the person legally responsible for the participant by signing the Free and Informed Consent Form.	Individuals with more than 72 hours of admission; clinically unstable; individuals with any metal in the cranial cavity; pacemakers or implanted defibrillators; individuals with lesions in the electrode placement area; without conditions or refusal by the participant or family member to provide informed consent by signing the Free and Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-7xqzb9h	Treatment for urine loss with urgent symptoms and overactive bladder with High Frequency Energy Waves	Not yet recruiting	Intervention	2023-03-03	<NULL>	<NULL>	5932	Microablative Fractional Radiofrequency versus SHAM in the treatment of women with Urinary Incontinence: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Faculdade de Ciências Médicas  da Universidade Estadual de Campinas	Faculdade de Ciências Médicas  da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7xqzb9h	<NULL>	Women aged between 45 and 65 years; with symptoms of urinary incontinence with a predominance of symptoms of urgency or overactive bladder such as increased frequency, nocturia, urinary urgency, urge incontinence, enuresis; availability to attend the treatment on the date and places previously scheduled	Pacemaker use; presence of genital prolapse stages III and IV; decompensated heart disease; cognitive deficit / difficulty in understanding; peripheral or central neurological impairment (diabetic neuropathy, nerve damage, alzheimer, parkinson); presence of any type of cancer; presence of cervical dysplasia; presence of active urinary or vaginal infection; Decompensated diabetes; mixed incontinence with a predominance of loss on exertion; Patients using estrogen vaginally in the last 6 months; Patients in current use or in the last 6 months of oral hormone replacement therapy; Patient already submitted to prolapse or sling correction surgery; Patients with neurogenic bladder; Patients who underwent drug treatment for emergency incontinence or overactive bladder less than 6 months; Patients who underwent physiotherapeutic treatment of the pelvic floor muscles or transcutaneous electrical stimulation of the tibial nerve in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-8vc5r8b	Success rate of inflamed and necrotised teeth treated with the product LUM01 compared with similar products	Not yet recruiting	Intervention	2023-03-03	<NULL>	<NULL>	5933	Success rate of teeth with apical Periodontitis treated with LUM01: A randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-05-01	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-8vc5r8b	<NULL>	Diagnosis of necrosis with periapical lesion that will be confirmed by a negative response to pulp sensitivity tests (cold and hot tests), and radiographic evidence of periradicular bone resorption (periapical lesion); Apexes completely closed; Need for endodontic treatment; Anatomical classification in relation to curvature classes I or II (Schneider, 1971); Age between 18 and 90 years.	Patients with indication for endodontic retreatment; Images suggestive of periradicular lesions with diameters greater than 8 mm; Patients who used antibiotic therapy, immunosuppressive drugs and anti-inflammatories in the last three months; Teeth with root fractures, with previous endodontic treatment, with the presence of periodontal pockets, with anatomical complexities such as, for example, very pronounced curvatures, dystrophic calcifications, among others, with crown fracture or very extensive caries that would prevent adequate absolute isolation; Pregnant and lactating patients; Patients with systemic and oral diseases that could influence the natural course or treatment of the disease, eg AIDS, diabetes, etc; Patients with systemic conditions requiring prophylactic antibiotic coverage.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-4vdpqrt	Influence of low-doses Dextroketamine on Brain Monitoring	Recruitment completed	Intervention	2023-03-02	<NULL>	<NULL>	5930	Influence of low-doses Dextroketamine on the rate of Electroencephalogram Suppression	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2022-08-15	Hospital São Carlos	Hospital São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4vdpqrt	<NULL>	Volunteers with physical status P1 (American Society of Anesthesiologists); both genders; age between 20 and 50 years; body mass index between 21 and 26kg.m-2	Recent use of drugs that alter the electroencephalogram	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-72vs7nk	The effect of Human Milk Expression on breastfeeding babies of Diabetic Mothers	Recruiting	Intervention	2023-03-02	<NULL>	<NULL>	5931	Exploring the impact of Expressing Human Milk from Diabetic Women on neonatal glycemic control and the rate of exclusive breastfeeding: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-23	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-72vs7nk	<NULL>	Diabetic postpartum women who expressed a desire to breastfeed; Brazilian; aged more than 18 years and singleton pregnancy	Illiterate women; history of previous breast surgery; breast hypoplasia; presence of inverted nipple; polycystic ovary syndrome; postpartum hemorrhage; prolactinoma; children with congenital malformations and associated pathologies as hemolytic disease and sanguine incompatibility; and those who were referred to the Intensive Care Unit before completing the intervention and due to the need to treat neonatal hypoglycemia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-10hd68v7	Physiotherapeutic program of Exercises with Multiple Components in Climacteric symptoms of women at different stages of menopause: a clinical study	Recruitment completed	Intervention	2023-03-01	<NULL>	<NULL>	5925	Multicomponent Exercise physical therapy program in Climacteric symptoms of women at different menopausal stages: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-07	Instituto de Saúde e Biotecnologia da Universidade Federal do Amazonas	Instituto de Saúde e Biotecnologia da Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-10hd68v7	<NULL>	Women over 40 years of age living in the urban area of ​​the municipality of Coari, in the state of Amazonas; positive climacteric symptoms for hot flushes and insomnia; presence of menstrual irregularity or amenorrhea; with or without the use of hormone therapy; preserved cognitive; no history of pituitary dysfunction, neurological diseases and vestibular disorders.	Women with functional limitations, disabling pain or sequelae of diseases that interfere with the physical evaluation proposed in the study; volunteer who does not know her menstrual history which makes it impossible to determine the reproductive phase; voluntary user of psychotropic drugs such as anxiolytics, antidepressants or sedatives; volunteer who misses two consecutive sessions or more than three sessions over the 16 weeks of intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-4mg56yt	Effects of Dry Needling on lungs&apos; air flow, balance and gait of individuals with Parkinson&apos;s Disease	Suspended	Intervention	2023-03-01	<NULL>	<NULL>	5926	Effects of Dry Needling on ventilatory mechanics, balance and gait of individuals with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-04	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4mg56yt	<NULL>	Parkinson&apos;s Disease sufferers; both sexes; over 50 years of age; stages 1 to 3 on the Hoehn-Yahr Scale; able to ambulate and remain standing; being monitored by a neurologist; taking levodopa	Use of walking aids; freezing; previous lung involvement; smokers; history of thoracic surgery; with a diagnosis of associated dementia syndrome; needle phobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-104z966s	Comparison between two Non-Invasive Ventilation methods in children with Acute Respiratory Failure due to Bronchiolitis	Recruiting	Intervention	2023-03-01	<NULL>	<NULL>	5927	Comparison between High Flow Nasal Cannula (HFNC) and CPAP/BiPAP in patients with Acute Respiratory Failure caused by Bronchiolitis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-09	Hospital Municipal Infantil Menino Jesus	Hospital Municipal Infantil Menino Jesus	https://ensaiosclinicos.gov.br/rg/RBR-104z966s	<NULL>	Children under 2 years old; hospitalized for bronchiolitis who evolved with acute respiratory distress and NIV/HFNC requirement	Patients with gestational age less than 35 weeks; bronchopulmonary dysplasia; cyanogenic congenital heart disease or with other alterations with hemodynamic repercussions; liver disease; neuromuscular disease; tracheostomized patients; patients with imminent indication of tracheal intubation; parents that do not agree to sign the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-8hmqbmf	Clinical Performance of Complete Crowns in Printed Resins obtained by Digital Flow in dentistry	Not yet recruiting	Intervention	2023-03-01	<NULL>	<NULL>	5928	Performance of Full Crowns in Printed Resins obtained by CAD/CAM System. Clinical, controlled, triple blind and randomized study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-06	Faculdade de Odontolologia da Universidade Federal de Uberlândia	Faculdade de Odontolologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8hmqbmf	<NULL>	Adult patients aged 18 years or older; both genders; in need of a single crown in a posterior tooth(s) with major coronary destruction; that the tooth has pulp vitality or satisfactory endodontic treatment; with or without intraradicular retainer; that has a medical history that does not compromise the evolution of the results; that has the habit of brushing the teeth at least once a day; that has normal periodontal condition front to probing parameters; has occlusal stability	Patients younger than 18 years old; with some chronic disease with oral manifestations; who present some oral pathology considered serious; with signs and/or symptoms of parafunction (clenching and/or bruxism); with no oral hygiene; with periodontal disease; with allergies to any material that will be used in the study; smokers; or any other condition that may indirectly interfere with the primary and/or secondary outcomes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-9qg9qhh	Effect of oral Probiotic supplementation in children with Obesity: evaluation of the impact on body weight and variables associated with Obesity	Not yet recruiting	Intervention	2023-03-01	<NULL>	<NULL>	5929	Effect of oral Probiotic supplementation in children with Obesity: avaluation of the impact on nutritional status and variables associated with Obesity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-11	Fundação Universidade Federal de São João Del Rei	Secretaria municipal de saúde de Divinópolis	https://ensaiosclinicos.gov.br/rg/RBR-9qg9qhh	<NULL>	Kids; both genders; age between 7 and 10 years; with a nutritional diagnosis of obesity or severe obesity	Children with liver diseases; nephropathy; heart disease; cancer; inflammatory bowel disease using probiotic supplements; prebiotics; symbiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-6c6f8yv	Brain Modulation in patients with Autoimmune Diseases	Recruiting	Intervention	2023-02-28	<NULL>	<NULL>	5924	Transcranial Direct Current Stimulation in patients with Systemic Autoimmune Diseases	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-24	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6c6f8yv	<NULL>	Female patients with the defined systemic autoimmune disease Systemic Lupus Erythematosus (all meet the 2019 EULAR/ACR classification criteria); in regular outpatient follow-up; having a picture of fatigue or significant pain; presenting the Severity of Fatigue Scale (EGF) greater than or equal to 36 points; relatively stable use of medication in the last month; able to understand and complete the Free and Informed Consent Form (TCLE)	Patients with: neoplasms; cardiac pacemaker users; users of cranial metal clips or prostheses; pregnant women; personal history of seizures or epilepsy; users of centrally-acting drugs or drugs that lower the seizure threshold; skin lesion on the scalp; in moderate, intense or very intense disease activity; using moderate to high doses of glucocorticoids; overlapping with systemic autoimmune rheumatic diseases other than antiphospholipid antibody syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-57m44yh	The effect of finger suction on newborn pain relief during needle puncture of their foot: a randomized clinical trial	Recruiting	Intervention	2023-02-27	<NULL>	<NULL>	5923	Efficacy of Non-Nutritive Suction for relief of newborn pain during Heel Puncture: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-20	Hospital de Clínicas de Porto Alegre	Escola de Enfermagem da Uiversidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-57m44yh	<NULL>	Full-term newborns (gestational age ≥ 37 weeks according to the Capurro Method); who have stable vital signs; who have a medical prescription for glycemic control; who do not have pain, according to the Neonatal Infant Pain Scale, before heel puncture; who complete the 8th or 12th hour of life between 6 am and 10 pm	Newborns with congenital malformation; who undergo observation or need to be admitted to the Neonatology Unit; who have received pharmacological analgesia; whose heel puncture technique was not in accordance with the Standard Operating Procedure for Capillary Glycemia Verification	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-54w3vgs	Evaluation of the proctological, gynecological and dermatological acceptability of a health product using the product at home	Not yet recruiting	Intervention	2023-02-24	<NULL>	<NULL>	5922	Evaluation of the proctological, gynecological and dermatological acceptability of a health product under normal conditions of use_MAKE02.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-20	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Makelife Comercio Atacadista e Varejista LTDA	https://ensaiosclinicos.gov.br/rg/RBR-54w3vgs	<NULL>	Women; age: 18 to 59 years old; phototype: I to IV; intact skin of the region; occasional user of category products	Skin marks in the experimental area that interfere with the evaluation of possible skin reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevus in large numbers, sunburn); pregnant or lactating women; participants with a history of allergy to the material used in the study; history of atopy; use of vaginal cream; participants with a history of allergy to cosmetic products in the tested category; recent gynecological surgeries; discharges; people with immunodeficiencies, kidney, heart or liver transplants; active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); topical use with corticosteroids in the experimental area up to 8 days before the beginning of the study. Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-3jxtfm8	Osteopathic Manual Treatment of patients with Ear Noise originating in the head, mouth and neck	Recruiting	Intervention	2023-02-23	<NULL>	<NULL>	5917	Osteopathic Treatment in patients with Somatosensory Tinnitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-02	Hospital das Clínica da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínica da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3jxtfm8	<NULL>	Patients must present uni or bilateral tinnitus for at least 6 months; both sexes; age group above 18 years; that present modulation, that is, perceive alteration in the psychoacoustic characteristics of tinnitus (intensity, frequency and/or location) to active and/or resisted maneuvers in one or more regions: cervical spine, upper limbs, temporal mandibular joint (TMJ) and eyes; as well as modulation of tinnitus by activating muscle trigger points.Other influencing factors are: recurrent headaches, neck or shoulder girdle pain; temporal coincidence in the onset or increase of tinnitus with musculoskeletal pain; handling teeth and head and neck trauma; tinnitus increase due to inadequate postures and/or bruxism for long periods; dysfunction and/or changes in the cervical spine associated with the symptom; patients with and without hearing loss will be included	Patients who underwent physiotherapeutic treatment and/or manual therapies to treat pain and tinnitus up to 3 months before the initial assessment; severe depression in use of medication; clinical diagnosis of fibromyalgia; neurological diseases; and contraindications for physiotherapeutic treatment such as fractures, tumors and rheumatological diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-292qvqs	Bladder catheter duration after Urethral Stricture correction surgery: a randomized trial	Recruiting	Intervention	2023-02-23	<NULL>	<NULL>	5918	Duration of urethral catheterization after Urethroplasty: a randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-292qvqs	<NULL>	Male; 18 years of age or older; diagnosis of urethral stenosis with indication of anterior urethroplasty	Posterior urethral stenosis; bladder neck sclerosis; vesicourethral anastomosis stricture; neurogenic etiology for urinary symptoms or requiring intermittent bladder catheterization; previous anterior urethroplasty; staged urethroplasty; urethral fistulas	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-3ncv48k	Comparative Evaluation of two dermocosmetic products with a Skin Tone Standardization Function	Recruitment completed	Intervention	2023-02-23	<NULL>	<NULL>	5919	Comparative effectiveness evaluation of two seruns through clinical effectiveness assessments, instrumental measurements, image analysis and self-assessment by research participants under normal use conditions (E000311A-01/03)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-12	Allergisa Research Institute	BDF Nivea Ltda	https://ensaiosclinicos.gov.br/rg/RBR-3ncv48k	<NULL>	Healthy study subjects; intact skin on test site; agreement to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; ability of giving consent for participation in the study; aged from 18 to 65 years old; female study subjects; subjects presenting phototype (Fitzpatrick) I to II, III, IV and V to VI; with homogeneous distribution between them 50% of subjects presenting melasma of any intensity on both half faces; according to the Institute scale; solar lentigo confirmed by a dermatologist	Intense sun exposure or tanning session within one month before the initial assessment or intention of being intensely exposed to sunlight or tanning sessions during the study period;  presenting intense tanning signs, according to assessment of study physician; aesthetic and/or dermatological treatment performed on the face within 02 months before initial visit; beginning or change of hormone replacement treatment or medication contraception method within the last 03 months; pregnancy or breastfeeding; skin pathology on the product application site; type 1 Diabetes Mellitus: insulin-dependent diabetes, presence of complications resulting from diabetes (retinopathy, nephropathy, neuropathy); presence of dermatosis related to diabetes (lipoidic necrobiosis, plantar ulcer, ring granuloma, opportunistic infections); antecedents of episodes of hypoglycemia, diabetic ketoacidosis and/or hyperosmolar coma; immunological Insufficiency; current use of the following topical or systemic medications: corticosteroids, immunosuppressive and anti-histaminic drugs; skin diseases as vitiligo, psoriasis, atopic dermatitis; history of reaction to the category of the product tested; other diseases or medications that might directly interfere with the study or put the subject&apos;s health under risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-6sf6njs	Use of Cashew Nut Flour on children with Human Immunodeficiency Virus	Recruitment completed	Intervention	2023-02-23	<NULL>	<NULL>	5920	Effect of Cashew Nut Flour Supplementation on the immunological and nutritional status of children infected with HIV	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Ana Cristina Pereira de Jesus Costa	Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-6sf6njs	<NULL>	Term birth. Receiving Anti-Retroviral Therapy for HIV for at least ninety days. Preserved kidney and liver function	User of psychotropic or antimicrobial or antineoplastic drug. Have started intervention to recover nutritional status. Have an allergy to cashew nut products	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-2qbpczv	Evaluation of a Rapid Salivary Test in Patients with Periodontitis with and without Sistemic Diseases	Data analysis completed	Intervention	2023-02-23	<NULL>	<NULL>	5921	Evaluation of a Rapid Test for Total Saliva Protein in Periodontal Patients with and without Comorbidities	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-20	Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto	Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-2qbpczv	<NULL>	Minimum of 14 natural teeth (at least 10 posterior); periodontitis diagnosis; Systemically healthy patients; patients diagnosed with diabetes or rheumatoid artrhitis	Smoking, pregnancy; total edentulism; recent periodontal treatment; recent use of antibiotics; patients who refused to sign the Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-5spbfz7	Online Group Therapy for weight regain patients after Stomach Reduction Surgery	Data analysis completed	Intervention	2023-02-22	<NULL>	<NULL>	5915	Cognitive Behavioral Intervention in patients who experience weight regain after Bariatric Surgery: a group and online Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-05	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5spbfz7	<NULL>	volunteers of both genders; having performed bariatric surgery more than 2 years ago; age between 18 and 65 years; with a 15% increase in total weight from the lowest weight achieved (nadir)	inability to access the internet	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-8n2y6sq	Assessment of proctological, gynecological and dermatological acceptability using the product at home	Not yet recruiting	Intervention	2023-02-22	<NULL>	<NULL>	5916	Evaluation of the proctological , gynecological and dermatological acceptability of a health product under normal conditions of use_MAKE03.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-04-20	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Makelife Comercio Atacadista e Varejista LTDA	https://ensaiosclinicos.gov.br/rg/RBR-8n2y6sq	<NULL>	Gender: female; Age: 18 to 59 years; Phototype: I to IV; Intact skin in the region; Occasional user of products in the category	"Skin marks in the experimental area that interfere with the evaluation of possible chemical reactions (pigmentation disorders, vascular malformations, scars, increased hairiness, freckles and nevus in large numbers, sunburn); Pregnant or lactating women; Participants with a history of allergies to the material used in the study; History of atopy; Use of vaginal cream; Participants with a history of allergies to cosmetic products in the test category; Recent gynecological surgeries; discharges; People with immunodeficiencies; Kidney, heart or liver transplants; Active cell pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticoid in the experimental area up to 8 days before the beginning of the study. Any condition not mentioned above which, in the opinion of the investigator, may compromise the study evaluation
Note: the participants included are instructed not to change their diet, exercise routine and contraceptive method. Also, do not use products from the same category as the product tested in the experimental region."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-523wzcb	Effect of Docosahexaenoic Acid (DHA) use on the incidence of eye disease of preterm babies	Recruitment completed	Intervention	2023-02-22	<NULL>	<NULL>	6220	Effect of Docosahexaenoic Acid (DHA) supplementation on the incidence of Retinopathy of Prematurity	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Secretaria Estadual da Saúde de Santa Catarina	Maternidade Darcy Vargas	https://ensaiosclinicos.gov.br/rg/RBR-523wzcb	<NULL>	Premature babies with mothers older than 18 years of age; up to 33 gestational age;  who were born at Maternidade Darcy Vargas from March 1 2020 to August 31 2022 whose mothers have signed the Free and Informed Consent Form	Premature babies with congenital eye malformation; whose mothers have been supplemented with omega-3 and who have had infectious diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:35
RBR-2ygk8xs	Clinical evaluation of Prostheses on implants installed by different techniques (Guided and Conventional)	Recruitment completed	Intervention	2023-02-18	<NULL>	<NULL>	7125	Randomized clinical evaluation of Protocol/Overdenture-type Prostheses on morse taper implants installed by Guided versus Non-guided Technique	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-03	Faculdade de Odontologia do Campus de Araçatuba - Universidade Estadual Paulista	Dentscare LTDA	https://ensaiosclinicos.gov.br/rg/RBR-2ygk8xs	<NULL>	Health patients; both genders; who presents loss of dental elements indicated for extractions due to root fractures, caries, endodontic lesions or periodontal disease, who remain totally edentulous at the end of the maxillary indications for rehabilitation with prostheses type protocol or overdenture; presence of adequate bone volume for indication of rehabilitation, confirmed by complementary exams; no systemic contraindications for intraoral surgical therapy; good oral hygiene; over 18 years old	Patients using medication that contraindicates the installation or changes the osseointegration of implants; presence of bone grafts in the planning area made previously that make it difficult to install implants; unfavorable bone conditions for implant placement in previous exams, bone availability for implants smaller than 8.5 mm or with predictable fenestrations in any bone wall that cannot be circumvented during surgery; pregnant or breastfeeding women and compulsive smokers more than 2 packs per day	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-6fjfcfg	Effect of Denture use on the ability to swallow in individuals with a history of Head and Neck Cancer	Recruitment completed	Observational	2023-02-16	<NULL>	<NULL>	5908	Effect of bimaxillary complete dentures on swallowing in individuals with a history of head and neck cancer: cross-sectional study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-12	Faculdade de Odontologia de Araçatuba	Faculdade de Odontologia de Araçatuba	https://ensaiosclinicos.gov.br/rg/RBR-6fjfcfg	<NULL>	Edentulous individuals who wear bimaxillary dentures for at least 6 months, undergoing treatment for head and neck cancer in the mouth, oropharynx, hypopharynx or larynx will be included.	Individuals with neurological disorders or cognitive alterations will be excluded; with a history of lung diseases; with oral-sinusal or orofacial communication; patients with poorly fitted bimaxillary total dentures or those who do not use them and; individuals without oral use for food.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-10v5gcdk	Use of Low Level Laser and Acupuncture in the treatment of Mouth and Skin Lesions caused by Radiation in patients with Head and Neck Cancer	Recruitment completed	Intervention	2023-02-16	<NULL>	<NULL>	5909	Use of Low-Level Laser Therapy and Acupuncture in the treatment of Radio-induced Mucositis and Radiodermatitis in patients with Head and Neck Cancer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-01	Univesrsidade Estadual de Montes Claros	Univesrsidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-10v5gcdk	<NULL>	Patients with confirmed histopathological diagnosis of head and neck squamous cell carcinoma; Age over 18 years; Accept to participate in the study.	Individuals who do not have capacity or have limitations that prevent them from responding to the questionnaires.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-2fdfwf5	Retrospective study of cases of people infected by Monkeypox in Rio de Janeiro	Recruiting	Observational	2023-02-16	<NULL>	<NULL>	5910	Retrospective study of cases of human infection by Monkeypox in the Rio de Janeiro city	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-01	Secretaria Municipal de Saúde do Rio de Janeiro	Secretaria Municipal de Saúde do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2fdfwf5	<NULL>	Be assisted in health units in the city of Rio de Janeiro; have clinical and epidemiological data collected in notification and investigation forms for hMPX by the Municipal Epidemiological Surveillance	Absence of demographic information in the notification form; divergence of information between the laboratory diagnosis and the closure of the case;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-2mvznz3	The effect of Laser Treatment on smell changes in post-COVID-19 patients: a randomized clinical trial	Recruiting	Intervention	2023-02-16	<NULL>	<NULL>	5911	Efficacy of adjunctive use of Photobiomodulation Therapy in olfactory disorders in post-COVID-19 patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-05	Pontifícia Universidade Católica do Paraná	Marco Aurelio Fornazieri	https://ensaiosclinicos.gov.br/rg/RBR-2mvznz3	<NULL>	Individuals aged between 18 and 55 years; Laboratory-confirmed SARS-CoV-2 infection (reverse transcription polymerase chain reaction, RT-PCR); Complaint of olfactory disorder (anosmia, hyposmia, parosmia or phantosmia) for up to one year after COVID-19	Patients under 18 years of age and as this is a different patient profile; Patients over 55 years of age to avoid the effects of age on the morphology of the olfactory epithelium; Patients with psychiatric or neurological disorders; Patients with previous chronic rhinological pathologies; Patients with recovery from anosmia before recovery from COVID-19; Pregnant patients; Pre-existing manifestations of olfactory alterations; History of traumatic brain injury;  Patients who did not complete the follow-up period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-3bskhwf	Non-Invasive Brain Stimulation for motor improvement of children with Autism Spectrum Disorder	Recruiting	Intervention	2023-02-16	<NULL>	<NULL>	5913	Transcranial Direct Current Electrostimulation to facilitate neurofunctional rehabilitation in children with Autism Spectrum Disorder: a randomized, placebo-controlled, double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-10	Universidade Evangélica de Goiás	Follow Kids - Clinica de Neuro Reabilitação Infantil	https://ensaiosclinicos.gov.br/rg/RBR-3bskhwf	<NULL>	Diagnosis of autism spectrum disorder; classified as levels I, II and III according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V); age between three and eight years; comprehension of simple verbal commands; no medication changes at least six months before the beginning of the study and during its performance; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the activities proposed in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-9fjqvng	Effect of jabuticaba on vascular health and muscle recovery	Recruiting	Intervention	2023-02-15	<NULL>	<NULL>	7252	Effect of Jabuticaba Consumption on vascular health and muscle recovery in humans	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-15	Universidade Federal do Rio de Janeiro Campus Macaé	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9fjqvng	<NULL>	Healthy individuals; of both sexes; aged between 18 and 45 years; with at least three months of prior experience in resistance training will be invited to participate in this study	Cardiovascular, pulmonary, or metabolic diseases (e.g., asthma, diabetes, hypertension, dyslipidemia); urinary tract infection; smoking; pregnancy or breastfeeding; limb injuries; use of supplements (creatine, caffeine, antioxidant vitamins, minerals); anabolic steroids or anti-inflammatory drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:14
RBR-6zpc65f	Effect of Physical Training on cardiovascular parameters, quality of life and sleep in the elderly	Recruiting	Intervention	2023-02-14	<NULL>	<NULL>	5905	Effect of a Functional Training Program on echocardiographic, hemodynamic, functional parameters, quality of life and sleep in the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-20	Universidade Federal da Paraiba	Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-6zpc65f	<NULL>	Volunteers of both genders; 60 years of age or older; arterial hypertension in stages I and II; body mass index less than 34.9 kg/m2	Smoking volunteers; morbid obesity; respiratory and heart disease; peripheral arterial disease; musculoskeletal diseases that make it impossible to practice physical exercise; participate in another physical training protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-76jbr5y	Study on anatomical and histological changes of the prostate	Recruiting	Observational	2023-02-14	<NULL>	<NULL>	5906	Study on anatomical and histological changes of the prostate in Benign Prostatic Hyperplasia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-01	Unifesp - Universidade Federal de São Paulo	Unifesp - Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-76jbr5y	<NULL>	Men; age between 18 and 90 years; with benign prostatic hyperplasia; refractory to drug treatment; consistent with surgical treatment	patients who refuse to undergo magnetic resonance imaging and those with infectious processes or suspected prostate cancer on examination that causes an anatomical and structural deformity of the gland	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-43vbh6b	Analysis of the effect of behavioral variables on the pattern of metabolic, cardiovascular and inflammation of physical growth among adolescents	Recruiting	Observational	2023-02-14	<NULL>	<NULL>	5907	Analysis of behaviors of children during growth	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-10	Universidade Estadual Paulista Julio de Mesquita Filho	Faculdade de Ciências e Tecnologia - UNESP / Campus de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-43vbh6b	<NULL>	Healthy adolescents; both genders; aged between 11 and 20 years; signature of the free and informed consent form by the parents or legal guardian	Clinical or metabolic disorder that influences the practice of regular physical activity; regular use of medication that affects lipid parameters, blood pressure and bone metabolism; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-2t7pt25	Effects of different Physical Exercise interventions performed at home on physical conditioning, physical activity level and aspects related to the quality of life of the elderly	Data analysis completed	Intervention	2023-02-13	<NULL>	<NULL>	5901	Effects of different Physical Exercise interventions performed remotely on physical fitness, physical activity level and aspects related to the quality of life of the elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-26	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2t7pt25	<NULL>	Participants must be men and women between the ages of 60 and 70; not practicing physical exercises regularly and systematically for at least twelve months; be a resident of the State of Rio Grande do Sul; have internet access and device for video calling	Smokers; uncontrolled cardiovascular disease; no internet access; any musculoskeletal problems that prevent physical exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-10b889rz	Study related to the effect of Cognitive Behavioral Therapy for insomnia on depression and suicide	Recruiting	Intervention	2023-02-13	<NULL>	<NULL>	5902	Clinical trial related to the effectiveness of TCCI on depressive symptoms and suicidal behavior	<NULL>	2, non-randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2022-01-03	Universidade Federal de Pernambuco	Insituto de Medicina Integral de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10b889rz	<NULL>	Minimum age of 18 years and maximum of 60 years; meet Diagnostic and Statistical Manual for Mental Disorders criteria (DSM-V Criteria) for Depressive Disorder and comorbid insomnia; suicidal behavior according to the criteria proposed by the Columbia Suicide Risk Assessment Scale.	Do not meet the criteria for comorbid insomnia and major depression; Cognitive impairment (Mini Mental State Examination); Make changes to psychotropic medications within 4 weeks of the start of the trial and/or changes made throughout treatment; Present other psychiatric comorbidities such as Schizophrenia, Bipolar Affective Disorder and Anxiety Disorders previously evaluated by the Neurocognition outpatient service of Pernambuco Institute of Integral Medicine; Pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-4m5fmyg	Heart rate variation, caloric expenditure and affective response to exercise in virtual reality	Recruitment completed	Intervention	2023-02-13	<NULL>	<NULL>	5903	Validity of heart rate, caloric expenditure and evaluation of the affective response of an exercise session with virtual reality	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-09-21	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-4m5fmyg	<NULL>	adult; over 18 and under 60; Pass the physical readiness questionnaire, which measures the risk of cardiovascular events; related to physical activity practices in the general population; Be able to read and consent to the study protocol.	Have any physical illness or disability that limits the practice of physical activity; Being using any beta-blocker medication or any other that has a modulating/blocking effect on the heart rate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-9dbpb8n	Effect of different Insoles in patients with Plantar Fasciitis	Recruiting	Intervention	2023-02-13	<NULL>	<NULL>	5904	Effect of different Insoles hardness in patients with Plantar Fasciitis: Randomized control trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9dbpb8n	<NULL>	Participants must be between 30 and 65 years old, both sexes. Participants must present pain for at least twelve weeks and grading at least 3 on the numerical pain scale, in the following situations: in the first steps of the morning and on palpation at the insertion of the plantar fascia located in the medial tubercle of the calcaneus. In addition to at least one of the following criteria: pain after a period of inactivity; pain in the plantar fascia after a recent increase in activities beyond the usual; or Positive Windlass Test.	volunteers who have: Fibromyalgia; musculoskeletal and neuromuscular disorder of a systemic nature; have used custom insoles; have undergone physiotherapy sessions; and have presented musculoskeletal injuries in the lower limbs in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-10chzb2d	Surgery for the treatment of chronic burning pain	Recruiting	Intervention	2023-02-12	<NULL>	<NULL>	5899	Substantia nigra pars reticulata as a target for the treatment of the steady element of neuropathic pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-29	Hospital das Clínicas, Faculdade de Medicina, Universidade Federal de Goiás	Medical School, Federal University of Goiás	https://ensaiosclinicos.gov.br/rg/RBR-10chzb2d	<NULL>	Over 18 and under 75; Patients with neuropathic pain; Patients with compromised quality of life; Patients not undergoing surgical treatment for neuropathic pain; Patients refractory to optimized conservative treatment; Patients with non-surgical optimized therapeutic treatments offered by the public health system.	Injury to the midbrain and/or medial thalamus; Major cognitive-behavioral disorder; Inability to attend pre-established follow-up appointments; Other pain disorders associated with neuropathic pain, such as nociceptive pain and psychogenic pain; Uncontrolled systemic arterial hypertension, active infectious process and uncontrolled blood dyscrasia; Other comorbidities that make the procedure a high-risk act; Use of antiaggregants or antiplatelet agents whose temporary withdrawal is unfeasible due to potential risks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-4zvj6m3	Effect of chemical activation on pain after root canal treatment in young teeth	Recruiting	Intervention	2023-02-12	<NULL>	<NULL>	5900	Effect of irrigant attitude on postoperative pain in regenerative endodontics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Kely Firmino Bruno	União Sul-Americana de Educação	https://ensaiosclinicos.gov.br/rg/RBR-4zvj6m3	<NULL>	Female or male patients, aged 7-11 years, with necrotic anterior teeth with incomplete root formation and foraminal opening greater than 1.0 mm.	Patients with teeth with complete root formation, severe periodontal disease, calcified canals, with root resorption or even those with preoperative symptoms.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-9sbdbg7	Feasibility of Whole Body Vibration exercise and its immediate effect on cognitive and physical functions in elderly with Mild Cognitive Impairment	Recruitment completed	Intervention	2023-02-10	<NULL>	<NULL>	5894	Immediate effect of Whole Body Vibration exercise on executive functions, physical functions and neuroendocrine-inflammatory biomarkers of very elderly individuals with Mild Cognitive Impairment: a feasibility study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-05	Universidade Federal dos Vales do Jequitinhonha e Mucuri	CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico	https://ensaiosclinicos.gov.br/rg/RBR-9sbdbg7	<NULL>	Age 80 years or older; present a clinical picture of Mild Cognitive Impairment, according to the Montreal Cognitive Assessment (MoCA); be considered insufficiently active based on the result of the Active Australia Questionnaire (AAQ); not being on immunosuppressive and/or anti-inflammatory medication, and report any medications in use.	Participants will be excluded if they have epilepsy, gallstones, kidney stones, stroke/apoplexy, decompensated heart, metabolic and chronic inflammatory diseases, those who have an implant, bypass, or stent, those who have a hearing disorder and/or severe visual impairment and refusal to sign the informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-10mm62vs	Use of Family Strategies to reduce chidhood Obesity	Recruiting	Intervention	2023-02-10	<NULL>	<NULL>	5895	Multicomponent Family Intervention for Obesity reduction: a Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-05	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-10mm62vs	<NULL>	Families that have at least one child aged 7 to 12 years old with obesity at home; family has at least 1 meal at home on the day.	Pre-existing genetic disorders associated with obesity (congenital leptin deficiency;Down syndrome; Prader-Willi syndrome); endocrine disorders (hypothyroidism, Cushing&apos;s syndrome); children with a disability that prevents carrying out anthropometric measurements; patients undergoing nutritional monitoring; patients using medication for weight loss; families with more than 5 members residing in the same household; families that have at least one member who had allergies or some other restriction to a hyposodium herb salt ingredient.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-2f3pbms	Magnetic Stimulation of the Brain in Premenstrual Tension	Recruitment completed	Intervention	2023-02-10	<NULL>	<NULL>	5896	Efficacy, tolerability and acceptability of Repetitive Transcranial Magnetic Stimulation in Premenstrual Dysphoric Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2f3pbms	<NULL>	"Confirmed diagnosis of premenstrual dysphoric disorder; Age 18 years or older; Regular menstrual cycles, lasting between 21-35 days; Availability to attend the service on the days designated for the intervention.
."	Lifelong diagnosis of depression, bipolar disorder or schizophrenia (confirmed by a psychiatrist); Use of psychotropic drugs (&quot;controlled drugs&quot;), in the last 04 weeks; Risk of committing suicide;  Pregnancy; Absolute contraindication to transcranial magnetic stimulation, such as having cochlear implant (device to treat deafness) or intracranial metal objects (such as clips for cerebral aneurysm and metal plates); history of seizure in the last 12 months or diagnosis of epilepsy; Treatment with transcranial magnetic stimulation, electroconvulsive therapy or transcranial direct current stimulation in the last 12 months; Alcohol or other drug abuse in the last 06 months; Use of any continuous oral contraceptive (&quot;which make the woman do not have menstruation&quot;) or containing the substance drospireone ; subcutaneous hormonal implant (&quot;implanon&quot;); or injectable contraceptives; or intrauterine hormonal device (&quot;Mirena IUD&quot;);	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-3sg9tq2	Use of Methadone to control postoperative pain in Gastric Bypass Surgery	Recruiting	Intervention	2023-02-10	<NULL>	<NULL>	5897	Use of Methadone in postoperative pain control in Bariatric Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	Hospital Universitário Onofre Lopes	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-3sg9tq2	<NULL>	Patients undergoing primary (non-revision) bariatric surgeries by videolparoscopy; Physical status American Society of Anesthesiology (ASA) II/III; Age between 18 and 65 years	Revision surgeries or two-stage surgeries; Laparotomy (open) surgeries; Patients with a history of drug addiction; Patients with a history of chronic opioid use; Patients with a history of fibromyalgia or chronic pain; Patients with QT prolongation; Methadone allergy; Creatinine clearance rate below 60ml/min	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-633rr3r	Benefits of Electrostimulation in Facial Pain	Recruiting	Intervention	2023-02-10	<NULL>	<NULL>	5898	Effects of Transcutaneous Electrical Nerve Stimulation in the treatment of patients with Temporomandibular Disorders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-10	Centro de Ciências da Saúde da Universidade Federal de Santa Catarina	Centro de Ciências da Saúde da Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-633rr3r	<NULL>	diagnosis of muscular or mixed temporomandibular disorders; adults between 18 and 45 years old; body mass index from 18.5 to 29 points.	diagnosis of temporomandibular joint dysfunction; more than three missing teeth or two missing teeth in occlusion pairs; use of muscle relaxants; neurological impairment that prevents comprehension of tasks; has performed; be below the body mass index.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-744myhk	Safety and efficacy of the Inovare® Transcatheter Valve Implantation via femoral	Recruiting	Intervention	2023-02-09	<NULL>	<NULL>	5893	Transfemoral Implant of the Inovare® Transcatheter Valve - Clinical trial for safety and effectiveness erification	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP	https://ensaiosclinicos.gov.br/rg/RBR-744myhk	<NULL>	Patients with significant calcified degenerative native aortic valve stenosis; Multidisciplinary evaluation by the &quot;Heart Team&quot; that concludes that the patient has a high surgical risk for aortic valve replacement, or presence of porcelain aorta or hostile chest, as well as global clinical condition and comorbidities not fully addressed by the STS risk score, or extreme fragility, or considerable chance of clinical benefit from the transcatheter procedure; Symptoms of heart failure in NYHA functional class equal to or greater than II II; Aortic valve ring with an average diameter between 17,3 and 28,6 mm, documented by imaging method, suitable for positioning and accommodating the Inovare® prosthesis; Coronary ostia height greater than 10 mm or presence of coronary graft that prevents the occurrence of acute myocardial ischemia due to coronary occlusion after the valve is released; Arterial femoral access route considered adequate for the progression of the vascular introducer and prosthesis-balloon system; Signed Free and Informed Consent Form.	"Clinicos: Hemodynamic instability requiring vasoactive drugs or circulatory support; procedure with a clinical need to be carried out in an emergency or time of urgency (not elective); a left-side ventrical fracture that is less than 30%; Diabetic renal insufficiency; severe renal insufficiency with persistently elevated levels of creatinine; clinical or biological signs of infection with widespread effects; Endocardite at intervals no greater than 12 months; a coronary disease requiring elective revascularization during or after the valve procedure; evidence of myocardial infarction within a month or less; cerebral vascular accident or recent transient ischaemic attack (within the last six months); sensitivity to or contraindication to the administration of heparin, ticlopidine, clopidogrel, or radiopaco contrast agent; Anemia, hyperthyroidism, or plaquetopenia; a critical need for anticoagulation due to other causes; active peptic disease, gastrointestinal bleeding within three months or previously diagnosed hemorrhagic days; Expectation of life of less than 12 months due to non-cardiac disease or other disorders.
Anatômicos/morfológicos: Diameter of anel valve greater than or equal to 28,7 mm, or less than or equal to 17,2 mm; ilaco-femoral access route with tortuosity, severe calcification, or reduced luminal diameter that prevents the safe advancement of the introducer arterial and prate system; detection of the presence of stable and significant atheromas in the ascending aorta and/or aortic arch using imaging methods; miocardiopathy with obstructed or severe obstruction of the left ventricle&apos;s exit pathway without possibility of balloon dilatation; Procedure to previously valve the aorta or the mitral (by surgery or by catheter, excluding aorta valvoplastia by balo); moderate or accentuated aortic, mitral, or tricuspid insufficiency; native valve not calcified; Evidence of mass intracardiac bleeding."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-6nxst93	Clinical study to evaluate the efficacy and tolerability of the Meneguetti brush for self-collection of anal specimens to screen for anal cancer and sexually transmitted infections	Recruiting	Intervention	2023-02-09	<NULL>	<NULL>	8350	A crossover, randomized clinical trial to evaluate the efficacy and tolerability of the meneguetti brush in self-collection of anal specimens for screening of intraepithelial lesions and sexually transmitted infections	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2025-06-15	Instituto Nacional de Infectologia Evandro Chagas - Fiocruz	Laboratorio de pesquisa clínica em infecções sexualmente transmissíveis e síndrome da imunodeficiência humana	https://ensaiosclinicos.gov.br/rg/RBR-6nxst93	<NULL>	Participants aged 18 years or older will be included, with no history of anal cancer, pelvic radiotherapy, and/or anal canal stenosis, who report engaging in receptive anal sex and who are under care for the human immunodeficiency virus (HIV) or for HIV prevention at the Evandro Chagas National Institute of Infectious Diseases (INI/Fiocruz).	"Participants who report the following conditions will be excluded: 
History of hereditary or acquired coagulopathies; Platelet count below 50,000/µL; Surgical treatments in the anal canal within the previous 6 months; Use of topical medications in the anal canal (such as trichloroacetic acid or imiquimod) within the previous 3 months; High-resolution anoscopy, sigmoidoscopy, or colonoscopy within the previous 3 months; Anal sample collection, whether for anal cytology or other tests, within the previous 3 months; Use of anticoagulants in the last 5 days; Receptive anal sex, use of lubricants, topical products, creams, ointments, or suppositories, and/or anal washing or enema in the 24 hours prior to the visit; Anal complaints (anal pain, bleeding and/or discharge, or tenesmus) and/or findings during anal inspection (mass, ulceration, fissure, fistulous openings, discharge, prolapse, thrombosed hemorrhoids) on the day of screening. Participants presenting with hemorrhoids, warts, or anal skin tags (plicoma) that, in the proctologist&apos;s assessment, could interfere with sample collection or safety evaluation will also be excluded. These individuals will be referred to the institution&apos;s proctology outpatient clinic for clinical management and will be advised of the possibility of undergoing a new screening after the resolution of these conditions.Participants from Phase 1 are not eligible for participation in Phase 2 of the clinical trial."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-8qp575b	Cognitive function after robot-assisted laparoscopic prostatectomy: a prospective study	Recruitment completed	Observational	2023-02-08	<NULL>	<NULL>	5885	Assessment of cognitive function in potoperative robot-assisted laparoscopic radical prostatectomy:prospective cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-01	Hospital Brasília	Hospital Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8qp575b	<NULL>	Adult patients (between 50 and 70 years old) admitted to the participating center; undergoing robot-assisted laparoscopic radical prostatectomy surgery; american Society of Anesthesiology (ASA) physical status 1 to 3; body mass index between 18 and 35; education greater than or equal to 5 years; having signed an informed consent; no history of brain disease, dementia or other psychiatric disorders that affect cognition;	Surgeries lasting less than and equal to 1 hour; patient referred to the Intensive Care Unit; severe hearing or visual impairment;legally protected adults (under judicial protection, guardianship or supervision), persons deprived of their liberty;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-4d9d42n	Comparative study between the effect of pharmacological and non-pharmacological measures on preoperative anxiety in preschoolers undergoing  outpatient surgeries	Recruitment completed	Intervention	2023-02-08	<NULL>	<NULL>	5886	Comparative study between the effect of pharmacological and non-pharmacological measures on preoperative anxiety in pediatric patients undergoing elective outpatient surgeries: prospective, randomized, blinded study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-20	Casa de saúde assistência médica infantil de urgência	Casa de saúde assistência médica infantil de urgência	https://ensaiosclinicos.gov.br/rg/RBR-4d9d42n	<NULL>	Patients who will undergo circumcision; aged between 2 and 7 years; with physical status according to the American Society of Anesthesiologists (ASA) I and II	"Patients with Autism Spectrum Disorder (ASD); Attention Deficit Hyperactivity Disorder (ADHD); Patients with a previous history of paradoxical effect of Midazolam or hypersensitivity to any of its components; patient with serious diseases in organs such as kidney, liver, lung, heart, brain and bone marrow; patients who use psychostimulant drugs or antidepressants
   Serious diseases in organs such as kidney, liver, lung, heart, brain and bone marrow.
  Use of psychostimulant or antidepressant drugs"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-9y4nwm7	Diagnosis and treatment of Pneumonia in patients using a mechanical respirator, using the Molecular Biology technique	Recruiting	Intervention	2023-02-08	<NULL>	<NULL>	5887	Diagnosis and treatment of Pneumonia in intubated patients with Molecular Biology Method compared to diagnosis standard: prospective, controlled, and randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-02	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9y4nwm7	<NULL>	Patients under mechanical ventilation; both genders; over 18 years old; pneumonia	High probability of death within 24 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-3vj5dc5	How Much Strength Exercise does it take to Improve Insulin Sensitivity?	Not yet recruiting	Intervention	2023-02-08	<NULL>	<NULL>	5888	Acute Effects of Manipulation of Strength Exercise Volume on Insulin Sensitivity in Obese Adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-15	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-3vj5dc5	<NULL>	Individuals of both sexes with obesity (body mass index – BMI &gt; 30 kg/m²); and with central obesity (waist circumference &gt; 102 cm in men and &gt; 88 cm in women); aged over 40 years; with stable body mass (&lt;3 kg) in the last 3 months; able to perform physical activity	Individuals with signs, symptoms or presence of diabetes or any other metabolic disease, cardiovascular disease, cerebrovascular disease, kidney disease, respiratory disease, and osteoarticular disease; use of medication that affect blood glucose or insulin levels; use of anabolic steriods; use of dietary supplements that enchace physical performance (beta-alanine, sodium bicarbonate, caffeine, creatine); pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-9dhx6kj	Evaluation of the distribution of a Balance Training on the risk of falls and posture control in Elderly Fallers	Recruiting	Intervention	2023-02-08	<NULL>	<NULL>	5891	Effects of the distribution of Perturbation-based Balance Training on the control of postural stability and risk of falling in Elderly Fallers	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-10	Escola de Educação Física e Esporte da Universidade de São Paulo (EEFERP-USP)	Escola de Educação Física e Esporte da Universidade de São Paulo (EEFERP-USP)	https://ensaiosclinicos.gov.br/rg/RBR-9dhx6kj	<NULL>	To participate in the study, the eligibility criteria are: being over 65 years old; having fallen at least once in the last six months; walking independently and not participating in any fall prevention program.	Exclusion criteria from the study will be: presenting neurological disorder, scoring less than 24 on the Mini Mental State Examination (MMSE, Annex A); severe osteoarticular problems, presenting any ischemic heart disease that limits physical exercise; chronic obstructive pulmonary disease (COPD) and/or uncontrolled blood pressure. For ethical purposes, all study participants will be invited to carry out the group protocol contrary to the end of the experiment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-8c3chr7	Use of Popsicle with Mint in decreasing thirst after Prostatectomy surgery: randomized clinical trial	Recruitment completed	Intervention	2023-02-08	<NULL>	<NULL>	6162	Use of Menthol Popsicle in the management of postoperative thirst in patients undergoing Radical Prostatectomy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-15	Liga Norteriograndense Contra o Câncer	Liga Norteriograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-8c3chr7	<NULL>	Be between 18 and 60 years old; Being female;Fasting for at least 6 hours; Approval in the evaluation of the Security Protocol in the Management of Headquarters	Water restriction during ingestion or swallowing; Having an allergy or hypersensitivity to menthol or green dye	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-4xh6232	The effect of therapeutic ultrasound treatment combined with intense physical exercise on reducing abdominal fat and body composition in overweight and obese young adults	Recruiting	Intervention	2023-02-08	<NULL>	<NULL>	8066	Effects of Therapeutic Ultrasound and Aussie current associated with High Intensity Interval Training on body composition in overweight and obese young adults: randomized placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2024-02-10	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-4xh6232	<NULL>	Both sexes; age between 18 and 40 years; classified as overweight or grade I or grade II obesity according to fat mass index measured by dual-energy x-ray absorptiometry; healthy adults without any chronic or acute disease and who started any physical activity in the previous 3 months.	Electrocardiographic alterations including ischemia, overloads, conduction disorders, and severe arrhythmias such as ventricular tachycardia; fat mass index below or equal to normal or above grade III obesity; initiation of any physical activity in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:19
RBR-5j74ddg	Non-invasive evaluation of the pediatric intracranial pressure	Recruiting	Observational	2023-02-07	<NULL>	<NULL>	5878	Evaluation of the intracranial pressure curve in pediatric through the non-invasive method	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-04-19	Hospital Pequeno Príncipe	Braincare Desenvolvimento e Inovação Tecnológica S.A.	https://ensaiosclinicos.gov.br/rg/RBR-5j74ddg	<NULL>	AActive group: Patients aged 2 to 17 years 11 months and 29 days; Patients of both sexes; Patients who show signs and symptoms of probable intracranial hypertension such as; headache; visual changes; nausea;vomiting;  irritability; cognitive changes; changes in level of consciousness; apilledema; Patients in which a parent or legal guardian consents and signs the Informed Consent Form (ICF); Patient who consents and signs the Informed Consent Form (TALE). Control Group: Patients aged 2 to 17 years 11 months and 29 days; Patients of both sexes;Patients who present neurological examination, performed by a qualified doctor; within the normal range; Healthy patients, selected according to a previous questionnaire with no signs and symptoms related to ICH (headache, visual changes; nausea; vomiting; irritability; cognitive changes; changes in level of consciousness; papilledema); Patients in which a parent or legal guardian consents and signs the Informed Consent Form (ICF)	Active group: Recent surgery with manipulation of the scalp; this reduces the possibility of post-operative control. Sedation that interferes with the measurement of intracranial compliance; Patient outside the chosen pediatric age group; Cranial deformities that prevent the placement of the sensor; Extensive scalp lesion; Patients who do not accept monitoring through the Brain4care device; Patient with complementary Brain Death clinic / exams; Patients in whom the legal guardian or a parent does not consent to participation; Control Group: Patients outside the age range defined for the study; Patients who present signs and symptoms of ICH; Patients with signs and symptoms of neurological degradation; Rheumatological patients; Neurological patients; Cardiac patients; Nephrological patients; Respiratory patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-5p6nv8b	The effect of grape seed flour Supplementation on decreasing weight loss and muscle mass before and after surgery in patients with colorectal cancer Cachexia.	Not yet recruiting	Intervention	2023-02-07	<NULL>	<NULL>	5879	Grape seed flour Supplementation as a strategy to reverse muscle mass loss in perioperative colorectal cancer Cachexia patients: a translational study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-16	Universidade Federal de São Paulo	Hospital Guilherme Álvaro	https://ensaiosclinicos.gov.br/rg/RBR-5p6nv8b	<NULL>	Histopathological diagnosis of colorectal carcinoma; Indication of curative surgery for resection of malignant primary colorectal tumor; Tumor classification according to the Union for Internacional Cancer Control (UICC) criteria; Pre-cachexia or cachexia diagnosis (2011 Consensus); Age between 40 and 90 years; Signed Informed Consent;	Confirmed distant metastasis; Radio/Chemotherapy treatment in the last 3 months; Body Mass Index (BMI) greater than 40 kg/m²; History of liver function impairment (Child-Pugh-Turcotte score B and C); History of chronic kidney disease (defined according KDIGO 2012); HIV positive with AIDS-related complications; Hypersensitivity to trial supplement; Continuous supplementation of polyphenols or pre/probiotics in the last 3 months; Inflammatory bowel diseases (IBD) or chronic inflammatory processes unrelated to cachexia, such as autoimmune disorders; Pregnancy or breastfeeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-2hgwvgy	Comparative study between CO2 laser and Fractional Radiofrequency in the treatment of Vaginal Atrophy	Recruitment completed	Intervention	2023-02-07	<NULL>	<NULL>	5881	Microablative CO2 laser versus Fractionated Microablative Radiofrequency in the treatment of Genitourinary Menopause Syndrome: a controlled, randomized, double-blind, non-inferiority clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Brasil	Cássia Caroline Garcia Dalbem Teles	https://ensaiosclinicos.gov.br/rg/RBR-2hgwvgy	<NULL>	Physiologically postmenopausal women with amenorrhea longer than one year and plasma follicle-stimulating hormone dosage greater than 40 U/l and estradiol less than 25 pg/mL. Age between 50 and 70 years. Present clinical symptoms of the menopausal genitourinary syndrome. Current cervical cytological exam performed in the last six months negative for neoplasia	Women who have received any form of hormone replacement therapy in the past six months. Women who have used non-hormonal vaginal lubricants or moisturizers in the past month. Presence of active genital infections. Patients with a history of genital herpes who are unwilling to take oral Acyclovir prophylaxis. Women who have chronic inflammatory diseases that make the procedures unfeasible. Carriers of thrombophilia or regular users of anticoagulants or platelet antiaggregants. Patients that present vaginal prolapse of second or third degree according to the Pelvic Organ Prolapse Quantification System. Patients with a history of photosensitivity. Those who have had previous treatment with endovaginal CO2 laser or micro ablative Radiofrequency in any period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-2ds9ky9	Effects of Dance Therapy on the ability to perceive and learn movements in children with Autism Spectrum Disorder and its impact on autonomy in activities of daily living	Recruitment completed	Intervention	2023-02-07	<NULL>	<NULL>	5882	Effects of Dance Therapy on perceptive-motor skills of children with Autism Spectrum Disorder and its impact on autonomy in daily life activities	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Programa de Pós Graduação em Ciências da Reabilitação da Universidade Federal de Alfenas	Programa de Pós Graduação em Ciências da Reabilitação da Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2ds9ky9	<NULL>	Interdisciplinary Diagnosis of Autism Spectrum Disorder; Both genders; age range between 5 to 7 years old; They were under a period of social isolation; Signed the Informed Assent Term (TAE); Parents and/or guardians who consented to voluntary participation and signed the Free and Informed Consent Term (FICT)	Presence of other associated physical, neurological, psychic or psychological impairments; Showing hyperirritability to music; Have severe behavioral disorders; Already perform therapeutic intervention based on music or focusing on activities of daily living	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-6qhpvjz	Effect of Block age on Thoracic Transverse Plan in Cardiac Surgery	Recruitment completed	Intervention	2023-02-07	<NULL>	<NULL>	5883	Evaluation of the Blockage of the Transverse Muscle of the Chest Guided by Ultrasound in Cardiac Surgery: randomized clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-12-01	Hospital Universitário Onofre Lopes	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-6qhpvjz	<NULL>	Patients admitted to the universitario onofre lopes hospital to undergo non-coronary cardiac surgery with median sternotomy	Refusal of the patient;Patients under 18 years of age or older than 70 years;Ejection fraction &lt; 35%;Urgent cardiac surgery;Current or previous myocardial revascularization surgery;Patients with body weight &lt; 50 kg or BMI&gt;40kg/m2 ASA ≥ IV;Severe systemic disease (renal, hepatic, pulmonary or endocrine);Hematological disorders;Hemodynamic instability;Pregnancy;Patient with chronic pain, using analgesics;Psychiatric or cognitive disorders;Allergy to drugs used in research; Contraindication to regional blockades according to the American Society of Regional Anesthesia and Pain guideline	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-6k6gv65	Laserpuncture in Temporomandibular Disorders	Recruiting	Intervention	2023-02-07	<NULL>	<NULL>	5884	Effectiveness of Laserpuncture in Temporomandibular Disorders, a Randomized Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	financiamento Próprio	Universidade Estadual de Campinas Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-6k6gv65	<NULL>	Adult volunteers of both sexes, aged 18 to 60 years, with pain due to temporomandibular disorders (TMD) of mixed origin. TMD will be diagnosed by the DC\TMD Diagnostic Criteria for Temporomandibular Disorders (Schiffman, 2014). The mandibular functional limitation questionnaires (JFLS: Jaw Functional Limitation Scale); evaluation of the volunteer&apos;s emotional alteration with the questionnaire (PHQ-4: Distress (Depression &amp; Anxiety)) and the evaluation of oral behaviors by the OBC questionnaire: Oral Behaviors Checklist, will be completed and then the clinical diagnosis of myofacial pain with impairment will be made. of the ATM, characterizing the mixed DTM.	Volunteers who use a myorelaxant plate, medication such as analgesics and/or anti-inflammatory drugs, pregnant women, temporomandibular joint arthropathy, recent jaw trauma and rheumatoid arthritis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-10v7xxmp	Effect of Visceral Osteopathy on heart rate and pain in patients with Fibromyalgia	Not yet recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5868	Effect of Visceral Osteopathic Manipulative Therapy on heart rate variability and conditional pain modulation in patients with Fibromyalgia - controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Escola de Osteopatia de Madrid	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-10v7xxmp	<NULL>	Female participants;aged between 18 and 65 years; clinical diagnosis of fibromyalgia; persistent or recurrent musculoskeletal pain greater than 12 weeks; symptomatic at the time; motor independence; good understanding of the Portuguese language to answer the questionnaires	Hstory of recent trauma or fractures; tumors or a history of cancer; rheumatologic disease in an acute inflammatory phase; heart disease; use of a pacemaker; pregnant or postpartum women who are breastfeeding during the evaluation or treatment period; cognitive limitations to complete the questionnaires	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-24fcn7p	Different times of administration of Pantoprazole on the control of heartburn in patients with Gastroesophageal Reflux	Recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5869	Effect of Pantoprazole Sodium before lunch versus before breakfast on the control of heartburn in patients with Gastroesophageal Reflux Disease: a pilot study	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-10-13	Universidade Federal da Fronteira Sul	Universidade Federal da Fronteira Sul	https://ensaiosclinicos.gov.br/rg/RBR-24fcn7p	<NULL>	Age greater than or equal to 18 years; both genders; body mass index between 18.5 and 39.9 kg/m2; chief complaint of heartburn (current if not on treatment or controlled with proton pump inhibitor); diagnosis of sliding hiatal hernia (2 cm or more) confirmed by digestive endoscopy	Not having at least three meals a day regularly, including breakfast, lunch and dinner; cognition and communication difficulties; esophagogastric surgery of any nature; pregnant and lactating women; women in the fertile period without using a contraceptive method; alcohol or tobacco abuse (&gt;10 cigarettes/day); decompensated systemic disease (arterial hypertension, diabetes mellitus, cirrhosis, chronic renal failure, lung disease and any infectious condition); not having heartburn after 5 days of discontinuing the proton pump inhibitor (PPI), if using it	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-5y3rpwk	Assessment of food and nutritional security and the food environment in the homes of students from public schools in Mariana and Ouro Preto - Minas Gerais during and after the Covid-19 pandemic	Recruitment completed	Observational	2023-02-06	<NULL>	<NULL>	5870	Assessment of food and nutritional security and the food environment in the homes of students from municipal schools in Mariana and Ouro Preto - Minas Gerais in the Covid-19 pandemic	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-06-15	Universidade Federal de Ouro Preto	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-5y3rpwk	<NULL>	Minimum age of 18 years; both genders; have an active telephone line; reside in the same household as the student; be responsible for buying/preparing food at the student&apos;s home in the municipal network of Mariana or Ouro Preto-MG	Students from Youth and Adult Education (EJA); permanently busy telephone lines; telephone lines with fax signal; telephone lines with answering machine; inability to speak with the person in charge after 5 attempts on alternate days/times	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-3tj2mhr	Influence of Bichectomy on head and neck muscle activity, bite force, salivation, aesthetics and quality of life	Recruitment completed	Intervention	2023-02-06	<NULL>	<NULL>	5871	Influence of Bichectomy on electromyographic and mechanomyographic amplitude of head and neck muscles, bite force, salivary flow, aesthetics and quality of life	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-13	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; - Faculdade de Odontologia de Araçatuba	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"" - Faculdade de Odontologia de Araçatuba"	https://ensaiosclinicos.gov.br/rg/RBR-3tj2mhr	<NULL>	Being aged between 18 and 30 years; having systemic health or at most mild systemic disease (ASA); having complete natural dentition (with at least 28 teeth); good cognitive ability and understanding to answer the questions	Patients classified as class III malocclusion; who used psychotherapeutic; analgesic or chronically used muscle relaxants; were excluded from the study; have no history of tumor; who have had injectable cosmetic procedures and temporomandibular disorders confirmed by the Research Diagnostic Criteria (DC) questionnaire	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-4rrn7cf	Use of whole-body vibration platform for variations in muscle function and functional tasks	Recruitment completed	Intervention	2023-02-06	<NULL>	<NULL>	5872	Effect of frequency used in whole body vibration platform on aspects of muscle function and transfer to functional tasks	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Estadual do Oeste do Paraná (UNIOESTE)	Universidade Estadual do Oeste do Paraná (UNIOESTE)	https://ensaiosclinicos.gov.br/rg/RBR-4rrn7cf	<NULL>	The study will include healthy young adults of both sexes, aged between 18 and 30 years, who do not practice systematic physical activities.	Individuals with neurological and cognitive impairments, cardiorespiratory diseases, and a history of joint and muscle injuries in the last eight months will not participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-4ycx6xp	The Effect of Physical Exercise Performed During Hemodialysis on Blood Pressure, Heart Rate, Oxygenation, Muscle Strength, Fragility and Fatigue of People with Chronic Kidney Disease	Not yet recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5874	Effectiveness of Intradialytic Physical Exercise on Hemodynamic Behavior, Peripheral Muscle Strength, Fragility and Fatigue of Chronic Kidney Patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-03	Universidade Cidade de São Paulo	Fundação Pública Hospital das Clínicas Gaspar Viana	https://ensaiosclinicos.gov.br/rg/RBR-4ycx6xp	<NULL>	Chronic kidney patients aged 18 years and over who undergo hemodialysis at Fundação Hospital de Clínicas Gaspar Viana-FHCGV and Monteiro Leite hemodialysis center; patients with hemodynamic stability, according to the VII Brazilian Guidelines on Arterial Hypertension and the AHA; patients with blood glucose below 250 mg/dl of blood; patients who do not have cardiac arrhythmias and cardiopulmonary limitations; patients with or without neurological and musculoskeletal sequelae, but with muscle strength above grade 3 for the muscles of the upper limbs (large dorsal, pectoralis major and biceps brachii and lower limbs (quadriceps, gluteus, iliopsoas and hamstrings)	Patients who have an arteriovenous fistula in the lower limb; patients who have any level of intellectual and/or psychological disability that may impact the performance of the activities proposed in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-3zj4hgf	Creation of a medication delivery model to improve the treatment of patients with Mental Illness	Recruitment completed	Intervention	2023-02-06	<NULL>	<NULL>	5875	Development of a medication dispensing model to improve the degree of adherence in Psychiatric Patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Universidade Federal de Goiás	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-3zj4hgf	<NULL>	individuals aged 18 years or older; active medical record in the health unit under study; diagnosis of mental disorder in pharmacological treatment; ability to self-administer their medications, being self-declared by the patient	individuals who were unable to understand and answer the questions of the instruments used for data collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-8syxj8r	Evaluation of the impact of Laser application on postoperative pain and healing of the donor area of Gingival Graft: randomized clinical trial	Recruitment completed	Intervention	2023-02-06	<NULL>	<NULL>	5876	Evaluation of the impact of Low-Level Laser on postoperative pain and intensity healing of the donor area and Free Gingival Graft: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-8syxj8r	<NULL>	Patients over 18 years; periodontal health;  to sign of the Declaration of Consent; to present from sites with bleeding to approval of less than 10%.	Individuals who are diabetic; pregnant and lactating; in need of prophylaxis for bacterial endocarditis; using analgesic or anti-inflammatory medication; smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-798j8cr	Effect of telesimulation on teaching and learning of basic in-hospital life support in nursing	Not yet recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5877	Effect of telesimulation on teaching and learning of basic in-hospital life support in nursing: a quasi-experiment	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-798j8cr	<NULL>	Nursing students; age equal to or greater than 18 years; having completed the discipline of Technical Bases of Nursing Assistance of the Nursing Graduation Course	Having contact with in-hospital Basic Life Support for less than 12 months; not having equipment or technological conditions to follow the intervention remotely	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-2qt66fq	Evaluation of implant stability through Torque, Radiography, Resonance Frequency and Peri-Implant Analysis	Recruiting	Intervention	2023-02-06	<NULL>	<NULL>	5889	Evaluation of the stability of external hexagon and morse cone implants through Insertion Torque, Radiographic Analysis, Resonance Frequency and Peri-Implant Condition Analysis	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-07-04	Universidade Paulista	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-2qt66fq	<NULL>	good oral health; needing a single implant in an edentulous space; Type II and III receptor bone	history of periodontal disease; periapical lesion on the tooth adjacent to the edentulous area; need for bone graft; metabolic bone diseases; chronic use of anticoagulants or bisphosphonates; immunocompromised; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:23
RBR-6f2q3my	Assessment of acceptance in use and self-assessment under normal use conditions	Not yet recruiting	Intervention	2023-02-05	<NULL>	<NULL>	5866	Assessment of acceptance in use and self-assessment by the pediatric subject of the study (100222-01), under normal use conditions	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-31	Allergisa Pesquisa Dermato-Cosmetica Ltda	Allergisa Pesquisa Dermato-Cosmetica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-6f2q3my	<NULL>	Healthy pediatric subjects; Intact skin on test site; Agreement of the pediatric subject&apos;s legal guardian to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; Ability by the guardian of consenting to the participation of the pediatric subject in the study; Aged between 2 and 12 years old; Study subjects of any gender; Subjects presenting phototype (Fitzpatrick) I to IV; Users of products of the same category	Skin pathology on the area of product application;Diabetes; Immunological insufficiency; Current use of the following topical or systemic medications: corticosteroids, immunosuppressant and anti-histaminic drugs; Skin diseases: vitiligo, psoriasis, atopic dermatitis; History of reaction to the category of product tested; Other diseases or medications that might directly interfere with the study or put subject&apos;s health under risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-5753p8c	Assessment of acceptance and self-assessment of a nasal spray	Not yet recruiting	Intervention	2023-02-05	<NULL>	<NULL>	5867	Assessment of acceptance in use and self-assessment of a nasal spray (094840-01) under normal conditions of use	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-31	Allergisa Pesquisa Dermato-Cosmetica Ltda	Allergisa Pesquisa Dermato-Cosmetica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5753p8c	<NULL>	Healthy pediatric subjects; Intact skin on test site; Agreement of the child&apos;s legal guardian to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments; Ability by the guardian of consenting to the participation of the child in the study; Children aged from 6 months to 2 years and 11 months; Study subjects of any gender. Subjects presenting phototype (Fitzpatrick) I to IV;Users of products of the same category.	Skin pathology on the area of product application; Diabetes; Immunological insufficiency.Current use of the following topical or systemic medications: corticosteroids, immunosuppressant and anti-histaminic drugs.Skin diseases: vitiligo, psoriasis, atopic dermatitis; History of reaction to the category of product tested; Other diseases or medications that might directly interfere with the study or put subject&apos;s health under risk.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-6d26kcw	Impact assessment of a skin injury prevention protocol on the clinical outcomes of illness care unit patients	Recruitment completed	Intervention	2023-02-03	<NULL>	<NULL>	5859	Impact assessment of a skin injury prevention protocol on the clinical outcomes of critical care unit patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6d26kcw	<NULL>	Age 18 years or older; Admission time in critical care units &lt; 24h; Not having pressure ulcer at the time of the first evaluation; Present score on the Cubbin and Jackson Scale ≤ 29 points; To agree to participate in the study voluntarily or by authorization of caregivers or family members, with the signing of the Free and Informed Consent Form	Develop ulcer pressure during the first 24 hours of stay in the intensive care unit; Patients who are transferred from the intensive care unit to another care unit or other hospital during the first 24 hours of hospitalization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-8974jb6	Fluoride levels in saliva after application of fluoride varnishes	Recruitment completed	Intervention	2023-02-03	<NULL>	<NULL>	5860	Salivary fluoride bioavailability after the use of fluoride varnishes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8974jb6	<NULL>	Favorable oral and systemic conditions; availability to participate in the research and comply with the determinations required by the experimental protocol; normal salivary flow; both genders; from 20 to 32 years old	use of medications that alter salivary flow; fluoride supplements; smokers; presence of active carious lesion;  periodontal disease; fixed orthodontic appliance; allergy or sensitivity to the ingredients of the study varnishes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-103yt9mm	Facelift surgery in post-bariatric surgery patients	Data analysis completed	Intervention	2023-02-03	<NULL>	<NULL>	5861	Rhytidectomy with and without SMAS plicature in post-bariatric surgery patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-01	Escola Paulista de Medicina	Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-103yt9mm	<NULL>	Female patients; aged between 40 and 70 years-old; post-bariatric surgery; with stable weight for at least 3 months; presenting with complaints of rhytidosis and skin sagging in the face.	Patients previously submitted to facial surgery; implants or cosmetic procedures (either physical or chemical in the last 12 months); recent or uncontrolled clinical conditions (such as diabetes and hypertension); disorders of wound healing; autoimmune or collagen disorders; psychiatric conditions, smokers; patients in use of anticoagulant medications; corticosteroids; history of hypersensitivity to anesthesia; illiteracy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-10y32ztc	Effect of an intervention performed by telephone on the self-efficacy of adolescents&apos; with type 1 diabetes	Recruitment completed	Intervention	2023-02-03	<NULL>	<NULL>	5862	Effect of an Educational Intervention on the type 1 Diabetes Mellitus adolescents&apos; self-efficiency	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-04	Universidade Estadual do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10y32ztc	<NULL>	Adolescents aged between 14 and 19 years old diagnosed with Diabetes Mellitus type 1 for at least six months; accompanied regularly in the service; with phone access	Adolescents who had any cognitive or behavioral difficulties that prevented communication from effectively participating in the interview	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-5hcts9p	Effects of stretching via telehealth in community-dwelling older adults	Recruiting	Intervention	2023-02-03	<NULL>	<NULL>	5863	Effects of Active-Fascial Stretching via telehealth in community-dwelling Older Adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-30	Universidade São Judas Tadeu	Universidade São Judas Tadeu	https://ensaiosclinicos.gov.br/rg/RBR-5hcts9p	<NULL>	Independent seniors; absence of severe impairment of systems such as impairment of the auditory, vestibular, proprioceptive, neurological or musculoskeletal systems; absence of joint range of motion limitation; not using medications that could alter postural balance; not presenting cognitive impairment; familiar with the use of the internet and applications; have internet; having a cell phone or tablet or computer to watch and practice classes; mandatory presence of a family member to accompany you during class; be a resident of the city of São Paulo or surrounding cities.	dependent elderly; severe system impairment such as auditory, vestibular, proprioceptive, neurological, or musculoskeletal impairment; limitation of range of joint movement; making use of medications that may alter postural balance; present cognitive deficit; not being familiar with the use of the internet and applications; not having internet; not having a cell phone or tablet or computer to watch and practice classes; not having a companion during class; not be a resident of the city of São Paulo or surrounding cities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-8rwx89c	Impact of different educational strategies for teaching empathy to medical students	Recruiting	Intervention	2023-02-03	<NULL>	<NULL>	5864	Impact of different educational strategies for teaching empathy to medical students: a randomized controlled trial in education	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-03	Faculdade de Medicina da Universidade Federal de Juiz de Fora	Faculdade de Medicina da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8rwx89c	<NULL>	Students who are enrolled in the ninth period at the Faculty of Medicine of the Federal University of Juiz de Fora (FAMED-UFJF); to participate in the activities of groups 1 and 2 according to randomization.	Absence for any reason during the intervention; not regularly registered in the 9th semester of the School of Medicine at the Federal University of Juiz de Fora	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-8v9gr9c	Effectiveness of Ice application in acute ankle sprain treatment	Recruiting	Intervention	2023-02-03	<NULL>	<NULL>	7725	Effectiveness of Cryotherapy on function, pain intensity, swelling, dorsiflexion range of motion in Acute Ankle Sprain: a randomized controlled trial - the frost study	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-03-03	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Hospital Nossa Senhora da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-8v9gr9c	<NULL>	People of both sexes aged between 18-60 years old; clinical diagnosis of grade I or II ankle sprains, indicating an incomplete ligament rupture; time of up to 72 hours from the episode of the injury to the day of the medical appointment; bone fractures excluded by radiography or by the Ottawa ankle rules	Grade III (severe) ankle sprain, indicating complete ligament injury, determined by a clear positive test of the anterior drawer and / or inversion stress test, accompanied by severe swelling, hemorrhage, high level of pain on palpation, in addition to total loss of the ability to support weight on the foot and of the dorsiflexion range of motion; open injuries that contraindicate the application of ice; having applied some form of cryotherapy more than once since the moment of the injury until the allocation process; apply some form of cryotherapy after being assigned to the control group; have any conditions that contraindicate the application of ice (e.g. Raynaud&apos;s syndrome), or any other intervention prescribed in this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:31
RBR-4n6rqyj	Device Development for a Diagnostic Procedure in Liver Diseases	Data analysis completed	Intervention	2023-02-02	<NULL>	<NULL>	5858	Development of a Device for Performing Biopsy Video-Assisted Liver	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Instituto para O Desenvolvimento da Educação Ltda.	Instituto para O Desenvolvimento da Educação Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-4n6rqyj	<NULL>	Patients with moderate to severe hepatic steatosis, submitted to abdominal laparoscopic surgery for another underlying disease; Patients who needed a liver biopsy for etiological confirmation or staging of disease activity	Refusal to participate in the study: Patients diagnosed with hepatocellular carcinoma (HCC) AND The following risk factors: Patients with INR &gt; 1.8 and/or platelets &lt; 70,000/mm3; Patients diagnosed with hepatocellular carcinoma (HCC); Patients with coagulopathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-3qfbw73	Effectiveness, safety and tolerability of Passion Fruit Peel in the control of type 1 Diabetes Mellitus	Recruiting	Intervention	2023-02-02	<NULL>	<NULL>	6676	A phase II,randomized, double-blind, placebo-controlled clinical study to evaluate the effectiveness, safety and tolerability of the Extract of the Pericarp of Passiflora edulis in the glycemic control of type 1 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-3qfbw73	<NULL>	Both sexes aged between 18 and 60 years; type 1 diabetes mellitus diagnosis at least two years ago; absence of C-peptide; glycated hemoglobin between 7% and 10%; patients without significant changes in insulin dose (&lt;10% of the number of daily units) in the last eight weeks; agreeing to participate in the trial by signing the informed consent form	Illiterate; pregnant or breastfeeding; inability to follow research protocol; hypothyroidism; hyperthyroidism; Alzheimer&apos;s; Parkinson&apos;s; Schizophrenia; renal insufficiency; anemia; obesity (BMI&gt; 30 kg /m2); hemoglobinopathy; acute liver disease; chronic liver disease; unit of alcohol per week: &gt; 21 men and &gt; 10 women; consumption of 1 or more cigarettes per day; phytotherapy; non-steroidal anti-inflammatory drugs, opiates and corticosteroids; juices or other foods based on passion fruit (P. edulis); food supplements containing passion fruit (P. edulis) in the composition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:51
RBR-10ny848z	Functional Training, Immune System, and Physical Function of older women	Recruitment completed	Intervention	2023-02-01	<NULL>	<NULL>	5856	Functional Training, Immunosenescence, and Functionality of older women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-30	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-10ny848z	<NULL>	Participants eligible should be 65 years of age or older; be physically independent; have no cardiovascular or musculoskeletal comorbidities, as well as no uncontrolled conditions that preclude physical exercise; not be on hormone replacement therapy; no regular physical activity or exercise, this is two or more times per week in the six months prior to the beginning of the study	Participants who are participating in regular exercise programs; or consuming dietary supplements	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-106xbn9s	GDF-15 levels as prognostic marker in patients with Atrial Fibrillation	Recruitment completed	Observational	2023-02-01	<NULL>	<NULL>	5857	Growth differentiation factor-15 in Assessment of Prognosis of patients with Atrial Fibrillation (GAP-AF Study)	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-04-10	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-106xbn9s	<NULL>	Hospitalized patients with a primary or secondary or secondary diagnosis of acute, paroxysmal or permanent Atrial Fibrillation; aged 18 years or older.	Presence of associated terminal disease (malignant neoplasms or others); pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:22
RBR-10bhvcr4	Salivary fluoride levels after brushing with high fluoride toothpaste	Recruitment completed	Intervention	2023-01-31	<NULL>	<NULL>	5850	Bioavailability of salivary fluoride after brushing with high-fluoride dentifrice	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-10bhvcr4	<NULL>	Adult individuals. Good systemic health. Good oral health. Normal salivary flow.	Smokers. Presence of active caries. Periodontal disease. Orthodontic patients. Pregnant. Nursing mothres.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-78s7nmn	Behavioral profile of patients with chronic back pain	Recruiting	Intervention	2023-01-31	<NULL>	<NULL>	5851	Behavioral profile of patients with Central Sensitization after Biopsychosocial Treatment	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-30	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-78s7nmn	<NULL>	Chronic low back pain; Risk os central sensitization; More than 18 years; Pain intensity superior to three; both sexes	Cognitive decline; Red flags; Nerve root impairment; cardiorrespiratory disease; Body mass index superior to 35 kg/m2; Pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-9kgvft8	Post-Covid impacts on physical function and well-being	Recruitment completed	Intervention	2023-01-31	<NULL>	<NULL>	5852	Post-Covid impact on functionality and well-being	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Presbiteriana Mackenzie	Universidade Presbiteriana Mackenzie	https://ensaiosclinicos.gov.br/rg/RBR-9kgvft8	<NULL>	Both sexes; aged 18 to 75 years; normal or corrected vision; with previous diagnosis of COVID-19; Only for study 3 - the participant needs to be clinically stable; oxygen saturation &gt; 93%; respiratory rate of at least 12-20 breaths per minute (pmI); heart rate of 60 to 110 breaths per minute (bpm)	participants who have inability to fully or fully understand the instruments used in this project; participants with myopathies; diseases with peripheral demyemyellinization; malnutrition; neoplasms in treatment; anorexia; chronic kidney diseases; liver disease; or any other disease that promotes sarcopenia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-9vvb89s	Vaccination against Hepatitis B in people with Chronic Kidney Disease before or after the Hemodialysis procedure: Randomized Clinical Trial	Recruitment completed	Intervention	2023-01-31	<NULL>	<NULL>	5853	Vaccination against Hepatitis B in Chronic Kidneys before or after Hemodialytic treatment:Randomized Clinical Trial	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2022-07-15	Programa de Pós Graduação em Enfermagem	Programa de Pós Graduação em Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-9vvb89s	<NULL>	Chronic renal patients aged 18 to 40 years who undergo hemodialysis who are previously non-reactive (anti-HBS less than 10 UI/mL) will be included	Systemic lupus erythematosus; malignant neoplasm; hepatitis B; AIDS and use of immunosuppressive drugs will be excluded; history of allergic reaction to the Hepatitis B vaccine or any of its components; patients with serology bigger then 10UI/mL in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-9hw4vbs	Comparison between Myofascial Release Instruments in reducing muscle pain in runners	Recruitment completed	Intervention	2023-01-30	<NULL>	<NULL>	5847	Comparison between Instrumental Myofascial Release Devices in relieving delayed muscle pain in runners	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-19	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9hw4vbs	<NULL>	Healthy volunteers; both genders; age between 18 and 49; who have been running for more than 6 months	Participants who are using analgesics; pregnant or postpartum women; with active infectious processes; inability to understand instructions or consent to the study; with the presence of auditory, visual or communication disorders; who have moderate or severe cognitive/psychiatric disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-10x4hys8	Assessment of blood levels of triglycerides after eating and their relationship with the risk of suffering heart disease	Recruitment completed	Observational	2023-01-30	<NULL>	<NULL>	5848	Postprandial triglyceride and cardiovascular risk	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2016-04-01	Universidade Federal Fluminense - Instituto de Saúde de Nova Friburgo	Sociedade União Beneficente Humanitária dos Operários	https://ensaiosclinicos.gov.br/rg/RBR-10x4hys8	<NULL>	Residing in the mountainous region of the state of Rio de Janeiro; Attend the Sociedade Beneficente Humanitaria dos Operarios; Men; Women; Over 18 years	Who do not adhere to the experimental protocol or do not attend one of the planned visits; who use lipid lowering drugs; carriers of genetic disorders that affect lipid metabolism; who are on an energy restricted diet or some macronutrient at the time of the study or in the last two months prior to the study; strict vegetarians, lactovegetarians and ovolactovegetarians; who regularly consume two or more doses of alcoholic beverages 5 grams of alcohol; under 18 years old; mentally disabled	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-357qcdh	Evaluation of the association of Ozone to Dental Bleachening treatment	Recruiting	Intervention	2023-01-30	<NULL>	<NULL>	5849	Clinical and laboratory evaluation of the association of the Ozone to Hydrogen Peroxide in office Bleaching treatments	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-16	Instituto de Ciência e Tecnologia de São José dos Campos (ICT) - Unesp	Instituto de Ciência e Tecnologia de São José dos Campos (ICT) - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-357qcdh	<NULL>	18 years of age or older; possess all permanent maxillary anterior teeth healthy; present A2 staining on the VITA Classical scale (universal color classification used for measuring and defining the color of teeth in aesthetic treatments) or darker; availability for periodic returns	Present allergy to bleaching agents; start orthodontic treatments; perform restorative procedures on the vestibular surface of the anterior teeth; not completing the whitening treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-8sxnfyd	Effects of Exercise during hospital stay in pediatric Cancer patients	Recruiting	Intervention	2023-01-25	<NULL>	<NULL>	5842	Protocol of Therapeutic Exercises during hospital admission in pediatric Oncohematological patients: a randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Centro Universitário Faculdade de Medicina do ABC	Centro Universitário Faculdade de Medicina do ABC	https://ensaiosclinicos.gov.br/rg/RBR-8sxnfyd	<NULL>	Individuals between 8 and 17 years old; with diagnosed oncohematological disease; hospitalized in a pediatric ward; both sexes; clinically compensated participants with respiratory, cardiac or musculoskeletal pathologies prior to cancer diagnosis; that they accept to participate in the research and those responsible sign the informed consent form and that the participant signs the informed consent form	Participants with cognitive alterations that make the assessment impossible; participants who present one or more of the following criteria: body temperature &gt; 38ºC, pain with a visual analogue pain scale  of 5 or above, constant diarrhea, uncontrolled bleeding, tachycardia and/or hypotension (mean arterial pressure - MAP less than 60); participants with blood count alterations less than 8.0mg/dl and symptoms of decompensation and platelets less than 20.000/mm3	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-103nyv5v	Effects of an Exercise session performed on stationary bicycle on cognitive function and cerebral blood vessel function in patients with Parkinson&apos;s disease	Recruiting	Intervention	2023-01-25	<NULL>	<NULL>	5843	"Aerobic Exercise effects on cognitive and cerebrovascular functions on patients with
Parkinson Disease"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade Nove de Julho	Associação Brasil Parkinson	https://ensaiosclinicos.gov.br/rg/RBR-103nyv5v	<NULL>	previous diagnosis of Parkinson&apos;s Disease; being undergoing pharmacological treatment for Parkinson&apos;s Disease; be at least 50 years old	being in Hoehn &amp; Yahr stages 4 or 5 of Parkinson&apos;s Disease; presenting other neurological diseases in addition to Parkinson&apos;s disease; present electrocardiographic alterations during exercise test suggestive of cardiovascular pathology; having a diagnosis of cardiovascular disease, cancer, or any type of dementia; score ≤ 20 on the “Montreal Cognitive Assessment (MoCA)”; be performing aerobic training regularly; have musculoskeletal problems that interfere with performing aerobic exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-3tvjjkx	Treatment of non-motor symptoms of Parkinson&apos;s disease with Cannabidiol	Recruiting	Intervention	2023-01-25	<NULL>	<NULL>	5844	Treatment of non-motor symptoms of Parkinson&apos;s disease with purified extract of Cannabis sativa	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-11-01	Hospital da Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital da Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3tvjjkx	<NULL>	Over 25 years of age; Diagnosis of Parkinson&apos;s Disease according to Movement Disorder Society criteria; Present pain related to Parkinson&apos;s disease according to the criteria of the Parkinson Disease Pain Classification System Questionnaire; Suffer from chronic pain  according to the definition of chronic pain recommended by the 11th edition of the International Classification of Diseases; Able to provide informed consent; Have easy access to a telephone	"Allergy any component of the studied test solutions;Patients using medications with a narrow therapeutic index, and clinically relevant risk due to significant pharmacological interactions with medication studied; Clinically relevant current liver disease, at the discretion of the investigators, and/or hepatitis C; Concomitant use of valproic acid and/or its derivatives;
Personal history of schizophrenia and/or bipolar affective disorder; History of psychotic symptoms not justified by Parkinson&apos;s Disease; History of suicidal ideation, planning and/or attempt; Research subjects who will not be able to attend to the trial&apos;s follow-up assessments; Subjects who do not understand Portuguese; Women of childbearing age, unless they are using an Intrauterine Device or had been previously submitted to tubal ligation; Severe non-compensated psychiatric comorbidities, at the discretion of the researchers; Severe non-compensated clinical comorbidities, at the discretion of the researchers; Pregnant or breastfeeding women; Use in the past 2 years of Cannabis sp. and/or its derivatives for recreational or therapeutic purposes; Personal history of cannabis use disorder and/or other illicit drugs; Personal history  of alcohol, tobacco, opioid, benzodiazepine, barbiturate and/or other substance use disorder"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-6vymyxs	Training of the Pelvic Floor for the treatment of Stress Urinary incontinence in the of teleconsultation	Recruiting	Intervention	2023-01-25	<NULL>	<NULL>	5845	Training of the muscles of the Pelvic Floor for the treatment of Stress Urinary incontinence in the modality of teleconsultation and telemonitoring	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-16	Centro Universitário São Camilo	Centro Universitário São Camilo	https://ensaiosclinicos.gov.br/rg/RBR-6vymyxs	<NULL>	access to the internet and a device (cell phone, computer and/or tablet); ability to use the device; have a headset to use during calls; and have a private space for the sessions.	women who do not meet the inclusion criteria (domain and/or do not have access to the internet; do not have a headset or a private place to hold the session); reporting chronic degenerative diseases, pelvic organ prolapse greater than grade II (according to the participant&apos;s report), urinary tract infection, neurological or psychiatric disease; who underwent pelvic floor muscle training and/or treatment of urinary incontinence previously; and with inability to answer the questionnaires properly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-58q5y2m	Methylpredniprednisolone on ICU patients with COVID-19 on mechanical ventilation	Data analysis completed	Intervention	2023-01-24	<NULL>	<NULL>	5840	Evaluation of Methylprednisone use in patients with Acute Respiratory Syndrome by COVID-19	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2020-07-07	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-58q5y2m	<NULL>	over 18 years old ; COVID-19 ; mechanical ventilation within 24 hours; Acute Respiratory Distress Syndrome	pregnancy; active lactation; history of methylprednisolone allergy; corticosteroid use in the past 15 days; informed consent refusal; expected death in the next 24 hours	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-2ntr3yd	Evaluation of vaginal atrophy symptoms and sexual function in Breast Cancer Survivors after local treatment with Radiofrequency	Not yet recruiting	Intervention	2023-01-24	<NULL>	<NULL>	5841	Evaluation of vaginal microbiota and sexual function after Microablative Fractional Radiofrequency for the Genitourinary Syndrome of Menopause in Breast Cancer suvivors	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2ntr3yd	<NULL>	Women with nonmetastatic breast cancer; age 45 to 65 years; sexually active; with genitourinary symptoms	Women with recurrent or metastatic cancer; prior reconstructive pelvic surgery for prolapse; use any form of hormonal therapy in the last six months; use of lubricants or moisturizers in the past month; the presence of genital infections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-9kkmchk	Evaluation of Individualized Mouthguards made of different materials and the Effect on the Preference and Wearability of athletes	Recruiting	Intervention	2023-01-24	<NULL>	<NULL>	6040	The effect of different Ethylene-Vinyl Acetate (EVA) brands for applied for Custom-Fitted Mouthguards on the Preference and Wearability during sports practice: A randomized crossover clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-9kkmchk	<NULL>	To be a high-performance football athlete; To have a training routine of at least 5 days a week with a daily workload of 4 hours; To present good oral health, without the need for treatments; To have a minimum age of 16 years and be in permanent dentition with all teeth present (except third molars, which will be considered an exception in this criterion)	Not being under orthodontic treatment; Have missing teeth; Have a history of using mouthguards; Show inability to attend the 4 (four) meetings with the research team (for molding, delivery of individualized mouthguards and evaluations); Having difficulties using mouth guards in the stipulated period due to the competition calendar; Present subjective factors that make the use of mouthguards unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-23dgvk8	Effects of Osteopathic Manipulation Techniques on treatment of patients with Stroke	Recruiting	Intervention	2023-01-23	<NULL>	<NULL>	5839	Effects of Osteopathic Manipulation Techniques on treatment of patients with Brain Stroke Ischemic	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Escuela de Osteopatia de Madri - Brasil Ltda	Escuela de Osteopatia de Madri - Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-23dgvk8	<NULL>	Men and women with a clinical diagnosis of up to 60 days after ischemic cerebrovascular insult in the middle cerebral artery; present an age group between 40 and 55 years; being in physical therapy treatment in a rehabilitation establishment neurofunctional; agree and sign the Free and Informed Consent Term	Present a stroke resulting from covid-19; associated neurological disease; infectious diseases; active autoimmune diseases; hemorrhagic stroke; previous history of stroke; deafness or significant hearing loss; and patients with cognitive disorders that impede the understanding of the questionnaires; untreated systemic arterial hypertension; pregnancy; smoking; alcoholic; not using antibiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-2dm7t97	Use of Laser and Antimicrobial Dyes in the treatment of infected ulcers in people with Diabetes Mellitus: a Randomized Clinical Trial	Recruiting	Intervention	2023-01-23	<NULL>	<NULL>	6273	Photodynamic Therapy in the treatment of foot ulcers in people with Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-05-22	Escola de Enfermagem de Ribeirão Preto - Universidade de São Paulo	Escola de Enfermagem de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2dm7t97	<NULL>	Patients aged 18 years or older; Diagnosis of Diabetes (recorded in medical records or supporting test); have foot ulcers; agreeing to perform a biopsy of the lesion; being available to attend the outpatient clinic, on pre-established days, during six weeks of treatment + an additional week for evaluating the outcomes.	Patients using immunosuppressive drugs; diagnosis/treatment of neoplasms; Chronic Renal Failure; Peripheral Vascular Insufficiency; Suspected or confirmed osteomyelitis; lesion with an area larger than 10x12 centimeters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-6m7tyhf	Effect and safety of 5% nicotinamide cream in the treatment of actinic keratosis	Recruiting	Intervention	2023-01-20	<NULL>	<NULL>	5838	Efficacy and safety of 5% nicotinamide cream in stabilizing the skin field cancerization: a randomized, double blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-09	Faculdade de Medicina Julio de Mesquita Filho	Fundo de Apoio à Dermatologia	https://ensaiosclinicos.gov.br/rg/RBR-6m7tyhf	<NULL>	Sign the Free and Informed Consent Form; age over 18 years of both sexes; present at least three and at most ten lesions clinically compatible with actinic keratoses on each forearm, bilaterally.	Actinic keratoses fewer than three or more than ten on each forearm; selected treatment area that has atypical clinical appearance or other extensive dermatoses on the forearms; presence of skin tumors in the treatment area; current and previous clinical diagnosis or evidence of any medical condition that exposes the patient to increased risks, interferes with the safety or efficacy of the proposed treatment; present hypersensitivity or allergy to any of the substances being studied; patients using any systemic or topical immunosuppressant substance and oral retinoid; immunocompromised individuals; coagulation disorders; suspected or confirmed pregnancy; women of childbearing age not using contraceptive methods; breastfeeding women; previous treatments for actinic keratoses in the last six months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-4h3chsp	Analysis of anti-inflammatory and anti-pain effects of Black Sesame Oil on performance of day-to-day functions and pain intensity in adults with Low Back Pain	Not yet recruiting	Intervention	2023-01-20	<NULL>	<NULL>	5971	Analysis of anti-inflammatory and antinociceptive effects of Subcritical Extract of Black Sesame (Sesamum Indicum L.) on functional performance and pain intensity in adults with Low Back Pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-01	Universidade Federal do Oeste do Pará	Universidade Federal do Oeste do Pará	https://ensaiosclinicos.gov.br/rg/RBR-4h3chsp	<NULL>	Adults of both sexes; be in the age group between 18 and 55 years; peoples confirmed with the presence of low back pain; present functional impairment and limiting pain due to low back pain; staying one day prior to the start of the study intervention without performing any type of treatment for low back pain; have consent, voluntarily, through the Free and Informed Consent Term (ICF)	"Presence of neoplastic, infectious, neurological, severe progressive orthopedic, rheumatic 
or autoimmune conditions; fibromyalgia diagnosis; presence of decompensated metabolic and/or cardiorespiratory disorders; pregnancy status; obesity; compression fracture of the spine; candidates for neurosurgery or orthopedic surgery; use of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, analgesics, muscle relaxants, psychotropic drugs and/or some other specific treatment for low back pain during the study intervention; previous surgery on the lumbar spine; to present changes in cognitive functions that make it impossible to proceed with the study treatment"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-95x5kmk	Effect of Electrical Stimulation of the brain associated with Physical Exercise for hip Tendonitis and Bursitis	Recruitment completed	Intervention	2023-01-20	<NULL>	<NULL>	6719	Effect of Transcranial Direct Current Electric Stimulation associated with Physical Exercise in patients with Greater Trochanteric Pain Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-30	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-95x5kmk	<NULL>	Voluntaries with greater trochanteric pain syndrome; older than 18 years old; from both genders	Motor or cardiovascular impairment precluding physical exercise; uncontrolled epilepsy; extensive skin lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-5qynxgg	Access bar therapy as a treatment proposal for subjects with chronic Tinnitus	Recruitment completed	Intervention	2023-01-19	<NULL>	<NULL>	5832	Chronic tinnitus: Analysis of therapy with Access Bar as a treatment proposal	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-10	Universidade Federal de Santa Maria -UFSM	Universidade Federal de Santa Maria -UFSM	https://ensaiosclinicos.gov.br/rg/RBR-5qynxgg	<NULL>	Subjects with normal hearing thresholds or sensorineural hearing loss to a moderate degree; subjects with hearing loss in isolated frequencies; both genders; tinnitus with unilateral or bilateral perception of at least six months; tinnitus of different causes; age between 18 and 60 years old; Analogic visual scale minimum score of five.	Subjects with neurological or psychiatric problems reported in the anamnesis and researched in individual medical records; external or middle ear alterations; subjects who are undergoing any treatment for tinnitus.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-6789t4v	Brazilian trial of Amantadine for disorders of consciousness after intracranial bleeding due to aneurysm rupture	Recruiting	Intervention	2023-01-19	<NULL>	<NULL>	5834	Amantadine for disorders of consciousness after Aneurysmal Subarachnoid Hemorrhage	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2020-01-20	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital Universitário Cajuru da Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6789t4v	<NULL>	Patients with spontaneous subarachnoid hemorrhage due to cerebral aneurysm rupture; adults; both genders	Unfavorable previous baseline neurological status, defined as modified Rankin Scale (mRS) greater than 2; pediatric patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-97kx5jv	An Alksite Composite material to Restore Endodontically Treated Teeth: A randomized control trial study	Data analysis completed	Intervention	2023-01-19	<NULL>	<NULL>	5835	Evaluation of a Bioactive Composite for the Restoration of Endodontically Treated Teeth: A Prospective Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo - FORP USP	Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo - FORP USP	https://ensaiosclinicos.gov.br/rg/RBR-97kx5jv	<NULL>	Both genders; Presence of 1 lower molar (First or Second) treated endodontically requiring direct restoration; Endodontic treatment performed for a maximum of 6 months; Presence of antagonist tooth in the dental arch; No parafunctional habits; No temporomandibular disorder; age 18 to 40 years	Teeth with extensive loss with indication of indirect restorations were excluded from the study; teeth with root involvement such as fractures or cracks, patients with poor oral hygiene, patients with chronic or aggressive periodontitis, teeth that were endodontically treated for more than 6 months and teeth without provisional cavity sealing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-2xfd7d9	Rehabilitation with Games at home for people with Sequelae of Poliomyelitis and Post-Polio Syndrome	Recruiting	Intervention	2023-01-19	<NULL>	<NULL>	5836	Virtual Reality Games as a possibility of Telerehabilitation for Individuals with Poliomyelitis sequel and Postpoliomyelitis Syndrome	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2xfd7d9	<NULL>	Individuals of male and female gender, no age restriction that have a confirmed diagnosis of Poliomyelitis and/or Post Poliomyelitis Syndrome; Agree to participate in the study by signing the Free and Informed Consent Form (FICT); Being able to raise the upper limbs above the shoulder line; Possess technology devices to perform the virtual task (computer or tablet) and to contact the researcher (cell phone)	Individuals who have some cardiorespiratory and cognitive impairment that prevents the understanding and performance of tests and exercises such as: Tachycardia; tracheostomized individual; continuous use of non-invasive ventilation devices and invasive ventilation; dementias of any kind, Alzheimer&apos;s diagnosis; diagnosis of Parkinson&apos;s disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-8zmxfnp	Modification of Hand Strength induced by opposite Wrist Strength and Acupuncture	Data analysis completed	Intervention	2023-01-19	<NULL>	<NULL>	7762	Modification of Palmar Grip Strength induced by Overflow of non-homologous muscles and Acupuncture at points HT3 (ShaoHai) and HT7 (ShenMen)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-30	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8zmxfnp	<NULL>	Healthy volunteers; both genders; age between 18 and 30 years; right motor preference	Diagnosis of orthopedic pathologies; pain in upper limbs; fear of needles; pregnant women; women with delay in menstrual cycle longer than 28 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:32
RBR-48bhsdx	Effects of Heated Blanket on Premature babies	Recruiting	Intervention	2023-01-18	<NULL>	<NULL>	5831	Effects of Thermal Blanket in Premature newborns: a randomized controlled clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-18	escola de enfermagem Anna Nery	hospital universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-48bhsdx	<NULL>	Premature newborns below 34 weeks up to 25 weeks of Gestational Age; low and very extreme low weight; in ventilatory assistance or not; normothermic or hypothermic, with vital functions in the normal range	Newborns received from another institution, at term, post-term, malformed, asphyxia who present dysthermia of central origin, hyperthermia and hemodynamic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-10242sbz	Effect of intraoral and extraoral Photobiomodulation Therapy in the treatment of oral mucosal diseases	Not yet recruiting	Intervention	2023-01-18	<NULL>	<NULL>	6930	Intraoral and extraoral Photobiomodulation Therapy in the treatment of common oral mucosal diseases: basket trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2023-07-01	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10242sbz	<NULL>	volunteers; diagnosed with oral lichen planus or burning mouth syndrome; treatment-naive; both genders; minimum age of 18 years	patients with oral lichen planus diagnosed with gastrointestinal ulcer; decompensated systemic arterial hypertension and/or decompensated diabetes mellitus	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:01
RBR-8k98md3	Effect of adding Self-Efficacy Strategies to Strengthening Exercises and Manual Therapy on functionality and self-efficacy of patients with shoulder pain: a randomized controlled trial with economic evaluation	Recruitment completed	Intervention	2023-01-18	<NULL>	<NULL>	8200	Efficacy of adding Self-Efficacy Strategies to Strengthening Exercises and Manual Therapy for disability and self-efficacy of individuals with chronic shoulder pain: a randomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8k98md3	<NULL>	Individuals who have one of the following diagnostic terms “Anterior shoulder pain”; “Subacromial Impingement Syndrome”; “Subacromial Impingement Syndrome”; “Painful shoulder”; “Shoulder Tendinitis” or specific rotator cuff tendonitis; “Subacromial bursitis” or “Subdeltoid bursitis” in the diagnostic field; Both sexes; Age from 18 years old; Shoulder pain for more than 12 weeks; 3 or more positive findings in the “Painful arch in flexion or abduction” tests; “Neer”; “Hawkins-Kennedy Test”; “pain on resisted external humeral rotation” or “Jobe&apos;s Test”	Previous history of shoulder surgery or injuries caused by external forces; full-thickness tear of the rotator cuff as evidenced by imaging (US or MRI); shoulder instability; adhesive capsulitis; or if they are involved in cognitive-behavioral and cognitive-functional therapy due to conflicting literature on possible changes in self-efficacy in this population; Cardiovascular and neurological disorders including cervical and arm nerve entrapment syndromes; pregnant women; those who are unable to perform the required clinical assessment tasks, answer the questionnaires, or attend the required assessment and intervention sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:47
RBR-6t95ghw	Strengthening Exercises in Patients with Patellofemoral Pain	Recruiting	Intervention	2023-01-17	<NULL>	<NULL>	5828	Single or Multi-Joint Strengthening Exercises in Patients with Patellofemoral Pain: A Pilot Study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Centro Universitário São Camilo	Centro Universitário São Camilo	https://ensaiosclinicos.gov.br/rg/RBR-6t95ghw	<NULL>	Both genders; 18 to 45 years of age; history of prior knee pain for at least 3 months during the following activities: prolonged sitting, walking up or down stairs, squatting, running or jumping, as well as a minimum of 3 points on the Visual Analog Scale.	History of lower limb surgery; chronic knee instability; disorders associated with meniscal or ligament injuries; cardiac or locomotor conditions that could affect the performance of the treatment program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-4mm5xd3	Effects of rest on low back strength in healthy adults and with chronic non-specific low back pain	Recruiting	Intervention	2023-01-17	<NULL>	<NULL>	5829	Effects of the recovery interval on the strength of the trunk extenders in healthy adults and with chronic non-specific low back pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-22	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4mm5xd3	<NULL>	Civilians from the Federal District and surroundings; Healthy people; Diagnosed with chronic non-specific low back pain; Men; Individuals between 18 and 55 years old; Be physically fit and willing to complete training sessions	Classifieds with a red flag (medical emergency); Signs of infection or inflammation in the spine, and in the lower and upper extremities in the last 3 months; Postoperative period of chest and abdomen less than 6 months; Trauma or surgery to the spine; Fibromyalgia; Rheumatological or myopathic diseases; Uncontrolled cardiovascular disease; Neurological disease; People who have undergone physiotherapeutic treatment for the spine or who have performed it during the last 3 months; Persons who are away from work for medical reasons.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-57c9wnd	Prebiotic and functional effects of Ora-pro-nobis (Pereskia aculleata) in overweight women	Not yet recruiting	Intervention	2023-01-17	<NULL>	<NULL>	5830	Effects of Ora-pro-nobis (Pereskia aculleata) on female health	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-15	Universidade Vila Velha	Universidade Vila Velha	https://ensaiosclinicos.gov.br/rg/RBR-57c9wnd	<NULL>	Volunteer women; age between 18-59 years; diagnosed with overweight or obesity by BMI&gt;24.5;	Disease diagnosis; consumption of food supplements in the last 6 months; consumption of laxatives in the last 6 months; consumption of antibiotics in the last 6 months; surgical procedures in the last 6 months; vegetarianism; consumption of herbal remedies; consumption of herbal preparations; known allergic reactions to product components; intake of probiotics in the previous year; use of hypoglycemic drugs; use of lipid-lowering drugs; use of hypotensive; presence of other comorbidities; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-2txw8zy	Effects of the Aquatic Exercise Training on Health of Adults and Elderly	Recruiting	Intervention	2023-01-17	<NULL>	<NULL>	6580	Effects of the Aquatic Training in Upright Position on Hemodynamic, Metabolic, Functional and Psychosocial Outcomes in Adults and Elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-11	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-2txw8zy	<NULL>	Be a participant in the Vertical Position Water Activities program; have medical authorization to practice physical exercise	Do not be disponible time for participate; have osteomioarticular limitations that may impair the execution of the exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:18
RBR-8jbhzsz	Relations between physical activity, sleep and screen time and health condition of preschoolers in Petrolina – PE city – the movement’s cool project	Recruitment completed	Intervention	2023-01-16	<NULL>	<NULL>	5825	Transversal and longitudinal relations between 24 hour movement behaviours and health outcome in preschoolers of Petrolina PE city – the movement’s cool project	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-15	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-8jbhzsz	<NULL>	Children aged between 3 and 5 years;  enrollmented in public preschool in Petrolina city (PE)	Transfer to another preschool during the study; neurodevelopmental disorders; participant in structure physical activity, such as sport and similar; low frequency of class attendance	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-3qqr4yk	Impact of turmeric intervention on vascular endothelium function, oral health and markers of inflammation and oxidative stress: establishment of the importance of phytotherapy in public health and in the treatment of type 2 Diabetes Mellitus	Recruiting	Intervention	2023-01-16	<NULL>	<NULL>	5826	"Impact of intervention with Curcuma longa L. on endothelial function, health
oral and inflammatory and oxidative stress markers: establishment of
importance of phytotherapy as an integrative practice in the treatment of Diabetes Mellitus
of type 2"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-20	Universidade Federal de São Paulo	"Universidade Estadual Paulista ""Julio Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-3qqr4yk	<NULL>	Volunteers with Type 2 Diabetes Mellitus; patients at the Birigui Specialty Center, São Paulo; both genders; age between 40 and 70 years	Volunteers with walking difficulties and/or who cannot get on the platform scale; current or recent use of antibiotics and anti-inflammatories (3 months); who make or have recently used (last 6 months) Curcuma longa in the form of encapsulated powder, dry vegetable extract, vegetable tincture or other pharmaceutical presentation; recent use (6 months) of plant-derived antioxidant supplements or multivitamins and minerals; volunteers using medications that alter coagulation characteristics such as antiplatelet agents, anticoagulants, low molecular weight heparin and thrombolytic agents; individuals with gallstones or biliary tract obstruction; carriers of autoimmune diseases; inflammatory diseases; infectious diseases; chronic kidney disease; gastric ulcers; liver diseases; cancer; acquired immunodeficiency syndrome	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-9xtq9p6	CuidAR: reducing hospitalizations and costs with Asthma in Brazil	Not yet recruiting	Intervention	2023-01-16	<NULL>	<NULL>	5827	CuidAR: reducing morbidity and costs in Asthma in the country	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-15	Associação Hospitalar Moinhos de Vento	Associação Hospitalar Moinhos de Vento	https://ensaiosclinicos.gov.br/rg/RBR-9xtq9p6	<NULL>	Participants of both sexes, aged between ≥6 and ≤65 years at the time of study entry; Medical diagnosis of asthma; Asthma Control Test or Childhood Asthma Control Test with a score &lt; 20; Previous history of two or more episodes of exacerbation; use of bronchodilators and systemic corticosteroids in the last 12 months; Possibility of access by the study team through the patient&apos;s personal phone and/or guardians; Patient followed up for at least 3 months in the basic health unit.	Absence of consent to participate in the study by the guardian and/or participant; Patients diagnosed with chronic obstructive pulmonary disease, defined as dyspnea accompanied by chronic cough with or without sputum, recurrent respiratory infections and spirometry with an forced expiratory volume in one second/forced vital capacity index &lt;0.7 after bronchodilator administration; Major smoking history (&gt; 20 years of smoking or &gt; 10 packs/year); Pregnant women, breastfeeding and/or planned pregnancy during the study period; Hospitalization for asthma in the last 30 days; Cognitive impairment and other conditions that may affect asthma treatment or study adherence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-4pfcg78	Unilateral deep brain stimulation for the treatment of drug-refractory simple partial epilepsy	Recruiting	Intervention	2023-01-15	<NULL>	<NULL>	5824	Unilateral thalamic specific nuclei deep brain stimulation for the treatment of refractory focal epilepsy	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-08	Hospital das Clínicas, Faculdade de Medicina, Universidade Federal de Goiás	Instituto Neurológico de Goiânia	https://ensaiosclinicos.gov.br/rg/RBR-4pfcg78	<NULL>	Volunteers with focal motor epilepsy, sensitive, with auditory and visual symptomatology refractory to conservative treatment; age 18 to 60 years; Brazilian; with structural lesion identified by the MRI, entering primary, somesthetic, visual or auditory motor area, without other lesions.	Volunteers with focal epilepsy combined with other types of epilepsy; with comorbidities that make the surgical procedure high risk; active infections; uncontrolled systemic arterial hypertension; uncontrolled blood dyscrasias; use of antiplatelet or anticoagulant drugs which temporary suspension is impracticable due to potential risks; impossibility to attend follow up appointments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-6cvpj4g	Papain associated with root planning in treatment of Periodontitis	Recruiting	Intervention	2023-01-14	<NULL>	<NULL>	5821	Papain with the treatment of inflammatory diseases that occur around the teeth	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-25	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6cvpj4g	<NULL>	Patients with chronic periodontitis with at least 4 periodontal pockets in the test hemiarch(s) and in the control hemiarch(s), equal to or greater than 4mm;  presence of at least 7 teeth in each type of region treated	Patients who had not undergone periodontal treatment for at least 6 months before the start of the experiment; patients who had not taken anti-inflammatory or antibiotics for at least 2 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-10vc6r63	Study of the effectiveness of hemoderivates	Recruiting	Intervention	2023-01-14	<NULL>	<NULL>	5822	Study of the effectiveness of blood products in alveolar repair	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Éwerton Daniel Rocha Rodrigues	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10vc6r63	<NULL>	Age between 18 to 50 years; no systemic disease; not use medications that interfere with the procedure on the day or week prior to the research; present a surgical site with no current signs and symptoms of infection; present mandibular third molars in similar positions and with indication for extraction	History of pregnancy or lactation; with a history of allergy to any drug used in the experiment and not participating in all phases of the proposed research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-3p9h7dy	Treatment effects of Anterior Open Bite and Maxillary Deficiency	Recruiting	Intervention	2023-01-14	<NULL>	<NULL>	5823	Evaluation of Anterior Open Bite and Maxillary Transverse Discrepancy treatment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-12	Centro Universitário Ingá - UNINGA	Faculdade De Ensino  Superior de Chapecó (FACESC)	https://ensaiosclinicos.gov.br/rg/RBR-3p9h7dy	<NULL>	Schoolchildren aged 7 through10 years old; systemically healthy; at the end of the first transitional period or in the intransient period of occlusion development according to the Van der Linden classification; with the maxillary first permanent molars fully erupted; patients with anterior open bite equal to or greater than 1 mm; transverse maxillary deficiency of at least 3 millimeters; etiology of anterior open bite caused by non-nutritive habits and/or atypical swallowing; prepubertal stage of vertebral maturation (cs1 or cs2 stages); agreement of parents or guardians and children to participate in the study by signing written informed consent.	Children with craniofacial anomalies, hyperdivergent facial pattern, congenital absence of any permanent tooth, with severe crowding, with complete deciduous or permanent dentition, with structural alterations in the anchor teeth (e.g. enamel hypoplasia, amelogenesis or dentinogenesis imperfecta), in speech therapy, children with a history of behavioral problems or uncooperative patients, children previously diagnosed as mouth breathers in treatment or who have already undergone previous orthodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-98nzfnq	Effects of Lower Limb Resistance Training with different planning models on Strength and Lean Mass of military personnel	Data analysis completed	Intervention	2023-01-13	<NULL>	<NULL>	5818	Comparison between the effects of Periodized Strength Training Programs, Machine versus Free Weight, on parameters of neuromuscular fitness in Brazilian Army militaries	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Instituto de Pesquisa da Capacitação Física do Exército - IPCFEx	Escola de Educação Física e Desportos da Universidade Federal do Rio de Janeiro - EEFD/UFRJ	https://ensaiosclinicos.gov.br/rg/RBR-98nzfnq	<NULL>	have answered negatively to all the sentences of the Physical Activity Readiness Questionnaire (PARQ); be a member of the Brazilian Army;  be between 18 and 26 years old; not having had any type of musculoskeletal injury for at least the last six months; male individuals	not being able to fully implement the predicted protocols; not being able to participate in the intervention due to medical recommendations; missing 3 (three) training sessions; make use of medications and/or supplements that may interfere with the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-59nksfr	Treatment of Dental Sensitivity associated with changes in Tooth Enamel Formation	Recruiting	Intervention	2023-01-13	<NULL>	<NULL>	5820	Treatment of Dental Hypersensitivity associated to Molar Incisor Hypomineralization	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Programa de Pós Graduação em Odontologia da Universidade Federal do Paraná	Programa de Pós Graduação em Odontologia da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-59nksfr	<NULL>	Health children. Both gender. 8 years of age. With permanent incisor or permanent first molars affected by molar incisor hypomineralization and dental hipersensitivity	Children with teeth decay associated to molar incisor hypomineralization and dental fluorosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-2qm8jrp	Laser for pain relief in Nipple and Perineal Trauma in postpartum	Recruiting	Intervention	2023-01-13	<NULL>	<NULL>	6520	Photobiomodulation therapy in Nipple and Perineal Trauma in the puerperal period: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Centro de Atenção Integral à Saúde da Mulher	Centro de Atenção Integral à Saúde da Mulher	https://ensaiosclinicos.gov.br/rg/RBR-2qm8jrp	<NULL>	"Inclusion criteria for the Nipple Trauma group: Older than 18 years; Who are breastfeeding and have nipple trauma; Present understanding of the Portuguese language and cognitive ability to consent; Reporting nipple pain of at least 4 (four) on the visual analogue scale (VAS) at the time of approach.

Inclusion criteria for the Perineal Trauma group: Older than 18 years; Who have perineal injuries resulting from childbirth (episiotomy or 2nd-degree laceration, at least); Reporting perineal pain of at least 4 (four) on the visual analogue scale (VAS) at the time of the approach; Present understanding of the Portuguese language and cognitive ability to consent."	"Exclusion criteria for the Nipple Trauma group: Mastitis or neoplasm; Photosensitivity to exposure to sunlight; Breast malformation, breast implant, or breast reduction surgery.
Exclusion criteria for the Perineal Trauma group: Active gynecological infections; Unresolved puerperal hemorrhage."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-5q2w7zt	Evaluation of Laser Snoring Treatment	Data analysis completed	Intervention	2023-01-13	<NULL>	<NULL>	7687	Clinical Evaluation of the Use of Er:YAG Laser in Snoring Disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-28	Faculdade de Odontologia da Universidade de São Paulo	Instituto de Pesquisas Energéticas e Nucleares - IPEN	https://ensaiosclinicos.gov.br/rg/RBR-5q2w7zt	<NULL>	Patients who present a clinical picture compatible with primary snoring; mild or moderate obstructive sleep apnea with polysomnography (of any type); age group from 25 to 65 years; both sexes and regardless of color or social class; agreement and signing the free informed consent term	Have significant physical obstruction of the nostrils and/or throat observed by the physician with strict indication of surgery and those with laryngeal obstruction; having previously performed surgery in the oropharynx region; patients using more than two antihypertensive drugs or with a previous diagnosis of heart problems; patients using photosensitive medication; presence of lesion in the oropharynx; history of alcohol and/or drug abuse; smoking patients; patients with untreated neurological or psychiatric disorders; patients with craniofacial malformations; pregnant or lactating patients; patients with a BMI above 40kg/m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:29
RBR-4kryg4s	Effectiveness of an Internet-Delivered Physical Exercise Program in pain and physical function of women with knee Osteoarthritis	Recruitment completed	Intervention	2023-01-12	<NULL>	<NULL>	5814	Effectiveness of an Internet-delivered Physical Exercise Program in pain and physical function of women with clinical diagnosis of knee Osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-4kryg4s	<NULL>	Women aged 50 years or older; Dwelling in Diamantina; Clinical diagnosis of knee osteoarthritis (uni or bilateral); Stable clinical condition in the last three months; Mild to moderate pain in the knee(s) (score &gt; 1 and ≤ 7 on the numerical pain scale	Other health conditions that prevent the evaluation or the performance of the physical exercise program (internet-delivered), such as visual and/or hearing deficit, neurological or psychiatric diseases, pulmonary or cardiac diseases, musculoskeletal limitations; Cognitive deficit assessed through the Mini-Mental State Examination; Being in physiotherapeutic treatment for knee OA; Be performing some physical exercise program; History of recent hospitalization due to cardiovascular or cerebrovascular events; Presence of knee prosthesis; Not having access to the WhatsApp Web application	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-497mxmm	Effects of Physical Training on the heart and nervous system of patients attending a cardiac rehabilitation program	Recruiting	Intervention	2023-01-12	<NULL>	<NULL>	5815	Effects of Physical Training on hemodynamic and autonomic responses to Muscle Ergoreflex Activation in patients attending a cardiac rehabilitation program	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-497mxmm	<NULL>	Be aged between 40-70 years. For the groups composed of people with cardiovascular impairment: be enrolled in the cardiac rehabilitation service of Hospital Universitário Pedro Hernesto (HUPE)	For groups composed of people with cardiovascular impairment: practice of regular physical exercises (≥ 3 days/week for 30 min) in the last 6 months; malnutrition; use of antidepressant medication; smoking habit. In addition to the aforementioned criteria, for healthy control subjects, those with a previous or current diagnosis of arterial hypertension; coronary artery disease; heart failure; ischemic disease; pulmonary disease; diabetes mellitus; Chagas disease; tuberculosis; and/or use of antihypertensive medication ill not be considered eligible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-6dctww5	Movement research project: effects on movement after Physical Therapy in children with Cerebral Palsy after application of Botulinum Toxin type A	Not yet recruiting	Intervention	2023-01-12	<NULL>	<NULL>	5816	Kinesis research project: effects on motor performance after Physiotherapy Care in children with Cerebral Palsy after application of Botulinum Toxin type A	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-30	Hospital Universitário Bettina Ferro de Souza	Hospital Universitário Bettina Ferro de Souza	https://ensaiosclinicos.gov.br/rg/RBR-6dctww5	<NULL>	Affected with diparetic or spastic hemiparetic cerebral palsy; age between 4 and 14 years; both genders; be able to walk independently in a closed environment (Gross Motor Function Classification System [GMFCS] from I to III; able to perform all assessment and treatment procedures in the study	Presence of joint blockage in the joints of the lower limbs; previous orthopedic surgery in the lower limbs up to one year prior to selection; presence of visual impairment; important cognitive alterations that prevent the accomplishment of the study protocols; abandonment of physical therapy; presence of fixed contracture in the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-9ws5yfx	Effectiveness of the Mindfulness-based Health Promotion Program (MBHP) to improve the psychological well-being of university students: a study controlled and randomized	Recruitment completed	Intervention	2023-01-12	<NULL>	<NULL>	5817	Effectiveness of the Mindfulness-based Health Promotion Program (MBHP) to improve the psychological well-being of university students: a study controlled and randomized	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9ws5yfx	<NULL>	Healthy volunteers; undergraduate students at the Federal University of São Paulo (UNIFESP); campus São Paulo age greater than or equal to 16 years	Volunteers with acute mental disorders; age less than 16 years on the date of signature of the TCLE; previous pregnancy within six months or current; and regular practitioners of mindfulness, meditation, yoga	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-5fntkyv	Evaluation of color change in Ceramic Laminate procedures - Clinical Trial	Recruitment completed	Intervention	2023-01-12	<NULL>	<NULL>	7633	Evaluation of color change after application of an Adhesive on the inside of Ceramic Laminates - Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-04	Universidade de São Paulo - Faculdade de Odontologia	Dentscare LTDA	https://ensaiosclinicos.gov.br/rg/RBR-5fntkyv	<NULL>	Individuals of both sexes; aged between 18 and 60 years; good general and oral health; absence of orthodontic appliances; absence of joint problems; absence of gingival recession on the buccal surface; absence of mandibular prognathism or maxillary retrognathism; willing to undergo radiographic examinations; and be willing to sign an informed consent.	Smokers; individuals with large restorations in the anterior region; dark colored teeth (VITA A3.5 and C4 shades); teeth with fluorosis; patients with gingivitis and/or periodontal diseases; teeth with severe gingival bleeding; poor oral hygiene; high rates of caries; history of allergy to any of the materials; pregnancy; use of medications known to interfere with the oral environment; systemic or malignancies; inability to undergo any study-specific techniques; lack of adequate vertical dimension of occlusion (OVD); lack of space for correct installation of laminates; and presence of parafunctional habits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:27
RBR-7qmdrhy	Influence of Dextroketamine on Brain Electrical Activity Monitoring during Total Venous Anesthesia	Recruitment completed	Intervention	2023-01-11	<NULL>	<NULL>	5812	Influence of Dextroketamine on Electroencephalogram during Total Venous Anesthesia	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-15	Hospital São Carlos	Hospital São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-7qmdrhy	<NULL>	patients both genders; undergoing elective operations under general anesthesia; physical status P1 (American Society of Anesthesiologists); ages between 20 and 45 years and; body mass indexes between 21 and 26 kg.m-2	Patients with neurological disease; recent use of drugs that may alter the electroencephalogram.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-95qzc2s	Effect of Ozonated Water on Bad Breath and Clinical Parameters in Patients with Periodontitis	Recruiting	Intervention	2023-01-10	<NULL>	<NULL>	5808	Effect of Ozonized Water on Halitosis and clinical parameters of patients with Periodontal Disease: A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Faculdade de Odontologia da Universidade de Passo Fundo	Faculdade de Odontologia da Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-95qzc2s	<NULL>	Complaint of halitosis in the presence of periodontal disease; over 18 years of age; moderate to severe generalized periodontitis	Illiteracy; halitosis only by tongue coating; non-oral halitosis; acute oral lesions or necrotizing ulcerative periodontitis; use of antibiotics in the last 90 days; pregnancy or breastfeeding; decompensated systemic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-2cxwvcy	The effect of Manual Release on Abdominal Scars in patients with Low Back Pain for a Long Time	Recruitment completed	Intervention	2023-01-10	<NULL>	<NULL>	5809	The effect of Manual Release on Abdominal Scars in patients with Chronic Nonspecific Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	CBO - Colégio Brasileiro de Osteopatia	CBO - Colégio Brasileiro de Osteopatia	https://ensaiosclinicos.gov.br/rg/RBR-2cxwvcy	<NULL>	Age above or equal to 18 years; both genders; abdominal surgery between umbilicus and pubic symphysis; Sensitivity to palpation at any of the vertebral levels from L1 to S3; chronic low back pain	Volunteers diagnosed with a rheumatic disease; Drug history; Excessive drug use; Low back pain less than 3 months old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-98v2y84	Effectiveness of technology&apos;s use for the management and control of type 2 Diabetes Mellitus. Study in a population residing in Complexo do Alemão, Rio de Janeiro	Data analysis completed	Intervention	2023-01-10	<NULL>	<NULL>	5810	Effectiveness of an Educational System and Remote Data Collection of patient information by Mobile Devices and the Internet in the metabolic control of type 2 Diabetes Mellitus A controlled study in a population residing in Complexo do Alemão, Rio de Janeiro	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-04-05	Hospital Universitário Pedro Ernesto	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-98v2y84	<NULL>	The study selected participants with a previous diagnosis of type 2 diabetes according to the American Diabetes Association criteria. Adults aged between 18 and 75 years; with a previous diagnosis of type 2 diabetes or fasting blood glucose &gt;126 mg/dL and/or random blood glucose &gt;200 mg/dL; under non-pharmacological treatment; oral antihyperglycemic agents or insulin use were included. All the participants received free internet access during the study. Thus, it was considered inclusion criteria to live in areas with available cabling for the establishment of an internet connection, which was provided by the study group	Patients with type 1 diabetes; other types of diabetes; and pregnant women were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-9zn76ph	Effectiveness of ice pack and hot pack on the snakebite site	Recruiting	Intervention	2023-01-10	<NULL>	<NULL>	5811	Effectiveness of intervention at the site of botropic poisoning by means of ice and hot compresses: open randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-07	Universidade do Estado do Amazonas	Fundação de Medicina Tropical Dr. Heitor Vieira Dourado	https://ensaiosclinicos.gov.br/rg/RBR-9zn76ph	<NULL>	Patients of both sexes with Bothropic snake envenomation within a maximum of 24 hours of evolution; age greater than 18 years	Patient with bleeding with systemic and local repercussions at the time of recruitment; patients who used ice or hot packs before arriving at the hospital	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-949wrsh	Study comparing two treatments with Laser for Lower Limb Microvarices	Recruitment completed	Intervention	2023-01-09	<NULL>	<NULL>	5805	Transdermal Laser Association comparing two treatments of Sclerotherapy for the Treatment of Unesthetic Veins of Lower Limbs: Triple Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-10	Clinica Prime Vascular	Clinica Prime Vascular	https://ensaiosclinicos.gov.br/rg/RBR-949wrsh	<NULL>	Volunteers women; aged between 18 and 70 years; reticular veins and telangiectasias; without reflux of the deep venous or saphenous system; Fitzpatrick Skin Type I, II or III; Patients should have at least one reticular vein with a minimum length of 5 cm in one of the lower limbs on the lateral side of the thigh.	Venous disease CEAP class greater than C1; who underwent procedure with sclerotherapy or transdermal laser in the last 12 months; skin classification Fitzpatrick IV, V or VI; pregnancy or puerperium; known allergy; peripheral arterial disease; diabetes; dermatitis at the treatment site; asthma; migraine; deep or superficial deep vein thrombosis (DVT); family history of DVT; known thrombophilia or any hypercoagulable state and use of anticoagulants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-97vs4tt	Effect of Exercises with Partial Blood Flow Restriction on muscular and functional aspects of individuals with difference in muscle strength between lower limbs	Not yet recruiting	Intervention	2023-01-09	<NULL>	<NULL>	5806	Effects of Partial Vascular Occlusion on muscular and functional aspects of individuals with Strength Asymmetry in Lower Limbs	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-97vs4tt	<NULL>	Participants must be between 18 and 59 years old; presence of muscle imbalance, identified by a difference greater than or equal to 10% in muscle strength between the lower limbs and/or presenting values within the upper quartile among all those evaluated, if difference greater than or equal to 5% and medical clearance to perform the test training, provided by the physician associated with the study (Dr. Francisco Wekerlin Morozowski)	Participants will be excluded from the research if they present alterations that make it impossible to complete the questionnaires or understand the guidelines and carry out the tests; systolic blood pressure greater than or equal to 140 mmHg or diastolic blood pressure greater than or equal to 90 mmHg; cannot have more than one risk factor for thromboembolism, which includes: (1) body mass index greater than or equal to 30 kg.m-2; (2) diagnosis of chronic inflammatory disease; (3) history of pelvic, hip, and femur fractures; (4) major surgeries in the last 6 months; (5) diagnosis of varicose veins in the last 6 months; (6) family history of deep vein thrombosis and pulmonary embolism; (7) use of oral contraceptive methods; or (8) tobacco use	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-8z7295b	Effect of execution order of Weight Training and Walking on blood sugar levels in postmenopausal women with type 2 diabetes	Recruiting	Intervention	2023-01-09	<NULL>	<NULL>	5807	Effect of execution order Concurrent Physical Exercise on glycemic acute and subacute response in postmenopausal women with type 2 Diabetes Mellitus	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-31	Programa de Pós-Graduação em Ciências da Saúde	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8z7295b	<NULL>	Postmenopausal women; aged between 45 and 60 years; with the diagnosis of Type 2 Diabetes Mellitus; who presents a medical certificate that allows the patient to practice physical exercise	Making use of hormone therapy; making use of exogenous insulin; being obese (≤30 kg/m2); having complications related to Diabetes; smokers; presenting physical limitations or any pathology that prevents and/or compromises the performance of the physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-729kr8x	Mixing donor milk with expressed breast milk in premature newborns as a health promotion strategy.	Recruiting	Intervention	2023-01-06	<NULL>	<NULL>	5803	"Causes and effects of maternal microbiota at birth and newborn survival
preterm infants: maternal and child health promotion strategies"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-03	Universidade Federal de Santa Catarina	Maternidade Carmela Dutra	https://ensaiosclinicos.gov.br/rg/RBR-729kr8x	<NULL>	Newborns less than or equal to 32 weeks born in the Maternity Carmela Dutra - Florianópolis - Santa  Catarina  will be included	Newborns with congenital malformations will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-2nbmpbc	Angiotensin- (1-7) supplementation in physical exercise practitioners	Recruitment completed	Intervention	2023-01-06	<NULL>	<NULL>	5804	Angiotensin- (1-7) as a new ergogenic supplement for exercise practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-20	Laboratório de Fisiologia do Exercício	Universidade Federal de Ouro Preto	https://ensaiosclinicos.gov.br/rg/RBR-2nbmpbc	<NULL>	Athletes and practitioners of physical exercise; older than 18 years; involved in their training programs for at least one year; have participated in competition in the last six months at the regional level	Present some type of illness that compromises data collection; individuals with any type of pathology; smokers; make use of medications such as anti-inflammatories and antibiotics and / or others that may compromise research data; as well as supplements that interfere with cardiovascular parameters such as caffeine and guarana	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-6ms6sns	Is the esthetic effect of Botox influenced by physical exercise	Terminated	Intervention	2023-01-05	<NULL>	<NULL>	5800	Durability of the aesthetic applications of Botulinum Toxin type A in practitioners of high intensity physical exercise	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2022-08-01	Centro Universitário Ingá - UNINGÁ	Centro Universitário Ingá - UNINGÁ	https://ensaiosclinicos.gov.br/rg/RBR-6ms6sns	<NULL>	Volunteers with complain of dynamic wrinkles; moderate or severe dynamic forehead and glabellar lines according to the Merz 5-point scale; never received botulinum toxin type A injections in any area of the face.	Volunteers that received Antitetanic vaccination and any chemical peel in the past 6 months; no esthetics procedures that could affect forehead and glabellar regions in the previous 12 months; with autoimmune disease; current use of drugs that act at neuromuscular junctions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-9n4sn5m	Effects of 12-hour overnight fasting on metabolism and quality of life in overweight middle-aged women	Data analysis completed	Intervention	2023-01-05	<NULL>	<NULL>	5801	Metabolic responses of overweight/obesity climacteric women according to feeding times	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Centro de ciências da saúde - Universidade Federal de Pernambuco - UFPE	Centro de ciências da saúde - Universidade Federal de Pernambuco - UFPE	https://ensaiosclinicos.gov.br/rg/RBR-9n4sn5m	<NULL>	Female individuals; aged between 40 and 59 years; body mass index (BMI) between 25 kg/m2 and 39.9 kg/m2; waist circumference above 88 centimeters	Women with previous diagnosis of changes in the thyroid gland; impaired liver function; impaired kidney function; cardiovascular diseases; cancer; serious illness; using medication that alters weight; diagnosed with psychiatric illnesses. In addition, they will also be deleted; gastrointestinal problems; using drugs that may interfere with body composition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-5398927	Effect of online brief intervention to reduce alcohol use during the COVID-19 pandemic: a non-randomized clinical trial	Data analysis completed	Intervention	2023-01-05	<NULL>	<NULL>	5802	Feasibility and effectiveness of brief online interventions to reduce alcohol use among youth and adults during the COVID-19 pandemic: a randomized clinical trial	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2020-08-05	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5398927	<NULL>	Be 18 years of age or older; both sexes; and agree to participate in all stages of the research	Pregnant women; people with difficulty accessing the internet or mobile phone; incomplete questionnaires; and participants in the pilot study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-7znwrjm	Effects of Handgrip Training on blood pressure variability and cardiac autonomic modulation in hypertensive patients	Recruiting	Intervention	2023-01-03	<NULL>	<NULL>	5798	Effects of Isometric Handgrip Training on blood pressure variability and cardiac autonomic modulation in Hypertensive patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-16	Faculdade de Educação Física, Universidade Federal do Amazonas	Faculdade de Educação Física, Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-7znwrjm	<NULL>	Both sexes, over 18 years old;diagnosis of Hypertension limited to stage II; not have high cardiovascular risk; not participating in a physical exercise program for at least six months prior to the start of the study	Adherence less than 85% of training sessions; diagnosis of other cardiovascular diseases or diabetes during the course of the study; adherence to another supervised exercise program during the study; change in medication class and/or dose during the study; disease worsening (Stage III SAH, ≥180 and ≥110 mmHg, systolic and diastolic blood pressure, respectively)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-67xwg78	Comparison of the effect of Suprascapular Nerve Block associated with Physiotherapy and Physiotherapy alone in the treatment of frozen shoulder	Withdrawn	Intervention	2023-01-02	<NULL>	<NULL>	5795	Comparison of the effectiveness of Suprascapular nerve block associated with Physical therapy and Physical therapy alone in the treatment of Primary rigid shoulder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-13	Clínica de  Fraturas	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-67xwg78	<NULL>	Patients with a painful shoulder of spontaneous onset; accompanied by progressive limitation of glenohumeral movement in all directions; including at least 50% reduction in external rotation; not subjected to previous treatment; and confirmation by magnetic resonance imaging characterized by hypersignal of the inferior joint capsule greater than 4 mm; decreased filling of the axillary recess and edema in the rotator interval; age between 20 and 60 years.	Secondary rigid shoulder; patients already treated for rigid shoulder prior to the study; absence of magnetic resonance to confirm the diagnosis; patients with type I diabetes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-6v5cvhj	Family constellation and chronic pelvic pain	Not yet recruiting	Intervention	2023-01-02	<NULL>	<NULL>	5796	The effect of Family constellation on quality of life, anxiety, depression, resilience and pain intensity in women with chronic pelvic pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-23	Hospital das Clínicas da Universidade Federal de Goiás	Hospital das Clínicas da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6v5cvhj	<NULL>	Age ≥ 18 years; women with lower abdominal pain starting at least six months ago, not exclusively cyclical or related to intercourse	History of pregnancy in the last 12 months; suspected or confirmed current pregnancy; history of treatment for malignant neoplasm, with the exception of non-melanoma skin cancer; history of surgery in the last three months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-2m6qx2r	Effect of chemotherapy on muscle tissue membrane integrity measured by phase angle in women with breast cancer	Recruitment completed	Observational	2023-01-02	<NULL>	<NULL>	5797	Effect of chemotherapy on anthropometric indicators, physical activity level, cardiovascular parameters in women with breast cancer	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-01-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-2m6qx2r	<NULL>	Age over 18 years, diagnosis of breast cancer, neoadjuvant or adjuvant chemotherapy in their therapeutic protocol.	Participants with a previous diagnosis of chronic obstructive pulmonary disease, heart failure, or infectious diseases were excluded from the study. Additionally, volunteers who did not complete the assessment protocol, were unable to return for reassessment or did not carry out the therapeutic protocol prescribed during chemotherapy were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-29sg4xg	Evaluation of Growth Hormone Treatment in adolescence: Effect on body composition, bones, glucose and lipids in patients who were treated with this hormone	Recruitment completed	Intervention	2022-12-30	<NULL>	<NULL>	5789	Evaluation of GH Growth Hormone (rhGH) Treatment in the transition phase: Impact on body composition, bone metabolism, glucose and lipids in patients who were treated with rhGH	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2017-05-17	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-29sg4xg	<NULL>	both gender; 14 to 20 years of age; growth speed less than 2 cm/year; bone age equal to or greater than 15 years in girls and 16 years in boys; somatropin use for 3 consecutive years	chronic renal failure; type 1 diabetes mellitus; osteopathies; Prader Willi syndrome; chronic use of corticosteroids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-8xdc8yz	Use of Olaparib, a drug that inhibits an enzyme linked to inflammatory response and DNA repair, in sepsis	Not yet recruiting	Intervention	2022-12-30	<NULL>	<NULL>	5790	Randomized clinical trial to evaluate the safety and pharmacodynamics of the PARP inhibitor Olaparib in sepsis	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2023-02-01	Escola Paulista de Medicina, Universidade Federal de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8xdc8yz	<NULL>	Male patients diagnosed with septic shock for less than 24 hours; signing of free and informed consent form	Female patients (women) because women&apos;s hormones can alter the effects of olaparib; patients unable to use medication by mouth or by tube; patients with AIDS; patients using immunosuppressive therapy, that is, which compromises the body&apos;s defenses; patients using corticosteroids; patients with cancer or undergoing chemotherapy; chemotherapy performed up to 30 days; patients who had cardiac arrest; patients with recent acute infarction or problems with the coronary artery, the artery that supplies the heart; liver disease, such as liver cirrhosis; very severe patients, with the prospect of death within 24 hours; palliative or end-of-life care; patients using treatments that may have their effects altered or alter the effects of olaparib (examples: itraconazole, fluconazole, verapamil, rifampicin, phenytoin, carbamazepine, phenobarbital and modafinil; Saint John&apos;s herb)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-9b7jbxm	"Randomized, pilot, multicenter clinical study in Brazil to assess the feasibility of
Improvement of static lung compliance by different Positive End Expiratory Pulmonary Pressure titration methods in patients with Adult Respiratory Distress Syndrome"	Terminated	Intervention	2022-12-30	<NULL>	<NULL>	5791	"Randomized, pilot, multicenter clinical study in Brazil to assess the feasibility of
improvement of static lung compliance by different PEEP Titration Methods in patients with ARDS"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-28	Hospital Nereu Ramos	Hospital Nereu Ramos	https://ensaiosclinicos.gov.br/rg/RBR-9b7jbxm	<NULL>	Intubated patients of both gender with mechanical ventilation; ARDS Berlin Criteria with less than 72 hours; older than 18 years old	High dose of vasoactive drugs; Intracranial hypertension; Patients with acute myocardial infarction; Presence of pneumothorax, subcutaneous emphysema, pneumomediastinum, or pneumatocele; Paliative care exclusive patients; Severe thoracic trauma and/or thorax drainage; Patients with pacemaker or automatic desfibrilators	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-2y6fv92	Assessment of muscle electrical activity during Cardiopulmonary Testing	Recruitment completed	Observational	2022-12-30	<NULL>	<NULL>	5792	Electromyographic evaluation during Cardiopulmonary Exercise Test: retrospective study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-01	Centro Universitário da Paraíba (UNIESP)	Centro Universitário da Paraíba (UNIESP)	https://ensaiosclinicos.gov.br/rg/RBR-2y6fv92	<NULL>	The inclusion criteria for the research will be obese subjects with any of the three different degrees of obesity (body mass index-BMI above 30kg/m2); normal weight individuals and individuals with a previous clinical diagnosis of lung disease (obstructive pulmonary disease and/or restrictive disease) of both genders; aged 18 years or over; active or sedentary; with no change in the locomotor system and/or change in balance detected in an initial examination carried out in a routine evaluation from June to December 2021 at the Clinic Clinic	Subjects who may have had their data analyzed/evaluated in a database and incorrectly tabulated in an Excel spreadsheet; who have gaps in the tabulation of anthropometric variables and/or cardiopulmonary exercise test (CPET) and electromyography (EMG) variables; who had a test of cardiopulmonary effort with less than the recommended time for data evaluation (time less than 8 minutes) or those with signal failure of the EMG tracing during the test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-104rzp5y	Evaluation of enamel polishing techniques after orthodontic brackets removal	Recruitment completed	Intervention	2022-12-30	<NULL>	<NULL>	5793	Longitudinal evaluation of the dental enamel surface after the removal of orthodontic brackets. Effects of surface treatments and analysis times	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-07-01	Faculdade de Odontologia de Araçatuba - UNESP	Faculdade de Odontologia de Araçatuba - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-104rzp5y	<NULL>	"Proper oral hygiene	; Proper systemic health; Healthy soft tissues; Presence of scratches on upper central incisors; Resin residue, if any, must be present on both central incisors; Available to attend the department; Volunteers of both genders; age between 18 and 25 years"	"Caries lesions and restorations on anterior teeth; Fractured restorations on posterior teeth; Periodontal disease; Regular use of alcohol/ smokers; Fixes or removables prothesis; Systemic disease;	Pregnant or breastfeeding volunteers; Dental enamel with stain of any etiology"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-3bf8q5z	Effects of lowerlimb Strengthening in athletes with Achilles Tendon Pain	Recruiting	Intervention	2022-12-30	<NULL>	<NULL>	5794	Effects of multi-joint lowerlimb Strengthening in recreational athletes with Achilles Tendinopathy: a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Minas Gerais	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-3bf8q5z	<NULL>	Volunteers of both genders; aged between 18 and 45 years old; with clinical diagnosis of achilles tendinopathy (insertional or mid-portion); enrolled in sports activities and tasks that load the achilles tendon (e.g.  jump, running); having presence of achilles tendon pain for at least three months.	Subject with history of lowerlimb surgery; history of lowerlimb injury in the past six months; have done corticosteroids infiltration in the past six months; have used Fluoroquinolones in the past 12 months; clinical diagnosis of diabetes, obesity, familial hypercholesterolemia  or any other systemic disease that impairs the performance of physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-66pyrh8	Evaluation after third molar Extraction and Laser Therapy	Recruiting	Intervention	2022-12-29	<NULL>	<NULL>	5785	Clinical and Thermographic evaluationof third molar sockets after Extraction that received Laser Therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-66pyrh8	<NULL>	Volunteers both sexes; who present the two lower third molars included or semi-impacted, with indication for extraction and who radiographically present in similar positions; Volunteers who accept to participate in the research and who sign an Informed Consent Form	Volunteers with acute pericoronitis; infections and pathologies associated with third molars; periodontal disease; patients on chronic use of corticosteroids; who have previous neuralgias or myofascial disorders; who are undergoing dermatological treatment on the face; who have decompensated systemic conditions, such as diabetes and blood dyscrasias; smokers; allergic to the drugs selected for the research; pregnant women; lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-10vtd55m	Assessment of pain caused by respiratory therapy in children after heart surgery	Data analysis completed	Intervention	2022-12-29	<NULL>	<NULL>	5786	Assessment of pain caused by respiratory therapy in children with congenital heart disease after surgery	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-01-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10vtd55m	<NULL>	Children with congenital heart disease; both genders; age between 0 and 18 years; undergoing heart surgery	Parental request; intraoperative death; hemodynamic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-4d8jr7s	Health Technology Tools for safe Dysphagia care: a randomized clinical trial	Not yet recruiting	Intervention	2022-12-29	<NULL>	<NULL>	5787	Health Technology Tools for safe Dysphagia care: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-17	Universidade Federal do Rio Grande do Norte - UFRN	Universidade Federal do Rio Grande do Norte - UFRN	https://ensaiosclinicos.gov.br/rg/RBR-4d8jr7s	<NULL>	be an adult (age ≥ 18 years and &lt; 60 years);present risk of dysphagia verified when meeting two or more criteria according to Felix et al (2017) and later confirmed by swallowing videoendoscopy (VED);those who confirm voluntary participation in the study by signing the Free and Informed Consent Term (FICT).	Participants who have an intellectual condition that makes it impossible for them to participate and/or understand the stages of the research; Participants diagnosed with severe dysphagia after VED will also be excluded considering the risk of maintaining oral feeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-7fqxkpp	Effects of an Application on the Knowledge of nursing students interventions	Not yet recruiting	Intervention	2022-12-28	<NULL>	<NULL>	5782	The effectiveness of using a Mobile Application in the knowledge of nursing students about the Health of the Elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Faculdade de Ceilândia da Universidade de Brasília	Fundação Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-7fqxkpp	<NULL>	Being a student regularly enrolled in the nursing course; being in the 9th or 10th-degree semester; having a cell phone with internet to access the app; showing availability to participate in the research; being available to participate in the meetings.	Students who have any impediment (personal, emotional, and others) the use of the app; do not have a mobile device with the Android or IOS operating system; express unfamiliarity with digital technology; tahose who did not complete the research stages.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-5x7z9zf	Effects of acute administration of Modafinil on cognition and learning in the elderly	Recruiting	Intervention	2022-12-28	<NULL>	<NULL>	5783	Effects of acute modafinil administration on learning conditional relationships and emergence of stimulus equivalence in the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-15	Faculdade de Medicina de Ribeirão Preto	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5x7z9zf	<NULL>	Individuals 60 years of age or older; Be available to return for revaluations and have a telephone to contact	Presence of uncontrolled moderate to severe hypertension; Presence of cardiac arrhythmias, according to self-report; Hearing Loss; Use of Benzodiazepine; Use of cholinesterase inhibitors; medical diagnosis of Dementia, according to self-report	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-4mzcwpw	The extra benefit of using topical Clobetasol before Hydroquinone 4% in the treatment of Melasma	Not yet recruiting	Intervention	2022-12-28	<NULL>	<NULL>	5784	Topical Clobetasol as an adjunct treatment to 4% Hydroquinone in moderate to severe facial Melasma: a randomized, double-blind, controlled clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade Estadual Paulista (UNESP)	Universidade Estadual Paulista (UNESP)	https://ensaiosclinicos.gov.br/rg/RBR-4mzcwpw	<NULL>	Women; age between 18 and 60 years old; with moderate to severe facial melasma or mMasi greater than 5; without treatment for at least 45 days except of the using of sunscreen	Pregnant and lactating women; carriers of other concomitant facial dermatoses; dermatoses with photosensitivity; glaucoma; previous episode of perioral dermatitis; melasma with mMASI less than 5; history of hypersensitivity or local adverse reactions to the use of hydroquinone or clobetasol or any other component of the formulation described	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-4bzxqjj	Comparative study of labor induction with Foley Tube for 24 hours and 48 hours in pregnant women with previous cesarean section	Recruiting	Intervention	2022-12-27	<NULL>	<NULL>	5778	Intrauterine Foley Catheter for 24 hours versus 48 hours for cervical ripening in pregnant with one previous cesarean section: randomized trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-08	Guilherme Nicolau Camara	Universidade Estadual Paulista Julio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-4bzxqjj	<NULL>	One previous segmental cesarean section: medical recomendation for pregnancy interruption; Bishop score at 6 or least; single pregnancies with a term cephalic fetus	Premature rupture of membranes at the admission; non segmental previous uterine incision; suspicious fetal vitality; clinical suspicious for feto pelvic desproportion; patients that refuse to participate of the intervention; placenta pevia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-5tw3rrr	The effects of Osteopathic Treatment with specific techniques in patients with chronic non-specific back pain	Not yet recruiting	Intervention	2022-12-27	<NULL>	<NULL>	5780	The effects of specific Osteopathic Manipulative Treatment in patients with non-specific Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-26	Silvia de Lima Filó Lins	Clinica Reabilitar	https://ensaiosclinicos.gov.br/rg/RBR-5tw3rrr	<NULL>	Both sexes. Adults from 18 to 65 years old. Chronic non-specific low back pain for more than 3 months. With or without irradiation to the lower limb. Numerical rating scale of the same or greater than 2 in the last week. Score not greater than Roland Morris disability equal to 4.	Spinal canal stenosis, spine surgery or hip arthroplasty, recent trauma or fracture; infection, active cancer; reporting unexplained weight loss in the last month; pregnancy, breastfeeding or expecting to become pregnant in the next 3 months; neurological disorders such as cauda equina syndrome, spinal cord injury, alzheimer&apos;s, amyotrophic lateral sclerosis, multiple sclerosis, parkinson&apos;s, stroke; cardiorespiratory disorders, congestive heart failure, heart attack within the last 24 months, or any bleeding disorder; musculoskeletal disorders such as advanced osteoporosis, rheumatoid arthritis, avascular necrosis or osteonecrosis, osteoarthritis, use of narcotics or muscle relaxants during study enrollment, report having received any manual therapy intervention applied to the spine 30 days prior to the first study intervention, have a body mass index &gt; 35 kg/m2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-47ngbg3	Does Pain after Root Canal Treatment depend on the number of appointments?	Recruitment completed	Intervention	2022-12-27	<NULL>	<NULL>	5781	Incidence of Postoperative Pain in single and multiple session Endodontic Treatments: clinical study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Centro de Pesquisa da Universidade Positivo	Centro de Pesquisa da Universidade Positivo	https://ensaiosclinicos.gov.br/rg/RBR-47ngbg3	<NULL>	Both genders; older than 18 years; diagnosed with necrotic pulp; with normal physical and psychological health conditions; no use of analgesics and anti-inflammatories	Under 18 years old; vital pulp diagnosis; teeth with incomplete apex; pregnant; patients with non-odontogenic facial pain or chronic pain; patients who are taking analgesics and anti-inflammatories.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-5vw3vpg	Study comparing vaginal energy equipment	Not yet recruiting	Intervention	2022-12-26	<NULL>	<NULL>	5777	Laser and Radiofrequency treatment in women with Genitourinary Menopause Syndrome	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	Hospital da Mulher Prof. Dr. José Aristodemo Pinotti - CAISM	https://ensaiosclinicos.gov.br/rg/RBR-5vw3vpg	<NULL>	Post-menopausal women; genitourinary menopausal syndrome symptoms; vaginal dryness complaint	Vaginal estrogen use in the last 6 months; current or past 6 months use of systemic hormone replacement therapy; presence of stage III or IV pelvic organ prolapses; use of pacemaker; decompensated heart disease; cognitive deficit; peripheral or central neurological disorders; presence of any type of cancer or cervical dysplasia; hx of active urinary or vaginal infection; decompensated metabolic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-2cwq2pr	Comparison of the effectiveness of two local anesthetics in tooth extractions	Recruiting	Intervention	2022-12-23	<NULL>	<NULL>	5776	Comparison of the vestibular anesthetic effectiveness of lidocaine and articaine in upper third molar exodontics	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Éwerton Daniel Rocha Rodrigues	Faculdade de Odontologia da Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2cwq2pr	<NULL>	Age between 18 and 30 years; present surgical site without current signs and symptoms of infection; present maxillary third molars in similar positions and with indication for extraction.	history of pregnancy or lactation, with a history of allergy to any drug used in the experiment; who are using drugs that alter bone metabolism; do not participate in all phases of the proposed research; use medications that interfere with the procedure on the day or week prior to the research, such as antibiotics , corticosteroids and non-steroidal anti-inflammatory drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-106gykpj	The Effect of Hypopressive training improves Postpartum Belly, urine Loss and Abdominal Strength	Not yet recruiting	Intervention	2022-12-22	<NULL>	<NULL>	5774	The Effect of Hypopressive Exercises, original method, on improving Rectus Abdominal Diastasis, Adbominal Dysfunction and Pevic Floor Complaints in postpartum women: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-02	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-106gykpj	<NULL>	Will be included women aged 18 or over;  between 45 days and six months postpartum; with diagnosis of diastasis, considered as from 2 cm of distance at a point of the extension of the linea alba,  no history of previous abdominal aesthetic surgeries; do not have musculoskeletal disease that makes it impossible to perform the requested exercises.	Women who miss 20% of the intervention or do not show up for evaluation; women diagnosed with midline abdominal hernia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-8dvw5zp	Intervenções Farmacêuticas sobre o tratamento medicamentoso dos idosos com Doença de Risco Cardiovascular	Not yet recruiting	Intervention	2022-12-22	<NULL>	<NULL>	5775	Pharmaceutical Interventions on the Complexity of Pharmacotherapy in the elderly with Cardiovascular Risk Disease: a randomized controlled clinical trial with a pharmacoeconomic study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-8dvw5zp	<NULL>	Be aged 60 years or older; Perform outpatient follow-up by physicians from the study site; Having systemic arterial hypertension, diabetes mellitus and/or dyslipidemia; Having uncontrolled blood pressure, glycemic and/or lipid levels; Taking medication for a period equal to or greater than three months for one of the chronic conditions of the study, these drugs being: losartan potassium together or not with other medications (systemic arterial hypertension), metformin together or not with other medications (diabetes mellitus), simvastatin together or not with other drugs (dyslipidemia); Included patients or caregivers must sign the Free and Informed Consent Form (TCLE)	Patients diagnosed with resistant or secondary systemic arterial hypertension; History of myocardial infarction or stroke in the last six months; Diabetes and/or secondary dyslipidemia; End-stage renal disease (glomerular filtration rate &lt;10mL/min or hemodialysis); Liver disease; Cancer treatment; Acquired immunodeficiency syndrome or anticoagulation; Unstable psychiatric illness; If the patient is already followed up by other clinical pharmacists; Inability to attend scheduled appointments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-5fxbqsf	Comparison of the Effect of two Suturing Techniques after Extraction of mandibular Third molars	Recruiting	Intervention	2022-12-21	<NULL>	<NULL>	5771	Comparison of the Effect of two Suturing Techniques on inflammatory signs after Extraction of mandibular Third molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade de Pernambuco	Faculdade de Odontologia da Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-5fxbqsf	<NULL>	age between 18 to 30 years; present surgical site without current signs and symptoms of infection; present mandibular third molars in similar positions and with indication for extraction	history of pregnancy or lactation; history of allergy to any medication used in the experiment; not participating in all phases of the proposed research; systemic disease; making use of medications that interfere with the procedure on the day or week prior to the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-5cqxrrx	Ketamine effects on Brain Monitoring and Sedation Levels	Recruitment completed	Intervention	2022-12-21	<NULL>	<NULL>	5772	Effects of Ketamine s (+) on PSI-SEDLine Electroencephalogram and Sedation Levels	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2022-08-15	Hospital São Carlos	Hospital São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-5cqxrrx	<NULL>	Volunteers with physical status P1; both genders; age between 22 and 46 years; body mass index between 22 and 26 kg.m-2	Use of drugs that affect electroencephalographic activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-99xvpph	Discovery of proteins that differentiate health and disease around dental implants	Recruiting	Observational	2022-12-19	<NULL>	<NULL>	5768	The searching for novel biomarkers for the diagnosis of peri-implant diseases using proteomic approaches	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Estadual de Maringá	International Team for Implantology	https://ensaiosclinicos.gov.br/rg/RBR-99xvpph	<NULL>	Patients with one or more dental implants with at least 10 years in function treated at Dental Clinic of the State University of Maringá	Medical history that includes serious medical conditions or communicable diseases; Use of immunosuppressive drugs, bisphosphonates or steroids in the last 5 years; Antibiotic therapy or oral prophylactic procedures within the previous 3 months; Conditions that require prophylactic antibiotic coverage prior to dental treatment; Pregnancy or lactation; Subjects who underwent non-surgical treatment for peri-implant disease in the last 6 months; Subjects who underwent surgical treatment for Peri-implantitis in the last two years; Sites with implant-supported rehabilitations with little marginal adaptation and inadequate access to hygiene.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-4rvdvfk	Evaluation of the use of alkalized Lidocaine in tracheal tube inflation in patients undergoing thyroid removal surgery	Recruitment completed	Intervention	2022-12-19	<NULL>	<NULL>	5769	Evaluation of the use of alkalized Lidocaine in endotracheal tube cuff inflation in patients undergoing thyroidectomy surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Hospital São Domingos	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-4rvdvfk	<NULL>	Patients over 18 years of age; men or women; who had undergone total or partial thyroidectomy; Classification of ASA grade I or II; who agreed to sign the free and informed consent	Patients who refused to participate in the study; patients with difficult orotracheal intubation (OTI) (trachea not intubated on the first attempt); smoking patients; cuff rupture during OTI; patients with cardiac, pulmonary, or neuropathies; patients with previous laryngeal and/or tracheal surgeries, with risk of aspiration of gastric contents, and with the need to use a nasogastric tube were excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-3z667w2	Evaluation of Therapeutic Footwear on the foot of people with Diabetes Mellitus	Recruitment completed	Intervention	2022-12-19	<NULL>	<NULL>	5770	Evaluation of the impact of the use of Therapeutic Footwear on the foot of people with type 2 Diabetes Mellitus	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-11-21	Universidade Federal de São Paulo - Escola paulista de Enfermagem	Universidade Federal de São Paulo - Escola paulista de Enfermagem	https://ensaiosclinicos.gov.br/rg/RBR-3z667w2	<NULL>	Individuals with Type 2 Diabetes Mellitus; individuals registered in the municipal public network of São João da Boa Vista-São Paulo; with more than five years of diagnosis; individuals with a previous diagnosis of Peripheral Diabetic Neuropathy; both sexes; age group over 30 years old; individuals who agree to participate in the research and present cognitive conditions (alert individuals, mental capacity to comply with the study requirements voluntarily)	Individuals with cognitive impairment; individuals who stop wearing therapeutic shoes after the intervention begins; pregnancy; active systemic cancer; cervical and lumbar spine diseases; stroke; cerebral palsy; rheumatoid arthritis; lower limb prosthesis; general lower limb surgery; lower limb osteoarthritis; gait instability; charcot disease; plantar hyperkeratosis; neuro-ischemic diabetic foot	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-2fqcbrx	A  study to evaluate the efficacy of Eclipta prostrata (L.) L. in the treatment of atopic dermatitis in children	Not yet recruiting	Intervention	2022-12-16	<NULL>	<NULL>	5766	A double-blind, randomized, placebo-controlled study to evaluate the efficacy of Eclipta prostrata (L.) L. in the treatment of atopic dermatitis in children above 2 years old	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2023-01-09	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - USP	Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FAEPA)	https://ensaiosclinicos.gov.br/rg/RBR-2fqcbrx	<NULL>	Children and adolescents between 2 and 18 years old; clinical diagnosis of atopic dermatitis, according to the Hanifin and Rajka criteria	Diagnosis or presence of acute or chronic cutaneous diseases, not suggestive of atopic dermatitis, that may interfere with the study results; use of corticosteroids, systemic immunosuppressants or immunobiologicals for at least 30 days before or during participation in the study; allergy or serious adverse events attributable to the administration of the investigational product; non-adherence to treatment (ie, not using the investigational product regularly, as prescribed) for at least one continuous month; failure to attend more than 50% of the evaluations (clinical and/or laboratory) that will be carried out during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-6vkxvvd	Benefical effects of meditation on chronic low back pain	Recruiting	Intervention	2022-12-15	<NULL>	<NULL>	5764	Effects of a online Mindfulness-based stress reduction program in individuals with chronic low back pain	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6vkxvvd	<NULL>	Volunteers from 19 to 64 years of age; having low back pain that has persisted for at least three months and has been a constant problem for at least half of the days in the past 6 months, as it characterizes chronic low back pain according to the recommendations of the National Institute&apos;s task force report of Health from National Institutes of Health on research standards for chronic low back pain; access to the internet; and consent and availability to undertake the MBSR program	No have previous participation in a Mindfulness meditation program; not filling in or having any error in filling in personal data, missing important information such as name, age and contact details; use of psychotropic drugs; psychological/psychiatric treatment; neuropsychiatric disorders (such as dementia, dyslexia, schizophrenia, depression, anxiety disorder, autism, etc; and serious chronic conditions, such as cancer, severe heart disease, active tuberculosis, Parkinson&apos;s disease, etc	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-7w6dh9q	Effect of a simulated environment on the knowledge and skills of health course students	Not yet recruiting	Intervention	2022-12-15	<NULL>	<NULL>	5765	Effectiveness of a simulated environment on the knowledge and skills of healthcare students	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Universidade Federal de Juiz de Fora	Faculdade de Enfermagem da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7w6dh9q	<NULL>	Students aged 18 or over. Students who have already taken the Fundamentals and Technologies of Nursing Care	Students who are not attending the course. Students who drop out. Students who do not fully participate in the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-3q685r5	Performance of people with Spinocerebellar Ataxia during the practice of virtual games under different interfaces	Recruiting	Intervention	2022-12-14	<NULL>	<NULL>	5762	Analysis of motor and functional performance of people with Spinocerebellar Ataxia during tasks practice in real and virtual environments: a cross-sectional study	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-21	Faculdade de Medicina da Universidade de São Paulo	Centro de promoção e reabilitação em saúde e integração social do Centro Universitário São Camilo	https://ensaiosclinicos.gov.br/rg/RBR-3q685r5	<NULL>	Confirmed clinical diagnosis for Spinocerebellar Ataxia with exclusively motor impairment; adults between 21 and 64 years old; normal visual acuity (20/12 to 20/25) or close to normal (20/30 to 20/60) even with corrective lenses	Acquired neurological conditions or with hereditary forms who had comorbidities such as intellectual deficit, low vision, dystonia, epilepsy, and/or use medications that could interfere with the variables studied or that interfere with the autonomic system, such as antiarrhythmics and medications for the treatment of diabetes mellitus; Individuals who did not understand or were unable to perform the proposed activities; patients with cardiac arrhythmias and atrioventricular block, congenital anomalies such as congenital heart disease, pulmonary malformations; patients acute or chronic health conditions without sufficient manipulative ability to use a computer keyboard	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-54zyxsk	The effect of Hypnosis in patients with persistent pain related to Fibromyalgia	Recruitment completed	Intervention	2022-12-14	<NULL>	<NULL>	5763	Efficacy of Hypnosis in the management of chronic pain related to Fibromyalgia (HYP-FIBRO)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-22	Clinica Ortopédica e Traumatologica S/A	Fundação Oswaldo Cruz - Instituto Gonçalo Muniz	https://ensaiosclinicos.gov.br/rg/RBR-54zyxsk	<NULL>	volunteers with fibromyalgia; both sexes; age between 18 and 60 years; and moderate to severe chronic pain for at least 6 months; on stable analgesic treatment for chronic pain management for more than 1 month at the time of study enrollment	Patients who are not able to understand the informed consent;who have been treated with hypnosis before or are participating in another clinical trial; and with cognitive impairment of any kind; and with chronic pain caused by other medical condictions and previous surgical procedures  that may affect the study&apos;s efficacy evaluations; with a a history or current of severe psychopathologies (severe depression, schizophrenia, psychosis, etc.) or undergoing treatment with psychotherapy; using opioids in schema not stable as defined by the protocol;and who have undergone any type of surgery whithin 6 months of study entry.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-4r6jhy6	Conservative versus surgical treatment of grade III acromioclavicular dislocations	Not yet recruiting	Intervention	2022-12-13	<NULL>	<NULL>	5761	Conservative versus surgical treatment of grade III acromioclavicular dislocations: prospective and randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-15	Centro de Traumatologia do Esporte da Escola Paulista de Medicina	Centro de Traumatologia do Esporte da Escola Paulista de Medicina	https://ensaiosclinicos.gov.br/rg/RBR-4r6jhy6	<NULL>	Both genders; over 18 years of age; type III acromioclavicular dislocations with up to 21 days of evolution; absence of acromioclavicular dislocation in the shoulder in question; absence of previous surgery on the shoulder in question; absence of concomitant fracture of the acromion, coracoid or clavicle; signing the consent form.	Patients who did not meet the return schedule; patients in whom radiological examinations were not performed correctly; patients who did not comply with the proposed rehabilitation program.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-85kg336	Pharmaceutical follow-up of patients treated in primary care	Not yet recruiting	Intervention	2022-12-09	<NULL>	<NULL>	5760	Implementation of a pharmacotherapeutic service in primary care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-03	Universidade Federal de São João del-Rei (UFSJ)	Universidade Federal de São João del-Rei (UFSJ)	https://ensaiosclinicos.gov.br/rg/RBR-85kg336	<NULL>	In the first phase, pharmacists who work in Primary Health Care of the Unified Health System of the participating municipalities will be included. There are no exclusion criteria at this stage. In the second phase, patients aged 18 years or older with type I Diabetes Mellitus will be included; or type II; or gestational; or adult latent autoimmune diabetes, known as the LADA type; or Maturity Onset Diabetes of the Young MODY; and who are using at least one drug for the treatment of Diabetes Mellitus	Second phase: patients who are not responsible for their own pharmacotherapy and who do not have a caregiver to accompany them to consultations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-9dsnjq8	Effect of Strengthening Exercises on the force transmission between the latissimus dorsi and the gluteus maximos	Not yet recruiting	Intervention	2022-12-07	<NULL>	<NULL>	5759	Evaluation of the effect of Resistance Training on myofascial force transmission between latissimus dorsi and gluteus maximus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9dsnjq8	<NULL>	Healthy volunteers; both genders; aged between 18 and 35 years; body mass index (BMI) less than or equal to 27 kg/m²; at least 25º of passive medial and lateral hip rotation without pain	Individuals who have practiced physical activity in the last three months; musculoskeletal injury or current or recent symptoms (6 months) in the assessed regions; inability to keep Latissimus Dorsi, paraspinal and hip muscles relaxed during the assessment; pain or discomfort during data collection or intervention and that makes it impossible for them to remain in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-4d3kvz5	Effectiveness of Genicular Block image guided with Phenol for the treatment of Chronic Pain due to Knee Ostheoarthritis	Recruiting	Intervention	2022-12-06	<NULL>	<NULL>	5757	Randomized-controlled trial of the effectiveness of Genicular nerve block image guided with Phenol for the treatment of Chronic Knee Pain due to Knee Ostheoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4d3kvz5	<NULL>	"Severe knee pain with pain greater than 6 on the numerical rating scale ;
Knee osteoarthritis  Kellgren-Lawrence classification  2 to 4, uni or bilateral;
More than six months without improvement with conservative treatment"	Patients with cognitive impairment ; Psychiatric illnesses; Other causes of knee pain (trauma, complex regional pain syndrome, rheumatoid arthritis or lumbosciatalgia or sciatica); Puncture site infection; Coagulopathy; Anticoagulant use; Body Mass Index &gt;40kg/m2; Previous Total Knee Arthroplasty	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-6dy4mgj	Evaluation of dental restorations using composites with various translucency levels	Recruiting	Intervention	2022-12-06	<NULL>	<NULL>	5758	Clinical evaluation of restorations in anterior teeth using composites with various levels of translucency: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-6dy4mgj	<NULL>	Two anterior permanent teeth requiring restorations in each patient (two class III or two class IV), large cavities or defective restorations with similar dimensions and including the same number of tooth surfaces; presence of the antagonist and opposing teeth making contact; vital pulp; good oral health, age between 18 and 70 years; both genders	Extremely deep caries lesions, unrestorable crown; mechanical pulp exposure during caries removal; teeth previously treated with direct pulp capping; teeth exhibiting spontaneous or constant pain indicating irreversible pulpitis; severe systemic diseases; allergies to dental composites; periodontal disease; deleterious parafunctional habits and bruxism; hypersensitivity on the teeth to be restored	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-3j4d9ft	Effect of a toothpaste for sensitive teeth on the sensitivity and effectiveness of in-office dental bleaching	Recruitment completed	Intervention	2022-12-05	<NULL>	<NULL>	5755	Effect of a toothpaste for sensitive teeth and repair of enamel on the sensitivity and effectiveness of in-office dental bleaching	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-11-15	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-3j4d9ft	<NULL>	Patients over 18 years of age who sign an informed consent form.	Patients with caries, periodontal disease or changes in enamel; anterior maxillary teeth of color A1 or greater value; having restorations, endodontics, cracks or non-carious lesions in the anterior teeth; allergy to hydrogen peroxide.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-1047jx9p	Omega 3 supplementation on strength and muscle mass in healthy adults	Recruiting	Intervention	2022-12-05	<NULL>	<NULL>	5756	Effectiveness of Omega 3 supplementation on strength and muscle mass in healthy adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Estadual de Campinas	Fundo de apoio ao ensino, pesquisa e extensão da Universidade de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-1047jx9p	<NULL>	Male; 18 to 40 years old; healthy; physically active (according to the International Physical Activity Questionnaire); trained in strength for at least 12 months; who have a 1-Repetition Maximum of at least 2.5 x body weight; and habitual protein consumption ≥ 1.6g/Kg/d	Previous use of anabolic androgenic steroids; current use (in the last 3 months) of ergogenic aids; being engaged in a calorie-restricted diet (&gt; 1 year); medical restriction regarding the practice of physical activity; allergy to omega 3 supplementation or milk protein; any type of chronic disease or orthopedic injury that prevents the practice of strength exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-1025kjwv	The effect of Physical Therapy matrix support in primary care	Recruitment completed	Intervention	2022-12-02	<NULL>	<NULL>	5754	Effectiveness of Physical Therapy matrix support in primary health care: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal dos Vales do Jequitinhonha e Mucurí	Universidade Federal dos Vales do Jequitinhonha e Mucurí	https://ensaiosclinicos.gov.br/rg/RBR-1025kjwv	<NULL>	Act as a community health agent linked to basic health units and accept to participate in the research; both genders	Being on vacation or sick leave during the intervention period; not having a minimum of 75% attendance in face-to-face moments; incomplete responses to the questionnaires;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-9kt87y7	Evaluation of the use of Bone Grafts in Knee Osteotomy Surgery	Recruitment completed	Intervention	2022-12-01	<NULL>	<NULL>	5751	Comparative study between Medial Opening Wedge Osteotomy with Autologous versus Homologous Graft	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-17	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad	https://ensaiosclinicos.gov.br/rg/RBR-9kt87y7	<NULL>	Both genders; age between 20 and 60 years; isolated osteoarthritis of the medial compartment of the knee associated with varus deformity; ligament injury with asymmetric varus axis deviation; preserved range of motion, ie at least 90º flexion and less than 10º flexion contracture; conservative treatment failure; ability to read and understand the Free and Informed Consent Term and agreement to participate in the research	Systemic inflammatory diseases; age over 60 or under 20; planned corrections with calculations larger than 17.5 mm or smaller than 10 mm; previous surgeries on the affected knee; previous infections in the affected limb; pain in the lateral or anterior compartments of the affected knee; lateral meniscus injury; severe osteoarthritis of the knee (grades 4 and 5 of the Ahlbäck classification)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-4ck2fqg	Nutritional Counseling Therapy and Transcranial Direct Current Stimulation on body weight in women with obesity and depression	Recruitment completed	Intervention	2022-12-01	<NULL>	<NULL>	5752	Effect of Nutritional Counseling Therapy Associated with Transcranial Direct Current Stimulation (tDCS) on body weight in individuals with obesity and major depressive disorder: a sham-controlled parallel-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-4ck2fqg	<NULL>	women; with obesity; with major depression; literate; right-handed; who have a Hamilton scale score greater than 18; body mass index greater than 30 kg/m2; adults aged between 18 and 65 years	pregnant women; shift workers; in weight loss treatment in the last 30 days; who underwent bariatric surgery; have a contraindication for the use of transcranial direct current stimulation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-5xnhwsw	The effectiveness of Auricular Vagus Nerve Electrical Stimulation associated with Global Osteopathic Treatment in patients with Fibromyalgia	Not yet recruiting	Intervention	2022-11-30	<NULL>	<NULL>	5965	Effect of Transcutaneous Electrical Stimulation of the Vagus Nerve combined with Osteopathic Global Treatment in women with Fibromyalgia: clinical trial randomized controlled	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-04-03	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5xnhwsw	<NULL>	Female volunteers; residents of greater Florianópolis; clinical diagnosis of Fibromyalgia; over 18 years of age and must sign the Free and Informed Consent Form	Volunteers with cardiovascular diseases; pulmonary; kidneys; oncological; pacemaker; epilepsy; skin pathologies; infection; decompensated metabolic diseases; decompensated arterial hypertension; aquaphobia; joint prostheses that make the technique unfeasible with global osteopathic treatment; associated rheumatologic diseases; cognitive not preserved; musculoskeletal disorders that compromise the execution of the proposed interventions; immunosuppressed; pregnant or lactating women; skin irritation from electrical stimulation; piercing in the area of the concha cava and cymba of the ear where the electrostimulation will be performed; have urinary incontinence; fecal incontinence; decreased skin sensitivity and vestibular dysfunctions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:25
RBR-96jkqmh	Assessment of dental sensitivity after in-office bleaching associated or not to desensitizing methods: a randomized clinical trial	Recruitment completed	Intervention	2022-11-28	<NULL>	<NULL>	5749	Assessment of dental sensitivity presence and intensity after dental bleaching associated or not to desensitizing methods	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-15	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-96jkqmh	<NULL>	Age between 18 and 40 years; Good systemic and oral health, with vital anterior teeth and premolars	Underwent any bleaching procedure (in-home or in-office) or any desensitizing protocol within the last 6 months; Teeth with higher value than B1 (Vita Scale; Dentin hypersensitivity history; Dentin hypersensitivity risk factors: enamel cracks or defects, dentin exposure, gingival recession, non carious cervical lesions, acid diet, gastroesophageal reflux and bruxism; Dental plaque, caries or calculus; and periodontal disease; Unsatisfactory dental restoration; Buccal dental restoration in anterior teeth; Severe staining; Using a toothpaste for sensitive teeth within the time of the research; Pregnants or lactating women; Smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-5cvdrdy	Nutritional supplementation in the prevention and treatment of anemia	Recruitment completed	Intervention	2022-11-27	<NULL>	<NULL>	5748	Effectiveness of nutritional supplementation in the prevention and treatment of anemia in socially vulnerable children	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-04	Ana Paula Grotti Clemente	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-5cvdrdy	<NULL>	Children aged 1 to 6 years, who have a nutritional diagnosis of: very low weight for age, low weight for age or adequate weight for age (&lt; 1 z score) or very short stature and short stature for age (&lt; -2 Z score), according to the indicators Weight for Age and Height for Age (World Health Organization, 2006), and who at the time of recruitment are not using any other supplementation nutritional.	Children with a nutritional diagnosis of high weight for age (&gt;1 z score) will be excluded from the study, as well as those whose guardians report that they have a diagnosis of neurological or genetic and autoimmune hematological diseases (sickle cell, hemolytic, sideroblastic and aplastic anemias, Fanconi anemia and thalassemia) or with a previous diagnosis of iron deficiency anemia due to other nutritional causes (megaloblastic and pernicious anemias).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-9sjh5rm	Bone Evaluation of Dental Implants Produced by 3D Printing in Mandible or Maxilla: clinical study	Not yet recruiting	Intervention	2022-11-25	<NULL>	<NULL>	5747	Marginal Bone Level Assessment of Additive-Manufactured Titanium Implants at 30 and 90 Days: 1-year non-inferiority within-subject randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade de São Paulo - Faculdade de Odontologia	M3 Health Indústria e Comércio de Produtos Médicos, Odontológicos e Correlatos Sociedade Anônima	https://ensaiosclinicos.gov.br/rg/RBR-9sjh5rm	<NULL>	Patients who are a minimum age of 18 years and a maximum of 70 years; with good general health; who have signed the Informed Consent Form; in need of rehabilitation with dental implants in areas of mandible or posterior maxilla (premolars and/or molars); with bacterial plaque index ≤ 20%; bleeding rate ≤ 20%; sufficient alveolar bone volume for an implant of 8 or 10mm length, diameter of 3.5mm, 4.00mm or 4.5mm, with bone quality type I-III and no associated bone regeneration required	Pregnant and lactating women; uncontrolled diabetes; history of chemotherapy or radiotherapy in the last 5 years; radiation therapy to areas of the head and neck; use of immunosuppressants, bisphosphonates or prolonged use of corticosteroids; smokers; alcohol or drug abuse; untreated periodontitis; history of previous bone augmentate in the implant installation region; presence of residual roots at the site to receive the implant; type IV bone density; individuals with connective tissue disorders or bone metabolic diseases; postmenopausal osteoporosis or other systemic diseases that may affect bone metabolism; need for guided bone regeneration at the time of implant placement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-5r8v8qz	High Frequency Chest Wall Oscillation Therapy and the possibility of its use in infants	Recruiting	Intervention	2022-11-25	<NULL>	<NULL>	7916	High Frequency Chest Wall Oscillation Therapy use in infants: feasibility study for a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-20	Faculdade de Ciências da Saúde do Trairí (FACISA) - Universidade Federal do Rio Grande do Norte (UFRN)	Faculdade de Ciências da Saúde do Trairí (FACISA) - Universidade Federal do Rio Grande do Norte (UFRN)	https://ensaiosclinicos.gov.br/rg/RBR-5r8v8qz	<NULL>	Infants from 3 to 6 months old, with one of their guardians; of both sexes; born full term; without health conditions diagnoses or reflux complaints; without respiratory symptoms; which parents or guardians, greater 18 years old, authorize their participation	Participants (infant and guardian) who do not attend three scheduled evaluation attempts	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:37
RBR-688c6mb	Effects of combination of the application of Electric Current and Massage on bruxism	Recruiting	Intervention	2022-11-24	<NULL>	<NULL>	5746	"Effects of Electromassage in adults with bruxism: a randomized clinical trial
controlled"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-688c6mb	<NULL>	Volunteers of both sexes; between 18 and 40 years of age; with a diagnosis of problable bruxism that will be based in the presence of a positive result in the self-report and clinical odontological inspetion	Participants under the age of 18; who do not agree to participate in this study or who have cognitive deficit determined by the MMSE questionnaire - Mini Mental State Examination; hearing deficit that prevents understanding of verbal instructions; neuromuscular disorders and/or trauma-orthopedic conditions that prevent the participant from carrying out the assessments and/or proposed intervention; pregnant or lactating women; individuals diagnosed with cancer and autoimmune diseases; present other associated osteoarticular disorders at the application site; have severe symptoms of depressive disorders and/or anxiety disorders, alcohol and/or drug abuse; daily use of pain control medication (as preventive medication for the treatment of chronic tension headache and/or migraine); present tooth loss of more than two posterior teeth, except third molars; who are on concomitant treatment for bruxism; users of occlusal splints, complete dentures, removable partial dentures and orthodontic appliances; who have not taken at least the first dose of the Covid-19 vaccine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-87x8h69	Evaluation of use of Dolutegravir in children aged 6 to 12 years: a multicenter study in Brazil	Recruiting	Observational	2022-11-23	<NULL>	<NULL>	5743	Effectiveness and safety of Dolutegravir among treatment-experienced children aged 6 to 12 years: a multicenter observational study in Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-10-01	Faculdade de Medicina, Universidade Federal de Minas Gerais/UFMG	Faculdade de Medicina, Universidade Federal de Minas Gerais/UFMG	https://ensaiosclinicos.gov.br/rg/RBR-87x8h69	<NULL>	Children; both genders; from 6 to 12 years of age; weighing 20 kilos or more; infected by HIV (Human Immunodeficiency Virus); using a stable antiretroviral regimen; with a prescription for Dolutegravir.	Any previous exposure to DTG (Dolutegravir) including participation in a clinical trial or a compassionate use/medical need program; history, presence of known allergy, or contraindications to DTG (Dolutegraivr) use; known previous genotypic resistance to Integrase Inhibitor.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-4rj97vw	Evaluation of Surgery for Shoulder Instability with two techniques	Not yet recruiting	Intervention	2022-11-23	<NULL>	<NULL>	5744	Latarjet Surgery: a prospective comparison of the fixation of the screw with and without washer	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-13	Centro de Traumatologia do Esporte	Centro de Traumatologia do Esporte	https://ensaiosclinicos.gov.br/rg/RBR-4rj97vw	<NULL>	Patients with anterior shoulder instability; follow-up in the postoperative period for at least 12 months.	Patients with other shoulder associated conditions such as multidirectional instability; posterior shoulder instability; rotator cuff injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-49qbrs4	Mindfulness, self-compassion and associated factors in the context of parenting	Not yet recruiting	Intervention	2022-11-23	<NULL>	<NULL>	5745	Mindfulness, self-compassion and associated factors in the context of parenting: a study protocol for a randomized clinical trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-49qbrs4	<NULL>	Be over 18 years of age; be a parent of children between 0 and 18 years of age; have an electronic device with internet to watch instructional videos with mindfulness practices, as well as to answer the assessment instruments; having interest and availability of time to practice mindfulness; and agree and sign the Free and Informed Consent Term (ICF)	Being a parent with comorbidity that requires intense care; be responsible for a child or other family member with a condition that requires full dedication;  perform other non-pharmacological mental health therapy and  not know how to read and write	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-45hqzmf	Primary Care in the post-COVID-19 pandemic period: development of a Mobile Health Application	Recruiting	Intervention	2022-11-23	<NULL>	<NULL>	5750	Primary Care after COVID-19: creation of a Mobile Application for the development of health actions	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-07	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-45hqzmf	<NULL>	Age equal to or greater than 18 years; users of the Unified Health System (SUS); diagnosis of Arterial Hypertension (AH) and/or Diabetes Mellitus (DM); accompanied by the Family Health Strategy (ESF) teams	Age less than 18 years old; individuals with serious medical conditions; pregnant women; smoking volunteers; history of alcohol or drug abuse; bedridden; wheelchair users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-5ghn5f4	Digital intervention based on self-compassion for the prevention of mental health in Brazilian university students	Recruiting	Intervention	2022-11-23	<NULL>	<NULL>	6776	Development, evaluation and effectiveness of an mHealth-type intervention based on Compassion-Focused Therapy for mental health prevention among Brazilian university students	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2023-10-09	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5ghn5f4	<NULL>	Be enrolled in a face-to-face course; basic knowledge of the use of smartphones; have a smartphone with internet access and Android or IOS operating system; at least mild depressive, anxiety or stress symptoms	Have a diagnosis of a severe and persistent mental disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-6vb9gn4	Hemolysis after Transfusion of Packed Red Blood Cells by Peripherally Inserted Central Catheter in neonates: randomized clinical trial	Not yet recruiting	Intervention	2022-11-22	<NULL>	<NULL>	5740	Alteration of Hemolysis markers in Packed Red Blood Cell Transfusion using PICC in newborns: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-02-01	Hospital de Clínicas da Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6vb9gn4	<NULL>	Newborns with Peripherally Inserted Central Catheter (PICC) admitted to the Neonatology Service; both sexes with a medical prescription for transfusion of packed red blood cells (pRBCs)	Newborn who has not had blood collected within 24 hours after transfusion; Newborns diagnosed with hemolytic disorders; Newborns receiving vasoactive drug in a single monolumen Peripherally Inserted Central Catheter (PICC); Newborns receiving Total Parenteral Nutrition with osmolarity above 900 milliosmol(mOsm) in a single mono lumen PICC	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-9msvvbq	The effect of Photobiomodulation Therapy in the treatment of Radiotherapy-induced Trismus in Head and Neck Cancer patients	Recruiting	Intervention	2022-11-22	<NULL>	<NULL>	5741	The effect of Photobiomodulation Therapy in the treatment of Radiotherapy-induced Trismus in Head and Neck Cancer patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Irmandade Santa Casa de Misericórdia de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9msvvbq	<NULL>	Adult individuals aged 18 years or older, both sexes, in oncologic follow-up for head and neck cancer treatment at Santa Rita Hospital (ISCMPA) who: have undergone radiotherapy treatment for head and neck cancer; have received medical clearance for treatment with photobiomodulation; have a mouth opening equal to or smaller than 35mm.	Individuals with contraindications for the use of photobiomodulation therapy, according to the manufacturer&apos;s manual: history of photosensitivity; use of photosensitive medications or cosmetics; undiagnosed clinical lesions; those who exceed 30% of absences throughout the treatment will be excluded; also excluded will be patients who evolve with clinical instability and sensory oscillation that limits adequate understanding regarding the techniques involved in this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-9hyfc4v	Electrical Stimulation and the potential therapeutic approach in different populations	Not yet recruiting	Intervention	2022-11-22	<NULL>	<NULL>	5987	Transcranial Direct Current Stimulation and the potential therapeutic approach in different populations	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Faculdade de Ciências da Saúde do Trairí	Hospital Universitário Onofre Lopes	https://ensaiosclinicos.gov.br/rg/RBR-9hyfc4v	<NULL>	Participants were selected from a specialized outpatient service and regarded as suitable to participate in this study if they fulfilled the following criteria: clinical diagnoses of diabetic polyneuropathy; aged from 30 to 69 years; not lactating; no history of brain surgery, tumor, or intracranial metal implantation	Participants with any uncontrolled clinical disease, such as thyroid disease, cardiovascular, pulmonary, haematological or renal disease; alcohol or other substance abuse; pregnancy; lactation; neuropsychiatric disorders; history of epilepsy and metallic implants in the head were excluded; patients with significant cognitive dysfunction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-9nyx8hb	Cardiac Rehabilitation after Myocardial Infarction	Recruiting	Intervention	2022-11-22	<NULL>	<NULL>	6326	Efficacy of Cardiac Rehabilitation after Acute Myocardial Infarction: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-23	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9nyx8hb	<NULL>	Clinical diagnosis of acute myocardial infarction (ECG and cardiac enzymes) with or without ST elevation and uncomplicated (Killip I or II); successfully submitted to percutaneous coronary intervention (PCI) (Flow Timi 3 or 2); age group between 18 and 70 years; both sexes;  classified as low risk (Absence of ventricular dysrhythmias, absence of clinical depression and absence of ischemic signs after the procedure)	Osteomioarticular alterations that prevent the performance of exercises; signs and symptoms of ischemia or cardiac decompensation; atrial or ventricular arrhythmias; EF (Ejection Fraction) &lt; 50%; diagnosed chronic lung diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-8ywgvm8	The effect of an App for cell phones and tablets on the blood glucose of elderly people with Type 2 Diabetes	Not yet recruiting	Intervention	2022-11-21	<NULL>	<NULL>	5737	Effectiveness of a mobile device Application on glycated hemoglobin in elderly people with Type 2 Diabetes Mellitus: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-06	Universidade de Brasília - Faculdade de Ceilândia	Secretaria de Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-8ywgvm8	<NULL>	Elderly aged between 60 and 75 years of both sexes; literate; access to electronic mobile devices; Internet access; medical diagnosis of type 2 diabetes for at least one year; use of oral medication for type 2 diabetes; able to have independence and autonomy to perform activities of daily living that will be measured by the Barthel index; in need of adaptation or supervision by third parties to carry out activities of daily living; who do not practice physical activity or who have insufficient physical activity, assessed using the International Physical Activity Questionnaire (IPAQ) short version	Elderly people using insulin; with multiple chronic comorbidities such as cancer, rheumatoid arthritis, congestive heart failure, severe depression, emphysema, Parkinson&apos;s disease, myocardial infarction, stroke, class III chronic renal failure or worse, end-stage disease such as metastatic cancer, class 4- 5, chronic lung disease requiring oxygen therapy, dialysis patients, severe functional and cognitive impairment; participants in another clinical trial, research study, or exercise program in which they perform similar balance and strength activities; have mobility limitations or use walking devices; diagnosis of progressive neurological disease or other acute or unstable medical condition that prevents exercise; cardiac risk classification II, III and IV according to the New York Heart Association (NYHA) Functional Classification	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-7cztcpk	Performance of Physical Exercise on Cognition, Creativity and Performance in Childrens and adults	Not yet recruiting	Intervention	2022-11-21	<NULL>	<NULL>	5738	Effects of Physical Exercise on Cognition, Creative Thinking and Occupational Performance in childrens and adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-09	Faculdade de Fisioterapia e Terapia Ocupacional da Universidade Federal do Pará	Faculdade de Fisioterapia e Terapia Ocupacional da Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-7cztcpk	<NULL>	Healthy participants; age between 08 to 59 years; both genders; assets in the educational institution; accept sign the Free and Informed Consent Term (FICT) to participate in the study, in case of participants under 18, the consent form must be signed by the legal guardian	Participants with cardiac, neurological or physical pathologies; under 8 years old and over 59 years old; who use drugs that influence the central nervous system; licit and/or illicit drug users; who do not agree to sign the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-6nxjzt6	Clinical study to assess the Impact of Therapeutic Exercise on Cardiac Autonomic Function after Cardiac Surgery	Recruiting	Intervention	2022-11-21	<NULL>	<NULL>	5739	Impact of an individualized Therapeutic Exercise Protocol on Heart Rate Variability in the postoperative Heart Surgery: Randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Hospital universitário da Universidade Federal do Maranhão (HUUFMA)	Hospital universitário da Universidade Federal do Maranhão (HUUFMA)	https://ensaiosclinicos.gov.br/rg/RBR-6nxjzt6	<NULL>	Over 18 years of age; both sexes; undergoing heart surgery for myocardial revascularization, valve replacement or plasties, aortic surgeries and combined surgeries; provide written consent.	Neurological disorders that interfere with the ability to understand; heart surgery without cardiopulmonary bypass; inability to perform the proposed exercise protocol; surgical re-approach.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-6kzkbty	Evaluation of the influence of intermittent fasting on food intake, weight, hunger and satiety, and hormonal parameters in healthy women	Recruiting	Intervention	2022-11-19	<NULL>	<NULL>	5736	Evaluation of the influence of intermittent fasting on caloric ingestion, body and nutrition composition, hunger and saciety, and hormonal parameters in healthy women: a prospective cross cohort study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-02	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6kzkbty	<NULL>	To participate in the study will be selected 30 female volunteers, aged between 20 and 40 years.	Volunteers who use medicine, hormones and thermogenic supplements, with pre-existing pathologies, pregnant and postpartum women, menopause and early menopause, women with hysterectomy, injectable contraceptives, any medications or supplements known to affect sleep cannot participate. at night, eating disorders, nocturnal eaters and alcohol consumption in general.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-10b6jkd2	The effect of Speech Therapy associated to Laser Therapy on swallowing in the elderly	Not yet recruiting	Intervention	2022-11-18	<NULL>	<NULL>	5733	Controlled and randomized clinical study of the effect of Orofacial Myotherapy associated with Photobiomodulation in elderly with presbyphagia	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-10b6jkd2	<NULL>	Seniors; age over 60 years; complaints of difficulty in chewing and/or swallowing (Dysphagia)	Individuals with neurological diseases; elderly with cognitive impairment; head and neck tumor resection surgery; tracheostomized patients; patient with pathology in the thyroid region; elderly people with mobility difficulties or need for a companion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-7j4rkbz	Functional Capacity and Fatigue in Children and Adolescents in Cancer Treatment Performing Physical Activity	Recruitment completed	Intervention	2022-11-18	<NULL>	<NULL>	5735	Functional capacity and fatigue levels in children and adolescents undergoing Oncological treatment submitted to a Physical Activity Protocol	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-10	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7j4rkbz	<NULL>	Have been diagnosed with cancer; Children and adolescents aged between 4 and 15 years old, of both sexes; Being undergoing outpatient cancer treatment at Joana de Gusmão Children&apos;s Hospital; Who are at any stage of treatment; Performing any type of cancer treatment (Chemotherapy, Radiotherapy, surgery, among others); Who present cognitive conditions to participate in the research, which will be evaluated from the direct observation of the researchers, in contact with the parents; That present motor conditions to carry out the tests of strength production capacity and functional capacity	Neuromotor impairment; The medical team considers it unfeasible; Momentary incapacity that makes it impossible for them to perform the pre-intervention assessment or that, at the time of the anamnesis, some incapacity is verified, such as (extreme tiredness, malaise, discomfort); Parents or patients refuse to sign the consent form;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-8wd82p8	Effect of Osteopathic treatment for patients with knee Arthrosis	Not yet recruiting	Intervention	2022-11-17	<NULL>	<NULL>	5731	Effects of Visceral Manipulation associated or not with Structural Techniques on pain, range of motion, activation and muscle strength of individuals with knee Osteoarthritis: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Instituto Docusse de Osteopatia e Terapia Manual	Faculdade de Ciências e Tecnologia do Campus de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-8wd82p8	<NULL>	To be included in this study, participants must be over 40 years-old; medical diagnosis of knee osteoarthritis; pain for more than three months; have at least one of the following symptoms: limited range of motion, crepitus, difficulty/pain when going up and down stairs, walking, standing up or sitting in a chair	Exclusion criteria for the present study are history of knee surgery; presence of rheumatoid arthritis; initiation of opioid analgesia or intervention with corticosteroid injection or analgesic for knee pain within the last 30 days; inability to understand and complete study assessments or comply with study instructions; neurological diseases that could influence the investigated outcomes (e.g., stroke)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-108jqppd	Intervention for health promotion and obesity prevention in the school environment (Daycare Centers: Place of Play &amp; Health)	Recruiting	Intervention	2022-11-17	<NULL>	<NULL>	5732	Intervention for health promotion and obesity prevention in “Generation C” children in the school environment (Daycare Centers: Place of Play &amp; Health): a cluster randomized controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-08	Universidade Estadual da Paraíba	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-108jqppd	<NULL>	Preschool age children	Children up to two years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-104xsgky	Effects of the Animal Fun Program on movement and psychosocial performance in children aged between 4 and 6 years	Not yet recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5724	Effects of the Animal Fun Program on motor and psychosocial performance in children aged between 4 and 6 years	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-20	Departamento de Ciências do Movimento Humano	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-104xsgky	<NULL>	Children aged 4 to 6 years old can participate in the Animal Fun programme; enrolled; signed informed consent form (TCLE) and assent form (TELE).	not being able to perform the Movement Battery Assessment for Children (MABC-2).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-9z76pk4	Antibiotic prevention with Levofloxacin in children with Acute Lymphoblastic Leukemia	Recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5725	Antibiotic prophylaxis with Levofloxacin in chemotherapy induction in children with Acute Lymphoblastic Leukemia - a randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-07-07	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-9z76pk4	<NULL>	Patients with an initial diagnosis of Acute Lymphoblastic Leukemia; age from 1 year to 18 years.	Children with clinically or microbiologically documented infection before initiation of induction or with fever before induction therapy that required prolonged antibiotic therapy (more than 5 days); history of allergy to the use of quinolones; history of chronic arthritis being treated; patients who developed febrile neutropenia within the first 7 days of induction.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-104bdhff	Zinc supplementation in patients with Head and Neck Cancer in Radiotherapy	Not yet recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5726	Effectiveness of Zinc supplementation on Dysgeusia in patients with Head and Neck Cancer submitted to Radiotherapy: a randomized clinical test protocol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-15	Liga Norte Riograndense Contra o Câncer	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-104bdhff	<NULL>	Patients with head and neck cancer; age between 19 and 65 years; under radiotherapy treatment, of both genders.	Gastrointestinal tract disorders; exclusive alternative food route, such as total parenteral nutrition (TPN) and enteral nutritional therapy (ENT); Exocrine pancreatic insufficiency; Tongue or palate demolition surgery; Sjögren&apos;s syndrome, considering that the pathophysiology of this disease can affect the salivary glands and impair taste; Diagnosis for Covid-19 with presence of dysgeusia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-2frpntv	Development of a Protocol for using Steroids after Cataract Surgery	Not yet recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5727	Development of a Cost-effective Corticosteroids Protocol in the postoperative Cataract Surgery	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-12-01	Instituto para o Desenvolvimento da Educação Ltda-IPADE/Faculdade	Universitary Center Christus (Centro Universitário Christus - Unichristus)	https://ensaiosclinicos.gov.br/rg/RBR-2frpntv	<NULL>	Patients with cataracts; Over 18 years old; Patients from Instituto Cearense de Oftalmologia cataracts department; Patients who do not have other eye conditions that cause eye inflammation, increased intraocular pressure, decreased visual acuity and macular edema, including diabetic retinopathy; Patients who accepted to participate the study signed the informed consent form.	"Ocular affections which cause inflammation, elevated intraocular pressure, reduced vision acuity and macular edema; Allergy to corticosteroids; Any condition that could interfere to the correct use of the eye drops, including patient&apos;s social and/or economic situation; Use of any eye drops, except lubricants
Ocular or systemic use of Non-steroidal anti-inflammatory drugs, corticosteroids, immunosuppressives or anti-histaminics 2 days before to 21 days after the surgery"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-5zk8ycg	Low-level Laser in breastfeeding Pain: a randomized clinical trial	Recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5728	Effectiveness of Photobiomodulation Therapy on Pain during breastfeeding: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-27	Escola de Enfermagem de Ribeirão Preto - Universidade de São Paulo	Centro de Referência da Saúde da Mulher	https://ensaiosclinicos.gov.br/rg/RBR-5zk8ycg	<NULL>	Women over 18 years of age who present unilateral and/or bilateral nipple trauma with pain complaints during the postpartum hospitalization period.	Pain level below 4; using some topical treatment for nipple trauma other than breast milk, with complications or breast surgeries and women with difficulty understanding; newborns with short frenulum; twins; premature infants (less than 36 weeks and 5 days) and those using neonatal phototherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-3bc3rnb	Elaboration and acceptance of a cocoa and goat milk product in human health	Recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5729	Elaboration and acceptance of a product based on nanoencapsulated cocoa with goat whey protein concentrate and evaluation of its functional properties in human health	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-06	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3bc3rnb	<NULL>	Adult individuals aged between 18 to 40 years; eutrophic with a body mass index between 18.5 and 24.9 kilograms per square meter; of both sexes; healthy	Having cardiovascular and pulmonary diseases; diabetes mellitus; hypertension; dyslipidemia; smoking; urinary tract infection; pregnant women; lactating women; use of drugs that interfere with the vascular system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-9djq4z9	Lung capacity, socioeconomic and symptom profile of adult patients after a year or more of COVID-19 infection	Recruiting	Intervention	2022-11-16	<NULL>	<NULL>	5730	Cardiorespiratory capacity, symptomatic and socioeconomic profile of adult patients after one year or more of COVID-19 infection: a cross-sectional study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-9djq4z9	<NULL>	Survived COVID 19 who completed the disease cycle by April 2021;Patients who have one or more persistent symptoms after COVID-19; Patients 30 years of age or older.; Patients who accepted to be part of the research by signing the informed consent.	They have symptoms of COVID 19 up to 5 days before the evaluation.; Pregnant or lactating patients.; Patients totally dependent on a wheelchair; Patients with severe cognitive impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-9ztp7q7	Effect of Photobiomodulation on tissue healing in Palatal Graft Donor Areas	Recruitment completed	Intervention	2022-11-16	<NULL>	<NULL>	6743	Effect of Dual-Wavelength Photobiomodulation on tissue healing of Connective Tissue Graft Donor Areas	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9ztp7q7	<NULL>	Necessity for periodontal surgery for root coverage with the need for a connective tissue graft; lack of previous experience with wound treatment in soft tissue graft donor regions; ability to maintain good oral hygiene; being systemically healthy or have systemic diseases compensated; being between 18 and 60 years old; both genders	History of untreated periodontal disease; smoking patients, lack of availability of a subepithelial or free gingival connective tissue graft donor bed; hypersensitivity to any anesthetic; medication or antiseptic product used in surgery; medical limitation for elective surgical procedures; patients undergoing orthodontic treatment and pregnant or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-4q69573	Transcranial Electrical Stimulation for chronic pain relief in individuals with Endometriosis	Not yet recruiting	Intervention	2022-11-14	<NULL>	<NULL>	5720	Transcranial Direct Current Electrostimulation for chronic pain relief in individuals with Endometriosis: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4q69573	<NULL>	Age range from 18 to 40 years; diagnosis of endometriosis; having a pain score greater than 3; cognitive ability to understand and answer questionnaires; tolerance to electrical stimulation treatment	Severe headache; dizziness or migraine; having other chronic urinary tract and/or gynecological diseases; being in the puerperal period; be breastfeeding; having a history of brain surgery; presence of tumors; having epileptic disease; have a history of alcohol or drug abuse; have metal implants in the head; have a history of previous gynecological surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-72vws64	Effects of the association of an Intensive Physical and Behavioral Therapy and the Feedback of Movement Imagination on the functionality of the severely upper limb affected by Stroke: a clinical, controlled, randomized and blinded trial	Recruiting	Intervention	2022-11-14	<NULL>	<NULL>	5721	"Effects of the association of Constraint Induced Therapy and the Brain Interface
Machine in the functionality of the severely upper limb affected by Stroke: clinical, controlled, randomized, blinded trial"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-18	Universidade Cidade de São Paulo	Associação de Assistência a Criança Deficiente	https://ensaiosclinicos.gov.br/rg/RBR-72vws64	<NULL>	Stroke more than six months before the beginning of the protocol; age between 18 and 80 years; hemiparesis as a sequela of stroke; score on the Fugl Meyer scale for the upper extremity ≤53 points (moderate and severe injuries), but present at least 30º of shoulder flexion and/or abduction and 10º of elbow extension (from 90º flexion), as well as, greater impairment in the hand most affected by the stroke, evidenced by the deficit in the active extension of the fingers of the hand most affected by the stroke (towel test: should not be able to pick up a face towel from a table and release it more than three times in a minute ); finger flexor tone of the most affected hand &lt;3, assessed by the Modified Ashworth scale; ability to understand simple commands and instructions for assessments and intervention protocols; be available to attend assessments and therapy for 15 consecutive days and remain 3 hours/day in treatment	Inability to interrupt other physical therapies during intervention protocols; language alteration that makes the participant unable to understand, as well as respond appropriately to the proposed assessment scales, interaction with the brain-machine interface and the exercises selected for each protocol; surgery less than 6 months ago, chemical block in the upper limb most affected by stroke less than 3 months ago	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-9d5t69p	Influence of drug use on the performance of chemoterapy treatment in children with cancer	Recruiting	Intervention	2022-11-14	<NULL>	<NULL>	5722	Influence of the use of premedication on peg asparaginase activity in children undergoing treatment for acute leukemia	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2020-09-16	Hospital de Clínicas de Porto Alegre	Servier	https://ensaiosclinicos.gov.br/rg/RBR-9d5t69p	<NULL>	Patients diagnosed with acute lymphoblastic leukemia; in the first line of treatment; under 21 years of age; using PEG (polyethylene glycol) asparaginase; both gender	Patients who do not accept to participate; do not use PEG (polyethylene glycol) asparaginase; over 21 years old	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-7dm3sp7	Clinical evaluation of Restorations in Anterior Teeth with Composite Resin using the cloud shades concept	Not yet recruiting	Intervention	2022-11-14	<NULL>	<NULL>	5723	Clinical evaluation of Restorations in Anterior Teeth with Composite Resin using the cloud shades concept: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-02	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP	https://ensaiosclinicos.gov.br/rg/RBR-7dm3sp7	<NULL>	Two anterior permanent teeth requiring restorations in each patient (two class III or two class IV), large cavities or defective restorations with similar dimensions and including the same number of tooth surfaces; presence of the antagonist and opposing teeth making contact; vital pulp; good oral health, age between 18 and 70 years; both genders	Extremely deep caries lesions, unrestorable crown; mechanical pulp exposure during caries removal; teeth previously treated with direct pulp capping; teeth exhibiting spontaneous or constant pain indicating irreversible pulpitis; severe systemic diseases; allergies to dental composites; periodontal disease; deleterious parafunctional habits and bruxism; hypersensitivity on the teeth to be restored	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-5xpmkwf	Effect of Low-Intensity Laser with Red and Infrared lLight on healing of Gingival Recessions treated with different types of Soft Tissue Graft	Recruitment completed	Intervention	2022-11-14	<NULL>	<NULL>	6710	Effect of Dual-Wavelength Photobiomodulation on tissue healing after Root Coverage associated with different Soft Tissue Substitutes. A clinical, controlled randomized study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-5xpmkwf	<NULL>	Present bilateral single or multiple gingival recessions classified as RT1 (Miller class I and II) that require surgical treatment; lack of previous experience with surgical treatment for the treatment of gingival recessions; ability to maintain good oral hygiene, be systemically healthy or who have compensated systemic diseases; be legally responsible for their own acts, be between 18 and 60 years of age	History of untreated periodontal disease; smoking patients; furcation lesion in the tooth to be treated; presence of severe crowding, rotation or malposition of the tooth to be treated; hypersensitivity to any anesthetic; medication or antiseptic product used in surgery; medical limitation for elective surgical procedures; patients undergoing orthodontic treatment, and pregnant or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:53
RBR-6rrbtsd	Effect of Virtual Reality in the treatment of Chronic Neck Pain	Recruiting	Intervention	2022-11-10	<NULL>	<NULL>	5717	Virtual Reality in the management of Chronic Neck Pain: a pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-10	Universidade Regional de Blumenau	Universidade Regional de Blumenau	https://ensaiosclinicos.gov.br/rg/RBR-6rrbtsd	<NULL>	History of persistent pain in the cervical region, delimited posteriorly by the superior nuchal line to the spine of the scapula and laterally to the superior border of the clavicle and the sternal notch, presenting or non-irradiation to the head, trunk and upper limbs, for at least three months; score of 3 or more points on the Numerical Pain Scale (END) during movement; Cervical Disability Index (NDI) equal to or greater than 20%, that is, 10 points.	History of previous rheumatic diseases, infectious or inflammatory diseases, tumors, cervical myelopathy, vertebrobasilar insufficiency and central or peripheral neurological disorders; history of trauma, fracture, or major surgery in the cervical, thoracic, or upper limbs; signs of nerve root compression such as decreased sensitivity of upper limb dermatomes, significant muscle weakness in upper limbs, decrease, abolition or increase in biceps and triceps reflexes; pregnancy; visual deficit without adequate correction; history of motion sickness, nausea, dizziness, vertigo and/or syncope without and with the use of the virtual reality device.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-57v9mrb	Comparison between models of resistance training volume progression on strength and muscle mass	Not yet recruiting	Intervention	2022-11-10	<NULL>	<NULL>	5719	Comparison of volume load progression models in Resistance training in strength gains and muscle hypertrophy: a within-subject randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-23	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-57v9mrb	<NULL>	Healthy young people; both sexes; age between 18 and 35 years	Have practiced resistance training in the last 6 months; Musculoskeletal injury of lower limbs; neuromuscular disorders that may prevent the execution of the protocols proposed by the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-9gdssk9	Distance-Oriented Exercises for patients with Cystic Fibrosis	Not yet recruiting	Intervention	2022-11-09	<NULL>	<NULL>	5713	Telerehabilitation of individuals with Cystic Fibrosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-30	Faculdade de Educação Fisica e Fisioterapia	Hospital de Clínicas da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9gdssk9	<NULL>	Patients with a confirmed diagnosis of cystic fibrosis; age between 12 and 34 years; with a Shwachman Kulczycki (SK) severity score greater than 7 (less severe disease); who agree to participate in the research; that have pulse oximeter monitoring available and internet access via cell phone or computer	Patients with significant cognitive and or orthopedic alterations; comorbidities that limit physical activity; pregnant women; patients who did not perform the exercise protocol for more than one week; those who for some reason do not keep in touch via cell phone or computer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-76j763k	Vitamin K3 treatment in Stomach Cancer patients in a public hospital	Recruiting	Intervention	2022-11-09	<NULL>	<NULL>	5714	Treatment with Menadione in patients with Gastric Cancer in the Unified Health System	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2022-02-01	Hospital Ophir Loyola	Hospital Ophir Loyola	https://ensaiosclinicos.gov.br/rg/RBR-76j763k	<NULL>	Patients with locally advanced (T2, T3 or T4) and/or incurable disease; with a performance status between 0 and 2 according to the criteria defined by the Eastern Cooperative Oncology Group or greater than or equal to 60% by the Karnofsky performance status; with adequate organ and bone marrow functions and left ventricular ejection fraction above 50%	Patients with brain metastases, angina, intestinal obstruction, active gastrointestinal bleeding and an estimated life of less than three months; with clinically significant comorbidities that may interfere with treatment tolerance and efficacy; on warfarin	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-2p4gpvk	Effects of Resistance Training on Heart Rate Variability and Functional Functional Capacity in Menopaused women: a randomized clinical trial	Recruitment completed	Intervention	2022-11-09	<NULL>	<NULL>	5715	Effect of Resistance Training on Heart Rate Variability, Health Parameters, Functional Parameters and Cognitive Parameters in the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-22	Victor Silveira Coswig	Programa de pós-graduação em ciências do Movimento Humano	https://ensaiosclinicos.gov.br/rg/RBR-2p4gpvk	<NULL>	untrained women; declare postmenopausal for &gt; 1 year	Osteoarticular diseases; history of alcohol consumption or smoking; fail to complete assessments; fail to complete eight meetings during the 6-month period of the protocol; suffer an adverse event during the intervention; present any chronic or acute condition that may compromise performance during the research; have performed any resistance training program in the last six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-8j2jb7y	The Effects of the technique (ILIB) on nonspecific chronic low back pain	Recruitment completed	Intervention	2022-11-09	<NULL>	<NULL>	5716	Effects of different tissue stimuli on functional behavior and motor action	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-12	Laboratório de Avaliação Funcional e Performance Motora Humana - LAFUP	Laboratório de Avaliação Funcional e Performance Motora Humana - LAFUP	https://ensaiosclinicos.gov.br/rg/RBR-8j2jb7y	<NULL>	Present age between 18-35 years; both genders; nonspecific chronic low back pain; volunteer; belong to Londrina (PR)	Neurological disease; cardiorespiratory disease; vascular disease; metabolic disease; high-severity orthopedic disease; loss of balance; labyrinthine crises; epileptic seizures; convulsive crises; mental issue; attention and speech disorders; use vasodilators and/or anticoagulants; use anti-inflammatory drugs and/or analgesics and/or muscle relaxants in the last week; photosensitivity. dermatitis; presence of tattoo in the area and/or lymphedema, cancer; pregnancy; spine and/or locomotor system surgery; perform physiotherapeutic treatment during the research; not present inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-7xhvw6n	Effect of Neuromodulation associated with Gametherapy on upper limb function and brain activity in children with Down Syndrome: double-blind, placebo-controlled, crossover clinical trial	Not yet recruiting	Intervention	2022-11-08	<NULL>	<NULL>	5710	Effect of Transcranial Direct Current Stimulation associated with Gametherapy on function, upper limbs reaching movement and brain activity in children with Down Syndrome: crossed, placebo-controlled and double blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-10	Universidade Evangélica de Goiás	Universidade Evangélica de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-7xhvw6n	<NULL>	Diagnosis of Down Syndrome; adequate understanding and cooperation during proceedings;age between six and twelve years; impairment of upper limb motor coordination and declaration of free and informed consent signed by a legal guardian; neurotypical; adequate understanding and cooperation during proceedings; age between six and twelve years; declaration of free and informed consent signed by a legal guardian, consent form signed by the child.	Children who have undergone surgical procedures in the twelve months prior to the beginning of the training sessions; orthopedic deformity of the lower limbs or spine with surgical indication; uncontrolled epilepsy; metallic implant in the skull or hearing aids; associated neurological disorder; and pacemaker use; associated neurological disorders, bone deformity in the lower and upper limbs, uncorrected visual deficit.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-2zd2rgy	Effects of moderate training and high-intensity training on measures of metabolism and liver health in adults	Not yet recruiting	Intervention	2022-11-08	<NULL>	<NULL>	5711	Effects of Continuous Moderate Intensity Training and High Intensity Interval Training on physiological and pathological makers of Metabolic Syndrome and hepatic health in adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Instituto de Pesquisa da Capacitação Física do Exército	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2zd2rgy	<NULL>	Male sex; military personnel from the Army Physical Training Center and/or from the 1st Guards Battalion; submitted to a weekly nutritional control; and signature on the free and informed consent term.	military personnel who have undergone any type of abdominal surgery, or with any type of osteoarticular or musculoskeletal injury and other clinical conditions that prevent them from performing any of the assessments, which limit movements or who are undergoing restrictive medical treatments; Military personnel who are using any substance or drug capable of altering the test results; Military personnel who are unable to attend all stages of data collection or who are considered physically unfit by a previous medical assessment, especially cardiopulmonary health assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-9xbptxt	Telephone contact in the promotion of self-care of women in the postoperative period for Breast Cancer: a randomized clinical trial	Recruiting	Intervention	2022-11-08	<NULL>	<NULL>	5712	Telenursing in the promotion of self-care of women in the postoperative Breast Cancer:randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Departamento de Enfermagem da Universidade Federal do Ceará	Departamento de Enfermagem da Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-9xbptxt	<NULL>	Age equal to or greater than 18 years; Surgical therapy with a scheduled date; Have been seen in a preoperative nursing consultation	Surgical management that includes replacement of the expander for a definitive prosthesis whose therapeutic surgery took place at another time, removal of the expander or prosthesis due to surgical site infection, hematoma drainage or other surgical complication; Hearing acuity affected, which makes communication via telephone impossible. This characteristic will be proven by means of the Whisper Test propaedeutics (LABANCA et al, 2017); Mental restrictions, proven by medical diagnosis that prevent the understanding of the intervention; Self-care deficit prior to surgery, detected by the Self-Care Assessment Scale (EACAC), whose score is less than 56, which refers to poor or poor capacity for self-care even before the surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-10myxdss	Comparative study of self-report scales in cancer patients undergoing oral antineoplastic medications such as tyrosine kinase inhibitors	Not yet recruiting	Intervention	2022-11-07	<NULL>	<NULL>	5706	Use of the patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE) short version and MDASI in patients with Cancer patients submitted to oral antineoplastic medications such as Tyrosine Kinase Inhibitors: a comparative study of the 2 scales	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal de São Paulo	Hospital Alemão Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-10myxdss	<NULL>	older than 18 years; being treated with TKI alone as anticancer therapy, orally and for 3 months or more; being diagnosed with one of three cancers: kidney, lung, or chronic myeloid leukemia; Performance status between 0 and 2, evaluated according to the Eastern Cooperative Oncologic Group – ECOG scale	multiple comorbidities (3 or more), partial completion of one of the data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-8gyj2fc	Effects of meditation and physical exercise on stress levels	Recruiting	Intervention	2022-11-07	<NULL>	<NULL>	5707	Effects of meditation and functional training on stress levels and its association with neurobehavioral, autonomic and vascular functions in doctoral students	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-22	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8gyj2fc	<NULL>	Regular students in academic doctoral courses of both sexes	Doctoral students who are taking special courses (isolated courses) and doctoral programs in the professional modality. Students with a diagnosis that prevents them from participating in the research will also be excluded (people with severe uncorrected hearing and/or visual impairment), who are using some type of pharmacological medication that may influence the evaluated variables (for example, antidepressants, anxiolytics, corticosteroids) , statins, beta-blockers, anti-inflammatory drugs, stimulants, etc.), students who do not have access to the internet and/or electronic devices (cell phone, computer, tablet, etc.), with a history of some type of mental disorder, cardiovascular disease, diabetes mellitus, syndrome of Raynaud`s, who answered “YES” to one or more questions on the Physical Activity Readiness Questionnaire (PAR-Q), who participated regularly or had attended physical exercise and/or meditation programs in the last three months, smokers and participants of the research that do not carry out 75% of the planned interventions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-7x22bcc	Clinical, microbiological and immunological adjunctive effect of photodinamyc therapy in periodontal maintenance therapy.	Recruitment completed	Intervention	2022-11-07	<NULL>	<NULL>	5708	Clinical, microbiological and immunological adjunctive effect of photodinamyc therapy in residual periodontal pockets in periodontal maintenance therapy: a split-mouth randomized controlled trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Minas Gerais	Universidade de Taubaté	https://ensaiosclinicos.gov.br/rg/RBR-7x22bcc	<NULL>	Present at least one appointment for periodontal maintenance therapy in the 12-month interval; bilateral presence of greater equal 2 interproximal sites with a probing depth greater equal 5 mm; clinical attachment levels greater equal 4mm and presence of bleeding on probing (not same tooth)	Patients who were absent from maintenance therapy for more than 12 months. diabetics; former/ somoking; antibiotic use for any purpose within 3 months prior to entering the study; pregnancy and/or lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-49zrxsx	Surgical distance Mentoring versus face to face Mentoring in the training of Scleral Fixation surgeries for intraocular lenses	Not yet recruiting	Intervention	2022-11-04	<NULL>	<NULL>	5702	Telementoring versus Presential Mentoring in the Training of Scleral Fixation surgeries for intraocular lenses	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-12-04	Universidade Federal de São Paulo	Alcon Brasil cuidados com a saúde LTDA	https://ensaiosclinicos.gov.br/rg/RBR-49zrxsx	<NULL>	Ophthalmologist volunteers; both genders; no age restrictions; no previous experience with the scleral fixation technique of the Akreos lens with GoreTex sutures	Ophthalmologist volunteers with previous experience in the technique of scleral fixation of the 4-haptic scleral lens fixation (Akreos® - Bausch Lomb) using polytetrafluoroethylene sutures (GoreTex®)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-4q3xpdt	Lymphatic Drainage and Taping  in the treatment of edema in pregnant women	Not yet recruiting	Intervention	2022-11-04	<NULL>	<NULL>	5703	Lymphatic Drainage and Taping  in the treatment of edema in pregnant women: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-20	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4q3xpdt	<NULL>	Pregnant women at usual risk (normotensive, without cardiac or vascular pathologies, pulmonary, without high cholesterol levels, gestational diabetes or renal failure); age group between 18 and 34 years; being between the twenty-seventh and thirty-eighth week of gestation; edema in the lower limbs	Present skin lesions in the area of the lower limbs that make manual lymphatic drainage or taping application impossible; not attending sessions; not complete the assessment procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-10j2hgds	Study of the effectiveness of the D3 Scleral Contact Lens to assist the Epi-on Crosslinking Surgical Procedure (treatment for Keratoconus disease)	Terminated	Intervention	2022-11-04	<NULL>	<NULL>	5704	Study of the effectiveness of the D3 Scleral Contact Lens to assist Epi-on Crosslinking	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Hospital Universitário Gaffree e Guinle/HUGG/UNIRIO	Mediphacos Indústrias Médicas S.A.	https://ensaiosclinicos.gov.br/rg/RBR-10j2hgds	<NULL>	Patients aged 12 years or older; patients diagnosed with keratoconus and a history of ectasia progression in the last 12 months or at risk of progression; minimum corneal thickness of 300 microns	Patients without indication for the treatment of Crosslinking; corneal thickness less than 300 microns; Vulnerable groups: pregnant women, breastfeeding women, children under 12 years of age, individuals whose capacity for self-determination is reduced or impeded, or in any way prevented from resisting, especially with regard to free and informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-9vh37wr	Amamentar durante a vacinação ajuda a reduzir a dor do bebê aos dois meses de vida	Recruiting	Intervention	2022-11-04	<NULL>	<NULL>	5705	Effectiveness of Breastfeeding in reducing Pain induced by the Pentavalent Vaccine in the second month: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal do Piauí - Campus Amílcar Ferreira Sobral	Universidade Federal do Piauí - Campus Amílcar Ferreira Sobral	https://ensaiosclinicos.gov.br/rg/RBR-9vh37wr	<NULL>	Infants aged between 60 and 89 days; who are breastfed; who were born with a gestational age of 37-42 weeks; no visible and/or reported congenital malformations by the mother; in need of Pentavalent vaccination.	Infants who are not breastfed directly from the breast; who have used analgesics in the last 48 hours before vaccination; who are agitated before vaccination; who have a history of hypersensitivity to any component of the immunobiological and/or other contraindications established by the Ministry of Health (BRASIL, 2016); or develop an allergic reaction such as a rash to the vaccine given.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:18
RBR-8kpr8cq	Postural control in children and adolescents with Autism Spectrum Disorder: Acute effect of a Horse-Assisted Therapy Session	Recruitment completed	Intervention	2022-11-04	<NULL>	<NULL>	6381	Acute effect of an Equine Therapy session on Postural Sway and Functional Mobility in children and adolescents with Autism Spectrum Disorder: a randomized controlled clinical trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-01	Departamento de Prevenção e Reabilitação em Fisioterapia	Departamento de Prevenção e Reabilitação em Fisioterapia	https://ensaiosclinicos.gov.br/rg/RBR-8kpr8cq	<NULL>	Only children and adolescents with a closed medical and/or psychological diagnosis, according to the DSM-V, will be included for the group with autistic spectrum disorder; with levels of mild or moderate impairment; able to understand and follow simple commands; who have had no previous experience, or at least in the last year, with hippotherapy; only participants whose parents have read and signed the Free and Informed Consent Term (FICT) and Assent Term (TA) will be included. For participants with typical development, only children or adolescents will be included: who do not present neurological alterations or motor disorders; participants with learning disorders, attention deficits and postural changes, certified by physicians; whose parents have read and signed the Free and Informed Consent Term (FICT) and Assent Term (TA);	In the group of participants diagnosed with autism spectrum disorder, children and adolescents will not be admitted: those with epilepsy or seizure episodes; who have had previous contact with hippotherapy in the last year; who cannot remain in semi-static orthostatic posture for at least 30 seconds; who are unable to complete the entire protocol of the present study; or whose parents and guardians do not sign the Free and Informed Consent Term (FICT) and Consent Term (TA). In the group of typical children and adolescents, participants will not be included: who have contact with horses through equestrian practice, or recreational riding; who are unable to complete the entire protocol of the present study; or whose parents and guardians do not sign the Free and Informed Consent Term (FICT) and Consent Term (TA);	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:41
RBR-10vvhwv9	The effects of Parkour Training on lower limb functionality	Recruitment completed	Intervention	2022-11-03	<NULL>	<NULL>	5696	Parkour x Plyometric Training effects on biomechanical and functional aspects of the lower limbs	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-10vvhwv9	<NULL>	Healthy volunteers; both genders; physically active; age between 18 and 30 years	Musculoskeletal pain or discomfort; unavailability of time; training frequency less than 75%	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-728v4h3	Verification of the vertical jump performance of volleyball athletes after Forced stretching of lower limbs	Not yet recruiting	Intervention	2022-11-03	<NULL>	<NULL>	5697	Verification of the acute effect of the Forced stretching of the lower limb musculature on the vertical jump height gain in volleyball athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-29	Erickson Zacharias Barboza	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-728v4h3	<NULL>	The project foresees the participation of 30 healthy participants; male; between 18 to 50 years of age; body mass index greater than 18 less than 25 kilograms per square meter; residents in the city of Florianópolis; volleyball players regularly	Will be removed who have any type of disease that prevents the vertical jump; athletes aged under 18 and over 50; athletes who have already had experience with the use of the stretching technique with proprioceptive neuromuscular facilitation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-93x9vcb	Clinical study of two root filling materials in treating a vital pulp of deciduous tooth	Data analysis completed	Intervention	2022-11-03	<NULL>	<NULL>	5699	Double-blind randomized clinical trial of the performance of two root filling materials in biopulpectmies of primay molars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-04	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-93x9vcb	<NULL>	First or second deciduous lower molar with deep caries and pulp vitality; provoked or spontaneous pain that does not relieve with the use of medication; in case of teeth with provoked pain, absence of hemostasis in adequate time up to 5 minutes, after attempted pulpotomy; absence of fistula or abscess; absence of bone rarefaction on radiographic examination; absence of internal or external resorption of more than two thirds of the root; tooth restorative possibility	Children with difficult behavior and who do not cooperate with the treatment; children who have systemic health problems; teeth with periapical lesion or interradicular bone rarefaction; internal and or external resorption involving more than one thirds of the root length; teeth with less than two thirds of the root remainder; rupture of the pericoronary sac; restorative impossibility; teeth that have had some kind of previous pulp treatment; patients using antibiotics	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-24bxqyk	Training of health managers and professionals in the state of Paraná in prevention and treatment of patient with Obesity, Diabetes and Arterial Hypertension	Recruiting	Intervention	2022-11-03	<NULL>	<NULL>	5700	Training of health managers and professionals of PHC in the state of Paraná in addressing Chronic Non-communicable Diseases: Analysis of effectiveness based on a quali-quantitative approach	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-24bxqyk	<NULL>	Be 18 years or older; both sexes; be diagnosed obesity or arterial hypertension or diabetes mellitus; be attended by a primary health care team selected to be participating in the project	Being under 18 years of age; not having a diagnosis of obesity or arterial hypertension or diabetes mellitus; not being attended by one of the primary health care teams selected to participate in the project; having a mental illness that makes it difficult to participate in the assessments provided for in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-4hrmkzz	Use of Virtual Reality associated with exercise in hospitalized patients with Heart Failure	Recruiting	Intervention	2022-11-03	<NULL>	<NULL>	5701	Use of Virtual Reality associated with exercise in hospitalized patients with Heart Failure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-25	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4hrmkzz	<NULL>	Patients with diagnosis of heart failure with left ventricular ejection fraction (LVEF) ≤ 50%, confirmed by an echocardiography examination conducted by a cardiologist; In both sexes; Older than 18 years; Hemodynamically stable: that in 48 h did not present malignant ventricular arrhythmias, ventricular extrasystoles complex, supraventricular or sinus tachycardia (greater than 120 beats per minute), 2nd or 3rd degree atrioventricular blocks and signs of low output; Have medical authorization to start rehabilitation.	Patients with cardiac arrhythmias that contraindicate physical exercises diagnosed by the cardiologist; Presence of diagnosed unstable angina; History of acute myocardial infarction for less than six months; History of cardiac surgery less than six months ago, fever within the last 48 hours with an increase in leukocytes and/or C-reactive protein seen on routine laboratory examination;  Conditions that make it difficult or impossible to use virtual reality, such as visual impairment, cognitive dysfunction, psychiatric illness, presence of neurological diseases, history of photosensitive epilepsy due to the use of video games.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-10xhkk8c	Clinical trial comparing two copaíba-based treatments for skin tears	Recruiting	Intervention	2022-11-01	<NULL>	<NULL>	5693	Double blind randomized clinical trial, comparative between treatment with Copaifera Hayne multijuga 2% and 10% in skin tears	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Hospital Universitário Clementino Fraga Filho	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-10xhkk8c	<NULL>	People with skin tears up to 5 cm² in area	People under 18 or with other wound etiologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-5wqbzx8	Assessment of cardiac measurements, blood sugar levels and psychological parameters of people with Diabetes Mellitus who practice Physical Exercise	Not yet recruiting	Intervention	2022-11-01	<NULL>	<NULL>	5694	Evaluation of cardiovascular, glycemic and psychophysiological parameters of people with Diabetes Mellitus who practice Physical Exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Instituto Mantenedor de Ensino Superior da Bahia	Centro Universitário de Excelência - UNEX	https://ensaiosclinicos.gov.br/rg/RBR-5wqbzx8	<NULL>	Volunteers with type I or type II diabetes mellitus, female or male; age between 18 to 45 years	Volunteers who have neuropathy developed by diabetes, a history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies; suffer some type of muscle injury that prevents the practice of physical exercises; individuals who during the research period fail to show up for physical tests or exercise sessions and who are not available for a new day/time to perform the procedures; who have medical restrictions for the practice of physical exercise or any type of secondary disease that may be aggravated due to participation in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-7t5nqgm	"Effect of occlusal factors on clinical performance in the restorative treatment of cervical lesions
non-carious"	Recruiting	Intervention	2022-11-01	<NULL>	<NULL>	5695	Effects of occlusal factors on the clinical performance of restorations in non-carious cervical lesion	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Pontíficia Universidade Católica do Paraná	Pontíficia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7t5nqgm	<NULL>	Good general health; good level of oral hygiene; of age (18 years); having at least two non-carious cervical lesions; presence of occlusal interference; depth of lesions of at least 1mm	Active or chronic periodontitis; bruxism and dental clenching; orthodontic treatment in progress; performance of tooth whitening during the last 6 months; pregnancy and/or lactation; endodontic treatment in the tooth with a non-carious cervical lesion; carious cervical lesion; absence of antagonist tooth in teeth with non-carious cervical lesion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-6kmdtgb	Phase II, randomized, double-blind, crossover, placebo-controlled clinical trial to evaluate the efficacy and safety of Esketamine as an adjunct to standard care in patients with Obsessive-Compulsive Disorder- OCD	Recruiting	Intervention	2022-10-31	<NULL>	<NULL>	5691	Phase II, randomized, double-blind, crossover, placebo-controlled clinical trial to evaluate the efficacy and safety of Esketamine as an adjunct to standard care in patients with Obsessive-Compulsive Disorder	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-03-01	Hospital Universitário Professor Edgard Santos	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-6kmdtgb	<NULL>	Female or male subjects, 18 to 65 years of age; Each participant must have a sufficient level of understanding to understand all procedures and the informed consent form; Participants must complete for Obsessive-Compulsive Disorder in accordance with the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, for at least one year, as assessed by a structured diagnostic interview, The Mini International Neuropsychiatric Interview, version 7.0.2, with a Yale-Brown Obsessive-Compulsive Scale score of at least 16 points ;Treatment resistance defined as at least one prior attempt at an adequate dose and duration of a serotonin reuptake inhibitor or clomipramine and/or cognitive behavioral therapy with exposure and response prevention or having refused these treatments for individual reasons;Individuals should not have changes in the dosage of selective serotonin reuptake inhibitors or clomipramine by pe least two months before enrollment in the study	Patients with severe depression defined by a Montgomery-Asberg Depression Rating Scale score greater than or equal to 34; Patients with imminent risk of suicide defined by a score greater than or equal to 4 on item 10 (suicidal thoughts) of the Montgomery-Asberg Depression Rating Scale; Use of other glutamate modulating agents; Current or past diagnosis of any psychotic disorder as defined in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders; Patients with a history of bipolar disorder as defined in the DSM-5; Individuals with a history of substance use disorder (except nicotine or caffeine) within the last 3 months according to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders; Participants who are pregnant or breastfeeding; Serious and unstable medical illnesses; History of seizures without a clear and resolved etiology; Treatment with a monoamine oxidase inhibitor within 4 weeks prior to the study; Treatment with any other concomitant medication that may interfere with the evaluation of the results and/or safety of the participant; Presence of any medical disease that may alter the morphology and/or physiology of the brain; Investigators or their immediate family members; Patients who have started cognitive behavioral therapy with exposure and response prevention in the last 8 weeks prior to study enrollment; Patients who, after randomization, need to change the standard treatment by withdrawing or adding new drugs to their treatment regimen for Obsessive Compulsive Disorder should be excluded from the study to minimize potential biases caused by differences between groups	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-66bqvm3	Scoparia dulcis (Sweet-broom) in the treatment of Diabetes	Recruiting	Intervention	2022-10-31	<NULL>	<NULL>	5692	Scoparia dulcis L. (Sweet-broom) in the treatment of Type-2 Diabetes Mellitus	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-09-01	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo	Universidade de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-66bqvm3	<NULL>	Have type-2 diabetes mellitus based on the World Health Organization criteria for at least 3 months; Poor disease control (glycosylated hemoglobin of 7-12%); regular use of antidiabetic medicines, stable doses; Age between 12 and 60 years; body-mass index &lt; 40 kg/m2; able to swallow capsules; can read	Type 1 diabetes mellitus or other specific form of diabetes; Positive test for diabetes-related autoantibodies; Monogenic diabetes; Severe diseases of the digestive system; Stressful conditions (ketoacidosis, coma, severe infection, hospital admission, or surgery) with 3 months; pregnancy or breastfeeding; allergy to S. dulcis or Plantaginaceae family; Liver failure; Chronic kidney disease stage 3g or more; Mental disease; abusive alcohol use; drug addiction; triglycerides &gt; 400 mg/dL or low-density lipoprotein cholesterol &gt; 180 mg/dL; patient request	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-6sz837s	To verify the feasibility and effectiveness of a distance Rehabilitation Program in the treatment of patients with Parkinson&apos;s Disease	Recruiting	Intervention	2022-10-30	<NULL>	<NULL>	5690	Clinical trial to verify the feasibility and effectiveness of a Mixed Remote Individual Rehabilitation Program in the treatment of patients with Parkinson&apos;s Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Bruno Lopes dos Santos Lobato	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-6sz837s	<NULL>	Patients diagnosed with idiopathic Parkinson&apos;s disease according to the London Brain Bank diagnostic criteria; Age between 30 and 80 years; Mild stage disease (Hoehn and Yahr equal to or less than 2); Use of pharmacological dopaminergic treatment at a stable dose for at least one month, with the possibility of remaining unchanged during the intervention period	Any type of atypical secondary parkinsonism; Treatment with any drug or experimental intervention in the last 90 days; Presence of severe psychotic symptoms (score greater than 2 in item 1.2 of the International Parkinson and Movement Disorders Society-Unified Parkinson&apos;s Disease Rating Scale (MDS-UPDRS); Diagnosis of dementia determined by the flowchart proposed by the Movement Disorders Society; Presence of severe systemic diseases or decompensated such as: infections, severe heart disease, malignant neoplasm, liver or kidney failure, poorly controlled diabetes; Presence of orthopedic diseases, other neurological diseases or cardiac comorbidities that prevent or pose a risk for performing aerobic or stretching exercises; Patients without access to internet at home; Patients who are unable to perform tasks on the computer, or without family assistance needed for remote activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-2mqrgk7	Omega-3 supplementation in patients with constant weight-related pain: a clinical trial	Terminated	Intervention	2022-10-28	<NULL>	<NULL>	5688	Omega-3 supplementation in patients with chronic pain related to obesity: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-03	Universidade do Sul de Santa Catarina - Unisul	Universidade do Sul de Santa Catarina - Unisul	https://ensaiosclinicos.gov.br/rg/RBR-2mqrgk7	<NULL>	Volunteer of both sexes; age between 20 and 59 years; diagnosed with obesity grade I and II; at risk of metabolic complications associated with obesity; with obesity-related chronic musculoskeletal pain; and who sign the informed consent	Volunteers using anti-inflammatory drugs (steroidal and non-steroidal) and analgesics; volunteers already taking omega-3 supplementation and volunteers who had corona virus disease 19 during the study will be excluded from the analysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-4356pb8	Effect of different doses of Weight Training on the Muscle Strength Response and Functional Capacity of untrained elderly women	Recruitment completed	Intervention	2022-10-28	<NULL>	<NULL>	5689	Effect of different doses of Resistance Training on Muscle Strength Responsiveness and Functional Capacity of untrained elderly women	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-15	Programa de Pós-Graduação em Ciências do Movimento Humano	Programa de Pós-Graduação em Ciências do Movimento Humano	https://ensaiosclinicos.gov.br/rg/RBR-4356pb8	<NULL>	Be at least 60 years old; feminine gender; present negativity in the Physical Activity Readiness Questionnaire (PAR-Q)	Male gender; volunteers who have completed Resistance Training in the previous year; present an acute or chronic condition that may compromise the execution of tests and protocols; have not completed the assessments; have not completed 8 training sessions within 6 weeks; have suffered any adverse event (injury, illness, disability...) during the training period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-479v8tv	Effect of dose fractionation of Testosterone on red blood cells in Transgender Men	Recruiting	Intervention	2022-10-27	<NULL>	<NULL>	5684	Effect of dose fractionation of Testosterone Cypionete on hematocrit in Transgender Men with Erythrocytosis secondary to testosterone use	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2022-09-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-479v8tv	<NULL>	Transgender men with and with a diagnosis of testosterone-induced erythrocytosis will be included.	Male transgender (MT) with polycythemia vera or secondary to other pathologies (chronic kidney disease, severe lung disease, chronic myeloid leukemia, lymphoma, liver diseases and Cushing&apos;s syndrome); MT using hormonal contraceptives or copper IUDs; MT with psychiatric conditions such as severe psychotic disorders, severe personality disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-5gm65y8	Physical Activity Program using Video Call in children and adolescents after Kidney Transplant	Recruiting	Intervention	2022-10-27	<NULL>	<NULL>	5685	Physical Activity Program using Telemonitoring in pediatric patients after Kidney Transplantation: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-31	Universidade Federal de Ciências da Saúde de Porto Alegre	Irmandade Santa Casa de Misericórdia de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-5gm65y8	<NULL>	Children and adolescents in the postoperative period of renal transplantation (one month to 12 months after transplantation); age between six and 18 years; both sexes; capable of performing the proposed tests and procedures; access to a digital device that allows contact by video call through the free WhatsApp® application	Children and adolescents with heart disease; myopathies; exercise-limiting neurological or orthopedic diseases; multi-organ transplant recipients; important immunosuppression that contraindicates physical exercise; cognitive difficulty in understanding and performing tests; patients who refuse to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-43hpwqk	Online Psychological Interventions to improve Well-Being - OPIW	Not yet recruiting	Intervention	2022-10-27	<NULL>	<NULL>	5686	Positive Psychology-based Interventions for Telehealth in a pandemic context: Well-being and emotional health	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-03	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-43hpwqk	<NULL>	Healthy volunteers; both genders; ages between 18 and 60 years; access to internet and a mobile device with android operating system; being a national resident in Brazil; voluntary acceptance and consent to participate in the study	Volunteers with a psychiatric diagnosis; presents mental health problem	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-556md5g	To evaluate the effectiveness of the association of an Intra-Articular Injection application and an Exercise Program in Elderly with knee Osteoarthritis: a randomized controlled clinical trial	Recruitment completed	Intervention	2022-10-27	<NULL>	<NULL>	5687	Effectiveness of previous use of Intra-Articular Corticosteroid Injection in Elderly patients with knee Osteoarthritis undergoing a Progressive Resistance Exercise Program: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-11-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-556md5g	<NULL>	Both genders; Age equal to or greater than 60 years; Diagnosis of Osteoarthritis of the knee according to American College of Rheumatology criteria (Altman et al. 2000), diagnosed by a rheumatologist; Kellgren/Lawrence radiographic classification (0-IV) between II and III (Kellgren, Lawrence, 1957); Pain between 4 and 8 centimeters on the 10 centimeter numerical pain scale in at least one knee; Symptom duration for more than 3 months; Stable medication for knee osteoarthritis in the last 3 months; Agreement and signature of the free and informed consent form for this study.	They were diagnosed with inflammatory arthritis, gout, pseudogout, fibromyalgia, psychopathies and decompensated cardiopathies or neuropathies that affected the lower limbs; Diabetes mellitus or decompensated systemic arterial hypertension; Physiotherapy or acupuncture in the last 3 months; Initiated or changed regular physical activity in the last three months; Started or changed use of walking aids in the last three months; Skin lesion that prevented intra-articular injection in the knee to be studied; intra-articular injection with corticosteroids or hyaluronic acid derivative in the studied knee in the last 3 months and in any other joint in the last month; Previous or scheduled surgery for the next 6 months; Severe clotting disorder; Suspected bacterial infection of any nature; Difficulty in locomotion and understanding/taking the tests; litigation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-285x2pv	Elastic Swaddling and General Movements	Recruiting	Intervention	2022-10-26	<NULL>	<NULL>	5683	Comparison of Swaddling-type positioning with elastic tissue and inelastic tissue in the movement of preterm newborns: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-05	Micheli Bernardone Saquetto	Hospital Inácia Pinto dos Santos	https://ensaiosclinicos.gov.br/rg/RBR-285x2pv	<NULL>	Preterm newborns admitted to the neonatal intensive care unit,  with a gestational age of less than 37 weeks; lifetime greater than or equal to 72 hours;	premature newborns using phototherapy; birth defects; peri-intraventricular hemorrhage greater than Grade II (two); diet every two hours; use of chest tube; unstable hemodynamics; risk of hip dislocation; postoperative period of thoracic and abdominal surgeries; mother with a history of illicit drug and alcohol use during pregnancy;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-109vwvmd	Can the use of Sit-stand table associated with a Personalized approach change Sedentary behaviour of overweight/obese administrative workers?	Recruitment completed	Intervention	2022-10-25	<NULL>	<NULL>	5679	Can the use of Sit-stand table associated with the Personalized approach change Sedentary behaviour in an at-risk population? A quasi-experimental study with administrative workers	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-109vwvmd	<NULL>	Do not report suffering from chronic health problems; work for a period equal to or greater than 4 hours in a sitting position; perform computer work for at least three years; have not been absent from work more than one month during the previous year, excluding the vacation period; carry out work activities in an environment that allows the installation and use of a sit-stand table for a period of six months; not be showing symptoms of the disease of COVID-19; being classified as overweight or obese through the Dual Energy X-Ray Absorptiometry (DXA) exam; agreeing to participate in the study.	Physical condition or illness preventing full participation in the study; having signs and symptoms of pregnancy or being pregnant; planning to relocate to another place of work or vacation during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-92q4qqw	Effects of Tissue Flossing and Neural Mobilization Techniques on Ankle of Adolescent Basketball Athletes	Data analysis completed	Intervention	2022-10-25	<NULL>	<NULL>	5680	The Effects of Tissue Flossing Techniques and Neural Mobilization on Ankle Range of Motion and Performance of Adolescent Basketball Athletes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-12	Universidade de Estado de Santa Catarina	Universidade de Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-92q4qqw	<NULL>	Male subjects; adolescent athletes of the Florianópolis basketball team; healthy; aged between 13 and 17 years; and with at least 6 hours of basketball training per week	Lower limb injury in the last 3 months; history of neurological or orthopedic disease that has affected lower limbs and makes them unable to perform the proposed tests; history of chronic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-55wtdr8	Evaluation of Magnesium Sulfate in Pain Relief in burn victims	Not yet recruiting	Intervention	2022-10-25	<NULL>	<NULL>	5681	Evaluation of the Analgesic Effect of Magnesium Sulfate in burn patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Fundação de Ensino e Pesquisa em Ciências da Saúde/ FEPECS/ SES/ DF	Hospital Regional da Asa Norte	https://ensaiosclinicos.gov.br/rg/RBR-55wtdr8	<NULL>	Patients admitted to the burn treatment unit who will undergo balneotherapy and dressing change; of both genders; age between 18 and 59 years; classified in physical states I and II (according to the classification of the American Society of Anesthesiology); with 10 -20% burned body surface area; with more than 24 hours and less than 72 hours of hospitalization	Readmitted patients; outpatient balneotherapy/dressing; illicit drug users; previous pain syndromes; cognitive impairment; allergic to any component of the study; psychiatric disorders; pharmacodermia; myasthenia gravis; heart disease; hypermagnesemia; pregnant women; lactating women and creatinine elevation (&gt;1.2 mg/dl)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-4rfcfgq	Effect of mental fatigue on visuomotor perfomance of martial arts athletes	Recruiting	Observational	2022-10-25	<NULL>	<NULL>	5682	Effect of prolongated cognitive effort and non-invasive brain stimulation on visuomotor perfomance of combat sports athletes	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-4rfcfgq	<NULL>	Combat sport athletes; both sexes; age between 18 and 35 years; more than five years of experience in their modality; have competitive experience in their modality of origin in the last three years; be training the modality continuously in the last six months; have an active profile on Instagram	having suffered a knockout or concussion in the last month before the beginning of the collections; being on a low-calorie diet with restricted carbohydrate intake; impossibility of data analysis due to technical failures; self-reporting cognitive and brain impairment; present visual problems that compromise color discrimination; self-reporting sleep disturbances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-378h6t6	Efficacy of combined intake of Pregabalin and Dexamethasone in preventing pain, sedation and reducing anxiety in Third Molar Surgery	Recruiting	Intervention	2022-10-24	<NULL>	<NULL>	5678	Efficacy of Pregabalin and Dexamethasone Co-administration in preemptive multimodal analgesia, sedation and anxiety reduction in Third Molar Surgeries	<NULL>	4, randomized-controlled, triple-blind	4	<NULL>	<NULL>	<NULL>	2022-04-01	Faculdade de Odontologia de Pernambuco, Universidade de Pernambuco - UPE	Faculdade de Odontologia de Pernambuco, Universidade de Pernambuco - UPE	https://ensaiosclinicos.gov.br/rg/RBR-378h6t6	<NULL>	Adult patients aged between 18 and 40 years, of both sexes, of any ethnicity, healthy, do not report reactions or allergic processes to the drugs used in the research or their components and who are not using any other medication. All patients must have both lower third molars, right and left, partially or totally included, with the same pattern of positioning and root formation, according to the Pell &amp; Gregory classification, healthy and with an indication for extraction. All patients must agree to the research and sign the Free and Informed Consent Form - TCLE	Patients with pathological lesions associated with lower third molar teeth will be excluded from the research; those who are unable to open their mouths for the surgery; patients with pericoronitis in the acute or chronic phase; recent history of head and neck chemotherapy and/or radiotherapy; use of medications that have a known interaction with pregabalin or other drugs used; smokers, pregnant or lactating patients; patients using oral contraceptives; diabetics; patients with congestive heart failure; hereditary problems of galactose intolerance; patients who do not return for postoperative follow-up within the established deadlines; those who gave up participating in the research at some point; do not perform the requested exams; have renal or liver failure; allergic to any drug used in the study; surgeries that exceed 40 minutes; present postoperative infection; and patients who do not sign the informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-9kjpp2p	Saião: an useful medicine in the treatment of Atopic Dermatitis?	Recruiting	Intervention	2022-10-24	<NULL>	<NULL>	5912	Evaluation of Kalanchoe brasiliensis cream in the Treatment of Atopic Dermatitis: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-02-15	Universidade de Ribeirão Preto - UNAERP	Universidade de Ribeirão Preto - UNAERP	https://ensaiosclinicos.gov.br/rg/RBR-9kjpp2p	<NULL>	Male or female with mild atopic dermatitis aged 18 to 70 years on at least monotherapy regimen for this disease; Present SCORAD (Scoring of Atopic Dermatitis) with a value lower than 25; Potentially fertile women will be allowed to participate in the study as long as they are using at least one form of birth control	Pregnant or breastfeeding women; Participants who during treatment need to use systemic corticosteroids and/or anti-inflammatory and/or other topical medications; Individuals with a known allergy to plants of the Crassulaceae family or components of the formula; Request, at any time, by the participant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:24
RBR-7gsnvdv	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Not yet recruiting	Intervention	2022-10-21	<NULL>	<NULL>	5677	Assessment of gynecological and dermatological acceptability of a helth product in normal conditions of use_Ave01.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-03	Avenca Indústria Cosmética Eireli -EPP	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	https://ensaiosclinicos.gov.br/rg/RBR-7gsnvdv	<NULL>	Women; age: 18 to 59 years; phototype: I to IV; whole skin of the region; occasional user of category products	Skin tags in the experimental area that interfere in the evaluation of possible reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; Atopy history; Use of vaginal cream; Participants with a history of allergy to products in the tested category; Recent gynecological surgeries; discharges; Immunodeficiency carriers; Kidney, heart or liver transplants; Active skin pathologies that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.; Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-446wxd6	Effect of lotion with grape seed oil at 5% to reduce adverse reactions caused by radiotherapy: randomized clinical trial	Recruiting	Intervention	2022-10-20	<NULL>	<NULL>	5672	Effectiveness of 5% grape seed oil lotion for radiodermatitis reduction: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Cintia da Silva Marconato	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-446wxd6	<NULL>	Female; aged 18 or over; breast cancer; indication of adjuvant or exclusive radiotherapy; with intact skin in the treatment area.	Palliative radiotherapy; history of irradiation in the same treatment field; bolus use; bilateral irradiation; allergy to lotion with grape seed oil at 5% or the non-ionic base Crodabase CR2; Uncontrolled Diabetes Mellitus; connective tissue diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-10yj42dj	Auditory neurostimulation with Brainwave Entrainment and effects on mental health	Recruitment completed	Intervention	2022-10-20	<NULL>	<NULL>	5673	Stimulation of binaural and isochronic tones in Brainwave Entrainment and its effects on the modulation of mood states and emotional well-being	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-18	Universidade Federal de Santa Catarina	Metha Ensino e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-10yj42dj	<NULL>	The research subjects will be healthy volunteers of both genders; aged 18 or over; mental illness or chemical dependency; and agreement to sign the TCLE (Free and Informed Consent Term)	Patients who have an evaluation and cut above the acceptable in the DASS-21 (Depression, Anxiety and Stress Scale) and Pittsburgh tests will be excluded from the trial; as well as those with psychosis; schizophrenia; epilepsy or a history of substance abuse; people with hearing problems and a history of therapeutic use of binaural or isochronic sounds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-1035vvfc	Effects of laser therapy in adults with fibromyalgia	Recruiting	Intervention	2022-10-20	<NULL>	<NULL>	5674	Effects of Modified Intravascular Laser Irradiation of Blood in adults with Fibromyalgia: a randomized placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-15	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-1035vvfc	<NULL>	The study will include: women with age ranging from 18 to 60 years (the age limit is set to minimize structural changes due to aging), diagnosed with fibromyalgia according to the diagnostic criteria which was set in the 2016 modification of the American College of Rheumatology (WOLFE et al. ., 2016). In general, the participants must have generalized pain in at least 4 of 5 body regions for at least 3 months, with a score of 7 on the Widespread Pain Index (WPI) questionnaire and 5 on the Severity Scale /Symptom Severity Scale (SSS), or WPI between 4 to 6 and SSS ≥ 9. In that last case, the fibromyalgia symptom scale (FS- Fibromyalgia Severity) is added, which is defined as the sum of the previous two questionnaires as a complete component of the diagnostic criteria, as presented in ANNEX I. According to UFPR‘s Normative Instruction No. 01/2021 (PRPPG/PROGRAD/PROEC), only participants who present a complete vaccination schedule or the ones who present negative results for SARS-CoV-2.0 infection in periodic examination reports of RT-qPCR or antigen type at every 72 hours will be allowed to be included in this study.	Women with cognitive deficits determined by achieving less than 13 points in the Mini-Mental State Examination will be excluded of this study (ANNEX 2) (SANTOS et al., 2010); hearing loss which prevents the understanding of verbal instructions; neurological disorders and/or trauma-orthopedic conditions that prevent the participant from carrying out the assessments and/or the proposed intervention; pregnant or lactating women; having an acute or terminal illness; presence of other pathologies at the application site; women who are undergoing physiotherapeutic treatment concomitant to the study; women who make use of steroids which which interfere with the action of ILIB; women who have modified their pharmacological treatment during the study or month prior to the intervention; women who have not taken at least the first dose of the Covid-19 vaccine; and any contraindication for the application of ILIB, namely: cardiogenic shock, arterial hypotension, heart disease, stages II and III  of circulatory failure, anemia, sick sinus syndrome, existence of blood coagulopathies (MIKHAILOV, 2009)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-6fm2x4d	Use of blood concentrates to control pain, swelling and postoperative mouth opening difficulties in mandibular wisdom teeth extractions	Not yet recruiting	Intervention	2022-10-20	<NULL>	<NULL>	5675	Use of blood concentrates in the control of pain, edema and postoperative trismus following lower third molar removal: a triple blind randomized clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-04	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-6fm2x4d	<NULL>	Will be included in the study, 28 patients aged between 18 and 30 years and without impairment of general health according to medical history (healthy) and physical examination who agree to participate in the study. Through clinical and radiographic examination, asymptomatic patients with indication for bilateral extraction of mandibular third molars will be selected, in class IIB position, according to Pell &amp; Gregory&apos;s classification.	Exclusion criteria will be considered: (I) history of use of any type of medication in the 15 days prior to the start of the surgical procedure; (II) history of hypersensitivity to drugs, substances or materials used in this experiment; (III) pregnancy or lactation; (IV) pericoronitis or other local infection within 15 days prior to the surgical procedure; (V) people with a history of systemic disease, such as hypertension, diabetes, or diseases with high oxidative stress, such as favism, severe anemia), (VI) and time of the shortest intervention less than 75% of the time elapsed in the longest intervention long.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-6y2q4d5	The use of guaranteed volume mode as a form of weaning in mechanical ventilation of premature newborns	Terminated	Observational	2022-10-20	<NULL>	<NULL>	5676	Use of the Guaranteed Volume mode as a ventilatory weaning strategy in Premature Newborns	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6y2q4d5	<NULL>	Premature newborns (gestational age equal to or less than 32 weeks), diagnosed with Respiratory Distress Syndrome and birth weight of up to 1,500g, intubated and in a weaning protocol. The protocol maintained an inspired fraction of oxygen lower than 50%, mandatory respiratory rate lower than 30 cycles per minute, peak pressure equal to or lower than 25cmH2O, and end expiratory pressure lower than or equal to 6 centimeters of water.	Using medications with side effects on the respiratory system were not included and those preterm newborns who presented clinical worsening and/or need to increase ventilatory parameters were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-4z9fcn7	Study to Evaluate Nutritional Counseling to Prevent Excessive Weight Gain During pregnancy in Pregnant Women at Instituto Fernandes Figueira Fiocruz Rio de Janeiro between 2020 and 2021	Data analysis completed	Intervention	2022-10-19	<NULL>	<NULL>	5670	A Clinical Trial to Evaluate Nutritional Counseling in Preventing Excessive Gestational Weight Gain in Pregnancy at Antenatal Care of Instituto Fernandes Figueira Rio de Janeiro between 2020 e 2021	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-29	Lizanka Paola Figueiredo Marinheiro	Instituto Fernandes Figueira- IFF Fiocruz	https://ensaiosclinicos.gov.br/rg/RBR-4z9fcn7	<NULL>	Patients over 18 years of age (complete by the day of study entry); gestational age less than or equal than 20 weeks (defined by ultrasound); Patients with BMI &gt; 18.5kg/m² singleton pregnancy	fertility assisted  pregnancy; uncontrolled hypertension; recently diagnosed thyroid disease (&lt; 30 days); history of eating disorder; bariatric surgery; mental illness;  drug or alcohol use disorder; severe gastrointestinal disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-4xyqhqm	Influence of different motors for tooth extraction of impacted wisdom teeth	Recruitment completed	Intervention	2022-10-18	<NULL>	<NULL>	5666	Influence of the use of High Electrical Rotation in Lower Third Molar Surgeries. A clinical and radiographic prospective, randomized and split-mouth study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Faculdade de Odontologia de Araçatuba – Universidade Estadual Paulista	Faculdade de Odontologia de Araçatuba – Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4xyqhqm	<NULL>	Presence of similar right and left impacted or semi-impacted lower third molars; third molars who need osteotomy and odontosection for their removal.	Presence of periodontal disease; smokers; patients with systemic alterations; patients undergoing systemic medication treatment; pregnant women; penicillin allergies; third molars extensively carious.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-6gpv7vs	Denture adhesives for Removable Partial Dentures wearers	Recruiting	Intervention	2022-10-18	<NULL>	<NULL>	5667	Impact of denture adhesives use on mastication, nutrition, and quality of life of Removable Partial Dentures wearers: Randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-30	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6gpv7vs	<NULL>	Volunteers with 40 years old or more; completely edentulous in the upper jaw and partially edentulous in the lower jaw (Kennedy class I); having only the canine and incisors teeth (from 33 to 43).	Volunteers who have a previous history of allergy to the components of denture adhesives; parafunctional habits and/or temporomandibular disorders (according to the Diagnostic Criteria of Temporomadibular Disorders); uncontrolled systemic diseases, cognitive disorders; history of neurological diseases; ischemic or hemorrhagic stroke; traumatic brain injury; Parkinson&apos;s or Alzheimer&apos;s patients; salivary flow below 0.6 mL/min; who have previously used denture adhesives in lower removable partial dentures; smokers; alcoholics will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-947n78h	Precision Oncology: chemoresistance evaluation in vitro Tumors	Recruiting	Observational	2022-10-18	<NULL>	<NULL>	5668	Precision Oncology: chemoresistance evaluation in vitro Tumors	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-10-01	Ziel Biosciences Pesquisa, Desenvolvimento e Diagnóstico LTDA	Ziel Biosciences Pesquisa, Desenvolvimento e Diagnóstico LTDA	https://ensaiosclinicos.gov.br/rg/RBR-947n78h	<NULL>	Patients of both genders diagnosed with hematological and solid neoplasms; specially breast; lung; colorectal; stomach; ovarian; melanoma and sarcoma; with indication of systemic therapy as part of their treatment or neoadjuvant therapy will be invited to participate in the study; as patients who will undergo biopsies with suspicion of neoplasia; but still without a confirmed diagnosis	Patients with benign tumors confirmed by anatomopathological evaluation will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-10tn82jt	Clinical study to detect the presence of silicone oil released by syringes used for intraocular injection	Recruiting	Intervention	2022-10-18	<NULL>	<NULL>	5669	Detection of silicone oil from the syringe in the vitreous of patients undergoing intravitreal injection: a double-blind randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Hospital de Olhos de Sergipe	SJJ Solutions	https://ensaiosclinicos.gov.br/rg/RBR-10tn82jt	<NULL>	Over 18 years of age; both sexes; diabetic retinopathy, with indication for intravitreal injection of bevacizumab; clear ocular media and adequate pupillary dilation in both eyes to allow for all imaging procedures; visual acuity between 20/25 and 20/400; provide written consent; availability to come for exam 3 days after first injection and monthly for new exams and injection for 6 months	Severe glaucoma; age-related macular degeneration or retinal dystrophy; previous or current history of uveitis; previous vitreoretinal surgery; systemic contraindication to antiangiogenic therapy; presence of intraocular inflammation; any intraocular surgery in the previous 3 months; any eye infection; pregnancy or breastfeeding; any of the following conditions: severe heart disease, significant peripheral vascular disease; stroke in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-3dgmggm	Changes in functional mobility and brain activity after Task-Oriented Intensive Treatment in children and adolescents with Cerebral Palsy	Recruiting	Intervention	2022-10-18	<NULL>	<NULL>	5773	Neural and biomechanical mechanisms associated with changes in functional mobility after an Intensive Task-Oriented Training protocol in children and adolescents with Cerebral Palsy	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3dgmggm	<NULL>	Diagnosis of cerebral palsy; ages 7 to 16 years; both genders; Gross Motor Function Classification System (GMFCS) levels I to III; who are able to understand and complete the instructions; inform consent	Uncontrollable seizures; severe visual and / or cognitive problems; children who have undergone orthopedic or neurological surgery or botulinum toxin application 6 months before or during the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:19
RBR-6b7b6tt	Evaluation of an Injectable Bioactive Restorative Material in children&apos;s molar teeth	Recruiting	Intervention	2022-10-17	<NULL>	<NULL>	5664	Evaluation of Injectable Bioactive Composite for Posterior Restoration in deciduous teeth: randomized split-mouth clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-22	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo (FORP-USP)	Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo (FORP-USP)	https://ensaiosclinicos.gov.br/rg/RBR-6b7b6tt	<NULL>	The inclusion criterion will be that the patient must be between 4 and 8 years old; and have at least 2 homologous deciduous molars with caries lesions or fractures affecting only the occlusal or occlusal-proximal surfaces	Teeth with extensive structural loss requiring indirect restorations; endodontic treatment or indication for extraction; teeth with acute painful symptoms such as pulpitis or pericementitis; teeth with structural defects such as Molar-Incisor Hypomineralisation or Amelogenesis Imperfecta; children with parafunctional habits such as child bruxism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-2x6hmbv	Consequences of Covid19 on the cardiovascular system of hypertensive patients	Not yet recruiting	Intervention	2022-10-14	<NULL>	<NULL>	5662	Consequences of Sars-Covid19 on the cardiovascular autonomic control of hypertensive patients	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-27	Faculdade de Medicina de Ribeirão Preto - FMRP/USP	Faculdade de Medicina de Ribeirão Preto - FMRP/USP	https://ensaiosclinicos.gov.br/rg/RBR-2x6hmbv	<NULL>	Homens; hipertensos ou normotensos; idade entre 35 e 55 anos; acometidos por COVID-19 entre 6 e 24 meses antes; assintomático, leve ou internados em enfermaria por baixa saturação de oxigênio	Smokers; diagnosis of cognitive disturbances, musculoskeletal disorders, and chronic diseases; during the period of transmission of the Covid-19 disease; patients who had the severe form and required ICU admission; previous home or outpatient physical therapy treatment; current use of drugs that interfere with cardiac functionality and cardiovascular autonomic control	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-3vh8zgj	Creatine supplementation plus resistance training in adults	Data analysis completed	Intervention	2022-10-14	<NULL>	<NULL>	5663	Effect of Creatine Monohydrate Supplementation in association with Strength Training with Blood Flow Restriction on strength and muscle mass gain in untrained men	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3vh8zgj	<NULL>	Male participants between eighteen and thirty years of age	Volunteers who have a body mass index below eighteen and above twenty-four; or those who, of their own free will, no longer want to participate in the study; do not attend training and collection sites on scheduled days; Have participated in strength training in the past six months; having used a food supplement or ergogenic medication for at least two years before the study; smoking or drinking alcohol at least a week before tests	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-3rqcxqd	Benefits of Morphine gel for pain reduction in patients with Cancer Wounds	Not yet recruiting	Intervention	2022-10-13	<NULL>	<NULL>	5660	Effectiveness of Topical Morphine use in patients with painful Neoplastic Wounds in the breast and head and neck: double blind randomized clinical trial - MorphineGel	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-11-01	Escola de Enfermagem Aurora de Afonso Costa	Instituto Nacional de Câncer José Alencar Gomes da Silva - Hospital do Câncer IV	https://ensaiosclinicos.gov.br/rg/RBR-3rqcxqd	<NULL>	Patient enrolled in the unit; primary or metastatic breast or head and neck disease of any histological type; malignant neoplastic wound with stage II or greater; 18 years of age or older; karnofsky performance status greater than or equal to 30%; have at least 3 on the pain intensity scale; admission time of 48 hours or more; using systemic morphine	Fistulated wound; wound with extensive coagulation necrosis (more than 50% of the wound area); wound with exudation greater than 1 (pressure ulcer scale for healing); wound with bleeding greater than 1 (validated intraoperative bleeding scale); radiotherapy in progress in the wound	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-7wjrkp9	Analysis of the foot massage effect in patients with peripheral diabetic neuropathy	Terminated	Intervention	2022-10-13	<NULL>	<NULL>	5661	"Analysis of the concern of Foot Reflexology in patients with Diabetic Neuropathy
peripheral"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Universidade do Vale do Sapucaí	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-7wjrkp9	<NULL>	clinical diagnosis of type 2 diabetes; age between 55 and 75 years; 10 years or more onset of type 2 diabetes; Body Mass Index (BMI) of less than 29.9 kg / m2; neuropathic compromises and symptoms	superior motor neuron injury; constant use of muscle relaxant; use for gait aid and orthopedic; circulatory and / or dermatological problems of the lower extremities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-4gt5jh2	Clinical Evaluation of the Survival Rate, Surface Wear and Color Stability in crowns on the teeth made of different Ceramic Materials	Recruitment completed	Intervention	2022-10-11	<NULL>	<NULL>	5657	Prospective split-mouth Clinical Study of Monolithic Zirconia and Metal-ceramic Crowns on teeth comparing Survival, Surface Wear and Color Stability	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-05	Alessandra Sayuri Tuzita	Universidade Paulista	https://ensaiosclinicos.gov.br/rg/RBR-4gt5jh2	<NULL>	Be over 18 years of age; presence of antagonist teeth, which showed differences substrates due to the difficulty of screening; mutually protected occlusion with correct curvatures of Spee and Wilson and absence of loss of vertical dimension of occlusion; and presence of adequate insertion bone.	Presence of decompensated systemic diseases; heavy smoker (more than 10 cigarettes/day); presence of severe periodontal disease; pregnant or lactating women; history of serious psychological illness.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-6x8bx3y	Management of minor illness: impact of pharmaceutical training based on clinical guidelines	Data analysis completed	Intervention	2022-10-11	<NULL>	<NULL>	5658	Pharmacy-based: elaboration, updating and implementation of clinical pharmaceutical care guidelines for self-limiting health problems	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-30	Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-6x8bx3y	<NULL>	Participants of the expert panel of the validation stage: minimum score of 5 points in multi-criteria evaluation; Pharmacists in the stages of training and use of clinical guidelines: graduation in Pharmacy; Work in Community Pharmacy; Patients who evaluated pharmaceutical care: having a self-limiting health problem in one of the themes of the clinical guidelines; Be over 18 years old	Participants who are not available to participate will be excluded from the project; Be under 18 years of age; Fail to respond to contacts established by researchers after 3 consecutive attempts, made 3 business days apart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-794593r	The Effect of Alzheimer&apos;s Disease Education Associated with Meditation on Family Caregivers&apos; Stress and Quality of Life	Recruitment completed	Intervention	2022-10-11	<NULL>	<NULL>	5659	Efficacy of Psychoeducation associated with Meditation on Burden and Quality of Life of Family Caregivers of Patients with Alzheimer&apos;s Disease	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Instituto Israelita de Ensino e Pesquisa Albert Einstein	Instituto Israelita de Ensino e Pesquisa Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-794593r	<NULL>	Volunteer directly responsible for the care of the elderly person with dementia; not receiving remuneration for care; dedicated to care for at least three months; dedicated to care for at least 8 hours a day	Volunteers under the age of 18; patients with severe chronic diseases; experienced meditators; having a family member participating in the research; caring for elderly people with a questionable dementia diagnosis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-106frtzv	Effects of the use of a mobile application in women with complaints of stress urinary incontinence	Recruiting	Intervention	2022-10-10	<NULL>	<NULL>	5655	Effects of using a mobile application in female pelvic training in women complaining of stress urinary incontinence: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-106frtzv	<NULL>	Women with symptoms of stress urinary incontinence and/or mixed; aged over 18; literate; with preserved cognitive ability; with access to the internet; who have a mobile device with Android system; with understanding of the functioning of the application developed by the team of researchers.	Women who have symptoms of urinary incontinence only emergencies; pregnant women; puerperal women, with urinary tract infection; with presence of bone deformities and muscular dysfunctions; with neurological impairment that cause urinary incontinence; which underwent treatment and/or previous training of the pelvic floor muscles.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-107w28wf	The use of an intermediate flowable base in restorations of endodontically treated premolars	Not yet recruiting	Intervention	2022-10-10	<NULL>	<NULL>	5656	Clinical evaluation of posterior composite restorations placed with an intermediate flowable base in endodontically treated premolars	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-20	Pontificia Universidade Católica de Paraná	Pontificia Universidade Católica de Paraná	https://ensaiosclinicos.gov.br/rg/RBR-107w28wf	<NULL>	Adult patients who underwent endodontic treatment in the past 30 days and currently have a temporary restoration in upper premolars. The teeth should have at least the buccal and lingual walls remaining and occlusal contacts in the teeth included in the study	Patients with teeth in need of indirect restorations due to significant loss of tooth structure, parafunctional habits, absence of the antagonist teeth, tooth mobility, and periodontally compromised condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-6z857dk	Nursing Intervention in the Glycemic Control of the Elderly	Not yet recruiting	Intervention	2022-10-07	<NULL>	<NULL>	5654	Evaluation of the effectiveness of a nursing intervention based on the Theory of Dorothea Orem&apos;s self-care deficit in the glycemic control of elderly people with type 2 diabetes mellitus: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-01-01	Universidade de Brasília	Secretaria de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-6z857dk	<NULL>	Age over 60 years; have at least six months and a maximum of 10 years of diagnosis of type 2 diabetes mellitus to be confirmed in the electronic medical record; be registered at the basic health unit; have a cell phone with access to an instant messaging application; have long availability to attend the study; and be able to understand, verbalize and respond to proposed questions.	Diagnosis of type 1 diabetes mellitus; being insulin dependent; having chronic complications of diabetes mellitus (nephropathy, retinopathy, limb amputation and diabetic foot); have mobility limitations; and not knowing how to read and write.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-36w6cbr	Effect of task training on prevention of arm contracture in subjects after Stroke – a feasibility study	Not yet recruiting	Intervention	2022-10-06	<NULL>	<NULL>	5652	Effect of task-specific training in the prevention of upper limb contracture in individuals after Stroke- a feasibility study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-15	Universidade Federal de Minas Gerais	Hospital Risoleta Tolentino Neves	https://ensaiosclinicos.gov.br/rg/RBR-36w6cbr	<NULL>	Individuals aged 18 years or older; clinical diagnosis of stroke (first episode); presence of lacunar infarction; be within the period of up to 10 days after stroke; unilateral clinical signs (hemiparesis with muscle weakness of the upper limb greater than or equal to 10%, confirmed by the average of three measurements of handgrip strength performed with a dynamometer); ability to respond to simple commands, such as “put your hand on your head” and “raise your arm” performed with the non-paretic limb; and who reside in the metropolitan region of Belo Horizonte.	Presence of orthopedic conditions in the upper limbs or others that prevent measurement proposed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-3fztgp8	Influence of Laser on the salivary glands of individuals with Sjögren&apos;s Syndrome and the relationship of oral health to quality of life	Recruitment completed	Intervention	2022-10-06	<NULL>	<NULL>	5653	Influence of Low Power Laser Therapy on salivary glands of individuals with Sjögren&apos;s Syndrome and the impact of oral health on quality of life	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-08	Universidade de São Paulo	Faculdade de Odontologia de Bauru	https://ensaiosclinicos.gov.br/rg/RBR-3fztgp8	<NULL>	Individuals over 18 years of age; of both genders; who are under dental follow-up at the Bauru Dental School (FOB/USP) in the Stomatology Clinic; with a definitive diagnosis of Sjogren&apos;s Syndrome; and salivary flow test results corresponding to hyposalivation or low salivary flow	Individuals under 18 years of age; with other diagnoses not consistent with Sjogren&apos;s Syndrome; and who have normal salivary flow after salivary flow testing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-9pbq9fg	Effects of resistance training on Fibromyalgia	Recruiting	Intervention	2022-10-06	<NULL>	<NULL>	7085	Effects of the progressive intensity resistance training on Fibromyalgia impact: a blinded randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-01	Universidade Federal de São Carlos (UFSCar)	Universidade Federal de São Carlos (UFSCar)	https://ensaiosclinicos.gov.br/rg/RBR-9pbq9fg	<NULL>	Male and female patients; aged between 20 and 55; diagnosis of fibromyalgia based on the recommendations of the American College of Rheumatology	Neurological conditions that interfere with assessments; joint diseases at advanced levels; suspected thrombosis; heart disease; pregnancy; abuse of alcohol and illicit substances; active cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-89z5hb7	Effect of the medication buspirone hydrochloride on teeth grinding as a side effect of anxiety: a previous study	Not yet recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5648	Effect of buspirone hydrochloride on awake bruxism as a somatic manifestation of anxiety: a pilot study	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2022-11-30	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-89z5hb7	<NULL>	female volunteers, over 18 years old, diagnosed with definitive awake bruxism	participants who do not agree to participate in this study or who have some cognitive difficulty that prevents them from answering the questionnaires; under 18 years old; individuals with epilepsy; with acute intoxication and/or chronic use of alcohol, hypnotics, analgesics, or antipsychotic drugs; with severe kidney and liver failure; history of seizure; current illness or history of serious neurological or psychiatric disorders; history of chronic musculoskeletal pain; previous diagnosis or signs and symptoms of other chronic temporomandibular disorders; use of prescription drugs or drugs with possible effects on sleep or changes in motor behavior or drug interactions with buspirone hydrochloride; smoking; currently undergoing medical or dental treatment; with some dental characteristics, such as loss of more than two posterior teeth, except third molars and users of complete dentures, removable partial dentures and orthodontic appliances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-5cjpz86	Effectiveness of hot tub bath in pain of hospitalized children	Not yet recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5649	Effectiveness of hot immersion bath in pain management of hospitalized children: Randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Escola de Enfermagem da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5cjpz86	<NULL>	Children who meet the following criteria will be included in the study: Children between 28 days and 2 years old, hospitalized in the Pediatric Inpatient Unit/Ward for respiratory problems; Children with pain, evaluated by validated scales: Neonatal Infant Pain Scale (NIPS), whether it is: severe, moderate or mild pain; or Face, Legs, Activity, Cry, Consolability (FLACC), be it: severe, moderate or mild pain; Have the permission of their parents or guardians to participate in this study. In addition to these criteria, the inclusion of the same child within 12 hours of the last inclusion in the study will also be allowed if the child is not under the influence of pain management medications and the last medication for this purpose was taken within 6 hours, considering the time of action of the most used drugs.	Exclusion criteria will be: Children over 2 years of age; Children using positive pressure ventilation (CPAP); Children awaiting transfer to the Intensive Care Unit (ICU) due to worsening respiratory distress, since the immersion bath can cause crying and irritability and the condition worsens; Children who have taken any medication for pain management within 6 hours of pain detection using the validated scales; Children with a previous diagnosis of chronic pain. It is worth mentioning that there are medications that are used both for pain management and for other conditions, for example dipyrone, which in addition to being an analgesic also has antipyretic properties, and can be used in the management of fever. Thus, the researcher at the time of collection will pay attention to the medications that were previously administered to the child and whether they have analgesic properties, in order to avoid inclusion bias. If they also act in pain management, the medication must have been administered within a 6-hour interval prior to the moment of pain detection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-6pq5f74	Effects of a Physical and Cognitive Exercises program in community-dwelling elderly gait	Not yet recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5650	Effects of a dual-task Exercises Program in community-dwelling elderly gait	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Universidade Federal de Ciências da Saúde de Porto Alegre	Secretaria Municipal de Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-6pq5f74	<NULL>	60 years of age or older; live in Porto Alegre; be available to participate in the program on the days and times established; be physically independent	To have physical limitations that make it impossible to perform the proposed exercises; having uncontrolled chronic diseases; disabling pain	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-7bvrzp7	Effect of Pilates compared to Pelvic Floor Muscle Training on urinary incontinence, pelvic floor muscle strength and respiratory in elderly women: a randomized clinical trial	Recruiting	Intervention	2022-10-05	<NULL>	<NULL>	5651	Assessment and intervention through Physical Activity and Physical Therapy in elderly women with and without pelvic floor dysfunction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-7bvrzp7	<NULL>	Being female; being between 60 – 79 years of age; presence of voluntary contraction of the pelvic floor muscles at least grade 2 defined as weak perineal contraction weak contraction on palpation; preserved cognitive function verified by the Mini Mental State Examination (MMSE) scored according to education level	Are currently or recently (less than 6 months) undergoing physical therapy intervention for symptoms of urinary loss and/or are practicing another modality of physical activity with the exception of walking; presence of urge urinary incontinence due to neurological causes or self-reported urinary tract infection; smoking habits; chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD); asthma; bronchitis; occupational lung diseases and pulmonary hypertension; presence of diseases that constitute contraindications for the performance of Mat Pilates exercises; such as decompensated arterial hypertension; advanced arthrosis; fibromyalgia and surgeries; recent ligament fractures or rupture; advanced disc protrusion and advanced postural deviations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-9vv5rsw	Effect of laser on Diabetic Foot: randomized clinical trial	Recruiting	Intervention	2022-10-04	<NULL>	<NULL>	5646	Effectiveness of Laser therapy in Diabetic Foot: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-06	Faculdade de Enfermagem - Universidade Estadual de Campinas	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-9vv5rsw	<NULL>	Participants with diabetes mellitus; both genders; aged 18 or over; foot wound	Lupus; pyoderma gangrenosum; Steve Johnson Syndrome.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-4xnvx8b	Grape Seed Meal Supplementation on Women with Metabolic Disorders	Recruiting	Intervention	2022-10-04	<NULL>	<NULL>	5647	Effects of 12-week supplementation of Grape seed meal on Insulin resistance in women with Polycystic ovarian syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de São Paulo (UNIFESP)	Universidade Federal de São Paulo (UNIFESP)	https://ensaiosclinicos.gov.br/rg/RBR-4xnvx8b	<NULL>	Women with Polycystic ovary syndrome (Rotterdam); age between 19 and 45 years; BMI &gt; 18.5 kg/m2 and &lt; 35 kg/m2 and using contraceptive pill.	Women who regularly consume supplements rich in antioxidants, polyphenols, or dietary fiber; metformin; pregnant or nursing women; regular practitioner of vigorous physical activity exceeding 120 minutes per week; known contraindication to the supplement or placebo; insulin-dependent, smoking; recent history (&lt; 3 months) of alcohol or licit/illicit drug abuse; hyperandrogen disorders; and co-presence of other clinically relevant diseases (kidney disease, liver disease, tuberculosis, HIV, and cancer).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-6fgnsqr	Electrical Brain Stimulation and its benefits for Chronic Kidney Patients on Hemodialysis	Data analysis completed	Intervention	2022-10-04	<NULL>	<NULL>	6034	Transcranial Direct Current Stimulation and its therapeutic potential in patients with Chronic Kidney Disease in Hemodialysis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-6fgnsqr	<NULL>	Age between 18 and 75 years; previous medical evaluation with clinical diagnosis of depression; anxiety; chronic pain and pressure lability and being on hemodialysis treatment	Evidence of any cognitive deficit (senile dementia, Alzheimer&apos;s); presence of physical and / or organic difficulties; individuals with severe cardiovascular risk or hemodynamically unstable; history of seizures or epileptic disease; pregnancy; metallic implants in the head or neck and cardiac pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:28
RBR-3g655ht	Infant motor profile: portuguese translation and data of Brazilian population	Not yet recruiting	Observational	2022-10-03	<NULL>	<NULL>	5645	Infant motor profile: portuguese translation and normative data	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-11-30	Eloisa Tudella	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-3g655ht	<NULL>	Brazilian infants. Both genders. Chronological age between 3 and 18 months old. Infants whose parents or legal guardians consent to participation by signing the Free Consent and Clarified Term.	Infants whose parents and legal guardians cannot understand the Free Consent and Clarified Term and the Portuguese language.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-9d5kyq4	The effects of a group sports intervention for children and adolescents with autism spectrum disorder	Recruiting	Intervention	2022-10-03	<NULL>	<NULL>	5767	Effectiveness of sports stars Brazil on activity, participation and physical literacy in children and adolescents with autism spectrum disorder : a randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-12-10	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-9d5kyq4	<NULL>	Age between 6 and 18 years at the beginning of the intervention; Diagnosis of autism spectrum disorder, classified as mild to moderate on the Childhood Autism Rating Scale; Classified by level I and II Autism Classification System of Functioning: Social Communication	Have cognitive, behavioral, or clinical limitations (cardiorespiratory disease) that prevent them from following instructions and safely participating in physical activity in a group setting	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-62f6qwh	The effects os the Dental Treatment for the patients with Head and Neck Cancer	Data analysis completed	Intervention	2022-10-03	<NULL>	<NULL>	7892	The Odontological Treatment on the Head and Neck Cancer patient	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-04	Faculdade de Odontologia da Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-62f6qwh	<NULL>	Presence of tumors in the oral cavity that needed radiotherapy, with or without chemotherapy; age higher than 18 years old; and presence of at least 6 natural teeth, excluding third molars	Patients previously submitted to radiotherapy or chemotherapy; patients on non-oral feeding ways; patients using antiresorptive drugs; and patients that received dental treatment in the past 6 months before the first observational period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:36
RBR-7wgtqnz	Effects of use with crocheted Octopus or Swaddled on the Sleep Quality of Premature Newborns	Recruitment completed	Intervention	2022-09-30	<NULL>	<NULL>	5643	Effects of positioning with the Octopus or Swaddled on the sleep of Very Low Birth Weight Newborns	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade federal do Rio Grande do Norte	Universidade federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7wgtqnz	<NULL>	Premature newborns who present weight of birth greater than 1500 grams; with APGAR ≥ 5 in the fifth minute; no evidence of perinatal asphyxia or neurological disease; absence of maternal drugs and antiepileptics drugs or antidepressants during the last month of pregnancy; absence of child use of a drug antiepileptic or analgesic in the last 24 hours; no malformations; clinically stable; in room air	Need treatment with theophylline, sedatives, muscle relaxants or analgesic medications; return for respiratory support or oxygen therapy; discharge before the evaluation of the second method	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-8s5vqbb	Clinical evaluation of Resin Restorations in teeth with abfraction	Not yet recruiting	Intervention	2022-09-30	<NULL>	<NULL>	5644	Clinical evaluation of direct Adhesive composite resin Restorations in abfraction dental lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-08	Universidade do Estado do Rio Grande do Norte	Faculdade de Enfermagem e Medicina Nova Esperança	https://ensaiosclinicos.gov.br/rg/RBR-8s5vqbb	<NULL>	Patients of both biological sexes; age between 18 and 50 years; good general health and satisfactory oral hygiene; with at least 20 teeth; with dental retainer; diagnosis of at least two abfraction lesions with at least 1 mm of depth, in different premolars located in different hemi-arches, in occlusion and which have opposing teeth; sound premolars or with satisfactory restorations in an area different from the abfraction lesion; no nearby gingival inflammation or periapical changes	Patients in need of use of dental prosthesis with the edentulous space adjacent to the dental elements that could be included in the research; caries diagnosis coinciding with the abfraction lesion or endodontic treatment indication; diagnosis of severe parafunctional habits; presence of moderate or severe periodontal involvement	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-7kh27st	Cognitive-Evolutionary Group Therapy	Not yet recruiting	Intervention	2022-09-29	<NULL>	<NULL>	5641	Efficacy of Cognitive-Evolutionary Group Therapy for Depression: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-15	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-7kh27st	<NULL>	Aged at least 18 years old; have mild or moderate depression, expressed as a score of at least 9 to 20 on the Patient Health Questionnaire-9 (PHQ-9), without suicide risk evaluated by the Structured Clinical Interview for DSM-5 (SCID-5); have Internet at home and a computer or any electronic device connected to the Internet in order to access the free platform of Google meet; filled out the mandatory inform consent.	Having hypothyroidism due to being a cause of organic depression related to hormone levels; having suicide risk evaluated by the Structured Clinical Interview for DSM-5 (SCID-5); having severe depression (score &lt; 20 or more on the PHQ-9); having a medical disorder that would interfere to participating; having substance abuse (alcohol and others drugs), psychosis, anxiety or panic disorder out of context of depression, personality disorders (obsessive-compulsive and borderline disorder); bipolar disorder; be under psychological treatment by the time of the recruiting.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-3wk8m73	Mental fatigue and activities of daily living	Recruiting	Intervention	2022-09-29	<NULL>	<NULL>	5642	Effect of mental fatigue on elderly performance in tasks of daily living	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-15	Programa de Pós-Graduação em Gerontologia da Universidade Estadual de Campinas (UNICAMP)	Programa de Pós-Graduação em Gerontologia da Universidade Estadual de Campinas (UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-3wk8m73	<NULL>	Older adults (≥ 60 years old); both sexes; literate; living in the metropolitan area of Campinas-SP; use smartphone to access social media, such as Facebook, Instagram, Twitter and WhatsApp	Older adults with cognitive impairment; physical dependence in activities of daily living	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-10kpgx78	A package of social media material targeting low back pain beliefs in the general community: a randomized controlled trial.	Not yet recruiting	Intervention	2022-09-28	<NULL>	<NULL>	5640	Effect of a digital pain education material on beliefs and attitudes about low back pain in the general community: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10kpgx78	<NULL>	Adults residing in Brazil; aged 18 years old or over; able to speak Portuguese; know how to read and understand reading in the Portuguese language; have access to the internet.	Not applicable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-3fn3p3r	Evaluation of Therapies with Dogs and with Lights in the control of children&apos;s anxiety in the Treatment with Dentists	Recruitment completed	Intervention	2022-09-26	<NULL>	<NULL>	5638	Evaluation of Dog-Assisted Therapy and Intravascular Irradiation of Blood with Laser (ILIB) in the control of children&apos;s anxiety in Dental Treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3fn3p3r	<NULL>	Children who do not use anxiolytics; children who have levels of anxiety and/or fear of dental procedures; children from the children&apos;s clinic at the PUC-Campinas School of Dentistry; patients or guardians who agree to participate in the research by signing the Free and Informed Consent Term and the Assent Term; children who will undergo anxiety-generating procedures, such as anesthesia, dentistry, surgery and/or endodontics	Patients allergic to dogs; patients who have a phobia and/or fear of dogs; patients or guardians who do not agree to participate in the research and have not signed the Term of Free and Informed Consent and the Term of Assent; children who were using medications that alter the central nervous system, such as anxiolytics, antidepressants and muscle relaxants; adult patients; children with psychological or psychiatric problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-53643h8	Effect of Hygiene Devices on the healing of Inflammation around dental implants	Not yet recruiting	Intervention	2022-09-26	<NULL>	<NULL>	5639	Effect of Hygiene Devices on the healing of Peri-implant Mucositis lesions: a parallel randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-53643h8	<NULL>	Age greater than or equal to eighteen years; Implants in function for more than a year; Diagnosis of peri-implant mucositis, defined as: Presence of visual signs of peri-implant inflammation combined with profuse bleeding on probing (line or drop) and/or suppuration at two or more sites, probing depths of four to five mm and no detectable bone loss	Absence of adjacent teeth; No contact point with adjacent teeth; Implants diagnosed with peri-implantitis; Patients in which the Curaprox IAP Probe cannot be used due to lack of space; Full-arch or removable implant-supported rehabilitation; Fixed implant-supported rehabilitation (multiple prosthesis); Implants with inadequate hygiene access or marginal misfit; Individuals with limited manual dexterity, making self-administered implant hygiene impossible; Presence of active periodontal disease; Heavy smokers; Patients with transmissible diseases or critical medical conditions such as, but not limited to: uncontrolled diabetes, AIDS, bone disease and rheumatic fever; Conditions requiring prophylactic antibiotic coverage prior to dental treatment; Pregnancy or breastfeed; Any known allergies to the components of the supplied products	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-102bc3f2	Effects of Nitrate-rich food intake in elderly individuals	Recruitment completed	Intervention	2022-09-26	<NULL>	<NULL>	7864	Effects of Nitrate-rich food consumption on physical capacity, cognitive function, mood state, and anti-inflammatory and antioxidant potential in active and sedentary older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-06-01	Faculdade de Ciências da Saúde da Universidade de Brasília	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-102bc3f2	<NULL>	Elderly who live in Brasilia; age between 60 and 75 years old; both sexes; elderly who accept to participate in the study	Elderly with excessive ingestion of alcoholic beverages; smokers; who use drugs that can block the reduction of nitrate and nitrite to nitric oxide (sexual hormones, antacids, proton pump inhibitors, xanthine oxidase inhibitors); drugs that can enhance nitric oxide effects (phosphodiesterase inhibitors); treatment with anticoagulants and immunosuppressive drugs; elderly who can not exercise; with malignant diseases; vegetarian; who do not like or who are advised to not consume green vegetables; who use mouthwashs; who use antibiotics until 7 days before the beginning of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:16
RBR-10m7c788	Effect of Platelet-Rich Fibrin on the stability of Bone Graft and soft tissues around dental implants: a randomized clinical trial	Not yet recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5631	Guided Bone Regeneration in the maxilla with the use of Xenogeneic Graft associated or not with Platelet-Rich Fibrin: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Faculdade Paulo Picanço	Faculdade Paulo Picanço	https://ensaiosclinicos.gov.br/rg/RBR-10m7c788	<NULL>	Volunteers aged between 20 and 80 years; both genders	Partially dentate volunteers; with jaws without adequate bone height; uncontrolled systemic disease; smokers; history of radiation in the treatment area	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-6m8bnbz	Impact of the Physiotherapy on disability and fear of elderly people with low back pain	Recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5632	Impact of the Psychological Informed Physiotherapy on disability, fear and self-efficacy of elderly people with chronic low back pain	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-08-30	Universidade do Vale do Rio dos Sinos	Universidade do Vale do Rio dos Sinos	https://ensaiosclinicos.gov.br/rg/RBR-6m8bnbz	<NULL>	Volunteers with a main complaint of chronic low back pain; internet access and electronic device that allows video calling	Volunteers who have orofacial, visceral, radiating or cancer-related pain; surgery or fracture in plaster in the previous 6 months; medical diagnosis of diseases such as Parkinson&apos;s, Multiple or Amyotrophic Lateral Sclerosis and Fibromyalgia; unexplained weight loss greater than 5 kilograms in 2 weeks; fever; who are receiving another physical therapy follow-up	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-2xwgc74	Evaluation of saliva and plasma metabolites associated with Periodontitis in obese and normal weight pregnant women and saliva proteins of these women during pregnancy and after delivery	Data analysis completed	Observational	2022-09-23	<NULL>	<NULL>	5633	Evaluation of the metabolic profile of saliva and plasma associated with Periodontitis in obese and eutrophic pregnant women and of proteins differentially expressed in the saliva of these women in pre and post term	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-07	Faculdade de Odontologia de Bauru - Universidade de São Paulo	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2xwgc74	<NULL>	Pregnant women aged 18–40 years; who were in the 3rd trimester of pregnancy, between 27th and 39th gestational weeks; with regular follow-up with the obstetrician; and who had adequate cognitive function during pregnancy, without impairments that required absolute rest	Twin pregnancy; individuals with neuromotor impairment; arterial hypertension during pregnancy; Gestational Diabetes Mellitus; malnutrition; overweight, therefore, BMI between 25.00 and 29.99 kg/m2; confirmed or suspected diagnosis of SARS-CoV-2 infection; with hyposalivation; subjects who were using or who used at some point in pregnancy antibiotics or any medication that could interfere with periodontal status and/or salivary flow, e.g., immunosuppressive, anticonvulsant or calcium channel-blocking drugs, such as cyclosporine, phenytoin or nifedipine, respectively; who were under orthodontic treatment or any dental treatment with another professional; participants with cavitated caries lesions; with severe dental wear; with diagnosis of stages I and IV of periodontitis; with multiple tooth loss, being more than two teeth per hemiarch; with self-reported systemic disease besides obesity; and users of alcohol, tobacco, or illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-10m378rj	Ultrasound guided knee nerve block for Chronic Pain management due to Osteoarthritis	Recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5634	Ultrasound-guided Chemical Neurolysis of genicular nerves to treat Chronic Pain from primary knee Osteoarthritis	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-05-01	Mariana Gonçalves Musauer	Instituto Nacional de Traumatologia e Ortopedia	https://ensaiosclinicos.gov.br/rg/RBR-10m378rj	<NULL>	Over 18 years of age; gender both; diagnosis of primary knee osteoarthritis grades II to IV by the Ahlbäck classification modified by Keyes and Goodfellow; moderate to severe pain in the affected knee measured by the visual analogue scale; surgical indication for total knee arthroplasty; waiting list for surgery at the National Institute of Traumatology and Orthopedics (INTO)	BMI&gt;35; presence of severe pain from osteoarthritis in another joint; previous knee surgery indicated for the procedure; interventional procedure less than 1 year ago; clinical signs or history of trauma or infection; presence of neuropathic knee pain; presence of severe or moderate mood disorders without prior treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-88hrnnw	Effect of Rosemary on sleep, mood status and cardiovascular risk in emergency nursing: intervention study	Not yet recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5635	Effectiveness of Rosemary on sleep, affectivity and cardiovascular risk in emergency nursing: a quasi-experimental study	<NULL>	2-3, n/a, open	2-3	<NULL>	<NULL>	<NULL>	2022-10-03	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-88hrnnw	<NULL>	Nursing assistants; nursing technicians; nurses; work in emergency services (emergency care unit and hospital emergency department) for at least one month; aged 30 years or older; under any form of contract	Hypersensitivity to Rosemary; pregnant women; lactating women; epileptics; dyslipidemia treatment; diabetes mellitus treatment; biliary or hepatic dysfunction; prostatic diseases; gastroenteritis; those with hair &lt; 2 cm in the region of the posterior vortex of the head; use of topical medication on the scalp; or away from work for any reason during the data collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-46cmrsb	Effects of Elastic Tape on the activity of the masseter muscle, facial pain and jaw movement	Recruiting	Intervention	2022-09-23	<NULL>	<NULL>	5636	Effects of Kinesiology Tape on electrical activity of the masseter muscle, orofacial pain and mandibular mobility	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-06	Faculdade de Medicina da Universidade Federal de Minas Gerais	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-46cmrsb	<NULL>	Age between 18 and 35 years of age; have orofacial pain; sign the Free and Informed Consent Form	History of allergies to the use of bandages; facial malformation; neurological alteration; neurodegenerative disease; skin lesion in the area where the bandage will be applied; using analgesics, muscle relaxants, antidepressants or anti-inflammatory drugs; gluten intolerance; not performing the requested activities; removing the bandage before the stipulated time; not attending any of the evaluations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-776skr9	Flourishing/Florescer Program	Recruitment completed	Intervention	2022-09-23	<NULL>	<NULL>	7648	Development and evaluation of a positive psychology based intervention: Flourishing/Florescer Program	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-27	Faculdade de Medicina da Universidade de São Paulo - FMUSP	Faculdade de Medicina da Universidade de São Paulo - FMUSP	https://ensaiosclinicos.gov.br/rg/RBR-776skr9	<NULL>	Eligible participants are adults between 18 and 59 years of age; who have mild to moderate depressive symptoms; both genders	Will be excluded individuals who score above the cutoff of 20 points in the PHQ-9 screening for depressive symptoms; individuals who have previous diagnoses of psychiatric disorders presented by a psychiatrist; individuals with incomplete elementary education; individuals who do not reside in Sao Paulo city; individuals who do not have access to the internet; individuals who present more than two absences during the program sessions, and individuals who refuse to continue in the program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-52pndym	Analysis of the effects of Physical Therapy and Low-Level Laser on the improvement of symptoms during drug treatment of Leprosy	Recruiting	Intervention	2022-09-22	<NULL>	<NULL>	5624	Application of Conventional Physiotherapy associated with Phototherapy for the treatment of Leprosy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Mato Grosso	Secretaria Municipal de Saude de Varzea Grande	https://ensaiosclinicos.gov.br/rg/RBR-52pndym	<NULL>	Patients diagnosed with leprosy; of both sexes; aged 18 years or older; using corticosteroids	Patients who do not use the medication as determined by the physician; individuals who do not attend the outpatient clinic for phototherapy and patients with Diabetes Mellitus and peripheral neuropathies resulting from other pathologies	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-35n9nkj	Effect of Auriculotherapy on Anxiety in adults within the Basic Health Unit	Recruitment completed	Intervention	2022-09-22	<NULL>	<NULL>	5625	Effect of Auriculotherapy on Anxiety in adults in Primary Care: pilot clinical trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-05-02	Universidade do Sul de Santa Catarina	Unidade Básica de Saúde Central do Município de Palhoça	https://ensaiosclinicos.gov.br/rg/RBR-35n9nkj	<NULL>	Over 18 years old; both sexes; medium and high anxiety level	Users who are being treated with the following drugs: psychotropic drugs, antibiotics, corticosteroids and anabolics; pregnant women in the first trimester of pregnancy; illiterate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-7fr89pt	The effect of an intervention program based on Education in patients with Chronic Low Back Pain	Recruitment completed	Intervention	2022-09-22	<NULL>	<NULL>	5626	The effect of a Pain Education-based Intervention Program on pain intensity, function and psychosocial outcomes in patients with Chronic Low Back Pain: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-18	Hospital Universitário da Universidade Federal de Juiz de Fora	Hospital Universitário da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-7fr89pt	<NULL>	This study will include individuals of both sexes, aged between 18 and 65 years, with chronic low back pain for at least four months. To ensure that a minimally relevant clinical difference (DCMR) is detected, minimum clinical severity indices have been determined so that participants are included.	Exclusion criteria: Individuals with cancer pain, recent fracture history, rheumatic diseases, chronic painful syndromes (with fibromyalgia or chronic fatigue syndrome), postoperative period of musculoskeletal diseases in the last 12 months, headache, epilepsy will not be included in association with chronic low back pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-4s35wkz	The Effect of Blue and Red LED Lights on Pimples on the Face	Recruiting	Intervention	2022-09-22	<NULL>	<NULL>	5628	Effect of Blue and Red LEDs on Inflammatory Acne : controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-09	Universidade Nove de Julho - UNINOVE	Universidade Nove de Julho - UNINOVE	https://ensaiosclinicos.gov.br/rg/RBR-4s35wkz	<NULL>	People aged 12 to 25 years of either sex who have inflammatory acne grades 2 and 3.People who do not have any disease that interferes with the worsening of acne. During the anamnesis if there is any disease the pictures will be discussed with the dermatologist.	People with Fitzpatrick rating scale V and VI due to risk of post-inflammatory hyperpigmentation; People who have used oral medications such as isotretinoin in the last six months or antibiotics for acne in the last 3 months or who are using hormones;Pregnant or lactating women;Women using contraceptives;People who have used cosmetic acne treatments such as lasers and medium to deep peels in the last 3 months.People allergic to salicylic acid	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-25s7pvd	Effects of Resistance Training and the menstrual cycle on muscle mass	Recruitment completed	Intervention	2022-09-22	<NULL>	<NULL>	5629	Effects of Resistance Training and menstrual cycle phase on muscle mass	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-07	Universidade Federal de São Carlos	Laboratório de Adaptações Neuromusculares	https://ensaiosclinicos.gov.br/rg/RBR-25s7pvd	<NULL>	Healthy younger women; age between 18 and 35 years; regular menstrual cycle lasting 21 to 35 days	Regular practice of physical activities; irregular menstrual cycles; anovulatory cycles; cycles with luteal deficiency; any kind of hormonal treatment; endocrine disorders or disorders involving the menstrual cycle; any injury that prevents the practice of physical activity; treatment with drugs that alter body composition	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-5jhgkz4	Intrastromal Keraring Corneal Ring Study for Keratoconus Corneal Disease	Recruiting	Observational	2022-09-22	<NULL>	<NULL>	5630	Keraring Intrastromal Corneal Ring PMCF Study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-01	Logos Saúde Ltda	Logos Saúde Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5jhgkz4	<NULL>	Patient with keratoconus; both sexes; any age; patients who have Keraring implanted in the eye	Patients who do not have Keraring implanted in the eye	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:14
RBR-53gfpy9	Evaluation of Bone Loss around teeth in radiographs of children and adolescents treated at Piracicaba Dental School	Not yet recruiting	Observational	2022-09-21	<NULL>	<NULL>	5619	Evaluation of Radiographic Bone Loss in children and adolescents treated at Piracicaba Dental School. Retrospective study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-01	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-53gfpy9	<NULL>	Patients of both genders; aged between 1 and 15 years; patients that presented interproximal radiographs taken between 2011 and 2020; the most recent radiograph from each region will be included as a measurement reference for the analysis;	Interproximal radiographs that are not angled perpendicular to the tooth; are not of good quality; Individual sites in which the cementoenamel junction (CEJ) or alveolar bone crest (BC) are not visible; the presence of overlapping structures that make the evaluation unfeasible; deciduous molars that are exfoliating with extensive root resorption	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-4dk4rss	A study to evaluate innate and pro-inflammatory responses of an Ad26-based SARS-CoV-2 vaccine, an Ad26-based RSV vaccine, and an Ad26-based Ebola virus vaccine in adults aged 18 to 59 years	Not yet recruiting	Intervention	2022-09-21	<NULL>	<NULL>	5620	VAC18193RSV2008 A Randomized, observer-blind, phase 1 study to evaluate innate and pro-inflammatory responses of an Ad26.RSV.preF-based vaccine, Ad26.COV2.S vaccine and Ad26.ZEBOV vaccine in adults aged 18 to 59 years	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2022-11-03	Janssen Vaccines &amp; Prevention B.V	Faculdade de Medicina da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4dk4rss	<NULL>	Participant must have a body mass index less than 35.0 kilograms per meter square. In the investigator’s clinical judgment, participant may have a stable and well-controlled medical condition including comorbidities associated with an increased risk of progression to severe coronavirus disease-2019, as long as their symptoms and signs are stable at the time of vaccination, and these conditions receive routine follow-up by the participant’s healthcare provider. Participants will be included on the basis of relevant medical history, vital signs, and body mass index measurement at screening. - Participant agrees to not donate bone marrow, blood, and blood products from the first study vaccine administration until 3 months after receiving the last dose of study vaccine. Before randomization, participants must be either: (a) Not of childbearing potential; (b) Of childbearing potential and practicing an acceptable effective method of contraception and agrees to remain on such a method of contraception from signing the consent until 3 months after the last dose of study vaccine (including optional Ad26.COV2.S vaccination on Day 29 in Groups 2 and 3). Use of hormonal contraception should start at least 28 days before the first administration of study vaccine	Participant has a history of malignancy within 5 years before screening (exceptions are squamous and basal cell carcinomas of the skin and carcinoma in situ of the cervix, or malignancy, which is considered cured with minimal risk of recurrence). Participant has a known or suspected allergy or history of anaphylaxis or other serious adverse reactions to vaccines or their excipients (including any of the excipients of the study vaccine, or trace residues [chicken and/or egg proteins, gentamicin]). Per medical history, participant has chronic active hepatitis B or hepatitis C infection. Per medical history, participant has human immunodeficiency virus type 1 or type 2 infection. Participant has a history of acute polyneuropathy (example, Guillain-Barré Syndrome) or chronic inflammatory demyelinating polyneuropathy. Participant has abnormal function of the immune system resulting from: (a) Clinical conditions (example, autoimmune disease or immunodeficiency) expected to have an impact on the immune response elicited by the study vaccine. Participants with autoimmune disease (example, autoimmune-mediated thyroid disease, autoimmune inflammatory rheumatic disease such as rheumatoid arthritis, and Type 1 diabetes) that is stable and inactive without the use of systemic immunomodulators, and glucocorticoids may be enrolled at the discretion of the investigator; (b) Use of systemic corticosteroids within 2 months before administration of the first study vaccine until 28 days after first study vaccination. A substantial immunosuppressive steroid dose is considered to be greater than (&gt;) 2 weeks of daily receipt of 20 milligrams (mg) prednisone or equivalent. Note: Ocular, topical, or inhaled steroids are allowed; (c) Administration of antineoplastic and immunomodulating agents, example, cancer chemotherapeutic agents, or radiotherapy within 6 months before administration of study vaccine until 28 days after first study vaccination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-46n583h	Effect of Nutrisus in preventing anemia in children under six years old	Recruitment completed	Intervention	2022-09-21	<NULL>	<NULL>	5621	Acceptability and effectiveness of Nutrisus in the prevention of anemia and iron deficiency in children under six years old	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Ana Paula Grotti Clemente	Universidade Federal de Alagoas	https://ensaiosclinicos.gov.br/rg/RBR-46n583h	<NULL>	Children aged 1 to 6 years enrolled at Centro de Recuperação e Educação Nutricional who are not using iron supplementation at the time of recruitment	Children diagnosed with neurological or hematological diseases of genetic and autoimmune origin (sickle cell, hemolytic, sideroblastic and aplastic anemia, Fanconi anemia and thalassemia), who use iron supplementation at the time of recruitment, or with a diagnosis of anemia due to other nutritional causes: megaloblastic and pernicious anemias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-4jk8mk7	Evaluation of the metabolic profile of saliva and plasma associated with Periodontitis in obese and normal weight pregnant women and of proteins differentially expressed in the saliva of these women before and after delivery	Data analysis completed	Observational	2022-09-20	<NULL>	<NULL>	5617	Evaluation of the metabolic profile of saliva and plasma associated with Periodontitis in obese and eutrophic pregnant women and of proteins differentially expressed in the saliva of these women in pre and post term	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-11-09	Faculdade de Odontologia de Bauru - Universidade de São Paulo	King's College London	https://ensaiosclinicos.gov.br/rg/RBR-4jk8mk7	<NULL>	Be between 18 and 40 years old; during the 3rd trimester of pregnancy, between the 27th and 39th gestational week; with regular follow-up with the obstetrician; with adequate cognitive function during pregnancy; with no problem that required absolute rest	Twin pregnancies; individuals with neuromotor impairments; arterial hypertension during pregnancy; Gestational Diabetes Mellitus; malnutrition; overweight, therefore, body mass index between 25.00 and 29.99 kg/m2; confirmed or suspected diagnosis of SARS-CoV-2 infection; hyposalivation; subjects who were using or who used at some point in pregnancy antibiotics or any medication that could interfere with periodontal status or salivary flow, e.g. immunosuppressive drugs, anticonvulsants or calcium channel blockers; who were under orthodontic treatment or any dental treatment with another professional; with multiple tooth loss, so more than two teeth per hemiarch; self-reported systemic disease besides obesity; and users of alcohol, tobacco, and illicit drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-7j4cc2k	BETERC: Brazilian epidemiological trial evaluation rotator cuff	Not yet recruiting	Observational	2022-09-19	<NULL>	<NULL>	5615	Brazilian cohort of patients undergoing rotator cuff repair	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-10-15	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7j4cc2k	<NULL>	Adult patients of both male and female; aged over 18 years; who have a rotator cuff injury with indication for surgical repair confirmed by the exam ultrasound or magnetic resonance imaging; with a record of consent to participate in the study by signing the free and informed consent form.	Patients who refuse to register their consent by signing the term of informed consent; with incomplete documentation; who do not have an magnetic resonance images (MRI) preoperative magnetic field capable of confirming their injuries and those who lose the postoperative follow-up. Those with a history of fracture in the shoulder girdle; previous shoulder surgeries; local neoplasia or undergoing surgical treatment for re-rupture of the rotator cuff will not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-249zxxh	Development of an ointment for the treatment of cutaneous Leishmaniasis	Not yet recruiting	Intervention	2022-09-19	<NULL>	<NULL>	5616	"Development and evaluation of a topical formulation containing jucá product
(Libidibia ferrea) for the treatment of cutaneous Leishmaniasis"	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal do Amazonas - UFAM	INPA - Instituto Nacional de Pesquisas da Amazônia	https://ensaiosclinicos.gov.br/rg/RBR-249zxxh	<NULL>	Age between 18 and 70 years; both genders; Individuals considered healthy after initial clinical and laboratory evaluation; Agreement and voluntary signature of the free and informed consent form	Individuals who present alterations in the pre-treatment clinical and/or laboratory assessment; History of visceral leishmaniasis or American cutaneous leishmaniasis; Liver or kidney dysfunction, diabetes or heart disease; Allergy to the experimental treatment; Pregnant and lactating women; Alcoholics, smokers or those using medication; Patients with chronic diseases and/or infectious diseases such as tuberculosis, leprosy, human immunodeficiency virus, visceral leishmaniasis or American cutaneous leishmaniasis, among others; Patients with a medical history of visceral leishmaniasis or American cutaneous leishmaniasis; Inability or refusal to sign the informed consent form or inability to comply with the experimental protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-10c2pb73	Whole-body vibration training effective in reducing the risk of falls, balance, heart rate variability and post-traumatic stress in post-covid-19 patients?	Recruitment completed	Intervention	2022-09-16	<NULL>	<NULL>	5613	Effectiveness of a full-body vibration protocol on fall risk, balance, heart rate variability and post-traumatic stress in post covid-19 patients: randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10c2pb73	<NULL>	Patients of both genders; aged between 18 and 70 years; who developed moderate or severe forms of COVID-19 for more than 4 months; confirmed by the RT-PCR test or by detection of IgA; IgM and antibodies; will be included in the study. IgG; who have required hospitalization in a ward or ICU.	Patients with uncontrolled hypertension; who have neuromusculoskeletal disorders that compromise the performance of the assessment or treatment; recent fracture; osteosynthesis material (plates, rods or metal pins); lower limb prostheses or cardiac pacemaker; cognitive change will be excluded that limits the ability to answer the study questionnaire; risk of thromboembolism; labyrinthitis or vertigo; body weight above 120 kg; who participated in an exercise program after hospital discharge.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-10h7khvk	Effectiveness of distance exercises associated with self management booklet in patients with neck pain	Recruiting	Intervention	2022-09-16	<NULL>	<NULL>	5614	Effectiveness of telerehabilitation exercise program versus online self management booklet on pain and disability in patients with non-specific chronic neck pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-10	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-10h7khvk	<NULL>	Age between 18 and 60 years; of both genders; presence of cervical spine pain of at least 3 points on the numerical pain scale from 0 to 10; have access to the internet and ability to read and understand the portuguese language	Presence of severe musculoskeletal, cardiovascular and metabolic disorders; history of neurological injuries; use of muscle relaxants; obesity; presence of red flag with weight loss without apparent cause, fever and moderate to severe trauma; any health condition that makes it impossible to exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-6y2wtnd	Which Invisalign wear time is most effective in older adults, 7 or 14 days	Recruitment completed	Observational	2022-09-16	<NULL>	<NULL>	6050	Comparison of the efficiency of initial dental alignment with Invisalign® aligners changed every 7 or 14 days in mature adults: Randomized Clínical Trial	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-01	Centro Universitário Ingá	Centro Universitário Ingá	https://ensaiosclinicos.gov.br/rg/RBR-6y2wtnd	<NULL>	Mild to moderate crowding; Exclusively use of aligners, no accessories; No extraction treatment; No dental agenesis; Permanent dentition complete until the first molar; No previous orthodontic treatment	Previous orthodontic treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-7y3gf9r	Influence of the Use of a Smartphone Application on adherence to dietary practices and its relationship with the mental health of health professionals in times of a pandemic	Recruiting	Intervention	2022-09-15	<NULL>	<NULL>	5610	Influence of the Use of a Mobile Health Application on adherence to dietary practices and its relationship with the mental health of health professionals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-06	Universidade de Passo Fundo	Universidade de Passo Fundo	https://ensaiosclinicos.gov.br/rg/RBR-7y3gf9r	<NULL>	Get seven positive responses on the Self-Reporting Questionnaire (SRQ-20); be a professional working on the front lines of the COVID-19 pandemic; possess application mastery after training; both genders; age between 20 and 59 years	Be in nutritional monitoring at the time of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-8kbd5xn	Evaluation of Advanced Platelet-Rich Fibrin (A-PRF) associated with alternative Technique in the treatment of exposed dental root	Recruitment completed	Intervention	2022-09-15	<NULL>	<NULL>	5611	Evaluation of Advanced Platelet-Rich Fibrin (A-PRF) associated with Zucchelli Technique in the Treatment of Gingival Recession type I Cairo	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-25	Centro de Ciências Biológicas e da Saúde	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8kbd5xn	<NULL>	Patients with bilateral Cairo type 1 gingival recession in at least one of the arcades. Teeth in periodontal health. Sites with a probing depth less than or equal to 3mm. Less or equal than 5% of bleeding index. No gingival inflammation. Caries free	History of antibiotic therapy . History of anti-inflammatory drugs in the last three months. History of pregnancy at the moment of the research. History of Smoking or definitive habit interruption within five years. History of any systemic problem. History of Endodontic treatment or pulp pathology in the involved tooth. History of Pathogenic occlusal interferences. History of pre-surgery on site	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-9ktk6cv	Evaluation of the effectiveness of a educational game for the prevention of surgical site infection	Not yet recruiting	Intervention	2022-09-14	<NULL>	<NULL>	5607	Development and evaluation of the effectiveness of the Serious Game for the prevention of surgical site infection: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal do Triângulo Mineiro	Programa de Pós-Graduação strictu sensu em Atenção à Saúde	https://ensaiosclinicos.gov.br/rg/RBR-9ktk6cv	<NULL>	Healthy volunteers; Both sexes; students in the ninth and tenth period of the nursing course; age above 18 years	Volunteer with a history of dependence in the Fundamentals of Nursing discipline or in the discipline of Technical Nursing Bases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-102jnmyx	Acute Effects of Exercise Using One Joint or More Joints on Glycemia in Patients with Type 2 Diabetes	Recruiting	Intervention	2022-09-14	<NULL>	<NULL>	5609	Acute Effects of Monoarticular versus Multiarticular Strength Training on Glycemia in Individuals with Type 2 Diabetes	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-07-05	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-102jnmyx	<NULL>	Acceptance to participate in the research by signing the Free and Informed Consent Form; having a diagnosis of Type 2 Diabetes, confirmed by a blood test or medication use; minimum age of 18 years; not practicing physical exercises systematically at least twice a week; controlled glycemia using medication and having a glycemic range of control value between 100 and 300 mg/dl to perform the exercises safely.	Presence of severe autonomic neuropathy, severe peripheral neuropathy, or history of foot injuries; proliferative diabetic retinopathy, severe non-proliferative diabetic retinopathy; decompensated heart failure; peripheral amputations; muscular or joint impairment that prevents the performance of the proposed exercises and impossibility of detachment to carry out the evaluation and/or training visits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-3v9q7vx	Testing drugs that stop tooth decay	Not yet recruiting	Intervention	2022-09-13	<NULL>	<NULL>	5603	Comparative study between the effects of cariostatics in initial dental caries lesions: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-19	Gabriel Magalhães Cairo	Universidade Estadual do Sudoeste da Bahia - UESB	https://ensaiosclinicos.gov.br/rg/RBR-3v9q7vx	<NULL>	Children who have caries activity defined by the presence of at least one active initial lesion will be included (ICDAS-II Scores 1 and 2); no history of allergy to silver, colophonium, fluorine, chlorhexidine, xylitol or vehicles used in cariostatic formulations.	Children who used antibiotics in the last three months will be excluded; who use other systemic medications; who have dental elements with pulp involvement; carriers of syndromes or mental disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-7nfy2z3	Study of nutrition and health in children and adolescents in the city of Fortaleza	Recruiting	Intervention	2022-09-13	<NULL>	<NULL>	5604	Study of nutrition and health in children and adolescents in the city of Fortaleza (ensca-for)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Estadual do Ceará - UECE	Universidade Estadual do Ceará - UECE	https://ensaiosclinicos.gov.br/rg/RBR-7nfy2z3	<NULL>	Adolescents from 10 to 17 years old from public schools in the municipal education network of Fortaleza; diagnosed with obesity based on the values ​​of Body Mass Index (BMI) for age in z score of the World Health Organization (WHO, 2000)	Individuals who have any allergy or intolerance to cashew nuts; who have type 1 diabetes; who are using any vitamin or mineral supplement; who have started any treatment or follow up aimed at losing weight	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-4zfbkqv	In Utero Surgery of Fetal Lesions to the Spinal Cord: outcomes of the surgery, mothers and newborns	Terminated	Observational	2022-09-13	<NULL>	<NULL>	5605	Prenatal Repair of Myelomeningocele in a university hospital: surgery, obstetric and postnatal outcomes	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2015-10-13	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4zfbkqv	<NULL>	"Singleton pregnancy; Myelomeningocele with the upper boundary located between T1 and S1; Evidence of hindbrain herniation; Gestational age of 19.0 to 25.9 weeks at randomization
Normal karyotype; Maternal age of at least 18 years"	A fetal anomaly unrelated to myelomeningocele; Severe kyphosis; Risk of preterm birth (including short cervix and previous preterm birth); Placental abruption; Body-mass index of 35 or more; Contraindication to surgery, including previous hysterotomy in the active uterine segment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-3dzmnn6	Study of the Keraring Intrastromal Corneal Ring SG model	Recruiting	Intervention	2022-09-13	<NULL>	<NULL>	5606	Prospective post-marketing clinical follow-up study of the Keraring Intrastromal Corneal Ring SG model	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Mediphacos Indústrias Médicas S.A.	Mediphacos Indústrias Médicas S.A.	https://ensaiosclinicos.gov.br/rg/RBR-3dzmnn6	<NULL>	Patients diagnosed with keratoconus; Keratoconus in contact lens-intolerant patients; Pellucid marginal degeneration; decentralization of the highest posterior elevation point ≥ 1.25mm from the center; Keratometry with a maximum mean K of 58µm; Minimum corneal thickness of 420 µm in the 5mm optical zone; both sexes; adults and children; Patients willing and able to perform clinical examinations for follow-up for a period of 1 year after surgery	Patients with no indication for the treatment of intrastromal ring implantation; vulnerable groups	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-8ksktby	The effects of light therapy on the performance of trained subjects	Recruiting	Intervention	2022-09-13	<NULL>	<NULL>	6010	Effects of light therapy on muscle performance in trained people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-02-20	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8ksktby	<NULL>	healhy volunteers; trained men (6 months or more); body mass index: 18-30kg/m²; 18-30 years old	orthopedics injuries (2 months); open wounds; use of regular medication, alcohol, tobacco and nutritional supplementation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:27
RBR-4mhhqzk	Effect of laser therapy on the physical capacity of patients with type 2 diabetes	Suspended	Intervention	2022-09-12	<NULL>	<NULL>	5601	Acute effect of Low Power Laser (red and infrared) on the performance of patients with peripheral arterial disease in the walk test: a randomized, double-blind, placebo-controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-10	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4mhhqzk	<NULL>	Diagnosis of Type 2 Diabetes Mellitus under treatment (presentation of a medical prescription containing the prescription of oral hypoglycemic agent and/or insulin); Both sexes; Between 45 and 75 years of age; Residence in the same city of the research	"Physical limitation (orthopedic, neurological or ophthalmic) to perform the physical tests (pain above 5 on the visual scale, disability or noticeable change in gait, amaurosis); Peripheral neuropathy from another cause (Hansen&apos;s disease, alcoholism or other); Symptomatic peripheral arterial disease (ankle-brachial index &lt; 0.9 with interruption of any physical test due to claudicating pain); Painful ulcer anywhere on the lower limbs at the time of the first evaluation or during any stage of participation in the project; Amputation above the transmetatarsal; active plantar ulcer or use of implantable electrical device (contraindications for Bioimpedance); BMI ≥ 40 kg/m2;
Hospitalization in the 2 months prior to the start of the research, for any reason; COVID-19 diagnosed by examination: in the last 3 months (without hospitalization); within the last 6 months (with hospitalization without intubation) or any period prior to the survey (if intubated) or having post-COVID symptoms (regardless of the period of infection); Supervised physical exercise or treatment with electrical stimulation or phototherapy applied to the muscles of the lower limbs in the 6 months before the start of the research; Two absences from application sessions (consecutive or interspersed) while participating in the project."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-76bhgyb	Topical Treatment of Phimosis	Recruiting	Intervention	2022-09-12	<NULL>	<NULL>	5602	Topical Treatment of Phimosis: Identifying Success Factors	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-01-01	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora	Faculdade de Ciências Médicas e da Saúde de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-76bhgyb	<NULL>	Children from 3 to 10 years old; phimosis diagnosis	History of recent treatment with corticosteroids, systemic or topical, in a period of less than 6 months; inappropriate use of the prescribed medication with the presence of side effects that require treatment interruption; recurrent urinary tract infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-10vvfpcm	Efficacy and tooth sensitivity of different at-home bleaching protocols	Recruiting	Intervention	2022-09-08	<NULL>	<NULL>	5596	Efficacy and tooth sensitivity of different at-home bleaching protocols with a 10% carbamide peroxide: a randomized single-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-10vvfpcm	<NULL>	Minimum age of 18 years; good overall and oral health; anterior maxillary teeth without restorations or  carious or non-carious cervical lesions; right upper canine will be required to be A2 or darker according to the value-oriented Vita Classical shade guide (VITA Zahnfabrik, Bad Säckingen, Germany)	Dental prosthesis; visible enamel cracks; severe tooth discoloration; pregnant; lactating; patients with preexisting dental hypersensitivity; who underwent previous bleaching procedures and taking any anti-inflammatory or analgesic medicines.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-2br4cwp	Effect of two types of Shoulder Stretching on pain and mobility in Symptomatic Athletes	Not yet recruiting	Intervention	2022-09-08	<NULL>	<NULL>	5597	Effect of Posterior Shoulder Capsule Stretches in symptomatic overhead athletes with Internal Rotation Deficit: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-26	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-2br4cwp	<NULL>	Overhead athletes aged between 18 and 40 years; competitive level; difference of at least 20 degrees of limitation in internal rotation compared to the non-dominant limb; pain in activities of daily living or sports at least 2 on the Visual Numerical Scale. Athletes with a previous history of glenohumeral instability; shoulder surgery; current symptoms related to the cervical spine; or structural injuries to the shoulder complex such as a fracture; labrum or tendon injuries will not be included	Athletes who injure their shoulder and/or elbow during the study; refusal to participate in study interventions and evaluations after randomization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-3vs3gh8	Characteristics of COVID-19 patients using masks that help to breathe in a hospital in Rio de Janeiro	Recruiting	Observational	2022-09-08	<NULL>	<NULL>	5599	Profile of patients with SARS-COV-2 under Non-Invasive Ventilatory Support in a tertiary hospital in Rio de Janeiro: a retrospective observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-22	instituto de biofisica carlos chagas filho	instituto de pesquisa e ensino d'or - IDOR	https://ensaiosclinicos.gov.br/rg/RBR-3vs3gh8	<NULL>	Adult patients; 18 years of age and older; admitted to the ICU with COVID-19 confirmed via positive RT-PCR or CT scan suggestive of pneumonia caused by COVID-19	Estimated length of hospital stay less than 3 days; Patients who progressed to orotracheal intubation in less than 48 hours of hospital stay; Patients whose non-invasive ventilatory therapy has lasted less than 48 hours; Patients whose medical records lack predictive and outcome variables	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-7vkm58y	Clinical Simulation as a teaching methodology on Patient Safety	Recruitment completed	Intervention	2022-09-08	<NULL>	<NULL>	5600	Effectiveness of Clinical Simulation as a teaching tool- learning about Patient Safety: an Experimental Study	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Patrícia Freire de Vasconcelos	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-7vkm58y	<NULL>	Be a student regularly enrolled in the Undergraduate Nursing Course at Universidade Internacional da Lusofonia Afro-Brasileira; Be studying between the 6th and 8th semester.	Not having attended the subjects of Care Process in Adult Health or Surgical Center and Sterilization Material; Failure to participate in any of the procedures established in the survey.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-7zjgnrx	Effects of Physical Exercise in movements, manual hability and brain plasticity in individuals with Parkinson&apos;s disease	Recruiting	Intervention	2022-09-06	<NULL>	<NULL>	5594	Effects of Physical Exercise in motor function, manual dexterity and brain plasticity in individuals with Parkinson&apos;s disease: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Laboratório de Neurociências - Universidade Federal de São Carlos	Harvard Medical School	https://ensaiosclinicos.gov.br/rg/RBR-7zjgnrx	<NULL>	The inclusion criteria will be age between 40 to 80 years; both genders; diagnosis of Parkinson&apos;s disease as confirmed by neurologist;  stage 1-3 on the Hoeh and Yahr scale; who were not exercising at moderate intensity greater than 3 times per week within 3 months; complaints about motor impairments related to hand function (self-report);  taking stable medications for Parkinson&apos;s disease for at least 30 days	The exclusion criteria will be features suggestive of other causes of parkinsonism/ Parkinson’s-plus syndromes, unstable medical conditions (e.g., uncontrolled diabetes, uncompensated cardiac issues, heart failure, uncompensated pulmonary disease, or chronic obstructive pulmonary disease), psychiatric diseases diagnosed by a psychiatrist; dementia (Mini-Mental State Examination score less than 24), presence of another neurological disorder and hearing or visual impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-5ffkdzx	Interference of Black Soy Flour consumption on body composition, body weight, fat profile and blood sugar in Obese individuals	Recruiting	Intervention	2022-09-06	<NULL>	<NULL>	5595	Influence of Black Soy Flour Consumption on Body Composition, Body Weight, Lipid and Glycid profile in individuals with Obesity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-19	Universidade Federal do Rio de Janeiro	Empresa Brasileira de Pesquisa Agropecuária - EMBRAPA	https://ensaiosclinicos.gov.br/rg/RBR-5ffkdzx	<NULL>	women; adults; any race or color	pregnant women; lactating women; smokers; hepatopathic patients; cardiopathic patients; nephropathic patients; patients with unstable thyroid disorders; cancer; inflammatory bowel disease; food allergy/intolerance; bariatric patients who have changed more than 3 kg in the last 2 months; patients taking food supplements for three months before or during the study; patients taking anti-depressant or weight loss medications; suspected binge eating; non-compliance with the study protocol or who present complications that make it impossible to meet the eligibility criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-8h7b5dw	The use of a Topical Anesthetic (EMLA) to assess decreased pain during the Periodontal Probing exam	Recruitment completed	Intervention	2022-09-05	<NULL>	<NULL>	5592	Placebo-controlled clinical trial on the effect of an Anesthetic Gel on pain prevention during Periodontal Probing	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2019-01-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8h7b5dw	<NULL>	Volunteers aged between 18 and 60 years; of both genders, with at least five teeth in each hemi-arch (including 16, 22, 36 and 32); who had probing sensitivity and features of chronic periodontitis with probing depth greater than or equal to 5mm	Use of prophylactic antibiotics before periodontal probing; psychiatric disorders or chronic pain; clotting disorders; anticoagulation therapy; pregnant or lactating women; congenital or idiopathic methemoglobinemia; treatment with methemoglobin inducing agents; allergic to anesthetics; use of steroidal or non-steroidal anti-inflammatory drugs in the three days prior to the start of the study and patients with acute periodontal pain, pulpitis, abscesses or other acute infections	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-26chs2g	Health assessment before and after bariatric surgery	Recruiting	Observational	2022-09-05	<NULL>	<NULL>	7458	Evaluation of nutritional, inflammatory, and oxidative status of patients undergoing bariatric surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-07-09	Hospital Universitário Cassiano Antônio de Moraes	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-26chs2g	<NULL>	Adults who are 18 years of age or older; Body Mass Index greater than 40Kg/m2; Body Mass Index greater than 35Kg/m2 with comorbidities; both sexes	Pregnant women; patients using a pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:21
RBR-10jc7w38	Clinical performance of a composite resin with intelligent chromatic technology for the restoration	Recruitment completed	Intervention	2022-09-02	<NULL>	<NULL>	5590	Clinical performance of a composite resin with intelligent chromatic technology for the restoration of non-carious cervical lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-10jc7w38	<NULL>	Good general health; good oral hygiene; have at least 20 teeth under occlusion; at least two comparable non-carious cervical lesion (in size; shape and dimensions); non-retentive; deeper than 0.5 mm; and involving both enamel and dentin of vital teeth; the cavo-superficial margin cannot involve more than 50% of the enamel.	Extremely poor oral hygiene; using orthodontic devices; severe or chronic periodontitis; heavy bruxism habits; known allergy to resin-based materials or any other material used in this study; pregnant or lactating women; chronic use of anti-inflammatory; analgesic and psychotropic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-10hdj2bg	Evaluation of the pharmacist&apos;s performance in the care of hospital discharge patients in the cardiology unit of a teaching hospital in Espírito Santo	Not yet recruiting	Intervention	2022-09-02	<NULL>	<NULL>	5591	Evaluation of Pharmaceutical Services for Clinical Support to Hospital Discharge in the cardiology unit of a teaching hospital in Espírito Santo	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-30	Leonardo Coutinho Ribeiro	Empresa Brasileira de Serviços Hospitalares (EBSERH)	https://ensaiosclinicos.gov.br/rg/RBR-10hdj2bg	<NULL>	Patients over 18 years of age; both sexes, admitted to the Cardiology Ward, who entered the institution under study on an emergency basis, agreed to sign the free and informed consent form (FICT) and voice recording term	Electively admitted patients; no contact phone; without autonomy to self-administer, without assistance from others, medication and who are not accompanied by a family member or caregiver who can provide necessary and reliable information about their treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-99m424c	Efficacy of acupuncture on quality of life, functional performance, shortness of breath, and lung function in patients with Pulmonary emphysema: randomized clinical trial	Not yet recruiting	Intervention	2022-09-01	<NULL>	<NULL>	5587	Efficacy of acupuncture on quality of life, functional performance, dyspnea and pulmonary function in patients with Chronic obstructive pulmonary disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-99m424c	<NULL>	Clinical diagnosis of COPD according to GOLD; ability to offer written authorization or indicate a person to read the Free and Informed Consent Form (ICF), with the agreement of the research participant; there will be no age limit, however individuals who are over 65 years old must have preserved cognitive function according to the Mini-Cog (individuals under 65 years old will not do the Mini-Cog); clinical stability in the month prior to the beginning of the protocol.	Patient with a previous medical diagnosis of a disease that affects the cognitive and does not allow the understanding of the questionnaires; individuals unable to perform any of the assessments; individuals who had exacerbations of the condition in the month prior to the beginning of the protocol; prior acupuncture therapy; being in a rehabilitation group or having been in the last 3 months; individuals who present an exacerbation of the clinical condition during the collection period will be excluded;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-5syg5gk	Assessment of possible effects of manual therapy on the nervous system	Recruiting	Intervention	2022-09-01	<NULL>	<NULL>	5588	Neurophysiological assessment of motor responses determined by fascial manipulation: a randomized, crossover, double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal do ABC	Universidade Federal do ABC	https://ensaiosclinicos.gov.br/rg/RBR-5syg5gk	<NULL>	Healthy male and female volunteers aged between 18 and 50 years who agree to sign the informed consent form and who meet the criteria listed below will be included. Do not make regular use of psychoactive substances and or with diagnosed psychopathies; They do not have body deformities, stiffness, degenerative changes, osteoarthritis, rheumatoid arthritis and/or related pathologies; Have no history of orthopedic surgery on the trunk or axial segments of the limbs; Do not have contraindications for the use of Transcranial Magnetic Stimulation such as the presence of metals in the skull or implanted devices, history of epilepsy, pregnancy, use of drugs that may interfere with cortical electrical activity such as anticonvulsants, antidepressants and antipsychotics and complications with exposure to magnetic fields ; They do not have metallic implants in the skull, metallic wires implanted in the stimulation region, cochlear implants and pacemakers; They are not incapable of understanding the content of the assessment tools used; Do not present any other situation that the researchers consider as a limiting factor for the study	Volunteers who present any discomfort, psychological or physical, will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-6zw2fnb	Determination of glycemic response to the consumption of two specialized formulas for glycemic control	Data analysis completed	Intervention	2022-08-31	<NULL>	<NULL>	5586	Glycemic response of individuals to the consumption of formula for enteral nutrition	<NULL>	1, n/a, single-blind	1	<NULL>	<NULL>	<NULL>	2018-07-16	Prodiet Medical Nutrition	Food Research Center (Fundação de Amparo à Pesquisa do Estado de São Paulo) / Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6zw2fnb	<NULL>	Healthy volunteers; aged between 18 and 49 years; both genders; with good health conditions according to a report of absence of diabetes, renal and gastrointestinal diseases and hyperthyroidism; having a Body Mass Index (BMI) within the normal range of 18.5 to 24.9 kg/m²; with normal glucose tolerance (between 70 and 99 mg/100 mL in the morning, after fasting for 10 hours) and maximum postprandial blood glucose of 140 mg/100 mL and close to fasting after 2 hours	Volunteers using any type of medication that could affect digestion and absorption of food (antibiotics, medications for diarrhea and constipation) during the study period; hormone therapy; presence of pregnancy or breastfeeding; family history of diabetes; significant glycemic variations in the glycemic response test to the reference food	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-3bth6y2	Evaluation of the use of Laser-ILIB to improve pain and change in sensitivity in patients with Diabetic Neuropathy	Recruiting	Intervention	2022-08-30	<NULL>	<NULL>	5585	Evaluation of the effectiveness of the Laser- ILIB in the control of pain and sensory changes associated with Diabetic Neuropath	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-11	Faculdade de Farmácia da Universidade Federal da Bahia	Faculdade de Farmácia da Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-3bth6y2	<NULL>	Volunteers with diabetic neuropathy; both genders; age between 20 and 79 years; pain for more than 6 months with an intensity greater than 4 on the VAS scale (Visual Analogue Scale)	Cognitive impairment; chronic pain of another origin; invasive procedures less than 2 months; use of pain staging medication for less than 30 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-4wkdqx4	Assessment of skin irritability after using a health product	Recruitment completed	Intervention	2022-08-29	<NULL>	<NULL>	6528	Assessment of primary dermal irritability, accumulated dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-30	Medicin Instituto da Pele Ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-4wkdqx4	<NULL>	Participants of both sexes aged 18 to 70 years; Phototype: I, II, III and IV (according to adapted scale); Skin of the application region integrates; Agreeing to follow the test procedures and to attend the clinic on the days and times determined for medical evaluations and for application and reading of dressings; Understanding, consent and signing of the Free and Informed Consent Term (ICF)	Participants who have been diagnosed with COVID 19 in the last 4 weeks or who have symptoms of fever, dry cough, tiredness, body aches or other discomforts; Pregnancy or risk of pregnancy and/or lactation (when women); Use of anti-inflammatory drugs and/or immunosuppressive drugs for up to three months before selection; Immunosuppression by drugs or active disease; Decompensated endocrinopathies; Personal history of atopy; Intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; Expect intense exposure to sunlight or tanning sessions during the study period; Provision of bathing in the sea, swimming pool or sauna during the study; Practice of water sports during the study; Dermographism; Use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 week before the start of the study; Aesthetic and/or dermatological treatment on the body within 03 weeks before selection; Scheduled vaccination during the study period or up to 3 weeks before selection; History of sensitization, irritation or photosensitization to topical products; Active skin pathologies (local and/or disseminated) that may interfere with the study results; Skin reactivity; Use of new drugs/cosmetics during the study; Previous participation in studies with the same product; Congenital or acquired immunodeficiency; Relevant medical history or current evidence of alcohol or other drug abuse; Known or suspected history of intolerance to any ingredient in study products (test or comparative product); History of non-adherence or unwillingness to adhere to the study protocol; Employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study; Other conditions considered by the researcher as reasonable for disqualification from participating in the study. If yes, it should be described under observation in the clinical record	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:46
RBR-6jv3vp8	Evaluation of the effect of Electrical Stimulation in individuals with low back pain	Recruiting	Intervention	2022-08-26	<NULL>	<NULL>	5583	Evaluation of the acute effect of Transcutaneous Electrical Stimulation in individuals with nonspecific low back pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-20	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6jv3vp8	<NULL>	Age between 18 and 45 years; presence of  low back pain measured by the numerical visual scale of greater than or equal to 3 at the time of evaluation	Individuals who underwent pharmacological or non-pharmacological treatments for low back pain less than 48 hours before the evaluation; pregnant women; patients undergoing spinal surgery; individuals with diagnoses of pathologies in the spine such as herniated disc; spondylolisthesis; spinal canal stenosis; equine cause syndrome; fractures; cancer; individuals who have any contraindications to the use of electrotherapy, such as the presence of skin lesions; abnormal sensitivity; infectious; blood diseases; cardiac pacemakers; inability to answer questionnaires; electrophobia; fibromyalgia;  psychiatric problems; refusal to sign the Free and Informed Consent Form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-3mywq86	Effect of Non-Invasive Neuromodulation in improving balance and gait of individuals with Parkinson´s disease	Data analysis completed	Intervention	2022-08-26	<NULL>	<NULL>	7129	Effectiveness of Transcranial Direct Current Stimulation associated with Physiotherapy in improving balance and gait of individuals with Parkinson´s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-30	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-3mywq86	<NULL>	Medical diagnosis of Parkinson&apos;s disease according to the criteria of the London Brain Bank (Uk Parkinson&apos;s Disease Society Brain Bank Clinical Diagnostic Criteria); age range between 50 and 85 years; not institutionalized; mini-mental score that does not characterize cognitive impairment; Hoehn&amp;Yahr scale between 1.5 and 3.0; which accept to participate of the project and sign the consent term according to the criteria of the Ethics Committee of the Universidade Estadual de Londrina, according to the parecer 466/2912 (National Health Council)	Individuals who perform another therapeutic treatment beyond medication; that has change in medication during the study; or those with associated diseases, such as neurological disorders, severe heart disease, amputations, cognitive or understanding deficits. Change in the stabilization of the antiparkinsonian medication doses throughout the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:09
RBR-8pgbfpv	Effect of flavanones of orange juice absorption on blood lipid profile	Recruitment completed	Intervention	2022-08-25	<NULL>	<NULL>	5580	Inter-individual variability in the bioavailability of citrus flavanones and on the lipid profile in humans	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Hospital Universitário da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8pgbfpv	<NULL>	Healthy individuals; aged 19 to 40 years; with nutritional diagnosis of eutrophy and / or overweight (BMI = 19.0-24.99 Kg / m2 and 25 to 29.9 Kg / m2). Do not have a history of cardiovascular, gastrointestinal, hepatic or renal dysfunction; not be an alcoholic (daily alcohol consumption); not be diabetic; not have any type of infection; not using vitamin and mineral supplements, in addition to antibiotics, antacids or medication for diarrhea or constipation; not be a smoker; not having an aversion to orange juice; women volunteer cannot be pregnant, breastfeeding or undergoing hormone replacement therapy for menopause.	Present a history of cardiovascular, gastrointestinal, hepatic or renal dysfunction; being an alcoholic (daily alcohol consumption); being diabetic; presenting any type of infection; be using vitamin and mineral supplements, in addition to antibiotics, antacids or medications for diarrhea or constipation; being a smoker; aversion to orange juice; pregnant women, lactating women or menopausal hormone replacement therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-7bvmccs	Is self-selected exercise (where people can choose the load) able to provide health benefits?	Not yet recruiting	Intervention	2022-08-25	<NULL>	<NULL>	5581	Effect of imposed and self-selected exercise on perceptual and affective responses, muscle function and quality and functionality in strength training in elderly women and men	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7bvmccs	<NULL>	Be over 60 years of age; Have conditions that allow the regular practice of exercise; Submit negative responses to all items on the Revised Physical Activity Readiness Questionnaire (rPAR-Q); Not having participated in strength training programs in the last 6 months.	Be under 60 years of age; Not having conditions that allow the regular practice of exercise; Provide positive responses to all items of the Revised Physical Activity Readiness Questionnaire (rPAR-Q); Be physically active.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-4mhxppx	The effect of Photodynamic Therapy associated with Periodontal Treatment	Recruiting	Intervention	2022-08-25	<NULL>	<NULL>	5582	Evaluation of the effectiveness of adjuvant Photodynamic Therapy to non-surgical Periodontal Therapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade Federal De Minas Gerais	Universidade Federal De Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4mhxppx	<NULL>	Individuals over 35 years of age; with at least 12 teeth; with generalized stages 2 and 3 periodontitis; who have teeth affected by periodontitis in the four quadrants	Individuals undergoing periodontal treatment or undergoing antibiotic therapy in the last 3 months; smokers; pregnant and lactating women; individuals using anticoagulant medication; with a positive diagnosis of Human Immunodeficiency Virus (HIV); who present systemic conditions as a risk factor for periodontitis; who have contraindications for performing a clinical periodontal examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-8ymy2sw	Development of an Artificial Intelligence solution for remote movement correction for Physical Rehabilitation	Recruiting	Intervention	2022-08-24	<NULL>	<NULL>	5576	Development and validation of an Artificial Intelligence-based solution for remote motion detection and correction of exercises for Motor Rehabilitation	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Hospital Israelita Albert Einstein	LinkFit	https://ensaiosclinicos.gov.br/rg/RBR-8ymy2sw	<NULL>	Healthy volunteers; over the age of 18; of both sexes; high school education or higher; time of injury and pain greater than six months; and who have been elected for conservative treatment	Volunteers with sensory motor; cognitive; visual and or auditory deficits; presence of neurological and or psychiatric comorbidities; previous or recent surgeries in the segments mentioned above for study; other pain syndromes; discharge after conventional physical rehabilitation program in a period less than two months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-7gkw3d4	Use of Photobiomodulation Therapy for prevention and treatment of Acute Radiodermatitis in women with Breast Neoplasm	Recruiting	Intervention	2022-08-24	<NULL>	<NULL>	5577	Effects of Photobiomodulation Therapy in the prevention and treatment of Acute Radiodermatitis in women with Breast Neoplasm: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade de São Paulo	Hospital São Domingos	https://ensaiosclinicos.gov.br/rg/RBR-7gkw3d4	<NULL>	Women over eighteen years of age; diagnosed with breast cancer; who may have undergone surgical treatment, whether radical or conservative; with indication of starting adjuvant or neoadjuvant radiotherapy will be included.	Pregnant patients who underwent previous irradiation of the area; who are undergoing concomitant chemotherapy; who present postoperative complications such as dehiscence of the surgical wound or presence of seroma; women with malignant neoplastic wound or with the presence of dermatoses in the area to be be irradiated; women who miss treatment on the proposed day; who have been hospitalized due to an oncological emergency or who died during the course of the research; women who present grade III or IV radiodermatitis after the beginning of the radiotherapy sessions who need to interrupt the treatment until the lesion improves.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-4gxbszn	Effects of Mentholated Popsicle on vasopressin, thirst and discomfort	Recruitment completed	Intervention	2022-08-24	<NULL>	<NULL>	5578	Effects of Mentholated Popsicle on vasopressin, osmolarity, intensity, thirst discomfort and oral dehydration: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-20	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-4gxbszn	<NULL>	Age between 18 and 50 years; male, not be smoker; not be alcoholic; daily fluid intake habits: minimum of 2 liters of water / day	Kidney failure; systemic arterial hypertension; diabetes; hydroelectrolytic disorders such as vomiting and diarrhea; women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-8brmb9m	Study with previously collected data from patients who have the Keraring keratoconus ring implanted	Recruiting	Observational	2022-08-24	<NULL>	<NULL>	5579	Retrospective postmarketing clinical follow-up study of Keraring Intrastromal Corneal Ring	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-01	Mediphacos Indústrias Médicas S.A.	Hospital Oftalmológico de Brasília - HOB	https://ensaiosclinicos.gov.br/rg/RBR-8brmb9m	<NULL>	Patient with keratoconus; Both sexes; Any age; Patients who have Keraring implanted in the eye	Patients who do not have Keraring implanted in the eye	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-103c2tr6	Effect of the application of Osteopathic Techniques on pulmonary function and quality of life of individuals with Chronic Obstructive Respiratory Diseases	Not yet recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5568	Effect of Manual Osteopathic Techniques (BMT) on lung function and quality of life in patients with Chronic Obstructive Pulmonary Disease (COPD)	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2022-09-01	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-103c2tr6	<NULL>	Adult men and women; age group between 35 and 70 years; patients with Chronic Obstructive Pulmonary Disease; stable clinical picture; no exacerbation of the condition in the last three months; agreement and signature of the Free and Informed Consent Form	Pregnant women; individuals with advanced osteoporosis; fractures in the consolidation phase; cancer; thoracic surgeries; decompensated heart disease; systemic arterial hypertension; physical or cognitive factor that limits or prevents the understanding and execution of the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-10smbw65	Incidence of low pressure in the weaning of vasopressor drugs	Recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5569	Incidence of hipotension in the weaning of vasopressor drugs	<NULL>	4, randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2022-05-18	Hospital Nossa Senhora da Conceição	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-10smbw65	<NULL>	Adult patients; both genders; older than 18 years; hospitalized for septic shock; in use of noradrenaline and vasopressin associated	Patients in whom the reduction of these vasopressors (noradrenaline and vasopressin) is related to the introduction of adrenaline or is related to the process of withdrawal of therapeutic support (therapeutic limitation)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-723bk5p	The effect of Alogliptin in the prevention of Type 1 Diabetes Mellitus	Not yet recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5570	Evaluation of the effect of Alogliptin in the prevention of type 1 Diabetes Mellitus	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2022-09-30	Universidade Federal do Ceará	Universidade de São Paulo - Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-723bk5p	<NULL>	Patients of both sexes aged between 18 and 35 years; Confirmed diagnosis of stage 2 autoimmune diabetes mellitus through the presence of 1 or more positive pancreatic islet autoantibodies anti-insulin antibodies, anti-GAD, IA-2, anti-ZnT8A associated with 2 blood glucose values fasting glucose between 100-124 mg/dL or 2 glycated hemoglobin values between 5.7%-6.4% or a fasting glucose between 100-124 mg/dL + 1 glycated hemoglobin value between 5.7%-6.4%	Pregnant women, breast-feeding women or those who wish to conceive in the last 3 months; Patients with a clinical-laboratory diagnosis of diabetes; Patients on insulin therapy or any other hypoglycemic therapy at the time of inclusion; chronic kidney failure carriers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-9b3mcsx	Nursing care based on Theory of Self-Care for people with chronic Chagas Disease	Not yet recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5571	Nursing care based on Orem&apos;s Theory of Self-Care for patients with chronic Chagas Disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-29	Faculdade de Ciências da Saúde da Universidade do Estado do Rio Grande do Norte	Faculdade de Ciências da Saúde da Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-9b3mcsx	<NULL>	People with Chagas Disease in the chronic form who are registered and treated at the Chagas Disease Outpatient Clinic; Be over 18 years old	For some ethical or legal-legal reason they are unable to respond; Those who do not have the physical conditions to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-5vyr8bp	Evaluation of the use of Probiotics in the intestinal flora, nutritional status and immune system of patients who underwent Surgery to Remove the Stomach for Gastric Cancer	Recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5572	Effects of the use of Probiotics on the gut microbiota, clinical-nutritional and immunological status of patients undergoing Gastrectomy for Gastric Cancer: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	UFAM- Universidade Federal do Amazonas	FCECON - Fundação Centro de Controle de Oncologia do Estado do Amazonas.	https://ensaiosclinicos.gov.br/rg/RBR-5vyr8bp	<NULL>	Inclusion criteria for groups G1 and G2: patients with indication for total or partial gastrectomy, with TNM staging = T1, T2, T3 (without neoadjuvant chemotherapy); patients with indication for gastrectomy only for cancer; ages between 18 to 60 years. Inclusion criteria for group G3 (negative-healthy control): People who do not have a family history of gastric cancer; people who are not blood type A+; people with no known co-morbidities; ages between 18 to 60 years; people of the same socioeconomic level (average level) of patients in the G1 group	Exclusion criteria for groups G1 and G2: Patients previously treated for other neoplasms; patients undergoing gastrectomy in the palliative setting (bleeding or obstruction); use of probiotics and prebiotics in the last 15 days; Patients who are unable to comply with all follow-up steps; patients diagnosed with other morbidities that alter energy metabolism and food intake, such as HIV/AIDS, Diabetes Mellitus; pregnant women; Autoimmune diseases; Liver and Kidney diseases; Lactose Intolerant; Gluten; Inflammatory Bowel Diseases; Infection in force; use of antibiotics 15 days before surgery; patients who are unable to perform electrical bioimpedance because they have MCP (pacemaker); edema, pregnant women; women in the menstrual period, Titanium plaques in some part of the body; indigenous; patients who for some reason had their surgeries suspended during follow-up; patients who, due to worsening of the surgical condition, need ICU; patients who underwent mechanical colonic preparation in the last 30 days; immunosuppressed patients; Patients who are not Amazonians. Exclusion criteria for group G3 (negative-healthy control): People who are unable to comply with all the stages of follow-up; use of probiotics and prebiotics in the last 15 days; use of antibiotics 15 days before the start of the research; people who are unable to perform electrical bioimpedance because they have MCP (pacemaker); edema; pregnant women; women in the menstrual period, Titanium plaques in some part of the body; indigenous	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-7jjj2pw	Influence of Anesthesia in the Ultrassound measurement of the Optic Nerve in Gynecological Surgeries	Recruiting	Intervention	2022-08-23	<NULL>	<NULL>	5573	Influence of the anesthetic technique (Total Intravenous Anesthesia X Balanced Anesthesia) on the behavior of measuring the Optic Nerve Sheath Diameter by Ultrasound in Laparoscopic Gynecological Surgeries. Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-7jjj2pw	<NULL>	Women; Older than 18 years; Laparoscopic gynecological surgery requiring steep Trendelemburg positioning; Pelvic oncologic surgery requiring steep Trendelenburg positioning; Accept to participate in the study.	Surgical procedure expected to take less than 120 minutes; Ocular pathologies that prevent the measurement of the optic nerve sheath diameter; History of intracranial hypertension; Active neurological diseases; History of transient ischemic attack; Presence of carotid disease; cerebral edema; Glaucoma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-8xfsjsc	Follow-up of patients hospitalized with COVID-19 in the northwest region of Paraná.	Recruitment completed	Observational	2022-08-23	<NULL>	<NULL>	5574	Clinical and Immunological Surveillance of hospitalized patients with COVID-19 in the Northwest macro-region of the State of Paraná	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-05-17	GlucoScan Whatch	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-8xfsjsc	<NULL>	Participants aged 18 or over; both genders; non pregnant	Worsening of the disease; ICU admission, intubation or any other factor that may occur; pregnant women; death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-3sj38mq	Asthma attacks: a study on the origin and prevention in Brazil	Recruitment completed	Intervention	2022-08-23	<NULL>	<NULL>	5575	Asthma attacks: a study of causality and prevention in Brazil	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-08	Associacao ProAR	Secretaria Municipal de Saúde de Salvador	https://ensaiosclinicos.gov.br/rg/RBR-3sj38mq	<NULL>	Age 18 years, without distinction of sex;  Emergency unit care due to severe asthma attacks; Residing in the Railway District and being linked to a Family Health Unit District; Diagnosis of asthma by physician.	"Pregnancy or lactation; Patients with impaired comprehension and verbal communication; Participating or having participated in a clinical trial 6 months prior to the visit; Diagnosis of comorbidities that hamper assessment of asthma: other respiratory diseases, history of
cerebrovascular accident (CVA), neurological disease, congestive heart failure (CHF), myopathies,
psychiatric diseases and advanced neoplasia; History of smoking greater than or equal to 10 packets per year; Be regularly monitored at an asthma health service; Do not have a landline or mobile phone."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-7f4jy8j	Effects of Manual Techniques applied to the cervical spine on the nervous system of the elderly	Data analysis completed	Intervention	2022-08-22	<NULL>	<NULL>	5566	Effects of Osteopathic Manipulative Treatment (OMT) on the functionality of patients with Congestive Heart Failure: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2013-10-01	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7f4jy8j	<NULL>	Age equal to or greater than 60 years; physically active; normotensive	Subjects unable to remain in the stand up position for at least 10 minutes; patients with rheumatological diseases; subjects with acute and/or chronic joint pain; subjects with cardiovascular disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-3vxknd7	Pre-anesthetic evaluation of 700 urological patients. Study based on past data	Recruitment completed	Observational	2022-08-19	<NULL>	<NULL>	5563	Outpatient pre-anesthetic evaluation of 700 urological patients in a university hospital with analysis of perioperative outcomes. Retrospective study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-01	Faculdade de Medicina da Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-3vxknd7	<NULL>	Patients of both genders; over 18 years old; undergoing urological surgery	Non-urological surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-392cxdp	Effects of the physiotherapy in the motor functions and quality of life in Parkinson&apos;s disease	Recruitment completed	Intervention	2022-08-19	<NULL>	<NULL>	5565	Effects of a physiotherapy treatment protocol for motor functions and quality of life in Parkinson&apos;s disease: experimental study	<NULL>	2, non-randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2017-10-01	Unidade Universitária Goiânia-ESEFFEGO Universidade Estadual de Goiás	Unidade Universitária Goiânia-ESEFFEGO Universidade Estadual de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-392cxdp	<NULL>	Parkinson&apos;s disease or Secondary Parkinsonism, diagnosed at least six months ago, in stages 1, 2 or 3 of the Hoehn and Yahr (HY) scale or with an equivalent motor condition, in the case of secondary parkinsonism; Walks with total or modified independence; Age between 40 and 70 years, under medical supervision for at least 2 months; Medical authorization for the practice of exercises; Makes regular use of antiparkinsonian medication.	Surgery for Parkinsonism; Cardiovascular diseases or musculoskeletal disorders (rheumatological, orthopedic, traumatological, arthrodesis) that contraindicate physical exercise; Great limitation of joint movement in any body segment; Secondary balance disorders, such as severe vestibulopathies; Severe cognitive impairment, which prevented the understanding of verbal instructions, confirmed by the Mini Mental State Examination (MMSE), with a score lower than 24 points (8 years of schooling), less than 18 points (4-7 years of schooling) or less than 14 points (illiterate people).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-55vv9b2	Creatine intake in hemodialysis patients	Recruitment completed	Intervention	2022-08-18	<NULL>	<NULL>	5562	Evaluation of creatine supplementation in renal hemodialysis patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Faculdade de Medicina	Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-55vv9b2	<NULL>	chronic kidney disease; both genders; age between 18 to 60 years; hemodialysis treatment	Diagnosis of impaired cognitive function; communication difficulties; hearing deficiency; amputations	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-4b5kzhd	Antibody persistence at 6 months or more in individuals primed with 2 doses of an inactivated vaccine who received a heterologous or homologous third dose – extension of study RHH_001 and safety and immunogenicity of a 4th dose with recombinant covid-19 vaccine (AstraZeneca/Fiocruz) or mRNA covid-19 vaccine (Comirnaty, Pfizer/ Wyeth)	Not yet recruiting	Intervention	2022-08-17	<NULL>	<NULL>	5557	Persistence of binding and neutralizing antibodies against SARS-CoV2 strains at 6 months or more after a third dose with recombinant covid-19 vaccine (AstraZeneca/Fiocruz), mRNA covid-19 vaccine (Comirnaty, Pfizer/ Wyeth), recombinant covid-19 vaccine (Janssen) or adsorbed inactivated Covid-19 vaccine Coronavac (Sinovac/ Butantan) in subjects primed with two Sinovac/Butantan doses – extension of study RHH_001 and assessment of safety and immunogenicity of 4th dose with recombinant covid-19 vaccine (AstraZen	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2022-10-15	Instituto D&apos;Or de Pesquisa e Ensino	Universidade de Oxford	https://ensaiosclinicos.gov.br/rg/RBR-4b5kzhd	<NULL>	Participants in study RHH 001 per protocol population who were fully evaluable. Those participants included in previous neutralization assay subsets will be targeted for enrolment first if operationally feasible; Subjects willing and able to provide informed consent prior to any study procedure; Participants willing and able to comply with the study procedure; Subjects who had received heterologous or homologous third vaccine dose 6 months or more prior to this study. For part 2 in addition: nformed consent to receive 4 th vaccine dose, AstraZeneca/Fiocruz or Pfizer/Wyeth; No contraindication against AstraZeneca/ Fiocruz or Pfizer/ Wyeth SARSC0V2 vaccine; For females of childbearing potential: willingness to practice continuous effective contraception during the study and a negative pregnancy test on the days on day of vaccination.	Any additional SARSCoV2 vaccine after the 3rd dose in study RHH 001. For part 2 in addition: Participants with a history of serious vaccine-related adverse reaction or serious allergic reaction (e.g., anaphylaxis) to any study vaccine component, as described in the last summary of product characteristics for AstraZeneca/Fiocruz or Pfizer/Wyeth; Participants with a known bleeding disorder that, in the investigator’s opinion, would contraindicate intramuscular injection; Participants with any progressive or serious neurological disorder, seizure disorder or history of Guillian-Barré syndrome; Participants given treatment with immunosuppressant therapy within the last 90 days, including cytotoxic agents or systemic corticosteroids or planned receipt during the study period. If a short-term cycle of immunosuppressant systemic corticosteroid dose has been used to treat acute disease, the participant should not be enrolled in the study until corticosteroid therapy has been discontinued for at least 15 days prior to the first study vaccination. In case the participant has been on an immunosuppressant dose of a depot, intramuscular or intra-articular corticosteroid, 60 days should be waited for their enrolment in the study. Inhaled/nebulized, intra-articular, intrabursal or topical (skin or eyes) corticosteroids are allowed; Participants with autoimmune diseases, other than: Hashimoto thyroiditis, vitiligo, psoriasis, discoid lupus and the like; HIV positive participants and/or in treatment for HIV; Participants given any other investigational product within the 30 days prior to administration of 4th dose or who intend to take part in another clinical trial at any time during this study conduction; Participants given any other licensed vaccine within 14 days prior to enrolment in this study or who plan to receive any vaccine up to 28 days after vaccination; Participants given treatment with Rituximab or any other anti CD20 monoclonal antibody within 9 months prior to administration of 4 th dose or planned during the study period; Administration of intravenous immunoglobulins and/or any blood products within 3 months prior to enrolment or planned dosing during the study period; Participants with any condition that, in the investigator’s opinion, could interfere with the status primary objectives or represent an additional risk for the participant. Temporary exclusion criteria for both Part 1 and Part 2: Participants with a recent history of COVID19 (minor 4 weeks prior to visit 1) will be delayed until 4 weeks after diagnosis; Participants with fever major 37.5 °C (axillary) or any acute disease at baseline (Day 1) or within the 3 days prior to randomization. Febrile participants with mild diseases may be enrolled at the investigator’s discretion once fever has resolved.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-6d36dgq	Evaluation of the modern indocyanine green dye in the breast cancer scenario	Recruitment completed	Intervention	2022-08-17	<NULL>	<NULL>	5558	Evaluation of the efficacy of using indocyanine green associated with fluorescence in sentinel lymph node biopsy	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-02	Universidade Federal de São Paulo	Hospital Regional do Câncer de Presidente Prudente	https://ensaiosclinicos.gov.br/rg/RBR-6d36dgq	<NULL>	Clinically negative axillary breast cancer; present surgical indication	T4 (chest wall or skin involvement or inflammatory); N1 (single lymph node affected); N2 (conglomerate of affected lymph nodes; N3 (supra or infraclavicular lymph node involvement; Having undergone neoadjuvant chemotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-8t983f7	Whole Body Vibration to Improve Functional Capacity, Muscle Strength and Thickness, Functionality and Quality of Life of Post-Covid-19 Patients	Recruiting	Intervention	2022-08-17	<NULL>	<NULL>	5559	Effect of wholy body vibration on capacity Functional, muscular strength and strength, functionality and quality of life of patients after covid-19: a study controlled and randomized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-11-03	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-8t983f7	<NULL>	Sobreviventes de Covid-19 em formas moderadas e ou graves; internação em enfermaria e/ou unidade de terapia intensiva; confirmado por teste de swab ou detecção de anticorpos no sangue; ambos os sexos; 18 e 70 anos	patients with uncontrolled hypertension; impairment of the neuro-musculoskeletal system that impairs participation in the proposed assessment or training; ; cognitive impairment that prevents responding to study questionnaires; prosthesis and/or metal pins and implants in lower limbs and pacemaker; recent unconsolidated fracture; risk of thromboembolism; vertigo and labyrinthitis; who have participated in a rehabilitation program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-8m478dx	Intervention Programs with Physical Exercises and their acute effect on cognitive performance	Recruitment completed	Intervention	2022-08-17	<NULL>	<NULL>	5560	Motor Intervention Programs in schoolchildren: acute effect of Physical Exercise on cognitive performance	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-13	Marcos Moraes	Universidade de Santa Cruz do Sul (Unisc)	https://ensaiosclinicos.gov.br/rg/RBR-8m478dx	<NULL>	Have available time to attend the exercise program on specific days and times; do not present contraindications for the practice of physical exercises, both genders, age between 9 and 10 years	Not being literate; students suffering from an illness or injury, or some other disorder	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-57y6x67	Prognostic significance of Preoperative Electrocardiogram in patients submitted to Surgical Intervention under General Anesthesia	Terminated	Intervention	2022-08-17	<NULL>	<NULL>	5561	The importance of Preoperative Electrocardiogram in healthy patients above 50 years old submitted to Elective Non-Cardiac Surgical Intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-13	Instituto Brasileiro de Controle do Câncer - IBCC/ Oncologia Clínica - SP	Instituto Brasileiro de Controle do Câncer - IBCC/ Oncologia Clínica - SP	https://ensaiosclinicos.gov.br/rg/RBR-57y6x67	<NULL>	Volunteers over 50 years of age; of both genders; with solid neoplasms; in elective surgical programming under general anesthesia; no uncompensated comorbidities; with normal physical examination at the time of preoperative clinical evaluation	Abnormal physical examination at the time of preoperative clinical evaluation; age below 50 years; deaths prior to elective surgical treatment under general anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-7wvr64k	Evaluation of the prophilatic effects of the flavonoid Hesperidin Methyl Chalcone on Delayed Onset Muscle Soreness in humans	Recruiting	Intervention	2022-08-16	<NULL>	<NULL>	5554	Evaluation of the prophilatic effects of the flavonoid Hesperidin Methyl Chalcone on Delayed Onset Muscle Soreness in humans	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade Norte do Paraná	Universidade Norte do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7wvr64k	<NULL>	Male; age between 18 and 45 years old; and to be able to develop the proposed exercise-induced muscle pain model.	Musculoskeletal and/or neurological lower limby injuries diagnosed at the time of screening; chronic use of anti-inflammatory, antidepressant and/or analgesic drugs will be considered an exclusion factor (considering that they may interfere in the analysis of some parameters that will be evaluated in the study, such as muscle pain and production of cytokines and other biological markers); calorie-restricted diet; and ergogenic supplementation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-9w7kspz	Educational intervention in parental stress	Recruitment completed	Intervention	2022-08-16	<NULL>	<NULL>	5555	Efectiveness of Educational Intervention in parental stress in intensive care unit: experimental study	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-11	Universidade Federal do Piauí	Universidade Estadual do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-9w7kspz	<NULL>	Mother with newborn (NB) admitted to the Neonatal Intensive Care Unit - NICU of any age; does not have previous experience with a child hospitalized in the Neonatal Intensive Care Unit - NICU; attend the Neonatal Intensive Care Unit - NICU daily during the intervention; be a mother of a newborn - Newborn between 28 to 42 weeks of gestational age	Mothers of clinically stable newborns on admission and with the perspective of hospitalization in the Neonatal Intensive Care Unit - NICU within 72 h; mothers who present evidence of psychiatric disorders or/and evidence of psychoactive substance abuse; mothers of newborns - NB with structural (physical deformity, except polydactyly), functional (motor alterations) or metabolic (inborn errors of metabolism) congenital anomalies that can cause serious repercussions for the newborn; mother of a newborn who was born in another hospital and later admitted (after 72 hours of life); Mother of a newborn who has been or will undergo a surgical procedure; Mothers who will be discharged from the newborn before the second measurement of parental stress, being considered loss to follow-up; Mother who, during data collection, presents respiratory symptoms and/or is positive for SarS-cov-2 or reports a positive family member for Sars-cov-2	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-9jcgqhh	Influence of Gingiva Retraction with Cotton Cord in the treatment of tooth sensitivity	Recruiting	Intervention	2022-08-16	<NULL>	<NULL>	5556	Influence of Gingiva Retraction with Cotton Cord in the treatment of tooth sensitivity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Escola Técnica de Saúde da Universidade Federal de Uberlândia	Escola Técnica de Saúde da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9jcgqhh	<NULL>	Volunteers with dentin hypersensitivity. Present all the teeth in the mouth. Age between 18 and 60 years	Presence of dentinal hypersensitivity due to the presence of caries or unsatisfactory restorations. Being undergoing dental treatment. Present periodontal disease. Have unsatisfactory oral hygiene. Use of extensive dentures. Severe bruxism. Uncontrolled diseases. Use of medications that interfere with salivary flow. Pregnant and lactating women. Smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-9h2kdm9	Comparison of pain levels in nasopalatine nerve blocks using two different techniques	Data analysis completed	Intervention	2022-08-15	<NULL>	<NULL>	5550	Comparison of pain levels in nasopalatine nerve blocks using two different techniques	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2014-06-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9h2kdm9	<NULL>	Both genders; age between 18 and 30 years; any ethnicity; any marital status; any nationality; any place of birth; with previous experience of local anesthesia without intercurrences; not having undergone infiltrative anesthesia in the region in the two weeks prior to the study; and not having used any medication capable of altering pain perception in the two weeks prior to the study	Age lower than 18 years or higher than 30 years old; pregnant or lactating women; history of hypersensitivity to the drugs used in the study; alcohol abuse or drug dependence; psychiatric disorders or systemic diseases; being under treatment with CNS-acting drugs; use of drugs capable of altering pain perception in the two weeks preceding the study; and moderate anxiety or higher (over 9), based on Corah&apos;s Dental Anxiety Scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-10v4dxgm	Transcranial Direct Current Stimulation and Physical Exercise on interlimb coordination, cortical activity and gait parameters in individuals with Parkinson&apos;s disease	Not yet recruiting	Intervention	2022-08-15	<NULL>	<NULL>	5551	Effects of Transcranial Direct Current Stimulation combined with Physical Exercise on individuals with Parkinsons disease locomtion and cortical activity	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-20	Universidade Estadual Paulista Júlio de Mesquita Filho	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-10v4dxgm	<NULL>	Individuals aged 60 or over will be included; both genders; diagnosed with idiopathic Parkinsons disease, based on criteria determined by the London Brain Bank	Participants with a stage greater than 3 on the Hoehn &amp; Yahr scale; insanity; history of orthopedic and vision problems that make it impossible to comply with the experimental protocol; patients at risk of receivingtranscranial direct current stimulation (neural implants, pacemakers, history of seizures and epilepsy)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-79q47nj	Effects on pain reduction of the use of Ibuprofen/Oxycodone versus Ibuprofen/Acetominophen in lower wisdom tooth Extraction Surgery: a comparative study	Recruiting	Intervention	2022-08-15	<NULL>	<NULL>	5553	Analgesic effects of the use of Ibuprofen/Oxycodone versus Ibuprofen/Acetominophen  in lower third molar Extraction Surgery: a comparative study	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-04-11	Universidade Estadual do Rio de Janeiro	Universidade Estadual do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-79q47nj	<NULL>	ASA I, according to American Society of Anesthesiology (ASA) criteria; with the need for bilateral extraction of lower third molars; dental elements that present similarity of positioning; Class 1 and 2 impacted teeth and A and B by Pell and Gregory classifications; non-smokers	History of pericoronitis in the lower third molar region; cystic lesion involving the lower third molar; allergy to any medication prescribed in the postoperative period; any systemic or autoimmune disease; use of other concomitant medications; pregnant patients; lactose intolerant or allergic; surgeries exceeding 40 minutes in duration; smokers volunteers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-9th6k46	Hydrocortisone versus placebo for severe Hospital Pneumonia in ICU patients	Recruiting	Intervention	2022-08-15	<NULL>	<NULL>	5996	Hydrocortisone versus placebo for severe Hospital-acquired Pneumonia in intensive care patients	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-10-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9th6k46	<NULL>	18 years of age or older; Suspected or confirmed case of bacterial nosocomial pneumonia (including ventilator-associated pneumonia); Intensive Care Unit stay; Signed consent form (by the patient or a legal guardian)	Women who are pregnant, have recently given birth or are breastfeeding; Patients who are moribund or do not have a treatment perspective; Patients with community acquired pneumonia; Patients with other types of pneumonia; Those with pulmonary infiltrates in chest image which are not compatible with bacterial pneumonia; Patients with adrenal insufficiency; Patients who have a condition that demands the use of corticosteroids (acute or chronic); Patients allergic to hydrocortisone; Patients with refractory septic shock (those receiving more than 0,5mcg/kg/min of norepinephrine)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:56
RBR-95m34pp	Effects/Effectiveness of Training of Formal Caregivers on sedentary fifestyle and physical and cognitive function of older adults in nursing homes	Recruitment completed	Intervention	2022-08-12	<NULL>	<NULL>	5546	Effects/Effectiveness of Formal Caregiver Training on sedentary behavior and functionality of older adults in nursing homes	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal do Paraná - Programa de Pós-Graduação em Educação Física	Universidade Federal do Paraná - Programa de Pós-Graduação em Educação Física	https://ensaiosclinicos.gov.br/rg/RBR-95m34pp	<NULL>	Older adults aged 60 years or over; of both sexes; living in a nursing home for three months or more; Formal caregivers working in a nursing homes; of both sexes, of all age groups; working in institutions that consent to this proposal	Individuals with changes in physical capacity due to trauma or muscle disease in a recent history; and/or rehabilitation treatment due this situation; Caregivers with service time in the role of less than 15 days	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-9k4bdds	"Comparison of efficacy and safety between two surgical techniques for correcting eyeglasses errors: small-incision lenticule extraction
(SMILE) and femtolaser-assisted in situ keratomileusis (femtoLASIK)"	Recruitment completed	Intervention	2022-08-12	<NULL>	<NULL>	5547	"Comparison of efficacy and safety between small-incision lenticule extraction
(SMILE) and femtolaser-assisted in situ keratomileusis (femtoLASIK) optimized by
wavefront analysis"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-05-25	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9k4bdds	<NULL>	Inclusion Criteria: Spontaneous participation of the patient in the study; there is no gender preference; age 18 years or older; myopia or compound myopic astigmatism (with spherical equivalent between -1.00D and -8,00D and astigmatism up to 4.00D)	Exclusion Criteria: Diagnosis of any systemic disease such as diabetes, hypertension, rheumatologic conditions and neurological conditions; eye conditions such as dry eye, corneal opacities, central corneal thickness below 480 microns, manifest or suspected corneal ectasia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-2tnnhvg	Use of phenylephrine to prevent blood pressure drop in pregnant women during cesarean	Recruitment completed	Intervention	2022-08-12	<NULL>	<NULL>	5548	Phenylephrine Infusion for prevention of arterial hypotension in pregnant women undergoing cesarean section	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2020-12-16	Hospital Geral de Cuiabá – Associação de Proteção à Maternidade e à Infância de Cuiabá	Hospital Geral de Cuiabá – Associação de Proteção à Maternidade e à Infância de Cuiabá	https://ensaiosclinicos.gov.br/rg/RBR-2tnnhvg	<NULL>	Healthy pregnant women; older than 18 years; undergoing elective cesarean section under spinal anesthesia who signed a Free and Informed Consent Form	Age less than 18 years; gestational age less than 37 weeks; systemic arterial hypertension and hypertensive disease of pregnancy, defined as a systolic blood pressure greater than 140 mmHg or diastolic blood pressure less than 90 mmHg; twinning; intrauterine growth retardation; New York Heart Association class II major cardiovascular disease; cerebrovascular disease, fetal abnormality and contraindications to spinal anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-5pw6crc	Effects of exercise and chess in decision making of adolescents	Recruitment completed	Intervention	2022-08-12	<NULL>	<NULL>	5549	Effects of aerobic exercise and chess in executive function of adolescents: a randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-5pw6crc	<NULL>	Sedentary (without regular physical activity for the last six months); wanting to learn how to play chess; avaliability to participate in the evaluations and interventions.	motor impairment or stroke; presenting neurological diseases that interfere in cognition and/or mobility.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-7tvbt4v	Comparison of feeding transition time in premature newborns exposed to Speech Therapy.	Not yet recruiting	Intervention	2022-08-11	<NULL>	<NULL>	5544	Comparative analysis of the food transition process of premature newborns after the application of Speech Therapy Intervention Programs	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-23	Irmandade da Santa Casa de Misericórdia de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-7tvbt4v	<NULL>	Newborns conceived, with a gestational age of 37 weeks according to the corrected gestational age; preterm newborn who have not yet started offering oral feeding	Presence of genetic syndromes congenital malformations of the head and neck or central nervous system; neurological disorders; clinical instability at the beginning and throughout the study based on the analysis of the medical team on respiratory and cardiac instability of the newborn; levels saturation below 90%; respiratory rate above 60 or any other intercurrences that make speech-language intervention impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-2rx6k6p	Comparison between methods for blocking the dental occlusion during surgeries for fixation of facial fractures	Recruitment completed	Intervention	2022-08-11	<NULL>	<NULL>	5545	Comparison between intermaxillary fixation methods in maxillofacial fractures	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-28	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Santa Casa de Caridade de Diamantina	https://ensaiosclinicos.gov.br/rg/RBR-2rx6k6p	<NULL>	Patients diagnosed with facial fractures involving dental occlusion requiring IMF admitted at Santa Casa de Caridade de Diamantina; patients older than 18 years old; healthy patients according to their medical history and physical examination.	Patients diagnosed with complex facial fractures that it would be impossible to evaluate the variables/outcomes; patients with metabolic diseases; toothless patients or those lacking 5 or more posterior teeth; patients in whom it is not possible to achieve intraoperative dental occlusion; patients with history of previous mandibular  fractures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-7y24t7t	Assessment of heart rate variability and body composition in the elderly undergoing Exercise and Gametherapy	Not yet recruiting	Intervention	2022-08-11	<NULL>	<NULL>	5593	Evaluation of autonomic cardiac modulation and body composition in elderly submitted to the Protocol of exercise and the Gametherapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Sáskia Fürstenberg Thoma	Unifacisa- Centro Universitário	https://ensaiosclinicos.gov.br/rg/RBR-7y24t7t	<NULL>	Active elderly people who do physical activity according to the IPAQ (short form) will be included, a questionnaire that aims to carry out a global survey of the prevalence of physical activity in the world (MATSUDO et al, 2001) (ANNEX B). They must be elderly people over 60 years of age who live in the city of Campina Grande-PB and/or adjacent cities, due to the ease of accessibility to the services offered; that have means of transportation that allow their transport to the collection site, as this is an elderly sample group, those who are unable to move will be under the responsibility of the researcher to transport them; those elderly with chronic degenerative diseases may also be included, if they are under drug control.	Exclusion criteria will be those who present disabling pathologies for performing aerobic activities (cardiopathies and decompensated respiratory pathologies), they will be excluded because the protocol requires a satisfactory level of cardiorespiratory resistance to perform the activities proposed by the protocol; those elderly who have musculoskeletal disorders that prevent them from participating in the collection and/or who make use of gait devices since the exercises require large amplitude movements, those who are over 80 years old also do not participate, thinking they have a risk that overcome the benefit and elderly people who are performing other aerobic or anaerobic activities so as not to interfere with the evidence of the results	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-8nkqvw4	Evaluation of irritability and sensitization of a skin cream, through the Contact Test	Not yet recruiting	Intervention	2022-08-10	<NULL>	<NULL>	5541	Evaluation of primary, accumulated dermal irritability and sensitization of a cream, through the Patch Test_TCI01.2022	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-26	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	TCI Biotecnologia Ltda	https://ensaiosclinicos.gov.br/rg/RBR-8nkqvw4	<NULL>	Male and female; Age: 18 to 65 years; Phototype: I to IV; Whole skin of the area	Participants who refuse to participate in the study in question; Revision marks and experimental area that interfere in the evaluation of reactions of reactions; Active dermatoses (local and disseminated) that may interfere with the study results; Pregnant or lactating women; History of drugs for allergic reactions, purchases or products of sensations of intense and topical use: Volunteers with a history of allergies to the material used in the study; Atopy history; Use of vaginal cream; Participants with a history of allergies and products in the category tested; Recent gynecological surgeries; discharges; History of pathologies aggravated or triggered by ultraviolet radiation; Immunodeficiency carriers; Kidney, heart or liver transplants; Forecast of intense sun exposure or tanning session during the period conducting the study; Forecast to take a bath in the sea, swimming pool or sauna during the study; Participants who play sports; Use of the following systemic topical drugs: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to two weeks before selection; Treatment with acidic vitamin A and/or its oral or topical delivery up to 1 month before the start of the study; Forecast before carrying out study 03; Any condition not mentioned above that may, in the opinion of the investigator, carry out an evaluation of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-9586tdy	Efficacy of Ozone Treatment in Patients with Circulatory Disease (in the veins) and Leg Wounds	Not yet recruiting	Intervention	2022-08-10	<NULL>	<NULL>	5542	Evaluation of the Efficacy of Ozone Therapy Applied to the Treatment of Venous Ulcers: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9586tdy	<NULL>	Patients over 18 years of age; Both sexes; Confirmed medical diagnosis of venous insufficiency recorded in the patient&apos;s medical record and confirmed by USG doppler of the lower limbs; Presence of pedal and tibial pulses after palpation in the lower limbs	Patients with infectious and contagious disease; Chronic use of corticosteroids; Bedridden or wheelchair; Diabetics; Pregnant women; Patients who show signs of allergy to any of the components of the Unna Boot; Infection in the ulcer bed; Low adherence: Irregularities in the frequency of visits to consultations (Missing 3 times without justification) or discontinuity in the use of the products	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-6254jmy	The effect of Virtual Reality to aid Peripheral Venipuncture in children	Recruiting	Intervention	2022-08-10	<NULL>	<NULL>	5543	Effectiveness of Virtual Reality in the success of Peripheral Intravenous Catheterization in children: clinical, randomized and controlled study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-03	Universidade Federal de Santa Catarina	Hospital Infantil Dr Jeser Amarante Faria	https://ensaiosclinicos.gov.br/rg/RBR-6254jmy	<NULL>	4 to 15 years old, both genders; elective indication of venopuncture with catheter over needle; be aware; stable clinical or surgical conditions	cognitive deficit; diseases that affect pain sensitivity such as defects in neural tube formation; need for contact precautions; history of seizures; severe dehydration	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:11
RBR-5yjdxvn	Profile and associated symptoms of the patient with head and neck cancer	Recruitment completed	Observational	2022-08-09	<NULL>	<NULL>	5535	Sociodemographic profile of patients with head and neck cancer in southeastern Brazil and associated symptoms	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-04-03	Universidade de São Paulo - Campus Bauru	Universidade de São Paulo - Campus Bauru	https://ensaiosclinicos.gov.br/rg/RBR-5yjdxvn	<NULL>	Patients diagnosed with head and neck cancer; over 18 years of age; in dental treatment at the Faculty of Dentistry of Bauru University of Sao Paulo Clinical Research Center; who agreed to participate in the study and signed the informed consent form	Individuals who did not accept to participate in the research or who had neurological disorders and or cognitive deficits	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-967k5py	Assessment of the effectiveness of cognitive rehabilitation as a therapeutic strategy for patients diagnosed with COVID19 and cognitive symptoms	Recruiting	Intervention	2022-08-09	<NULL>	<NULL>	5536	Clinical trial on the effect of cognitive rehabilitation in individuals with COVID-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-967k5py	<NULL>	Participants residing in Juiz de Fora (MG) with a confirmed diagnosis of COVID-19 by PCR within a period of up to six months before inclusion in the study; over 18 years of age; and literate (enough to guarantee the reading of words or phrases in the execution of the cognitive tests).	Participants who present a neurological and/or psychiatric diagnosis that justify previous impairments or that make it impossible to adhere to and understand the cognitive assessment tasks.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-7w8b4rd	Effect of Coenzyme Q10 (CoQ10) supplementation in rehabilitation and palliative care patients in the Home Care Service of a city in the interior of Minas Gerais	Recruitment completed	Intervention	2022-08-09	<NULL>	<NULL>	5537	Coenzyme Q10 (CoQ10) or Ubiquinone supplementation in rehabilitation and palliative care patients in the Home Care Service of a city in the interior of Minas Gerais	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-06	Priscila Evangelista de Melo	Universidade De Franca	https://ensaiosclinicos.gov.br/rg/RBR-7w8b4rd	<NULL>	Volunteers of both genders should be included in the present study; age over 18 with no maximum age limit; who are in the process of illness in rehabilitation; or in oncological palliative care; or in non-cancer palliative care; in any AD1 home care classification; AD2 or AD3; when they are in palliative care, they should be classified by the Palliative Performance Scale from 20% onwards; able to answer fatigue questionnaires; able to answer the quality of life questionnaire proposed in this study; with trunk control that allows sitting; ability to perform the physical strength test using a dynamometer	Volunteers under 18 years of age should be excluded from the present study; in terminal stage of life; insanity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-44c79db	Risk factors for new asthma attacks in a low-income population	Recruiting	Observational	2022-08-09	<NULL>	<NULL>	5539	ATTACK II Study - Risk factors for recurrence of asthma attacks in a low-income population: a cohort study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-27	Associacao ProAR	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-44c79db	<NULL>	Attendance at public emergency service in the City of Salvador due to an asthma attack 15 days before; Age greater than or equal to 12 years, without distinction of sex; Live in the city of Salvador, Bahia	Pregnant women at the time of inclusion; Patients with impaired understanding and verbal communication; Be participating or have participated in a clinical trial; Diagnosis of comorbidities that make it difficult to assess asthma: other respiratory diseases, history of cerebrovascular accident (CVA), neurological disease, congestive heart failure (CHF), myopathies, psychiatric diseases and advanced neoplasia; History of smoking greater than or equal to 10 packs per year; No landline or mobile phone.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-4yk4hg7	Assessment of hand blood circulation during sitting and its relationship with diseases in patients with more than one type of infection	Recruiting	Observational	2022-08-08	<NULL>	<NULL>	5534	Evaluation of the Perfusional Response to Semi-orthostasis and its relationship to organic dysfunctions in patients with Sepsis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-02-09	Lilian Barth Guimarães	Igor Alexandre Cortês de Menezes	https://ensaiosclinicos.gov.br/rg/RBR-4yk4hg7	<NULL>	Individuals aged over 18 years; of both sexes; In group A are septic patients; diagnosed within 24 hours; In Group B are Intensive Care Unit Workers; Group C are critically ill individuals, but not septic	Pregnancy;High risk of death in less than 24 hours; Patients on mechanical ventilation; Severe obstructive arteriopathy; Clinical contraindication to positional mobilization in bed (eg fracture) Patient refusal to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-876w38c	Effect of Propolis in patients with Angina	Recruiting	Intervention	2022-08-08	<NULL>	<NULL>	6054	Effect of Green Propolis Extract (EPP-AF) in patients with Chronic Stable Angina. A randomized, blinded pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Hospital Ana Nery	Hospital Ana Nery	https://ensaiosclinicos.gov.br/rg/RBR-876w38c	<NULL>	Patients older than 18 years; with stable coronary artery disease (CAD) symptomatic of angina despite optimized clinical treatment for at least four weeks with antianginal drugs (beta-blockers; calcium channel blockers; nitrates and/or trimetazidine)	Patients scheduled for surgical or percutaneous myocardial revascularization within the next 30 days; patients with obstruction of the left main coronary artery greater than 50%; patients who had acute coronary syndrome in the last two months; electrocardiogram at rest with left bundle branch block (LBBB), Wolff-Parkinson White (WPW), pacemaker rhythm, ST-segment depression more than 1mm, digitalis therapy; patients who have some physical limitation that make it impossible to perform the exercise test on a treadmill; heart failure with symptomatic reduced ejection fraction NYHA III-IV	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-2mzhmj2	Impact of icodextrin on the left ventricular hypertrophy in patients with chronic kidney disease on peritoneal dialysis	Terminated	Intervention	2022-08-05	<NULL>	<NULL>	5532	Impact of icodextrin on the left ventricular hypertrophy in patients with chronic kidney disease on peritoneal dialysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2016-11-01	Hospital das Clinicas da Universidade de Sao Paulo	Hospital Sao Paulo - UNIFESP	https://ensaiosclinicos.gov.br/rg/RBR-2mzhmj2	<NULL>	Adult patients with end-stage renal disease on peritoneal dialysis for at least 30 days	Recent hospitalization due to infection (less than 30 days); active cancer; grade 4 or 3 congestive heart failure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-7s99ksf	Use of mesenchymal stromal cells for Graft-versus-host disease after stem cell transplantation	Terminated	Intervention	2022-08-05	<NULL>	<NULL>	5533	Use of mesenchymal stromal cells for Steroid-refractory chronic Graft-versus-host Disease after hematopoietic stem cell transplantation	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2015-04-27	Hospital de Clínicas da Universidade Federal do Paraná - HCUFPR	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7s99ksf	<NULL>	"Age from zero to 70 years; patients (or their parents) who agree to participate in this study and who sign the informed consent form; patients after allogeneic hematopoietic stem cell transplantation;
classic chronic Graft-versus-host Disease or overlap syndrome, refractory to corticosteroid and calcineurin inhibitor treatment and/or interleukin 2 inhibitors. The refractory criteria will be worsening in three days, no improvement in seven days after the beginning of corticosteroid therapy, or no improvement after 21 days of the beginning of interleukin 2 inhibitors"	Patients who have any concomitant clinical condition that contraindicates the infusion of mesenchymal stem cells, in the physician&apos;s opinion; patient with respiratory failure requiring mechanical ventilation; patients with relapsed malignant disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-7dqyscg	Use of computerized anesthesia in children during dental care: A randomized clinical trial to assess anxiety and pain perception	Recruiting	Intervention	2022-08-05	<NULL>	<NULL>	7944	Use of computerized anesthesia in children&apos;s anxiety and pain perception during dental care: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-7dqyscg	<NULL>	Children of both gender; between 7 and 11 years of age; good general health; need for dental treatment under local anesthesia	Children with physical disabilities that prevent the use of computerized anesthesia; mental disability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:38
RBR-22x44mp	Heat monitoring of trapezius muscle trigger points during Application of Dry Needling and Manual Compression	Recruitment completed	Intervention	2022-08-04	<NULL>	<NULL>	5530	Thermonitoring of trapezius muscle Trigger Points during Dryneedling and Ischemic compression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-10	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-22x44mp	<NULL>	both sexes; between 18 and 35 years of age; with at least one active hypersensitive TP in the trapezius and scapular levator muscles; pain on palpation equal to or greater than 3 on the VAS scale; non-smokers; body mass index (BMI) less than 30.0kg/m2; who do not have cardiovascular, infectious, dermatological, and degenerative diseases that interfere with body temperature; are not taking analgesic drugs or drugs that alter body thermogenesis; do not present during the physical evaluation any scar or tattoo in the cervical and thoracic region; are not undergoing physiotherapeutic treatment; and have agreed to participate in the research	who have any complications during the application of the experimental protocol; who withdraw from the experimental procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-6mjd8bx	Oral minoxidil 2.5 mg versus 5 mg for the treatment of male Pattern Hair Loss: a double-blind randomized clinical trial	Recruiting	Intervention	2022-08-03	<NULL>	<NULL>	5529	Oral minoxidil 2.5 mg versus 5 mg for the treatment of male Androgenetic Alopecia: a double-blind randomized clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-08-01	Faculdade de Medicina de Botucatu	Hospital das Clínicas de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6mjd8bx	<NULL>	male; aged between 25 and 55 years; diagnosis of androgenetic alopecia; classified on the Norwood Hamilton scale as 3V, 4V or 5V; agreeing to participate in the research	previous treatment for hair loss in the last 4 months; hypertensive patients; patients with heart disease; nephropathy; hepatopathy; patients with pheochromocytoma; patients with other causes of hair loss or scalp dermatoses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-8c5cjmg	Effects of a Brain Reprocessing Psychotherapy in treating Obesity in adolescents: a quali-quantitative approach	Data analysis completed	Intervention	2022-08-03	<NULL>	<NULL>	7174	Effects of Brainspotting in treating Obesity in adolescents: a quali-quantitative approach	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8c5cjmg	<NULL>	Adolescents with exogenous obesity; Body Mass Index (BMI) z score &gt;2; both genders; aged between 10 and 19 years old; followed up by obesity ambulatory at Nutrology Discipline of São Paulo Federal University’s pediatrich department	Adolescents with pathology that causes difficulties of comprehension, difficulties of reasoning and cognitive deficit; cardiac, neurologichal and psychiatric patologies diagnosis in wich is not recommended the intervation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:11
RBR-7nx3kwp	Effect of a dental floss impregnated with chlorhexidine in adults with Gingivitis	Recruiting	Intervention	2022-08-02	<NULL>	<NULL>	5527	Efficacy of a dental floss impregnated with chlorhexidine in adults individuals with gingivitis: a randomized controlled clinical trial	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-02-18	Universidade Federal de Pelotas	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-7nx3kwp	<NULL>	Men and women at least 18 years of age; avaliable to participate in all phases of the study; good general systemic health; have at least 20 natural teeth present, with the exception of third molars; contiguous interproximal spaces with indication for flossing; have a diagnosis of biofilm-induced gingivitis, with the presence of bleeding gingival in at least 10 percent of the sites examined; being right-handed	Individuals with moderate periodontitis according to the criteria Eke et al 2012, defined as at least two interproximal sites with attachment loss of at least 4mm not on the same tooth or at least two interproximal sites with a depth of probing of at least 5mm not in the same tooth; individuals with severe periodontitis according to the criteria of Eke et al. 2012, defined as at least one interproximal site with probing depth of at least 5 mm and at least 6 mm attachment loss, in at least two interproximal sites, indistinct teeth; individuals who smoke or who have quit smoking for less than one year; individuals with the presence of biofilm retentive factors, except calculus supragingival; those who used systemic antibiotics in the three months prior to the carrying out the study; carriers of any systemic changes, such as diabetes and hormonal disorders with periodontal repercussions; individuals who need to use antimicrobial chemoprophylaxis to receive dental treatment; have undergone periodontal treatment in the last six months; have used chlorhexidine in the last three months; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-8js7t83	Ingestion of probiotics (a Lactobacillus rhamnosus formula) as complementary therapy in the treatment of patients with plaque psoriasis (an inflammatory disease of the skin)	Data analysis completed	Intervention	2022-08-02	<NULL>	<NULL>	5528	Use of a Lactobacillus rhamnosus formula as adjuvant in the treatment of plaque psoriasis patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-20	Enrico Stefano Suriano	Faculdade de Ciências Médicas da Santa Casa de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8js7t83	<NULL>	Being over 18 years old; having plaque psoriasis.	Being pregnant; having other skin diseases, neoplasms or systemic inflammatory diseases (such as Crohn’s disease, inflammatory bowel disease, vasculitis and sarcoidosis).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-463yhb3	Effect of a multimodal physiotherapy intervention to target balance capacity in Huntington s disease a double blind randomized clinical trial	Recruitment completed	Intervention	2022-08-01	<NULL>	<NULL>	5522	Effect of multimodal training with rhythmic cues in Huntington&apos;s Disease a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-12-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-463yhb3	<NULL>	Diagnosis of Huntington&apos;s Disease and confirmed by genetic test showing trinucleotide repeat number above 39; History of balance and gait impairments; and able to walk 10 minutes continuously and independently or with supervision indoors without walking aid	Mini-Mental Status Examination MMSE below 15 points; unstable medication over the past 3 months; and  hearing or visual problems interfering with the tests or training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-10tk7c76	Opioid-free anesthesia compared to standard anesthesia for bariatric surgery: clinical trial	Recruiting	Intervention	2022-08-01	<NULL>	<NULL>	5523	Opioid-free anesthesia compared to opioid-based anesthesia for laparoscopic gastroplasty: a prospective, randomized, double-blind clinical trial	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-08-01	Complexo Hospitalar Santa Genoveva	Complexo Hospitalar Santa Genoveva	https://ensaiosclinicos.gov.br/rg/RBR-10tk7c76	<NULL>	Patients included in the study protocol must meet the following prerequisites: age between 18 and 65 years; with a Body Mass Index (BMI) higher than 40 kg/m2 regardless of the presence of comorbidities or a BMI between 35 and 39.9 kg/ m2 in the presence of comorbidities; classified in the physical status ASA (American Society of Anaesthesiologists) of II or III; patients undergoing laparoscopic gastroplasty surgery under general anesthesia; expected hospital stay of up to 36 hours.	Patients who refuse to participate in the proposed study; patients who are younger than 18 and older than 65 years; who have a BMI (body mass index) lower than 35 kg/m2 or a BMI between 35 and 40 kg/m2 without comorbidities; patients who report adverse reactions to any drug included in the study; patients who have a history of alcohol or illicit substance abuse or chronic use of opioids for various reasons; patients who report liver or kidney failure; patients who have coexisting diseases that impair cognitive ability, such as poorly controlled psychiatric illnesses or neuropsychomotor developmental delay.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-45wvfcr	Nursing Care to improve blood pressure levels in people with Hypertension in the family health strategy	Recruitment completed	Intervention	2022-08-01	<NULL>	<NULL>	5524	The effectiveness of Nursing Care in improving blood pressure control in people with Hypertension in the family health strategy: a cluster-type randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Mestrado Profissional em Saúde da Família no Nordeste	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-45wvfcr	<NULL>	Users diagnosed with arterial hypertension for at least 6 months, be registered in the study FHS; be at least 18 years of age; preserved cognitive and auditory capacity; availability to participate in nursing consultations; both genders	Being pregnant; have chronic complications such as: bedridden elderly, patients with advanced Alzheimer&apos;s or mental disability attested by a health report	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-10m9tg2r	A pilot randomised controlled trial of an Acceptance and Commitment Therapy group intervention for family carers of people with dementia	Recruiting	Intervention	2022-08-01	<NULL>	<NULL>	5525	Family Carers of people with dementia: assessing the efficacy of an Acceptance and Commitment Therapy group intervention	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-10	Universidade Federal de Minas Gerais	University of East Anglia	https://ensaiosclinicos.gov.br/rg/RBR-10m9tg2r	<NULL>	Be a family carer of a relative with a clinical diagnosis of dementia; aged 18 and over; identifying oneself as a primary carer in their family; providing a minimum of 28 hours of care each week; having a minimum of four years of formal education; having access to the internet and a device to access online sessions; scoring nine or higher on the Generalised Anxiety Disorder (GAD-7) questionnaire.	Currently receiving psychological therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-7cr9yvf	Development of CAR-T cells to treat malignant B neoplasms	Not yet recruiting	Intervention	2022-07-30	<NULL>	<NULL>	5519	Development of car-t cell for B malignacies treatment - Phase I clinical trial with autologous T cell genetically modified to express chimeric antigen receptor (car) to treat refractory or relapsed patients with B neoplasm CD19+	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2022-09-01	Hospital Israelita Albert Einstein	Hospital Israelita Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-7cr9yvf	<NULL>	Provision of the dated and signed free and informed consent form (IC); express willingness to comply with all study procedures and availability during the study; men or women; age 02 and 70 years; Good general health, proven by medical history; diagnosis of refractory or recurrent ALL or LLC and non-Hodgkin lymphoma; Ability to administer oral medications; for women with reproductive potential: use of highly effective contraceptive for at least 1 month before screening and agree to use a contraceptive method during participation in the study and for an additional 4 months after the completion of the administration of CAR T cells; for men with reproductive potential: use of condoms or other methods to ensure effective contraception with the partner; Agreement to adhere to Lifestyle Recommendations: Women of childbearing potential, defined as all women physiologically capable of becoming pregnant, must use highly effective contraceptive methods at least 4 months after the infusion of CAR-T; Sexually active men must use a condom during sexual intercourse from the moment the project is signed for at least 4 months after the infusion of CAR-T. A condom is required for all sexually active male participants to prevent them from having a child and to prevent delivery of the study treatment via the seminal fluid to their partner. In addition, participants must not donate sperm. The subjects should attend the consultations, do the tests according to the protocol, use antibiotics and other medications as indicated. Individuals must have ALL, LLC or relapsed or refractory lymphoma treated with at least two lines of treatment. The disease must have progressed or show partial remission or the complete response must not have been achieved with the last regimen; individuals with Philadelphia Chromosome positive acute lymphoblastic leukemia (ALL + Ph) are eligible if they have progressed, have a stable or recurrent disease after two lines of treatment, including tyrosine kinase inhibitors (TKIs); Individuals with LNHDGCB (large B-cell non-Hodgkin&apos;s lymphoma) must have progressed, presented with stable disease or recurrence after initial treatment regimens that include an anthracycline and an anti-CD20 monoclonal antibody; Individuals with transformed LF (follicular lymphoma), LZM (mantle zone lymphoma) or LLC / ALL must have progressed, presented with stable disease or recurrence with transformed disease after initial treatment for LNHDCGB; Individuals who had a recurrence ≥12 months after treatment must have progressed after autologous transplantation or be ineligible for autologous transplantation; The patient&apos;s disease must be positive for CD19 by immunohistochemistry or flow cytometry analysis in the last available analysis; 2 to 70 years of age; General status: Adult individuals: ECOG less than or equal 2 for individuals over 16 years old; Lansky greater than or equal to 50% for individuals under 16 years old; Normal Functioning of Organs and Marrow (supportive treatment is allowed according to institutional rules, that is, filgrastim, transfusion): Total bilirubin ≤ 2; AST (TGO) ≤ 5 times the normal limit; ALT (TGP) ≤ 5 times the normal limit; Serum Creatinine ≤ 1.5; Pulse oximetry&gt; 91% in room air; Absence of dyspnea or mild dyspnoea (≤ Grade 1); Forced expiratory volume in 1 s (FEV1) ≥50% or carbon monoxide diffusion test (DLCO) ≥50% of the predicted level; Left ventricular ejection fraction ≥45% confirmed by echocardiogram; individuals must have the following parameters of hematological function: Neutrophil&gt; 1000 / ul; Absolute Lymphocyte Count&gt; 100 / ul; Platelets&gt; 50,000 / ul; Patient should not be excluded if the above parameters are changed due to infiltration of spinal disease; Elimination of prior treatment: At least 2 weeks or 5 half-lives, whichever is longer, must have elapsed since any previous systemic therapy at the time that leukapheresis is planned for the individual, except systemic inhibitory checkpoint therapy / immunostimulant, which requires 5 half-lives. Patient with previous treatment with blinatumumab, at least 4 months after the last application; Individuals must be able to understand in order to be willing to sign an informed consent form.	Autologous transplantation within 6 weeks of the planned infusion of CAR T cells; history of allogeneic stem cell transplantation of hematopoietic stem cells (HSCT) 4 months before the infusion; receiving treatment with CAR T cells outside this protocol; compromise of the active central or meningeal system by tumor. Individuals with untreated brain metastases / CNS disease will be excluded from this clinical study because of their unfavorable prognosis and because they often develop progressive neurological dysfunction that would confuse the assessment of neurological and other adverse events. Patients with a history of CNS or meningeal involvement should be in documented remission by assessing cerebrospinal fluid and contrast-enhanced MRI for at least 90 days before registration; history of active malignancy, other than non-melanoma skin cancer, carcinoma in situ (eg, cervical, bladder, breast); HIV infection; HTLV; individuals with uncontrolled intercurrent disease, among others, existing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, lung abnormalities or psychiatric diseases / social situations that would limit compliance with the requirements of the study; pregnant or lactating women are excluded from this study, as treatment with CAR T cells may be associated with the potential for teratogenic or abortion effects. Fertile women must have a negative serum pregnancy test result. As there is an unknown but possible risk of adverse events in infants secondary to the mother&apos;s treatment with CAR T cells, breastfeeding should be discontinued. These possible risks can also be applied to other agents used in this study. Fertile individuals must be willing to use contraceptives from admission to this study and for 4 (four) months after receiving the preparatory regime; evidence of myelodysplasia or cytogenetic abnormality indicative of myelodysplasia in any bone marrow biopsy before the start of treatment; serological status reflecting active hepatitis B or C infection. Patients who test positive for hepatitis B core antibody, hepatitis B surface antigen (HBsAg), or hepatitis C antibody must have a negative polymerase chain reaction (PCR) result prior to admission. (patients with a positive PCR result will be excluded); serious and / or potentially fatal medical conditions; patients with a clinical history of pathology in the relevant central nervous system such as epilepsy, convulsive diseases, paresis, aphasia, severe brain injury, dementia and Parkinson&apos;s disease; history of autoimmune disease (such as rheumatoid arthritis, systemic lupus erythematosus) in need of immunosuppressive medication in the last 12 months; history of severe hypersensitivity to one of the agents used in the study; creatinine level below 30 ml / min	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-75zt25z	Influence of human enzyme gene variations on the effects of peppermint essential oil supplementation on physical performance of runners	Recruiting	Intervention	2022-07-30	<NULL>	<NULL>	5521	Influence of the ACE gene polymorphism on the effects of peppermint (Mentha piperita L.) essential oil supplementation on the physical performance of runners	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-10-01	Federal University of Paraíba	Federal University of Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-75zt25z	<NULL>	As inclusion criteria, athletes must have at least one year of training, with a weekly frequency of five training sessions, of which at least three must be running, weekly training volume of at least 50km covered, and have been training for some competition for at least four months of uninterrupted season.	Will be excluded from the study volunteers who change the usual pattern of eating or exercise training during the study period, do not consume the amount of peppermint essential oil-based drink or controls provided, present gastrointestinal intolerance and do not participate in all the experimental procedures. If they have any recognized chronic-degenerative disease, be smokers and make continuous use of any medication. In addition, if you are in the habit of regularly consuming mint and its derivatives, as well as any alcoholic beverage, vitamin food supplements or those containing the active substances present in peppermint (polyphenols, flavonoids, carotenes and menthol).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-897tzz6	Evaluation of the safety and efficacy of using the mint-flavored denture fixative cream product through Acceptability Assessment in the oral cavity	Not yet recruiting	Observational	2022-07-29	<NULL>	<NULL>	5517	Clinical study to evaluate the safety of the investigational product mint-flavored denture fixative cream through the Assessment of Acceptability in the oral mucosa and Perceived Efficacy under normal conditions of use	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-05	Kosmoscience Ciência e Tecnologia Cosmética Limitada	Cimed Industria Sociedade Anônima	https://ensaiosclinicos.gov.br/rg/RBR-897tzz6	<NULL>	Age range between 18 and 60 years. Female and male. Phototype (Fitzpatrick): I to VI. Being a user of removable dental prostheses (dentures). Be a user of products of the same category. Agree on procedures and requirements during study use: study time (after 21 days) laboratory to perform investigational product home study procedures, change the product study diary, do not change the study product study diary. Agree to perform facial aesthetic dermatological treatments until the end of the study (21 days), such as: peelings, laser, fillers, use of any unusual suitable products	Pregnant or lactating women. Participant who belongs to the risk group for COVID-19, that is, with cardiovascular, renal and chronic respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group. Presence of dermatoses, active skin lesions (local and/or disseminated) or irritation in the mouth region (internal or external). Expected vaccination during the study or up to 3 weeks before the study. History of oral pathologies. Use of non-steroidal anti-inflammatory drugs, corticosteroids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study. Be participating in another study in the same application region. History of non-adherence or unwillingness to adhere to the study protocol. Being undergoing dental treatment. Not taking vitamin A or derivatives. Any condition that, in the opinion of the researcher, could compromise the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-325mxv6	Electromyographic evaluations of the muscles of the head, associated with the bite force test and the quality of life and perception questionnaires, before, during and after the rehabilitation of patients with complete dentures	Recruitment completed	Intervention	2022-07-28	<NULL>	<NULL>	5513	Electromyographic evaluations of the masseter, temporal and orbicularis oris muscles, associated with the bite force test and quality of life (oral health impact profile) and perception questionnaires, before, during and after the rehabilitation of patients with complete dentures	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2018-06-21	Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot; - Faculdade de Odontologia de Araçatuba	"Universidade Estadual Paulista ""Júlio de Mesquita Filho"" - Faculdade de Odontologia de Araçatuba"	https://ensaiosclinicos.gov.br/rg/RBR-325mxv6	<NULL>	Ages 40 to 80 years. Patients ASA (American Society of Anesthesiology) I and ASA II (controlled systemic disease). Participants must be bimaxillary edentulous, have good oral health and good cognitive ability to answer questions and follow commands. Height of the upper bone ridge must be sufficient to retain the old upper complete denture during speech, chewing, swallowing, etc. The height of the lower edge must be randomized. All participants must have a vertical dimension of occlusion reduced by at least 2mm. Acrylic teeth of complete dentures must be worn, to prove that the patient really uses the pair of complete dentures daily. Participants&apos; old complete dentures must have some functionality, that is, they must allow chewing of food, speech, swallowing and clenching of acrylic artificial teeth. Old complete dentures cannot have fractures that make it impossible to use them, or hurt the patient. Not being undershot or overshot. Participants must have healthy mucosa, that is, no signs of inflammation, traumatic injury, candidiasis, or hyperplasia. Each participant must wear the same pair of old acrylic complete dentures (base and acrylic teeth) for at least 5 consecutive years. Absence of temporomandibular disorder confirmed by the  the Research Diagnostic Criteria  questionnaire.	Old complete dentures with porcelain teeth. Patients who required the artificial teeth of their new complete dentures to be porcelain. Patients with osseointegrated dental implants, or who required dental implants. Patients with residual roots. Old complete dentures with reline material. Participants who had xerostomia problems. Participants who used complete denture fixators routinely, as these fixators can influence the masticatory function and patient perception. Alzheimer&apos;s disease. Parkinson&apos;s disease. Immunocompromised patients (eg, human immunodeficiency virus infection). Patients with a history of psychiatric disorders (eg depression), neurological disorders and salivary gland disease. History of oral surgery in the last 3 months. Mandibular and/or maxillary torus. Bucosinusal communication. Orofacial defects or anomalies. Routinely abusive alcohol consumption. Participants with a history of neurological disease, lack of coordination or mental disorders. Use of psychiatric medications that induce bruxism and xerostomia, or medications with some influence on the muscles. Use of illegal drugs. Allergy to polymethylmethacrylate (PMMA). Tumor history, or those undergoing radiotherapy and/or chemotherapy. People who are partially or completely dependent on third-party care. Those uncooperative or unwilling to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-55n74zm	Carotid-Body modulation through Meditation in Hypertensive subjects	Not yet recruiting	Intervention	2022-07-28	<NULL>	<NULL>	5514	Carotid-Body modulation through Meditation in stage-I Hypertensive subjects: study protocol of a  randomized and controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal de Mato Grosso do Sul	Hospital Universitário Maria Aparecida Pedrossian	https://ensaiosclinicos.gov.br/rg/RBR-55n74zm	<NULL>	Subjects of both sexes; aged between 30 and 70 years; patients with arterial hypertension or using at least one antihypertensive medication; stage I systemic arterial hypertension with a minimum diagnosis of 1 year; use of unchanged antihypertensive medication for at least 2 months; did not participate in regular exercise programs 3 or more times a week in the last 3 months prior to the study; are able to read; speak and understand Portuguese	Subjects who do not adhere to the experimental protocol; who have a diagnosis of heart failure greater than or equal to New York Heart Association I; chronic obstructive pulmonary disease; cognitive impairment that makes it impossible to understand the protocols; or psychiatric disease; previous stroke; neuromuscular disease; asthma; uncontrolled diabetes; vascular disease peripheral; obesity grade III; renal failure of stage greater than 2; sleep apnea; malnutrition; or other diseases that interfere with the performance of the protocol; and lack of more than two sessions of supervised meditation; secondary hypertension; individuals with contraindications to performing a symptom-limited maximal exercise test; and individuals who regularly practice meditation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-6qk24v7	Effects of an acupuncture protocol associated with physical exercise for chronic back pain and functional independence in the elderly.	Recruitment completed	Intervention	2022-07-28	<NULL>	<NULL>	5515	Effects of an acupuncture protocol associated with multicomponent physical exercise on chronic low back pain and functional independence in the elderly: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-15	Universidade Comunitaria da Regiao de Chapeco - UNOCHAPECO	Universidade Comunitaria da Regiao de Chapeco - UNOCHAPECO	https://ensaiosclinicos.gov.br/rg/RBR-6qk24v7	<NULL>	elderly, of both sexes, with preserved cognitive status tested by the MMSE. Age between 60 and 85 years. Presence of Chronic Low Back Pain, defined as a complaint of pain in the lumbar region below the 12th thoracic vertebra, with or without radiation, and lasting more than 6 months, with a moderate to severe degree of intensity, tested by the Visual Analogue Pain Scale.	missing two consecutive intervention sessions or three interspersed. underwent acupuncture treatment in the last 6 months. present injuries or neurological disorders that compromise walking and exercise performance. have tumors and are undergoing cancer treatment; have nerve compression caused by spinal pathologies, trauma or tumors; have bone or spinal cord infections and ankylosing spondylitis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-5qyszr9	Assessment of skin irritability	Not yet recruiting	Intervention	2022-07-28	<NULL>	<NULL>	5516	Assessment of primary dermal irritability, accumulated dermal irritability, and dermal sensitization (HRIPT)	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Medicin Instituto da Pele Ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-5qyszr9	<NULL>	Participants of both sexes; age between 18 and 70 years; phototypes: I, II, III and IV (according to the Fitzpatrick adapted scale – Annex 1); intact test region skin; agreement to comply with the trial procedures and to attend the clinic on the days and times determined for the medical evaluations and for the application and reading of the dressings, understanding, consent and signing the Free and Informed Consent Form (FICT)	Participants who have been diagnosed with COVID-19 in the last 4 weeks or who have symptoms such as fever, dry cough, tiredness, body aches or other discomforts; pregnancy or risk of pregnancy and/or lactation (when female); use of anti-inflammatory drugs for 30 days and/or immunosuppressants for up to three months before selection; immunosuppression by drugs or active diseases, decompensated endocrinopathies; personal history of atopy; intense sun exposure or tanning sessions up to 15 days before the assessment or during the study period; predicted intense exposure to sunlight or tanning sessions during the study period; forecast of bathing in the sea, swimming pool or sauna during the study; practice of water sports during the study; dermographism; use of oral or topical treatment with vitamin A acid and/or its derivatives up to 1 month before the start of the study; cosmetic and/or dermatological treatment on the body within 3 weeks prior to selection; scheduled vaccination during the study period or up to 3 weeks before selection; history of sensitization and irritation to topical product; active skin pathologies (local and/or disseminated) that could interfere with the study results; use of new drugs and/or cosmetics during the study; skin reactivity; previous participation in studies with the same product; congenital or acquired immunodeficiency; relevant medical history or current evidence of alcohol or other drug abuse; known or suspected history of intolerance to any ingredient in study products (test or comparative products); history of non-adherence or unwillingness to adhere to the study protocol; employees of Medcin or the sponsoring company involved in the study, or a close family member of an employee involved in the study, or other conditions deemed by the researcher to be reasonable for disqualification from participation in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-98ymxqj	Use of Ankle Electrical Stimulation for the treatment of children and adolescents who were born with diseases of the anus and intestine and after corrective surgery who present with intestinal constipation	Recruiting	Intervention	2022-07-27	<NULL>	<NULL>	5512	Clinical evaluation and applicability of posterior tibial nerve transcutaneous electrical stimulation for the treatment of postoperative constipation in children and adolescents with Anorectal Malformation or Hirschsprung Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-18	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-98ymxqj	<NULL>	Age between 7 and 18 years; Both sex; diagnosis of postoperative constipation according to Rome IV criteria; patient in late postoperative correction of anorectal malformations; patient in the late postoperative period of Hirschsprung&apos;s disease; Free and informed consent form and Free and informed consent form (patients between 11 and 18 years old) duly signed	Patients with ostomies; Patients with postoperative strictures; Patients with residual aganglionic follow-up; Neurological and/or cognitive deficits; Skin lesions at the application site; heart diseases; Subjected to medication or food change during the intervention; Patients who drop out of the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-7jtf787	Effects of the Pilates Method and Circuit Training on the motor and cognitive function of the elderly	Recruitment completed	Intervention	2022-07-26	<NULL>	<NULL>	5509	Comparison of the Effects of two types of intervention, Pilates Method and Coordinative Motor Circuits, on variables of motor and cognitive behavior in senior citizens in the São Francisco Valley region: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-03	Universidade Federal do Vale do São Francisco	Universidade Federal do Vale do São Francisco	https://ensaiosclinicos.gov.br/rg/RBR-7jtf787	<NULL>	Age 60 years or older; agree to participate in the study; no exacerbations or debilitating infections in the past three months; no contraindications to testing; not have neuromuscular diseases that present motor deficit, such as Stroke, Multiple Sclerosis, Amyotrophic Lateral Sclerosis or Guillain-Barré.	Accident during training that makes it impossible to continue the program; three consecutive absences in the intervention sessions; total frequency less than 25%; frequent delays that compromise the evolution of training; developing a disease that makes it impossible to exercise; withdrawal; difficulty in understanding the procedures proposed by the researchers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-369svc4	Assessment of sleep quality in athletes of Functional Fitness	Recruiting	Observational	2022-07-26	<NULL>	<NULL>	5510	Assessment of sleep quality in athletes of Functional Fitness	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-02	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-369svc4	<NULL>	Be a male athlete in the Functional Fitness modality with at least 4 months of untrained sports practice, regularly at least 4 months a week;  Be between 18 and 35 years of age; Agree to participate in the signed study and the Free and Informed Consent Form (ICF).	Presence of sleep-associated comorbidities (obstructive sleep apnea, excessive sleepiness disorder, sleep-wake cycle disorders, narcolepsy and cataplexy, sleep disorders, anxiety, depression and obesity) with medical diagnosis and/or drug use (antidepressants) , herbal medicines or those with hormone-like action) for inducing sleep;  Athletes who work at night or have any working condition that affects the assessment of this study;  Athletes using steroids or anabolic peptides;  Withdrawal of the participant at any time in filling in the information regarding the chronotype, daytime sleepiness and sleep quality;  Absence of information or incorrect filling of age; sex; occupation; work shift and/or studies; practice of physical activity that make it impossible to quantify these data.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-106x5n9j	Innovative technologies applied to tuberculosis and HIV surveillance	Not yet recruiting	Intervention	2022-07-26	<NULL>	<NULL>	5511	Innovative technologies applied to tuberculosis and HIV surveillance	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-106x5n9j	<NULL>	Patient over 18 years old with indication for Tuberculosis treatment; patient who has access to a smartphone; patient who agrees to participate in the research	Patients without indication for Tuberculosis treatment; patients deprived of liberty; patients without access to a smartphone; homeless or hospitalized patients; patients with limitations in understanding the application&apos;s commands and their functions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-97ndkq7	Effect of caffeine on weight and physical performance	Data analysis completed	Intervention	2022-07-25	<NULL>	<NULL>	5507	Effect of mouthwash with nutritional products containing caffeine on the immunometabolic profile and physical performance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Faculdade de Nutrição da Universidade Federal de Goiás	Faculdade de Nutrição da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-97ndkq7	<NULL>	Man; physically active; experience with resistance training for at least 2 months; equal or greater than 18 years; availability of time and transportation	Smoker; Illnesses; Inflammatory process; Injury to lower or upper limbs; caffeine allergy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-8mb3ws4	Dental care of critical patients and its influence on the modulation of the oral bacterial microbioma	Data analysis completed	Intervention	2022-07-25	<NULL>	<NULL>	5508	Analysis of the salivary microbiome of critically ill patients and its relationship with nutritional status and antibiotic resistance	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-07	Universidade do Oeste de Santa Catarina	Hospital Unimed de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-8mb3ws4	<NULL>	patients admitted to the Intensive Care Unit; on mechanical ventilation; older than 18 years	patients who had a current diagnosis and/or salivary gland disorders (Sjogren&apos;s syndrome, salivary gland tumor, parotitis); cancer patients regardless of the stage of the disease, psychiatric patients,; postoperative discharge within the first 24 hours; patients admitted from other institutions already on mechanical ventilation and oral and maxillofacial trauma	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-64n2g5h	Pilates methods can cause perineal effects and Exercises in the treatment of perineal dysfunctions in postpartum women: a randomized clinical trial	Not yet recruiting	Intervention	2022-07-22	<NULL>	<NULL>	5505	Effects of the pilates method with floor activation pelvic and Perineal exercises in the treatment of Dysfunctions of the pelvic floor in postpartum women: clinical test randomized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Universidade do Estado do Rio Grande do Norte	Universidade do Estado do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-64n2g5h	<NULL>	Will be included in the present study; women who have given birth within one year; who are in the age group between 18 and 50 years; who have gynecological complaints arising from pelvic floor dysfunctions; who answer yes to at least two of the nine questions asked in the questionnaire during the assessment; and who reside in the city of Quixeré CE	They will be excluded from the present study; women who do not enjoy full mental health to answer the form and/or questionnaire; who have performed any surgical procedure involving the pelvic floor area as well as total or partial hysterectomy and/or perineal surgery; who present pathologies that interfere with the muscle health of the pelvic floor; that sketch pelvic muscle strength equal to or less than grade 1 in the assessment; women who have passed or are going through climacteric; and those who are already or who have been in any type of treatment related to floor dysfunctions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-6myq2rc	Unsupported Upper Limb Exercise test modification and assessment of measure properties in individuals with Chronic Respiratory Diseases and Post Covid 19	Recruiting	Intervention	2022-07-22	<NULL>	<NULL>	5506	Unsupported Upper Limb Exercise test modification and assessment of psychometric properties in individuals with Chronic Respiratory Diseases and Post Covid 19	<NULL>	n/a, single-arm-study, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-02-01	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6myq2rc	<NULL>	Age over 18 years; present a diagnosis of chronic respiratory disease or post covid syndrome 19;  not having been admitted to the hospital in the last month; not present changes in medications; not present increase in respiratory symptoms;  sign the informed consent form and clarify	Cardiac, orthopedic, or neurological conditions that could impair performance during the test; non-optimized clinical drug treatment; inability to give informed consent; inability to understand and or perform the tests proposed for the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-7yh559g	The effect of proprioceptive training on tinnitus, muscle strength and functional capacity in individuals who have sequelae after having had COVID-19: Randomized Clinical Trial	Recruiting	Intervention	2022-07-21	<NULL>	<NULL>	5501	Effect of Proprioceptive Training on Tinnitus, Muscle Strength and Functional Capacity in Individuals with Acute Post-COVID-19 Sequelae: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-10	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7yh559g	<NULL>	Individuals who have been affected by Covid-19 proven by laboratory examination; Be functionally independent; Absence of severe neurological disease, vascular disorder, labyrinthitis and blindness; Patient without severe foot deformity, requiring therapeutic footwear, and in the spine and who do not have orthopedic deficiencies; Do not use mobility aids; No history of fractures in the lower limbs and spine in recent years.	Individuals with COVID-19; have uncontrolled hypertension, that is, systolic blood pressure at rest (˃180 mmHg) and/or diastolic blood pressure at rest (˃110 mmHg); uncontrolled arrhythmia; active myocarditis; signs respiratory distress at rest; oxygen saturation less than 88%; acute systemic illness or fever; resting heart rate less than 50 and greater than 100 beats per minute; nausea; dizziness; shortness of breath and/or severe fatigue; drop in 4% of oxygen saturation in relation to the resting value and values ​​less than 88%; excessive sweating; anxiety crisis; palpitations; pain or tightness in the chest; presents pain during training; Inadequate execution of activities during the intervention procedure; making it impossible to obtain data; Not signing the consent form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-268y2t4	Treatment of dental implant disease	Data analysis completed	Intervention	2022-07-21	<NULL>	<NULL>	5502	Comparative Study of Different Techniques for the treatment of periimplantitis disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-268y2t4	<NULL>	Included patients must have gingival bleeding around the implant, bone loss around the implant and the implant must have been in masticatory function for more than 01 year, patient of both sexes aged between 18 and 80 years, non-smokers, not using of systemic medication and patients should not be pregnant or lactating.	Excluded patients must not present: gingival bleeding around the implant, bone loss around the implant and the implant must not have been in mastication for more than 01 year, aged below 18 years or above 80 years, smokers, with use of systemic medication and pregnant and lactating patients, history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-83rmpc8	Assessment of functionality in post-COVID patients	Recruiting	Intervention	2022-07-21	<NULL>	<NULL>	5503	Functionality in critical post-COVID patients	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal de São Paulo	Instituto do Coração -InCor - HCFMUSP	https://ensaiosclinicos.gov.br/rg/RBR-83rmpc8	<NULL>	Patients diagnosed with COVID-19, Need for invasive or non-invasive ventilatory support for more than 24 hours, Planning for ICU discharge.	Neurological or cognitive damage that compromises the execution of the tests.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-108bctm7	Intra-hospital rehabilitation versus conventional physical therapy in post-intensive care syndrome: a randomized controlled trial	Not yet recruiting	Intervention	2022-07-21	<NULL>	<NULL>	5504	Integrated actions to prevent post-intensive care syndrome and better use of health resources.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-22	Hospital das Clínicas da Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-108bctm7	<NULL>	The following will be eligible for the study: patients over 18 years of age who were discharged from the ICU and who has remained in the ICU for at least 5 days and/or who underwent mechanical ventilation for 72 hours or more; patients diagnosed with ICU-acquired muscle weakness with a Medical Research Council (MRC) score of less than 48/60 in 12 muscle groups or an average MRC of minus 4 per muscle group; be able to understand the proposed protocol; have access to a telephone. Will be included in the study: all patients considered eligible and who sign the free and informed consent form. Consent may be provided and the consent form signed by a family member or caregiver, by mutual agreement, in the impossibility of signature by the participant himself.	Will not be eligible: patients with a survival expectancy of less than six months or who are in palliative care; patients with neurological injury that determines permanent impairment of consciousness, neurodegenerative diseases such as Parkinson&apos;s, Alzheimer&apos;s or previous dementia or that the reason for admission to the ICU is spinal cord injury (SCI), cerebrovascular accident (CVA) and/or neuromuscular disease, such as Guillian -Barré, Myastenya gravis, multiple and/or amyotrophic lateral sclerosis; present unstable fractures in the upper limbs (MMSS), lower limbs (LL) and spine; presence of absolute or relative contraindications for exercise according to the recommendations of the American College of Sports Medicine. Will be excluded: those who withdraw consent after signing the TCLE; patients who for some reason return to the ICU; participants who are unable to perform the protocol and proposed assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-6cyvhxx	Effect of toothbrush head size on teeth cleaning	Recruiting	Intervention	2022-07-20	<NULL>	<NULL>	5497	Efficacy of toothbrushes with different head sizes in removing biofilm and evaluating supragingival inflammatory parameters: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Luterana do Brasil	Universidade Luterana do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-6cyvhxx	<NULL>	Individuals of both sexes; Age between 24 and 65 years; With availability to participate in all experimental periods of the study; With at least 20 natural teeth present; They must not be participating in any other study or research; Patients diagnosed with gingivitis.	Dentistry students; smokers; Individuals with hyperglycemia; Pregnant and lactating women; Individuals with carious lesions and/or root remains in the mouth; Individuals diagnosed with periodontitis. Individuals who use metallic or acrylic removable partial dentures; Individuals who use fixed orthodontic appliances; Individuals who have consumed anti-inflammatory drugs and/or corticosteroids within 3 days of the experimental stage; Subjects who had consumed antibiotics three months before the present study; Individuals who have received dental prophylaxis or periodontal treatment within the last three months. Individuals who need antibiotic prophylaxis prior to dental procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-4c53f3m	Implementation of clinical pharmacy services into Brazilian healthcare system	Recruiting	Intervention	2022-07-20	<NULL>	<NULL>	5498	Implementation and integration of clinical pharmacy services into healthcare systems	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Federal do Espírito Santo	Universidade Federal do Espírito Santo	https://ensaiosclinicos.gov.br/rg/RBR-4c53f3m	<NULL>	Patients with age 18 years or older; diagnosis of Hypertension according to the criteria of the Brazilian Guideline of arterial hypertension; use at least one medication for Hypertension for at least six months;  purchase at least one medication for Hypertension at the community pharmacy in the municipality of Alegre/ES in the last six months.	patients with plans to move from the municipality during the study period; people who do not have autonomy over their health and use of their own medicines; pregnant women, women with the intention of becoming pregnant during the execution of the study and/or lactating women; patients with terminal disease (eg terminal cancer; chronic kidney disease on dialysis); individuals who do not attend three consecutive pharmaceutical consultations; patients treated by other clinical pharmacy services; patients with a history of myocardial infarction or stroke in the last six months; individuals who are participating in other studies that assess impacts of health interventions on cardiovascular parameters and glycemic control.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-5hq9y3k	Development of a nurses&apos; training to improve the perception over patients becoming severely ill	Not yet recruiting	Intervention	2022-07-20	<NULL>	<NULL>	5499	Nurses&apos; training for early clinical deterioration assessment and management	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Estadual de Campinas (Unicamp)	University of Rhode Island	https://ensaiosclinicos.gov.br/rg/RBR-5hq9y3k	<NULL>	All the floor nurses, both genders, allocated to an adult inpatient unit at a University Hospital in the state of São Paulo will be considered eligible	All nurses who are inactive, on leave, and on vacation during the data collection period will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-3v7myyf	Impact of an online exercise program on movement ability, function, pain and fear of movement in women with chronic low back pain	Recruiting	Intervention	2022-07-20	<NULL>	<NULL>	5500	Impact of a telemedicine exercise program on kinetic-functional ability, pain and kinesiophobia in women with chronic lumbar pain: a quasi experimental study	<NULL>	n/a, non-randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-06-07	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-3v7myyf	<NULL>	Have a medical diagnosis of chronic low back pain of mechanical origin. women. not performing any other type of exercise treatment. local pain in the lumbar region. be lucid and able to communicate verbally	Low back pain radiating to the lower limbs. non-literacy. presence of another condition in the musculoskeletal and/or neurological system. congenital spinal alteration or recent vertebral fracture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-835hmdg	Comparison of intervention with conventional exercises and graded exposure for the treatment of shoulder pain	Not yet recruiting	Intervention	2022-07-19	<NULL>	<NULL>	5494	Graded exposure-based approach compared with a strengthening exercises and manual therapy in patients with chronic shoulder pain: a randomized controlled trial with economic evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto - USP	https://ensaiosclinicos.gov.br/rg/RBR-835hmdg	<NULL>	Individuals with shoulder pain in the proximal anterolateral aspect of the shoulder; aggravated by movement; who present symptoms lasting at least three months and who present a minimum score of 50 points on the disability scale (Shoulder Pain and Disability Index)	Individuals with a history of trauma or surgery in the shoulder; total rupture of the rotator cuff and biceps tendon; practitioners of sports-level physical activity involving the upper limbs; individuals with a history of cancer; neurological; cardiac and systemic disorders (rheumatoid arthritis or fibromyalgia) in order not to compromise the study objectives; reproduction of shoulder pain with radiating pain; numbness or tingling in the upper limb as an indication of primary involvement in the cervical or thoracic region; presence of wrist dysfunctions (eg. carpal tunnel syndrome); have undergone physical therapy treatment for the shoulder or any other musculoskeletal condition in the last six months; individuals who have contraindications for physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-2mqbwbd	Acute effects of the application of the foam roller on dorsiflexion and squat performance in extreme conditioning program practitioners: randomized clinical trials.	Terminated	Intervention	2022-07-19	<NULL>	<NULL>	5495	Acute effects of the application of the foam roller on dorsiflexion and squat performance in extreme conditioning program practitioners: randomized clinical trials.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade do Estado de Minas Gerais	Luana Rocha Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2mqbwbd	<NULL>	Men and women between 18 and 45 years old practicing an extreme conditioning program for more than 4 months.	Feeling pain when performing the tests; pregnancy; history of cardiac and/or neurological problems; history of previous injury or surgery in the lower limbs; they have pathologies that affect balance, such as labyrinthitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-366n64w	Stimulating Disfunctional Bowel before Ileostomy Closure	Not yet recruiting	Intervention	2022-07-19	<NULL>	<NULL>	5496	Stimulating Excluded Loop before Ileostomy Closure	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein	https://ensaiosclinicos.gov.br/rg/RBR-366n64w	<NULL>	Adult patients (older than 18 years); with rectal cancer in clinical stages cT3/4Nx or cTxN+; that maybe treated with neoadjuvant chemoradiotherapy; anda submitted to laparoscopic or robotic total mesorectal excision, and submitted to loop protection ileostomy; And also patients who are not undergoing systemic chemotherapy	Patients who refuse to participate in the study; Patients with a history or suspicion of inflammatory bowel disease; Pregnant patients; Patients who have any contraindication for general anesthesia or surgical intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-10m474jv	Effect of photobiomodulation application on neck muscle pain	Not yet recruiting	Intervention	2022-07-18	<NULL>	<NULL>	5492	Effect of photobiomodulation on trapezius myofascial pain: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-15	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-10m474jv	<NULL>	Men or women aged 18 or over; diagnosis of trigger point in the upper trapezius muscle by the diagnostic criteria according to the consensus described in the study by Fernandez-De-Las-Penas and Dommerholt (2018), in which three criteria are established: two manual findings (a tense band and a hypersensitive point) and a symptom (referred pain, with characteristic depth and irradiation), requiring the presence of one of the manual findings and referred pain for the diagnosis to be positive.	neck or shoulder trauma; diseases that contraindicate the use of laser; surgery history; refusal to perform the assessment and intervention after randomization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-5pygzhj	A clinical trial to evaluate the feasibility and efficacy of using Anastrozole before surgery for patients with hormone-related localized Breast Cancer with low proliferative capacity	Recruiting	Intervention	2022-07-18	<NULL>	<NULL>	6414	A phase II single-arm clinical trial to evaluate the feasibility and efficacy of Neoadjuvant Anastrozole in luminal, low proliferative index Breast Cancer patients at TNM stages II and III	<NULL>	2, single-arm-study, open	2	<NULL>	<NULL>	<NULL>	2022-07-20	Hospital de Câncer de Barretos	Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-5pygzhj	<NULL>	"Age 18 years or older; histologically confirmed unilateral primary invasive carcinoma of the breast; 
estrogen receptor positive (Allread ≥6); progesterone receptor positive (any percentage value); HER-2 negative; histological grade according to Scarf-Bloom-Richardson 1 or 2; Ki-67 antigen &lt;50% on immunohistochemistry; TNM staging by 8th Edition cT2-4c cNqq M0; tumor clinically palpable and larger than 2cm on palpation and/or imaging examination; functional capacity assessed by Eastern Cooperative Oncology Group Performance Status (ECOG-PS) of 0 - 2; adequate hematologic, renal, and hepatic function; absence of any psychological, familial, sociological, or geographic condition that would potentially hinder adherence to the study protocol and follow-up schedule; patient agreeent to provide the required research biopsies from baseline, week 4 (re-biopsy) and surgery for biomarker and biorepository research."	Inflammatory breast cancer defined as clinically significant erythema of the breast and/or documented dermal lymphatic invasion; excisional biopsy of current breast cancer; hormone replacement therapy of any kind, megestrol acetate or raloxifene within one week prior to inclusion; axillary staging surgical procedure prior to study entry; clinical or radiographic evidence of metastatic disease; skin implants in the breast that prevent the required research biopsies or may interfere with palpation of the breast lesion; treatment for cancer, including surgery, radiation therapy, chemotherapy, biotherapy, hormone therapy, or any investigational product prior to study entry; history of previous invasive breast cancer; patient with any other concomitant serious and/or uncontrolled medical condition that may, in the opinion of the Investigator, cause unacceptable safety risks, contraindicate the patient&apos;s participation in the clinical trial or compromise adherence to the protocol (e.g. chronic pancreatitis, chronic active hepatitis, liver cirrhosis or any other significant liver disease, active, untreated or uncontrolled fungal, bacterial or viral infections, active infection requiring systemic antibacterial therapy, etc.) or limit life expectancy to ≤ 5 years.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-8c53fhx	Effects of adopting oral care without the use of antiseptics compared to oral hygiene with chlorhexidine on the occurrence of  pneumonia in patients admitted to an intensive care unit	Recruiting	Intervention	2022-07-18	<NULL>	<NULL>	6785	Effects of adopting oral dental care without the use of antiseptics compared to oral hygiene with chlorhexidine on the occurrence of nosocomial pneumonia in patients admitted to an intensive care unit: a pilot randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8c53fhx	<NULL>	Patients aged 18 years or older admitted to the ICU-HU-UFJF during the study period and without evidence of pulmonary infection at admission will be included	Patients who stayed for less than 5 days in the Intensive Care Unit; patients in whom dental evaluation was not possible; immunosuppressed patients; in palliative care; pregnant women and patients who do not consent or whose closest family member does not consent to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-8dpxgcf	Effects of an exercise program for balance in elderly	Recruiting	Intervention	2022-07-15	<NULL>	<NULL>	5487	Effects of an exercise program on static and dynamic stability in elderly	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2022-02-01	Centro Universitário Augusto Motta	Centro Universitário Augusto Motta	https://ensaiosclinicos.gov.br/rg/RBR-8dpxgcf	<NULL>	Individuals of both genders; Aged 60 years or older; Ability to walk 10 meters, with or without the use of an auxiliary device; Residents of the city of Rio de Janeiro	Individuals who score ≤18 on the Mini Mental State Examination; Individuals with neurological or orthopedic conditions that limit the performance of their activities of daily living; Individuals who have any uncontrolled cardiovascular, pulmonary or metabolic diseases, or any other health condition that may interfere with the safe conduct of the study exercise protocol; Individuals with amputations and/or prostheses in the lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-628bsrm	Effect of regional Anesthetic Technique compared to Nerve Block on Pain for Extraction of primary molars with 2% Lidocaine: A Randomized Clinical Trial	Recruiting	Intervention	2022-07-15	<NULL>	<NULL>	5488	Anesthetic Efficacy of the Vestibular Infiltrative Technique versus Inferior Alveolar Nerve Block on Pain for Extraction of primary mandibular molars with 2% Lidocaine: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-02	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-628bsrm	<NULL>	Children between 6 and 9 years of age, without systemic involvement, ASA I and II, of both sexes, who have a clinical and radiographic indication for extraction of an erupted primary molar and lower molar and who agree to participate in the research. Each child will participate only once in the survey. The following clinical and radiographic inclusion criteria will be analyzed. Clinically: the presence of coronary destruction that makes restoration impossible or the proper use of absolute isolation for endodontic and restorative procedures; the presence of perforation of the pulp chamber floor. Radiographically; deciduous molars with carious lesions or defective restorations associated with signs or symptoms indicative of pulp necrosis, periapical or inter radicular lesion extending over 1/3 of the roots or involving the crypt of the permanent successor tooth; the presence of pathological resorption of more than 1/3 of one or more roots that contraindicate endodontics; the presence of at least one non-resorbed half-length root, previous endodontic failure the persistence of periapical or inter radicular lesion associated or not with clinical signs and symptoms; internal resorption.	Patients with acute pain or presence of odontogenic infection associated with systemic signs and symptoms and cases of urgency; Patients with a history of bleeding or blood clotting problems or who have used medication that alters blood clotting prior to the procedure; Patients with hypersensitivity or a history of allergy to the drugs used in the research; Patients with a history of asthma; Patients with a history of liver disease;Patients with a history of bisulfite allergy; Patients who have reported post-traumatic stress disorder or recurrent hospitalizations, who have a personality or anxiety disorder or a diagnosis of phobia; Patient with neurological disorders or communication difficulties; Patient whose guardian cannot accompany the child and answer the necessary information for the survey within 24 hours following the procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-8c52hn5	Effect of a herbal medicine on body weight and metabolism in postmenopausal women	Recruitment completed	Intervention	2022-07-15	<NULL>	<NULL>	5489	Effect of Dicrostachys glomerata extract on body weight and cardiometabolic markers in postmenopausal women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-13	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8c52hn5	<NULL>	Women; age between 45 and 65 years; in post-menopause; overweight; or obesity	Participants who do not sign the Free Informed Consent form; women who have received hormone therapy in the last 6 months; surgery-induced menopause; with untreated hypothyroidism; presence of kidney or liver diseases; any type of cancer; and with inflammatory or infectious disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-2mw2kwv	Analysis of the benefits of the vibrating platform on the balance of healthy older adults	Recruiting	Intervention	2022-07-15	<NULL>	<NULL>	5490	Investigation of the impact of the vibrating platform on the static balance of healthy older adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2mw2kwv	<NULL>	Elderly people with 60 years or more; without neurological and psychiatric disorders; living in the community.	Patients with cognitive decline; those with movement disorders; subjects with congenital or acquired amaurosis; those with severe cardiovascular and musculoskeletal comorbidities that preclude orthostatism and deambulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-9trnhmk	Tissue healing using a prosthesis made from sterile plastic packaging	Recruiting	Intervention	2022-07-15	<NULL>	<NULL>	5491	Soft tissue reconstruction using polypropylene prosthesis: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-26	Universidade Federal dos Vales do jequitinhonha e Mucuri	Universidade Federal dos Vales do jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-9trnhmk	<NULL>	Age 18 years and over of both sexes; patients admitted to Hospital Nossa Senhora da Saúde due to acute/traumatic injuries regardless of the affected limb;patients belonging to the municipalities that make up the Diamantina Health Macroregion assisted by the Nossa Senhora da Saúde Hospital, Reference in Orthopedics	Patients with chronic injuries; patients with burns;unconscious patients; pregnancy;patients without surgical risk release; use of chronic immunosuppressants or corticosteroids;patients being treated for cancer	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-5yhsrrz	Physiotherapy with biofeedback after knee surgery	Data analysis completed	Intervention	2022-07-14	<NULL>	<NULL>	5484	Knee rehabilitation after meniscectomy: The influence of electromyographic biofeedback in a physiotherapy program	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-22	Escola Superior de Saúde do Alcoitão	Escola Superior de Saúde do Alcoitão	https://ensaiosclinicos.gov.br/rg/RBR-5yhsrrz	<NULL>	Both genders; Age between 18 and 55; underwent arthroscopic partial meniscectomy less than two weeks before beginning physiotherapy	Concomitant anterior cruciate ligament injury; osteoarthritis greater than grade II; previous surgeries in the ipsilateral knee; unconsolidated fractures; partial or total amputation in upper or lower limbs; permanent or temporary dysfunctions of the central or peripheral nerve system	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-5bj464v	In-office bleaching varying the number and time of application	Recruiting	Intervention	2022-07-14	<NULL>	<NULL>	5485	Efficacy and adverse effects of in-office whitening by varying the number and time of application	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-5bj464v	<NULL>	Volunteers of both genders will be included in the study; with a minimum age of 18 years; with good general and oral health; with teeth free of carious lesions; gingival recessions and periodontal disease in the anterior region; who agree with the informed consent (ICF) and one of their canines must be A2 or darker according to the Vita Classical scale (Vita Zahnfabrik, Bad Säckingen, Germany)	Volunteers who have performed a bleaching procedure previously will be excluded from the study; who have reported the presence of previous tooth sensitivity; presence of dental prosthesis; fixed orthodontic appliance; restorations in maxillary anterior teeth; endodontic treatment in maxillary anterior teeth; gingival recessions; teeth with tetracycline staining or fluorosis; visible cracks in the teeth; continuous use of medications such as analgesics and anti-inflammatories; pregnant or lactating women and those with habits such as bruxism or smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-3wkcvyw	Physical Exercise decreasing appetite	Recruitment completed	Intervention	2022-07-14	<NULL>	<NULL>	5486	Exercise-Mediated appetite suppression	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3wkcvyw	<NULL>	Male and with no experience with resistance training (never trained or been 6 months or more without weight training); Being eutrophic (BMI between 18.5 and 24.9 kg/m2) or overweight (BMI higher 25.0 and 29.9 kg/m2) according to the World Health Organization (WHO, 1995); Do not present musculoskeletal impairments that compromise the assessments or tests; Not present metabolic alterations (diabetes, hypertension or continuous use of any type of medication); Do not use or have used in recent years any type of steroids or illegal agents that may compromise performance; Non-smokers and with stable weight in the last six months; Present a medical certificate that he is able to carry out all the evaluations and training program	To have an eating disorder or disliking some of the food that will be provided; Presence of planned surgeries during the study period; Reluctance to sign an informed consent form; Participation in another study, Alcohol or drug abuse; and Absence from any evaluation or scheduled test routine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:09
RBR-9k8ymkm	Effectiveness of in-office dental bleaching using 35% hydrogen peroxide with different application tips	Recruiting	Intervention	2022-07-13	<NULL>	<NULL>	5482	Effectiveness of in-office dental bleaching using 35% hydrogen peroxide with different application tips: randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-04	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9k8ymkm	<NULL>	Minimum 18 years of age; in good general and oral health; teeth free of carious lesions; without gingival recession and periodontal disease in the anterior region; who agree with the Free and Informed Consent Form (TCLE) and one of their canines should be A2 or darker in color according to the Vita Classical scale	Whitening procedure previously; previous dental sensitivity; dental prosthesis; fixed orthodontic appliance; restorations in the anterior superior teeth; endodontic treatment on anterosuperior teeth; gingival recessions; teeth stained by tetracycline or fluorosis; visible cracks in the teeth; continuous use of medications; pregnant or lactating women; bruxism; smokers	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-37xt8f6	Effect of co-contraction training on muscle mass, torque and functional capacities in older people	Not yet recruiting	Intervention	2022-07-13	<NULL>	<NULL>	5483	Effect of a coactivation training program, on functional capacity and gait biomechanical parameters, in older people	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Marina Mello Villalba	Universidade de São Paulo - Escola de Educação Física e Esporte de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-37xt8f6	<NULL>	Healthy older; active or non active; aged between 60 to 80 years; available to participate in this research for eight weeks; non participant in any other physical exercise program during this period; all participants must sign an informed consent form.	Walking with an assistive device (cane, crutches, walker); presence of neurological disease; orthopedic impairment in the last 6 months in lower limbs (sprains, ligament ruptures, muscle injuries, fractures and surgeries); backache; vestibular impairment (presence of vertigo or labyrinthitis); non-corrective visual impairment by lenses; low score on the cognitive test.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-9dtbj6w	Treatment with LED and Exercises to Reduce Venous Wounds on Legs	Recruiting	Intervention	2022-07-12	<NULL>	<NULL>	5479	LED and Exercises to reduce the area of Venous Ulcers: controlled and randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-31	Centro de Ciências da Saúde	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9dtbj6w	<NULL>	Being over 18 years of age; having chronic venous insufficiency and active varicose ulcer diagnosed by an angiologist; present leg ulcers with a size of at least 1cm2; have cognitive and physical integrity to perform exercises; not having associated arterial disease; not having active/recent deep vein thrombosis (less than 6 months); not having photosensitive diseases and neuropathies of the lower limbs; not using corticosteroids; having a medical certificate authorizing him/her to perform the proposed physical activities.	Express request not to participate in the study after inclusion; impossibility of carrying out the reassessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-2fkzb2s	Effect of acupuncture with electrical stimuli and therapy with games in elderly with knee arthrosis	Data analysis completed	Intervention	2022-07-12	<NULL>	<NULL>	5481	Effect of Electroacupuncture and Wii therapy on functional performance and inflammatory parameters in elderly with knee osteoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-08-08	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-2fkzb2s	<NULL>	Be 60 years of age or older;Have a diagnosis of osteoarthritis in at least one knee, based on the American College of Rheumatology clinical and radiographic criteria (Hinton, et al. 2002); with classification II, III or IV in the classification grades of Kelgreen and Lawrence (Kelgreen &amp; Lawrence, 1657);Have symptoms for knee osteoarthritis with scores equal to or greater than two on the visual analogue pain scale (VAS);Not having undergone any surgical procedure on the lower limbs;Not having had recent trauma to the knees;Not having undergone physical therapy treatment or any other rehabilitation procedure in the last three months;Present minimal clinical and cognitive conditions to perform physical activities;Not using glucocorticoids for at least two months.	Elderly people with knee or hip arthroplasty; Acute orthopedic, neurological, respiratory or cardiac diseases that prevent them from performing the proposed exercise; Cognitive deficit suggested by a lower score than those compatible with their education when performing the Mini Mental State Examination (for illiterate people the score is 13; for schooling between one to three years, 18; for schooling between four to seven years, 23; for schooling over seven years, 26) (BERTOLUCCI et al., 1994); Vestibular disorders; Immunosuppressed or immunodeficient .	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-10b33dwf	Action of oral hydrating gel with menthol in small particles on thirst: a controlled clinical study	Recruitment completed	Intervention	2022-07-11	<NULL>	<NULL>	5477	Action on hydrating gel with microencapsulated menthol on thirst: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-10b33dwf	<NULL>	Be aged between 18 and 50 years old be of both sexes. Be fasting for 8 hours of solids and liquids	Being allergic to menthol Being allergic to one of the components of the product Present nausea or vomiting during the approach Present salivary dysfunctions Present lesions or dysfunctions in the oral cavity Having the flu or having a respiratory condition being a smoker or having chronic diseases such as hypertension and diabetes Present salivary dysfunctions present lesions in the oral cavity brush your teeth at least 2 hours before collection smoker drink alcoholic beverages for 24 hours perform physical exercises for 60 minutes before collection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-5h255qr	Response to Different Doses of Vitamin D Supplementation in Individuals with Obesity: A Randomized Clinical Trial	Recruiting	Intervention	2022-07-11	<NULL>	<NULL>	5478	Vitamin D deficiency in individuals with obesity, with and without diabetes: association with genetic and non-genetic factors and response to different forms of supplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-24	Hospital de Clínicas de Porto Alegre	Núcleo de Pesquisa Clínica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5h255qr	<NULL>	White individuals; obesity (body mass index greater than or equal to 30 Kg/m²); 25-hydroxyvitamin D levels less than 20 ng/mL.	Medications that may affect vitamin D levels; kidney disease; liver disease; bone disorders; absorptive disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-52y3zgd	Effects of Transcranial Stimulation and balance training in individuals with Parkinson: a randomized clinical trial	Recruitment completed	Intervention	2022-07-11	<NULL>	<NULL>	6300	Effects of Transcranial Direct Current Stimulation (tDCS) associated with balance training in individuals with Parkinson&apos;s disease: randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal do Amazonas	Hospital Universitário Getúlio Vargas	https://ensaiosclinicos.gov.br/rg/RBR-52y3zgd	<NULL>	Individuals of both sexes, regardless of age, with a clinical diagnosis of PD, rated 3 or 4 on the Hoehn &amp; Yahr scale, and who agreed to participate in the study by giving consent, were included.	Individuals with other neurological disorders other than PD and with cognitive deficits that prevented them from performing the assessments were not included, and individuals with scores lower than 8 on the 10 Point Cognitive Screener (10-CS) were not included. Individuals who were undergoing Physiotherapeutic care, who had undergone Physiotherapy for less than 1 month, or who had a Deep Brain Stimulation device (DBS) were also not included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:38
RBR-4jq79xt	The treatment of a malocclusion related to lack of dental contact between the upper and lower teeth with a fixed appliance: a randomized clinical trial	Not yet recruiting	Intervention	2022-07-10	<NULL>	<NULL>	5476	Anterior Open Bite Treatment with Fixed Tongue Educator: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-10	Universidade Federal do Pará	Centro Universitário do Pará	https://ensaiosclinicos.gov.br/rg/RBR-4jq79xt	<NULL>	patients in mixed dentition; anterior open bite greater than or equal to 1 mm	Patients with cognitive difficulties; cleft lip and palate; syndromes and; or anomalies and dental agenesis will be previously excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-7kqqqxn	Evaluations in intellectual disabled in the pre-sport program of Hippotherapy	Data analysis completed	Intervention	2022-07-08	<NULL>	<NULL>	5472	Impact of the pre-sporting program for hipppotherapy on posture, strength, balance and electrical activity in individuals with intellectual disabilities	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-29	Universidade Federal do Triângulo Mineiro	Associação de Pais e Amigos dos Excepcionais de Uberaba - APAE	https://ensaiosclinicos.gov.br/rg/RBR-7kqqqxn	<NULL>	Individuals with fifteen years old and maximum twenty years old; both genders; be regularly enrolled at APAE/Uberaba-MG; ability to understand verbal commands and medical diagnosis of intellectual disability; informed Consent Form signed by parents and/or guardians	uncontrolled seizures; spinal instability; herniated disc; shoulder and/or hip dislocations; scoliosis above 30 degrees; acute rheumatic processes; acute heart disease; hydrocephalus with valve or associated syndromes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-539w5nw	Balance Training through Virtual Rehabilitation in patients who have suffered a Stroke	Recruitment completed	Intervention	2022-07-08	<NULL>	<NULL>	5473	Balance Training in hemiparetic patients through Virtual Rehabilitation	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2012-04-20	Centro Universitário Central Paulista	Centro Universitário Central Paulista	https://ensaiosclinicos.gov.br/rg/RBR-539w5nw	<NULL>	Volunteers who suffered ischemic stroke; of both genders; age between 30 and 60 years; sequelae of hemiparesis for at least 6 months	Volunteers who had other illnesses not related to the stroke; those who were in the acute or subacute phase of the disease; those who suffered a hemorrhagic stroke; hemiplegics; amputees; wheelchair users or orthotics; visually and/or hearing impaired; those who could not understand or respond to data collection instruments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-5hz9g6z	Evaluation of Familias Fortes Program&apos;s Effectiveness (Strengthening Families Program SFP 10-14)	Recruitment completed	Intervention	2022-07-08	<NULL>	<NULL>	5474	Evaluation of Familias Fortes Program &apos;s the Effectiveness and Implementation Process on preventing drug use and strengthening family relationships (Strengthening Families Program - SFP 10-14)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-04	Universidade Federal de São Paulo - UNIFESP	Ministério da Mulher, da Família e dos Direitos Humanos	https://ensaiosclinicos.gov.br/rg/RBR-5hz9g6z	<NULL>	Families with at least one child or adolescent between 12 and 14 years old assisted by the CRAS (Social Assistance Reference Center) or similar service; at least one of the parents or guardians and a child or adolescent from the same family willing to participate in the program; availability to attend 7 meetings in 7 consecutive weeks, on the same day of the week, pre-defined; live within 1 kilometer of the CRAS (Social Assistance Reference Center).	"Families who do not live together, for example, the child is in the care of others; families with high needs (such as drug addiction, family breakdown and serious behavior problems that could interfere with the group&apos;s progress); families who are involved in a program that has the same objective or that 
 participated in the Famílias Fortes program at another time."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-2v2k9gg	Neurostimulation of the motor area and its effects on anxiety, depression and inflammation in patients with rheumatoid arthritis	Not yet recruiting	Intervention	2022-07-08	<NULL>	<NULL>	5475	Transcranial Direct Current Stimulation (tDCS) on the motor cortex: effect on anxiety and depression symptoms and the interplay with the inflammatory profile of pacients suffering from chronic pain since diagnosed with rheumatoid arthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-15	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-2v2k9gg	<NULL>	Patients with chronic pain manifested for a minimum period of 12 weeks; in clinical treatment with synthetic DMARDs; who present pain in intensity greater or equal 7 by the visual analogical pain scale (EVA-Dor); Who present anxiety symptoms according to the Beck scale (psychological assessment instrument, BAI, Beck Anxiety Inventory); who present symptoms of depression according to the Beck psychological assessment instrument, BDI, Beck Depression Inventory	Patients who have other autoimmune diseases not related to AR; Who are being treated with biological DMARDs; pregnant women; who have a clinical diagnosis of major depressive disorder (greater than 30 in the evaluation score according to Beck Depression Inventory, BDI); with clinical diagnosis of generalized anxiety disorder (GAD), (greater than 31 in the evaluation score according to Beck Anxiety Inventory, BAI); patients with a history of skin diseases; who use high doses of opioids; with a history of illicit drug use/abuse; with metal implants in the cranial or facial region; that use pacemakers; with a history of seizures or epilepsy; with neurological, cognitive and motor deficits; patients who underwent craniotomy; patients with cancer diagnosis; decompensated disease (ischemic heart disease, kidney and/or liver diseases)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-2wbrh3t	Multicenter Clinical Trial  for the Treatment of Dry Eye and Meibomian Gland Dysfunction whit iLUX	Data analysis completed	Intervention	2022-07-08	<NULL>	<NULL>	8125	Evaluate the effect of heat application by light emission and compression under direct observation with the iLUX device for the treatment of Dry Eye and Meibomian Gland Dysfunction	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-02-01	Clínica Oftalmológica Pereira Gomes	Clínica Oftalmológica de Antioquia	https://ensaiosclinicos.gov.br/rg/RBR-2wbrh3t	<NULL>	Age over 18 years; Patients who signed the consent form; Availability to attend all study visits; Positive history of dry eye symptoms prior to the study, using ocular surface disease index  greater than or equal to 13 at patient&apos;s first visit; Evidence of Meibomian gland disfunction, diagnosed by a clinician not involved in the study and defined as a Meibomian gland secretion score less than 12 in 15 glands assessed in the lower eyelid; Non-invasive tear film break-up time (NIBUT) less than 10 seconds using the Keratograph 5M; Consent/ability to abstain from other dry eye/Meibomiun gland disfunction medications during the time between the screening visit and the end of the study;	Ocular surgery in the last 6 months; Cicatricial lid margin disease (symblepharon) identified by slit-lamp examination; Active ocular infection or active ocular inflammation or history of chronic, recurrent ocular inflammation within the prior 3 months; Treatment with LIpiFlow or Intense Pulsed Light Therapy in the previous 12 months; Treatment with omega-3; Use of topical cyclosporine; Use of topical steroids	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:45
RBR-2sypq9j	Impact of daily energy shortage announcements on ICU calorie supply: a pragmatic trial	Data analysis completed	Intervention	2022-07-07	<NULL>	<NULL>	5471	Impact of daily enunciation of energy deficit on ICU heat supply: a pragmatic trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-23	Hospital Geral de Fortaleza	Hospital Geral de Fortaleza	https://ensaiosclinicos.gov.br/rg/RBR-2sypq9j	<NULL>	Adults and seniors, aged 18 years or over; both sexes; being on mechanical ventilation or being intubated within 48 hours of admission; being receiving or starting to receive enteral nutritional therapy within 48 hours of admission; present a diagnosis that possibly requires enteral nutritional therapy for more than 7 days	Subjected to supplemental or total parenteral nutritional therapy in the initial 7 days; submitted to major digestive surgeries; history of short bowel syndrome, inflammatory bowel disease, previous recurrent record of diarrhea; admitted with major digestive bleeds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-2gj78z9	Comparative clinical study between treatment with papain gel 2% and 10% in patients with lower limb ulcers.	Data analysis completed	Intervention	2022-07-06	<NULL>	<NULL>	5467	Randomized double blind clinical trial, comparing treatment with papain gel 2% and 10% in patients with lower limb ulcers.	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-08-29	Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro	Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-2gj78z9	<NULL>	Patients with lower limb ulcers; aged 18 or over; male or female; who agreed to participate voluntarily in the research	Patients under 18 years old; with ulcers with malignant transformation (cancer); arterial disease; osteomyelitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-5hk3q96	The influence of instrumental lymphatic drainage on gestational edema	Terminated	Intervention	2022-07-06	<NULL>	<NULL>	5468	The influence of the dermotonia technique on gestational edema	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Luana Rocha Paulo	Universidade do Estado de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5hk3q96	<NULL>	Low pregnancy riscs, being between the 2nd and 3rd trimester of pregnancy and complaining of edema in the lower limbs (LL), heaviness, tiredness in the legs or suffering in the body.	Twin pregnancy, with the presence of specific hypertensive disorders of pregnancy (DHEG), presence of bleeding, dermatoses, unwanted contractions, flu-like symptoms and any other medical restriction to participate in the study. Volunteers who were already undergoing some specific treatment to control edema, such as manual lymphatic drainage, were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-5f426rx	Effects of using Colchicine for the prevention of inflammatory complications, arrhythmias and pain control in the postoperative period of cardiac surgery.	Data analysis completed	Intervention	2022-07-06	<NULL>	<NULL>	5470	Effects of Colchicine in the prevention of Post-pericardiotomy syndrome, pain control and occurrence of Atrial Fibrillation in the postoperative period of Cardiac Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Universidade de Santa Cruz do Sul	Universidade de Santa Cruz do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5f426rx	<NULL>	Patients in post operative of cardiac surgery; both sexes; age 18 to 85 years.	Patients undergoing emergency cardiac surgery; presence of atrial fibrillation in the preoperative period; use of pacemakers; patients with chronic renal failure; patients undergoing treatment for endocarditis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-67wbv3r	Effects of physical exercise associated with laser therapy on functional capacity and muscle performance in individuals with persistent symptoms of Covid-19	Not yet recruiting	Intervention	2022-07-06	<NULL>	<NULL>	5598	Effects of physical exercise associated with photobiomodulation therapy on functional capacity and muscle performance in individuals with persistent symptoms of Covid-19	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Federal de Santa Catarina - Campus Araranguá	Laboratório de Avaliação e Reabilitação do Aparelho Locomotor-LARAL (UFSC/Campus Araranguá)	https://ensaiosclinicos.gov.br/rg/RBR-67wbv3r	<NULL>	Individuals aged between 18 and 70 years, of both genders with musculoskeletal pain, myalgia or arthralgia, persisting after four weeks of Covid-19 infection. Individuals with pain rating equal to or greater than 3 on the Visual Analogue Scale. Individuals classified as grade 1, 2 and 3 on the modified Medical Research Council scale	Individuals with pain rating lower than 3 on the Visual Analogue Scale. Individuals with grades 4 and 5 on the modified Medical Research Council scale. Individuals with chronic pain complaint in the treatment region, prior to Covid-19. Individuals with epilepsy, fibromyalgia, cardiac alterations and decompensated diabetes. Recent surgeries in regions related to the treatment site with less than 3 months; Laser photosensitivity; Continuous use of analgesics, muscle relaxants or anti-inflammatory drugs in the 48 hours prior to the intervention. pregnant women. Individuals with neurological and cognitive dysfunctions, such as dementia, intellectual disability, communicative deficit or any other condition that makes it impossible to understand the study procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-48kjwtj	Effects of food and nutrition education activities on food consumption, nutritional status and cardiovascular health in family members of overweight children	Recruiting	Intervention	2022-07-05	<NULL>	<NULL>	5465	Effects of a food and nutritional education program on food consumption, nutritionaal status and cardiometabolic parameters in family members of overweight and obesity  children  in the municipality of Vitória de Santo Antão	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-48kjwtj	<NULL>	Family members or adult family members, aged 20 and less than 60 years; Living in the same household as children aged 7 to 10 years that are enrolled in the municipal education network of Vitória de Santo Antão.	Family members who do not live in the same household as the child; Family members who have pathologies that may affect their nutritional status and/or food consumption, such as cancer; acquired immunodeficiency syndrome; liver diseases; Pregnant women; family members who do not adhere to the food and nutrition education program or who give up during the course of the proposed intervention;  Participants who are absent in more than twenty five percent of the meetings, that is, in more than 2 meetings	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-9sh54h5	Ultrasound-guided thoracoabdominal nerve block in patients undergoing Stomach Reduction Surgery	Recruiting	Intervention	2022-07-05	<NULL>	<NULL>	5466	Modified thoracoabdominal nerve block by perichondral approach (M-TAPA) guided by Ultrasonography in patients undergoing Laparoscopic Sleeve Gastroplasty: a prospective study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Plinio da Cunha Leal	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9sh54h5	<NULL>	Age between 18 and 65 years; both sexes; American Society of Anesthesiologists (ASA) physical status I, II, or III; patients undergoing Sleeve type bariatric surgery	Severe comorbidity with American Society of Anesthesiologists (ASA) physical status IV; cardiac arrhythmias; dilated cardiomyopathy; cardiac conduction disturbance; electrolyte disturbance; acid-base disturbance; hypersensitivity to lidocaine; psychiatric, hepatic, respiratory or oncological diseases, who are receiving any type of analgesic in the week before surgery; patients receiving hemoderivatives during the study period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-9szgmpp	Deep Heat Application in Women with Fibromyalgia	Not yet recruiting	Intervention	2022-07-04	<NULL>	<NULL>	5461	The effects of Radiofrequency in patients with Fibromyalgia: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-30	Instituto de Neurologia, Neurocirurgia e Comportamento	Universidade Federal do Amazonas - Instituto de Saúde e Biotecnologia	https://ensaiosclinicos.gov.br/rg/RBR-9szgmpp	<NULL>	Women; over 18 years of age; with fibromyalgia; one year of diagnosis; accepted to participate in the intervention	Women with metallic implants at the application site; with sensitivity alterations at the application site; with silicone prostheses; with a cardiac pacemaker; with neoplasms; with acute inflammatory processes; who are pregnant; with ischemic tissues; with tuberculous lesions; who have had recent deep vein thrombosis; with hemorrhagic conditions or the likelihood of this occurring; with heart disease; with decompensated blood pressure; who have attendance lower than 75% at the appointments/treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-738zkp7	Effects of cerebral stimulation during treadmill training on gait in people with Parkinson&apos;s disease	Not yet recruiting	Intervention	2022-07-04	<NULL>	<NULL>	5462	Effects of transcranial direct current stimulation combined with treadmill training on gait in people with Parkinson&apos;s disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Universidade Estadual Paulista, Instituto de Biociências, campus de Rio Claro	Universidade Estadual Paulista, Instituto de Biociências, campus de Rio Claro	https://ensaiosclinicos.gov.br/rg/RBR-738zkp7	<NULL>	Subjects with diagnosis of idiopathic Parkinson&apos;s disease given by a private neurologist, according to the London Brain Bank criteria.	Subjects with another neurological disease in addition to Parkinson&apos;s disease; subjects in stage above of 3 on the adapted Hoehn &amp; Yahr scale; subjects with characteristics that make transcranial direct current stimulation risky (neural implants, history of seizures, pacemaker, epilepsy); history of orthopedic and/or vision problems that make it impossible to comply with experimental procedures; indicative of dementia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-8dtxtcm	Home-based exercise for college students during the COVID - 19 pandemic	Recruitment completed	Intervention	2022-07-04	<NULL>	<NULL>	5463	Effects of a home-based exercise program on mental health for college students during the COVID-19 pandemic: a controlled trial	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-03	Profa. Dra. Iane de Paiva Novais	Universidade Estadual do Sudoeste da Bahia - UESB	https://ensaiosclinicos.gov.br/rg/RBR-8dtxtcm	<NULL>	Female students; age from 18 years; enrolled in undergraduate or graduate courses offered by the State University of Southwest Bahia, on the Jequié, Vitória da Conquista or Itapetinga campuses; no restrictions for the practice of physical activity; with availability to participate in the activities proposed by the researchers; agreement and signature of the Free and Informed Consent Form	Not answering the questionnaires in full; answer one or more questions in the Physical Activity Readiness Questionnaire in the affirmative; and or present any physical or mental condition that prevents the performance of exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-10k4gqdg	Replacement of Vitamin D in Women with Breast Cancer Who Will Undergo Chemotherapy Before Surgery	Recruiting	Intervention	2022-07-04	<NULL>	<NULL>	5464	Vitamin D Supplementation in Women with Breast Cancer Undergoing Neoadjuvant Chemotherapy: Randomized, Double-Blind, Placebo-Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-22	Universidade Estadual Paulista - Unesp	Universidade Estadual Paulista - Unesp	https://ensaiosclinicos.gov.br/rg/RBR-10k4gqdg	<NULL>	Women aged above 45 years with a recent histological diagnosis of breast cancer, eligible for neoadjuvant chemotherapy (presence of luminal tumors A or B with clinically positive armpit; luminal tumor B larger than three centimeters; triple negative tumor; tumor Human Epidermal growth factor Receptor-type 2 positive, pure or hybrid, stage III)	Vitamina d supplementation women with breast carcinoma in situ, previous history of other cancers, chronic kidney disease (creatinine upper 1.4 milligrams/deciliter), liver disease, alcohol or drug addiction will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:08
RBR-3mtt9vz	Use of non-invasive electric stimulation in stuttering treatment	Terminated	Intervention	2022-07-01	<NULL>	<NULL>	5460	Bi-hemispheric tDCS as an adjuvant in the treatment of people who stutter: a randomized, double-blind preliminary trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-01	Laboratório de Neurociência e Comportamento da Universidade de Brasília	Laboratório de Neurociência e Comportamento da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-3mtt9vz	<NULL>	Native speakers of Brazilian Portuguese speaker; age between 18 to 55 years old; diagnosis of stuttering	Presence of speech disorders other than stuttering; Presence of non-corrected visual perceptual deficits; Presence of any auditory perceptual deficits; Presence of any reported neurological or psychiatric comorbidities; Use of medication with action upon the central nervous system; Presence of any contraindications to transcranial direct current stimulation (tDCS) usage, such as seizures, in the medical history, intracranial metallic implants	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5fqffpc	Determination of the glycemic index and glycemic load of an ice cream with polydextrose	Other	Intervention	2022-06-30	<NULL>	<NULL>	5457	Determination of the glycemic index and glycemic load of an ice cream rich in polydextrose. A randomized clinical trial	<NULL>	1, randomized-controlled, open	1	<NULL>	<NULL>	<NULL>	2021-08-18	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5fqffpc	<NULL>	Volunteers with absence of metabolic disorders, such as diabetes mellitus; absence of cardiovascular, liver or kidney diseases; cancer; thyroid disorders; absence alcoholism; absence of morbid obesity	Children; pregnant women; elderly, individuals with allergies and/or intolerance to any component of the formulations;  who do not provide authorization by signing the Informed Consent Term; who did take medications in the past three months that affect glycemic metabolism	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-107dyj7w	The use or not of needles to anesthetize patients with pulpal inflammation	Recruiting	Intervention	2022-06-30	<NULL>	<NULL>	5458	Use of oral anesthesia with and without the aid of needles in patients with inflammation in the dental pulp: a Randomized Clinical Study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-08	Universidade CEUMA (Centro Universitário do Maranhão)	Universidade CEUMA (Centro Universitário do Maranhão)	https://ensaiosclinicos.gov.br/rg/RBR-107dyj7w	<NULL>	To be eligible for this study, patients must have the following characteristics: Patient who volunteered to participate in the study, aged between 18 and 50 years; Presence of permanent maxillary molars and premolars with diagnosis of symptomatic irreversible pulpitis (Patient with history of nocturnal pain or spontaneous pain and cold pulp sensitivity test with positive response and slow decline); Systemically healthy patient	The following will be excluded from the research: lower teeth; teeth that present trauma; teeth with periodontal alterations (pocket with more than 3 mm, mobility and gingival edema); teeth with pain on apical palpation and teeth with pulp necrosis; patients who are allergic to sulfonamides; patients with uncontrolled diabetes; patients with uncontrolled hypertension; patients with myocardial infarction aged less than 6 months; pregnant women due to the risk of methemoglobinemia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-9yrp6nh	Telerrehabilitation as exercise option in patients undergoing surgery for breast cancer treatment	Recruitment completed	Intervention	2022-06-30	<NULL>	<NULL>	5459	Telerehabilitation as a therapeutic option in patients undergoing surgery for breast cancer treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-9yrp6nh	<NULL>	women aged 20or over, diagnosed with breast cancer, who have undergone or who will still undergo surgery, radiotherapy and/or chemotherapy	myoskeletal dysfunction prior to breast cancer, or any other orthopedic or neurological disorder that may alter the results of the present study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-6t74w6g	Bisphenol-A release in orthodontic materials used to treat anterior open bite.	Recruitment completed	Intervention	2022-06-29	<NULL>	<NULL>	5454	Bisphenol-A release and biocompatibility of orthodontic adhesive system used for spur bonding in patients with anterior open bite: In vivo study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2018-08-10	Faculdade de Odontologia da Universidade Federal de Minas Gerais	Faculdade de Odontologia da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-6t74w6g	<NULL>	Subjects will be included in the study: Systemically healthy; with good oral hygiene; with presence of anterior open bite; Normal periodontal: The periodontal parameters adopted to assess the normal state will be those established by Lindhe, Lang and Karring (2014) and Carranza and Sznajder (1996). These parameters are Probing Depth, Visible Plaque Index, Gingival Index, and Probing Bleeding Index .	Subjects will be excluded from the study: With severe systemic alteration; on antibiotics and anti-inflammatory drugs in the last three months; with abnormal periodontium; patients with clinical signs of parafunctional habits; who have performed restorations in the last 12 months; periodontal sites that showed bleeding during crevicular fluid collection or sites that prevent adequate collection of clinical parameters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-54j3726	Clozapine for Autism Spectrum Disorder patients aged 10 to 18 years with severe behavioral problems that have not responded to previous medications.	Recruiting	Intervention	2022-06-29	<NULL>	<NULL>	5455	Clozapine for the treatment of refractory disruptive behaviors in 10-18 years old patients with Autism Spectrum Disorder: an open-label trial	<NULL>	4, n/a, open	4	<NULL>	<NULL>	<NULL>	2022-04-01	Hospital de Clínicas de Porto Alegre	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-54j3726	<NULL>	Diagnosis of Autism Spectrum Disorder; boys and girls aged 10 to 18 years; disruptive behaviors with two failures of antipsychotic treatment; Moderate or greater behavioral problems as measured by a Clinical Global Impression Scale—Severity (CGI-S) score of 4 or higher at screening; involvement of a parent or caregiver able to consistently complete assessments throughout the study.	Clinical disease that contraindicates the use of clozapine; history of serious side effects to clozapine; previous treatment failure to the use of clozapine; pregnancy or breastfeeding; absence of psychosocial support considered enough to follow the study protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5vnnqnk	Management of Overweight	Recruiting	Intervention	2022-06-29	<NULL>	<NULL>	5456	Strategy for the management of Overweight in primary health care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-19	Universidade Estadual do Ceará	Universidade Estadual do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-5vnnqnk	<NULL>	Women; eighteen to forty-five years; to be in the sixth month postpartum; have a body mass index greater than or equal to twenty-five kilograms per square meter	Pregnant women; Present a diagnosis of a pre-existing chronic disease during pregnancy (diabetes, hypertension and cancer); being monitored by a nutritionist	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-102mkz52	Effects of different training volumes in the elderly on muscular and cardiovascular function	Recruitment completed	Intervention	2022-06-28	<NULL>	<NULL>	5449	Different training volumes in the elderly: effects on muscle function and cardiovascular	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-14	Universidade Federal do Estado de São Paulo	Universidade Federal do Estado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-102mkz52	<NULL>	Men and Women aged over 60 years; no psychiatric or neurological disorder; be able to practice physical activity, proven by a medical certificate; that present physical conditions that allow the execution of the tests; sedentary for at least 6 months	have any disease that does not allow the practice of regular physical activity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5424gfp	Creatine Supplementation Safety for Older Woman	Terminated	Intervention	2022-06-28	<NULL>	<NULL>	5450	Creatine Supplementation Safety for Olders	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-05	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-5424gfp	<NULL>	Be physically active for at least 6 months. Do not use psychoactive medications.	Having suffered an injury or fall in the last 2 months; cognitive difficult; advanced-stage neurodegenerative diseases; Have sequelae of a stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-6fsprpc	Effect of bicarbonate anesthesia on mandibular molars	Recruitment completed	Intervention	2022-06-28	<NULL>	<NULL>	5451	Anesthetic effect of 4% and 2% alkalized Articaine for infiltrative anesthesia in mandibular molars	<NULL>	1, randomized-controlled, triple-blind	1	<NULL>	<NULL>	<NULL>	2021-08-01	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	Faculdade de Odontologia de Piracicaba- Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-6fsprpc	<NULL>	Healthy individuals; Age 18 years or older; Previous experience of local anesthesia (have already taken it on another occasion); No history of complications resulting from local anesthesia; Lower molars on both sides healthy (absence of restorations); Responsible for the electrical stimulus “Pulp Tester”.	Pregnant women; lactating women; with systemic involvement that would contraindicate anesthesia; History of allergic reaction to any component of the anesthetic solutions used; Presence of an inflammatory condition in the region.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-4kfh2bk	Evaluation of the influence of the therapeutic hot tub on diaphragmatic mobility in newborns	Recruiting	Intervention	2022-06-28	<NULL>	<NULL>	5452	Physiotherapy in newborn hospitalized in the neonatal icu	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-10	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4kfh2bk	<NULL>	Participants of both sexes will be selected; RNT (term newborn) and PTNB (preterm newborn); weighing around 1.250g; from the 1st week of life; clinically stable; with full enteral nutrition (breast, nasogastric tube or cup); in the process of daily weight gain; with oxygen therapy or in room air	Newborns with hemodynamic instability; hyperthermia (above 37,8 °C) and hypothermia (below 36,4 °C); invasive devices (central and peripheral venous access, umbilical catheter, gastrostomy, plastic or metallic tracheostomy); presence of remaining umbilical cord; skin lesion; infectious diseases; decompensated cardiovascular diseases; history of uncontrolled seizures; presence of orthopedic immobilization; failure to sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-289hz3v	Effect of Brazil nut consumption as a source of selenium on the production of free radicals, inflammation and its relationship with a genetic polymorphism of glutathione peroxidase 1 in women with rheumatoid arthritis.	Data analysis completed	Intervention	2022-06-28	<NULL>	<NULL>	5453	Effect of Brazil nut supplementation (Bertholletia excelsa H.B.K.) as a source of selenium on oxidative stress markers, inflammatory cytokines, and their relationship with Pro198Leu polymorphism in the glutathione peroxidase 1 gene in patients with rheumatoid arthritis.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2011-03-07	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	Faculdade de Ciências Farmacêuticas da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-289hz3v	<NULL>	Patients diagnosed with rheumatoid arthritis (criteria established by the American College of Rheumatology); pharmacological stability of at least 3 months; Healthy individuals with no diagnosis of rheumatologic and autoimmune diseases.	Not pregnant; not be in lactating period; not participating in another clinical trial; not using vitamin-mineral supplements (except calcium and vitamin D); not smoking; not abusing alcohol; not have diagnostic of cancer, thyroid, kidney diseases; not consuming Brazil nuts regularly.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-10rv3fqt	Suspension training and chronic low back	Not yet recruiting	Intervention	2022-06-27	<NULL>	<NULL>	5447	Comparison of the effects of two suspension training protocols on pain and skeletal muscle function of individuals with  chronic low back pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10rv3fqt	<NULL>	chronic nonspecific, persistent or periodic low back pain for more than three months; 18 and 60 years of age;  pain with a Numerical Pain Scale greater than 3 on the day of assessment; be classified as at least moderately active according to the Human Activity Profile Questionnaire.	"pregnant women; lactating women; sedentary individuals; Body Mass Index (BMI) greater than or equal to 30 kg/m2; without physical therapy treatment simultaneously with the study period; surgery in the lumbar region; without clinical diagnosis of low back pain; not present low back pain radiating to the glutes and lower limbs; sensory alteration in the lower limbs and the use of medication to relieve low back pain 48 hours before the performance of the exercises;  neurological disease, previous 
diagnosis of heart disease, acute lung disease, pregnant women, uncontrolled hypertension beginning of medication use less than 1 year ago), orthopedic injuries."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-88x77qj	The immediate influence of chiropractic joint manipulation on the upper cervical spine and its relationship with the free throw performance in basketball	Recruitment completed	Intervention	2022-06-24	<NULL>	<NULL>	5443	The immediate influence of chiropractic joint manipulation on the upper cervical spine and its relationship with the free throw performance in basketball	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-10	Universidade Anhembi Morumbi	Universidade Anhembi Morumbi	https://ensaiosclinicos.gov.br/rg/RBR-88x77qj	<NULL>	Selection criteria were age between 14 and 20 years; basketball practice for at least 1 year; and regular attendance at club practices and competitions.	Exclusion criteria were reporting signs of contraindication for chiropractic manipulation on upper cervical spine; spinal abnormalities, such as signs of progressive neurological deficit; signs of meningeal irritations; and signs of joint instability; as well as histories of fractures, injuries, and/or infections in the upper limb and spine; cancer; hypertension; osteoporosis; thrombosis; and a history of stroke.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5cr6ngd	Laser Ear Acupuncture to treat jaw joint changes	Not yet recruiting	Intervention	2022-06-24	<NULL>	<NULL>	5444	The effect of Laser Auriculotherapy for the treatment of Temporomandibular Dysfunction: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-20	Sara Lisboa Marques	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5cr6ngd	<NULL>	"Presence of temporomandibular disorder confirmed by the Diagnostic Criteria for Temporomandibular
Disorders DCTMD; age group from 18 to 50 years; availability to attend the research site during the study period"	Use of piercing or birthmark; history of neoplasia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5hjbmtx	Relationship between IOP reduction and ocular blood perfusion	Recruitment completed	Intervention	2022-06-24	<NULL>	<NULL>	5445	Effect of IOP reduction on peripapillary vascular density in eyes with optic disc drusen	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2021-08-01	Hospital Oftalmológico de Brasília	Hospital Oftalmológico de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-5hjbmtx	<NULL>	Patients with optic disc drusen without a history of treatment with hypotensive eye drops; patients older than 18 years; absence of macular diseases; absence of vascular optic diseases; axial diameter less than 25mm; open camerular angle on gonioscopic examination	Patients with optic disc drusen who have already used hypotensive eye drops; patients under 18 years of age; presence of any maculopathy or vascular optic disease; axial diameter greater than 25mm; closed camerular angle on gonioscopic examination	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-102nsx22	The effect of rosemary use in decreasing symptoms of Common Mental Disorders in prison workers and persons deprived of their liberty	Recruitment completed	Intervention	2022-06-24	<NULL>	<NULL>	5446	Evaluation of the effect of Rosemary (Rosmarinus Officinalis) in the reduction of Common Mental Disorders in workers in the prison system and in persons deprived of their liberty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-20	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-102nsx22	<NULL>	Be a prison worker for at least one (1) year in one of the prison units that will be the location of this research; person deprived of liberty, with conviction and res judicata; agree to participate by signing the Free and Informed Consent Form	Not accepting to sign the Free and Informed Consent Form; present a medical diagnosis of mental illness that makes it difficult to understand the issues that make up the data collection instruments; patients using: diuretics, laxatives and hypotensives, with prostatic disease, gastroenteritis, dermatoses in general and with a history of seizures, chemically dependent patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5xp737h	Use of aromatherapy for anxiety and stress in the general community due to social isolation caused by the Covid-19 pandemic	Recruiting	Intervention	2022-06-23	<NULL>	<NULL>	5438	Aromatherapy in the face of anxiety and stress in the general population due to social isolation caused by the Covid-19 pandemic	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade de Franca	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)	https://ensaiosclinicos.gov.br/rg/RBR-5xp737h	<NULL>	Participants must be over 18 years old and less than 60 years old; They must reside in the city for at least 12 months; Present internet access with a valid email address or a valid WhatsApp number. Present a score above 8 on the Depression, Anxiety and Stress Scale anxiety test and above 10 on the general test.	Age within 18 years or above 60 years; Not residing in Franca/SP; Use benzodiazepines in the last 30 days; Use non-selective monoamine reuptake inhibitors (Imipramine, Clomipramine, Amitriptyline, Nortriptyline) , Serotonin Reuptake Inhibitors and ALPHA-2 (alfa2) Antagonists (Nefazodone, Trazodone), Selective Dopamine Reuptake Inhibitors (Bupropion), ALPHA-2 (alfa2) Antagonists (Mirtazapine), Monoamine Oxidase Inhibitors (Tranylcypromine, Moclobemide); Not having high blood pressure. Not being pregnant.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-5p27572	Comparison of dental and bone effects associated with Open Bite treatment with Orthodontic Appliance	Recruiting	Intervention	2022-06-23	<NULL>	<NULL>	5439	Dentoskeletal effects of Open Bite treatment with DAVIT (Dual Action Vertical Intra-arch Technique)	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-5p27572	<NULL>	Anterior open bite clinically greater than or equal to -1 mm; Class I malocclusion; permanent dentition; no need for dental extractions for treatment; absence of craniofacial anomalies; patients without aesthetic complaints of the face or indication for surgical correction of anterior open bite	Patients who do not perform the necessary pre-treatment exams for orthodontic treatment planning; patients who have a contraindication for the insertion of mini-implants.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-69px3cj	Comparison of arterial blood pressure drop after fast and slow infusion of propofol during general anesthesia	Recruiting	Intervention	2022-06-23	<NULL>	<NULL>	5440	Comparison of the incidence of arterial hypotension between propofol in target controlled infusion and bolus injection during induction of general anesthesia in young adults and non-cardiac surgeries - Randomized clinical trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2019-08-01	Universidade de Brasília	Faculdade de Medicina da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-69px3cj	<NULL>	35 to 55 year-old patients; elective surgery under general anesthesia; orotracheal intubation using direct laringoscopy; physical status I or II according to American Society of Anesthesiology classification	Data loss; infusion of drugs or doses out of the protocol; painful stimulus during protocol; refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-7tr9sbx	Efficacy potential of a behavioral intervention to promote adherence to oral antidiabetic drugs	Not yet recruiting	Intervention	2022-06-23	<NULL>	<NULL>	5441	Efficacy potential of a behavioral intervention to promote adherence to oral antidiabetic drugs	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de São João del Rei	Universidade Federal de São João del Rei	https://ensaiosclinicos.gov.br/rg/RBR-7tr9sbx	<NULL>	People with type 2 diabetes mellitus; 18 years of age or older; who have been using oral antidiabetic drugs for at least six months; are undergoing health monitoring in a health unit; with positive intention (greater than or equal to 4) to perform oral antidiabetic taking behavior; that have the ability to establish effective communication.	People who use insulin concomitantly with oral antidiabetics; that the administration of the medication is carried out by a caregiver.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-52ynn6j	Use of Pentoxifylline and Tocopherol before Tooth Extractions in Cancer patients undergoing treatment with bone Medications	Recruitment completed	Intervention	2022-06-23	<NULL>	<NULL>	5442	Use of Pentoxyphylline and Tocopherol prior to Tooth Extractions in Oncological patients submitted to treatment with Agents Bone Modifiers	<NULL>	2, n/a, open	2	<NULL>	<NULL>	<NULL>	2021-04-04	Instituto de Medicina Integral Professor Fernando Figueira - IMIP	Instituto de Medicina Integral Professor Fernando Figueira - IMIP	https://ensaiosclinicos.gov.br/rg/RBR-52ynn6j	<NULL>	Patients with a minimum age of 18 years; undergoing treatment with bone-modifying agents and requiring dental extractions	Patients who have a history of radiotherapy in the head and neck region; patients with obvious maxillary metastasis and patients who do not require tooth extractions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-437fmbz	Evaluation of the genital mucosa of a topical product under normal conditions	Data analysis completed	Intervention	2022-06-23	<NULL>	<NULL>	6409	Assessment of cutaneous and genital mucosa acceptability of a topical product under normal conditions of use	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2022-08-15	Allergisa  Pesquisa dermato-cosmética  ltda	Helianto Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-437fmbz	<NULL>	Healthy research participants; intact skin in the test region; agreement to adhere to the study procedures and requirements and to attend the institute on the day(s) and time(s) determined for the assessments; ability to consent to their participation in the study; age from 18 to 70 years; female survey participants	"Pregnancy or breastfeeding, having a menstrual period at the time of the study visits, skin pathology in the area of ​​application of the product, type 1 diabetes Mellitus, insulin-dependent diabetes, presence of complications due to diabetes (retinopathies, nephropathy, neuropathy); presence of diabetes-related dermatoses (plantar ulcer, necrobiosis lipoidica, granuloma annulare, opportunistic infections);
history of episodes of hypoglycemia, diabetic ketoacidosis and/or hyperosmolar coma, immune failure, Current use of the following topical or systemic medications: corticosteroids, immunosuppressants and antihistamines, skin diseases: vitiligo, psoriasis, atopic dermatitis, history of reaction to the category of product tested, other diseases or medications that may directly interfere with the study or put the health of the research participant at risk"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:42
RBR-8rtpfqx	Effects of aquatic exercise on the function of patients with amputation	Recruiting	Intervention	2022-06-22	<NULL>	<NULL>	5437	Influence of aquatic exercise on functionality, pain and postural balance in amputees: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-03	Associação de Pais e Amigos dos Excepcionais	Fundação Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8rtpfqx	<NULL>	Volunteer adults; aged 18 to 60 years; with unilateral lower limb amputation; transtibial or transfemoral; both genders; who are able to follow verbal commands; clinically stable	Neurological disorders; circulatory disorders; uncontrolled diabetes; patients on psychiatric medication; patients with infectious; contagious dermatological lesions; BMI ≥ 30	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-8rhkm25	Symptoms of obstruction and dimensions of the nasal cavity after Surgically Assisted Rapid Maxillary Expansion with 2 and 3 segments: randomized clinical trial	Recruitment completed	Intervention	2022-06-22	<NULL>	<NULL>	6547	Efficacy of Surgically Assisted Rapid Maxillary Expansion (SARME) with technique in two (2S) and three (3S) segments: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2014-02-03	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8rhkm25	<NULL>	Adult patients, literate and without cognitive impairment. Present maxillary transverse skeletal deficiency equal to or greater than 7 mm. Distance between the roots of the lateral incisors and maxillary canines of at least 1.2 mm so that osteotomies could be performed if the patient was randomized to the group with 3-segment osteotomies.	Patients with unilateral transverse maxillary skeletal deficiency. Presence of congenital craniofacial syndromes. Surgeries previously performed on the maxilla or nose. Diagnosis of possible nasal alterations such as the deviated septum, hypertrophy of the nasal turbinates, polyps, etc. Patient who had the expander loosened during the activation or retention period. Patients who did not perform any of the postoperative exams in their respective periods of analysis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:47
RBR-10k3pkd2	Study of the effects of Aerobic Physical Training on blood pressure and heart rate in men who had Covid-19	Not yet recruiting	Intervention	2022-06-21	<NULL>	<NULL>	5435	Study of the effect of Aerobic Physical Training on cardiorespiratory and metabolic parameters in individuals affected by Covid-19	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Faculdade de Medicina de Ribeirão Preto	Universidade de Franca - Unifran	https://ensaiosclinicos.gov.br/rg/RBR-10k3pkd2	<NULL>	Men and women; aged between 30 and 55 years; affected by Covid-19 in the mild form of the disease (treated at home); and in the severe form of the disease (required hospitalization); individuals who present any symptoms of the disease such as dyspnea; fatigue; respiratory and/or skeletal muscle weakness; among others.	Men and women who are in the period of transmission of the Covid-19 disease or who are undergoing previous home or outpatient physical therapy treatment; individuals with a cognitive disorder that prevents them from understanding the tests and training; musculoskeletal changes that make it impossible to perform tests and aerobic physical training; hemodynamic instability or that evolved with arrhythmias; smokers or who use drugs that interfere with cardiac functionality and cardiovascular autonomic control.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-10556nyj	Effect of biking at different timings on physiological and blood variations	Recruitment completed	Intervention	2022-06-21	<NULL>	<NULL>	5436	Effect of Temporal Deception on the metabolism of semi-professional cyclists	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-06-05	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-10556nyj	<NULL>	Cyclists; minimum of 2 years of experience; training three times a week; 2 or more competitions in the last year.	Medications or nutritional supplements users; Injury in the last 3 months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:07
RBR-33dd4p4	Electromyography or ultrasound: Benefit in guiding Botulinum Toxin injection in the treatment of Cervical dystonia	Recruiting	Intervention	2022-06-20	<NULL>	<NULL>	5433	Electromyography versus Ultrasound: Effectiveness in guiding the application of Botulinum Toxin in Cervical Dystonias	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Hospital Universitário Clementino Fraga Filho	Hospital Universitário Clementino Fraga Filho	https://ensaiosclinicos.gov.br/rg/RBR-33dd4p4	<NULL>	Volunteers with cervical dystonia; maximum 20 years of illness; both genders; age between 18 and 75 years old	Volunteers diagnosed with hematological pathologies; history of full anticoagulation; severe adverse reaction to botulinum toxin; unable to provide informed consent; cognitive and understanding impairment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-5pz9pwv	Description of ocular alterations in patientes with Sistemic Lupus Erythematosus	Recruiting	Observational	2022-06-20	<NULL>	<NULL>	5434	Prevalence of ophthalmologic alterations in patients with systemic lupus erythematosus	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-01	Universidade Federal da Bahia	Servicos Medicos de Oftalmologia - SEMOF	https://ensaiosclinicos.gov.br/rg/RBR-5pz9pwv	<NULL>	Patients with SLE will be recruited at the Rheumatology outpatient clinic of HUPES and must meet the inclusion criteria for SLE according to the American College of Rheumatology updated in 2019 (16).  Patients over 18 years of age followed at the Hupes Rheumatology outpatient clinic will be selected	Exclusion criteria will be patients presenting clinical diagnosis of another rheumatologic disease; HIV; HTLV; severe Arterial Hypertention; diabetes mellitus and individuals who have other ophthalmologic pathologies not related to SLE	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-6prps8g	HOTFy: randomised clinical trial to Hyperbaric Oxygen Therapy in Fibromyalgia	Not yet recruiting	Intervention	2022-06-17	<NULL>	<NULL>	5718	HOTFy: randomised clinical trial to Hyperbaric Oxygen Therapy in Fibromyalgia	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2022-12-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-6prps8g	<NULL>	ages between 18-70 years; diagnosis of fibromyalgia at least 2 years prior to enrollment based on one of two criteria: symptoms of generalized pain occurring above and below the waist and affecting the right and left sides of the body for at least 3 months and not having another somatic disorder that warrants the symptoms and/or presence of at least 11 of the 18 tender points (“Tender Points”).	contraindications for hyperbaric oxygen therapy (pregnancy, use of bleomycin, cisplatin, disulfiram and doxorubicin, middle ear surgery, untreated pneumothorax or pneumomediastinum, claustrophobia); associated autoimmune rheumatologic disease and inability to sign the informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:17
RBR-10kch7gy	Outcomes of the leg amputee of vascular origin welcomed in the hospital	Recruiting	Intervention	2022-06-15	<NULL>	<NULL>	5431	Clinical outcomes of lower extremity amputees of vascular origin admitted to the hospital environment: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade do Estado de Santa Catarina	Universidade do Estado de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10kch7gy	<NULL>	Syme, boyd, pirigoff, chopart, stripe, transmetatarsal and finger disarticulation, both unilateral and bilateral, in the immediate postoperative period; amputation for vascular cause; both sexes; age 18 years or older	The intervention group will be adopted as exclusion criteria: individuals with hemodynamic instability	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-48rdt69	The effect of Metformin on acute inflammation of the body during Periodontal Treatment in non-Diabetic patients	Recruiting	Intervention	2022-06-14	<NULL>	<NULL>	5429	Evaluation of the effect of glycemic control on acute systemic inflammation using oral Metformin during Periodontal Treatment in non-Diabetic patients. Pilot randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-20	Luciana Satie Okajima	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-48rdt69	<NULL>	Patients requiring periodontal treatment due to stage 3 or 4 generalized periodontitis, grade B or C; both genders; over 18 years old	Diabetic patients (Glicosilated hemoglobyn greater than 6.5%); pregnant women; patients who are breastfeeding; obese (body mass index greather than 29.9kg/m2); undergoing cancer treatment; taking immunosuppression medication; alcoholics; smokers; with renal failure; liver changes; congestive heart failure; history of acute myocardial infarction less than 6 months ago; respiratory changes (pneumonia, pulmonary embolism, asthma, chronic obstructive pulmonary disease); allergy to any component of the medication formula; when using any medication that may interfere with the protocol of treatment, for example anti-inflammatories or antibiotics will be excluded; individuals who do not agree to sign the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-4vmh6xg	Evaluating a full or fractional third dose Covid-19 vaccines in previously vaccinated adults	Recruiting	Intervention	2022-06-14	<NULL>	<NULL>	5430	A phase 4, single blind, randomised controlled trial to assess the immunogenicity, safety and reactogenicity of a third heterologous full or fractional booster dose Covid-19 vaccine in previously vaccinated adults	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2022-03-18	Centro de Estudos e Pesquisas em Moléstias Infecciosas LTDA - CePCLIN	University of Oxford	https://ensaiosclinicos.gov.br/rg/RBR-4vmh6xg	<NULL>	Males or females aged 18 years old or above; participants willing and able to comply with the study procedure; participants willing and able to provide informed consent prior to screening; participants who received two SinovacButantan vaccine doses at least 4 months, 120 days, prior to enrolment in this study, with a dose interval between each SinovacButantan dose of 14 to 35 days; for females of childbearing potential, willingness to practice continuous effective contraception during the study and a negative pregnancy test on the day) of screening and vaccination	Participants with fever more than 37.5 oC (axillary) or any acute disease at baseline (Day 1) or within the 3 days prior to randomization, febrile participants with mild diseases may be enrolled at the investigator’s discretion; participants with a recent history of COVID-19 (less or equal to 4 weeks prior to visit 1), laboratory confirmed; participants with a history of serious vaccine-related adverse reaction or serious allergic reaction (e.g., anaphylaxis) to any study vaccine component, as described in the last summary of product characteristics for Sinovac/Butantan, AstraZeneca/Fiocruz or Pfizer/Wyeth; participants with a known bleeding disorder that, in the investigator’s opinion, would contraindicate intramuscular injection; participants with any progressive or serious neurological disorder, seizure disorder or history of Guillian-Barré syndrome; participants given treatment with immunosuppressant therapy within the last 90 days, including cytotoxic agents or systemic corticosteroids or planned receipt during the study period, if a short-term cycle of immunosuppressant systemic corticosteroid dose has been used to treat acute disease, the participant should not be enrolled in the study until corticosteroid therapy has been discontinued for at least 15 days prior to the first study vaccination, in case the participant has been on an immunosuppressant dose of a depot, intramuscular or intra-articular corticosteroid, 60 days should be waited for their enrolment in the study. Inhaled/nebulized, intra-articular, intrabursal or topical (skin or eyes) corticosteroids are allowed; participants with autoimmune diseases, other than: Hashimoto thyroiditis, vitiligo, psoriasis, discoid lupus and the like; HIV-positive participants and/or in treatment for HIV; participants given any other investigational product within the 30 days prior to Day 1 or who intend to take part in another clinical trial at any time during this study conduction; participants given any other licensed vaccine within 14 days prior to enrolment in this study or who plan to receive any vaccine up to 28 days after vaccination; participants given treatment with Rituximab or any other anti-CD20 monoclonal antibody within 9 months prior to Day 1 or planned during the study period; administration of intravenous immunoglobulins and/or any blood products within 3 months prior to enrolment or planned dosing during the study period; participants with any condition that, in the investigator’s opinion, could interfere with the status primary objectives or represent an additional risk for the participant; participants who have received any other vaccine for Covid-19 other than two Sinovac/Butantan doses	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-7p8wzyr	Use of video games and conventional physical therapy to improve balance and postural control in patients with knee arthrosis: a randomized clinical trial	Not yet recruiting	Intervention	2022-06-11	<NULL>	<NULL>	5428	Virtual reality and kinesiotherapy for improving balance and postural adjustments in patients with knee osteoarthritis: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-10	Universidade Federal do Pará	Associação das Pioneiras Sociais	https://ensaiosclinicos.gov.br/rg/RBR-7p8wzyr	<NULL>	Female and male individuals, aged at least 18 years and diagnosed with knee osteoarthritis will be included.	Those who have a previous history of orthopedic surgery, fractures, neurological diseases, self-reported cognitive impairment that affects collection procedures, pregnancy, loss of protective foot sensitivity, individuals who are not clinically stable and who have contraindications to exercise will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-84r7q6r	Evaluation of blood glucose concentration and its effect on appetite and food consumption in healthy individuals	Data analysis completed	Intervention	2022-06-10	<NULL>	<NULL>	5424	Determination of the glycemic index and glycemic response of foods and their effect on appetite and food intake in eutrophic and euglycemic individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-05	Universidade Federal de Viçosa	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-84r7q6r	<NULL>	Normal-weight individuals (body mass index ranging from 18.5 to 24.9 kg/m² and body fat percentage from 12 to 20% for males and 20 to 30% for females) (Sociedad Española para el Estudio de la Obesidad, 2000); non-smokers; non-pregnant women or lactating women; and who present fasting glucose ranging from 70 to 99 mg/dl.	Type 1 or 2 diabetes; family history of first-degree diabetes mellitus; recent digestive, liver, kidney, cardiovascular, thyroid, or inflammatory diseases; alcohol intake greater than two doses (greater than 20 ml) per day; weight instability (gain or loss of more than 3 kg in the last 3 months); being on a diet to control weight; use medications that affect metabolism and have an allergy or aversion to the tested foods.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-79fbccw	A new technique for treating gummy smile with the use of polyester thread	Recruitment completed	Intervention	2022-06-10	<NULL>	<NULL>	5425	Clinical evaluation of the lip repositioning technique using polyester thread for gummy smile treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-10	São Leopoldo Mandic	Instituto Militar de Engenharia	https://ensaiosclinicos.gov.br/rg/RBR-79fbccw	<NULL>	Healthy patients dissatisfied with a gummy smile; a minimal gingival exposition of 4mm	Patients with periodontal disease; pregnant and lactating women; smoking; systemic health problems; use of chronic medication that interferes in the gingival healing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-965656g	Effect of muscle training on pain and functionality in elderly people with knee wear	Recruitment completed	Intervention	2022-06-10	<NULL>	<NULL>	5426	Effect of Training Protocols on Chronic Pain and Physical Function in Older People witjh Osteoarthritis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-27	Carla Mariza de Lima Krieger	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-965656g	<NULL>	Volunteers of both genders; be 60 years of age or older; be able to perform physical exercises, according to medical evaluation; having knee osteoarthritis in one or both knees (according to the American College of Rheumatology); present grade ≤ 3 according to the Kellgren-Laurence Grading Scale (Kellgren et al., 1957); refer chronic pain for more than 3 months (according to the IASP - International Association for the Study of Pain concept) in one or both knees, with referred pain ≥ 3, according to the Visual Analogue Scale (VAS).	Pacemaker wearers; having fibromyalgia; carrier of any oncological disease; having some systemic/general and/or cognitive impairment or neurological disorder; having undergone knee surgery and/or intra-articular corticosteroid injection within 6 months; any other muscular, joint or neurological condition that affects the function of the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-65zd2v4	Profile of patients with fecal leakage and suggestion of physiotherapeutic treatment for patients with bowel complaints and leakage of feces	Data analysis completed	Observational	2022-06-10	<NULL>	<NULL>	5427	"Constipation and Fecal Incontinence:
Phase I - Profile of patients complaining of constipation and fecal incontinence
Phase II - Elaboration and implementation of a physiotherapeutic treatment protocol in patients with constipation complaints"	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-05	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-65zd2v4	<NULL>	Study group: patients with complaints of constipation and patients with fecal incontinence; in the control group und without pelvic dysfunctions; everyone over 18 years old; who signed the Free and Informed Consent Term (ICF).	Individuals with cognitive impairment; individuals without constipation and fecal incontinence in the study group; in the control group individuals who had pelvic complaints. In both groups, individuals with: untreated respiratory diseases, visual alteration (without correction), acute vestibular and orthopedic alterations, practice of intense physical exercise (athletes).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-9ydn4bn	Influence of actn3 and ppar alpha gene variations on recovery from oxidative stress, muscle wastage and post-exercise physical performance in response to beetroot juice supplementation	Data analysis completed	Intervention	2022-06-09	<NULL>	<NULL>	5421	Influence of actn3 and ppar alpha gene polymorphisms on recovery from oxidative stress, muscle wasting and post-exercise physical performance in response to beetroot juice supplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-02	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-9ydn4bn	<NULL>	Runners for at least one year; be performing uninterrupted training for at least three months; train with the aim of participating in long-term running competitions.	Volunteers who had some chronic degenerative disease; smokers; who made continuous use of any medication; did not participate in all experimental procedures; presented gastrointestinal discomfort to beet juice or control drink.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-5zkjsgj	"Identification of fungi in users of dentures by cheap
molecular methods"	Recruiting	Observational	2022-06-09	<NULL>	<NULL>	5422	"Identification of Candida spp. in users of removable dentures by low-cost
molecular methods"	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-15	Universidade Estadual Paulista Julio Mesquita Filho	Universidade Estadual Paulista Julio Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-5zkjsgj	<NULL>	Volunteers of both sexes; from 30 to 90 years; upper complete denture wearers; with or without prosthetic stomatitis	Use of antibiotics; antifungals in the last 3 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-69p7mpr	Clinical evaluation of dental adhesives applied in different techniques in non-carious cervical lesions	Recruiting	Intervention	2022-06-09	<NULL>	<NULL>	5423	Clinical Evaluation of Clearfil S3 Bond Universal Quick applied in different techniques in non-carious cervical lesions	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Andres Felipe felipe Millan Cardenas	Centro Universitário de Maranhão - UNICEUMA	https://ensaiosclinicos.gov.br/rg/RBR-69p7mpr	<NULL>	Age between 18-50 years old; Participants must have at least three comparable LCNCs (in size, shape, and dimensions) to be restored; These lesions must be non-retentive, deeper than 1 mm, and involve both enamel and dentin of vital teeth without periodontal disease; Acceptable oral hygiene and have at least 20 teeth under occlusion.	The cavo-superficial margin cannot involve more than 50% of the enamel; Extremely poor oral hygiene or using orthodontic treatment; Severe or chronic periodontitis or heavy bruxism habits; Known allergy to resin-based materials or any other material used in this study; Pregnant or lactating women; Patients with chronic use of anti-inflammatory, analgesic and psychotropic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-523hrsx	Telescreening for urgent care in Pediatric Dentistry	Recruiting	Intervention	2022-06-08	<NULL>	<NULL>	5417	Dental emergency remote screening in children using questionnaire - before and after study nested to randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	FOUSP - Faculdade de Odontologia da Universidade de São Paulo	Prefeitura Municipal de Carangola	https://ensaiosclinicos.gov.br/rg/RBR-523hrsx	<NULL>	Children 03 to 13 years of age, with dental pain who seek emergency care in Dental Clinics; Have enough internet for synchronous consultation;Signature of the Informed Consent Form; Have agreed to participate in the research	Do not attend the face-to-face consultation, when allocated in group G2; Problems with the internet;Did not sign the free and informed consent form;Do not agree to participate in the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-3ydggrz	Development of a measure to help predict intubation difficulty Distance from skin to epiglottis	Data analysis completed	Observational	2022-06-08	<NULL>	<NULL>	5418	Development of a new measure to predict difficult airway obtained by ultrasound: cutaneous-epiglottic distance. observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-02	Universidade Estadual Paulista - UNESP	Fundação Centro Médico de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3ydggrz	<NULL>	Adult patients of both sexes who will undergo general anesthesia under tracheal intubation	Obese patients with a BMI greater than 35kg/m2, with obstructive sleep apnea, with a previous history of difficult tracheal intubation or who have any predictive sign of difficult intubation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-3hwn66w	Surgical treatment of Dupuytren&apos;s disease: A comparison between two surgical approaches	Terminated	Intervention	2022-06-08	<NULL>	<NULL>	5419	Surgical treatment of Dupuytren&apos;s disease: A Randomized clinical trial comparing techniques of partial fasciectomy by Bruner-type surgical access versus zetaplasty	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-09-21	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3hwn66w	<NULL>	Adult patients from both sexes; with the diagnostic of Dupuytren; with indication for surgical treatment, defined as the inability to open de palm of the hand on a flat surface	Patients with previous surgery in the hand; diseases that affect hand function; contraindications to surgical procedure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-6rwy7my	Impact of different clinical criteria in the evaluation of caries lesions around restorations in deciduous teeth	Recruitment completed	Intervention	2022-06-08	<NULL>	<NULL>	5420	Impact of different clinical criteria in the evaluation of caries lesions around restorations in primary teeth: a randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2020-12-07	Universidade de São Paulo	Universidade Cruzeiro do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6rwy7my	<NULL>	All patients (160) included in the CARDEC-3  (Caries Detection in Children - 3) study (Moro et al., 2020) were invited to participate in the study.	Children with health problems or whose parents are illiterate or do not accept to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-104sqkyp	Are there relationship between the amount of creatine in the diet and memory in the elderly?	Recruiting	Observational	2022-06-03	<NULL>	<NULL>	5416	Are there correlations between the amount of creatine in the diet and short-term visuospatial memory in the elderly? The observational study	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-05	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-104sqkyp	<NULL>	Elderly more than 60 years old; physically active; healthy; both genres	Elderly people with cognitive impairment (MMSE more than 20); who use nutritional supplements; who are illiterate; or who use medications that affect cognition cannot participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-4tpkszn	Effects of Physiotherapy on immunity in patients with lymphedema	Recruitment completed	Intervention	2022-06-02	<NULL>	<NULL>	5415	Effect of Complex Decongestive Therapy on immune response parameters in individuals with lymphedema	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-09	Fundação de Amparo à Ciência e Tecnologia de Pernambuco (FACEPE)	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-4tpkszn	<NULL>	Individuals of both sexes; be over 18 years of age; present lymphedema in lower limbs in stages II or III according to Mowlen (1948)	Patients with lymphedema undergoing treatment with chronic use of oral anti-inflammatory drugs or corticosteroids; with active and untreated infectious processes during study recruitment; who had thrombophlebitis; diabetes; skin rashes; open wounds; urinary and/or fecal incontinence and contraindications for manual lymphatic drainage and for compressive bandaging	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-6vbfszv	Analysis of Syringe Identification Pattern for Medication Administration during Anesthesia and its association with medication errors	Not yet recruiting	Observational	2022-06-01	<NULL>	<NULL>	5414	Analysis of Syringe Identification Pattern for Drug Administration during Anesthesia in Brazil and its association with medication errors in the perioperative period	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-09-12	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	Departamento de Anestesiologia da Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6vbfszv	<NULL>	Training anesthesiologists will be included; as well as those already trained; of public and private hospitals in different Brazilian regions	Anesthesiologists who refuse to sign the consent form or who show prior knowledge of the study to be carried out will be excluded from the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-10scxbgv	The effect of physical exercise on the quality of life of postpartum women	Recruitment completed	Intervention	2022-05-31	<NULL>	<NULL>	5411	Recovery of women&apos;s pelvic floor in the postpartum: a question of quality of life	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Estadual de Ponta Grossa	Hospital Universitário Materno Infantil - HUMAI	https://ensaiosclinicos.gov.br/rg/RBR-10scxbgv	<NULL>	Women aged 18 and over; having had a cesarean or vaginal delivery at the Hospital Materno Infantil de Ponta Grossa; present discomfort related to pelvic floor dysfunctions; present a medical certificate, if necessary	Women with acute or chronic physical conditions that result in loss of motor, physiological and/or cognitive abilities, for example, spinal cord injuries and neurodegenerative diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-8q65vps	Effect of a treatment for upper limb and language in post-stroke patients	Recruiting	Intervention	2022-05-31	<NULL>	<NULL>	5412	Relationship between motor skill and language post-stroke and use of neuromodulation associated with peripheral therapies to improve movement, manual function and language	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-20	Universidade Federal de Sergipe	Programa de Pós-graduação em ciências aplicadas à Saúde (PPGCAS)	https://ensaiosclinicos.gov.br/rg/RBR-8q65vps	<NULL>	Patients aged between 30 and 80 years will be included; of both sexes, diagnosis of ischemic or hemorrhagic stroke confirmed by computed tomography or magnetic resonance imaging, absence of cognitive deficits (assessed by the MMSE - Mini Mental State Examination, score greater than 18 ; All degrees of motor impairment according to the classification Fugl-Meyer score (total score 0 to 66 points): severe (Fugl-Meyer score 0 to 15 points), severe or moderate (16 to 34 Fugl-Meyer points), moderate/mild (35-53 Fugl points -Meyer) and mild (54 to 66 Fugl Meyer points); Aphasic patients will be evaluated by the Boston Naming Test and Montreal-Toulouse Battery Test (MTL-Brazil), in all degrees of impairment: alert for neuropsychological deficit (- 1.0 and -1.5), moderate to severe deficit (-1.6 and -2.0), presence of very severe deficit (less than or equal to -2.0), does not suggest cognitive deficit (greater than - 1.0)	Patients who present the following conditions will be excluded: clinical evidence of multiple brain lesions or other associated neurological diseases; peripheral neuropathies, leprosy, fibromyalgia, rheumatoid arthritis; other upper and lower motor neuron pathologies; history of psychiatric illness including drug and alcohol abuse; orthopedic deformities installed in the upper limbs. Those who are undergoing rehabilitation treatment during the collection (Occupational Physiotherapy and/or Speech Therapy) will not participate in the research. Patients with receptive types of aphasia (assessed by the MTL-Brazil test) will also be excluded. In addition to these, due to contraindication for the application of tDCS, patients with intracranial metallic implants will be excluded; pregnancy; use of medication that interferes with cortical excitability; history of seizures and/or epilepsy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-5z58rzp	Continued use of extra virgin Olive Oil fat solution during Hemodialysis session to decrease inflammation in patients with Chronic Kidney disease	Recruitment completed	Intervention	2022-05-31	<NULL>	<NULL>	5413	Continued use of Lipid Emulsion with extra virgin Olive Oil, Intradialytic, to decrease the inflammatory state in Chronic Kidney patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-31	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade de Jaén	https://ensaiosclinicos.gov.br/rg/RBR-5z58rzp	<NULL>	All patients over 18 years of age; more than six months in hemodialysis treatment; with adequate dialysis index greater than 1.2	Not accepting to be part of the research; chemotherapy or radiotherapy in the last three months; corticosteroid therapy greater than 7.5 mg/d; acute bacterial infection; impairment of vascular access; severe liver failure; acute immunodeficiency virus; severe hypertriglyceridemia above 400 mg; difficulty in adjusting blood glucose; pregnancy; hypersensitivity to any component of the lipid emulsion; intrahepatic cholestasis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-5hrnpd5	Effect of aromatherapy with Lavender on satisfaction with childbirth	Recruitment completed	Intervention	2022-05-30	<NULL>	<NULL>	5410	Evaluation of the possible benefit of the effect of Lavandula angustifolia on satisfaction with childbirth and postpartum in women treated at the maternity of regional hospital from São José - SC	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5hrnpd5	<NULL>	Pregnant women; primiparous; active labor	required cesarean section; glucocorticoids use in the last 30 days;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-3tqyhrz	Extraoral Infrared Laser therapy application after Wisdom tooth extraction	Terminated	Intervention	2022-05-29	<NULL>	<NULL>	5409	Extraoral Infra-red Photobiomodulation in the postoperative period of lower third molar extraction	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-11	Faculdade de Odontologia da Universidade de São Paulo	Faculdade de Odontologia da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3tqyhrz	<NULL>	Healthy patients of both genders, between 18 and 35 years old, who had the necessity of bilateral lower third molar extraction with similar clinical and radiographic characteristics by Winter and Pell and Gregory classification were recruited.	We did not include individuals who had used analgesic or anti-inflammatory drugs in the last 15 days, underwent previous surgery in the region of the lower third molar, or had inflammatory conditions in the region of the lower third molar. If there were significant differences operative lasting between the groups, intraoperative complications, postoperative complications, or patient did not return in the postoperative period, data from those cases were excluded from the final sample.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-10s75n9x	Evaluation of the use of the COVISTIX/COVIMARK rapid test for identification of COVID-19 virus (coronavirus) by lay people	Not yet recruiting	Intervention	2022-05-27	<NULL>	<NULL>	5408	Usability evaluation of the rapid SARS-CoV-2 antigen detection self-test (COVISTIX/COVIMARK) by lay subjects	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	CAEP - Centro Avançado de Estudos e Pesquisas	CAEP - Centro Avançado de Estudos e Pesquisas	https://ensaiosclinicos.gov.br/rg/RBR-10s75n9x	<NULL>	Cohort A - Adult subjects over 18 years old, of both sexes; be able to sign the ICF approved by the EC and to execute and understand all the procedures and instructions of the study; presenting suspected flu-like symptoms of COVID-19 with an onset of 5 days or less; or having had contact with a person infected with SARS-CoV-2 within 14 days; Cohort B - Adult subjects over 18 years of age, of both sexes; be able to sign the ICF approved by the EC and execute and understand all assay procedures and instructions; previous positive test for COVID-19 less than 2 days; if the subject is symptomatic for COVID-19, the symptoms are of mild to moderate intensity; be immunized with at least two doses of the COVID-19 vaccine; availability of maintaining isolation for up to 9 days from the signing of the ICF, to perform the self-test at home and home collection of RT-PCR for SARS-CoV-2 at the end of the study; be able to photograph the cassettes with the test result and sending the images to the research center, daily	Cohort A - Present a diagnosis of COVID-19 with symptoms of severe acute respiratory syndrome; presence of nasal obstruction that prevents swab collection; participation in a clinical trial in the previous twelve months; any condition that, in the investigator&apos;s judgment, precludes participation for reasons of subject safety or data integrity; Cohort B - Having a negative result in the self-test with COVISTIX/COVIMARK during the selection visit; being immunocompromised or using an immunosuppressant; having chronic diseases such as diabetes, hypertension, asthma, chronic obstructive pulmonary disease, obesity; having a diagnosis of COVID-19 with symptoms of severe acute respiratory syndrome; presence of serious symptoms or symptoms that require hospital care; previous positive test for SARS-CoV-2 infection or confirmed diagnosis of COVID-19 more than 2 days; being hospitalized or requiring hospitalization; inability to maintain isolation for up to 9 days after signing the ICF, for conducting the self-test at home and collecting a nasal swab at home of RT-PCR for SARS-CoV-2 at the end of the study; inability to photograph cassettes with test results and send the images to the study center daily; presence of nasal obstruction that prevents swab collection; - participation in a clinical trial in the previous twelve months; any condition that, in the investigator’s judgment, precludes participation for reasons of subject safety or data integrity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:06
RBR-2znphfj	Efficacy of Acupuncture in the pinna to reduce Anxiety in Primary Health Care professionals	Not yet recruiting	Intervention	2022-05-26	<NULL>	<NULL>	5406	Efficacy of Auriculotherapy to reduce Anxiety in Primary Health Care professionals	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-06	Anny Caroline Santos Almeida	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-2znphfj	<NULL>	All PHC health professionals in the city of Lagarto Sergipe. Assent to participation by means of a Free and Informed Consent Term. Have moderate or severe levels of anxiety, according to the State Trait Anxiety Inventory	Professionals with scheduled vacations during the research period. On sick leave. pregnant women Allergic to tape and micropore. Those who at the time of the study are using anxiolytics focus on the treatment of anxiety	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-8txr4fw	Clinical evaluation of a monochromatic composite resin of dental restoration	Recruiting	Intervention	2022-05-26	<NULL>	<NULL>	5407	Clinical evaluation of a monochromatic composite resin	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8txr4fw	<NULL>	Good general health; good oral hygiene; have at least 20 teeth under occlusion. At least two comparable non-carious cervical lesion (in size; shape and dimensions); non-retentive; deeper than 0.5 mm; and involving both enamel and dentin of vital teeth. The cavo-superficial margin cannot involve more than 50% of the enamel	Extremely poor oral hygiene; using orthodontic devices; severe or chronic periodontitis; heavy bruxism habits. Known allergy to resin-based materials or any other material used in this study. Pregnant or lactating women; chronic use of anti-inflammatory; analgesic and psychotropic drugs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-8cb536g	Effects of Omega-3 Supplementation, associated or not with Physical Exercise in patients with Metabolic Syndrome	Not yet recruiting	Intervention	2022-05-24	<NULL>	<NULL>	5402	Effects of Omega-3 Supplementation, associated or not with High-intensity Physical Training on anthropometric, physiological, biochemical and molecular parameters in patients with Metabolic Syndrome	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-8cb536g	<NULL>	Both sexes; age between 20 and 60 years; diagnosis of grade I obesity (Body Mass Index between 30.0 and 34.9 kg/m²) and type 2 diabetes mellitus; exclusive use of metformin; no evidence of coronary artery disease (history of angina, history of myocardial infarction or acute coronary syndrome, history of abnormal segmental motion of the heart wall on echocardiography); no bowel disease (short bowel syndrome, irritable bowel syndrome, Chron&apos;s disease, ulcerative colitis, celiac disease, colorectal cancer); no diseases related to the central nervous system (Alzheimer&apos;s, Parkinson&apos;s, hepatic encephalopathy, autism spectrum disorders); physical inactivity according to the International Physical Activity Questionnaire (short version); signing the informed consent form (ICF).	Individuals with musculoskeletal or cardiovascular limitations that make physical exercise impossible; fasting blood glucose greater than 300 mg/dl; use of any drug of continuous use for less than 3 months (except metformin); use of antibiotics, non-steroidal anti-inflammatory drugs or corticosteroids in the last month; use vitamin/food supplements that contain omega-3; individuals with genetic and hormonal limiting disease; abuse of alcohol and drugs; retinopathy; pregnancy or lactation; life expectancy less than 6 months (example: metastatic malignant neoplasm); patients with renal failure or congestive heart failure; individuals with previous organ transplants; wheelchair users; individuals with weight loss in the last 3 months (voluntary or not); volunteers in another experimental study on the date of enrollment; individuals who do not have access to the internet; discontinuation of omega-3/placebo use for 3 consecutive days; non-compliance with the physical activity protocol for 2 consecutive sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-9nv2h42	Assessing brain health in adults and older adults	Recruiting	Observational	2022-05-24	<NULL>	<NULL>	5403	Characterization of normality curves of non-invasive intracranial pressure in adult and elderly individuals	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-18	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9nv2h42	<NULL>	Age between 25 and 60 years for the adult group and over 60 and up to 80 years for the elderly group; healthy; through confirmation by blood count and biochemical examination; and do not use controlled medications.	Idiopathic intracranial hypertension; chronic diseases (hypertension; cardiovascular or metabolic diseases; arrhythmias; migraine; cerebrovascular or neurodegenerative diseases and genetic diseases); present risk factors for cardiovascular diseases (BMI&gt;30 kg/m²; LDL&lt;130 mg/dl; smoker; alcoholic; substance abuser or waist circumference greater than 94 cm for men and 80 cm for women, according to recommendations of the Brazilian Ministry of Health ).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-37yq8r6	Effect of the medication Buspirone Hydrochloride on the frequency of teeth grinding secondary to Anxiety	Recruiting	Intervention	2022-05-24	<NULL>	<NULL>	5404	Effect of Buspirone Hydrochloride on the frequency of Bruxism as a somatic manifestation of Anxiety: randomized double-blind placebo-controlled clinical trial	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-37yq8r6	<NULL>	Both sexes; Older than 18 years; Diagnosis of probable sleep bruxism and definite awake bruxism	"Under 18 years old; Epilepsy and seizure; Acute intoxication and/or chronic use of alcohol, hypnotics, analgesics, or antipsychotic drugs; Smokers; Consumption of more than three cups of coffee per day; Severe kidney and liver failure;
• Severe neurological or psychiatric disorders; History of chronic musculoskeletal pain; Previous diagnosis or signs and symptoms of chronic TMD and sleep disorders (snoring, sleep apnea, and periodic limb movement); Use of prescription drugs or drugs with possible effects on sleep or changes in motor behavior or drug interactions with buspirone hydrochloride; Gastroesophageal reflux; Enlarged tonsils; BMI &gt; 30; Allergy to electrode gel; Currently undergoing medical or dental treatment; Pregnant women; Users of pacemaker or implanted defibrillator; Loss of more than two posterior teeth, except third molars; Users of complete dentures, removable partial dentures and orthodontic appliances; Skeletal Class II"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-8kjtfx3	Empathy training and the effects on the psychological impact of caregivers of the elderly: a randomized clinical trial	Recruiting	Intervention	2022-05-24	<NULL>	<NULL>	5405	Effects of empathy training on levels of burden in caregivers of older people	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-8kjtfx3	<NULL>	Present a score equal to or greater than 23 on the Zarit Burden Scale; perform the role of caregiver of an elderly person for at least three months; carry out their activities for at least four hours a day and be of legal age	Care that presents deficits that make it impossible to understand the tests; caregivers who are not available to participate in all stages of the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-4yjvpxg	Effects of a Group Intervention to prevent Post-traumatic stress disorder linked to childbirth: a comparative study between two groups of high-risk pregnant women	Not yet recruiting	Intervention	2022-05-23	<NULL>	<NULL>	5401	Evaluating the effectiveness of a Brief Intervention for Post-traumatic stress disorder associated with childbirth/birth: a clinical, randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-04	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4yjvpxg	<NULL>	The pregnant women must be 18 years of age or older; being in the third trimester of pregnancy (between 28 and 32 weeks of gestation); no history of previous (self-reported) mental disorders, except for common mental disorders and current ones (score on the Self Report Questionnaire less than 7), score on the Health Questionnaire of the Patient-9 less than 10 and General Anxiety Disorder Questionnaire-7 score less than 10; not being in psychological and psychiatric treatment at the time of data collection; and agree to voluntary participation in the study, signing the Free and Informed Consent Form	Women who drop out of the study at any stage of data collection before the conclusion of the same; do not attend the sessions for the application of the assessment instruments or the meetings of the intervention group, regardless of the reason; and are not found after the pregnancy is resolved by the telephone and/or e-mail provided by them for the evaluation of outcomes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-75jm4cj	Carvedilol as a single-drug therapy for Heart Failure with recovered ejection fraction: an open label randomized clinical trial	Recruiting	Intervention	2022-05-20	<NULL>	<NULL>	6047	Open-label, pilot, randomized clinical trial evaluating the effect of withdrawing renin-angiotensin-system inhibitors and neprilisin inhibitors and maintaining Carvedilol in Heart Failure with recovered ejection fraction	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2022-04-12	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-75jm4cj	<NULL>	Patients with previous diagnosis of reduced ejection fraction heart failure and documented ejection fraction equal or under 40% and actual ejection fraction equal or more than 50% and 10% greater than previous; Age equal or greater than 18 years old; absence of symptoms related to heart failure; Currently using carvedilol and angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers or neprilisin inhibitor with or without spironolactone; NT-proBNP under 250pg/mL; heart rate between 50 and 60 or maximum tolerated dose of carvedilol after runin fase or at least 50mg/day of carvedilol.	Ischemic cardiomyopathy; hypertensive cardiomyopathy: stage 3 hypertension as defined by the Brazilian Guideline of Hypertension or current blood pressure higher than 160x90mmHg; chagasic cardiomyopathy; valvar cardiomyopathy; infiltrative cardiomyopathy; chronic renal disease with creatinine clearance less than 30mL/min/1,73m²; formal indication for angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers such as diabetic patients with hypertension, diabetic nephropathy or another nephropathy with proteinuria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:29
RBR-8q6z6kq	Effect of Bach Flower treatment on hope and quality of life in patients with Advanced Cancer	Not yet recruiting	Intervention	2022-05-19	<NULL>	<NULL>	5400	Effectiveness of Bach Flower therapy on hope and health-related quality of life of patients with Advanced Cancer: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Leonel dos Santos Silva	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8q6z6kq	<NULL>	Be over 18 years old; have a histologically proven diagnosis of any type of advanced (stage IV) cancer; Eastern Cooperative Oncology Group (ECOG): 0, 1, 2 or 3 characterized as: 0 (fully active); 1 (restricted from strenuous physical activity and able to perform work of a light or sedentary nature); 2 (self-care capacity without working conditions, remains out of bed 50% of the time) and 3 (limited self-care capacity, remains 50% of the time in bed or chair rest)	Continuous use of anxiolytic and antidepressant medications; use of some integrative or complementary health practice such as flower essences, chromotherapy, aromatherapy, acupuncture, reiki, therapeutic touch, among others; unable to maintain verbal and/or written communication by the assessment of the Eastern Cooperative Oncology Group (ECOG) 4 performance scale (completely limited and unable to perform self-care activities, totally confined to bed or chair)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-7nkf8tn	Response to the Clinical Treatment of Tubal Pregnancy	Recruiting	Intervention	2022-05-18	<NULL>	<NULL>	5398	Clinical Treatment of Ectopic Pregnancy - Response to the intravenous administration of Methotrexate	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-13	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7nkf8tn	<NULL>	Stable patients diagnosed with ectopic pregnancy; beta-hCG levels below 5000 mU/mL; unruptured gestacional sac/mass; gestacional sac/mass below 4cm of length; no sign of fetal heartbeat on the ultrasound	Patients that don&apos;t fill the criteria for clinical treatment; patients who don&apos;t agree with the Informed Consent Form after reading and comprehending it	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-899j6kt	Endodontic Treatment  in oncologic patients	Recruiting	Intervention	2022-05-18	<NULL>	<NULL>	5399	Endodontic Treatment management in oncologic patients	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-01-10	Universidade do Grande Rio	Universidade do Grande Rio	https://ensaiosclinicos.gov.br/rg/RBR-899j6kt	<NULL>	Patients with teeth presenting periradicular endodontic compromise; oncologic patients; patients aged between 18 and 80 years.	"Patient who will not be available for proservation visits; patients who have received antibiotic therapy in the last 3 months; patients who have any condition that limits their survival to less than 3 months.
patient who is unable to understand and co-operate with study procedures or to provide informed consent."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-2wdjcdv	The Klivo Intervention Program: a digital platform to monitor patients with type 2 diabetes mellitus	Not yet recruiting	Intervention	2022-05-17	<NULL>	<NULL>	5396	The Klivo Intervention Program protocol: management of type 2 diabetes mellitus through a digital platform	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Klivo Licenciamento Ltda.	Klivo Licenciamento Ltda.	https://ensaiosclinicos.gov.br/rg/RBR-2wdjcdv	<NULL>	Diagnosis of type 2 diabetes mellitus in the electronic medical record of health plans and healthcare provider organizations (HbA1c reading 7% or higher; aged between 18 and 65 years). Willingness to receive phone calls and messages for monitoring the disease and for tele-education. Willingness to use the standard monitoring devices (glucometer), synchronized with the telemonitoring system according to the study protocol throughout the 12-month study period.	Cognitive impairment based on a diagnosis of dementia or mild cognitive impairment reported in the medical records. Self-declared reluctance to receive phone calls or messages for disease management. Pre-existing condition: chronic kidney disease stage 5; individuals with any end-stage disease with a life prognosis of fewer than two years; or pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-6d8whb5	Comparison of the effect of Conventional and Laser Cataract Surgery on the eye of Diabetic patients	Recruitment completed	Intervention	2022-05-17	<NULL>	<NULL>	5397	Comparative analysis of corneal endothelial cell loss among Diabetic patients undergoing Conventional Phacoemulsification and Femtosecond Laser-Assisted Cataract Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Hospital Oftalmológico Visão Laser	Hospital Oftalmológico Visão Laser	https://ensaiosclinicos.gov.br/rg/RBR-6d8whb5	<NULL>	Cataracts with nuclear density 2+ and 3+ graded by the Lens Opacity Classification System III (LOCS III)	Traumatic cataract; mature and hypermature cataracts; grade 4 nuclear cataract; pseudoexfoliation syndrome; conjunctival scar; significant corneal opacity; glaucoma; ocular hypertension; uveitis; vitreoretinal pathology; previous intraocular surgery; intraoperative complications during cataract surgery; collagen vascular disease; any active eye disease; high myopia; high hyperopia (axial length less than 15 mm); age under 40 years; preoperative cell count less than 1,000 cells per square millimeter or preoperative anterior chamber depth less than 2.5 mm; dry eye syndrome; neovascularization of the iris.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-7m3rvth	Leucine supplementation in cancer patients and its effect on inflammation	Recruitment completed	Intervention	2022-05-16	<NULL>	<NULL>	5395	Modulation of the inflammatory profile in Cancer patients supplemented with Leucine	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2018-03-10	Márcia Fábia Andrade Santos	Ajinomoto do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-7m3rvth	<NULL>	Patients with head and neck cancer (CCP) histologically confirmed by biopsy and pathological anatomy, with weight loss above 5% in the last 12 months or body mass index (BMI)  less than 20 kg/m²	Obesity (BMI equal or greater than 30kg/m²); preexisting inflammatory diseases; autoimmune diseases; chronic use of anti-inflammatory drugs and/or steroids; unbalanced diabetes mellitus; use of protein supplements; regular physical activity; use of probe for feeding.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-7ss6856	Face-to-face or telerehabilitation rehabilitation in post-Covid patients: a randomized trial	Recruitment completed	Intervention	2022-05-13	<NULL>	<NULL>	5393	Follow-up and rehabilitation of post-Covid patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI	https://ensaiosclinicos.gov.br/rg/RBR-7ss6856	<NULL>	Patients who have been infected with coronavirus 19; Patients referred to UNIJUI Saúde after medical clearance with no risk of contamination (positive IGG ie no risk of contamination); between 18 to 80 years of age.	Patients who do not want to participate in the research; Recent neuromuscular disease (within the last 3 months); Unable to understand and follow research procedures or protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-5328h8g	Effect of high and low volume of specific training for the trunk in chronic low back pain	Not yet recruiting	Intervention	2022-05-13	<NULL>	<NULL>	5394	Neuroimmunoendocrine effects of core stabilization training in women with chronic non-specific lumbar pain: randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-08-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5328h8g	<NULL>	Women with a clinical diagnosis of chronic nonspecific low back pain; age between 18 and 59 years; complaint of low back pain for more than 3 months; pain level greater than 3 on the 11-point numerical pain scale; body mass index (BMI) &lt;30 kg/m2; not having undergone spinal surgery; not practicing physical exercise regularly; not having physical therapy or other pain treatment; not taking analgesic, anti-inflammatory, opioid or immunosuppressive medication	Missing one of the assessments; missing more than 10% of the intervention; have any motor, psychiatric or cognitive impairment; have hearing, visual or communication disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-1047fwbf	Can the antibiotic Doxycycline help control the complications (dyskinesias) of levodopa treatment in patients with Parkinson&apos;s Disease?	Recruitment completed	Intervention	2022-05-12	<NULL>	<NULL>	5391	Pilot study to verify the safety and efficacy of Doxycycline in the treatment of levodopa-induced dyskinesias in patients with Parkinson&apos;s disease	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2021-03-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-1047fwbf	<NULL>	Patients 18 years of age or older; diagnosed with Parkinson&apos;s disease according to the United Kingdon Parkinson&apos;s Disease Society Brain Bank clinical diagnostic criteria; presenting at the initial evaluation with at least some functional impact dyskinesias (score higer than1 on item 4. 2 of the Movement Disorder Society - Unified Parkinson&apos;s Disease Rating Scale (MDS-UPDRS); who are using levodopa at least three times a day; and who can keep doses of antiparkinsonian medications unchanged for at least four weeks prior to screening and during study participation.	Diagnosis of atypical or secondary parkinsonism; treatment of any experimental drug or other intervention within 90 days prior to screening or baseline assessment; presence of moderate or severe psychotic symptoms (score greater than 2 on item 1. 2 of the Movement Disorders Society&apos;s Unified Scale for Assessment of Parkinson`s disease; diagnosis of dementia according to the Movement Disorders Society diagnostic criteria; suffering from serious systemic conditions (infections, malignancies, chronic kidney or liver disease); pregnancy or lactation; history of hypersensitivity or allergic reaction to tetracyclines; absence of clinical dyskinetic movements at baseline assessment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-2svpc94	Efeito of a digital game on physical activity and diet in adolescents	Not yet recruiting	Intervention	2022-05-12	<NULL>	<NULL>	5392	Impact of a digital game on physical activity and eating habits in adolescents	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-03-21	Universidade Federal do Paraná	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-2svpc94	<NULL>	Volunteers healthy, with no health problems that prevent them from practicing physical activity; aged between 10 and 14 years old; enrolled in elementary school II (6th to 9th grade); have a minimum class attendance of 75%; have a Free and Informed Consent Form signed by parents or guardians before the beginning of the interventions; sign the Free and Informed Consent Form; have their own smartphone for the intervention.	Volunteers who withdraw from the research; do not adapt to the use of the exergame.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-4gwpvmr	Study of the implementation of integrative practices in a tertiary hospital in the city of São Paulo	Not yet recruiting	Intervention	2022-05-11	<NULL>	<NULL>	5389	Implementation of the Integrative Pediatrics Unit at the Children and Adolescents Institute (ICr) of the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo (HC-FMUSP)	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4gwpvmr	<NULL>	This implementation study will include one pediatric inpatient unit of medium and high complexity of the Instituto da Criança e do Adolescente, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo; with a multidisciplinary team; number of beds less than 20	Not being a pediatric inpatient unit of medium and high complexity at the Instituto da Criança e do Adolescente of the Hospital das Clínicas, Faculty of Medicine, University of São Paulo; not having a multidisciplinary team; with a number of beds over 20	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-7z8tzjf	Effects of Vestibular Stimulation through Positioning in Hammocks on the development of the premature baby compared to Motor Physiotherapy	Recruiting	Intervention	2022-05-10	<NULL>	<NULL>	5384	Effects of Vestibular Sensory Stimulation through Balanced Net Positioning in late Preterm Infants on neuromotor development compared to Conventional Therapy	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-03	Universidade Federal do Triangulo Mineiro	Universidade Federal do Triangulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-7z8tzjf	<NULL>	late preterm infants (born between 34 to 36 weeks and 6 days of gestational age); neonatal period; (newborns up to 29 days of life); hemodynamic stability; Apgar score at 1&apos; and 5&apos; above 7 points; minimum weight of 1100 grams; spontaneous breathing.	non-adaptation to treatment or that presents one or more of the following characteristics: cardiac or neurological diseases, osteopenia of prematurity and are receiving anticonvulsant, sedative or analgesic medication during the intervention or under phototherapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-8xd262t	Phototherapy for evaluation of the healing process in chronic wounds of patients with diabetes	Recruiting	Intervention	2022-05-10	<NULL>	<NULL>	5385	Photobiomodulation with Led as a new approach to the assessment of healing activity in chronic wounds of patients with diabetes	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2022-04-08	Universidade Federal dos Vales do jequitinhonha e Mucuri	Universidade Federal dos Vales do jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-8xd262t	<NULL>	Age equal to or greater than 18 years; of both sexes; diabetic participants with chronic wounds who accept to participate in the study	Patients with other types of lesions, such as erysipelas, lymphangitis, and chronic lymphedema; Pregnancy; Use of immunosuppressants or chronic corticosteroids; Patients undergoing cancer treatment; Wounds in an infectious process or wound bed with presence of coagulation necrosis covering more than 25% and lesion in the final stage of epithelialization; Photosensitivity or any adverse reactions to sunlight exposure	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-3jzp8gv	Evaluation of the Brazilian cardioprotective diet in hypertensive patients	Recruiting	Intervention	2022-05-10	<NULL>	<NULL>	5386	Evaluation of the effectiveness of Brazilian Cardioprotective Alimentation in reducing Blood Pressure and its associated risk factors in hypertensive users of BHU in Salvador/Bahia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-13	Universidade do Estado da Bahia	Universidade do Estado da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-3jzp8gv	<NULL>	Hypertensive men and women; with proven diagnosis; adults; older than 20 years; who have not been on a diet for 6 months.	Users with any neurocognitive condition or mental disorder (defined by their clinical history or clinical investigation); pregnant women; nursing mothers; users with liver failure; previous history of encephalopathy or anasarca; renal failure; with indication for dialysis; severe congestive heart failure; previous organ transplantation; gastroplasty; life expectancy of less than 6 months; wheelchair user and with difficulty receiving oral diet.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-2jbsf3j	Video exercise sessions for healthy people	Not yet recruiting	Intervention	2022-05-10	<NULL>	<NULL>	5387	Video containing physical exercise sessions to improve the physical activity level of healthy adults	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-10-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2jbsf3j	<NULL>	Adult individuals aged between 18 and 64 years will be included; with absence of comorbidities, physical mobility problems and/or changes in the cognitive level; not be performing physical activity at the moment; and have the ability to speak and understand the Portuguese language	Participants who did not perform the assessments of primary and secondary outcomes before and after the intervention and those who were not cleared by the physician to perform physical exercise will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-8cyqk93	Influence of low-level laser therapy on cheek fat removal on face measures, satisfaction with facial aesthetics and quality of life: a clinical trial	Recruiting	Intervention	2022-05-10	<NULL>	<NULL>	5388	Influence of low-level laser therapy on inflammatory parameters, satisfaction with facial aesthetics and quality of life in patients undergoing partial removal of the buccal extension of the cheek fat pad: a randomized, double-blind, placebo-controlled split-face clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Centro Universitário Christus - UNICHRISTUS	Centro Universitário Christus - UNICHRISTUS	https://ensaiosclinicos.gov.br/rg/RBR-8cyqk93	<NULL>	Healthy individuals (American Society of Anesthesiologists - ASA I) of both sexes; aged between 18-30 years; with the need to partially remove the buccal extension of the Bichat ball bilaterally	Smoking volunteers; pregnant or lactating women; signs of any preoperative inflammatory or infectious condition; systemic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:05
RBR-97jxbck	Music as Nursing Care to Decrease Distress in Women with Breast Cancer in Chemotherapy	Recruiting	Intervention	2022-05-06	<NULL>	<NULL>	5380	Music as Nursing Care to Reduce Distress in Women with Breast Cancer in Antineoplastic Chemotherapy: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Instituto do Câncer do Ceará	Universidade Estadual do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-97jxbck	<NULL>	Be 18 years of age or older; score 15 on the Glasgow scale; not being under psychiatric follow-up and / or reporting previous psychiatric disorders; have hearing acuity preserved by applying the whisper test (which will be explained in the research protocol item); be defined as a “case” of distress, namely: a score greater than or equal to 4 on the Distress Thermometer and a score greater than or equal to 15 on the Anxiety and Depression Scale.	Patients who do not follow the instructions given for the clinical trial will be excluded from the study, in order to avoid decreasing the internal validity of the study and bias in the research. As a criterion for discontinuity of the study, possible clinical complications will be adopted during the application of the intervention, such as episodes of emesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-99r7gvd	Effects of osteopathic intervention in transition duration from enteral nutrition to oral feeding in infants admitted to a pediatric ICU	Recruiting	Intervention	2022-05-06	<NULL>	<NULL>	5381	Effects of osteopathic intervention in transition duration from enteral nutrition to oral feeding in infants admitted to a pediatric ICU - Randomized and controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-11-11	Hospital de Clinica da UNICAMP	Hospital de Clinica da UNICAMP	https://ensaiosclinicos.gov.br/rg/RBR-99r7gvd	<NULL>	Infants (28 days to 2 years) admitted to the pediatric ICU of HC Unicamp, using enteral nutrition through a nasogastric or nasoenteral tube that presents a risk factor for dysphagia. Informed Consent Form (TCLE) signed	Genetic syndromes. Chronic neuropathies. Structural anomalies of the digestive tract. Postoperative of neurological, gastrointestinal, face and upper and lower airways surgeries.  Cancer patients. Previous osteopathic treatment. Transfer of the infant to another service	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-9whhh7w	Evaluation of the effectiveness of omega 3 supplementation in individuals with redistribuition of body fat related to the use of HIV medications. Relationship with cell integrity measure	Recruitment completed	Intervention	2022-05-06	<NULL>	<NULL>	5382	Evaluation of the effectiveness of fatty acid supplementation omega 3 in patients whith lipodystrophic syndrome secondary to antiretroviral therapy. Relationship whith phase angle	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2021-03-01	Núcleo de Medicina Tropical- Universidade Federal do Pará	Thalita Bandeira Dantas e Silva	https://ensaiosclinicos.gov.br/rg/RBR-9whhh7w	<NULL>	This study will include patients with HIV-associated lipodystrophic syndrome, adults, of both sexes, aged over 18 years, with a previous diagnosis of the disease provided by the team at Hospital Jean Bitar, who are undergoing outpatient follow-up and treatment with antiretroviral ( ART). It is necessary that the patient agrees to participate in the research and sign the Informed Consent Form (ANNEX A).	All individuals with SLHA who present a condition of vulnerability and / or associated disease that negatively interferes with the predicted values ​​of phase angle, such as severe obesity (BMI ≥ 40kg / m2), presentation of the picture will be excluded from the population covered by the inclusion criteria. edema, ascites, patients with neurological diseases that compromise the understanding of the study, in case of use of pacemaker or any metal prosthesis / orthosis, kidney disease, patients using diuretics, as well as pregnant or lactating women. Those who refuse to participate spontaneously in this research protocol will also not be included in the study, in addition to all those people who do not adequately prepare for the bioimpedance exam, as well as those who do not demonstrate adherence to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-102ydhjs	Homeopathy as an adjuvant treatment for patients with COVID-19 Associated Pneumonia	Data analysis completed	Intervention	2022-05-06	<NULL>	<NULL>	5383	Homeopathy as an adjuvant treatment for patients with COVID-19 - HU/UFSC	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2020-07-13	Universidade Federal de Santa Catarina	Hospital Universitário Polydoro Ernani de São Thiago	https://ensaiosclinicos.gov.br/rg/RBR-102ydhjs	<NULL>	Both genders; age between 20 and 70 years; positive test for SARS-CoV-2 by reverse transcription polymerase chain reaction or rapid antigen test; pneumonia, diagnosed according to clinical criteria, with or without imaging confirmation (plain radiographs, computed tomography angiography); Indication of hospital admission; no clinical condition that impairs verbal communication; homeopathy interview within 24 hours of admission.	Pregnancy, or women who had given birth up to 45 days earlier; hospital admission for palliative care; lower oxygen saturation 93 percent through an oxygen reservoir mask (criterion for admission to intensive care unit)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-4k44npd	Dance therapy benefits to older people	Recruiting	Intervention	2022-05-04	<NULL>	<NULL>	5377	Dance movement therapy contributions to the health and quality of life of elderly people at risk of functional decline	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-08	Universidade de Cruz Alta	Universidade regional do noroeste do estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4k44npd	<NULL>	Elderly people included in the Viver 60+ project (screening project for functional decline of users of UNIMED Planalto Centro in partnership with Unicruz). Being a resident of Cruz Alta. Show signs of functional decline. Have been submitted to the pre-test evaluations of the project.	Elderly people who do not accept to participate in the program and those who have medical contraindications or who do not participate in at least 25% of the proposed sessions within the three-month period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-3t3qwp7	Effect of Music in Pain Relief during the removal of the cannula inserted in the femoral artery after Cardiac Catheterization: a randomized clinical trial	Recruiting	Intervention	2022-05-04	<NULL>	<NULL>	5378	Efficacy of Music in Pain Relief during the femoral arterial introductor withdrawal after Cardiac Catheterism: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-25	Rodrigo Assis Neves Dantas	Rodrigo Assis Neves Dantas	https://ensaiosclinicos.gov.br/rg/RBR-3t3qwp7	<NULL>	Patients admitted to hemodynamics for cardiac catheterization with the need to remove the arterial introducer via the femoral route; elective procedures; age 18 years or older.	Not liking music; patients who have already undergone the aforementioned procedure; presence of chronic pain; previous analgesia; individuals with some neurological and/or cognitive problem that compromise the understanding and use of the scale at the appropriate time; hearing impaired individuals.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-7fv8m94	Treatment of Barrett&apos;s esophagus by Radiofrequency	Recruiting	Observational	2022-05-04	<NULL>	<NULL>	5379	Comparative study of radiofrequency ablation of Barrett’s esophagus with dysplasia in patients previously submitted or not to surgical treatment of gastroesophageal reflux disease	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7fv8m94	<NULL>	Barrett&apos;s esophagus with low-grade dysplasia without evident lesions; Barrett&apos;s esophagus with high-grade dysplasia without evident lesions; Barrett&apos;s esophagus remaining endoscopic post-treatment of visible low- and high-grade dysplastic lesions of dysplasia and / or intramucosal adenocarcinoma.	Having a severe systemic disease or psychiatric disorder; Having a pacemaker; Biopsies showing no BE-related intestinal metaplasia;Barrett&apos;s esophagus with areas showing no current or previous dysplasia; refusal to sign the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-9nd7py4	Effects of High Intensity Interval Training on Metabolism in Obesity.	Recruiting	Intervention	2022-05-02	<NULL>	<NULL>	5375	Redox State, Immunometabolism and Meta-inflammation in Obesity: Gene Expression and Responses to High-Intensity Interval Training.	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade da Região de Joinville	Hospital Regional Hans Dieter Schmidt	https://ensaiosclinicos.gov.br/rg/RBR-9nd7py4	<NULL>	Both genders; being assisted by the Public Health System (SUS); age between 20 and 55 years; deliver the signed Informed Consent; do not participate in any other regular physical exercise program; do not present untreated or poorly controlled clinical disorders that could interfere with the variables of the study, such as altered levels of the TSH and free T4 hormones, even when taking medication; do not present untreated or poorly controlled clinical disorders, such as arterial hypertension, heart disease, or any other disease that could offer risk to the participant when practicing high-intensity exercises.	Any clinical complication during the intervention that influences the variables analyzed in this study or makes it impossible for the participant to continue the intervention and/or the evaluations, including orthopedic alterations or pain disorders; frequency in the HIIT program lower than 70% or absence from any evaluation performed in the study; use of appetite-suppressant medications; presence of diabetes; being menopausal, according to medical criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-6jhtvfy	Use of Natalizumab in patients with Multiple Sclerosis	Data analysis completed	Observational	2022-05-02	<NULL>	<NULL>	8326	Impact of Natalizumab use in patients with Multiple Sclerosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-06-01	Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição da Universidade Federal de Mato Grosso do Sul	Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição da Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6jhtvfy	<NULL>	Patients diagnosed with Multiple Sclerosis, according to the 10th edition of the International Code of Diseases (ICD 10), classified as G35, diagnosed according to revised and adapted McDonalds criteria will be included in the research; of both sexes; aged over 18 years; who have been on natalizumab treatment for at least 3 months, presenting at least one Expanded Disability Status Scale (EDSS) assessment prior to the use of natalizumab and a subsequent assessment	Individuals with cognitive alterations that make it difficult to remember facts related to their disease and to understand the research will be excluded, as well as those who do not meet the inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:52
RBR-8qnmdpm	Pelvic muscle training associated with the use of pessaries in the treatment of pelvic organ fall: Randomized clinical trial	Not yet recruiting	Intervention	2022-04-28	<NULL>	<NULL>	5369	Pelvic floor muscle training associated with the use of pessaries in the treatment of pelvic organ prolapse: Randomized clinical trial	<NULL>	0, randomized-controlled, single-blind	0	<NULL>	<NULL>	<NULL>	2022-05-16	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8qnmdpm	<NULL>	Women with pelvic organ prolapse; staging equal to or greater than two; present intact vaginal mucosa and prolapsed region; are without signs and / or symptoms of urinary tract infection; without vaginal infections	Women whose insertion of the pessary was not successful; women with a modified Oxford score less than two	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-2x84bbn	Whole Body Vibration exercise in clinical, functional health and oxidative stress in women with fibromyalgia	Recruitment completed	Intervention	2022-04-28	<NULL>	<NULL>	5370	Whole Body Vibration Stimulus training on clinical, functional and Redox Status in women with Fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Federal dos Vales do Jequitinhonha e Mucuri	Universidade Federal dos Vales do Jequitinhonha e Mucuri	https://ensaiosclinicos.gov.br/rg/RBR-2x84bbn	<NULL>	Women aged 35 to 70 years; with confirmed diagnosis of fibromyalgia between 1 and 3 years; presence of sensitivity in at least 11 of the 18 specific pain points according to the American College of Rheumatology criteria	Women who present; any concomitant illness that may be exacerbated by physical activity; pregnancy; orthopedic limitations; inflammatory diseases; degenerative; joints; respiratory or cardiovascular diseases; who are under follow-up with a psychiatrist; who perform physical activity for the same twice a week; present any of the possible contraindications for the intervention of Whole Body Vibration (acute hernia; thrombosis; diabetes, epilepsy; metabolic or neuromuscular diseases; orthopedic injuries and prostheses); use immunosuppressive medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-4p29wg5	Effects of Osteopathy and Ankle Self-Mobilization on Athlete Ankle Range of Motion Gain	Not yet recruiting	Intervention	2022-04-28	<NULL>	<NULL>	5371	Effects of Osteopathic Manipulative Treatment versus Talocrural Automobilization on Ankle Mobility and Functionality in Athletes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-30	UDF - Centro Universitário do Distrito Federal	UDF - Centro Universitário do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-4p29wg5	<NULL>	Athletes who practice soccer, running, crossfit or any other modality that generates joint impact in the execution of their movements; practitioner of the modality with training frequency of at least three times a week; Age between 18 and 40 years; Possess reduced active range of motion (ROM) of ankle dorsiflexion (less than 20 degrees of ROM for dorsiflexion in one or both ankles), either in open kinetic chain (OCC) or chain closed kinetics (CCF)	Acute or chronic muscle, ligament, joint and/or tendon injuries; Use of lower limb prostheses; Congenital orthopedic and neurological injuries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-62yhd5k	Evaluation the effectiveness and additional treatment period of different wear times in at-home dental bleaching	Recruitment completed	Intervention	2022-04-28	<NULL>	<NULL>	5372	Analysis the effectiveness and additional treatment period of different wear times in at-home dental bleaching: a randomized clinical split-mouth trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Faculdade de Odontologia de Araçatuba	Empresa Ultradent	https://ensaiosclinicos.gov.br/rg/RBR-62yhd5k	<NULL>	Those included in the study must present absence of caries lesion, deficient and/or fractured restorations, periodontal diseases and dental element with spontaneous pain; healthy oral soft tissues and good systemic condition; who do not have a history of adverse reaction to peroxides and teeth with at least A2 of color scale (VITA).	Those under 18 years of age and over 30 years of age; patients with restorations on the buccal surface of central, lateral, canine and premolar incisors will be excluded; those with fixed orthodontic appliances or that contain resin residues on the buccal surface after their removal; pregnant or lactating women; smokers and those who routinely use alcohol; those who did not accept the research consent form; those who have already undergone bleaching treatment before and those with teeth that have tetracycline stains, fluorosis, pulped teeth.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-63gkbbq	Manual therapy in menopausal women suffering from insomnia	Recruiting	Intervention	2022-04-28	<NULL>	<NULL>	5373	Osteopathic Treatment in Insomnia in Menopausal Women: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-18	Escuela de Osteopatia de Madrid Brasil	Escuela de Osteopatia de Madrid Brasil	https://ensaiosclinicos.gov.br/rg/RBR-63gkbbq	<NULL>	The following will be included in the studies: Women with amenorrhea for more than 11 (eleven) months; PSQI (Pittsburgh Sleep Quality Index) score &gt; 5 (greater than five); Participants who voluntarily agree to participate in the study and sign the Free and Informed Consent Form (FICT) for a randomized clinical trial.	Women will be excluded from the study: With serious mental illnesses, such as depression (last three months), anxiety, schizophrenia, etc., or serious or unstable medical conditions; Secondary insomnia caused by systemic illnesses such as pain, fever, cough, recent surgery, sleep apnea, and external environmental disturbances; Taking sex steroid hormones (six months or more); Shift work; Consumption of alcoholic beverages daily; Use of prescription or over-the-counter treatments for symptoms (thirty days ago); Smoking history; Heart disease and/or hypertension; Use of drugs for weight loss, anxiety, depression, sleep induction, heart disease and hypertension.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-34wswsg	Evaluation of Photodynamic Therapy with LED in the treatment of Temporomandibular Disorders	Recruiting	Intervention	2022-04-28	<NULL>	<NULL>	5374	Assessment of Photodynamic Therapy with LED on pain, limitation of mandibular moviments and quality of life in patients with Temporomandibular Joint Dysfunction: a double-blind, randomized and controlled clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-16	Centro Universitário do Pará	Capellux	https://ensaiosclinicos.gov.br/rg/RBR-34wswsg	<NULL>	Patients diagnosed with temporomandibular disorders after application of a questionnaire based on the DC-TMD (Diagnostic Criteria for Temporomandibular Disorders) and clinically evaluated by a trained professional; Patients of both sexes; aged between 18 and 50 years; who present unilateral or bilateral pain on palpation in the temporomandibular joint; pain on palpation in the masseter, temporal, medial pterygoid and lateral pterygoid muscles will be included	Patients treated with orthodontics or orthopedics recently; Patients diagnosed with some degenerative disease of the temporomandibular joint; Patients diagnosed with systemic diseases such as fibromyalgia, rheumatoid arthritis, osteoarthritis or osteoarthrosis, osteoporosis and osteopenia; Using any drug with analgesic, sedative, muscle relaxant or anti-resorptive effects; Pregnancy; Photosensitivity history	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-4mxg57b	Study of multiprofessional treatment in patients with COVID-19	Recruiting	Intervention	2022-04-27	<NULL>	<NULL>	5363	The effect of multiprofissional program interventions in biopsychosocial parameters in people with Obesity after COVID-19	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Univesidade cesumar de Maringá	Instituto Cesumar de ciência, tecnologia e inovação.	https://ensaiosclinicos.gov.br/rg/RBR-4mxg57b	<NULL>	Confirmed patients with covid-19. both genders. aged 19-59 years	Debilitating neurological diseases. current use of corticosteroids. diagnosis of chronic diseases. pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-7s8qnjj	Effect of Botulinum Toxin Type A on neuromuscular adaptations in individuals with muscle stiffness after Stroke	Not yet recruiting	Intervention	2022-04-27	<NULL>	<NULL>	5364	Effect of Botulinum Toxin Type A on neuromuscular plasticity in individuals with spasticity post-Stroke	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2022-05-09	Universidade Federal do Rio Grande do Sul -UFRGS	Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul- PUCRS	https://ensaiosclinicos.gov.br/rg/RBR-7s8qnjj	<NULL>	individuals over 18 years of age; of both sexes; who have suffered a stroke; incident time greater than 12 months; ability to walk with or without crutches/canes; presence of spasticity in the ankle plantarflexor muscles	Individuals in rehabilitation or any treatment of a kinetic-functional nature; individuals who have already applied botulinum toxin for less than six months; history of surgical procedure or use of orthopedic prosthesis; presence of neurological disease or dementia; cognitive alteration that prevents understanding of the research; presence of joint or musculoskeletal injury of an inflammatory nature	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-8d82mtz	Immediate result of manual treatment of lung symptoms in people suffering from COVID-19 - Controlled randomized clinical trial	Recruiting	Intervention	2022-04-27	<NULL>	<NULL>	5365	Immediate effect of osteopatic manipulative treatment on pulmonary sequel in patients post COVID 19 - Controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-10	Ana Paula Cochar	Escola de Osteopatia de Madrid - Brasil Ltda. (EOM - Brasil)	https://ensaiosclinicos.gov.br/rg/RBR-8d82mtz	<NULL>	Will be selected for this study, individuals between 18 and 60 years, both sexes, who had a positive diagnosis for COVID-19, confirmed by the RT-PCR test or who were diagnosed using clinical criteria associated with radiological image, computed tomography, D-dimer , presenting a picture compatible with COVID-19, hemodynamic stability and who presented a decrease in oxygen saturation. In addition, patients who did not progress to mechanical ventilatory support and who, after the active viral period, evolved with sequelae caused by the disease will be considered.	Participants will be excluded from the study if they present lowered level of consciousness or who are unable to obey simple commands, acute decline in neurological status; hypotension (MAP less 60 mmHg) or hypertension (MAP up to 120 mmHg); tetany; continuous renal replacement therapy; Body Mass Index - BMI up to 30 kg/m2; previous thoracic surgery; chest instability; presence of chest tube; with complications from other serious underlying diseases, such as decompensated diabetes, obstructive and restrictive pulmonary disease, coronary heart disease, stroke with sequelae, fractures with sequelae, cancer, osteoporosis, immunodeficiency, fever, use of illicit drugs, congenital malformations, deformities, rejection of the treatment and any clinical alteration that makes the handling and execution of the technique unfeasible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-9bsf32r	Comparative clinical trial between intra-articular corticosteroid infiltration or microfragmented adipose tissue in knee osteoarthritis	Recruiting	Intervention	2022-04-27	<NULL>	<NULL>	5367	Randomized, triple-blind, controlled study to evaluate the efficacy of intra-articular infiltration of microfragmented aspirate of autologous adipose tissue compared to intra-articular infiltration of corticosteroids in the treatment of knee osteoarthritis	<NULL>	3, randomized-controlled, triple-blind	3	<NULL>	<NULL>	<NULL>	2021-11-03	Instituto de Ortopedia e Traumatologia de Universidade de São Paulo	Geistlich Pharma do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-9bsf32r	<NULL>	Knee Osteoarthritis.Absence of local or systemic infection.Absence of arthritis of rheumatologic origin.Clinical deformity (varus/valgus/flexo/recurvate)or radiographic &lt; 10 degrees.Patient able to understand the nature of the study.Informed consent filled in by the patient.Absence of any intra-articular procedure less than 3 months before the start of the study.Absence of clinical contraindications to the study.Absence of congenital or acquired disease generating large deformity in the knee that could interfere with the application of mesenchymal cells or interpretation of results.Absence of neoplasm under treatment.Non-pregnant patient.Absence of grade 3 obesity with BMI &gt;40 (kg/height in m2)	Loss to follow-up.Presence of serious/debilitating clinical condition.Presence of new orthopedic injuries relevant during the study period (severe joint trauma to the knee.fractures of the lower limb or new ligament injuries).death	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-2rkhnzt	Impact of Mindful Eating on the eating behavior of overweight and obese individuals in an academic community	Recruiting	Intervention	2022-04-27	<NULL>	<NULL>	5368	Impact of a nutritional intervention based on Mindful Eating on the eating behavior of overweight and obese individuals in an academic community	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-30	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2rkhnzt	<NULL>	Volunteers over 18 years old; with a body mass index greater than or equal to 25 kg/m²; with access to the internet and digital platforms Moodle and Google Meet; with availability to participate in 8 virtual meetings	Volunteers using pharmacotherapy for obesity; gestation; lactation; cognitive conditions; neurological or psychiatric disorders that prevent participation in the study; decompensated thyroid disorders; who have had bariatric surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-47jxgzv	Effect of the use of guarana powder (Paullinia cupana) on the modulation of blood markers and mood in young adults	Terminated	Intervention	2022-04-27	<NULL>	<NULL>	6323	Effect of the use of guarana powder (Paullinia cupana) on the modulation of brain-derived neurotrophic factor and depressive symptoms in young adults	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-16	Faculdade de Saúde Pública da Universidade de São Paulo - FSP/USP	Faculdade de Saúde Pública da Universidade de São Paulo - FSP/USP	https://ensaiosclinicos.gov.br/rg/RBR-47jxgzv	<NULL>	Young adult individuals (18 to 40 years old); Body mass index (between 18.5 and 29.99 kg/m2); Be willing to adhere to the study protocol; Be willing to sign the informed consent form (ICF)	Age under 18 and over 40; BMI greater than 29.99 Kg / m²;Having depression, hypertension and / or insomnia; Make use of medication prescribed to control anxiety, depression or other psychiatric disorder; Be a regular consumer of guarana, consumption of coffee, teas or energy drinks more tha 3 doses/day, as adopted in the study by Dood et al. (2015); Being pregnant or nursing; Be participating in another study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-6vq3hc4	Assessment of effect of different concentrations of Sodium Hypochlorite on Postoperative Pain and Success Rate of Root Canal Treatment of Necrotic Mandibular Molars	Recruitment completed	Intervention	2022-04-27	<NULL>	<NULL>	6328	Effect of different concentrations of Sodium Hypochlorite on Postoperative Pain and Success Rate of Endodontic Treatment of Necrotic Mandibular Molars	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-6vq3hc4	<NULL>	Patients: healthy (ASA I classification); over 18 years of age; asymptomatic; indication for endodontic treatment of manbidular molar (first or second). Dental element: pulp necrosis; negative response to the cold pulp sensitivity test; radiographic image compatible with a radiolucent periapical lesion of origin endodontic.	Patients: who have some type of comorbidity; smokers; pregnant; under 18 years old; who have used medication that may alter the perception pain, such as analgesics or anti-inflammatory, at least 48 hours before the procedure, and use of antibiotics 30 days before treatment. Dental element: prior manipulation of root canals; associated periodontal lesion; interradicular furcation lesion; mobility above grade I; presence of fistula, abscess or edema; calcified or internally resorbed root canals; roots with a degree of curvature greater than 45 degrees; incomplete root formation; C shaped internal anatomical conformation; widely destroyed crown that makes absolute isolation and/or restoration impossible immediate finish with composite resin.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:39
RBR-9nv67bj	Tai Chi Chuan effect on the well-being of people with diabetes and high blood pressure	Recruitment completed	Intervention	2022-04-26	<NULL>	<NULL>	6175	Effect of Tai Chi Chuan practice on stress, anxiety, and self-perception of happiness	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Faculdade de Odontologia de Piracicaba - Universidade de Campinas (FOP-UNICAMP)	Faculdade de Odontologia de Piracicaba - Universidade de Campinas (FOP-UNICAMP)	https://ensaiosclinicos.gov.br/rg/RBR-9nv67bj	<NULL>	Individuals who practice physical exercises such as Tai Chi, Yoga and Bodybuilding in sports academies and individuals who do not practice any physical activity; individuals diagnosed with arterial hypertension (greater or equal to systolic pressure: 140 to159 mmHg, diastolic pressure: 90 to 99 mmHg) and diabetes mellitus (fasting glucose more or iqual to 200) from a Health Unit who practice or not physical activity.	Individuals with systemic alterations and/or special needs that make it impossible to fill out the questionnaires; users who do not understand the objective of the study or do not accept the methodology; individuals who practice Tai Chi.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:33
RBR-4473k7y	Evaluation of the expression of inflammatory cytokines in the gingival crevicular fluid of patients with Covid-19.	Recruitment completed	Intervention	2022-04-25	<NULL>	<NULL>	5359	Evaluation of the expression of inflammatory cytokines in the gingival crevicular fluid of patients with Covid-19. Pilot Study	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2020-06-22	Universidade Estadual do Oeste do Paraná	Hospital Universitário do Oeste do Paraná - HUOP	https://ensaiosclinicos.gov.br/rg/RBR-4473k7y	<NULL>	Individuals, aged 18 to 70 years, with respiratory failure treated at the COVID 19 Ward and at the ICU of the University Hospital of West Paraná HUOP/UNIOESTE, in Cascavel/Pr	Wearers of complete upper and lower dentures simultaneously; Smokers; Pregnant women; Ethyls; Users of any type of drug; who are taking antidepressants, anti-inflammatory drugs, anticonvulsants, calcium blockers, or any other drug that may interfere with the results of this study; Under 18s	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-4g2w8sc	Effects of Water-Based Exercises and Nutritional Guidance on Body Composition and Physical Performance of Older Women with Knee Osteoarthritis	Terminated	Intervention	2022-04-25	<NULL>	<NULL>	5360	Effects of Water-Based Exercises and Nutritional Guidance on Body Composition and Functionality of Older Women with Knee Osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-03-02	Centro Universitário Unidombosco	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-4g2w8sc	<NULL>	Women at least 65 years old diagnosed with uni ou bilateral knee osteoarhritis grade I - IV  (KELLGREN; LAWRENCE, 1957). Were able to walk independently without orthosis and/or auxiliary devices.	The participants with (a) prostheses in any lower limb joint; lower limb surgery in the last 12 months; (b) insulin-dependent; (c) or restrictive conditions to physical activities were excluded. In addition, participants engaged in any other regular training programs in the six months that preceded the study were not included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-33t6s52	The effect of Transcranial Direct Current Stimulation in pain control in patients with Rheumatoid Arthritis	Not yet recruiting	Intervention	2022-04-25	<NULL>	<NULL>	5361	Transcranial Direct Current Stimulation in pain control in patients with Rheumatoid Arthritis: a randomized, placebo-controlled, double-blind, phase II clinical trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Federal do Amazonas	Fundação Hospital Adriano Jorge	https://ensaiosclinicos.gov.br/rg/RBR-33t6s52	<NULL>	Adult volunteers (higher than 18 years) diagnosed with Rheumatoid Arthritis; both genders; with chronic pain longer than 12 weeks or 3 months; with a pain level greater than 7 by the visual analog scale of Pain and who are using synthetic disease-modifying drugs	Volunteers who are using biological disease-modifying drugs; who have neuropsychiatric diseases; who have a history of illicit drug use and abuse; who have neurological, cognitive, or motor deficits; who underwent neurosurgical interventions (craniotomy); who have a clinical diagnosis of severe depression with more than 30 points according to the Beck Depression Inventory tool; who have a history of seizures and/or epilepsy; who are using high doses of opioids (more than 30 mg of Oxycodone, Hydrocodone or 7.5 mg of Hydromorphone or equivalent drug); pregnant women; who have metallic implants in the cranial and/or facial region; who use a pacemaker; with a history of skin diseases; who have other autoimmune diseases not related to Rheumatoid Arthritis; who have cancer diseases; who have disease in the decompensated phase (ischemic heart disease, kidney and/or liver diseases)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-8j2c99x	Evaluation of the efficiency of walant anesthesia for carpal tunnel syndrome surgery in the outpatient clinic	Recruiting	Intervention	2022-04-20	<NULL>	<NULL>	5354	Evaluation of the anesthetic efficacy level of the WALANT for carpal tunnel syndrome surgery in an outpatient setting	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Kássio Rodrigues De Macêdo	Kássio Rodrigues De Macêdo	https://ensaiosclinicos.gov.br/rg/RBR-8j2c99x	<NULL>	Patients diagnosed with Carpal Tunnel Syndrome, with surgical indication, both sexes, age between 18 to 90 years	Patients which have already underwent any surgical for carpal tunnel syndrome procedure or patients with fibromyalgia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-2wcyvss	Plasticity in corticomotor pathways following a tooth-clenching task and masseter sensitization is impaired in bruxers compared to matched control individuals	Data analysis completed	Intervention	2022-04-20	<NULL>	<NULL>	5355	Could sensorimotor cortical excitability be modulated by simulated jaw function activity and hyperalgesia induced by intramuscular NGF administration	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-16	Aarhus University	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-2wcyvss	<NULL>	The volunteers participating in the study were in good general health; of both gender, aged less than 18 years; and with no orofacial pain complaints in the last 30 days or chronic pain disorders.	Presence of dental or medical illness; regular intake of medication such as antidepressants; anticonvulsants; or nonsteroidal anti‐inflammatories; any diagnosis of psychiatric or personality disorders; and the presence of contraindications to transcranial magnetic stimulation (i.e., metal implants in the head; implanted electronic devices; history of epilepsy and if they were pregnant) were defined as exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-3npxs32	Evaluation of postoperative pain in heart surgery: Comparison between Erector spinae plane block and morphine	Recruitment completed	Intervention	2022-04-20	<NULL>	<NULL>	5356	Postoperative analgesia in cardiac surgery: Comparison between Erector spinae plane block and intravenous morphine	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Hospital Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)	Hospital Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)	https://ensaiosclinicos.gov.br/rg/RBR-3npxs32	<NULL>	Patients undergoing elective open heart surgery; age between 18 and 70 years; American Society of Anesthesiologists (ASA) classification classes I to III; Cardiac Anesthesia Risk Evaluation (CARE) score 1 and 2; and who sign the consent term.	Patients with liver failure; ropivacaine and dipyrone allergy; Body Mass Index (BMI) greater than 40 kg/m²; left ventricular ejection fraction less than 40 percent; emergency surgery; hemodynamic instability; chronic use of opioids (use of opioids for more than 3 months or daily dose of morphine greater than 5mg/day for 1 month); post-operative reintubation; need for surgical re-approach in the postoperative period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-6vbgvqh	Treating Shoulder Pain: Corticosteroid Injection vs. Phenol Injection	Recruiting	Intervention	2022-04-20	<NULL>	<NULL>	5357	Acromioclavicular joint pain: Intra-articular Corticosteroid Injection versus Neurolysis of the acromial branches of the suprascapular and lateral pectoral nerves with 5% Phenol	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Gilson Carone Neto	Hospital do Servidor Público Estadual de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-6vbgvqh	<NULL>	Male and female patients; over 18 years old; with pain in the acromioclavicular joint (for more than a month); with moderate or severe chronic joint pain (VAS equal to or greater than 4).	Patients with contraindications to the procedure: blood dyscrasia; refusal of the procedure; infection at the puncture site; patients with any other shoulder dysfunction that may confound the diagnosis such as advanced osteoarthritis of the glenohumeral joint, or adhesive capsulitis; patients with cognitive impairment or psychiatric disorder; allergic to lidocaine, methylprednisolone and phenol; pregnant women; patients with complete loss of joint space on ultrasound examination.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-7hfd5rc	Clinical Trial: Accelerated Recovery Protocol in Patients Undergoing Bariatric Surgery	Recruiting	Intervention	2022-04-20	<NULL>	<NULL>	5358	Clinical Trial: Accelerated Recovery Protocol in Patients Undergoing Bariatric Surgery. Randomized Comparative Study Between Usual Acceleration Protocols and the One Currently Used in the Institution (SAMSURP)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Casa de Saúde Santa Marcelina	Casa de Saúde Santa Marcelina	https://ensaiosclinicos.gov.br/rg/RBR-7hfd5rc	<NULL>	Patients aged between 18 and 60 years; able to read, understand and sign the consent form; undergoing the first procedure for the treatment of obesity	patients with a BMI above 60 kg/m2; patients with chronic pain with continuous use of medications for pain control, such as fibromyalgia and non-eventual low back pain; patients with heart and coronary diseases; ventricular ejection fraction less than 50%; anticoagulation with warfarin; patients with chronic kidney disease on dialysis; patients with mobility and ambulation difficulties; prolonged surgical time (greater than 3 hours) or need for conversion to open surgery; patients referred to the intensive care unit (ICU) after the procedure; need for drainage of the abdominal cavity; latex allergy; allergy to any of the medications used in the protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-2m7qkjy	Effectiveness of a care plan for cancer survivors	Recruiting	Intervention	2022-04-19	<NULL>	<NULL>	5350	Efficacy of the Treatment Summary and Survivorship Care Plan (TSSCP-S): experimental study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal de São Paulo	Fundação Antônio Prudente	https://ensaiosclinicos.gov.br/rg/RBR-2m7qkjy	<NULL>	Age over 18; breast cancer patients; women; tumor at all stages; submitted to clinical therapies with chemotherapy, surgical and radiotherapy; who have completed the treatment (except endocrine therapy)	Patients who have not undergone surgical procedures for the treatment of breast cancer; patients with psychiatric disorders attested to in medical records, which makes educational practice unfeasible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-4d93q84	Effect of active storytelling methodology on learning about the Unified Health System	Not yet recruiting	Intervention	2022-04-19	<NULL>	<NULL>	5351	Effect of storytelling on learning about the history and institutionalization of the Unified Health System: a randomized controlled study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-4d93q84	<NULL>	students regularly enrolled in the 2nd period of the course; older than 18 years.	students expected to leave for the next 15 days; students who have already participated in the previous assessment of the instrument (in any of the previous stages of the study); not completing the data collection instrument completely; non-participation in the second application of the post-test that will occur on the 15th day after the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-955md27	Use of nutritional suplement in patients with Inflammatory Bowel Disease	Recruiting	Intervention	2022-04-19	<NULL>	<NULL>	5352	Use of Modulen® in patients with Inflammatory Bowel Disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-12-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-955md27	<NULL>	Patients diagnosed with Crohn&apos;s Disease or Ulcerative Colitis; diagnosis of Inflammatory Bowel Disease based on clinical, endoscopic, histological or imaging criteria; patients with evidence of clinical or endoscopic activity of the disease AND OR; patients at nutritional risk who fall into one of the following categories: loss of 5% of body weight within 30 days; AND OR 10% loss of body weight within 3 months; AND OR presence of body mass index less than or equal to 18.5 kg/m2	Patients with chronic illnesses such as: Human immunodeficiency virus, Diabetes Mellitus, malignant neoplasms, heart, liver and or renal failure, tuberculosis or disabling mental illnesses; patients with undetermined colitis; use of another nutritional supplement concomitant with Modulen	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-7cdwqzk	Forrotherapy: Effect of a procedure adapted from dance training on the conditions and quality of life of elderly people in the community	Not yet recruiting	Intervention	2022-04-19	<NULL>	<NULL>	5353	Forrotherapy: Effect of a protocol adapted from a functional training through dance on the quality of life and the physical-functional aspects of the elderly in the community: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-18	Centro Universitário CESMAC (Centro de Estudos Superiores de Maceió)	Centro Universitário CESMAC (Centro de Estudos Superiores de Maceió)	https://ensaiosclinicos.gov.br/rg/RBR-7cdwqzk	<NULL>	Elderly; both sexes; age equal to or greater than 60 years; preserved cognition; preserved mobility capacity.	Elderly people with paraplegia; totally dependent on walking aids; has dementia and severe attention deficit that makes it impossible to understand to respond to a simple verbal command. any orthopedic, rheumatologic or neurological alteration that makes independent walking impossible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-77w952r	Reiki in skin lesions and the assessment through the camera that captures the heat	Recruiting	Intervention	2022-04-18	<NULL>	<NULL>	5348	Reiki application in skin injuries / burns and thermography as evaluation method: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-77w952r	<NULL>	Adults, over 18 years of age, regardless of gender and education level and who present a clinical picture of skin/burn injuries	People with mental disorders; with local or systemic infections, with cellulitis in nearby areas; people who have undergone grafts or procedures that require long-term dressings, for example, dermal matrix grafting; people who have tattoos at the burn site, since metallic compounds in the dye can alter thermography images, and who have some type of device (near the evaluated site) that alters the skin temperature capture	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-6sm7n2w	The additional effect of electrotherapy in patients with shoulder tendinitis	Not yet recruiting	Intervention	2022-04-18	<NULL>	<NULL>	5349	The Additional Effect of Percutaneous Microelectrolysis in patients with rotator cuff Tendinopathy : a controlled randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-10	Geraldo Carvalho Magalhães	Hospital Universitário Alcides Carneiro	https://ensaiosclinicos.gov.br/rg/RBR-6sm7n2w	<NULL>	Men and women aged or older than 18 years; complaint of persistent pain in one or both shoulders for the past 3 months; clinical and imaging diagnosis of tendinopathy of any of the rotator cuff muscles	People with absolute or relative contraindication to MEP ( Percutaneous Microelectrolysis); diagnosis of rheumatologic, systemic or neurodegenerative diseases causing shoulder pain such as rheumatoid arthritis, sickle anemia or stroke hemiparesis; shoulder surgery history; history of corticosteroid infiltration treatment performed within the last 2 months; having other pathological conditions of a traumatic-orthopedic nature such as adhesive capsulitis, traumatic lesions of the labrum and fractures in the shoulder complex	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-4dct89b	Clinical Study of Bone Grafting in Dentistry	Recruiting	Intervention	2022-04-18	<NULL>	<NULL>	8051	Randomized Prospective Longitudinal Study of Calcium Phosphate Biphasic Graft	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Santa Catarina	Dentscare - LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4dct89b	<NULL>	Patients who have indications for bone grafting in maxillary sinus lift, socket filling after tooth extraction and filling the gap after implantation immediately after tooth extraction, compatible with indications for the use of bone graft biomaterials; patients over 12 years old; both genders	Patients under 12 years old; patients with infected areas and acute inflammatory processes; Pregnant or breastfeeding patients; patients with endocrine diseases or uncompensated chronic diseases such as diabetes, autoimmune dysfunction, therapy; or using drugs that compromise the healing response of bone tissue como prolonged therapy with corticosteroids, chemotherapy, bisphosphonates	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:42
RBR-6wy32ts	Influence of smoking and its degree of dependence on quality of life and oral health	Recruitment completed	Observational	2022-04-14	<NULL>	<NULL>	5344	Influence of smoking on oral health related to quality of life, associated with the degree of dependence	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-04-10	Universidade Federal Fluminense	Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-6wy32ts	<NULL>	Smoking and non smoking volunteers; both genders; 18 years of age or older; dental elements with clinical and radiographic diagnosis of Chronic Apical Periodontitis with indication for extraction	Teeth diagnosed with root fracture; previous endodontic treatment; and endo periodontal injury; individuals with systemic diseases; under the age of 18; users of anti-inflammatory and/or antibiotics in the last 3 months; drug users	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-7df547h	Comparison of the accuracy of the virtual result obtained by the Treatment with the Tooth Aligner of the company Invisalign® with the actual result achieved	Recruitment completed	Observational	2022-04-14	<NULL>	<NULL>	5345	Comparison of the accuracy of the result generated by Clincheck® with the actual result in the Invisalign ® through two treatment protocols	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-20	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7df547h	<NULL>	Healthy volunteers; of both genders; aged between 18 and 45 years; patients with poor dental position type Class I; with all permanent teeth in the mouth; without caries; or gum problems; who were treated without tooth extraction; employees; treated exclusively with the orthodontic aligner manufactured by invisaligncom®the G8 protocols; and prior to g8; during the years 2019 to 2022	Volunteers with cognitive disorders; with craniofacial anomalies; syndromes; patients with diabetes; patients with skeletal problems in the maxilla; and mandible; who received restorations in the teeth; during treatment with the orthodontic aligner manufactured by invisalign®	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-2vcncpm	Applicability of a sedation adjustment scale as well as orotracheal tube removal in pediatric patients: a randomized clinical trial	Recruiting	Intervention	2022-04-14	<NULL>	<NULL>	5346	Applicability of the comfort-behavior scale as predictor of weaning in pediatric patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Universidade Federal de Alfenas - UNIFAL MG	Hospital Universitário Alzira Velano	https://ensaiosclinicos.gov.br/rg/RBR-2vcncpm	<NULL>	Admitted to the pediatric intensive care uni; use of invasive mechanical ventilation; both genders; sedation use continues until extubation	Use of neuromuscular blockers; tracheostomy; service transfer; death; parents do not accept the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-97vy9n7	The effects of Home Rehabilitation compared to Face-to-face Rehabilitation in people with Peripheral Arterial Disease	Not yet recruiting	Intervention	2022-04-14	<NULL>	<NULL>	5813	Effectiveness of Home-based Rehabilitation compared to Face-to-face Rehabilitation in individuals with Peripheral Arterial Disease: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-01	Universidade Federal de Minas Gerais	Hospital das Clínicas da Universidade Federal de Minas Gerais  (HC-UFMG)	https://ensaiosclinicos.gov.br/rg/RBR-97vy9n7	<NULL>	Individuals over 18 years of age and with a diagnosis of peripheral arterial disease confirmed by the service; who have an ankle-brachial index at rest below 0.90; complain of intermittent claudication; no pain at rest; clinical stability no decompensation or hospitalization in the last three months; and who have access to a telephone	Will not be eligible subjects whose gait is limited by a condition other than peripheral arterial disease  (such as orthopedic; neurological or respiratory problems); who have any medical condition in which exercise is contraindicated (e.g. sepsis; critical limb ischemia; unstable angina; severe heart failure; active malignancy); and/or those who, in the concomitant presence of coronary artery disease are considered to be at high risk for moderate-intensity physical exercise; and/or have cognitive impairment assessed using the Mini-State Examination Mental in individuals aged equal or older to 60 years through the cut-off point of 13 for illiterates, 18 for low and medium schooling and 26 for high schooling; and/or are unable to understand and perform the procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:20
RBR-25nsk2n	Evaluation of Osteopathic Manipulative Treatment in the Chronic Pain and Stiffness of Chikungunya Fever	Recruiting	Intervention	2022-04-13	<NULL>	<NULL>	5342	Evaluation of Osteopathic Manipulative Treatment in the chronic musculoskeletal manifestations of Chikungunya Fever: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-30	Universidade Federal de Pernambuco	Empresa Brasileira de Serviços Hospitalares	https://ensaiosclinicos.gov.br/rg/RBR-25nsk2n	<NULL>	Age greater than or equal to 18 years; Diagnosis of Chikungunya Fever with positive serology chikungunya; Being in the chronic phase of the disease; Symptoms of pain and stiffness in upper limbs; Consent to participate in the study and be able to sign the consent form;	Patients with inflammatory joint diseases, prior to chikungunia infection; Diagnosis of diseases that compromise the functionality of the upper limbs; Presence of other chronic infectious diseases or neoplasms; Patients who had cognitive, auditory or visual deficits that prevented the application of assessment instruments; Patients who were undergoing physiotherapeutic treatment or had performed it in the last 2 months; Patients who were performing regular physical activity;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-4pn5whh	Homeopathic Treatment of Positive Covid-19 Symptomatic Patients	Other	Intervention	2022-04-13	<NULL>	<NULL>	5343	Evaluation of Homeopathic Treatment of Positive Covid-19 Symptomatic Patients in Relation to Physical and Mental Symptoms: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Faculdade de Medicina - Universidade do Estado de São Paulo (Unesp) - Campus Botucatu	Faculdade de Medicina - Universidade do Estado de São Paulo (Unesp) - Campus Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-4pn5whh	<NULL>	"Patients of both sexes; Present respiratory disease, with at least 3 (three) of the following symptoms: fever, chills, fatigue, myalgia, anorexia, sore throat, cough, expectoration, dyspnea, chest pain, headache, nasal congestion, conjunctival congestion, coryza , anosmia or hyposmia, dysgeusia, abdominal pain, diarrhea, rash; Present physical symptoms related to Covid-19 infection at the time of the first homeopathic consultation (symptomatic patients); Present a positive laboratory test (RT-PCR or serological) confirmed for COVID-19; Be ≥ 18 years of age; Not having the following comorbidities:
 severe heart disease (chronic or congenital), poorly controlled heart failure, poorly controlled COPD and asthma, cystic fibrosis with recurrent infections, chronic kidney disease at an advanced stage or undergoing dialysis, immunosuppressed, solid organ and bone marrow transplants; Sign the Free and Informed Consent Term (ICF) authorizing your participation in the research"	Individuals who no longer wish to participate in the clinical follow-up performed by the physician; Patients who fail to follow the therapeutic guidelines for the use of homeopathic medication as recommended (misuse, discontinuation of use); Asymptomatic patients for Covid-19, even with positive serological test or RT-PCR.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-3xnqxs8	Blood pressure response to aerobic training in hypertension	Recruitment completed	Intervention	2022-04-12	<NULL>	<NULL>	5338	Interindividual responsiveness of blood pressure to the increase in the volume, intensity and duration of aerobic training in hypertensive patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-06	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-3xnqxs8	<NULL>	Inclusion: Female participants; postmenopausal; systolic blood pressure and diastolic blood pressure lower than 160 and 100 mmHg.	Exclusion: active women; cardiovascular disease besides hypertension; limiting osteoarticular diseases; use of medications that directly affect the heart rate (i.e., beta-blockers); obesity stage 2 or greater; insulin-dependent diabetes mellitus; the presence of any cardiovascular alteration at resting or exercise electrocardiogram.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-64d65rm	Vacuum treatment associated with laser in patients with tinnitus	Recruiting	Intervention	2022-04-12	<NULL>	<NULL>	5339	Clinical treatment with vacuotherapy associated with low power laser in patients with tininitus	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-29	Universidade de São Paulo	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-64d65rm	<NULL>	Will be selected 40 volunteers (female or male), aged between 18 and 60 years with tinnitus complaint.	Patients under 18 years old and over 60 years old will be excluded. Patients with diabetes and uncontrolled cardiovascular problems will also be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-2z27nc9	Clinical study to evaluate the perceived safety and efficacy, under normal conditions of use, of the unflavored denture fixative cream product by evaluating the acceptability in the oral mucosa	Not yet recruiting	Observational	2022-04-12	<NULL>	<NULL>	5340	A clinical trial to evaluate the safety of the investigational product denture fixing cream without flavor , evaluating the acceptability in the oral mucosa and perceived efficacy under normal conditions of use	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-04-25	Kosmoscience Ciência e Tecnologia Cosmética Limitada	Cimed Industria Sociedade Anônima	https://ensaiosclinicos.gov.br/rg/RBR-2z27nc9	<NULL>	Age range between 18 and 60 years. Female and male. Phototype (Fitzpatrick): I to VI. Being a user of removable dental prostheses (dentures). Be a user of products of the same category. Agree on procedures and requirements during study use: study time (after 21 days) laboratory to perform investigational product home study procedures, change the product study diary, do not change the study product study diary. Agree to perform facial aesthetic dermatological treatments until the end of the study (21 days), such as: peelings, laser, fillers, use of any unusual suitable products	Pregnant or lactating women. Participant who belongs to the risk group for COVID-19, that is, with cardiovascular, renal and chronic respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group. Presence of dermatoses, active skin lesions (local and/or disseminated) or irritation in the mouth region (internal or external). Expected vaccination during the study or up to 3 weeks before the study. History of oral pathologies. Use of non-steroidal anti-inflammatory drugs, corticosteroids, antihistamines, photosensitizers or immunosuppressants up to 2 weeks before the study. Be participating in another study in the same application region. History of non-adherence or unwillingness to adhere to the study protocol. Being undergoing dental treatment. Not taking vitamin A or derivatives. Any condition that, in the opinion of the researcher, could compromise the study. (To describe)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-8f8yk8h	Effects of telepractice in Speech and Language Pathology on orofacial myofascial pain	Recruiting	Intervention	2022-04-12	<NULL>	<NULL>	5341	Effects of telecare focusing on chewing and swallowing functions on orofacial myofascial pain	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-17	Universidade Federal de Minas Gerais - UFMG	Pontifícia Universidade Católica de Minas Gerais - PUC Minas	https://ensaiosclinicos.gov.br/rg/RBR-8f8yk8h	<NULL>	Diagnosis of orofacial myofascial pain with spreading or referred according to CD-TMD (Diagnostic Criteria for Temporomandibular Disorders); age between 18 and 30 years; pain intensity higher then 4 by the numerical visual scale for at least 3 months prior to recruitment, having access to internet and the platform that will be used for teleterapy, signing the free and informed consent form (ICF).	Gestation; absence of central and lateral incisor teeth; presence of: dental pain, periodontal changes, previous or current tumor or major trauma in the head and neck region, edentulism, use of complete dentures and current orthodontics; diagnosis of fibromyalgia; presence of arthralgia, current myofunctional treatment or any other type of treatment for temporomandibular disorders; treatment for sleep disorders; continuous use of non-steroidal anti-inflammatory drugs, analgesics, antidepressants or central myorelaxant drugs; use of bronchodilators and vasoactive medications; presence of fever, allergic rhinitis, flu and/or cold symptoms; presence of neurological or cognitive impairments; use of a bandage on the skin and/or other factors that prevent its exposure to a balanced temperature environment at the time of data collection; performing physical exercises, acupuncture, massages, electrical stimulation, having attended saunas or being exposed to the sun for a long time on the day of the evaluation; not agreeing to participate in the research and refusing to sign the informed consent, as well as not carrying out the activities requested at the time of evaluation and therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-8wytcqf	Classical Ballet Exercises together with the traditional treatment of Urinal Dysfunction to improve the child&apos;s posture: a case report	Recruitment completed	Intervention	2022-04-11	<NULL>	<NULL>	5335	Additional Classical Ballet exercise protocol to urogynecological treatment to improve body posture and voiding dysfunction in a child: a case report	<NULL>	1, single-arm-study, open	1	<NULL>	<NULL>	<NULL>	2021-10-17	Universidade Santa Cecília	Universidade Santa Cecília	https://ensaiosclinicos.gov.br/rg/RBR-8wytcqf	<NULL>	Being female; be 6 years old or older; enjoying dances in general; presentation of voiding dysfunction and poor postural control; have a signature of the Informed Consent Form (TCLE) signed by the parents or guardians; if a child is literate, he will be invited to sign the Assent Term	Withdrawal from participating in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-2fmytmx	What are the common characteristics of patients who need to receive a blood transfusion after total knee replacement surgery?	Other	Observational	2022-04-11	<NULL>	<NULL>	5336	What is the profile of patients candidating for Hemotransfusion after a Total Knee Arthroplasty?	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-05-15	Instituto Nacional de Traumatologia e Ortopedia INTO	Instituto Nacional de Traumatologia e Ortopedia INTO	https://ensaiosclinicos.gov.br/rg/RBR-2fmytmx	<NULL>	patients with knee osteoarthrites undergoing total knee arthroplasty; both genders; no age limits.	patients with previous knee arthroplasty that failed requiring revision surgery.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-7qwsyny	Understanding of individuals with Parkinson´s Disease about social isolation and ways of prevention, monitor, and Treatment Remotely to face the COVID-19 pandemic.	Data analysis completed	Intervention	2022-04-11	<NULL>	<NULL>	5337	Perception of individuals with Parkinson´s Disease about social isolation and strategies of prevention, monitoring, and treatment through Telehealth to face the COVID-19 pandemic	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-21	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-7qwsyny	<NULL>	Diagnosis of idiopathic Parkinson´s disease confirmed by a movement disorders specialist in accordance with Parkinson’s Disease Society Brain Bank diagnostic criteria; both genders; age over 50 years; disease staging between 1.5 and 3 according to the modified Hoehn and Yahr scale; undergoing regular and stable pharmacological treatment; Mini-Mental State Examination score major ou equal to 24; no other associated neurological, musculoskeletal and/or cardiorespiratory diseases and the ability to walk independently; having a smartphone or computer and access to internet; knowledge about or available assistance on how to make video calls; and the ability to participate and provide written informed consent	Diagnosis of atypical Parkinson´s disease; neuropsychiatric comorbidities; inability to walk 10 meters; presence of severe dyskinesia that prevents the participant from sitting in a chair; not understanding any of the training protocol stages and experiencing severe pain and/or discomfort that precludes performing the proposed activities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-9c7pkd8	Efficacy of a Health Education Program on physical activity and food consumption in schoolchildren	Not yet recruiting	Intervention	2022-04-08	<NULL>	<NULL>	5333	Efficacy and effectiveness of a Health Education Program regarding the practice physical activity and food consumption in schoolchildren in a southern Brazilian county: a controlled community trial	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-06-20	Universidade Federal do Rio Grande	Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-9c7pkd8	<NULL>	All high schools in the state public network in the municipality of Rio Grande will be included in the Health Education Program; schoolchildren of both sexes aged between 14 and 17 years old and duly enrolled; first year high school students	Students who have physical and or cognitive limitations that prevent them from completing the self-administered questionnaires and performing the physical assessments will be excluded; students who are in the gestational period or who are breastfeeding; schoolchildren outside the age group of 14 to 17 years; students who do not reach a minimum attendance of fifty percent in the activities proposed by the Health Education Program	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-3tkjtpw	Use of a mobile application for professional management and communication and use of a game through virtual reality at the beginning of recovery after stroke	Not yet recruiting	Intervention	2022-04-08	<NULL>	<NULL>	5334	Use of an Application as a Management and Professional Communication tool and use of a Serious Game through non-Immersive Virtual Reality in the Initial Phase of Rehabilitation after Stroke	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-3tkjtpw	<NULL>	Patients diagnosed with ischemic and hemorrhagic stroke 24 hours after the injury; both sexes; older than 18 years; able to remain seated without support; ability to move the affected limb against gravity (specifically, shoulder flexor and abductor muscle groups, elbow flexor-extensor muscles, and fingers)	Patients with previous stroke; partial or total anopsia; cognitive deficits; coordination disorders in the upper limb; amputation at any level of the affected upper limb	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-8cz9kfq	Capsiate supplementation plus resistance training in adults	Data analysis completed	Intervention	2022-04-06	<NULL>	<NULL>	5331	Changes on performance, body composition and biochemical parameters in young adults after acute and chronic pre-workout supplementation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-8cz9kfq	<NULL>	Men aged between 18 and 35 years; healthy; untrained for resistance training and without chronic diseases; do not make use of food supplements and steroids	Participants who miss more than three training sessions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-10gyv7wn	Neuromuscular evaluation method	Recruiting	Observational	2022-04-06	<NULL>	<NULL>	5332	Feasibility and safety of muscle assessment by FES-Cycling	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-01	Thainá de Gomes Figueiredo	Pronto-Socorro Cardiológico de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-10gyv7wn	<NULL>	The study included individuals over 18 years of age; of both sexes; quadriparetic; mechanically ventilated	Patients with hemodynamic instability (mean arterial pressure greater than 65 or greater than 110 millimeters of mercury) were excluded; patients with musculoskeletal deficiencies or deficiencies that prevent the performance of Fes-Cycling	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-64g476p	Comparative evaluation of At-home bleaching in patients with two different age groups - a parallel, single-blind, non-randomized controlled trial.	Not yet recruiting	Intervention	2022-04-06	<NULL>	<NULL>	6270	Clinical evaluation of the efficacy of at-home dental bleaching in patients of different age groups	<NULL>	n/a, non-randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2023-08-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-64g476p	<NULL>	Patients aged between 15 and 24 years (young patients); patients between 45 and 59 years old (middle-aged adult patients); elderly patients (60-80 years); presenting a good state of general and oral health; absence of caries; absence of restorations bigger than 1/3 of tooth structure and endodontic treatment in anterosuperior teeth; with upper right canine (element 13) the participants must present color A2 or lesser value according to the value-oriented color scale (Vita Classical, Vita Zahnfabrik, Bad Sa¨ckingen, Germany).	Participants using an orthodontic appliance; severe internal discoloration of the tooth (tetracycline stains, fluorosis and non-vital teeth); bruxism; pregnant / lactating women; use of medications (analgesics or anti-inflammatory drugs); participants who had already undergone previous tooth whitening.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-3h5hffm	Does caffeine improve bodybuilding performance?	Recruiting	Intervention	2022-04-05	<NULL>	<NULL>	5329	Caffeine supplementation: ergogenic resource or placebo effect?	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-15	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-3h5hffm	<NULL>	Being 35 and 50 years old. Being bodybuilders for at least 1 year; healthy; male; non-users of nutritional supplements; non-users of drugs (licit or illicit); not having suffered musculoskeletal injuries in the last 3 months	Having irregular frequency of training; bone deformities; not understanding the instructions related to the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-9rx83cv	Effects of OzoneTherapy on Abdominal Fat Reduction	Recruitment completed	Intervention	2022-04-05	<NULL>	<NULL>	5330	Effects of OzoneTherapy in the Treatment of Localized Abdominal Fat	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-06-15	Universidade Potiguar	Universidade Potiguar	https://ensaiosclinicos.gov.br/rg/RBR-9rx83cv	<NULL>	In the inclusion criteria, participants must be aged between 25 and 45 years, Body Mass Index (BMI) between 18.5 and 29.99 (Normal to Overweight), not regular practitioners of physical activities and must have the ability to understand and preserved local sensitivity.	The exclusion criteria will apply to all participants who are allergic to ozone, are under dietary restriction (diet, dietary re-education, etc.), are using anti-inflammatory medications up to 1 week before the start of the study. If any of the volunteers need to take medication within 1 month after the start of the study, they will be discarded from the sample, present any contraindication related to ozone therapy, such as hyperthyroidism or decompensated arterial hypertension, severe anemia, recent bleeding of organs, cachexia and pathologies with high stress oxidative. Participants who do not agree with the procedures, present sensitivity disorder during therapy, or do not adapt to the schedules and procedures will be discontinued from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-46vhrkj	Neuromodulation in patients undergoing hemodialysis	Data analysis completed	Intervention	2022-04-04	<NULL>	<NULL>	5326	Transcranial Direct Current Stimulation for pain and functionality in patients undergoing Hemodialysis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-46vhrkj	<NULL>	Age between 18 and 75 years; previous medical evaluation with clinical diagnosis of depression, anxiety, chronic pain and pressure lability and being on hemodialysis treatment	Evidence of any cognitive deficit (senile dementia, Alzheimer&apos;s); presence of physical and / or organic difficulties; individuals with severe cardiovascular risk or hemodynamically unstable; history of seizures or epileptic disease; pregnancy; metallic implants in the head or neck and cardiac pacemaker.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-4ttd9yc	Use of anti-inflammatory eye drops after laser therapy for glaucoma treatment	Not yet recruiting	Observational	2022-04-04	<NULL>	<NULL>	5327	Use of anti-inflammatory eye drops after selective laser trabeculoplasty: a randomized clinical trial	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-05-01	Hospital Oftalmológico de Brasília	Hospital Oftalmológico de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-4ttd9yc	<NULL>	Patients with primary open-angle glaucoma or ocular hypertension or pseudoexfoliative glaucoma or pigmentary glaucoma or pigment dispersion syndrome, with inadequate control of intraocular pressure or intolerance to topical treatment, that will undergo selective laser trabeculoplasty (SLT). Patients approached must be at least 18 years of age on the date of the procedure and be able to undergo post-SLT follow-up for at least 12 months	Angle-closure glaucoma; Any previous glaucoma surgery; Any previous corneal procedure (refractive surgery, intrastromal rings, corneal transplant); Pregnant women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-7fpjgmj	Evaluation of an exercise program using a smartphone to control low back pain	Recruitment completed	Intervention	2022-04-01	<NULL>	<NULL>	5323	Development and evaluation of a mobile application for self-management of functionality in patients with low back pain	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-11-10	Centro Universitário São Camilo	Centro Universitário São Camilo	https://ensaiosclinicos.gov.br/rg/RBR-7fpjgmj	<NULL>	The study included patients with low back pain; aged between 18 and 70 years; BMI (body mass index) between 18-35 kg/m2; both sex; having an Android or IOS smartphone; internet at home	Subjects with restrictions to exercise; undergoing physical therapy treatment; using walking aids; those who had spinal surgery in the last 12 months were not eligible to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-89mvgbm	Effects of dual task training and tDCS in children with spastic cerebral palsy	Data analysis completed	Intervention	2022-04-01	<NULL>	<NULL>	5324	Motor-cognitive dual task associated with anodic Transcranial Direct Current Stimulation in children with Spastic Cerebral Palsy: controlled, randomized and double bling clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-01	Universidade Federal de São Paulo	Centro de Neuroestimulação Pediátrica	https://ensaiosclinicos.gov.br/rg/RBR-89mvgbm	<NULL>	Diagnosis of spastic cerebral palsy; functional classification on Levels I, II or III of the Gross Motor Function Classification System (GMFCS); ability to walk independently in at least the previous 12 months, even if requiring a gait-assistance device; age between six and 12 years (age corresponding to the period of concrete operations and logical thinking); degree of understanding and cooperation compatible with the execution of the proposed activities; statement of informed consent signed by a legal guardian and statement of informed assent signed by the participant.	Children that having been submitted to surgical procedures or neurolytic block in the 12 months prior to the onset of the training sessions; orthopedic deformities with indication for surgery; epilepsy; metal implants in skull or hearing aids; intellectual disorder that would limit the execution of the intellectual activities proposed in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-3xvgcsz	Use of vocal exercises in subjects with cleft lip and palate: randomized clinical trial	Recruiting	Intervention	2022-04-01	<NULL>	<NULL>	5325	Speech therapy intervention program with semi-occluded vocal tract exercise in subjects with cleft lip and palate: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-24	Hospital da Criança Santo Antônio - Irmandade Santa Casa de Misericórdia de Porto Alegre/ Rio Grande do Sul	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	https://ensaiosclinicos.gov.br/rg/RBR-3xvgcsz	<NULL>	Present cleft lip and palate corrected by labiaplasty, palatoplasty or both; Be between four and twelve years old; Attend the research sites during speech therapy sessions and present 75% of attendance at the sessions.	Present diagnosed genetic syndromes related or not to the presence of cleft; Present facial malformations, in addition to cleft lip and palate, that compromise the functioning of the velopharyngeal sphincter; Presence of cognitive impairment that impairs the performance of the assessment and/or therapeutic intervention; Present inability to carry out the exercise with semi-occluded vocal tract (SOVTE); Present posterior oro-nasal fistula; Inability to produce the voiced labiodental fricative phoneme; Have undergone palatoplasty less than three months ago; Have been discharged due to completion of speech and/or voice speech therapy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-7gvnk63	Effect of Low and Medium Frequency Currents on voice, pain and electrical activity of the cervical muscles	Recruiting	Intervention	2022-03-31	<NULL>	<NULL>	5318	Effect of the Application of Low and Medium Frequency Currents on vocal quality, pain and electrical activity of the cervical muscles	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-28	Universidade Estadual Paulista - Faculdade de Filosofia e Ciências -  Campus de Marília	Universidade Estadual Paulista - Faculdade de Filosofia e Ciências -  Campus de Marília	https://ensaiosclinicos.gov.br/rg/RBR-7gvnk63	<NULL>	women; between 18 and 31 years; with a history of frequent neck pain	smokers; daily alcohol users; history of cognitive or neurological problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-559x2b3	Effectiveness of electroacupuncture and laseracupuncture in the health of post-covid-19 patients: randomized clinical trial	Not yet recruiting	Intervention	2022-03-31	<NULL>	<NULL>	5319	Effectiveness of electroacupuncture and laseracupuncture in the health of post-covid-19 patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-15	Universidade Estadual de Maringá	Universidade Estadual de Maringá	https://ensaiosclinicos.gov.br/rg/RBR-559x2b3	<NULL>	Age between 18 and 59 years; history of positive testing for SARS-Cov-2; with new or persistent symptoms since the acute phase of the disease lasting at least two months, unexplained by an alternative diagnosis; that has one or more of the following characteristics: altered spirometry parameters; fatigue score greater than 4; anxiety score equal to or greater than 11; score on the depression scale equal to or greater than 8; not having a contraindication factor for performing electroacupuncture and laseracupuncture; not being on specific clinical treatment for the post-COVID-19 syndrome; present agreement with the Free and Informed Consent Form signed in two copies; agree to participate in the proposed tests.	Institutionalized people; who do not present the signature of the Free and Informed Consent Form; who do not fit into the aforementioned age group; history of carcinoma; neoplasms; physical disability; motor and/or cognitive; use of metallic prostheses; pacemaker; photosensitivity history; contraindication for the use of photobiomodulation (melanin changes; history of burns); current treatment/follow-up other than usual care. Pregnant women, people with severe mental disorders, risk of suicide attempt, people with hormonal disorders, people who are under any therapeutic intervention of traditional Chinese medicine will also not be included.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-98h5zxw	Application dose of photoestimulation on neuromuscular, functional variables and post-exercise recovery: randomized clinical trial	Recruitment completed	Intervention	2022-03-31	<NULL>	<NULL>	5320	Dose-response of clustered photobiomodulation on neuromuscular, functional variables and post-exercise recovery: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-10	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-98h5zxw	<NULL>	Young people who do not practice systematic physical activities, aged between 18 and 35 years old, of both sexes. Those who did not have neurological and cognitive impairments, cardiorespiratory diseases and a history of joint or muscle damage in the last six months, as well as chronic injuries.	Present any type of muscle and / or joint injury during the collection period or have sought consent to participate in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-7fsjmyc	The effect of auricular acupuncture on anxiety in pregnant women	Recruiting	Intervention	2022-03-31	<NULL>	<NULL>	5321	Effect of auricular acupuncture on anxiety in pregnant women in primary health care: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-14	Universidade Estadual de Montes Claros	Universidade Estadual de Montes Claros	https://ensaiosclinicos.gov.br/rg/RBR-7fsjmyc	<NULL>	Pregnant women over 18 years old; up to the gestational age of 37 weeks; availability of time for treatment; and clinically relevant anxiety.	Pregnant women using benzodiazepines, antidepressants or anxiolytics; in treatment with energy therapies or performed them in the last three months; infection, inflammation or injury to the pinna; microporous tape allergy; use of piercing at the insertion site of the devices; anatomical alteration in the hearing aid; missing in more than two consecutive sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-26bhg4z	Cognitive Therapy Based on Mindfulness and Treatment Resistant Depression: A study comparing two groups	Not yet recruiting	Intervention	2022-03-31	<NULL>	<NULL>	5322	Mindfulness-based cognitive therapy and Depression resistant to treatment: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-26bhg4z	<NULL>	Participants aged 18 or over; major depressive disorder according to the DSM-V criteria; a score equal to or greater than 18 points on the Hamilton Depression Scale (HAM-D17)	without diagnosis of major depressive disorder DSM-V criteria; diagnosis of schizophrenia or other psychotic symptoms; meet the DSM-V criteria for alcohol or substance abuse or addiction within 3 months before entering the study; had been practicing meditation or yoga for at least two months; have cognitive impairment (score &lt;22 on the MMSE); are in individual or group psychotherapy and are not willing to discontinue treatment for the duration of 8 weeks of study treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-2k5qttp	Neuromodulation for Pain in Diabetic Polyneuropathy	Recruiting	Intervention	2022-03-30	<NULL>	<NULL>	5316	Transcranial Direct Current Stimulation and the  potential therapeutic approach in different populations	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2k5qttp	<NULL>	Participants were selected from a specialized outpatient service and regarded as suitable to participate in this study if they fulfilled the following criteria: clinical diagnoses of diabetic polyneuropathy; aged from 30 to 70 years; not lactating; no history of brain surgery, tumor, or intracranial metal implantation	Participants with any uncontrolled clinical disease, such as thyroid disease, cardiovascular, pulmonary, haematological or renal disease; alcohol or other substance abuse; pregnancy; lactation; neuropsychiatric disorders; history of epilepsy and metallic implants in the head were excluded. Patients with significant cognitive dysfunction were excluded. Patients were carefully evaluated by a physician	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-3bhbrb5	The effects of dance therapy on Parkinson&apos;s disease symptoms	Recruiting	Intervention	2022-03-30	<NULL>	<NULL>	5317	Dance as an adjuvant therapy in the rehabilitation of patients with Parkinson&apos;s disease: clinical and methodological trials	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-02-10	Universidade Federal do Pará	Universidade Federal do Pará	https://ensaiosclinicos.gov.br/rg/RBR-3bhbrb5	<NULL>	Diagnosis according to the UK Parkinson&apos;s Disease Society Brain Bank; Hoehn and Yahr stage I to III; under pharmacological treatment for at least 3 years; and in physical conditions to perform the dance intervention.	People without physical conditions to perform the tests and dance intervention; who have other neurological or neuropsychiatric conditions; or have serious comorbidities that may pose a risk for the practice of physical activities.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-7fvcjkz	Comparison between two treatments for Burning Mouth	Data analysis completed	Intervention	2022-03-30	<NULL>	<NULL>	6794	Comparative analysis of Burning Mouth Syndrome Treatment using Low Power Laser (LTTP) and Transcutaneous Electrical Nerve Stimulation System: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Departamento de Odontologia - Universidade Federal do Rio grande do Norte	Departamento de Odontologia - Universidade Federal do Rio grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-7fvcjkz	<NULL>	Individuals of both sexes, over 18 years of age; subjects who had recurrent intraoral or dysesthetic burning sensation daily for more than 2 hours a day for more than 3 months without clinically evident causal lesions; individuals who presented a sensation of pain, burning or burning in the oral mucosa and who presented some local or systemic factor that justified such symptoms; individuals who were physically and emotionally able to participate in the study tests	Subjects who did not complete the study treatment protocol; individuals who presented clinical alterations in the oral mucosa	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-33dkw9y	Photobiomodulation and sensory-motor exercises program in women with knee osteoarthritis	Terminated	Intervention	2022-03-29	<NULL>	<NULL>	5311	Photobiomodulation and sensory-motor exercises program in women with knee osteoarthritis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-33dkw9y	<NULL>	Women aging between 55 and 70 years; with pain in the knee in the previous 6 months (reporting a pain level more than 2 points on the Numeric Rating Pain Scale (NPRS); unilateral or bilateral knee osteoarthritis (KOA) diagnosis (based on the criteria established by the American College of Rheumatology and grades 2 or 3 of the Kellgren &amp; Lawrence classification and observed in the radiographic image by a specialist). Also, volunteers should present body mass index (BMI) between 22 to 35 kg/m2, should be classified as irregularly active according to Criteria established by the International Physical Activity Questionnaire – Short Version (IPAQ).	Women with lung diseases; cardiologic alterations; uncontrolled hypertension and diabetes mellitus; presenting any kind of previous musculoskeletal injury in the quadriceps femoris and hamstring muscles; orthopedic or rheumatic diseases; fibromyalgia; pain that may prevent the physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-2w4dpg5	Clinical trial on central catheter cutting	Recruitment completed	Observational	2022-03-29	<NULL>	<NULL>	5313	Randomized controlled clinical trial on cutting peripherally inserted central catheters	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-02-05	Clélia Mozara Giacomozzi	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-2w4dpg5	<NULL>	Newborns hospitalized during the data collection period, who have the peripherally inserted central catheter indication and who have successfully performed the insertion procedure, whose guardians authorize participation	Newborns whose guardians do not authorize participation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-109sw26m	Comparison of methods to better analyze Denture-type Oral Prostheses for toothless patients	Recruitment completed	Observational	2022-03-29	<NULL>	<NULL>	5314	Evaluation of Masticatory Capacity, Maximum Bite Force, Salivary Flow, Quality of Life and Nutritional Status of elderly people submitted to different rehabilitations	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-03-03	Grupo de Pesquisa em Prótese Total	Universidade Estadual Paulista Júlio de Mesquita Filho	https://ensaiosclinicos.gov.br/rg/RBR-109sw26m	<NULL>	age between 60 and 80 years old; both genders; class I intermaxillary relationship;  angulation of artificial teeth Biotone Vita - 33º;  low or moderate alveolar bone resorption (Kapur index);  no report of an allergy to the chewing gum properties, almond, and Optocal silicone;  bimaxillary complete dentures users between 1 and 5 years in good condition.	neuromuscular dysfunction; psychological changes; xerostomia; presence of oral pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-87pw366	Effects of upper and lower limb exercises on patients after COVID-19.	Recruiting	Intervention	2022-03-29	<NULL>	<NULL>	5315	Effects of a post-Covid-19 cardiopulmonary rehabilitation protocol: a clinical trial	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-20	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-87pw366	<NULL>	Both genders; 18 years of age or older; confirmed diagnosis of COVID-19 by RT PCR test; have a computed tomography scan of the chest.	Participants who develop any disabling condition for participation in the study will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-2gq7mqr	Acupuncture in muscle fatigue	Not yet recruiting	Intervention	2022-03-29	<NULL>	<NULL>	5362	Effect of acupuncture on muscle fatigue	<NULL>	n/a, n/a, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-03	Faculdade Motricidade Humana	Faculdade Motricidade Humana	https://ensaiosclinicos.gov.br/rg/RBR-2gq7mqr	<NULL>	Healthy men; aged between 18 and 30 years; practicing regular physical exercise, at least twice a week	Recent lower limb injuries; lower limb prosthesis; Body Mass Index &gt;25; use of muscle myorelaxant; needle phobias	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-8zbys7m	Metabolic profile of frail and pre-frail elderly women and its response to exercise	Not yet recruiting	Intervention	2022-03-28	<NULL>	<NULL>	5308	Metabolomic profile of frail and pre-frail elderly women and its chronic response to exercise: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Faculdade de Educação Física da Unicamp	Faculdade de Educação Física da Unicamp	https://ensaiosclinicos.gov.br/rg/RBR-8zbys7m	<NULL>	Women over 65 years old	Engaging in exercise programs in the six months preceding the beginning of the experimental design; consumption of nutritional supplements and anabolic steroids in the six months preceding the beginning of the experimental protocol; adherence to restrictive diets; nephropathies, hyper or hypothyroidism, cancer, or obstructive lung disease; untreated arterial hypertension; diabetes mellitus; body mass index greater than 35 kg / m2; smoker; cognitive impairment; any cardiovascular, neurological or musculoskeletal problem that makes physical exercise unfeasible.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-73yp7vc	Immediate and medium-term effect of photobiomodulation on vocal fatigue in professionals of the voice	Not yet recruiting	Intervention	2022-03-28	<NULL>	<NULL>	5309	Immediate and medium-term effect of photobiomodulation on vocal fatigue in professionals of the voice	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-73yp7vc	<NULL>	Professional voice men and women; with vocal fatigue complaint; with a clinical diagnosis of behavioral dysphonia; age group from 18 to 45 years	Volunteers under the age of 18 and over 46; that present in the vocal folds; phonotraumatic injuries; organic; neurological changes; previous laryngeal surgeries; vocal fold hemorrhages at the time of evaluation; upper airway infections in the last 2 weeks, active tumor processes; who were previously submitted to speech therapy in the voice area; active smokers; pregnant women; menopausal women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-5q6x56k	Monitoring heart disease patients via WhatsApp during the COVID-19 pandemic	Data analysis completed	Intervention	2022-03-28	<NULL>	<NULL>	5310	Follow up of outpatients with heart failure with reduced ejection fraction via WhatsApp during the COVID-19 pandemic	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2020-06-01	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-5q6x56k	<NULL>	Patients were eligible for inclusion if they were 18 years of age or older, had heart failure with an ejection fraction less than or equal to 40%, regardless of etiology, assessed by an echocardiogram performed within a maximum of six months before randomization, functional class I- III (New York Heart Association), optimized drug therapy, cell phone with access to the Whatsapp® application.	Patients with any non-cardiac condition that, in the investigator&apos;s opinion, leads to a life expectancy of less than 12 months, functional class IV (NYHA), cardiogenic shock, cardiac surgery within the previous 8 weeks, heart transplant waiting list, failure chronic kidney disease, uncontrolled high blood pressure, inability to understand or interact with text messages due to illiteracy, cognitive impairment or social problems, severe depression and uncontrolled arrhythmia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-2rgxbdv	Effect of Immunological Reactions of Dexmedetomidine when used in patients undergoing Video-Assisted Gallbladder Removal	Data analysis completed	Intervention	2022-03-28	<NULL>	<NULL>	5833	Immunomodulatory effect of Dexmedetomidine as an adjuvant drug in patients undergoing laparoscopic Cholecystectomy	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2022-04-01	Gustavo Nascimento Silva	Hospital Universitário Gaffree e Guinle	https://ensaiosclinicos.gov.br/rg/RBR-2rgxbdv	<NULL>	Patients classified as physical health status 1 and 2; Laparoscopic Cholecystectomy Surgery; Patients who signed the Free and Informed Consent Form	Patients classified as physical health status more than 2 ;Conversion to open surgery;Emergency Surgeries	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-10qfrrgh	Can the size of the wear near the gingiva affect pain intensity and imaging findings?	Data analysis completed	Observational	2022-03-27	<NULL>	<NULL>	5305	Analysis of dental pain and pulp status in teeth with non-carious cervical lesions and dental hypersensitivity- clinical, radiographic and tomographic diagnosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-09-13	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-10qfrrgh	<NULL>	Participants included in this study, should be at least 18 years old, in good general and oral health and were required to have NCCL (Non-carious cervical lesions).	Teeth with presence of dental caries and restorations or fractures were excluded. Participants who underwent recent periodontal surgery or desensitizing treatment in the last three months and those with dental prostheses and orthodontics apparatus, teeth with or under endodontic treatment. In addition, pregnant and lactating women, individuals with bruxism or any systemic/psychological diseases, anti-inflammatory or analgesic drug users, smokers or patients undergoing tooth-whitening procedures were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-6ybmgcv	Use of laser light in association with a gel containing hyaluronic acid and L-glutamine amino acid for the treatment and prevention of oral wounds caused by treatment with radiotherapy and chemotherapy in the head and neck region	Recruiting	Intervention	2022-03-27	<NULL>	<NULL>	5306	Photobiomodulation Therapy associated with L-Glutamine and Hyaluronic Acid for the Prevention and Treatment of Oral Mucositis in patients with Head and Neck Cancer undergoing Chemoradiation Therapy: Randomized Controlled Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Faculdade de Odontologia da Universidade Federal de Goiás	Faculdade de Odontologia da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-6ybmgcv	<NULL>	Patients diagnosed with oral or oropharyngeal cancer; of both sexes; over 18 years old; treated with adjuvant or exclusive radiotherapy	Salivary gland tumors; Sjogren&apos;s Syndrome; infectious diseases of salivary glands; palliative radiotherapy; recurrent tumors; lymphoma diagnosis; diagnosis of melanoma; diagnosis of skin cancer; inability to self-care	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-3hh8kxq	Analysis of bad breath in individuals with bone necrosis in the jaws	Recruiting	Observational	2022-03-27	<NULL>	<NULL>	5307	Analysis of volatile sulfur compounds in individuals with medication-related osteonecrosis of jaws	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-14	Universidade de São Paulo - Campus Bauru	Universidade de São Paulo - Campus Bauru	https://ensaiosclinicos.gov.br/rg/RBR-3hh8kxq	<NULL>	Individuals over 18 years of age with a confirmed diagnosis of medication; related osteonecrosis of the Jaw according to clinical and imaging criteria according to the American Association of Oral and Maxillofacial Surgeons Annual Meeting; who are being monitored at the Clinical Research Center University of São Paulo Bauru	History of head and neck cancer and undergoing radiotherapy in the head and neck region; current diagnosis of infection in the upper and or lower respiratory tract; gastric reflux; pregnancy; lactation; liver failure; individuals undergoing hemodialysis; individuals with a history of diseases that may pose a risk to themselves or to the evaluator such as sarcoidosis tuberculosis severe heart disease drug or alcohol abuse graft versus host disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-2fbw8dt	How is oral desensitization in patients with milk allergy	Recruitment completed	Observational	2022-03-26	<NULL>	<NULL>	5304	Assessment of the response to oral desensitization in patients with milk allergy	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2015-05-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2fbw8dt	<NULL>	Patients over three years old; diagnosis of persistent IgE-mediated cows milk allergy with compatible and reproducible immediate symptoms for less than one year or recent positive oral test (one year interval); severe cows milk allergy: as reported or recorded in the medical record of anaphylaxis history; specific IgE for milk, alpha-lactalbumin, beta-lactoglobulin or casein positive by the ImmunoCAP method; positive prick test with a diameter greater than or equal to three millimeters of the negative control for milk in natura; and possess self-injecting adrenaline	Patient diagnosed with cows milk allergy with some degree of tolerance; patient with non-IgE-mediated cows milk allergy; patient with eosinophilic esophagitis prior to immunotherapy; patients with uncontrolled asthma; patients with cardiovascular diseases or other diseases and therapies that contraindicated the use of adrenaline; patients with serious systemic diseases such as autoimmune diseases and malignant neoplasms; and patients and/or caregivers who have difficulty understanding the purpose of treatment, following treatment instructions, and recognizing and treating adverse reactions (not familiar with the action plan)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-4m5pdbf	Anesthesia without Narcotic Analgesic for Obesity Surgery: is there a benefit?	Data analysis completed	Intervention	2022-03-25	<NULL>	<NULL>	5300	Opioid-free Anesthesia for Laparoscopic Gastroplasty: is there a benefit?	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-01-13	Universidade Federal do Paraná	Hospital Nossa Senhora das Graças	https://ensaiosclinicos.gov.br/rg/RBR-4m5pdbf	<NULL>	Body mass index major or equal to 35; indication for gastroplasty surgery; age over 18 yers old	Refusal to participate in the study; chronic pain or chronic use of analgesics; any condition or pathology that could change the perception of pain; heart blockages or major arrhythmias; patients anesthetized differently from the proposed protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-682j2q7	Root canal treatment in molar teeth using two types of Systems - Rotary or Reciprocating	Recruiting	Intervention	2022-03-25	<NULL>	<NULL>	5301	Negotiability of the mesiopalatal canal in maxillary molars using a Rotary or Reciprocating System: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-20	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-682j2q7	<NULL>	Patients of both sexes; over 18 years of age; in need of endodontic treatment in first and second permanent upper molars will be included	Patients under 18 years of age; with cognitive difficulties, unable to consent to treatment will be excluded; upper molars that require endodontic retreatment; teeth where the second MesioBuccal root canal is not found; access through prosthetic crowns; cases with incomplete rhizogenesis; patients who do not agree to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-7gstxs6	Antimicrobial action of cleaning methods for dentures of hospitalized patients	Terminated	Intervention	2022-03-25	<NULL>	<NULL>	5302	Antimicrobial effectiveness of denture cleaning protocols for hospitalized patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-10-01	Karin Hermana Neppelenbroek	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7gstxs6	<NULL>	Patients in hospital ward; both sexes; over 18 years old; users of conventional removable upper complete; any condition of the mandibular arch; any level of consciousness; any reason for hospitalization.	Patients with fractured and/or relined upper complete dentures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-9bv3dc9	Effects of balance strength training to prevent falls in the elderly population with cognitive decline	Not yet recruiting	Intervention	2022-03-25	<NULL>	<NULL>	5303	Effects of instability resistance training for falls prevention in community-dwelling older adults with probable cognitive impairment: A randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-31	Universidade Federal do Vale do São Francisco - UNIVASF	Universidade Federal do Vale do São Francisco - UNIVASF	https://ensaiosclinicos.gov.br/rg/RBR-9bv3dc9	<NULL>	Participants both sex, male or female, aged 65 and older; are able to walk 10 meters without assistance; present subjective cognitive complaints and / or score less than 26 (of a total of 30 points) in Montreal Cognitive Assessment (MoCA); live independently in the community; and be able to read, write, speak and understand in the Portuguese language	Be engaged in structured exercise (e.g. aerobic, resistance or mind-body exercise classes) in the last three months; have had a clinical condition that interferes with exercise (e.g., angina pectoris); have had a previously diagnosed cardiovascular (e.g., stroke), neurodegenerative (e.g., Parkinson’s disease) or psychiatric (e.g., major depression) disease; have severe musculoskeletal or vestibular disorders; or are unable to complete the assessments or intervention due to inadequate vision and/or hearing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-5ydbctk	Study of a Device for Bone Augmentation in maxilla	Data analysis completed	Intervention	2022-03-24	<NULL>	<NULL>	5298	Evaluation of a New Device for Horizontal Bidirecional Bone Augmentation in maxila: a clinical and tomographic analysis	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2019-10-10	Luís Guilherme Scavone de Macedo	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-5ydbctk	<NULL>	Ages between 18 and 65 years, who have bidirectional horizontal maxilla atrophy and who intend to have oral rehabilitation with the use of osseointegrated implants.	Pregnant, diabetics, immunocompromised patients, smokers, who are using medications that may interfere with the study results. Patients who present fracture of the bone walls during the procedure make it impossible to fix the device.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-8c2qyhj	Effect of intestinal imbalance on the defense cells of the body	Recruiting	Intervention	2022-03-24	<NULL>	<NULL>	5299	Investigation of the effect of Gut Dysbiosis on histone post-translational modifications in neutrophils	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-01	Instituto de Biologia - Universidade Estadual de Campinas	Instituto de Biologia - Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-8c2qyhj	<NULL>	Male, volunteer subjects; age between 20 and 29 years; eutrophic (Body Mass Index between 18.5 and 29.9); non smokers; in good general health.	Recent (up to 60 days before treatment) history of: antibiotic or corticosteroid therapy; vaccination; continuous drug therapy. Diagnosis or clinical signs of: metabolic diseases; acute or chronic inflammatory diseases ; autoimmune diseases; allergy or atopy; cancer; digestive system diseases; acute or chronic infectious disease known to impair general health or immune responses (for examples: HIV infection, hepatitis C, influenza, acute herpes simplex); depression, hypochondria, or other psychiatric illnesses that may lead to risky behaviors. Not mentioned conditions that may interfere with the study will follow medical advice regarding exclusion or permanency in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-3v7mrsq	Use of Low Power Laser in wound healing in Diabetic foot: Randomized clinical trial	Recruiting	Intervention	2022-03-23	<NULL>	<NULL>	5297	Photobiomodulation in foot ulcer tissue repair Diabetic: Randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-05	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-3v7mrsq	<NULL>	Will be included in this study volunteers who complete the following criteria:Be 18 years of age or older; Present a clinical diagnosis of type II diabetes; Being monitored at the outpatient clinic of the HMI vascular clinic; Present ulcer located in the region of the feet, medial and distal third of the leg, classified in grade 1 and 2 of stage A, by the System of The University of Texas Diabetic Wound Classification of Texas Diabetic Wound Classification System); Ulcers with a length between 1 to 5 cm; Ulcer with onset time less than or equal to 3 months; Have preserved cognitive ability, assessed with the help of the mini exam of mental state (MMSE)	The exclusion criteria established were: Uncontrolled diabetes, measured at the time of recruitment or via information obtained from the medical record; Smoker; Alcoholic; Neuromuscular or musculoskeletal disorders; Peripheral arterial disease (PAOD), determined by measuring the ankle-arm index (ABI) less than 0.90; Conditions that contraindicate Photobiomodulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-7xj4wyp	Evaluation of the use of Telemedicine in Pediatric Intensive Care Units: Randomized Controlled Trial.	Not yet recruiting	Intervention	2022-03-22	<NULL>	<NULL>	5294	Evaluation of the Impact of Telemedicine Use on Clinical Care Indicators in Pediatric Intensive Care Units: Cluster Randomized Controlled Trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde	Programa de Apoio ao Desenvolvimento Institucional do Sistema Único de Saúde	https://ensaiosclinicos.gov.br/rg/RBR-7xj4wyp	<NULL>	All children admitted in the pediatric Intensive Care Unit (ICU) aged  bigger or equal 29 days and smaller 18 years, with a length of stay greater than 8 hours, and in case of death, greater than 24 hours	Patients with incomplete medical records or with incomplete data in the institution&apos;s database; patients whose guardians did not accept to participate in the study and/or who did not sign the Informed Consent Form (FICF) and term of use of image	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-4wdm8q9	Effect of a multimedia strategy for knowledge acquisition and reduction of caregivers of children and adolescents with cancer	Recruiting	Intervention	2022-03-22	<NULL>	<NULL>	5295	Multimedia Strategy for the acquisition of knowledge and reducing Anxiety of caregivers of children and adolescents in chemotherapy: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal do Rio Grande do Norte	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-4wdm8q9	<NULL>	The inclusion criteria of the research are caregivers of both sexes, aged 18 years or over and who is the primary caregiver of the child or adolescent with cancer who will start chemotherapy	Exclusion criteria are caregivers of children and adolescents with cancer who have a disorder that makes them unable to understand and participate in the research; caregivers of children and adolescents who are starting chemotherapy treatment with disease recurrence.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-36fh5ss	Use of probiotics in asymptomatic vaginal infection	Recruiting	Intervention	2022-03-22	<NULL>	<NULL>	5296	Use of probiotics in asymptomatic bacterial vaginosis	<NULL>	n/a, single-arm-study, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Leila Cristina Soares Brollo	Hospital Universitário Pedro Ernesto	https://ensaiosclinicos.gov.br/rg/RBR-36fh5ss	<NULL>	18 to 50 years, in pre-menopause, with cytology result indicating supracytoplasmic bacilli microbiota, no complaints	pregnant women, postmenopausal women, with immunosuppressive diseases or using immunosuppressive medication	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-9yjjxvq	Clinical evaluation of the addition of antifungal drugs to denture liner material in the treatment of oral candidiasis	Recruitment completed	Intervention	2022-03-21	<NULL>	<NULL>	5293	Clinical evaluation of the addition of antifungals to temporary resilient liner in the denture stomatitis treatment	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2015-10-01	Karin Hermana Neppelenbroek	Faculdade de Odontologia de Bauru - Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9yjjxvq	<NULL>	Volunteer users of conventional removable upper denture; clinical diagnosis for denture stomatitis in the palatal mucosa supporting the complete denture, both genders, any age, regardless of the condition of the mandibular arch and the use and status of the lower denture.	Volunteers with anemia; immunocompromised; with uncontrolled endocrinopathologies; in a therapeutic regimen with antibiotics, steroids or antifungals in the last three months; under antineoplastic treatment by radio or chemotherapy; users of the same upper complete denture for over 30 years	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-4c88hgp	Use of blue LED in the treatment of recurrent vulvovaginal candidiasis	Recruitment completed	Intervention	2022-03-21	<NULL>	<NULL>	7303	Use of blue light-emitting diode in the treatment of recurrent vulvovaginal candidiasis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-03	Hospital de Clínicas de Porto Alegre	Hospital de Clínicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-4c88hgp	<NULL>	Women of childbearing age and over 18 years old, with a history of RVC and previous unsuccessful conventional treatment, after signing an Informed Consent Form (ICF). Diagnostic confirmation will be required with specific culture for Candida or by fresh examination of vaginal secretion, associated with signs and symptoms suggestive of RVC, with a semiquantitative score of more than 4 points.	Pregnancy, diabetes mellitus, human immunodeficiency virus (HIV) infection, epilepsy, glaucoma, tuberculosis, under chemotherapy treatment, use of broad spectrum antibiotics (Tetracycline, Ampicillin, Cephalosporin), prolonged use of glucocorticoid (time equal to or greater than 3 weeks), change of contraceptive method during the study period, use of topical or oral azoles (in addition to the drugs provided) during the recruitment period, patients with a pacemaker or hip prosthesis, current and/or treated genital neoplasia, history of photosensitivity, use of photosensitive drugs, application to a bleeding area, hypersensitivity to Fluconazole or azole compounds, withdrawal of consent or loss to follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:16
RBR-2shm9jp	Development of an instrument to define the risk of respiratory complications in children undergoing non-cardiac surgery	Recruiting	Observational	2022-03-20	<NULL>	<NULL>	5289	Development of a risk model for perioperative respiratory complications in children undergoing to non-cardiac surgeries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-10-01	Hospital de Clínicas de Porto Alegre	Grupo Hospitalar Conceição	https://ensaiosclinicos.gov.br/rg/RBR-2shm9jp	<NULL>	Children under 16 years old, undergoing non-cardiac surgeries	Over 16 years old, undergoing obstetric procedures, transplants or procedures under local anesthesia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-29vzr84	Breathing muscle strength training for movement of individuals with stroke	Recruiting	Intervention	2022-03-20	<NULL>	<NULL>	5290	Inspiratory muscle training in functionality and swallowing in individuals with stroke	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-10-01	Hospital Geral Roberto Santos	Hospital Geral Roberto Santos	https://ensaiosclinicos.gov.br/rg/RBR-29vzr84	<NULL>	Individuals diagnosed with ischemic or hemorrhagic stroke; of both sexes; aged between 21 and 75 years, who present a stable clinical picture; with trunk control/balance deficit; hospitalized for treatment of the subacute event.	incapable of understanding the instructions in the tests, as well as those with aphasics and/or psychiatric disorders that make it impossible to carry out the prescribed exams; those who present oromyofunctional disorders that make it impossible to effectively use the respiratory stimulant; those with a previous history of dysphagia, orotracheal intubation or tracheostomy patients; those who present any pathology with transmission by contact or air, making the use of materials unfeasible; known heart diseases; Untreated SAH and smoking habit. During the post-discharge follow-up, deaths will be excluded; individuals who present a new episode of stroke and other comorbidities that compromise functional performance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-8d85hs4	Evaluation of the health effects of food consumption with agrochemical residues	Recruitment completed	Intervention	2022-03-20	<NULL>	<NULL>	5291	Consumption of organic and conventional food: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-05-24	Faculdade de Medicina - Universidade Federal do Rio Grande	Faculdade de Medicina - Universidade Federal do Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-8d85hs4	<NULL>	Inclusion criteria to participate in the clinical study will be individuals aged 20-40 years (young adult age group); Individuals without any cancers; or with non-communicable chronic diseases; and individuals with alcohol intake of a maximum of 30mL / day for men and half of that value for women	Individuals who do not consume fruits and vegetables will be excluded; smoking individuals; and those women who, even within the inclusion criteria, are pregnant or lactating	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-9hg547m	Comparative study of the treatment of fallen bladder with internal or external pessary	Terminated	Intervention	2022-03-17	<NULL>	<NULL>	5286	Comparative study of the treatment of pelvic organ prolapse with an internal or external pessary	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-07-01	University of São Paulo	University of São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9hg547m	<NULL>	Women with stage II pelvic organ prolapse (with point of greatest prolapse greater than 0) and III according to Pelvic Organ Prolapse Quantification System who agreed to participate in the study.	Cancer of the genitourinary tract;Post-menopausal genital bleeding;repeated urinary tract infection; short vagina; Recurrent genital infection; Impossibility of proper monitoring and maintenance of the pessary ;Contraindication to the use of estriol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-5d963p8	Effects of an electrotherapeutic modality on knee flexion movement in individuals with spastic cerebral palsy: pilot study	Terminated	Intervention	2022-03-17	<NULL>	<NULL>	5287	Effect of extracorporeal shockwave therapy on knee flexion in individuals with spastic cerebral palsy: pilot study	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2019-12-02	Universidade Estadual Paulistana	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-5d963p8	<NULL>	Ability to voluntarily perform knee extension, obtain grade II and grade III spasticity classification of the knee flexor muscles according to the modified Ashworth scale.	Unable to reach the atopic position even with the help of the therapist or auxiliary device, a process performed in any of the lower limbs in the last six months and an intellectual disability that interferes with the understanding of the procedures.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-8546xnx	Association between tinnitus, jaw joint problems, Bruxism, Migraine, psychological and emotional aspects.	Recruiting	Observational	2022-03-16	<NULL>	<NULL>	5285	Association between Somatosensory Tinnitus, TMJ, Bruxism, Headache and psychosocial aspects.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal do Paraná	Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8546xnx	<NULL>	Individuals of both sexes; aged over 18 years; without distinction of color and race; sexual orientation or social group; literate; complaining of subjective tinnitus for more than 6 months; who seek care at the Temporomandibular Disorder  and Orofacial Pain clinic of Federal University of Paraná or at the Clinical Hospital of the Federal University of Paraná; without a history of hearing loss and who wish to participate in the research voluntarily. Individuals who agree to participate must read and sign the Free and Informed Consent Form.	Pregnant women or women who are breastfeeding; presence of changes in cognitive functions and impairment and communication skills or that showed impairment in understanding the technical questionnaires; presence of odontogenic pain caused by extensive caries or dental fracture; presence of acute facial pain complaint after recent injury; complaint of pulsatile tinnitus; history of acoustic trauma; history of previous ear surgery; diagnosis of multiple sclerosis; diagnosis of Meniere&apos;s disease; condition with systemic conditions such as rheumatoid arthritis; uncontrolled hypothyroidism; diabetes; hypertension; leprosy; previously diagnosed disabling psychological and neurological changes; eardrum perforation; use of medication such as fluoxetine; high dose aspirin; diuretics; nicotine or alcohol abuse also excluded due to the possible ototoxic power of these substances.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-6r7fh2j	Root coverage of isolated gingival recessions with loss of interproximal tissues in the mandible	Recruiting	Intervention	2022-03-15	<NULL>	<NULL>	5282	Root coverage of isolated miller class III gingival recessions in the mandible. Randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-12	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-6r7fh2j	<NULL>	"Age over 18 years old;
No contraindications for performing surgical procedures, including the need for antibiotic therapy prior to dental procedures;
Have not performed previous surgeries in the involved sites;
Patients with good oral hygiene (IPV and ISG &lt; 20%);
Patients with isolated Miller Class III GR in the mandible, located in the incisors, canines or premolars;
Well identifiable presence of the cementoenamel junction (CEJ)."	"Systemically compromised patients;
Pregnant or lactating women;
Teeth with presence of abrasion, decay, crowns or restorations involving the root;
Molars with Miller&apos;s Class III GR;
Teeth with Miller Class III GR without the well-identified presence of JCE.
Patients who are smokers or ex-smokers who have stopped smoking for less than a year."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-9hpwgjy	Study on the effects of antidepressants on the brain of patients with obsessive-compulsive disorder: research towards personalized medicine	Recruiting	Intervention	2022-03-15	<NULL>	<NULL>	5283	Brain Biomarkers as Response Predictors to Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder: development of a paradigm towards personalized medicine	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-31	Instituto de Psiquiatria	Instituto de Psiquiatria	https://ensaiosclinicos.gov.br/rg/RBR-9hpwgjy	<NULL>	Male or female aged between 18 and 50 years; Main diagnosis of Obsessive-Compulsive Disorder according to DSM-5; Y-BOCS score ≥ 16; No psychotropic medication used in the last 6 weeks; No behavioral therapy or response prevention exposure focusing on Obsessive-Compulsive Disorder in the past 6 weeks; Able to tolerate a 1-week treatment-free period; and Able to provide informed consent.	"Lifetime diagnosis of psychotic disorder, bipolar disorder, anorexia nervosa, autistic spectrum disorder with IQ&lt;80, Tourette&apos;s disorder; Current chronic tic disorder (current = within the last 12 months); Disorders related to the use of current substances, including nicotine (current = within the last 12 months); Current eating disorder or bulimia (current = within the last 12 months); Acute risk of suicide. Pregnant women; Medical or neurological problems (including head trauma with loss of consciousness); Presence of metal devices on the body or dental appliances; IQ&lt;80; Cigarette use: more than 5 per day; Alcohol use: more than 2 drinks a day for women
and more than 3 drinks a day for men; Cannabis use: more than once a week."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-98b36rc	Effects of two different exercise protocols for treating women with jaw pain	Recruiting	Intervention	2022-03-15	<NULL>	<NULL>	5284	Effects of two different exercise protocols for treating women with temporomandibular disorders: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-98b36rc	<NULL>	Women with TMD diagnosed by the DC/TMD criterea; Orofacial pain intensity higher than 3 points (NPRS); Onset of pain greater than 3 months;	Participants who start a new treatment in addition to the proposed one and participants who show signs and/or symptoms of exercise intolerance; pregnant women, or women undergoing hormone replacement; women who underwent some type of non-pharmacological treatment for TMD and neck pain in the last 6 months; irregular use of an interocclusal splint in the past 6 months; other causes of orofacial pain such as caries, periodontal diseases; or who had a history of head trauma that is related to the etiology of orofacial pain confounding the diagnosis of TMD; women with intracranial disorders; history of surgery in the orofacial or cervical region; continuous use of medications in the last 3 months such as muscle relaxants, anticonvulsants, beta blockers, bronchodilators, antidepressants and anxiolytics; female smokers or former smokers with less than 1 year of interruption; who have severe arrhythmias; obese (BMI&gt;30km/m2); participants who present cardiovascular, respiratory, neurological and orthopedic diseases, which prevent the performance of physical exercise, or whose exacerbation is induced by physical exertion; neuropathies, fibromyalgia and rheumatic diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-6wgwxsy	Comparative search between  HIV medicines  in Covid-19	Not yet recruiting	Intervention	2022-03-14	<NULL>	<NULL>	5275	Randomized double-blind clinical trial comparing Atazanavir + Ritonavir + Doxycycline versus Atazanavir + Ritonavir in patients with laboratory or clinical diagnosis for Covid-19, in the state of Pernambuco and Alagoas – Brazil	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-04-01	Hospital das Clínicas da Universidade Federal de Pernambuco	Universidade Estadual de Ciências da Saúde de Alagoas - UNCISAL	https://ensaiosclinicos.gov.br/rg/RBR-6wgwxsy	<NULL>	outpacients with positive diagnosis for COVID-19	Patients with indication for hospital admission;  patients with other protease inhibitors;  pregnant;  infants;  more than 5 days  from the onset of symptoms, HIV positive patients	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-22cv4kv	The effect of the World Health Organization&apos;s iSupport in Brazil	Not yet recruiting	Intervention	2022-03-14	<NULL>	<NULL>	5276	Translation, Cultural Adaptation and the Effects of the World Health Organization&apos;s iSupport for the Brazilian Context	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Departamento de Gerontologia da Universidade Federal de São Carlos	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-22cv4kv	<NULL>	Be aged 18 years or older; report that they are a family caregiver of a person with dementia; providing non-paid care for at least 6 months at the time of the recruitment; caring for a person holding a diagnosis of dementia; have access to a smartphone, computer or tablet with internet	Unable to comprehend written Brazilian Portuguese; not having access to a device with internet connection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-678f5pf	Anxiety and depression in patients with frozen shoulder. Worst functional results obtained in cases of more severe anxiety and depression?	Recruiting	Observational	2022-03-14	<NULL>	<NULL>	5277	Anxiety and depression in patients with frozen shoulder. A cross-sectional analysis associated with functional correlation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-19	Hospital Ortopédico de Belo Horizonte	Hospital Ortopédico de Belo Horizonte	https://ensaiosclinicos.gov.br/rg/RBR-678f5pf	<NULL>	Those male and female patients; age between 18 and 75 years; those diagnosed with primary frozen shoulder of idiopathic etiology; those who have x-ray and magnetic resonance exams for differential diagnosis of their injuries	Those with secondary frozen shoulder, that is, those with a report of local trauma; history of previous surgeries; chondral injury in the glenohumeral joint; lip lesions; synovitis; intra-articular free bodies; history of prolonged shoulder immobilization; presence of heterotopic ossification; calcific tendonitis; rotator cuff injury; glenohumeral arthrosis; inveterate dislocation of the shoulder; skin burn scars at the site; history of neurological damage to the central or peripheral nervous system; those who do not register their consent by signing the free and informed consent form; those who present incomplete data in the protocol of this study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-62prx9t	Early stimulation in motor development of premature babies: randomized clinical trials	Recruiting	Intervention	2022-03-14	<NULL>	<NULL>	5278	Effectiveness of early sensory-motor stimulation in neuropsychomotor development of premature newborns: randomized clinical trials	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-27	Universidade Estadual de Londrina	Programa de Pós-Graduação em Ciências da Reabilitação - UEL/UNOPAR	https://ensaiosclinicos.gov.br/rg/RBR-62prx9t	<NULL>	Preterm infants born at less than 32 weeks of gestational age (GA) or weighing less than 1500g at birth for a period of one year will be recruited. To be included in the study, newborns (NBs) need to be hemodynamically stable (respiratory rate 40-60 rpm, heart rate 120-160 bpm, peripheral oxygen saturation above 91%) and with no signs of respiratory distress.	Those who are using invasive or non-invasive mechanical ventilation, who cannot participate in the intervention for up to 3 consecutive days, who have congenital malformations, genetic syndromes, postoperative period and grade VI intraventricular hemorrhage will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-5wmbzkw	Headache attacks triggered by ingestion of watermelon:  A source of citrulline that generates nitric oxide	Recruitment completed	Intervention	2022-03-13	<NULL>	<NULL>	5273	Migraine attacks triggered by ingestion of watermelon (Citrullus lanatus): A source of citrulline activating the L-arginine-nitric oxide pathway	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Federal University of Piauí	Federal University of Piauí	https://ensaiosclinicos.gov.br/rg/RBR-5wmbzkw	<NULL>	Medicine student; Age between 18 and 50 years old; Brazilian nationality; Agree to undergo anamnesis, watermelon ingestion and blood collections; Diagnosis of migraine or other primary headache according to ICHD-3 criteria; and Be headache-free for at least 48 hours before ingesting the watermelon.	Headache frequency greater than or equal to 15 days per month; Women with headache only during the menstrual period; Association of migraine with other primary headache; In use of migraine prophylactics; Diagnosis of secondary headaches or unclassified headache; History of citrulline amino acid allergy; Consumption of watermelon or other sources of citrulline in the last 7 days; Intake of food supplement rich in citrulline; Associated diseases that would be compromised by ingestion of watermelon; Use of medications that compromise watermelon intake Diabetic patients; and Pregnant women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-9bp2g4w	Profile of physical activity and depression in people with multiple sclerosis	Not yet recruiting	Intervention	2022-03-13	<NULL>	<NULL>	5274	Assessment of Sedentary Behavior, Physical Activity Level, Depressive Symptoms and Gait in People with Multiple Sclerosis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Faculdade de Educação Física da Universidade de Brasília	Faculdade de Educação Física da Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-9bp2g4w	<NULL>	Age between 18 and 60 years; MS diagnosis for more than one year. A score above 4 on the Patients Determined Disease Steps Scale (PDDS) and Expanded Disability Status Scale (EDSS)	Refusal to meet for data collection, previously scheduled	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-8mfwcwf	Laser Acupuncture in the treatment of neck and low back pain - randomized clinical trial	Recruiting	Intervention	2022-03-11	<NULL>	<NULL>	5272	Laser Acupuncture in the Treatment of Chronic Pain in the Cervical and Lumbar Regions - Randomized Clinical Trial	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Alfenas, UNIFAL-MG	Universidade Federal de Alfenas, UNIFAL-MG	https://ensaiosclinicos.gov.br/rg/RBR-8mfwcwf	<NULL>	Men and women aged 18 to 60 years; who have neck pain  or low back pain with or without spine stiffness for more than 3 months; self-reported pain at a score of 3 or more on the Visual Analogue Scale; willing to participate and be randomly allocated to the study groups; good cognitive to provide consent; availability of time to receive the acupuncture laser.	Fractures or cervical or lumbar surgery; history of spinal cord trauma; tuberculosis; patients with cancer; pregnancy or lactation or scheduling a pregnancy during the study period; rejection or fear of receiving the technique; having undergone energy therapy or any other treatment for the spine in the last 3 months prior to the study; being under physiotherapeutic treatment concomitant with the proposed intervention; patients with psychiatric conditions accompanied by difficulty in understanding; severe systemic disease; inability to complete research questionnaires; patients who have injuries in the regions where the laser will be applied; continued use of medication such as corticosteroids; muscle relaxants or pain relievers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-55wqx58	Effects of resistance training on the rehabilitation of athletes submitted to anterior cruciate ligament surgery	Not yet recruiting	Intervention	2022-03-10	<NULL>	<NULL>	5269	Effects of Resistance Training Periodisation on the Rehabilitations of athletes submitted to Anterior Cruciate Ligament: A randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	Universidade Federal de Ciências da Saúde de Porto Alegre	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-55wqx58	<NULL>	Male participants; Age between 18 and 40 years; Patients who underwent anterior cruciate ligament reconstruction;	Regular use of analgesics and/or anti-inflammatory drugs and food supplements; Grade III injury of the medial or lateral collateral ligament; Presence of grade IV chondropathy; meniscal suture; Meniscal injury that requires meniscectomy of a portion greater than 50% of the meniscus; Extra-articular tenodesis; Not wishing to return to sport; Previous knee, hip or ankle surgery; Posterolateral corner injury;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-99hnm43	Short-term effects of dry needling in myofascial trigger points: randomized controlled study	Recruiting	Intervention	2022-03-10	<NULL>	<NULL>	5270	Short-term effects of dry needling and electropuncture in myofascial trigger points of the superior trapezius muscle: randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-18	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-99hnm43	<NULL>	Age between 18 and 35 years old; persistent pain in the upper trapezius region for more than 6 months; presence of active or latent MTP (myofascial trigger points) in the upper trapezius muscle to be confirmed with palpation and digital pressure; analog visual scale above 5 in the trapezius region	History of surgery in the cervical region or in the shoulder girdle and shoulder; previous cervical whiplash injury; uncontrolled systemic disorders; have a cognitive deficit that prevents you from performing the proposed tests; pregnancy; needle phobia; skin lesions or infections at the application site; cervical radiculopathy or myelopathy; self-report of fibromyalgia; having performed physiotherapeutic intervention for pain in the trapezius region in the last 3 months; having used muscle relaxant and/or non-steroidal anti-inflammatory drugs (NSAIDs) in the week prior to collection or any type of medication that may mask the actual pain; contraindication for DN (dry needling): use of anticoagulants or psychiatric disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-6kcxvrc	Alternative therapies for the control of  anxiety and discomfort after wisdom molar extraction	Recruiting	Intervention	2022-03-10	<NULL>	<NULL>	5271	Alternative therapies for the control of anxiety, pain, edema, trismus and surgical disconfort in patients undergoing third molar surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-05	Departamento de Estomatologia da Universidade Federal do Paraná	Departamento de Estomatologia da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-6kcxvrc	<NULL>	Adults over 18 years of age; both sexes; no changes in general health; asymptomatic; will undergo surgery to remove third molars on both sides, with similar radiographic positions bilaterally, requiring osteotomy or odontosection.	History of taking pain or anxiety medication within 15 days prior to the study; history of hypersensitivity to drugs, substances or materials used in this experiment; pregnant women; lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-34tsc8m	Auriculotherapy in improving sleep quality in people living with HIV	Recruiting	Intervention	2022-03-09	<NULL>	<NULL>	5268	Efficacy of auriculotherapy in improving sleep quality in people living with HIV: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-34tsc8m	<NULL>	People living with HIV (PLHIV) aged 18 or over, of both sexes; On antiretroviral therapy (ART) for at least three months, a period stipulated based on the time the patient needs to adapt to the medication. According to the literature, from the first month onwards, initial adverse events are minimized, as in the case of the use of Efavirenz (EFV), which has acute effects on the central nervous system in up to 50% of patients in the first week of treatment, such as : dreams, nightmares, sadness, irritability, nervousness, dizziness and difficulty sleeping (NGUYEN et al., 2011; WATERS et al., 2011; SCOURFIELD et al., 2012; OSHINAIKE et al., 2014; ALLAVENA, 2015). Other antiretroviral drugs can also cause sleep disorders, such as Zidovudine (AZT), Stavudine (d4T), Lamivudine (3TC), Indinavir (Crixivam) (BRASIL, 2004); Complaints of poor sleep quality, confirmed by the Pittsburgh Sleep Quality Index (PSQI-BR), with scores greater than 10 (BUYSSE et al.; 1989; BERTOLAZI et al., 2011; FONSECA et al., 2010; ; KONRAD 2005); Availability for face-to-face return on the 8th and 15th days of the beginning of the intervention, and telephone assessment on the 22nd and 29th days of the intervention; Have your own landline or cell phone.	Patients with disabling mental illness; pregnant women; Homeless people and those deprived of their liberty in penitentiaries; Dermatological lesion at the site of the auriculotherapy points of the study; Allergy to the material used in the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-4kdqcbt	Effect of a two-task exercise in Virtual Reality on the physical and mental point of view in the elderly: a randomized clinical trial	Not yet recruiting	Intervention	2022-03-08	<NULL>	<NULL>	5263	Effect of a Dual Task training in Virtual Reality on physical-functional and cognitive aspects in the elderly: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Centro de Estudos Superiores de Maceió - CESMAC	Centro de Estudos Superiores de Maceió - CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-4kdqcbt	<NULL>	Seniors; Age between 60 and 79 years; both sexes; with cognitive modifications on the Mini Mental State Examination (MMSE)	Inability to understand simple verbal commands; severe visual impairment or not compensated with the use of corrective lenses; serious auditory implications; who have completed any cognitive training program in the past six months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-2bzspnz	Comparison of leg muscle size in critically ill patients in the Intensive Care Unit with ultrasound and computed tomography.	Recruiting	Observational	2022-03-08	<NULL>	<NULL>	5264	Comparison of ultrasound with computed tomography to measure skeletal muscle mass in critically ill patients: Prospective study protocol.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-06-01	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto da USP	Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto da USP	https://ensaiosclinicos.gov.br/rg/RBR-2bzspnz	<NULL>	Patients over 18 years of age, admitted to the Intensive Care Unit, victims of traumatic brain injury will be included. During the acquisition of cranial tomography exams, a quadriceps tomography will be performed to evaluate the thickness of the muscle group and compared with ultrasound. At each control cranial tomography, at the following times: 24-48 hours and 72-168 hours after admission, controls on the thickness of the quadriceps will be performed by means of tomography and ultrasonography, and these measurements will be compared for possible validation of the method.	Patients with extreme BMI (≤ 18.5 kg/m2 or ≥ 40 kg/m2), with fractures, injuries or burns in the region to be studied and patients with neuromuscular diseases, pregnant women, metastatic cancer, in end-of-life care will be excluded. and in state custody.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-8s5cbfk	Analysis of different sealers used in root canal treatment on postoperative pain in endodontics.	Recruiting	Intervention	2022-03-08	<NULL>	<NULL>	5265	Effect of calcium silicate-based sealer and epoxic resin-based sealer on post-operative pain in endodontics: a randomized clinical trial	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal do Amazonas	Universidade Federal do Amazonas	https://ensaiosclinicos.gov.br/rg/RBR-8s5cbfk	<NULL>	Men and women aged 18–65 years, diagnosed with symptomatic irreversible pulpitis with indication for endodontic treatment in permanent molar teeth, will be included in the study, confirmed by positive response to clinical, cold vitality and radiographic tests. The individual who participates in this research must have a contact number (phone or cell phone) to be able to carry out the post-operative evaluations.	Patients who were pregnant, immunocompromised, on medication or hypersensitive to anti-inflammatory drugs, or patients with occlusal disorders or any type of periodontitis or endodontic complications were excluded from the study, since these conditions would interfere with the analysis of the presence of pain after endodontic treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-7wc8dnw	Efficacy of Bone Repair in Periapical Dental Lesions Using Different Methods: Platelet Aggregates with Autologous Platelet Rich Fibrin Membranes (L-PRF) Versus Bone Repair with Clot	Terminated	Intervention	2022-03-08	<NULL>	<NULL>	5266	Evaluation of Bone Repair After Periapical Surgeries Using Leukocyte Platelet-Rich Fibrin (L PRF) and Blood Clot: A Double-Blind Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7wc8dnw	<NULL>	Presence of an apical lesion in an anterior maxillary tooth, well filled in the region surrounding the intracanal pin and with a prosthetic crown without infiltration and without any indication for removal, so that there is no risk of tooth fracture when the pin is removed; Patients that return with the active infectious process after root canal retreatment and that it is adequately shaped and filled.	As exclusion criteria: patients with systemic diseases such as diabetes mellitus blood dyscrasias, with thrombocytopenia below, 150,000 mm3	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-102g78kb	Online teaching of caring for the cardiac critical child: A Pilot Study	Recruiting	Intervention	2022-03-08	<NULL>	<NULL>	5981	Teaching pediatric cardiac critical care online: a pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-09-16	Faculdade de Medicina da Universidade de São Paulo	Escola de educação permanente do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-102g78kb	<NULL>	Last year residents of pediatric cardiology or pediatric intensive care or neonatology; voluntarily willing to participate	Refusal to participate; refusal to sign the informed consent	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:26
RBR-6bygmz9	Effect of Virtual Reality on Abdominal Contraction of sedentary young adults: randomized clinical trial	Not yet recruiting	Intervention	2022-03-07	<NULL>	<NULL>	5259	Effect of Virtual Reality on Central Stabilization of sedentary young adults: randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-18	Centro de Estudos Superiores de Maceió - CESMAC	Centro de Estudos Superiores de Maceió - CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-6bygmz9	<NULL>	Age between 18 and 29 years old; male and female individuals; sedentary academics; academics with preserved mental faculties.	Non-prosthetic amputees; academics with vestibular diseases in acute crises; academics with diseases with neuromotor impairment; academics with uncontrolled cardiovascular diseases; academics who practiced physical activities for at least four months.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-5q4gm5b	The effect of Sacubitril/Valsartan in preventing heart disease in high-risk patients undergoing chemotherapy with anthracyclines	Recruiting	Intervention	2022-03-07	<NULL>	<NULL>	5260	Double-blind, randomized, controlled study on the effect of Sacubitril/Valsartan in the prevention of cardiotoxicity in high-risk patients undergoing chemotherapy with anthracyclines	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2022-02-28	Hospital Erasto Gaertner	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5q4gm5b	<NULL>	Patients diagnosed with cancer who will undergo chemotherapy with anthracyclines and who have an increase in ultrasensitive troponin I above the 99th percentile after any chemotherapy session; age over 18 years; patients who sign the Free and Informed Consent Term	Inability to analyze ventricular function; claustrophobia; history of chemotherapy or radiotherapy; previous symptoms of heart failure; presence of cardiomyopathy ou coronary artery disease; moderate to severe aortic or mitral valve disease; contraindication to the use of Sacubitril/Valsartan such as a history of angioedema, renal artery stenosis; creatinine clearance &lt;30ml/min/m2; serum potassium &gt;5.0mEq/L; pregnant women; systolic blood pressure &lt;100mmHg; use of angiotensin converting enzyme inhibitor, angiotensin receptor blocker, Sacubitril/Valsartan, or beta-blocker; implantation of pacemaker not compatible with MRI; patients with HER 2 expression; patients with frailty or at medium-high risk of hospitalization with substantial change in chemotherapy regimen	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-8dgwp2n	Development and validation of the epidemiological diagnostic instrument for Temporomandibular Dysfunctions	Recruiting	Observational	2022-03-07	<NULL>	<NULL>	5261	Development and validation of a instrument to evaluate Temporomandibular Dysfunctions for use in epidemiological surveys	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-10-01	Departamento de Odontologia, Universidade Federal do Rio Grande do Norte	CAPES-Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8dgwp2n	<NULL>	Individuals of both sexes, aged over 18 years, with sufficient capacity to respond to the IDE/DTM and DC/TMD instruments, accept to participate after being informed about the purposes of the research and have Brazilian nationality.	Patients with a history of psychiatric illness, or those with clinical symptoms of TMD that make it impossible for dental examination or pain, as well as those who refuse to participate in the research at any of the foreseen stages will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-2mfbkkk	Clinical study of the application of Light Therapy in the treatment of Taste Disorders in post-COVID-19 patients	Not yet recruiting	Intervention	2022-03-07	<NULL>	<NULL>	5262	Clinical study of the application of Photobiomodulation in treatment of Dysgeusia in post-COVID-19 patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Pontifícia Universidade Católica de Campinas	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-2mfbkkk	<NULL>	Tested positive for coronavirus (COVID-19) after the Reverse Transcriptase Reaction followed by Polymerase Chain Reaction (RT-PCR) examination and who complained of symptoms of dysgeusia; Patients aged 18 years or older; Patients who are not in the disease transmission phase (fifteen days after the onset of symptoms); Patients who accept to be part of the research by signing the Free and Informed Consent Term; Patients who underwent gustatory dysfunction assessment tests and dysgeusia was confirmed	Patients who tested negative for coronavirus (COVID-19) after the Reverse Transcriptase Reaction followed by Polymerase Chain Reaction (RT-PCR) test; No complaints of dysgeusia symptoms; Under 18 years old; Pregnant and/or lactating patients; Patients who do not accept to participate in the research or who do not sign the Free and Informed Consent Form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-25dnqsk	Health economic outcomes of the medication reconciliation service in the pediatric sector of a high-complexity public hospital: A Randomized Clinical Trial	Not yet recruiting	Intervention	2022-03-07	<NULL>	<NULL>	5347	Trials on the costs of medication reconciliation in pediatrics at a high-complexity public hospital	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-03-15	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-25dnqsk	<NULL>	Patients admitted to hospital; stay in hospital for at least 24 hours; children who are from 0 days to 12 years of age and that the caregiver or guardian signs the Informed Consent Form or the Informed Assent Term	Readmitted patients; those who do not consent to participate; those who are discharged within 24 hours of admission; when counseling is not possible, as stated by the care or patient due to physical or mental restrictions, severity of illness or language restrictions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:03
RBR-446krjm	Use of Prebiotic Polydextrose in Periodontitis	Not yet recruiting	Intervention	2022-03-04	<NULL>	<NULL>	5258	Impact of Prebiotic Polydextrose as an Adjunct in the Treatment of Periodontitis and Modulation of Subgingival and Intestinal Microbiomes	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-14	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-446krjm	<NULL>	Presence of at least 15 natural teeth, excluding third molars and teeth indicated for extraction; diagnosis of generalized stage III grade A and B periodontitis, with at least 30% of the teeth with at least one site with probing depth and clinical level of insertion greater than or equal to 5 mm and bleeding on probing.	Presence of other systemic conditions which can affect the progression of periodontitis or the response to its treatment; long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and / or use of antimicrobials in the last 6 months; use of probiotics in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; extensive prosthetic rehabilitation; tobacco consumption in the last 5 years; pregnancy and lactation and gastrointestinal diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-7vd7yry	Influence of manual therapy techniques on cardiovascular modulation and cerebral circulation in healthy subjects	Data analysis completed	Intervention	2022-03-03	<NULL>	<NULL>	5254	Influence of manual therapy techniques on autonomic cardiovascular modulation and cerebral blood flow compared to placebo in young healthy subjects	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2016-07-04	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-7vd7yry	<NULL>	"voluntary participation;
understanding of the questions in the assessment;
Age greater than 18 years."	"Pain; Diseases that affect the SNA;
Changes in the ECG; Medications that affect the cardiovascular system;
Use of stimulant drinks 24 hours before."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-977fm24	The effect of laser application and desensitizing gel in the treatment of dentinal hypersensitivity	Data analysis completed	Intervention	2022-03-03	<NULL>	<NULL>	5255	Protocols for the treatment of Dentinal Hypersensitivity with Low-level Laser and Potassium Nitrate in a risk group: a longitudinal clinical study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-01	Faculdade de Odontologia  da Universidade de São Paulo	Faculdade de Odontologia  da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-977fm24	<NULL>	Both genders, aged between 18 and 45 years old; have good general health; agree to participate in accordance with the Informed Consent Form (TCLE); present at least one tooth with Hypersensitivity reported in the cervical region, which will have to have a graded sensitivity equal to or greater than 4 on the VAS scale	Present active carious lesions or with defective restorations in the tooth to be analyzed; have enough dentin loss that requires restorative treatment; having undergone any professional desensitizing treatment in the past 6 months; use of desensitizing pastes within 3 months; use of anti-inflammatory drugs or analgesics at the time of recruitment; volunteers who are pregnant or breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-5tcczr9	Effects of training consisting of different exercise modalities on functional capacity, quality of life and mental health in institutionalized elderly coronavirus survivors	Not yet recruiting	Intervention	2022-03-03	<NULL>	<NULL>	5256	Effects of multicomponent training on functional capacity, quality of life and mental health in institutionalized elderly survivors of Covid-19	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-15	Universidade Federal do Rio Grande do Sul- UFRGS	Centro Universitário da Serra Gaúcha- FSG	https://ensaiosclinicos.gov.br/rg/RBR-5tcczr9	<NULL>	Institutionalized individuals; age equal to or greater than 60 years; both genders; who had Covid-19 infection	Neurological disease; cardiovascular and respiratory changes; presence of joint or musculoskeletal injury	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-10k8j3bx	Use of multiple frequency Bioimpedance in determining the status of hydration and its impact on blood pressure control, arterial stiffness, cardiac changes, and inflammation status in peritoneal dialysis	Recruitment completed	Intervention	2022-03-03	<NULL>	<NULL>	5257	Use of Multifrequency Bioimpedance in determining the status of hydration and its impact on intermediate outcomes in peritoneal dialysis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-14	Faculdade de Medicina de Botucatu - Universidade Estadual Paulista &quot;Júlio de Mesquita Filho&quot;	"Faculdade de Medicina de Botucatu - Universidade Estadual Paulista ""Júlio de Mesquita Filho"""	https://ensaiosclinicos.gov.br/rg/RBR-10k8j3bx	<NULL>	Patients over the age of 18, on a peritoneal dialysis program for a period of three months or more, who agreed to participate by signing the informed consent form.	Cardiac pacemakers, metallic implants, amputees, malignant neoplasms, liver cirrhosis, active infectious diseases, unstable heart diseases (acute coronary syndrome, unstable arrhythmias), and severe left ventricular systolic dysfunction (ejection fraction below 30%). The interruption of follow-up will be indicated when there are adverse treatment effects that cannot be controlled by the routine dialysis procedure, such as refractory hypervolemia and arterial hypotension; acute infections, in addition to acute cardiovascular and cerebrovascular events and the express manifestation of the patient by the discontinuation of the intervention protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-8zg5rg7	Mesenchymal stromal cells for the treatment of patients with SARS-CoV-2 pneumonia	Withdrawn	Intervention	2022-03-03	<NULL>	<NULL>	6276	Multicenter phase I/IIa study of mesenchymal stromal cells for the treatment of patients with SARS-CoV-2 pneumonia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-26	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-8zg5rg7	<NULL>	Both sexes; aged 18 - 70 years old; hospitalized patients; radiological diagnosis of viral pneumonia; virological diagnosis of SARS-CoV-2 infection by PCR;  with noninvasive ventilatory support; PaO2 / FIO2 ratio between 200 and 300; C-reactive protein and ferritin above the reference value considered normal; use of corticosteroids in the dose recommended by the literature (CoDex or Recovery Protocols)	"Contraindications for use of corticosteroids; immunosuppressive and antiviral treatment; morbid obesity (BMI&gt; 35); multiple organ dysfunction syndrome; pre-malignant neoplastic conditions with life expectancy lower than 1 year old; 
pre-existing chronic illnesses like chronic dialysis kidney disease, chronic liver disease, congestive heart failure Class IV; pre-existing thromboembolic pathology; pre-existing severe allergic reaction; history of HIV and tuberculosis; enrollment in another clinical trial; pregnancy or breastfeeding"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:37
RBR-5c2qxsr	The effect of the physiotherapy technique: Hyperinflation maneuver with the Peep valve on lung compliance in children operated on for congenital heart disease	Data analysis completed	Intervention	2022-03-02	<NULL>	<NULL>	5249	Effect of Manual Hyperinsuflation Maneuver Associated with Peep valve on pulmonary compliance in post-operative of congenital cardiopathy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Jéssica Câmara Guimarães	Faculdade de Medicina de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-5c2qxsr	<NULL>	Pediatric patients of both genders will be eligible for the study; from 0 to 14 years of age; admitted to the Pediatric Intensive Care Center of the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto, University of São Paulo; in the postoperative period of cardiac surgery for correction of congenital heart disease; submitted to mechanical ventilation; with chest X-ray without signs of pneumothorax.	Exclusion criteria in the study will be patients diagnosed with metabolic and or genetic disease that course with muscle weakness and chest abnormalities; preoperative mechanical ventilation; postoperative hemodynamic instability; request of parents or guardians for the child not to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-52h647m	Effect of PRF as a complementary therapy in the treatment of periodontal disease	Not yet recruiting	Intervention	2022-03-02	<NULL>	<NULL>	5250	Effect of PRF as adjunctive therapy to scaling and root planing in the treatment of periodontitis	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia - Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-52h647m	<NULL>	Patients with Stage III Periodontitis, with 5 mm or more of interproximal attachment loss or radiographic bone loss extending to the apical half or third of the root; may have vertical bone loss of up to 3 mm; grade II or III furcation lesions and moderate ridge defect; direct evidence of non-progression of attachment loss for 5 years or indirect evidence of bone loss/year up to 0.25 mm; patients with large accumulation of biofilm but little periodontal destruction; minimum of 20 teeth present and presence of two pairs of contralateral teeth with proximal periodontal sites presenting probing depth and clinical attachment level ≥ 5 mm	Underage patients; patients who do not agree with the informed consent and do not sign it; tooth loss of 5 or more teeth due to periodontitis; positive history of antibiotic therapy in the last six months; positive history of nonsurgical periodontal therapy in the last six months; systemic involvement that may interfere with disease progression or response to treatment; need for antibiotic prophylaxis for routine dental procedures; use of anti-inflammatory drugs for a long period of time; smoking; pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-9vv26mh	Deep Transverse Massage as a Potentiating Resource in the Treatment of Patellofemoral Pain Syndrome	Not yet recruiting	Intervention	2022-03-02	<NULL>	<NULL>	5251	Effectiveness of a Protocol Involving Deep Transverse Massage in the Treatment of Patellofemoral Pain Syndrome: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-09	Ingrid Fernanda Andrade Dias	Faculdades Nova Esperança	https://ensaiosclinicos.gov.br/rg/RBR-9vv26mh	<NULL>	Adults between 20 and 40 years of age; Those with anterior or retropatellar pain in the knee; Physical activity practitioners; Presence of weakness of the muscles of the quadriceps, abductors and external hip rotators	Knee joint surgery; Presence of clinical diagnosis related to the knee (MRI findings of intra-articular pathological conditions involving ligaments or meniscal effusion, subluxation or patellar dislocation); Fracture of the patella or in the knee region; Use of anti-inflammatory drugs; Presence of comorbidities (neoplasms, obesity, neurological diseases, cardiovascular disease and respiratory diseases); Physical therapy at another service	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-9k64p2q	The effect of Low Power Laser on Pain reduction, Mouth Opening Difficulty and Swelling after wisdom teeth Removal	Not yet recruiting	Intervention	2022-03-02	<NULL>	<NULL>	5252	Evaluation of the effectiveness of the Low-powered Laser in reducing Pain, Trissum and Edema after lower third molar Extraction: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-10	Universidade Federal do Ceará - Campus Sobral (UFC)	Universidade Federal do Ceará - Campus Sobral (UFC)	https://ensaiosclinicos.gov.br/rg/RBR-9k64p2q	<NULL>	Patients older than 18 years old, who require extraction of both lower third molars; Patients who are classified by the American Society of Anesthesiology (ASA, from the English American Society of Anesthesiologists) as ASA I.	Patients with the presence of infectious conditions or pathologies associated with third molars that interfere with the clinical parameters of control of the study variables; Patients who have a chronic addiction, such as smoking or drinking; Patients who did not commit to attending at all times in this research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-8v2qmyz	Online rehabilitation of post-COVID-19 patients	Not yet recruiting	Intervention	2022-02-27	<NULL>	<NULL>	5248	Telemonitoring in the rehabilitation of post-COVID-19 patients	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Santa Catarina	Laboratório de Avaliação e Reabilitação do Aparelho Locomotor	https://ensaiosclinicos.gov.br/rg/RBR-8v2qmyz	<NULL>	Volunteers with post-covid-19 syndrome; with symptoms of fatigue; both genders; age between 18 and 70 years; no physical limitations; able to perform physical effort with grade 1, 2 and 3 classification on the modified medical research council scale;	Volunteers recovered from COVID-19 with no symptoms of fatigue; grade 4 and 5 classification on the modified medical research council scale; miss four telemonitoring sessions in total or more than two consecutive sessions; volunteers who are unable to carry out the proposed activities;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-49v75v7	Neuromuscular Eletrical Stimulation as as enhancing resource in the treatment of winged scapula: a randomized clinical trial	Recruitment completed	Intervention	2022-02-25	<NULL>	<NULL>	5242	Eficácia da estimulação elétrica neuromuscular no tratamento da discinese escapular: ensaio clínico randomizado	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-20	Faculdade De Enfermagem Nova Esperança	Centro de Saúde Nova Esperança - Unidade II	https://ensaiosclinicos.gov.br/rg/RBR-49v75v7	<NULL>	Age between 18 and 50 years; both sexes; with positive Scapular Dyskinesis Test (TDE) and who experience pain in the shoulder region  at any level of physical activity	non-intact skin or rash in the electrode area; impaired sensation; impaired cognition; ballistic movements; spastic movements; rheumatoid arthritis; osteoporosis; osteoarthritis; fever; flu-like symptoms; current; pregnancy; scoliosis; Cancer; thoracic outlet syndrome; myelopathy; diagnosis of fibromyalgia; Testing for any upper quadrant cervical or topical disease or pathology; central nervous system involvement; cervical stenosis; thoracic or cervical surgery; chronic chronicles; fracture; past or current use of corticosteroids; Patients who had a pacemaker and who are undergoing physical therapy at another service location will also be removed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-6gm4ysj	Exercise on an exercise bike associated with laser therapy on pain and quality of life in women with fibromyalgia	Recruiting	Intervention	2022-02-25	<NULL>	<NULL>	5243	Effectiveness of an aerobic exercise protocol associated with photobiomodulation with progressive dosing in the pain level and quality of life related to the health of women with fibromyalgia	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Universidade Federal de São Paulo - Campus Baixada Santista	Universidade Federal de São Paulo - Campus Baixada Santista	https://ensaiosclinicos.gov.br/rg/RBR-6gm4ysj	<NULL>	Volunteers female with aged between 18 and 60 years; with fybromialgia diagnosis according to the fybromialgia diagnostic criteria of the American College of Rheumatology 2016, evaluated by a rheumatologist doctor partner of the project; do not have deficits according to the cut-off score of the Mini Mental State Examination; classified as little active and irregularly active according to the score of the International Physical Activity Questionnaire - short version; interest and availability to participate in the entire experimental protocol	Volunteers with cognitive deficits that prevent the understanding of the assessments and questionnaires involved; who have uncontrolled systemic diseases, such as diabetes mellitus and systemic arterial hypertension; Neurological and musculoskeletal conditions that may directly interfere with assessments, such as paralysis, significant changes in sensitivity, joint diseases at advanced levels (such as arthroplasties or osteoarthritis); Continued use of alcohol or illicit drugs and absolute contraindication for phototherapy such as the presence of neoplasia; volunteers  with malnutrition (body mass index less than 18.5) or morbid obesity (body mass index equal to or above 40)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-23trp87	The implementation of a Mindfulness-based program for pediatric patients	Recruiting	Intervention	2022-02-25	<NULL>	<NULL>	5244	A Mindfulness-based program to improve the quality of life, sleep and fatigue of children and adolescents undergoing cancer treatment	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	University of Sao Paulo	University of Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-23trp87	<NULL>	pediatric patients aged 12 to 18 years old in treatment at the Institute of Children and Adolescents of Hospital das Clinicas of the University of São Paulo; caregiver consent/child assent; internet access at home; child’s self-declared state of mental stress or the will to develop coping strategies.	a confirmed psychiatric condition by the time of patients’ recruitment; the refuse to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-2bhf37x	Study of the use of biophotonics in oral mucositis	Recruitment completed	Intervention	2022-02-25	<NULL>	<NULL>	5245	Clinical study of the effectiveness of antimicrobial photodynamic therapy mediated by curcumin and low intensity laser therapy as coadjuvants in the treatment of patients with oral mucositis	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2021-09-10	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-2bhf37x	<NULL>	Patients aged 18 years or older; with stable lesions undergoing Chemotherapy and/or Radiotherapy; who agreed to participate in the research by signing the Free and Informed Consent Form	Patients who were receiving medication for the treatment and prevention of mucositis; unable to comply with the treatment procedure or with the oral hygiene protocol; who leave their group by free decision, during the research period; who modify chemotherapy or radiotherapy protocols in cancer treatment; who have worsening ulcers and, therefore, receive specific medication for mucositis; who are hospitalized due to the worsening of their oncological condition.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-48gkx3m	Analgesic effect of the use of Adjuvants in Peripheral Nerve Blocks to minimize Rebound Pain in patients undergoing Shoulder Surgery	Not yet recruiting	Intervention	2022-02-25	<NULL>	<NULL>	5247	Comparative study of the analgesic effectiveness of the uso of Adjuvantes in Peripheral Nerve Blocks to minimize Rebound Pain in patients submitted to Shoulder Surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-10	Hospital Universitário do Cajuru - Pontifícia Universidade Católica do Paraná	Hospital de Urgências de Goiânia	https://ensaiosclinicos.gov.br/rg/RBR-48gkx3m	<NULL>	Healthy volunteers; both genders; age above 18 years; physical status classified by the American Society of Anesthesia as I or II	Volunteers with neuropsychiatric disorders, cognitive impairment or mental status changes; users of monoamine oxidase inhibitors or anticonvulsants; with other fractures, injuries or previous surgery on the same operated limb; with paresis or paresthesias of the upper limb of origin different from the main diagnosis; procedures requiring a change in anesthetic technique; volunteers who refuse to participate in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-103nwkfy	Photobiomodulation for pain relief, edema reduction and perineal laceration healing in the immediate postpartum period	Recruitment completed	Intervention	2022-02-24	<NULL>	<NULL>	5241	The use of Low Power Laser in pain relief, reducing edema and screening of perineal laceration in the immediate post birth	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Secretaria Municipal de Saúde de Rio Branco	cis+ centro integrado de saude	https://ensaiosclinicos.gov.br/rg/RBR-103nwkfy	<NULL>	This study will include postpartum women of immediate vaginal birth aged 18 to 40 years, with perineal laceration I and II without suture and III, IV with episiorraphy, without clinical or obstetric complications, without associated pathologies, literate and showing good physical condition and mental.	This study excludes puerperal women undergoing vaginal delivery who have undergone episiotomy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-8tmrjvn	Effects of an exercise program associated or not with an electrical current in patients with chronic low back pain	Recruiting	Intervention	2022-02-24	<NULL>	<NULL>	7105	Effects of adding transcutaneous electrical nerve stimulation (TENS) during a walking program for individuals with chronic low back pain: blinded randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-10	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8tmrjvn	<NULL>	Individuals of both sexes, aged between 30 and 59 years, with a report of low back pain for more than 3 months, in addition to a minimum score of 3 points on the END and 37 points on the Tampa Scale of Kinesiophobia (ETC).	Regular practice in the last 6 months of any physical exercise program or sport; individuals with a history of fracture or surgical procedure in the lumbar spine; diagnosis of herniated disc with neurological repercussions; having undergone physical therapy treatment in the last month or previously with electrotherapeutic currents; use of analgesics, anti-inflammatory drugs or muscle relaxants in the last week; cancer diagnosis; pregnancy; presence of severe cardiovascular dysfunctions; medical diagnosis of fibromyalgia or other chronic pain in the lower limbs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:08
RBR-10bj7s98	Tolerated dose of Lomustine used in combination with Etoposide and Cyclophosphamide in conditioning regimen for hematopoietic stem cell transplantation in lymphoma patients	Recruiting	Intervention	2022-02-23	<NULL>	<NULL>	5240	Assessing the effectiveness and toxicity associated with conditioning protocol for autologous stem cell transplantation in lymphoma cases: Lomustine used in association with etoposide and cyclophosphamide	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10bj7s98	<NULL>	The study will include patients chemosensitive with LH and LNH younger than 60 years, who present performance status higher than 70% Karnofsky and normal cardiac function ejection fraction &gt; 50%, who do not have chronic respiratory disease expiratory volume in one second &gt; 50%, who have normal liver and kidney function, who are in partial or full disease remission, who present creatinine level lower than 2.0 mg/dL at the beginning of conditioning, and who tested negative for human immunodeficiency virus and hepatitis. All study participants will be eligible to aHSCT therefore, they will meet the criteria presented above.	Patients who do not meet the established inclusion criteria or who do not agree to participate or not sign the free and informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-4bhmm7y	CBD/THC solution as a pharmacological strategy for patients with fibromyalgia (FibroCann)	Not yet recruiting	Intervention	2022-02-23	<NULL>	<NULL>	5328	CBD/THC solution as a pharmacological strategy for patients with fibromyalgia: single-center, double-blind, randomized, placebo controlled clinical trial protocol (FibroCann)	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2022-04-15	FG Brasil LTDA	3F Clinical Trials LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4bhmm7y	<NULL>	Previous diagnosis of fibromyalgia based on the pharmacological criteria of the American College of Rheumatology, 2016 to fibromyalgia, having received three months of pharmacological treatment without relevant clinical improvement; Adult individuals (aged 18 to 75 years) with a mean pain intensity greater than or equal to 7 on the FIQ numerical pain scale (Fibromyalgia  Impact Questionnaire); No use of Cannabis or its derivatives (THC and CBD) in any systemic administration route in the last six months; Capability to read, write and speak in Portuguese (Brazil); Sign the ICF (Informed Consent Form).	Pregnancy or breastfeeding; Any known pathology, in an advanced stage, associated with the locomotor system (arthritis, osteoarthritis, uric acid); Neurological disorders; Previously reported renal disorders or changes in the exams during the pre-randomization stage; Previously reported liver disorders or changes in tests during the pre-randomization stage; Peripheral neuropathy; Known serious cardiovascular disease (uncontrolled hypertension, heart failure, cardiac pacemaker); Medical decision that participation in the study is not in the best interest of the patient; Making previous use of cannabinoids by any route of administration; Diagnosis of alcohol dependence; Usage of psychotomimetic drugs or narcotics; Having participated in research projects in the two months prior to the beginning of the study; Having a history or having first-degree relatives with a history of psychosis in any level at least once in their lifetime; Inappropriate metabolic profile of THC or CBD cannabinoids for the use of the test doses in this study, observed  by pharmacogenetic testing.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:02
RBR-427kc5t	Extracorporeal schok wave therapy on breast cancer-related lymphdema	Recruiting	Intervention	2022-02-22	<NULL>	<NULL>	5236	Extracorporeal schok wave therapy on breast cancer-related lymphdema	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Centro Universitário das Faculdades Associadas de Ensino - FAE	Carci - Indústria e Comércio de Aparelhos Cirúrgicos e Ortopédicos	https://ensaiosclinicos.gov.br/rg/RBR-427kc5t	<NULL>	Participants with secondary upper limb lymphedema after breast cancer (identified by the truncated cone formula, considered lymphedema when the difference in limb volume is greater than 200 ml); Age between 18 and 65 years; (Higher incidence of breast cancer in this age group); Female gender (higher population affected by this type of neoplasm)	Decompensated heart disease or metabolic disorders; Skin lesions such as dermatitis and dermatosis; History of deep vein thrombosis; Smokers; Participants who had electronic implants, such as cardiac pacemakers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-33ndb47	Evaluation of the humoral response to COVID-19 vaccines in Brazil	Recruiting	Observational	2022-02-22	<NULL>	<NULL>	5237	Evaluation of the humoral response to the ChAdOx1-nCov19 (AstraZeneca-Oxford/Fiocruz) and Coronavac (Butantan) vaccines against COVID-19 in Brazil: a prospective and retrospective cohort	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-02-25	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-33ndb47	<NULL>	Men and women aged 18 years and over; A resident of the metropolitan region of Rio de Janeiro or the state of Ceará; Have received at least one dose of ChAdOx1-nCov19 (AstraZeneca-Oxford /Fiocruz) or Coronavac (Butantan) vaccine in the states of Rio de Janeiro or Ceará; Accept to participate in the study by signing the Informed Consent Form.	Men and women with unavailability to comply with the follow-up schedule	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-4xcrxcm	Effects of a physical exercise treatment before hemodialysis sessions on motor skill, cognition and quality of life outcomes: a randomized clinical trial	Not yet recruiting	Intervention	2022-02-22	<NULL>	<NULL>	5238	Chronic effects of a physical exercise intervention prior to hemodialysis sessions on Motor Performance, Cognition and Quality of Life outcomes: a Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-07	Universidade Federal de Pelotas	Hospital Universitário São Francisco de Paula	https://ensaiosclinicos.gov.br/rg/RBR-4xcrxcm	<NULL>	Individuals diagnosed with chronic kidney disease on renal replacement therapy by hemodialysis; aged 50 or over; of both sexes; individuals on hemodialysis for at least three months with a minimum frequency of three times a week.	Individuals with a clinical diagnosis of musculoskeletal limitations; visual and auditory disturbances that prevent the performance of the tests; individuals with catheter in femoral or jugular vein; blood pressure equal to or greater than 220/110 mmHg or equal to or less than 100/60 mmHg; individuals who perform structured physical exercise, class III and IV angina; uncontrolled diabetics; cardiac arrhythmias; heart failure class III or more.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-5z5h789	Combined Functional Exercises with Mindfulness for improve physical and cognitive function in Older Adults with Slow Gait Speed and Cognitive Complaints	Not yet recruiting	Intervention	2022-02-22	<NULL>	<NULL>	5239	Optimizing the body-mind interaction through combining Functional Exercises and Mindfulness: effects on physical and cognitive function of Seniors with Motoric Cognitive Risk Syndrome	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Universidade de Pernambuco - UPE (Campus Petrolina)	Universidade de Pernambuco - UPE (Campus Petrolina)	https://ensaiosclinicos.gov.br/rg/RBR-5z5h789	<NULL>	We will recruit older adults, 65 years and older, with MOTORIC Cognitive Risk Syndrome	We will exclude participants who have the following criteria. not being able to speak and understand the Portuguese; not being able to walk at least 10 meters without mobility aids (eg, cane); participate in structured physical exercise programs for at least 3 months; have exacerbated walking impairment due to  musculoskeletal disorders or neurological motor deficit (eg, severe osteoarthritis, lower limb amputation, Parkinson&apos;s disease, stroke with motor sequelae); use antipsychotic-type drugs, have a diagnosis of major depression or any-type dementia;  have unstable cardiovascular or metabolic diseases (eg, angina pectoris, decompensated diabetes) or chronic complications (eg, retinopathy, neuropathy) that precludes structure exercise engagement; not having adequate visual and auditory capacity to perform the cognitive assessments	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-10y6jhrs	Effects of physical training on functional, clinical and psychosocial outcomes of adults and elderly post-infection by Covid-19	Recruitment completed	Intervention	2022-02-22	<NULL>	<NULL>	7077	Effects of physical training on functional, clinical and psychosocial outcomes of adults and elderly post-infection by Covid-19: Covid-19 and rehabilitation study (core-study)	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10y6jhrs	<NULL>	Individuals at least six weeks after hospital discharge due to COVID19; Peripheral O2 saturation (SpO2) greater than ninety percent; Normal resting electrocardiogram (twelve leads); Control of underlying diseases (under medical supervision); Ability to sit and stand without assistance; Ability to maintain balance in a standing position; Stable level of consciousness	Severe respiratory symptoms; Tracheostomy devices; Hypersecretion with ineffective coughing; Severe dyspnea; Mental confusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:07
RBR-8mj8c63	Jumps and muscle microdamages	Data analysis completed	Observational	2022-02-21	<NULL>	<NULL>	5231	Eccentric utilization rate and muscle microinjuries	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2018-10-01	Universidade Iguaçu Campus V	Universidade Iguaçu Campus V	https://ensaiosclinicos.gov.br/rg/RBR-8mj8c63	<NULL>	Be between 18 and 40 years of age; not be obese; practice more than 150 minutes of daily physical activity; Answer yes to all PAR-Q questions; do not use drugs or nutritional supplements.	Have presented osteomyoarticular lesion in the last and months; be using nutritional supplements; be an athlete in any sport; having a lower limb prosthesis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-8tkx2dp	Liquid nitrogen versus trichloroacetic acid, or their combination, in the treatment of penile warts	Recruiting	Intervention	2022-02-21	<NULL>	<NULL>	5232	Cryosurgery with liquid nitrogen versus trichloroacetic acid, or its association, in the treatment of anogenital warts on the penis: a randomized controlled trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2020-02-03	Faculdade de Medicina de Botucatu (FMB Unesp)	Faculdade de Medicina de Botucatu (FMB Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-8tkx2dp	<NULL>	Male patients with penile warts on gland, foreskin or shaft of the penis, seen at the sexually transmitted infections outpatient clinic  of the Botucatu Medical School.	Other concurrent genital dermatoses; giant condyloma acuminata, warts outside penis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-73zrnjh	Efficacy of the oral use of the drug N-acetylcysteine in the treatment of facial melasma in women	Not yet recruiting	Intervention	2022-02-21	<NULL>	<NULL>	5233	Efficacy of the use of oral N-acetylcysteine in the treatment of facial melasma in women: A randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Medicina de Botucatu (FMB - Unesp)	Faculdade de Medicina de Botucatu (FMB - Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-73zrnjh	<NULL>	Women with facial melasma 18 to 60 years old, Fitzpatrick&apos;s phototypes II to V	Patients with other concomitant facial skin diseases, skin diseases with photosensitivity, melasma with mMASI less than 5, history of hypersensitivity to the active substance oral melatonin or to any other component of the formulation described, pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-2tfxtnz	Stromal Vascular Fraction in the Treatment of COVID19 Pulmonary Diseases	Recruiting	Intervention	2022-02-21	<NULL>	<NULL>	5234	Stromal Vascular Fraction in the Treatment of SARS-Cov-2 (COVID19) Serious Respiratory Diseases	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-05	Escola Paulista de Medicina /Universidade Federal de São Paulo (EPM/Unifesp)	Associação Beneficente de Coleta de Sangue - COLSAN	https://ensaiosclinicos.gov.br/rg/RBR-2tfxtnz	<NULL>	SARS-CoV-2 (COVID-19) infection proven by reverse transcription polimerase chain reaction (RT-PCR). Age range: 18 to 80 years. Need for Mechanical Ventilation. Presentation of the critical form of COVID-19 including de following criteria: Patient with worsening of respiratory symptoms resulting in orotracheal intubation for a maximum of 96 hours; Chest radiography or tomography: Bilateral opacities - not fully explained by pleural effusions, lobar or pulmonary collapse or nodules; Origin of edema: Respiratory failure not fully explained by heart failure or volume overload; Oxygenation: partial pressure of oxygen (PaO2) divided by the fraction of inspired oxygen (FiO2) inferior to 300mmHg with positive end-expiratory pressure (PEEP) inferior to 5cm H2O. Signed informed consent by family member and / or guardian.	Pregnancy or lactation. Participation in another interventional clinical study capable of altering the patient&apos;s response to the application of vascular stromal fraction. Patients with viral infections by other etiologic agents that are not SARS-CoV-2. Other diseases affecting the respiratory tract with negative testing for COVID-19. Body mass index (BMI) under 20 and over 40 kg / m2. Presence of active malignancy (except non-melanoma skin cancer). Venous thromboembolism receiving anticoagulation currently or in the last 3 months. Patient receiving extracorporeal life support (ECMO). Patient with thrombocytopenia. Number of platelets inferior to 100,000 plaq / μL. Patients with severe chronic liver disease (Child-Pugh 12 or above). Patients in palliative care.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-9z6dw6b	Use of Cannabidiol in Patients with Chronic Heart Failure	Not yet recruiting	Intervention	2022-02-21	<NULL>	<NULL>	5235	Cannabidiol in Patients with Chronic Heart Failure: a prospective, randomized, double-blind, controlled trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-03-01	Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9z6dw6b	<NULL>	Age: 18 years to 70 years; Established documented diagnosis of Heart Failure (HF) With Reduced Left Ventricle Ejection Fraction (LVEF less than 40%), which has been present for at least 12 months; Persisted HF symptoms and low quality of life defined as: New York Heart Association (NYHA) functional class III-IV or NYHA functional class II and at least one criteria: Minnesota Living with Heart Failure Questionnaire (MLHFQ) score greater than or equal to 50 points; 6 minute walk test less than 325 metres; Elevated BNP levels; Patients should receive standard of care for heart failure with reduced ejection fraction (HFrEF) and be treated according to locally recognized guidelines	Expected surgical or percutaneous treatment for HF (coronary revascularization, valve procedure, implantation of resynchronization therapy or implantable cardioverter-defibrillator, heart transplantation, left ventricular assist device) within the next 6 months of randomization; Current acute decompensated HF or hospitalization due to decompensated HF within 30 days prior to enrolment; Acute myocarditis within 6 month prior to enrolment; HF due to restrictive cardiomyopathy, constrictive pericarditis, hypertrophic (obstructive) cardiomyopathy or uncorrected primary valvular disease; HF etiology that presents potential reversibility of the disease according to the investigators&apos; judgment; Myocardial infarction or unstable angina within 6 month prior to enrolment; Coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting) or valvular repair/replacement within 6 month prior to enrolment or planned to undergo any of these operations after randomization; Previous cardiac transplantation or implantation of a ventricular assistance device or similar device, or implantation expected after randomization; Implantation of a Cardiac resynchronization therapy (CRT) or implantable cardioverter-defibrillator (ICD) within 6 month prior to enrolment or intent to implant a CRT or ICD device; Patient in a cardiovascular rehabilitation program; Stroke or transient ischemic attack within 12 month prior to enrolment; Severe (eGFR less tha 20 mL/min/1.73 m2 by CKD-EPI), renal disease at the time of randomization; Any condition outside the cardiovascular and renal disease area, such as but not limited to malignancy, with a life expectancy of less than 2 years based on investigator’s clinical judgment; Limiting or disabling neurological or musculoskeletal conditions; Current Sars-Cov2 infection or hospital discharge for COVID-19 within the last 30 days; Post-COVID-19 syndrome defined by persistence or onset of symptoms or sequelae (eg, fatigue, chest pain, dyspnea, decreased quality of life, muscle and joint pain, anxiety, sleep disturbances, palpitations or thromboembolism) after 4 weeks of SARS-Cov2 infection, not attributed to other causes; Active malignancy; Women who have a positive pregnancy test at enrolment or randomization, or women who are breast-feeding; Use of Illicit drugs within 24 month prior to enrolment; Severe Hepatic impairment; Human immunodeficiency virus (HIV) patients; Seizures or use of anticonvulsants drugs; Schizophrenia, bipolar disorder or attempted suicide; Glaucoma; Hypersensitivity to any cannabinoid substance or contained in cannabidiol extract; Any systemic disease evaluated by the investigators that compromises the result or poses a risk to the trial; Inability of the patient, in the opinion of the investigator, to understand and/or comply with study medications, procedures and/or follow-up, or any conditions that, in the opinion of the investigator, may render the patient unable to complete the study; Participation in another clinical research protocol; Refusal to participate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-3wvbvx7	Anti-plaque effectiveness from Oil Pulling	Recruitment completed	Intervention	2022-02-18	<NULL>	<NULL>	5226	Antiplaque Efficacy Evaluation from Oil Pulling: Double-Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-13	Jéssica Gomes Alcoforado de Melo	Jéssica Gomes Alcoforado de Melo	https://ensaiosclinicos.gov.br/rg/RBR-3wvbvx7	<NULL>	"- No signs of gingival inflammation: bleeding on probing in 10% or more of the sites and probing depth ≤ 3 mm;
- Biofilm accumulation with score ≥ 1;
- Do not use orthodontic appliance or removable prosthesis;
-Have ≥ 22 teeth present in the mouth;
-Be healthy systemically.
-No allergy to coconut oil, sesame oil and chlorhexidine.
-Agree to participate in the research by signing the Informed Consent Form and having received, verbally and in writing by the researchers, all information and clarifications."	"- Had been treated with antibiotics and anti-inflammatory drugs in the last six months;
- Smokers, pregnant and lactating women;
- History of use of antimicrobial mouthwashes, gels or chewing gums in the last three months;
- History in the last few months of any dental condition that needed immediate attention (abscess, pericoronitis, edema, periodontal disease)
- Teeth with probing depth ≥ 4 mm with signs of gingival inflammation;
- Teeth with gingival retraction ≥ 2 mm."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-8wnrg48	Impact of hormone therapy on body, strength and quality of life in prostate cancer patients	Recruitment completed	Observational	2022-02-18	<NULL>	<NULL>	5227	Impact of anti-androgen therapy on body composition, strength and quality of life in prostate cancer patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-07-01	Faculdade de Medicina de São José do Rio Preto - FAMERP	Faculdade de Medicina de São José do Rio Preto - FAMERP	https://ensaiosclinicos.gov.br/rg/RBR-8wnrg48	<NULL>	Prostate cancer patients over 65 years old; Metastatic disease in sensitive castration scenario; Patients in biochemical recurrence (ASTRO definition); Intermittent hormonal blockade, with last dose of anti-androgen &gt;6 months ago	Radiotherapy or Chemotherapy in the last 30 days; Heart attack in the last 30 days; Neuromuscular disorders, hemiplegia or osteoarticular deformities of the upper/lower limbs	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-5jzcc5q	Analysis of physiological markers, physical fitness, self-esteem and self-image in elderly people undergoing adapted Taekwondo	Recruiting	Intervention	2022-02-18	<NULL>	<NULL>	5228	Analysis of physiological markers of bone remodeling, muscle strength, functional autonomy, self-esteem and self-image in elderly undergoing adapted Taekwondo	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-06	Universidade Estácio de Sá	Universidade Estácio de Sá	https://ensaiosclinicos.gov.br/rg/RBR-5jzcc5q	<NULL>	Those who have not been exercising for at least 6 months will be included	Participants will be excluded if they present any contraindication for the regular practice of physical exercise, such as osteomyoarticular, metabolic or cardiovascular injuries, those who are undergoing hormone replacement or are at high risk in the pre-exercise screening proposed by PAR-Q.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-9dr3dt7	Pressure waves and Back Pain	Not yet recruiting	Intervention	2022-02-18	<NULL>	<NULL>	5229	Shock wave and Chronic Low Back Pain	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-20	Universidade Federal de São Carlos	Universidade Federal de São Carlos	https://ensaiosclinicos.gov.br/rg/RBR-9dr3dt7	<NULL>	Low back pain for three months or more; Age 18-80 years; Low back pain with intensity equal to or greater than three on the numerical pain scale	Infection, fracture and previous surgery on the lumbar spine; Cauda equina syndrome; Pregnancy; Neuropathy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-664747m	Clinical trial to assess the rapid diagnostic test for detecting SARS-CoV-2 through breath analysis	Recruiting	Intervention	2022-02-18	<NULL>	<NULL>	5230	Multicenter, adaptive, and single-blind clinical trial to assess the predictive value of the rapid diagnostic test for detecting SARS-CoV-2 through breath analysis	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2021-11-01	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	BOH Brasil Serviços Diagnósticos Ltda	https://ensaiosclinicos.gov.br/rg/RBR-664747m	<NULL>	Both genders; Age higher or equal to 08 years completed at inclusion; Subjects to be tested for SARS-CoV-2 infection by RT-PCR or with collection of the RT-PCR test or Viral Panel and BOH within 48h between them.	Inability to fill the air bag; Persons under guardianship or deprived of liberty; Acute Obstructive Pulmonary Disease, which makes it impossible to fill the air bag.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-7hc7ty5	The occurrence of auditory and vestibular symptoms in people with fibromyalgia	Data analysis completed	Observational	2022-02-18	<NULL>	<NULL>	5253	The incidence of hearing and vestibular changes in people with fibromyalgia	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-01	Débora Pereira Fernandes	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7hc7ty5	<NULL>	People with a medical diagnosis of Fibromyalgia. Over 18 years of age. Residents of the Federative Republic of Brazil	People who denied having a medical diagnosis of fibromyalgia. People who denied having any type of auditory or vestibular symptoms. People without internet access and interest to answer the question form	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:59
RBR-63nvsq6	Effect of Laser Light alone or in conjunction with Antimicrobial Therapy in the treatment of Mouth Sores in patients with Oral and Oropharyngeal cancer	Terminated	Intervention	2022-02-18	<NULL>	<NULL>	6781	Evaluation of Photobiomodulation associated or not with Photodynamic Therapy in the treatment of Oral Mucositis in patients with Cancer of Mouth and Oropharynx - Double-Blind Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-01	Universidade Federal de Minas Gerais	Hospital do Câncer de Muriaé	https://ensaiosclinicos.gov.br/rg/RBR-63nvsq6	<NULL>	Patient underwent radiotherapy and chemotherapy with concomitant cisplatin; Patients underwent external radiotherapy with conventional fractionation (1.8 Grays day);  and received total dose of 60 Grays or more; Over 18 years old.	Patients with systemic diseases that impair wound healing (diabetes); Patients who cannot understand the research and the Free and Informed Consent Form; Patients with mouth opening difficulties prior to starting the proposed treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-8556fzp	Comparison of the accuracy of guided and conventional surgery for implant placement	Data analysis completed	Intervention	2022-02-17	<NULL>	<NULL>	5222	Guided and conventional surgery for implant placement: clinical, radiographic, microbiological, imunoenzimatic and patient-centered evaluation	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-08-06	Universidade Paulista	Universidade Santa Úrsula	https://ensaiosclinicos.gov.br/rg/RBR-8556fzp	<NULL>	Total edentulous maxillary patients; minimum bone thickness of 5.5 mm for implant placement; minimum bone height of 9 mm for placement of 6 implants.	Pregnancy; lactation; antibiotic therapy in the last 6 months, long-term use of medications that could alter osseointegration, such as anti-inflammatory drugs, bisphosphates or immunosuppressive drugs; graft needs before or during surgery; history of previous regenerative procedures in the area designated for implant installation;Patients with severe complications associated with type 2 diabetes, cardiovascular disease; peripheral vascular diseases  such as ulcers, gangrene or amputation; neuropathies; nephropathies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-86m4sns	Evaluation of the antioxidant effect of Rosmarinus officinalis in women	Recruitment completed	Intervention	2022-02-17	<NULL>	<NULL>	5224	Evaluation of the antioxidant potential of Rosmarinus officinalis in women submitted to radiofrequency	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-15	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	Universidade Regional do Noroeste do Estado do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-86m4sns	<NULL>	Women from 18 to 50 years old; localized abdominal fat; do not present comorbidities: hypertension, diabetes and autoimmune diseases; have not performed non-invasive cosmetic procedures in the last 30 days; are not on a restrictive diet.	Incapable natural person; pregnant women; breastfeeding women; use of anti-inflammatory drugs; herbal medicines; slimming products; allergy or intolerance to Rosmarinus officinalis; radiofrequency sensitivity or allergies and contraindications; obese; who have performed invasive cosmetic procedures in the last 12 months; do not accept to participate in the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-5rsrbk6	Effects of using virtual reality on children and young people with disabilities	Recruiting	Intervention	2022-02-17	<NULL>	<NULL>	5225	Effects of an intervention protocol using virtual reality in children and young people with Sensorimotor Alterations	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5rsrbk6	<NULL>	Children and young people with sensorimotor disorders; ages from 10 years old	Participants unable to understand and execute the specific instructions and commands of the intervention will be excluded; non-adaptation to the proposed intervention protocol; in case of two absences and non-attendance of the online sessions without justificatio; those who present a technical failure in the technological devices preventing the protocol from being carried out	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-8cktds4	Efficacy of techniques for feeding tube insertion in critically ill patients	Recruiting	Intervention	2022-02-17	<NULL>	<NULL>	5855	Effectiveness of techniques for insertion of nasoenteral probe in critical patients: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Cintia Galvão Queiroz	Hospital Dr. José Pedro Bezerra	https://ensaiosclinicos.gov.br/rg/RBR-8cktds4	<NULL>	Physiological or induced coma; submitted to invasive mechanical ventilation; indication of nasoenteral tube in medical prescription; over 18 years old; patients who lost the nasoenteral tube due to inadvertent exit or obstruction	Patients with coagulopathy; nasal stenosis; upper respiratory tract abnormalities; esophageal disorders; skull base fracture; teeth with mobility and history of difficult intubation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:21
RBR-3w2mxmw	Physiotherapy treatment for overactive bladder	Recruiting	Intervention	2022-02-16	<NULL>	<NULL>	5219	Parasacral transcutaneous electrical stimulation in the treatment of overactive bladder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-05-21	Universidade Federal de Juiz de Fora	Hospital Universitário da Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-3w2mxmw	<NULL>	Children with a clinical diagnosis of overactive bladder; Who have not previously undergone any treatment for overactive bladder or are at least six months without any treatment; Agreement of those responsible through the signing of the Free and Informed Consent Term (ICF); Uroflowmetry exam without alterations; Negative urine culture to exclude urinary tract infection	Children still wearing diapers; Children with neurological injuries or illnesses; Children who are using anticholinergics or tricyclic antidepressants; Children with other associated lower urinary tract disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-8wv87th	Intestinal flora, food consumption and health conditions of people with excessive accumulation of body fat and after bariatric surgery	Recruiting	Observational	2022-02-16	<NULL>	<NULL>	5220	Gut microbiota, food consumption and metabolic profile of severely obese individuals undergoing bariatric surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal do Rio de Janeiro	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-8wv87th	<NULL>	Severely obese women; in the pre and postoperative period of bariatric surgery	Men; children; adolescents; infants; pregnant women; menopausal women; the elderly; previously undergoing bariatric surgery; using prebiotics; probiotics; herbal medicines; supplements; medications such as steroids or for the purpose of weight loss and affected by other chronic diseases such as hypothyroidism; hyperthyroidism; nephropathy and inflammatory bowel disease; volunteers who do not fulfill all stages of the study will be excluded	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-10kpkctx	Evaluation of the influence of saline solution temperature on the level of pain and comfort in patients with long-term Wounds	Data analysis completed	Intervention	2022-02-16	<NULL>	<NULL>	5221	Evaluation of the influence of the saline solution temperature on the level of pain and comfort in patients with Chronic Wounds	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-09-17	Faculdade de Enfermagem da Universidade Federal de Goiás	Faculdade de Enfermagem da Universidade Federal de Goiás	https://ensaiosclinicos.gov.br/rg/RBR-10kpkctx	<NULL>	Patients over 18 years of age; both genders; with chronic wounds lasting at least 8 weeks	Individuals under the influence of psychoactive drugs; patients diagnosed with neuropathic wounds	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-9gpm9hy	The COVID-19 pandemic and the development of a device with a 3D printing technique to assit in intubating patients at the university hospital	Recruitment completed	Intervention	2022-02-15	<NULL>	<NULL>	5212	The COVID-19 pandemic and the development of a 3D videolaryngoscope for a University hospital	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Hospital Universitário Antônio Pedro - Universidade Federal Fluminense	Hospital Universitário Antônio Pedro - Universidade Federal Fluminense	https://ensaiosclinicos.gov.br/rg/RBR-9gpm9hy	<NULL>	Volunteers of all genders; over 18 years of age; with physical status classification I, II or III by the American Society of Anesthesiology; Mallampati (scale to assess the airway) I, II and III; submitted to elective surgeries under general anesthesia	Emergency surgical procedures; patients with decompensated arterial disease or hemodynamic instability; volunteers rated IV on the Mallampati scale	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-7xcjz3z	Evaluation of the effects of Foley ad Misoprostol association on the induction of labor	Recruitment completed	Intervention	2022-02-15	<NULL>	<NULL>	5213	Evaluation of the effects of Foley ad Misoprostol association on the induction of labor	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-15	Universidade Federal de Santa Catarina	Empresa Brasileira de Serviços Hospitalares (Ebserh)	https://ensaiosclinicos.gov.br/rg/RBR-7xcjz3z	<NULL>	Healthy volunteers; females; over 18 years old; pregnant women with 41 full weeks of gestation who require induction of labor; with Bishop&apos;s index less than 6.	Contraindication to the use of misoprostol. Contraindication to the use of Foley probe. Cervical dilation greater than or equal to 3 cm. Non-reassuring pre-induction cardiotocographic evaluation. Patients with high-risk pregnancies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-5gn27x8	Use of the Hammock position as a stimulus for Sleep in Pre-term newborns	Not yet recruiting	Intervention	2022-02-15	<NULL>	<NULL>	5214	Use of de Hammock position as a Sensory stimulus for Sleep in Pre-term newborns interned in a Neonatal unit	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-02-21	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-5gn27x8	<NULL>	Weight of less than 2,000g; Gestational age less than 37 weeks; More than 72 hours of life; Clinical stability.	"Neonates with neurological and/or syndromic impairments; Newborns using oxygen therapy; Newborns with injuries or fractures of bones; Neonates submitted to painful invasive procedures less than 1 hour after the study intervention;
Newborn “failed” in the ear test; Neonates using medications that may change some of the independent variables; Children awaiting surgery or transfer to another Hospital."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-29bt5qt	Acupuncture treatment of people with residual symptoms of COVID-19 infection	Recruitment completed	Intervention	2022-02-15	<NULL>	<NULL>	5215	Treatment of patients with sequelae of COVID-19 using acupuncture - a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-19	Hospital do Servidor Público Municipal	Hospital do Servidor Público Municipal	https://ensaiosclinicos.gov.br/rg/RBR-29bt5qt	<NULL>	Patients with sequelae of COVID-19 who agree to sign the free and informed consent form.	Patients with severe psychiatric problems, with surgical indication, with serious illnesses that require emergency care or with acute coronavirus disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-3qpyh3y	Effect of aqueous propolis extract on gingival tissue healing	Recruiting	Intervention	2022-02-15	<NULL>	<NULL>	5216	Evaluation of the effect of aqueous propolis extract on gingival tissue healing in smile correction surgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Jéssica Gomes Alcoforado de Melo	Jéssica Gomes Alcoforado de Melo	https://ensaiosclinicos.gov.br/rg/RBR-3qpyh3y	<NULL>	"-Have another two millimeters of gingiva band visible to the smile.
-Show gum health.
-Have an indication to perform a smile correction in the upper arch of at least canine to canine (from teeth 13, 12, 11, 21, 22 and 23).
-Be healthy systemically.
-Agree to participate in the research by signing the Informed Consent Form and having received, verbally and in writing by the researchers, all information and clarifications."	Those who, even if they present indications for correction of the smile, need some postoperative rehabilitation procedure, due to the small size of the anatomical crown, and those who are allergic to any of the drugs used in the study (chlorhexidine, aqueous extract of propolis, will be excluded from the sample). , paracetamol, 2% mepivacaine with epinephrine 1:100,000).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-6d4qyr3	Evaluation of educational actions for nurses in intensive care units about the passing of patients&apos; cases	Data analysis completed	Intervention	2022-02-15	<NULL>	<NULL>	5217	"Effectiveness of educational actions for intensive care nurses on transfer
of care"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-01	Faculdade de Enfermagem - Universidade do Estado do Rio de Janeiro	Faculdade de Enfermagem - Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6d4qyr3	<NULL>	nurses; nursing residents of the first year; nursing residents of the second year	professionals who are on sick leave, vacation or other types of leave during the data collection period	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-28x7hqf	Effects of Percussive Massage Gun massage on the physical assessment of athletes: a randomized controlled trial	Not yet recruiting	Intervention	2022-02-15	<NULL>	<NULL>	5218	Effects of the Percussive Massage Gun on clinical and biomechanical outcomes in athletes: a randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal do Ceará	Departamento de Fisioterapia da Universidade Federal do Ceará (UFC)	https://ensaiosclinicos.gov.br/rg/RBR-28x7hqf	<NULL>	Age equal to or greater than 18 years old, with at least six months of practice with weekly training frequency equal to or greater than three days, and who have not suffered musculoskeletal injuries in the last three months	Practitioners unable to perform the biomechanical tests, pregnant women, using a cardiac pacemaker, with cognitive impairment or who have undergone any surgical procedure in the last three months will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-2nwkr47	Belly time in the development of premature newborns	Recruiting	Intervention	2022-02-15	<NULL>	<NULL>	5223	Tummy time intervention in the neuromotor development of preterm newborns - randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-30	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	Departamento de Fisioterapia da Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2nwkr47	<NULL>	Participants will be selected according to the following criteria: (1) neonates born between 30 wk and 36 wk and 6 days, according to ultrasound; (2) adequate for gestational age; (3) Apgar ≥ 7 in the 5th minute; (4) birth weight less than 2500 g; (5) intrauterine growth restriction (6) absence of cardiorespiratory complications such as bronchopulmonary dysplasia and congenital heart diseases, neurological such as brain malformation, microcephaly, hydrocephalus, musculoskeletal disorders such as congenital clubfoot and congenital muscular torticollis, or auditory according to the little ear test; genetic syndromes, congenital infections (toxoplasmosis, syphilis, rubella, cytomegalovirus and herpes simplex) and visual changes according to the little eye test; (7) present poor or normal motor repertoire in the assessment of Generalized Movements (MG).	The following will be excluded: (1) babies diagnosed with grade III and IV intraventricular hemorrhage; (2) babies whose parents withdraw from participating (3) babies who do not attend 2 assessments to monitor primary and secondary outcomes, (4) parents do not answer the phone for 3 consecutive days to reschedule assessments or declare withdrawal from the intervention by of the guardians, (5) parents who do not fill out the field diary to monitor the practice of Tummy Time. After randomization, participants will be excluded if they present any health deterioration and need to be hospitalized, change state and/or country.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:58
RBR-3tdk22p	"Evaluation of healing after tooth extraction in patients with
head and neck cancer"	Recruiting	Intervention	2022-02-14	<NULL>	<NULL>	5208	"Evaluation of the healing process in alveolus of patients diagnosed with
head and neck cancer"	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Faculdade de Odontologia da Universidade Federal de Uberlândia	Faculdade de Odontologia da Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-3tdk22p	<NULL>	Patients diagnosed with head and neck cancer; both genders; age above 18 years; with indication and need for dental extraction either in the pre-radiotherapy or post-radiotherapy phase and who provide consent to participate in this research project by signing the Free and Informed Consent Form	Underage patients, patients who do not agree with the Free and Informed Consent Form; patients with advanced tumors who, due to the urgency of starting radiotherapy, do not have enough time to perform tooth extractions; patients with health changes that contraindicate surgical extraction procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-79sm4vd	Analgesia after dental implant surgeries	Not yet recruiting	Intervention	2022-02-14	<NULL>	<NULL>	5210	Postoperative analgesia in Implant Dentistry	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-79sm4vd	<NULL>	Adult patients (aged 18 years or older), of both sexes, who need surgery to install at least 3 dental implants or dental implant protocols, with the objective of prosthetic rehabilitation will be included.	"Individuals will be excluded:
- who present a previous picture of chronic or acute pain, related or not to the oral cavity,
- in chronic or acute systemic use (in the 48 hours prior to the procedure) of analgesic, anti-inflammatory and/or muscle relaxant,
- with difficulty in understanding instructions (cognitive changes), which impair the application of the scales proposed by the study, such as illiterate patients, with inability to numerically notate and write the pain parameters proposed by the study,
- with contraindication for the use of ibuprofen,
- with contraindication for the use of paracetamol associated with codeine."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-2h3wqrj	Prostatic Artery Embolization vs Open Prostatectomy: a comparative study between two different methods for the treatment of Prostate Enlargement.	Recruitment completed	Intervention	2022-02-14	<NULL>	<NULL>	5211	Prostatic Artery Embolization vs Open Prostatectomy: comparative analysis in patients with LUTS secondary to BPH and prostates&gt; 80ml	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-13	Disciplina de Urologia da Escola Paulista de Medicina da Universidade Federal de São Paulo	Disciplina de Urologia da Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2h3wqrj	<NULL>	"Over 40 years
Moderate/severe LUTS due to large-volume BPH (&gt;80 mL)
IPSS greater than or equal to 8
Quality of life greater than or equal to 3
Urodynamic showing obstruction"	"Severe atherosclerosis
Severe tortuosity in aortic bifurcation
Neurogenic dysfunction
Urethral stenosis
Bladder diverticulum
Bladder stone
Underactive bladder
Creatinine clearance &lt;60ml.min
Prostate cancer"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-7t8vqrz	Effects of Aerobic Exercise with and without Cognitive Tasks on Gait control, Balance, Acetylcholine neurotransmitter Activity, activity of front part of the Brain and Symptoms of people with Parkinson´s disease	Recruiting	Intervention	2022-02-14	<NULL>	<NULL>	5526	Effects of Resistance Training with and without Cognitive tasks on the Automaticity of Gait, Postural Instability, Cholinergic Activity, prefrontal cortex activity and Motor Symptoms Severity of individuals with Parkinson´s disease: A randomized double Blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-15	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7t8vqrz	<NULL>	Parkinson´s disease severity at II-III stage according to the modified Hoen Yahr scale; Age between 50 and 85 years old; Global cognition with a score greater than 21 for individuals with schooling between 4 and 12 years, and greater than 20 for individuals with more than 12 years of schooling, according to the Monttreal Cognitive Assessment (MoCa), portuguese version; and being a faller (i.e., more than 2 falls in the last 6 months)	Not have had training in the last 6 months; No othe neurological disorder (beyond idiopathic Parkinson´s disease; Do not use AChE inhibitors (e.g., rivastigmine, donepezil, galantamine and tacrine), benzodiazepine, neuroleptic or tricyclic antidepressants; Not having resting tremor with a score greater than 2 (i.e., excessive tremor); and not present Freezing of Gait	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-2fcsnhq	Quality of post-surgical healing in patients with Dupuytren&apos;s Disease	Recruitment completed	Intervention	2022-02-14	<NULL>	<NULL>	5567	Randomized clinical trial on healing after incisional fasciectomy Bruner and McCash in patients with Dupuytren&apos;s Disease	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-15	Luiz Guilherme de Saboya Lenzi	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2fcsnhq	<NULL>	Patients with a previous diagnosis of Dupuytren&apos;s disease, indication for surgical treatment, both sexes, older than 40 years, who agree to participate in the research, prior signature of the free and informed consent form	Patients under 40 years of age, without clinical conditions to undergo surgical treatment, presence of previous trauma to the hand and wrist that will undergo surgical treatment, previous hand and wrist surgery that will undergo surgical treatment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-96xv826	The contribution of the Anterior Lumbar Quadrate Block in the reduction of pain, in the recovery of lung function in patients undergoing laparoscopic cholecystectomies	Recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5198	Effect of Anterior Lumbar Quadrattus Block on analgesia and recovery of respiratory muscle strength in the postoperative period of videolaparoscopic cholecystectomies	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-09-20	Universidade Federal do Estado do Rio de Janeiro	Universidade Federal do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-96xv826	<NULL>	18 to 75 years old, scheduled for laparoscopic cholecystectomy at Hospital Universitário Gaffre e Guinle	Patients will be excluded from randomization if they refuse to participate in the study; presence of peripheral neuropathies, coagulopathies or hypersensitivity to drugs used for analgesia; infection at the puncture site; deformities or previous spinal operations; dementia or other states that prevented an adequate understanding of the use of the numerical-verbal pain scale (ENV); diseases of immunological characteristics, diabetes mellitus, malignant neoplasm, use of opioids or anti-inflammatory drugs in the preoperative period; and those whose surgeries require conversion to a conventional technique (open surgery). The presence of pain at the surgical incision site that may prevent deep inspiration, as well as the need for other surgical interventions during the study and a BMI greater than 35, will also be considered as exclusion criteria.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-5n53cnv	Effects of Physical Exercise on post-discharge patients by Covid-19	Recruitment completed	Intervention	2022-02-11	<NULL>	<NULL>	5199	Physiological and sensory effects of Cardiopulmonary Rehabilitation based on Physical Exercises in patients post hospital discharge by Covid-19	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-12-01	Hospital Militar de Área de São Paulo	Hospital Militar de Área de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5n53cnv	<NULL>	Patients after hospital discharge, with a discharge period of ≤ 6 months; infected with COVID-19 confirmed by a molecular test RT-PCR for diagnosis of the SARS-COV-2 virus; of both sexes; aged between 20 and 85 years old and who agree to participate in the research, signing the free and informed consent form.	Patients with ventricular arrhythmias; atrial fibrillation; unstable angina; acute myocardial infarction; with worsening of respiratory symptoms such as dyspnea and worsening of the aspect and or increased volume of bronchial secretion. Patients with musculoskeletal and or neurological alterations that make it impossible to perform tests and physical exercises will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-22xkyk5	Functional performance in modified Constraint-Induced Therapy in real and virtual environments in stroke patients	Recruitment completed	Intervention	2022-02-11	<NULL>	<NULL>	5200	Functional performance in modified Constraint-Induced Therapy in environments real and virtual in patients with cerebrovascular accident: Follow up	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Escola de Artes Ciências e Humanidade  - USP	Escola de Artes Ciências e Humanidade  - USP	https://ensaiosclinicos.gov.br/rg/RBR-22xkyk5	<NULL>	Have a diagnosis of ischemic stroke for more than 1 year; have a range of motion of active wrist extension of 20º and active finger extension of 10º; age over 18 years; understand the task; absence of surgery	Presence of associated diseases that could interfere in the sample, such as Parkinson&apos;s and Alzheimer&apos;s; patients with severe aphasia and visual and / or hearing disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-7xnnb4z	Effectiveness of periodontal treatments in obese and diabetic individuals	Not yet recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5201	Evaluation of different treatments for periodontal diseease in obese and diabetic individuals - Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Thayná Nathally Petry de Paula	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7xnnb4z	<NULL>	As inclusion criteria, patients will be of both sexes, with diabetes mellitus II (Glycated hemoglobin greather or equal to 7% at the last medical check-up) and stage II or III Grade C periodontitis; with at least 4 sites with probing depth above 5mm and level of clinical attachment greater than or equal to 4mm, not on the same tooth, with bleeding on probing and gingival inflammation, free of caries and/or prostheses on clinical examination; All patients must have at least 12 teeth present, excluding third molars and teeth suitable for extraction	As exclusion criteria, patients must present a positive history in the last six months of antibiotic therapy, steroid or non-steroidal anti-inflammatory drugs, anticoagulants and immunosuppressants in the three months preceding the study; positive history of pregnancy or breastfeeding; positive history of use of contraceptives or any other form of hormone; positive history of smoking or permanent cessation of the habit for at least 5 years; positive history of periodontal treatment in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-2fzkjtx	Effectiveness of a training program aimed at medical residents in oncology to help manage cancer pain in a referral hospital	Not yet recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5202	Implementation of a training program directed to oncology resident physicians to support cancer pain management in a reference hospital	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Hospital de Câncer de Barretos	Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-2fzkjtx	<NULL>	First-year residents in clinical, surgical, radiotherapy and hematology oncology	First-year residents who do not wish to participate in the survey	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-9bxptps	The effect of caffeine on Chronic Fatigue Syndrome caused by COVID-19	Recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5203	The effect of caffeine on Chronic Fatigue Syndrome caused by COVID-19	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-15	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-9bxptps	<NULL>	Have been diagnosed with COVID-19 in the previous period of at least 6 months;Be identified with Chronic Fatigue Syndrome through the International Consensus Criteria; be able to perform physical exercise based on the Physical Activity Readiness Questionnaire (PAR-Q); adult patients (aged 18 years or older); be a consumer of low to moderate amounts of caffeine (200-400mg daily); be literate	Results on the Electrocardiogram that identify incompatibility with the performance of physical exercises; musculoskeletal pathologies that prevent participation; moderate to severe cardiovascular disorders; convulsive history;Gastric problems;Use of nutritional supplements or ergogenic aids; structural or functional deformities;Ischemic or hemorrhagic stroke; arterial hypertension; neurodegenerative diseases; cognitive problems; visual disturbances without treatment; gestation; use of oral contraceptives; color blindness; smoking; use tricyclic antidepressants; use of medications containing caffeine	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-289z7vn	Oral or intravenous Tranexamic Acid for visual improvement during surgery in patients undergoing repair of shoulder tendon tears	Recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5204	Oral or intravenous tranexamic acid to improve visual clarity in the intraoperative period of patients undergoing arthroscopic repair of rotator cuff tears in the shoulder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Universidade Federal do Maranhão	Universidade Federal do Maranhão	https://ensaiosclinicos.gov.br/rg/RBR-289z7vn	<NULL>	Both genders; 18 years or older; diagnosis of rotator cuff tear and failure of conservative treatment for more than 3 months.	Modified Coagulation test; kidney disorder; liver disorder; uncontrolled hypertension, considering systolic pressure greater than 180 mmHg; allergic to anesthetic agents or tranexamic acid.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-10xjp5tz	Assessment of maxillary bones through imaging tests after treatment with a device to increase the width of the maxilla compared to surgical treatment in adults.	Recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5205	Three-dimensional evaluation of biological effects on the craniofacial complex of surgically assisted rapid maxillary expansion (SARME) and mini-implants (MARPE) in adults	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Faculdade de Odontologia Universidade de São Paulo	Hospital Universitário da da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10xjp5tz	<NULL>	Brazilian nationality; Craniofacial growth completed; Transverse maxillary deficiency, with or without posterior crossbite, unilateral or bilateral; Age between 25 and 45 years old, male and female; permanent dentition, with at least the first or second permanent upper molars; Good dental conditions and periodontal health. No history of previous orthodontic treatment; Absence of systemic diseases or congenital deformities. Transverse maxillary discrepancy greater than 4mm and less than 10mm	Absence of permanent maxillary first molars and pre- molars. Presence of deformities or congenital syndromes; Presence of cleft lip and palate; Presence of systemic diseases	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-5x7ccxp	Evaluation of the effect of an antiretroviral drug in patients infected with HTLV-1.	Recruiting	Intervention	2022-02-11	<NULL>	<NULL>	5206	Evaluation of the effectiveness of Dolutegravir in HTLV-1 infection: a pilot, open, randomized and controlled study.	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2021-07-22	Fundação Bahiana de Infectologia - FBAL	Programa de Pós-graduação em Medicina e Saúde - Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5x7ccxp	<NULL>	Volunteers aged over 18 years, of both genders, have been diagnosed (by Western blot  or PCR) with HTLV-1; not present neurological or cognitive deficits that interfere in the performance of any of the proposed activities.	Subjects with current HIV, HCV (RNA positive) and HBV (HBsAg positive) infection; Active tuberculosis; Corticosteroid use in the last 30 days; End-stage renal  disease (hemodialysis); Cancer; Autoimmune diseases; Wheelchair restricted individuals; Subjects who voluntarily request withdrawal from the study; that do not adapt to the proposed protocols.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-9x99fg8	Assessment of the degree of muscle injury and impairment of strength and movement in Knee Replacement Surgery using a pneumatic tourniquet in an optimized way	Data analysis completed	Intervention	2022-02-11	<NULL>	<NULL>	5207	Assessment of the degree of muscle injury and impairment of quadriceps motor function with the use of an optimized tourniquet in Total  Knee Arthroplasty	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-08-01	Instituto Nacional de Traumatologia e Ortopedia INTO	Instituto Nacional de Traumatologia e Ortopedia INTO	https://ensaiosclinicos.gov.br/rg/RBR-9x99fg8	<NULL>	The study will include patients with knee osteoarthritis glued to the cemented TKA and who agreed to participate in the research by signing the Informed Consent Form (ICF).	Patients with uncontrolled sitemic arterial hypertension and chronic heart disease, smokers, patients with a history of previous surgery on the same joint, patients with evidence of joint infection, patients with congenital or acquired coagulopathies, patients on chronic use of oral and anticoagulants will be excluded from the study.  corticosteroids, patients with malignant neoplasms and autoimmune diseases, patients with indication for revision surgery and patients with severe axis deviation of the lower limbs (varus&gt; 10 ° and varus&gt; 15 °).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:57
RBR-5tvjs5t	Comparison of the effect of intense interval exercise with moderate interval training on physical capacity and quality of life in patients with post covid -19 syndrome: a comparative study	Recruitment completed	Intervention	2022-02-11	<NULL>	<NULL>	7655	Training effect of high intensity interval training versus moderate intensity continuous training in functionality and life of quality of post-covid19 syndrome patients: a randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-5tvjs5t	<NULL>	Patients of both sexes; aged from eighteen to sixty-five years old; with post covid syndrome19; with previous diagnosis of SARS CoV 2 infection by positive reverve transcription polymerase chain reaction for SARS-CoV-2 in combined nasopharyngeal swab molecular test examination of nasal and pharyngeal swab specimens or diagnosis according to computed tomography evidence from at least four weeks prior to admission to the post covid center; medical clearance to exercise	Orthopedic, neurological, or muscular limitations that prevent the adequate performance of physical exercise; Report of angina or previous coronary disease; Uncontrolled hypertension; Heart failure; Previous uncompensated pulmonary disease; Significant aortic stenosis; Active pericarditis or myocarditis; Uncontrolled atrial or ventricular arrhythmias; Third degree atrioventricular (AV) block without pacemaker; Patients who have had radiotherapy and/or chemotherapy in the last 6 months; Signs of embolism or acute thrombophlebitis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:28
RBR-2ssyb6q	Usability, acceptability and feasibility of a digital intervention to promote healthy lifestyle: a pilot study	Not yet recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5194	Usability, acceptability and feasibility of a digital intervention to promote healthy lifestyle: a pilot study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-15	Instituto de Comunicação e Informação Científica e Tecnológica em Saúde	Instituto de Comunicação e Informação Científica e Tecnológica em Saúde	https://ensaiosclinicos.gov.br/rg/RBR-2ssyb6q	<NULL>	Men and women ; who live in Rio de Janeiro (RJ) ;  18 years or over; Unified Health System (SUS) users; have a personal computer or smartphone;  have a data plan for internet access; agree to participate in the study	restrictions or clinical conditions that contraindicate the practice of physical exercise; use of diets prescribed by health professionals due to clinical conditions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-7q4ymr2	Validation of a computer program for the identification of false information related to fluoride consumption among Internet users	Recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5195	Validation of a neural network model for detection of disinformation related to fluoride consumption through the psychophysiological reactions of Internet users	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Faculdade de Odontologia de Bauru da Universidade de São Paulo	Faculdade de Odontologia de Bauru da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7q4ymr2	<NULL>	Volunteers who are parents or guardians of children treated at the clinics of the Bauru School of Dentistry, University of São Paulo; native Brazilians; literate; who have access to the Internet at home	Not applicable	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-10rnr53n	Increase in Hand Strength and Through the Influence of Contralateral Index Finger Strength in Individuals with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5196	Increased Palmar Grip Strength and Overflow-Induced Hand Speed Contralateral to Isometric Contraction of the Index Finger in Individuals with Parkinson&apos;s	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-06-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10rnr53n	<NULL>	Volunteers with a diagnosis of Parkinson&apos;s Disease; both genders; aged between 18 and 70 years; who can understand the requested activity; who agreed to participate in the study voluntarily.	Individuals with another associated neurological disease; individuals with dementia; individuals with an upper limb or part of it amputated; individuals with associated cognitive alterations.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-2jws7dv	Effect of an Educational Technology about sex transmitted Infections for women deprived of liberty	Not yet recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5197	Educational Technology on Sexually Transmitted Infections for incarcerated women: clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-2jws7dv	<NULL>	Incarcerated women, regularly enrolled at the Olga Benário Prestes State School that operates within the chosen prison unit and with a minimum stay of 2 months.	Women who were not authorized by the prison unit or school administration for conduct that represents a risk for those involved; and pregnant women, for presenting information about STIs during prenatal consultations, which can be considered a bia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-46kpjkm	Momentary and long-term effects of different walking intensities on the psychological elements of the elderly	Not yet recruiting	Intervention	2022-02-10	<NULL>	<NULL>	5366	Acute and chronic effects of different intensities of aerobic exercise on the psychological aspects of the elderly	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-04	Programa de Pós Graduação em Ciências da Saúde da Universidade Comunitária da Região de Chapecó	Programa de Pós Graduação em Ciências da Saúde da Universidade Comunitária da Região de Chapecó	https://ensaiosclinicos.gov.br/rg/RBR-46kpjkm	<NULL>	Elderly people in the city of Chapecó aged over 60 years. Classified as insufficiently active by the reduced IPAQ version VIII. Who have a minimum score on the Mini-Mental State Examination (MMSE). Until reaching the number of elderly people resulting from the sample calculation plus loss estimate	Participants who do not have a minimum frequency of 75% in the program.  Who have changes in levels of physical activity during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:04
RBR-27dc264	Preventive intervention in body image disturbances, Eating Disorder and Body Dysmorphia of young adult Men	Recruitment completed	Intervention	2022-01-31	<NULL>	<NULL>	5189	Preventive intervention in body Image disturbances, Eating Disorder and Body Dysmorphia in young adults: a randomized controlled trial in Brazilian Men	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-04	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-27dc264	<NULL>	Men, university students, age between 18 and 30 years. Any color, race or ethnicity. Be regularly enrolled in the Federal University of Juiz de Fora (UFJF) campus Governador Valadares - MG. Accept participate voluntarily in the study.	Have any mental disorder, eating disorder or muscle dysmorphia. Request the termination of your participation through an express, free and clarified statement. Expressly request not to use your data.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-7sxfdpt	Neuromodulation associated with virtual reality for the treatment of migraine.	Recruiting	Intervention	2022-01-31	<NULL>	<NULL>	5190	Transcranial Electrostimulation by Current Continuous associated with Virtual Reality in the Treatment of Migraine - Randomized Clincal Trial Explanatory	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal do Rio Grande do Sul	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-7sxfdpt	<NULL>	"female individuals, aged between 18 and 50
years with migraine without aura, who have at least 15 days of pain from
headache per month, of which at least 08 migraine attacks as per
International Headache Society criteria - ICHD-3 (IHS, 2013)."	"history of neurological, psychiatric, or medical illness
acute; family history of epilepsy; pregnancy or lactation; cardiac pacemaker; bad
cranial formation; previous surgery involving head implants; presence of
vestibulopathies (labyrinthitis, dizziness, vertigo); any system treatment
central nervous system by peripheral neurostimulation prior to research."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-96wctgg	Development of a standardized protocol of neurological manifestations in patients with SARS-CoV-2	Recruiting	Intervention	2022-01-31	<NULL>	<NULL>	5191	Development of a standardized protocol of neurological manifestations in patients with SARS-CoV-2	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-05	Universidade Federal do Triângulo Mineiro	Universidade Federal do Triângulo Mineiro	https://ensaiosclinicos.gov.br/rg/RBR-96wctgg	<NULL>	Individuals over 18 years of age in the acute and subacute phase of COVID-19; functional status between 0 to 2; schooling over 9 years (complete high school); who can independently respond to the test	Individuals who do not adhere to the intervention protocol with one or more absences; who have some type of motor or cognitive impairment during the study period; who present clinical instability during the intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-7tqy7yw	Light Therapy for Pain control after Root Canal Treatment	Recruiting	Intervention	2022-01-31	<NULL>	<NULL>	5192	Evaluation of Photobiomodulation Therapy and Photodynamic Therapy in Postoperative Pain after Endodontic Treatment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-02-02	Monique de Carvalho Souza	Sergio Luiz Pinheiro	https://ensaiosclinicos.gov.br/rg/RBR-7tqy7yw	<NULL>	"-Patients responding to symptomatic irreversible pulpitis (by
through pulp sensitivity tests) and who are not using
medication such as: antibiotics, anti-inflammatory drugs, analgesics or immunosuppressants;
- Multirooted mandibular molars; it can be first or second molar,
mesial canals of moderate curvature between 10° and 20° (15);
- Dental crown in favorable conditions for the use of insulation
absolute;
- Roots and foramina fully formed;
- Absence of apical internal/external resorptions, absence of lacerations,
absence of calcifications of the canals (confirmed through radiographs)."	"- Children, pregnant or breastfeeding;
- Teeth with advanced periodontal disease, evaluated through clinical examination
and radiographic (periodontal pocket over 3 mm, bone loss);
- Teeth that are not treated in a single session;
- Teeth that obtain an extrusion of filling material, evaluated through
of radiographic examination;
- Patients who use medication after endodontic treatment."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-4s8qyyq	"Use of mobile phone application (App) to promote healthy salt consumption: intervention in
adults"	Recruiting	Intervention	2022-01-28	<NULL>	<NULL>	5183	"Use of mobile phone application to promote healthy salt consumption: intervention in
adults"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Estadual de Campinas	Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4s8qyyq	<NULL>	Have between 20 and 59 years old; have access to a mobile phone that supports the mobile App; speak Portuguese; consent to participate to the study.	People who are receiving nutritional guidance from a health professional will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-2hdrph7	Osteopathic treatment in individuals with Anxiety and the effects over the Autonomic nervous system - A randomized clinical trial	Not yet recruiting	Intervention	2022-01-28	<NULL>	<NULL>	5184	Osteopathic manipulative treatment in individuals with Anxiety disorders symptoms and the effects over the ANS - A randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-13	Escola de Osteopatia de Madrid - Brasil	Escola de Osteopatia de Madrid - Brasil	https://ensaiosclinicos.gov.br/rg/RBR-2hdrph7	<NULL>	"Women who meet the mild and moderate symptoms of the Hamilton Anxiety Scale will be included;
It has an age range between 18 and 55 years old;
Agree to the Informed Consent Form (FICF) in accordance with Appendix A."	"Patients with a HAM-A score equal to or above 30 will be excluded;
Present other psychiatric or cognitive disorders;
Inability to complete the questionnaires;
Associated serious pathologies (such as cancer or severe heart disease);
Pregnant women;
Being addicted to alcohol or drugs;
Not being 18 years old before the beginning of the evaluations;
Have completed 56 years or older by the end of the assessments;
Use anxiolytic medications during the study period or in the last 6 months;
Have undergone manual osteopathic treatment in the last 3 months;
If you are absent from any stage of the research protocol;
Present any suspicious symptoms (fever, cough, runny nose, difficulty breathing, excessive tiredness, loss of smell or taste) and/or diagnosis of Covid 19;
Not using or refusing to wear a personal protective mask."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-4brjtqz	Analysis of heart rate variability and effort in children and young people with Down syndrome in the use of virtual games for home telerehabilitation	Recruitment completed	Intervention	2022-01-28	<NULL>	<NULL>	5185	Analysis of heart rate variability and perception of physical effort in children and young people with Down Syndrome submitted to virtual games protocol by home telerehabilitation	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-04	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4brjtqz	<NULL>	Participants were included if they were children and adults with DS aged 10 to 30 years old; agreed to participate in the research from themselves (by signing assent form ) and their legal guardians (by signing a consent form).	Participants were excluded if they were unable to understand and execute the specific guidelines and commands of the intervention; did not adapted to the proposed intervention protocol; or those that presented technical failure in the technological devices preventing the realization of the protocol. Children and young adults who presented low vision or blindness, vestibular pathologies and those who did not had technological devices to perform telerehabilitation were not included in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-10jksk74	Evaluation of biomarkers and gene expression profile related to peripheral microvascular reserve in patients with severe infections	Recruiting	Observational	2022-01-28	<NULL>	<NULL>	5186	Evaluation of biomarkers and gene expression profile related to peripheral microvascular reserve in septic patients	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-10-01	Hospital de Clínicas - Universidade Federal do paraná	Instituto Carlos Chagas - Fiocruz	https://ensaiosclinicos.gov.br/rg/RBR-10jksk74	<NULL>	Adult patients; age above 18 years; diagnosed with sepsis; admitted to the Intensive Care Units	Pregnancy; refusal to participate in the study; exclusion of the sepsis diagnosis after data collection; diagnosis of acute SARS-COV2 (COVID-19) infection	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-83yyrg5	Systematization of surgical leg reconstruction	Recruitment completed	Intervention	2022-01-28	<NULL>	<NULL>	5187	Systematization of the reconstruction of skin loss in the leg	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-11-24	Fundação Arnaldo Vieira de Carvalho	Hospital Universitário Lauro Wanderley/Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-83yyrg5	<NULL>	Presenting a lesion in the leg, with exposed bone fracture or not; be 18 years of age or older; not having any other comorbidity that prevents the application of the reconstruction methods proposed in this study; have favorable clinical conditions for the procedure; remain in follow-up for at least 6 months	Cases in need of microsurgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-7gcggcm	Influence of compensating curves on the masticatory performance and swallowing threshold of complete denture wearers: Randomized clinical trial	Data analysis completed	Intervention	2022-01-28	<NULL>	<NULL>	5188	Influence of compensating curve on the masticatory function of complete denture wearers (Randomized clinical trial)	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2019-02-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-7gcggcm	<NULL>	Totally edentulous in the upper and lower arches; age between 40 and 70 years; good general health; having alveolar ridges classified as horizontal or distal ascending in the mesio-distal direction; and normal in the buccolingual direction, with mandibular-symphysis bone height grater than 16 mm	Presence of clinically detected parafunctional habits; history of symptoms in the temporomandibular joints and masticatory muscles; have osteoporosis; having Type I and II Diabetes Mellitus; to be a smoker; apparent xerostomia; patients with uncontrolled systemic diseases; individuals who underwent radiotherapy in the head and neck	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-10fg77vk	Effects of cupping therapy on pain intensity, fatigue and performance after a 10km run	Not yet recruiting	Intervention	2022-01-28	<NULL>	<NULL>	6197	Effects of sliding cupping therapy on pain intensity, fatigue perception and muscular performance after a 10km run	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-07-05	Universidade Federal do Rio Grande do Norte - Faculdade de Ciências da Saúde do Trairí	Caio Alano de Almeida Lins	https://ensaiosclinicos.gov.br/rg/RBR-10fg77vk	<NULL>	"Street runners for at least 1 year who run twice a
week; Being able to run 10 km continuously in the time interval between 40 and 60 minutes in at least one training session; Be between 18 and 45 years old; Not present severe cardiorespiratory or metabolic alterations, proven by a medical report; Not reporting the presence of musculoskeletal disorders in the lower limbs, in the last 6 months, that have prevented the maintenance of the training routine; Do not report any of the contraindications for the application of cupping therapy; Never having used cupping therapy"	"Presenting disorders in the quadriceps femoris, such as hematoma and cramp, during
study procedures; Present allergy or skin irritation due to the use of vegetable oil necessary for cupping therapy; Not being able to complete the 10km run within 60 minutes; Failure to correctly perform the assessment procedures; Not attending any stages of collection development; Make use of anti-inflammatory drugs, corticosteroids, analgesics or muscle relaxants during the collection period or in the 30 days preceding the beginning of the study; Make use of ergogenic resources, such as anabolic steroids, in the last 6 months prior to the start of collection; Carry out another type of intervention for muscle recovery during the development of the research; Refusing to sign the Free and Informed Consent Form (ICF)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:34
RBR-8g6f2rv	Plants use in the management of viral respiratory infections, as in COVID-19	Recruitment completed	Intervention	2022-01-27	<NULL>	<NULL>	5174	Ethnopharmacological strategy in the management of viral respiratory infections, as in COVID-19	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-27	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8g6f2rv	<NULL>	Older than 18 years;  suspected coronavirus infection	Hospital internment; intolerance to the tested compounds; unwillingness to use teas daily; pregnant women or women of reproductive age who do not use hormonal contraceptives.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-9n9yq4p	Effect of acute caffeine intake on rating of perceived exertion, muscle pain and fatigue during exercise in women with fibromyalgia	Not yet recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5175	Effect of acute caffeine intake on perceptive responses, muscle oxygenation and neuromuscular fatigue development during exercise in women with fibromyalgia	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-9n9yq4p	<NULL>	Volunteers with an age between 30 and 60 years; be classified as sedentary or insufficiently active according to the  international physical activity questionnaire; clinical diagnosis of fibromyalgia according to the American College of Rheumatology criteria	tobacco usage; any kind of bone or muscle injury that prevent to perform the exercise tests; any restriction related to caffeine intake or physical exercise practice	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-45hth2d	.Effect of resistance training to improve physical capacity in people with chronic low back pain	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5176	Influence of a resistance training program for people with chronic low back pain on parameters associated with functional disability, pain and neuromuscular activation	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Faculdade de Educação Física da ACM de Sorocaba	Faculdade de Educação Física da ACM de Sorocaba	https://ensaiosclinicos.gov.br/rg/RBR-45hth2d	<NULL>	Time of low back pain between three and twelve months; episodes of pain at least twice a week; pain scale not exceeding five points; oswestry desability between twenty one and forty; no pain below the knee; not having a positive test for radicular pain in the lower limbs; agree not to use medications or pain relievers during the study; not participating in any exercise program for at least three months; men or women aged between twenty and fifty nine years; absence of spinal surgery, herniated disc or severe scoliosis; body mass index less than thirty; present an image exam of orthostatic or resonance radiography; not being involved in labor proceedings.	Participation in less than seventy five percent of training sessions; impossibility to carry out the final evaluation; use any medication or pain relievers during the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-2zky4p9	Comfort and safety of an adapted mask versus an orofacial mask in postoperative heart surgery patients	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5177	Comfort and safety of the owner mask in relation to the conventional orofacial mask in post-operative heart surgery patients: a pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-03	Universidade de Santa Cruz do Sul	Hospital Santa Cruz	https://ensaiosclinicos.gov.br/rg/RBR-2zky4p9	<NULL>	"Patients admitted to the ICU for post-operative care after CABG or TV from May to October 2021.
Patients of both sexes.
Age between 18 and 80 years.
Indication of institution of non-invasive ventilation after extubation.
Preserved cognitive ability to understand the proposed tests."	"Comatose patients (Glasgow Coma Scale &lt;8).
Patients who refuse to receive non-invasive ventilation.
Presence of facial anomalies, facial trauma and facial burns.
Presentation of vomiting and severe hematemesis.
Massive hemoptysis.
Hemodynamically unstable patients
Mental confusion.
Patients who do not sign the Informed Consent Form (FICF)"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-9qvwvyw	Analysis of morse taper implants installed at the bone level and 2 mm above bone followed by the installation of crowns printed in hybrid resin	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5179	Analysis of morse taper implants installed at the bone level and 2 mm subcrestally followed by the installation of crowns printed in hybrid resin. clinical, controlled, randomized study with split-mouth model	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-9qvwvyw	<NULL>	Age between 18 and 60 years, need for bilateral unitary rehabilitation with osseointegrated implants in the maxilla or mandible, sufficient bone availability to install a conventional size implant, good systemic health	Smokers and former smokers, diabetics, chronic drug users (eg. Bisphosphonates, Immunosuppressants, anti-inflammatory drugs) or pathologies that alter bone metabolism (eg. Osteoporosis; Diabetes), patients who chronically use anti-inflammatory drugs and antibiotics, people with bruxism, alcoholics, drug addicts, pregnant or wishing to become pregnant in the next year, history of radiotherapy treatment in the head and neck region	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-8g5zfg8	Influence of artificial occlusal interferences on masticatory performance in dentate subjects	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5180	Influence of artificial occlusal interferences on masticatory performance in dentate subjects	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-8g5zfg8	<NULL>	Apparent good general health; complete dentition excluding third molars; diagnosis of Angle’s class I molar and canine relationship; normodivergent facial pattern; absence of cross or open bite; presence of mild dental crowding with lower dental midline deviations of 1 mm; centric slide lower than 2 mm	Presence of systemic, infectious or neoplastic disease; pregnancy or lactation period; dietary regimen; clinical detection of neuromuscular limitations; xerostomia; orofacial pain; dental pain; periodontal disease; dental caries; restorations without adequate anatomy; moderate or severe tooth wear; treatment of orthodontics in the last three years; history or presence of temporomandibular disorders	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-7pns7pj	Role of a viscoelastic solution in cataract surgery	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5181	Medilon safety and performance	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2022-01-24	Oculare Medicina Especializada Ltda	Mediphacos Indústrias Médicas S.A.	https://ensaiosclinicos.gov.br/rg/RBR-7pns7pj	<NULL>	Patients who had a clinical indication for cataract capsular extraction surgery with phacoemulsification with intraocular lens implantation in the posterior chamber. Adult patients 21 years of age or older. Patient with the ability to provide informed consent in the Free and Informed Consent Form approved by the Ethics Committee. Patients willing and able to return for all scheduled follow-up exams for 30 days after surgery.	Mono vision patient. Patient with any anterior segment pathology (examples: keratoconus, dystrophies or significant corneal scarring, guttata, inflammation, edema, dystrophy, etc.) in the eye to be operated. Patient with anterior segment pathology likely to increase the risk of an adverse outcome for phacoemulsification cataract capsular extraction surgery with posterior chamber Intraocular lens implantation (eg pseudoexfoliation syndrome, synechiae, iris atrophy, inadequate dilation, shallow anterior chamber, traumatic cataract, lens subluxation) in the eye to be operated. Patient with any condition that prevents reliable specular microscopy in the eye to be operated on. Patient with uncontrolled glaucoma or glaucoma under treatment. Patient with a history of retinal detachment. Patient with diabetic retinopathy (proliferative or non-proliferative). Clinically significant changes in the pigment epithelium retinal and macula. Severe recurrent anterior or posterior segment inflammation of unknown etiology. Patient with immunodeficiency (infectious, neoplastic or medicated). Patient with chronic use of systemic steroids or immunosuppressive drugs. Patient who participated in any clinical investigation in the eye to be operated within 30 days prior to entry into this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-5d5y7ts	Remote educational intervention in prenatal care for the empowerment of pregnant women in labor and birth	Not yet recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5182	Effect of a remote prenatal educational intervention on empowering pregnant women in labor and birth: a randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-29	Universidade de Pernambuco	Secretaria Municipal de Saúde de Vitória de Santo Antão	https://ensaiosclinicos.gov.br/rg/RBR-5d5y7ts	<NULL>	Pregnant women aged 18 years or over who are undergoing prenatal care at usual risk, exclusively, in family health units and with gestational ages between 25 and 30 weeks, literate and who have a landline and/or cell phone, will be included.	Twin pregnancy; pregnant women over 32 weeks, because at the time of post-intervention collection they may be in labor or may have already given birth, thus compromising the final follow-up of the research, which is data collection during the gestational period; be a health care professional.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-5dvnbqx	Effect of an Adapted Ice Cream on Cancer patients during Chemotherapy	Recruiting	Intervention	2022-01-27	<NULL>	<NULL>	5709	Effect of Adapted Ice Cream ingestion on nutritional, inflammatory and oxidative stress indicators, incidence of oral mucositis and quality of life of individuals with Cancer undergoing Chemotherapy: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-20	Universidade Federal de Santa Catarina	Hospital Universitário Polydoro Ernani de São Thiago	https://ensaiosclinicos.gov.br/rg/RBR-5dvnbqx	<NULL>	individuals aged 19 years or over; both sexes; with recent clinical diagnosis of hematologic cancer or head and neck cancer and with indication to start chemotherapy treatment; in conditions of oral ingestion.	in palliative care; using statins and/or other anti-inflammatory drugs; who have undergone anticancer treatment in the 5 years prior to the survey; diagnosed with infectious contagious diseases; with indication for the use of enteral or parenteral nutrition; who have taken dietary supplements in the 6 months prior to the study; and who have an intolerance or allergy to any component of the adapted ice cream. Pregnant and lactating women will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:16
RBR-4vzrfyf	Effect of cardiopulmonary rehabilitation protocol on functionality, strength of breathing and body muscles and quality of life in COVID-19 patients	Recruiting	Intervention	2022-01-26	<NULL>	<NULL>	5168	Effect of cardiopulmonary rehabilitation protocol on functionality, respiratory muscle e strength, perioheral and quality of life in patients recovered from COVID-19: a controlled and randomizes clinical study	<NULL>	0, randomized-controlled, double-blind	0	<NULL>	<NULL>	<NULL>	2021-10-01	Hospital Otávio de Freitas	Hospital Otávio de Freitas	https://ensaiosclinicos.gov.br/rg/RBR-4vzrfyf	<NULL>	Patients with at least six weeks after the clinical diagnosis of COVID-19, admitted and participating in the post COVID-19 cardiopulmonary rehabilitation protocol;  Over 18 years of age; Both sexes; Presence of symptoms such as dyspnea, fatigue and functional impairment after recovery from COVID-19	Active stage of the disease; Inability to understand and execute commands; Osteoarticular and/or muscle deficit that does not allow walking or with limits to the implementation of the established protocol; Patient diagnosed with lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), Asthma, Cystic Fibrosis, Post Tuberculosis Pulmonary Disease, among others; Patients who have absolute contraindications to perform the six-minute walk test (6MWT) which include the presence of unstable angina, uncontrolled systemic arterial hypertension, recent pulmonary embolism and heart attack that occurred in the month prior to the exam; Patients who drop out of treatment or have no 03 missing	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-57w2gxn	Evaluation of the use of orthostatic postural support equipment during work activities in paraplegic and amputee patients	Recruiting	Intervention	2022-01-26	<NULL>	<NULL>	5169	Physiological and occupational parameters and level of satisfaction of paraplegic and amputees submitted to labor activity with or without the use of postural elevation equipment (STEVE) : A randomized controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-06	Universidade Estadual do Ceará	Dell Computadores do Brasil Ltda	https://ensaiosclinicos.gov.br/rg/RBR-57w2gxn	<NULL>	Adults between 18 and 50 years; both genders; without associated vascular pathologies (clotting disorders, decompensated diabetes, etc.). In the paraplegic group: participants will be included with bilateral lower limb paraplegia; no history of pressure ulcers in the last month in any part of the body; and with stable hemodynamic parameters in the last month (heart rate, blood pressure and oxygen saturation); In the amputee group: patients with lower limb amputations who have been using a prosthesis for at least six months; who are no longer in the process of adapting to prosthesis.	Individuals who present symptoms of dizziness; associated brain neuropathological alterations (cerebrovascular accident, Parkinson&apos;s, Alzheimer&apos;s and traumatic brain injury); severe cognitive/psychological dysfunction that may interfere with the performance of the tests (panic syndrome, major anxiety or depression crises); individuals with relevant speech impairments that make it impossible for them to communicate during the tests and alterations in arterial pressure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-997tqhh	Comparison between Solutions that protect the heart through biopsy and laboratory tests during cardiac surgery.	Recruiting	Intervention	2022-01-26	<NULL>	<NULL>	5170	Comparison between Long term Cardioplegic Solutions in Myocardial protection with Tissue and Laboratory Analysis: Randomized Doubleblind Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Hospital Nossa Senhora da Conceição	Hospital Nossa Senhora da Conceição	https://ensaiosclinicos.gov.br/rg/RBR-997tqhh	<NULL>	All patients who underwent valve replacement surgery or myocardial revascularization with cardiopulmonary bypass at Hospital Nossa Senhora da Conceição, Porto Alegre, aged 18 years or over, in accordance with the Free and Informed Consent Form (Annex B), as Resolution 196/6, of June 13, 1988, of the National Health Council	Previous cardiac surgery; Chronic renal failure (serum creatinine greater than 1.5 mg/dL); Serious psychiatric illness; Urgency or emergency; Multiple surgeries.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-69w6f5z	The effect of music on pain relief in post-cardiac surgery patients	Not yet recruiting	Intervention	2022-01-26	<NULL>	<NULL>	5171	Effect of music on pain relief during the bath in the bed of individuals in post-operative heart surgery: clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Sabrina Daiane Gurgel Sarmento	Hospital Rio Grande	https://ensaiosclinicos.gov.br/rg/RBR-69w6f5z	<NULL>	age eighteen years or older; submit to bed bath in the first twenty-four hours of coronary artery bypass graft surgery; have a score between fourteen and fifteen on the Glasgow Coma Scale	decreased hearing acuity; not following institutional bed bath protocol; changes in vital signs; prescription of analgesics different from the institutional protocol for the postoperative period of cardiac surgery; not liking music or associating it with negative experiences; having undergone surgery anteriorly open heart	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-5x9ry6s	Association of botox with microsurgery of the nasal septum depressor muscle in the treatment of gingival smile.	Data analysis completed	Intervention	2022-01-26	<NULL>	<NULL>	5172	The influence of microsurgery of the nasal septum depressor muscle associated with botulinum toxin in the treatment of gingival smile.	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2020-01-30	Faculdade São Leopoldo Mandic	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-5x9ry6s	<NULL>	Gummy smile above 2mm	Gingival exposure excess (skeletal); use of antibiotics and muscle relaxant: pregnancy and pregnancy; under 18	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-8ht5nqq	Tele Rehabilitation for Women with Urinary Incontinence after Gynecological Pelvic Cancer Treatment.	Not yet recruiting	Intervention	2022-01-26	<NULL>	<NULL>	5173	Tele Rehabilitation Program of the Pelvic Floor in Women with Urinary Incontinence After Surgery, Radiotherapy and/or Brachytherapy for Gynecological Pelvic Cancer: Randomized and Controlled Clinical Trial.	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2022-03-10	Faculdade de Medicina de Ribeirão Preto	Centro de Pesquisa Oncologica	https://ensaiosclinicos.gov.br/rg/RBR-8ht5nqq	<NULL>	Age group older than 18 years; Clinical staging I to III of pelvic gynecological cancer; Having undergone surgery, radiotherapy, and/or brachytherapy; Have urinary incontinence; Do not present any orthopedic or neurological limitations that prevent the practice of the rehabilitation program; Not being under physiotherapeutic treatment.	Withdrawal of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-10wnp828	The effect of a cognitive stimulation program on attention, memory, reasoning, language, mood and social network of elderly people without dementia and without depression: an experience with three groups randomly selected.	Recruiting	Intervention	2022-01-25	<NULL>	<NULL>	5164	The effectiveness of a cognitive stimulation program with multifactorial components on cognition and psychosocial variables in elderly people without dementia and without depression: a randomized controlled trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Instituto Supera de Educação Ltda	Escola de Artes, Ciências e Humanidades da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-10wnp828	<NULL>	Study participants must be 60 years old or older, and will be invited based on a series of cohabitation centers for the elderly and associations of retirees. To participate in the study, it is necessary that the participant has not performed and participated in any cognitive intervention, such as memory training workshops, among others. The objective is to invite 180 participants, where they will be randomly randomized, to the training group (GT), active control group (GCA) and passive control group (GCP). 60 participants will be directed to each group, through randomization and combinatorial analysis in a statistical program, also aiming at a possibility to keep the groups as homogeneous as possible in relation to age and education. The elderly who participate in the groups GCA and GCP, will be invited to participate in the same cognitive training program, offered to the GT.	Study participants must be 60 years old or older, and will be invited based on a series of cohabitation centers for the elderly and associations of retirees. To participate in the study, it is necessary that the participant has not performed and participated in any cognitive intervention, such as memory training workshops, among others. The objective is to invite 180 participants, where they will be randomly randomized, to the training group (GT), active control group (GCA) and passive control group (GCP). 60 participants will be directed to each group, through randomization and combinatorial analysis in a statistical program, also aiming at a possibility to keep the groups as homogeneous as possible in relation to age and education. The elderly who participate in the groups GCA and GCP, will be invited to participate in the same cognitive training program, offered to the GT.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-7wfrs6k	Determination of Anatomic Diameters in Different Dental Groups - An &quot;In Vivo&quot; Study	Data analysis completed	Intervention	2022-01-25	<NULL>	<NULL>	5165	Determination of Anatomic Diameters in Different Dental Groups - An &quot;In Vivo&quot; Study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-12	Universidade Paranaense	Universidade Paranaense	https://ensaiosclinicos.gov.br/rg/RBR-7wfrs6k	<NULL>	Patients with one or more dental elements indicated for radical endodontic treatment; that have complete root formation	Dental elements with previously performed endodontic treatments; root curvatures; root resorption processes; anatomical complexity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-66n5c5r	Effects of Cognitive Behavioral Couple Therapy combined with Mindfulness on mindful attention, depressive symptoms and dyadic adjustment: A randomized clinical trial	Data analysis completed	Intervention	2022-01-25	<NULL>	<NULL>	5166	Cognitive Behavioral Couple Therapy Combined with Mindfulness	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-04-15	Universidade Metodista de São Paulo	Universidade Metodista de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-66n5c5r	<NULL>	age between 18 and 60 years; being in a heterosexual relationship; Portuguese as their mother tongue; literate and having education level up to complete higher education; having one or more year of marriage or cohabitation; to present conflict in the relationship related to communication difficulties (we used the Romantic Partner Conflict Scale adapted); naive practitioner in the Mindfulness meditation exercise; monthly income per family up to R$6,000,00; having consent of both spouses to participate in the study.	Having any severe clinical psychological disorder; being drug addict or taking psychiatric medication (we used the interview, the Alcohol, Smoking, and Substance Involvement Screening Test - ASSIST, and the General Health Questionnaire - GHQ-12).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-7gw2794	Auditory and visual stimuli test proposal for tinnitus patients evaluation	Not yet recruiting	Observational	2022-01-25	<NULL>	<NULL>	5167	An auditory-visual Stroop test proposal for tinnitus patients evaluation	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-02-20	Universidade Federal de São Paulo (UNIFESP-EPM)	Universidade Federal de São Paulo (UNIFESP-EPM)	https://ensaiosclinicos.gov.br/rg/RBR-7gw2794	<NULL>	As inclusion criteria, will be selected, individuals aged between 18 and 59 years old, with tinnitus and hearing thresholds within normal limits for pure tone audiometry or hearing loss at high frequencies (above 3kHz). Such subjects must have performed acuphenometry in a previous audiological evaluation and must present constant subjective tinnitus, of the whistle or wheezing type, uni or bilateral. The Control Group will comprise individuals without tinnitus, aged between 18 and 59 years, pure tone audiometry within normal limits or with hearing loss at high frequencies (from 3kHz), with no history of neurological and/or psychiatric alterations.	Individuals with pulsatile tinnitus, psychiatric or neurological diseases diagnosed up to the time of test execution will be excluded from the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-3chg6v5	Use of Transcranial Direct Current Stimulation Combined with Proprioceptive Exercises in Visually Impaired Children and Preadolescents	Recruiting	Intervention	2022-01-24	<NULL>	<NULL>	5163	Effect of Transcranial Stimulation by Direct Current Associated With Exercises Proprioceptives in Children and Pre-adolescents with Aquired and Congenital Visual Impairment	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-30	Universidade Evangélica de Goiás- UniEVANGÉLICA	Universidade Evangélica de Goiás- UniEVANGÉLICA	https://ensaiosclinicos.gov.br/rg/RBR-3chg6v5	<NULL>	Inclusion criteria consist of the adherence of children and pre-adolescents aged 6 to 12 years; who have a previous clinical diagnosis of blindness or low vision; have preserved cognitive ability to understand and collaborate with the procedures involved in the study; authorization of parents or guardians for the participation of minors in the research	Individuals who have undergone surgical procedures in the last 12 months before the start of the training sessions will be excluded; have structured orthopedic deformities in the upper limbs or spine with surgical indications; patients with uncontrolled epilepsy; have a metallic implant in the brain or hearing aids; associated neurological pathology; and cardiac pacemaker	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-3f8dm6q	Olfactory training with essential oils in patients with olfaction sequelae after COVID-19	Data analysis completed	Intervention	2022-01-23	<NULL>	<NULL>	5160	Advanced olfactory training in post-COVID patients	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Complexo Hospital de Clínicas da Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-3f8dm6q	<NULL>	Patients who complain of anosmia or hyposmia after SARS-CoV-2 infection less than 3 months after symptom onset; convalescing from her COVID-19 disease, with onset of disease symptoms for at least 4 weeks; Patients who underwent RT-PCR test at symptom onset, with detection of SARS-CoV-2; Patients who can give valid written informed consent; Patients motivated to participate in the study; Adult patients aged 18-60 years.	Patients who cannot give valid written informed consent; Patients with a previous history of more than one SARS-CoV-2 infection Patients with nasosinusal diseases such as chronic rhinosinusitis or nasal masses; History of previous traumatic brain injury with olfactory sequelae; History of olfaction disorder prior to SARS CoV-2 infection; Patients with any diagnosed neurological disease known to affect olfactory function; Patients unable to read Portuguese; Patients who are already using an oral glucocorticoid; Patients who have already started some form of therapy for the olfactory disorder caused by COVID-19; Known hypersensitivity to any item used in any of the proposed olfactory training;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-7dnjqhd	Efficacy of topical or oral hydrolyzed collagen for dermatoporosis in women	Terminated	Intervention	2022-01-21	<NULL>	<NULL>	5156	Prospective, double-blind, randomized, placebo-controlled clinical study of effects of oral and topical use of collagen hydrolyzate in dermatoporosis	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2016-06-07	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7dnjqhd	<NULL>	Women aged over 60 years, healthy, menopause; Phototypes II and III - Fitzpatrick classification 1988; Clinical diagnosis of stage I and IIa dermatoporosis in the forearms	Topical treatment of the forearms with retinoids, alpha-hydroxy acids, polyhydroxy acids, beta-hydroxy acids and ascorbic acid for less than 3 months; Topical treatment of the forearms with formulations containing collagen peptides for less than 3 months; Previous treatment with oral retinoids less than 6 months before; Pre-treatment with nutraceuticals and oral supplements less than 3 months before (except calcium and vitamin D); Treatment with superficial chemical peels, microdermabrasion and/or laser non-ablative in forearms for less than 3 months; Current smoking; Chronic use of corticosteroids (systemic or topical on the forearms) and/or chronic use of non-hormonal anti-inflammatory drugs; Chronic Kidney Failure; Insulin-dependent diabetes mellitus; Use of anticoagulants (including acetylsalicylic acid); Transplant patients; Presence of photodermatosis; Presence of inflammatory or infectious skin disease in the superior limbs; Chemotherapy for less than 3 months; Clinical evidence of immunosuppression; Hormone replacement therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-2nhgvn6	Reiki&apos;s effectiveness for anxiety in the preoperative period of heart surgery	Recruitment completed	Intervention	2022-01-21	<NULL>	<NULL>	5157	Reiki&apos;s effectiveness for anxiety in the preoperative period of heart surgery: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-02-01	Escola de Enfermagem da Universidade de São Paulo	Escola de Enfermagem da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-2nhgvn6	<NULL>	Patients over 18 years old; with preoperative risk assessment classified as low or medium by Euroscore (0 to 5 points)	Patients who are in the following conditions: scheduling urgent or emergency surgerie; combined surgeries; minimally invasive surgeries; using antipsychotics and anxiolytics; unable to walk (to go from the bed to the place where the session will be held); with neurological changes and with mental and cognitive changes that prevent them from answering questions; patients with changes in the mouth or a history of head and neck diseases that may alter the results of aslivar amylase will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-9jmw7k3	Effects of β-alanine supplementation on performance and recovery in Crossfit practitioners	Not yet recruiting	Intervention	2022-01-21	<NULL>	<NULL>	5158	Effects of chronic β-alanine supplementation on physical performance and recovery in Crossfit practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-24	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9jmw7k3	<NULL>	Healthy volunteers; both genders; non smokers; age between 18 and 40 years; Crossfit® practitioners who train in the most advanced category of the modality, in which they perform the movements and training loads as prescribed by the trainer (category RX) for at least 3 months.	Vegetarian or vegan volunteers; with use of anti-inflammatory drugs; with the use of anabolic steroids.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-10gx2qhj	Efficacy of the oral use of the drug melatonin in the treatment of facial melasma in women.	Not yet recruiting	Intervention	2022-01-21	<NULL>	<NULL>	5159	Efficacy of the use of oral melatonin in the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled clinical trial.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Faculdade de Medicina de Botucatu (FMB Unesp)	Faculdade de Medicina de Botucatu (FMB Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-10gx2qhj	<NULL>	Women with facial melasma 18 to 60 years old, Fitzpatrick&apos;s phototypes II to V.	Patients with other concomitant facial skin diseases, skin diseases with photosensitivity, melasma with mMASI less than 5, history of hypersensitivity to the active substance oral melatonin or to any other component of the formulation described, pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-7yryyk7	Effect of exergaming on the quality of life and learning of autism spectrum disorder individuals	Recruiting	Intervention	2022-01-20	<NULL>	<NULL>	5155	Effect of exergaming on the quality of life and learning of autism spectrum disorder individuals	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-01	Universidade do Vale do Sapucaí	Universidade do Vale do Sapucaí	https://ensaiosclinicos.gov.br/rg/RBR-7yryyk7	<NULL>	"Experimental Group 1: volunteers of both genders; aged between 8 and 14 years; who have a diagnosis of autism spectrum disorder; with medical clearance for the practice of the intervention.
Experimental Group 2: volunteers of both genders; aged between 8 and 14 years; do not have a diagnosis of autism spectrum disorder and/or any disease; with medical clearance for the practice of the intervention."	Volunteers under the age of 8 and over 15 will be excluded; cognitive difficulty regarding the assessment and intervention instruments; infectious diseases; incapacitating diseases of the upper and lower limbs; patients with myopathies; diseases with recognized collagen alteration; people with neurological diseases; for personal reasons do not want to participate.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-3786p33	Video otoscope utility in membrane tympanic perforation	Recruiting	Intervention	2022-01-19	<NULL>	<NULL>	5154	Diagnostic accuracy of video otoscope in membrane tympanic perforation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-07	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3786p33	<NULL>	Volunteers seen at the otolaryngology clinic at the study site; both sexes; age over 8 years old; presence of symptoms such as otalgia, otorrhea, hearing loss and tinnitus.	Volunteers with a previous history of tympanic membrane perforation in the medical record; presence of obstruction in the external ear canal.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-4byhxb6	Dynamic Registry TARGET Brazil  - single arm, prospective, multicenter and observational trial	Recruiting	Observational	2022-01-18	<NULL>	<NULL>	5150	Dynamic Registry TARGET Brazil	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-27	Microport Scientific Vascular Brasil LTDA	Microport Scientific Vascular Brasil LTDA	https://ensaiosclinicos.gov.br/rg/RBR-4byhxb6	<NULL>	Volunteers over 18 years of age; percutaneous coronary intervention in less than 96 hours, performed according local interventional cardiology laboratory routine, with implantation or attempted implantation of one or more Firehawk stents for the treatment of symptomatic ischemic heart disease and/or with objective evidence of myocardial ischemia; patient will be informed of the nature of the study, agree to the follow up and provide written informed consent, approved by the local Ethics Committee.	Planned cardiac or non-cardiac surgery within 6 months of the index procedure; Patient with a life expectancy of less than 12 months; Any significant medical condition that in the investigator&apos;s opinion may interfere with optimal patient participation in this study; Participation in another survey in the last 12 months, unless that there may be direct benefit to the research subject; Percutaneous coronary intervention performed for the treatment of non-atherosclerotic coronary heart disease; Percutaneous coronary intervention performed for the treatment of previously implanted stent thrombosis; There are no restrictions regarding the number of lesions or stents treated, the treated arteries or the morphology of the lesions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-10qps233	Monitoring risk of COVID-19 infection in elderly care at home	Recruitment completed	Intervention	2022-01-18	<NULL>	<NULL>	5151	Monitoring risk of COVID-19 infection in elderly people in home care	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2020-09-29	Patricia Freire de Vasconcelos	Universidade da Integração Internacional da Lusofonia Afro-Brasileira	https://ensaiosclinicos.gov.br/rg/RBR-10qps233	<NULL>	Accompanying elderly people over 18 years of age and who is the main caregiver; Have a telephone for personal or home use that allows the researchers to contact them; Know how to read or be able to answer phone calls OR have a caregiver who can read or is able to answer phone calls.	Elderly considered a suspected case of the new coronavirus (COVID-19); Elderly in hospital during the period of research data collection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-9n4z2hh	Non-invasive electrical brain stimulation in patients with vasculitis	Recruiting	Intervention	2022-01-18	<NULL>	<NULL>	5152	Non-invasive brain neuromodulation in patients with primary systemic vasculitis: a randomized, double-blind, sham-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9n4z2hh	<NULL>	Diagnosis of Takayasu&apos;s Arteritis or Granulomatosis with Polyangiitis; diagnosis of chronic fatigue; older than 18 years; both sexes; read and understand the informed consent form.	Presence of neoplasm; critical/symptomatic aortic stenosis; Congestive heart failure; arrhythmias; ST-segment electrocardiographic changes; coronary heart disease; cardiac pacemaker users; users of cranial metal clips or prostheses; the presence of fibromyalgia; with severe walking impairment; pregnant or lactating patients; seizures or epilepsy; user of drugs acting on the central nervous system; skin lesion on the scalp.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-4dcjfr7	Therapy with Nerve Electrical Stimulation associated with the drug Desmopressin for the treatment of children who wet the bed during their sleep	Not yet recruiting	Intervention	2022-01-18	<NULL>	<NULL>	5153	Desmopressin-associated Transcutaneous Parasacral Nerve Stimulation in Monosymptomatic Enuresis: a blinded, randomized, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal de Minas Gerais	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4dcjfr7	<NULL>	Children and adolescents aged 6 to 11 years, 11 months and 29 days with a diagnosis of primary NME; not receiving any enuresis treatment modality in the last 2 months; children and adolescents whose parents or guardians agreed to participate in the study, after reading, understanding and signing the Informed Consent Form (FICF) and Informed Consent Form.	"Use of medication that changes the action of the detrusor muscle or external urethral sphincter; use of pacemaker; presence of polydipsia of any etiology;presence of moderate to severe intellectual disability of any nature identified by Raven&apos;s Progressive Matrices Test; families who refuse to attend the research clinic once a week
- Children and adolescents diagnosed with primary NME and whose parents or guardians did not accept to participate in the study and/or did not sign an Informed Consent Form (FICF) and an Assent Term
- Non-monosymptomatic or secondary enuresis"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-29jhy2r	Pilates method in the treatment of people with Arthrosis of the knee	Recruitment completed	Intervention	2022-01-17	<NULL>	<NULL>	5149	"The influence of the Pilates method on improving pain and function in
elderly with Osteoarthritis of the knee"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2017-03-07	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-29jhy2r	<NULL>	Age from 60 years old; light or moderate knee osteoarthritis; both sexes;	stroke; parkinson disease; alzheimer; use of pacemaker; unstable cardiac conditions; knee or hip arthroplasty; fibromyalgia; amputees; visual deficiency; hearing impairment without amplification orthosis; in physiotherapeutic treatment or academy training in the last 3 months; incomplete primary school education; uncontrolled blood pressure; several knee osteoarthritis; have three consecutive absences;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-6wpdvjk	Effects of radiofrequency and microneedling on the quality of life in women with white marks	Data analysis completed	Intervention	2022-01-13	<NULL>	<NULL>	5145	Effects of radiofrequency and microneedling on the quality of life in women with alba stretches	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-6wpdvjk	<NULL>	Volunteers in good health; who did not have severe circulatory or healing problems; who had not undergone any treatment for the dysfunction in the past 6 months	Volunteers who were being treated with photosensitive drugs, anti-inflammatory drugs, antibiotics, immunosuppressive drugs; with suspicion or pregnancy plans; who have used retinoids in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-4vcfjmm	Influence of light intensity on body responses after physical exercise performed in the evening	Recruiting	Intervention	2022-01-13	<NULL>	<NULL>	5146	Influence of light intensity on hemodynamic, autonomic and circadian rhythm after aerobic exercise performed in the evening	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4vcfjmm	<NULL>	Men; age between 20 and 40 years old; blood pressure levels below 140/90 mmHg; absence of cardiovascular diseases; no smoking; no highly physically active; no use of regular medications, nutritional or ergogenic supplements; no extreme morningness and eveningness chronotype	Body mass index higher than 30kg/m²	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-4wtq84v	Auriculotherapy in the treatment of gestational nausea and vomiting: a randomized clinical trial	Not yet recruiting	Intervention	2022-01-13	<NULL>	<NULL>	5312	Technological innovations and integrative and complementary therapies in obstetric care	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Universidade Estadual de Londrina	Universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-4wtq84v	<NULL>	"Pregnant women referred to the AEHU (Ambulatório de Especialidades do Hospital Universitário) from prenatal care at usual risk will be included, and pregnant women at usual risk attended at the basic health units of the network of the city of Londrina, Paraná, with chronological age over 18 years old; gestational age between 5 and 16 weeks confirmed by ultrasound, regardless of parity, who report symptoms of nausea and/or vomiting of a mild degree (PUQE score less than 6) or moderate (PUQE score between 7 and 11)
*PUQE: (Pregnancy Unique Quantification of Emesis)"	Pregnant women with diagnosed mental retardation and suicidal idealization will be excluded; coagulation disorders; in pharmacological treatment for psychosomatic illness such as anxiety and depression; hyperthyroidism; dermatological lesion in the pinna; unexplained fever; multiple pregnancy; gestational trophoblastic disease, hyperemesis gravidarum; use of antiemetic; diarrhea; pregnant women with fetuses with Down syndrome, and pregnant women afraid to receive the semi-permanent needle	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:01
RBR-7jx2byj	Treatment of Endometriosis using the drug methotrexate associated with lipid substances that facilitate the action of medication at the site of the disease	Data analysis completed	Intervention	2022-01-11	<NULL>	<NULL>	5141	Treatment of Deeply infiltrative endometriosis with intravenous methotrexate carried in lipid core nanoparticles (LDE-ddMtx): a prospective pilot study	<NULL>	1-2, single-arm-study, open	1-2	<NULL>	<NULL>	<NULL>	2019-06-20	Faculdade de Medicina da Universidade de São Paulo - USP	Centro de Estudo e Pesquisa do Hospital Perola Byington	https://ensaiosclinicos.gov.br/rg/RBR-7jx2byj	<NULL>	We included women in the reproductive period between 30 and 50 years, with no future intention of pregnancy; DIE affecting at least the inner muscular intestinal layer; with at least one pelvic pain symptom (dysmenorrhea, deep dyspareunia, chronic pelvic pain, dyschezia and/or dysuria during the menstrual period) with a score of 7 or higher on the visual analogue scale (VAS) (Maxwell et al., 1978), with no current use of hormone therapy including gonadotropin-releasing hormone (GnRH) analogs or progestogens for at least six months prior to the beginning of the study or no use of combined hormonal contraceptives for three months prior to medication of the present study or still use of any hormonal therapy and maintain complaints of significative pain (VAS equal or higher than 7); and no pregnancy.	Breastfeeding, any immunodeficiency, alcoholism, peptic ulcer, hepatic, renal or hematological disorders, active lung disease and known sensitivity to methotrexate	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-2ggx7sm	Vaccine Plasma for the Treatment of COVID-19 Infection	Not yet recruiting	Intervention	2022-01-11	<NULL>	<NULL>	5142	"COVID-19-vaccinated plasma for treatment of the infection by SARS-CoV-2: a Multicenter,
Randomized, Open-Label, Parallel-Group Trial"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-13	Ministério da Ciência, Tecnologia e Inovações	Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS	https://ensaiosclinicos.gov.br/rg/RBR-2ggx7sm	<NULL>	Age ≥ 18 years with or without comorbidity; COVID-19 mild (WHO clinical progression scale ≤ 2); Symptoms duration less than 72 hours; Laboratory confirmation of COVID-19, by detecting the viral antigen in respiratory secretions, collected by nasal swab (PanbioTM COVID-19 Ag, Abbott®); Signature, by the patient or a legal representative, of the informed consent form	Pregnant women; Patients in palliative care; Refusal to sign the TCLEP; Patients immunized with two doses of the immunizers, with the exception of individuals over 80 years of age who have been immunized with Coronavac vaccine for more than 6 months; Patients with suspected reinfection; Allergic reactions prior to plasma transfusion	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-5cyj66b	Analysis of laser acupuncture in children and adolescents undergoing chemotherapy.	Recruitment completed	Intervention	2022-01-11	<NULL>	<NULL>	5143	Analysis of laser puncture in the improvement of symptoms of pain, fatigue and nausea in children and adolescents with cancer.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-06-01	Universidade Federal de Santa Catarina	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-5cyj66b	<NULL>	Be between 8 and 15 years of age; clinical diagnosis of cancer, being undergoing chemotherapy within the time of the research (the participant may be receiving chemotherapy or during the same period), being hospitalized in the oncology unit of HIJG (Joana de Gusmão Children&apos;s Hospital), having received the diagnosis of cancer for at least 10 days.	Parents or responsible medical staff do not accept participation in the research; children or adolescents admitted to the ICU with end-stage cancer or an inconclusive clinical diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-2h39fm9	Nerve plexus block associated with spinal anesthesia without morphine for hip surgery: A comparative to spinal anesthesia with morphine	Recruitment completed	Intervention	2022-01-11	<NULL>	<NULL>	5144	The shamrock lumbar plexus block associated with spinal anesthesia for hip surgery: a comparison with intrathecal morphine	<NULL>	3, randomized-controlled, single-blind	3	<NULL>	<NULL>	<NULL>	2018-11-01	Hospital e Maternidade Marieta Konder Bornhausen	Hospital e Maternidade Marieta Konder Bornhausen	https://ensaiosclinicos.gov.br/rg/RBR-2h39fm9	<NULL>	This study included patients who underwent elective or emergency surgery for hip fracture correction or hip prosthesis insertion, who voluntarily agreed to participate in this research, over 18 years old, with a score of 15 on the Glasgow Coma Scale, with ability to correctly answer the questionnaire applied by the researcher and who signed the informed consent form.	The patients excluded from this work were those who underwent emergency surgery; who reported allergy to local anesthetics (both ropivacaine and bupivacaine); who presented local skin infection where both spinal anesthesia and lumbar plexus block should be punctured were excluded from this study; severe coagulation disorder or use of anticoagulants not paused for adequate time; who had pathologies that prevented the positioning for performing lumbar plexus block or spinal anesthesia; who had neurological symptoms present at the site of innervation related to the lumbar plexus; who had hemodynamic instability; , defined in the study as systolic blood pressure less than 90 mmHg, heart rate greater than 110 beats per minute or need for vasoactive drugs; those who had intracranial hypertension or who were in the presence of sepsis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-8t9bqkg	Children with Developmental Coordination Disorder: relationships and predictors of motor deficits and the current and longitudinal interventional impact	Data analysis completed	Intervention	2022-01-10	<NULL>	<NULL>	5140	Children with Developmental Coordinating Disorder: relationships and predictors of motor deficits and the current and longitudinal interventional impact	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-01-15	Universidade Federal do Rio Grande do Sul	Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-8t9bqkg	<NULL>	Children from low-income families (criterion defined from the economic classification questionnaire of the Brazilian Association of Research Companies); age between 6 and 7 years; overweight or obese (defined by Body Mass Index); proper weight (defined by Body Mass Index); with motor delay.	Children under 6 and over 7 years old; children from middle and upper socioeconomic classes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-69hn7t8	Clinical and patient-centered outcomes from the palatal donor area submitted to two forms of protection after free gingival graft removal	Recruiting	Intervention	2022-01-07	<NULL>	<NULL>	5137	Clinical and patient-centered outcomes from the palatal donor area submitted to two forms of protection after free gingival graft removal: a randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-11	Faculdade de Odontologia da Universidade Federal de Pelotas	Faculdade de Odontologia da Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-69hn7t8	<NULL>	Age 18 years and over; not having reported systemic diseases; have a healthy periodontal or demonstrate stable periodontal condition after conventional periodontal therapy; have gingival bleeding index and bacterial plaque index less than 15%; have clinical indication for periodontal plastic surgery using connective tissue graft, in order to treat single gingival recession defects, around natural teeth located in the anterior region of the mandible (canine to canine); no history of previous palatal harvest	Pregnancy or infants; report the use of medications that would adversely affect periodontal tissues; have inadequate endodontic treatment; smokers or former smokers who have stopped smoking less than a year ago; possess tooth mobility at the surgery site; possessing the need for orthodontic treatment prior to the completion of root coverage surgery	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-92z99d2	Strategy for increase vaccine coverage for influenza in diabetic patients at a tertiary university hospital - a randomized clinical trial	Recruitment completed	Intervention	2022-01-07	<NULL>	<NULL>	5138	Evaluation of vaccine coverage for influenza in patients with diabetes at a tertiary center	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-01	Universidade Federal de Santa Maria (UFSM)	Universidade Federal de Santa Maria (UFSM)	https://ensaiosclinicos.gov.br/rg/RBR-92z99d2	<NULL>	Individuals of both sexes and of any age; diagnosed with diabetes mellitus of any etiology; who were treated at the endocrinology, metabolism, pediatric endocrinology and internal medicine clinics of the University Hospital of Santa Maria; patients who had this diagnosis recorded in their medical records or who were using insulin or oral antidiabetics were considered diabetic	Diagnosis of gestational diabetes mellitus; Presence of any contraindication to flu vaccination reported by the patient or recorded in the medical record, such as allergy to formula components	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-75m3n33	Go Wish Cards: Clinical Trial	Recruiting	Intervention	2022-01-07	<NULL>	<NULL>	5139	Effect of Go Wish Cards on the identification of end-of-life wishes of patients with advanced cancer in palliative care: Clinical Trial	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Hospital de Câncer de Barretos	Hospital de Câncer de Barretos	https://ensaiosclinicos.gov.br/rg/RBR-75m3n33	<NULL>	Patients over 18 years of age, Both sexes, Aware of the diagnosis of cancer in an incurable condition;,Karnofsky performance scale equal to or greater than 40%, Who wish to talk about their end-of-life wishes, Who are cognitively able to understand the Go wish cards proposal and its subsequent approaches (a brief assessment will be made by the researcher with questions such as time, space, full name, age)	Patients with dementia syndromes or patients with a psychiatric diagnosis that prevent adequate reflection and conduct of research demands, such as Depression, Schizophrenia, Bipolar Affective Disorder and Panic Syndrome; Delirium patients; Patients with limitations to effective communication with the researcher, such as aphasia, dysarthria and dysfunctional phonation due to the disease or therapy; Patients with impaired hearing that prevent them from adequately understanding the questions asked by the researcher	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-8dzrvjg	Biperiden effect to reduce the desire to use cocaine/crack	Data analysis completed	Intervention	2022-01-06	<NULL>	<NULL>	5135	Effects of biperiden (muscarinic antagonist) on cocaine/crack dependence	<NULL>	3, randomized-controlled, double-blind	3	<NULL>	<NULL>	<NULL>	2018-06-09	Universidade Federal de São Paulo	Secretaria Nacional de Cuidados e Prevenção às Drogas - SENAPRED	https://ensaiosclinicos.gov.br/rg/RBR-8dzrvjg	<NULL>	male; age between 18 and 70 years; severe disorder related to the use of cocaine or crack according to the Diagnostic and Statistical Manual of Mental Disorders criteria, 5th edition (DSM-5 criteria) (published by  American Psychiatric Association, 2013)	other severe psychiatric disorders severe, such as schizophrenia and bipolar mood disorder; severe dependence criteria for other drugs (except tobacco); severe cognitive impairment; Illiteracy; compulsory hospitalization; hearing deficiency; transference to other health service with no partnership with the project; hospitalization discharge due to agressive issues or at the request of the participant; previous use of biperiden	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-3nsdfy6	Analysis carried out to verify whether the bandage that fixes the dressings, causes skin allergy	Recruiting	Intervention	2022-01-06	<NULL>	<NULL>	5136	Evaluation of primary irritability potential, accumulated and skin sensitization of a bandage (090997-01) in controlled and maximized conditions (RIPT)	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Kors do Brasil Produtos Paramédicos	Kors do Brasil Produtos Paramédicos	https://ensaiosclinicos.gov.br/rg/RBR-3nsdfy6	<NULL>	Agreement to comply with safety guidelines in order to minimize the risks of contamination by COVID 19; healthy subjects; intact skin in the test region; agreement to adhere to the trial procedures and requirements and to attend the institute on the day(s) and time(s) determined for the evaluations; ability to give written consent to their participation in the study; 18 to 59 years old; phototype (Fitzpatrick): I to IV; any gender	Subjects who are to the risk group for COVID 19, i.e., with diabetes; chronic cardiovascular; renal and respiratory disorders; immunosuppressed or other conditions deemed by the physician as belonging to the risk group; pregnant or lactating women; skin marks in the experimental area that interfere with the assessment of possible skin reactions (pigmentation disorders; vascular malformations; scars; increased hairiness; ephelides and nevus in large quantities; sunburn); active (local or disseminated) dermatoses that may interfere with the study results; history of allergic reactions; irritation or intense feelings of discomfort to topical products: cosmetics; health products or medicines; history of atopy (atopic dermatitis; allergic rhinitis; allergic bronchitis; allergic conjunctivitis; etc.); feeling of discomfort with temperature changes (too hot, too cold) and or when using the air conditioning; Subjects with a history of allergy to the materials used in the study; subjects with a known allergy to acrylates; history of pathologies aggravated or triggered by ultraviolet radiation; immunodeficient patients; intense sun exposure or tanning session within 15 days before the initial assessment; predicted intense sun exposure or tanning session during the study period; 11 de 23 MOD_PRO_CEP Rev. 05 All-S-RIPT-SO-PAD-090997-01-06-21-PROF-V01; prediction of bathing in the sea, swimming pool or bathtub during the study; subjects who practice water sports; dermographism; body aesthetic and or dermatological treatment within 03 weeks before enrolment; use of the following medications for topical or systemic use: immunosuppressants; antihistamines; non-hormonal anti-inflammatory drugs and corticosteroids up to 2 weeks before selection or; considering storage corticosteroids; the interval should be 1 month before enrolment; Treatment with acidic vitamin A and or its derivatives; orally or topically; within 01 month before the beginning of the study; predicted vaccination during the study or within 03 weeks before the study; participating or have participated in another clinical study completed less than 07 days before the enrolment, in case the previous study is acceptable in use; participating in or have participated in another clinical study completed less than 21 days ago; if the previous study is a compatibility study or an adverse reaction investigative study; any condition not mentioned above that; in at the investigator&apos;s opinion; may compromise the study evaluation; history of non-adherence or unwillingness to adhere to the study protocol; professionals directly involved in carrying out this protocol and their families	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-5jnbyhk	Effect of hospitalization on nutritional status and risk of dysphagia in people older than 65 years of age	Not yet recruiting	Observational	2022-01-03	<NULL>	<NULL>	5133	Impact of hospitalization on nutritional status and the risk of dysphagia in people aged 65 years. Multicentre study &quot;NUTRIFAG&quot;	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-08-01	Department of Nursing, University of Alicante, Alicante Institute for Health and Biomedical Research (ISABIAL),	Universidad de Alicante	https://ensaiosclinicos.gov.br/rg/RBR-5jnbyhk	<NULL>	patients 65 years of age or older; hospitalized in medical or surgical units; admitted for more than 48 hours; informed consent of the patient or legal guardian	patients with enteral or parenteral nutrition on admission; terminally ill patients or patients with a primary diagnosis of cancer; patients admitted to critical care units	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-8fp63gm	Different follow-up models for the treatment of obesity in adolescents	Recruiting	Intervention	2022-01-03	<NULL>	<NULL>	5134	Effects of different intervention models for the treatment of obesity in adolescents	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Laboratório Interdisciplinar de Intervenção em Promoção da Saúde (LIIPS)	Instituto Cesumar de Ciência, Tecnologia e Inovação	https://ensaiosclinicos.gov.br/rg/RBR-8fp63gm	<NULL>	As inclusion criteria, adolescents with the following characteristics will be accepted: a) present between 12 and 17 years of age; b) being overweight or obese within the cutoff ranges and c) being available to participate in theoretical-practical interventions 3x a week (on Mondays, Wednesdays and Fridays) for 14 weeks, that is, 1 week of assessments, 12 weeks of interventions and 1 week of reassessments.	Exclusion criteria will be: a) use of glucocorticoids and/or psychotropic medications that can be used regularly; b) frequency of less than 75% in the different theoretical-practical activities that will be practiced; c) osteomyoarticular limitations that prevent the regular and systematic practice of physical exercises. at the time any teenager decides to participate in another nutritional guidance program or other physical exercise proposals, as well as decide to start a diet, low in calories, low in carbohydrates or low in fat, they will not be included in the statistical analyses.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-2jkwm3x	Effect of respiratory physiotherapy maneuvers in preterm infants: Randomized Clinical Trial	Recruiting	Intervention	2021-12-30	<NULL>	<NULL>	5131	Effect of the application of the thoracoabdominal rebalancing method (RTA) in moderate premature infants: Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Alfenas - UNIFAL	Hospital de Clínicas de Itajubá - HCI	https://ensaiosclinicos.gov.br/rg/RBR-2jkwm3x	<NULL>	Moderate premature newborn patients (32 to 36.6 gestational weeks; both sexes; weight up to 2.500g; admitted to the Neonatal Intensive Care Unit of the Hospital de Clínicas de Itajubá,  Minas Gerais); need for mechanical ventilation or not; with prescription respiratory physiotherapy physician, are not under analgesia and sedation.	Contraindication to respiratory physiotherapy, risk of intracranial hemorrhage; hemodynamic instability; blood dyscrasias; newborns with congenital malformations; genetic syndromes; those whose parents do not agree with the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-542d26f	Assessment of the physical and functional capacity of burnt subjects at hospital discharge and follow-up outpatient return	Recruiting	Observational	2021-12-29	<NULL>	<NULL>	5130	Assessment of the physical and functional capacity of burnt subjects at hospital discharge and follow-up outpatient return	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-08-09	Universidade Estadual de Londrina-UEL	Programa de Pós-Graduação em Ciências da Reabilitação- UEL	https://ensaiosclinicos.gov.br/rg/RBR-542d26f	<NULL>	Age 18 years or over; both genders; admitted to the Burn Treatment Center of the University Hospital of Londrina, with a diagnosis of burn of any length and depth of the body surface; absence of the following conditions: visual deficit; osteo-neuromuscular dysfunction that compromises gait, balance or shoulder range of motion, unrelated to the burn; severe cardiovascular and/or respiratory disease prior to the burn; acceptance to participate in the research, signing an informed consent form.	Patients unable to complete the study protocol for any reason, such as inability to answer questions asked during testing or excessive pain during testing; those who wish to withdraw from the study at any time.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-10z7j4jd	A portable irradiation device for the improvement of photodinamic therapy	Recruitment completed	Observational	2021-12-29	<NULL>	<NULL>	7846	A portable device for photodynamic Therapy to improve treatment reducing the time under treatment at the hospital	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-01-01	Instituto de Física de São Carlos	Hospital Amaral Carvalho	https://ensaiosclinicos.gov.br/rg/RBR-10z7j4jd	<NULL>	both sexes; older than 18  years; basal cell carcinoma lesions with less than 2 cm diameter; patients presenting multiple lesions can be included if the lesions have less than 2 cm diameter.	allergies from any compound of the formula; infiltrative or sclerodermiform basal cell carcinoma, as well as other skin cancers like squamous cell carcinoma or melanoma;  patients with pophyria diagnosis; basal cell carcinoma lesions larger than 2 cm; patients under 18; pregnant or lactating women; women at the childbearing age; photossensitive diseases.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:35
RBR-9x6yxbv	Characterization of patients and evaluation of drug treatment for Multiple Sclerosis	Data analysis completed	Observational	2021-12-29	<NULL>	<NULL>	7986	Epidemiology and oral disease-modifying therapies for Multiple Sclerosis	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-9x6yxbv	<NULL>	Individuals over 18 years of age; of both sexes; diagnosed with Multiple Sclerosis represented by the G-35 code, which encompasses the group of diseases of the nervous system in the 10th edition of the International Statistical Classification of Diseases and Related Health Problems (ICD 10); assisted by the Specialized component of the Pharmaceutical Assistance of Mato Grosso do Sul; undergoing treatment, for at least three months, with one of the following oral administration medications: Teriflunomide 14mg, Dimethyl fumarate 240mg or Fingolimod 0.5mg; with at least one result of the Expanded Disability Status Scale (EDSS) prior to and one subsequent to the initiation of treatment with the oral medications described above	Individuals with cognitive alterations that make it difficult to remember facts related to their illness; individuals with cognitive alterations that make it difficult to understand the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:22:40
RBR-6ry6358	Cardiopulmonary analysis in patients with Stroke sequelae	Recruiting	Observational	2021-12-28	<NULL>	<NULL>	5129	Pulmonary function analysis and autonomic nervous system in patients with Cerebrovascular Accident sequelae	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-09-08	Universidade Federal do Triângulo Mineiro - UFTM	Universidade Federal do Triângulo Mineiro - UFTM	https://ensaiosclinicos.gov.br/rg/RBR-6ry6358	<NULL>	This research will include male and female participants older than 18 years with subacute CVA (1-3 months after CVA)  and chronic (more than 6 months after CVA) and non sedentary healthy people, living in Uberaba&apos;s urban area.	The criterion for exclusion will be individuals with cognitive deficiency (examined with the Mini-Mental State Examination (MMSE)), individuals with lip apprehension difficulty, individuals with previous lung diseases, smokers and those who absent at any moment from the proposed assessment..	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-9jwcykc	Effects of Pilates with and without elastic resistance on health variables in postmenopausal women with low back pain	Data analysis completed	Intervention	2021-12-23	<NULL>	<NULL>	5128	Effects of the Pilates method on balance, gait, falls and IGF-1 related to activities of daily living in elderly women	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-9jwcykc	<NULL>	"postmenopausal woman; present non specific chronic low back pain; low back pain for more than three months;  
no history of engagement in physical exercise during the previous three months"	be on hormone replacement therapy or analgesics; practice other types of exercises or treatments during the experiment	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-69hwsrt	Effect of Self the Care stimulation on family caregivers of patients in a home care program	Suspended	Intervention	2021-12-22	<NULL>	<NULL>	5125	Effect of the Inciting Self the Care intervention on family caregivers of patients linked to a home care program: a randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Federal de Pelotas	Universidade Federal de Pelotas	https://ensaiosclinicos.gov.br/rg/RBR-69hwsrt	<NULL>	Primary family caregiver of a patient with a chronic condition treated by the Home Care Program; resident in Pelotas in Rio Grande do Sul; age greater than or equal to 18 years; minimum dedication of 12 hours a day to care; literate; communication in Portuguese.	Not being available to receive the care interventions; death of the person with chronic disease in care; have someone resident of the domicile with a positive result for coronavirus during the data collection period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-9zy2z5c	Impact of different hydration solutions on the blood glucose of diabetic patients undergoing surgery	Recruiting	Intervention	2021-12-22	<NULL>	<NULL>	5127	Impact of perioperative fluid therapy on glycemia of patients with Diabetes Mellitus – Ringer&apos;s Lactate Solution versus Normal Saline Solution: prospective, randomized and controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-15	Complexo Hospitalar Santa Genoveva	Uberlândia Medical Center	https://ensaiosclinicos.gov.br/rg/RBR-9zy2z5c	<NULL>	Diagnosis of Diabetes Mellitus; Physical status of the American Society of Anesthesiologist (ASA) II and III; male or female; aged between 18 and 65 years; undergoing elective videolaparoscopic cholecystectomy under general anesthesia	Patients with poorly controlled blood glucose levels (blood glucose higher than 250 mg/dL); impaired kidney or liver function; ischemic heart disease; ongoing infection; patients receiving corticosteroid therapy. Exclusion criteria after randomization will be: protocol violation; major surgical complication (hemorrhage, hollow visceral perforation); presence of ongoing cholecystitis; cardiovascular or respiratory adverse event requiring admission to the Intensive Care Unit; or patient request	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-9dyq9jr	Pharmaceutical guidelines on the characteristics of prescription drug treatment for elderly people with heart-risk diseases	Not yet recruiting	Intervention	2021-12-21	<NULL>	<NULL>	5123	Intervenções farmacêuticas sobre a complexidade da farmacoterapia em Idosos com doenças de risco cardiovascular: um ensaio clínico randomizado, controlado	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-01	Fundação Universidade Federal de Sergipe	Fundação Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-9dyq9jr	<NULL>	Be 60 years of age or older; Carry out outpatient follow-up by outpatient physicians; Have at least one of the following diagnosed clinical conditions: systemic arterial hypertension, diabetes mellitus and dyslipidemia, according to the criteria recommended by the Brazilian guidelines for these clinical conditions; Present uncontrolled blood pressure and/or glycemic and/or lipid levels in accordance with established goals for the level of cardiovascular risk; Use medication for at least one of the chronic conditions mentioned above for more than six months	Diagnosis of resistant or secondary systemic arterial hypertension; Diabetes and/or secondary dyslipidemia; End stage of kidney disease; Liver disease; Cancer treatment; Acquired immunodeficiency syndrome or anticoagulation; Unstable psychiatric illness; Service provided by other pharmacists; Inability to attend scheduled appointments; Missing in more than two consecutive appointments; Withdrawal from participating in the study at any stage	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-7g9jtsm	The effectiveness of Biofeedback and Therapeutic Exercise on symptoms related to Tooth Clenching while awake	Not yet recruiting	Intervention	2021-12-20	<NULL>	<NULL>	5119	Effectiveness of Biofeedback and Therapeutic Exercise on fatigue, pain and mandibular function in subjects with Awake Bruxism: randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Federal de Pernambuco	Universidade Federal de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-7g9jtsm	<NULL>	Men and women between the ages of 18 and 45; Diagnosis of awake bruxism or diagnosis of both awake bruxism and sleep bruxism by a dentist; Complaints of pain or discomfort in the facial region for at least 3 months (chronic pain); Report of clenching or grinding of teeth while awake in the last 3 months	Presence only of sleep bruxism; History of facial trauma, rheumatic, neurological and orthopedic pathologies; Surgical procedures performed in the craniocervical region; Use of orthodontic appliance during the treatment period and removal of the same less than 3 months before the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-2twzy65	The effect of different exercise models on elderly people with knee osteoarthritis	Recruitment completed	Intervention	2021-12-20	<NULL>	<NULL>	5120	Effects of different exercise models with and without blood flow restriction on strength, muscle mass, functionality and pain perception in patients with knee osteoarthritis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-10	Universidade São Judas	Grupo de estudos e pesquisa em restrição do fluxo sanguíneo e exercício	https://ensaiosclinicos.gov.br/rg/RBR-2twzy65	<NULL>	Patients of both sexes, aged over 60 years, functional independence, diagnosed with knee osteoarthritis; patients with medical referral for physical therapy treatment; absence of severe cardiovascular or musculoskeletal diseases	Patients with knee arthroplasty, contraindication for the use of pressure cuffs or tourniquets, with peripheral vascular disease, who use anticoagulants, will be excluded; history of deep vein thrombosis, congenital lower limb malformations, diagnosis of fibromyalgia; contraindication to exercise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-3272v32	Use of red laser and chamomile in the treatment of oral ulcers in children and adolescents with cancer	Recruitment completed	Intervention	2021-12-20	<NULL>	<NULL>	5121	Use of photobiomodulation and chamomile in the treatment of oral mucositis in children and adolescents with cancer: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2019-11-01	Universidade Federal de Pernambuco	Hospital Universitário Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-3272v32	<NULL>	Children e adolescents aged 0 to 18 years; with cancer; undergoing chemotherapy/radiotherapy treatment; with oral mucositis greater than or equal to 2, according to the toxicity criteria of the World Health Organization (HUNTER, 1980)	Those included with a malignant neoplasm or severe infection (pseudomembranous candidiasis, herpes, etc.) clinically evident in the oral cavity; with solid tumors in the mouth or oropharynx; or in a serious situation that will prevent participation in the research will be excluded from the sample; in addition to these having allergic reactions to the composition of chamomile.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-3xbpwqy	Innovations in placental metabolism and association with antioxidants and nutrients in gestational diabetes and obesity	Suspended	Observational	2021-12-20	<NULL>	<NULL>	5122	Impacting: Innovations in Placental Metabolism and Association with Antioxidants and Nutrients in Gestational Diabetes and Obesity	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2017-07-20	Maternidade Escola da Universidade Federal do Rio de Janeiro	Maternidade Escola da Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-3xbpwqy	<NULL>	Pregnant women with between 18 and 45 years; with beginning the follow-up at Maternidade Escola, Universidade Federal do Rio de Janeiro until 20 gestational weeks; chronic non transmissible diseases-free, except obesity; infectious diseases-free; gestating single fetus; with intention to deliver at the Maternidade Escola, Universidade Federal do Rio de Janeiro	Pregnant women smokers; with low weight in early pregnancy calculated by the Body Mass Index, less than 18.5 kilograms per square meter.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-10jgv7ky	The emotions of college students: the application of the practice of Hatha Yoga	Recruitment completed	Intervention	2021-12-20	<NULL>	<NULL>	5518	Emotional indicators of college students: an intervention study with Hatha Yoga	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-02	Universidade Federal de Mato Grosso - UFMT	Faculdade de Enfermagem (FAEN)	https://ensaiosclinicos.gov.br/rg/RBR-10jgv7ky	<NULL>	Healthy individuals; both genders; actively enrolled in Undergraduate Nursing, Medicine, Nutrition and Psychology courses	Indivíduos com dificuldades de deambulação grave; deficiência motora e/ou doenças musculoesqueléticas; com acompanhamento paralelo de fisioterapia ou outro acompanhamento semelhante; gestante; cirurgia recente; hérnia diagnostica; hemorróidas agudas com sangramento; hipertensão arterial sistêmica grave; asma grave; tosse crônica; glaucoma; idade inferior a 18 anos completos; ideação suicida nos últimos 30 dias; em psicoterapia e/ou qualquer tipo de prática integrativa continuamente; em uso de medicação psicotrópica; cursando o último ano ou semestre do curso matriculado	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:10
RBR-47yx6p9	Use of Ginger to control nausea and vomiting caused by chemotherapy in patients with cervical cancer undergoing treatment: an experiment	Recruiting	Intervention	2021-12-16	<NULL>	<NULL>	5116	Use of Ginger (Zingiber Officinale) in the management of chemotherapy-induced nausea and vomiting in patients with cervical Cancer undergoing antineoplastic treatment: a randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Liga Norte Riograndense Contra o Câncer	Liga Norte Riograndense Contra o Câncer	https://ensaiosclinicos.gov.br/rg/RBR-47yx6p9	<NULL>	Over 18 years old; have a diagnosis of cervical cancer with histological confirmation; have an indication for treatment with cisplatin 40mg/m² weekly associated with radiotherapy; preserved capsule swallowing capacity	Have a history of hypersensitivity to ginger; pregnancy or breastfeeding; have another primary neoplasm; ongoing chemotherapy treatment; having undergone previous antineoplastic and/or radiotherapy treatment; radiotherapy treatment in the epigastric region of the abdomen; surgery scheduled during the study period; have any feeding device (nasoenteric tube, gastrostomy, or jejunostomy); in simultaneous use of a supplement or ginger-based foods; using anticoagulants; have a history of bleeding disorders (severe thrombocytopenia), hyperthyroidism, and heart disease; a pre-existing condition causing nausea and vomiting.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-8xxyrt8	Influence of hippotherapy on postural balance, gait and communication in children with Cerebral Palsy or Down Syndrome	Recruitment completed	Intervention	2021-12-16	<NULL>	<NULL>	5117	Influência da equoterapia sem equilíbrio postural, na marcha e na comunicação em crianças com Paralisia Cerebral ou com Síndrome de Down	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-03-03	Leandra Aparecida Leal	Universidade de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-8xxyrt8	<NULL>	Have a medical diagnosis of Cerebral Palsy with indication to the practice of hippotherapy through appropriate assessment. Be from 4 to 14 years old. Possess cognitive ability to respond satisfactorily to the requested commands so that they are able to participate in data collection. Remain in the bipedal orthostatic position without wearing shoes or orthoses for 20 seconds and have independent gait without using devices due to the data collection procedure. Have hip abduction of at least 20 degrees to remain seated on the horse.	Have undergone any surgical procedure in the last 12 months or are planning any surgery for the period of the research. Have performed neuromuscular chemical blockade less than 6 months ago or are planning to perform it during the research period. Possess uncorrected visual deficit. Having uncontrolled seizures, Hip dislocation, excessive adductor contracture and severe osteoporosis or any other reason preventing horse riding, such as excessive fear. If they don&apos;t have at least 75% of frequency in the hippotherapy sessions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-6nb6s76	Effects of physical therapy intervention and health education in the preparation for childbirth of Brazilian pregnant women	Recruiting	Intervention	2021-12-16	<NULL>	<NULL>	5118	Effects of physical therapy intervention and health education in the preparation for childbirth of Brazilian pregnant women	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-31	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-6nb6s76	<NULL>	Healthy pregnant women; over 18 years	Pregnant women at risk	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-9tqr2jt	Effectiveness of Exercise In Neck Pain due to Whiplash Associated Disorders	Not yet recruiting	Intervention	2021-12-15	<NULL>	<NULL>	5112	Exercise-Induced Hypoalgesia in Acute/Subacute Whiplash Associated Disorders: a randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	University of Seville	University of Seville	https://ensaiosclinicos.gov.br/rg/RBR-9tqr2jt	<NULL>	Inclusion criteria are aged between 18-65 years, have sustained a whiplash injury within the last 7 and 30 days, diagnosis of WAD grade IIaccording to Quebec Task Force	Exclusion criteria are WAD grade I, III or IV injury (neurological deficit, fracture or dislocation), presence of previous generalized pain or neuropathic pain condition, nerve root compromise (at least 2 of the following signs: weakness/reflex changes/sensory loss associated with the same spinal nerve), loss of consciousness after the accident, instability signs, psychiatric disorders, inflammatory or rheumatic disease, or tumours, previous surgery in the cervical or upper limbs region, previous whiplash injury, unwilling to perform a prescribed exercise intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-62nn2w4	Color evaluation of different aesthetic elastics submitted to mouthwash with and without alcohol.	Recruitment completed	Intervention	2021-12-15	<NULL>	<NULL>	5114	Color evaluation of different aesthetic orthodontic ligatures submitted to mouthwashes with and without alcohol.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-08-20	Fundação Hermínio Ometto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-62nn2w4	<NULL>	Volunteers undergoing orthodontic treatment who have conventional orthodontic appliance with rubber band ligation; Patients with good oral hygiene; At least five teeth present in each arch.	Patients who have self-ligating devices; periodontal problems; patients with systemic diseases or cleft lip and palate; use of medications (antibiotics or anti-inflammatory drugs up to 30 days before the study); smoker or ex-smoker; pregnant or breastfeeding; patients allergic to the components of the mouthwash formula.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-5hvgtky	Effectiveness of nutritional intervention to management Systemic Arterial Hypertension in Primary Health Care	Not yet recruiting	Intervention	2021-12-15	<NULL>	<NULL>	5115	Nutritional intervention to control Systemic Arterial Hypertension in Primary Health Care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-03	Universidade Federal de Ouro Preto	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-5hvgtky	<NULL>	Both sexes; over 20 years old	Volunteers with cardiovascular disease, angina, heart attack, heart failure, atherosclerosis, peripheral vascular disease, ischemic cerebrovascular disease, chronic liver, kidney or infectious diseases evaluated by medical history; 10% change in body weight two months prior to the study; use of anti-inflammatory drugs; women on exogenous ovarian hormone replacement, pregnancy or breastfeeding; people with special needs; Alzheimer&apos;s disease, dementia or life expectancy shorter than study duration; cognitive difficulties.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-2394x96	Guided regeneration with polydioxanone membrane (PDO) in dental alveoli after extraction: volumetric analysis	Not yet recruiting	Intervention	2021-12-15	<NULL>	<NULL>	5126	Comparative, prospective and randomized clinical study of guided regeneration with Polydioxanone membrane (PDO) in dental alveoli after extraction: volumetric analysis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-01	M3 Health Indústria e Comércio de Produtos Médicos, Odontológicos e Correlatos Sociedade Anônima	Faculdade de Odontologia de Araraquara	https://ensaiosclinicos.gov.br/rg/RBR-2394x96	<NULL>	Patients must have all four bone walls after the extraction procedure; over 18 years old; who have signed the informed consent form	Uncontrolled systemic commitments; teeth in areas of tumor lesions; acute infectious processes; deciduous dental elements; untreated periodontal problems; smokers; radiated in the head or neck region; allergy to any component used in the research; psychological disorders; pregnant and lactating women	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:54
RBR-9qss9jn	Importance of continuous oxygen monitoring during the six-minute walk test in patients with chronic respiratory diseases	Recruiting	Observational	2021-12-14	<NULL>	<NULL>	5106	Importance of continuous pulse oximetry monitoring during the six-minute walk test in predicting clinical outcomes and safety in patients with chronic respiratory diseases	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-03-01	Hospital de Clinicas de Porto Alegre (HCPA)	Universidade Federal do Rio Grande do Sul (UFRGS)	https://ensaiosclinicos.gov.br/rg/RBR-9qss9jn	<NULL>	Individuals of both genders; over 18 years of age; with chronic respiratory disease; who have a request from the assistant physician to perform the six-minute walk test at the Pulmonary Physiology Unit of the Hospital de Clinicas de Porto Alegre (HCPA)	Individuals with contraindications for performing the six-minute walk test; those who performed at least one six-minute walk test in the 3 months prior to inclusion; which weather conditions that standard pulse oximetry signal in the resting measurement at the beginning of the six-minute walk test	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-3skc59k	Nem method to assess the functional capacity in people with chronic obstructive pulmonary disease	Recruiting	Intervention	2021-12-14	<NULL>	<NULL>	5107	Nem method to assess the functional capacity in people with chronic obstructive pulmonary disease	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-02-05	Escola de Educação Física da Universidade Federal de Minas Gerais	Escola de Educação Física da Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-3skc59k	<NULL>	Had diagnosis of chronic obstructive pulmonary disease, asthma, intersticial lung diseases, bronchiectasis, occupational diseases, pulmonary hypertension, and allergenic status; were stable over the past month and sign the written informed consent	Self-reported concomitant cardiovascular, orthopaedic or neurological conditions that were likely to impair exercise performance; body mass index over 35 kg/m2; diagnosis of major psychiatric illness; incapacity to give the informed consent; incapacity to understand or perform the tests of the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-299z6qr	Rehabilitation Program for people after COVID-19 infection	Not yet recruiting	Intervention	2021-12-14	<NULL>	<NULL>	5108	Rehabilitation after Covid-19: Implementation and evaluation of a rehabilitation and case monitoring program	<NULL>	n/a, n/a, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Estadual da Paraíba	Universidade Estadual da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-299z6qr	<NULL>	Volunteers aged between 18 and 70 years, of both genders;  have been diagnosed (by laboratory tests) with COVID-19;  be outside the acute phase of the disease; present need for rehabilitation; not present neurological or cognitive deficits that interfere in the performance of any of the proposed activities.	Patients who voluntarily require the study to leave; not adapt to the proposed protocols; missing more than 3 consecutive sessions without justification; who have cardiovascular, respiratory or neurological alterations that compromise the performance of the proposed rehabilitation activities and that configure the need for medical evaluation for possible evaluations of the presented conditions.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-24z8q24	The influence of Pilates on the strength and functionality of the elderly	Data analysis completed	Intervention	2021-12-14	<NULL>	<NULL>	5109	Biological, behavioral and sociocultural analysis in adults and elderly individuals who practice physical exercises	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-03-20	Universidade Federal de Santa Maria	Universidade Federal de Santa Maria	https://ensaiosclinicos.gov.br/rg/RBR-24z8q24	<NULL>	Being between 60 and 79 years of age; not having been practicing physical exercises for at least six months; presenting a medical certificate claiming to be fit for Pilates, presenting a score less or equal 14 points in the Clinical-Functional Vulnerability Index-20 classified as elderly with moderate risk of clinical-functional vulnerability	Neurological; cardiovascular; respiratory and orthopedic diseases that prevent Pilates exercises; smoking habits; wheelchair use; frequency of less than 75% in classes during the time proposed for the established training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-274vf96	Effectiveness of in-office dental bleaching in adolescents using 6% hydrogen peroxide with different application tips	Recruitment completed	Intervention	2021-12-14	<NULL>	<NULL>	5110	Effectiveness of in-office dental bleaching in adolescents using 6% hydrogen peroxide with different application tips: randomized double-blind clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-12	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-274vf96	<NULL>	Age between 12 and 16 years old; good general and oral health; healthy vital teeth; minimum color A2; their guardians agree and sign the informed consent form (TCLE).	Previously bleaching procedure; prior dental sensitivity; dental prosthesis; fixed orthodontic appliance; restorations in the upper anterior teeth; presence of deciduous teeth; endodontic treatment of maxillary anterior teeth; gingival recessions; teeth stained by tetracycline or fluorosis; visible cracks in teeth; continuous use of medications; pregnant or lactating women; bruxism; smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-6wy5y4t	Effects of Trunk-Specific Exercise on Pain, Inflammation, and Hormonal Release in Women with Back Pain	Data analysis completed	Intervention	2021-12-13	<NULL>	<NULL>	5099	Acute neuroimunoendocrin effects of high and low volume core training in women with unspecific chronic low back pain: a crossover study	<NULL>	4, non-randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2019-10-01	Universidade Federal de Sergipe	Universidade Federal de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-6wy5y4t	<NULL>	Women will be included in the research with a clinical diagnosis of nonspecific chronic low back pain, between 18 and 40 years old, who have complained of low back pain for more than 3 months, with a pain level between 3 and 6 on the Numeric Pain Rating Scale (NRS) (COSTA, et al. 2008). The volunteers will need to present a body mass index (BMI &lt;30 kg/cm2); not being pregnant; not having given birth for less than three months; not having undergone any surgery on the spine; not having performed any type of exercise in the last three months; not being undergoing any type of pain treatment; and without the use of analgesic, anti-inflammatory, opioid or immunosuppressive medication.	Participants who miss one of the days of the tests or who have any psychiatric or cognitive impairment, hearing, visual or communication disorders that make it impossible to carry out the protocol will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-10cr49dr	Analysis of foraminal patency attainment rates by undergraduate students - An &quot;in vivo&quot; Study	Data analysis completed	Intervention	2021-12-13	<NULL>	<NULL>	5100	Analysis of foraminal patency attainment rates by undergraduate students - An &quot;in vivo&quot; Study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2015-03-12	Universidade Paranaense	Universidade Paranaense	https://ensaiosclinicos.gov.br/rg/RBR-10cr49dr	<NULL>	Patients with one or more dental elements indicated for radical endodontic treatment; complete rhizogenesis	Dental elements with previously performed endodontic treatments; root curvatures; root resorption processes; anatomical complexities	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-97rb5wk	Physiotherapy for Women After Gynecologic Pelvic Cancer Treatment.	Not yet recruiting	Intervention	2021-12-13	<NULL>	<NULL>	5101	"Rehabilitation Program of Pelvic Floor 
Post-Surgery and Radiotherapy
for Gynecological Pelvic Cancer: Randomized and Controlled Clinical Trial."	<NULL>	1-2, randomized-controlled, single-blind	1-2	<NULL>	<NULL>	<NULL>	2022-02-01	Faculdade de Medicina de Ribeirão Preto	Centro de Pesquisa Oncologica	https://ensaiosclinicos.gov.br/rg/RBR-97rb5wk	<NULL>	Age group older than 18 years; Clinical staging I to III of pelvic gynecological cancer; Having undergone surgery, radiotherapy, and/or brachytherapy;  Have urinary incontinence;  Do not present any orthopedic or neurological limitations that prevent the practice of the rehabilitation program; Not being under physiotherapeutic treatment.	Withdrawal of the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-79ttm4m	Creation of an assessment score for small, medium and large joints, through joint ultrasound examination in patients with rheumatoid arthritis	Recruitment completed	Observational	2021-12-13	<NULL>	<NULL>	5103	Joint ultrasound in patients with rheumatoid arthritis: development of an evaluation score using small, medium and large joints.	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-07-01	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-79ttm4m	<NULL>	Rheumatoid arthritis for more than 1 year, according to the ACR criteria (Arnett, Edworthy et al. 1988); Age between 30 and 60 years, stratified in the following age groups: 30 to 39 years: 33.3%, 40 to 49 years: 33.3% and 50 to 60 years: 33.3%; Female and male sex, in the proportion of three women for each man; Have accepted to participate in the previous study and signed the free and informed consent form for the study from which we used the data.	"Diagnosis of diabetes mellitus; Diagnosis of hypothyroidism; Diagnosis of hemophilia; Suspected pregnancy, current pregnancy or until the 6th month of postpartum; Women in active lactation; History of trauma in the studied joints; History of septic arthritis in the joints studied.
History of surgery on the joints studied.
Symptomatic osteoarthritis in the studied joints.
Severe joint deformities.
Overlap with another collagen.
Corticosteroid infiltration in any joint to be studied for less than 6 months.
Corticosteroid infiltration into any joint that has not been studied for less than 1 month."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-7z3kxjk	Physical training program and its effects on inflammatory, respiratory, quality of life, biochemical and health levels.	Recruiting	Intervention	2021-12-13	<NULL>	<NULL>	5104	Rehabilitation and monitoring of the effects of the clinical evolution of patients infected with the new Corona virus 2019 (sars-cov-2) associated with non-transmissible chronic diseases submitted to a supervised physical exercise program: immunological factors, cardiorespiratory function, microbiota and quality of life	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-08-05	Universidade Federal de Pernambuco	Hospital das clinicas	https://ensaiosclinicos.gov.br/rg/RBR-7z3kxjk	<NULL>	Adults; both sexes; who developed COVID-19; confirmation of COVID-19 infection; hypertensive, obese, diabetes, heart disease, nephrology, cancer and HIV/AIDS; with medical discharge and not having limitations to perform the physical fitness test and intervention protocol.	Individuals who did not reach the cutoff points on the Mini-Mental State Examination (MMSE); individuals with physical limitations; hospitalized in the last 12 months prior to COVID-19 infection; decompensated heart failure and chronic obstructive pulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-8p36d5m	The Effects of Transcranial Photobiomodulation in Adults with Mild Cognitive Impairment	Not yet recruiting	Intervention	2021-12-13	<NULL>	<NULL>	5105	The Impact of Transcranial Photobiomodulation on Adult Mild Cognitive Impairment: A Double-Blind Randomized Controlled Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade do Sul de Santa Catarina	Universidade do Sul de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-8p36d5m	<NULL>	Individuals of both sexes, with a diagnosis of Mild Cognitive Impairment will be included in this study	Individuals with epilepsy; hypersensitivity to light; with immunodepressive; oncological; infectious diseases or with characteristic symptoms of suspected COVID-19 infection; or confirmation of COVID-19 by test; pregnant or lactating women will be excluded from this study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-5y9y7p7	Safety and Immunogenicity of heterologous or homologous booster after complete vaccination against COVID-19.	Recruiting	Intervention	2021-12-13	<NULL>	<NULL>	5178	Safety and Immunogenicity of heterologous or homologous booster after complete vaccination against COVID-19.	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-10-20	Secretaria Municipal de Saúde do Rio de Janeiro	Fundação Osvaldo Cruz - Fiocruz	https://ensaiosclinicos.gov.br/rg/RBR-5y9y7p7	<NULL>	"Age 18 years or older;
Have completed the primary vaccination course against COVID-19 with the Coronavac/Butantan, AstraZeneca/Fiocruz or Pfizer vaccines for at least three months;
Accepting to participate in the study by signing the Informed Consent Form (ICF);"	"Uncontrolled chronic illness (defined as illness that required a significant change in therapy or hospitalization for worsening illness during the 3 months prior to inclusion);
Individuals with any severe or progressive neurological disorder, difficult to control seizure disorder or a history of Guillian-Barré syndrome or demyelinating diseases of the central nervous system;
Individuals with congenital or acquired immunodeficiency*; or individuals who have received treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, e.g. eg, for cancer or an autoimmune disease, within the last 12 months or planned receipt during the study period. If a short-term course (&lt; 14 days) of systemic corticosteroids has been for the treatment of an acute illness, participants should not be included in the study until corticosteroid therapy has been discontinued for at least 30 days prior to the study. A single dose of systemic steroids in a single day is allowed, as well as inhaled/nebulized, intra-articular, intrabursal or topical (skin or eyes) corticosteroids are allowed;
Participants who report pregnancy in progress or planning to become pregnant within the next 60 days after inclusion in the study; and postpartum women (up to 45 days after delivery). In the case of women of childbearing age, with an active sexual life and without consistent use of contraceptives, at the researcher&apos;s discretion, the participant may be excluded or, alternatively, included, if she agrees to use contraceptives for a period of 60 days after inclusion . In these cases, if necessary, the contraceptive will be provided by the responsible researcher free of charge;
Blood transfusion or use of blood products in the last 6 months;
Having had a heterologous primary vaccination schedule against Covid-19;
Have received a higher number of doses than currently recommended for Covid-19;
Having had a serious adverse event to any formulation of the Covid-19 vaccine;
Hypersensitivity to the active ingredient or to any of the excipients of the Covid-19 vaccines used in the study;
Any condition that, in the investigator&apos;s opinion, could compromise the follow-up of the study.
* Individuals with HIV infection can be included as long as they have been on regular antiretroviral therapy for at least 3 months, with an undetectable viral load in the last 12 months and CD4 &gt; 350 cells/mm3 at the last exam.
Criteria for postponing vaccination, with subsequent reassessment, should be considered:
Individuals with acute, mild febrile illnesses until they are 72 hours without fever;
Individuals diagnosed with COVID-19 within 4 weeks of symptom onset;"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:56
RBR-87pc5z9	Effects of auriculotherapy on musculoskeletal pain in elementary school teachers	Data analysis completed	Intervention	2021-12-10	<NULL>	<NULL>	5095	Effects of auriculotherapy on musculoskeletal disorders in elementary school teachers	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Tiago Veloso Neves	Fundação Escola de Saúde Pública de Palmas	https://ensaiosclinicos.gov.br/rg/RBR-87pc5z9	<NULL>	The study included teachers of all ages and genders, who had musculoskeletal disorders and who agreed to participate in the study by signing the Informed Consent Form (FICF).	Teachers who did not have musculoskeletal disorders, who were on sick leave, maternity leave, vacation, medical certificate, and/or refused to participate in the research, and people who had an allergy to adhesive tape were excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-6srzwwm	Local and systemic reaction of antimicrobial gel: a randomized clinical trial	Recruiting	Intervention	2021-12-10	<NULL>	<NULL>	5096	Dermal tolerability and systemic toxicity of antimicrobial gel for topical use	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2021-11-08	Programa de Pós Graduação em Enfermagem da Universidade Federal de Alagoas	Unidade Docente Assistencial Prof. Gilberto de Macedo (UDA/UFAL)	https://ensaiosclinicos.gov.br/rg/RBR-6srzwwm	<NULL>	Older than 18 years; Faculty and students from the Nursing Undergraduate Course at the Nursing School of the Federal University of Alagoas; User population of the health unit where the research will be carried out; People willing to attend daily follow-up appointments during monitoring.	Presence of any change in the baseline results of laboratory tests; Previous skin alteration at the right or left forearms; Declarants of any underlying pathology, requiring daily or regular use of medication; Reporters of dermal hypersensitivity; Possessors of cognitive alterations; Pregnant women; Alcoholics.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-105c46mj	The Effect of a Home Exercise Program for the prevention of Falls in the elderly	Recruiting	Intervention	2021-12-10	<NULL>	<NULL>	5097	Efficacy of a Home Exercise Protocol for preventing Falls in elderly people living in the rural area of the city of Rio Grande, RS: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-08	Universidade Federal do Rio Grande	Núcleo Municipal de Educação em Saúde Coletiva	https://ensaiosclinicos.gov.br/rg/RBR-105c46mj	<NULL>	People aged 60 or over, living in the areas covered by the Basic Family Health Units in the city of Rio Grande, Rio Grande do Sul, Brazil, will be included. With medical clearance to participate in the intervention; and with the ability to understand directions.	Previous diagnosis of dementia or cognitive decline that compromises the understanding of guidelines and intervention; Stroke with severe neurological damage, such as loss of strength, sensitivity and language limitations; Progressive neurological disease such as Parkinson&apos;s Disease; Visual impairment; dizziness or vertigo; participate in an exercise program or in physical therapy treatment; Inability to stand and walk independently; Another motor disability that incapacitates the participant to perform physical exercise.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-65tj6zq	Effect of educational video to guide parents and caregivers of children in clean intermittent catheterization: a randomized clinical study	Recruiting	Intervention	2021-12-10	<NULL>	<NULL>	5098	Effectiveness of an educational video to guide parents and caregivers of children in clean intermittent catheterization: a randomized clinical trial	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-06-14	Departamento de Enfermagem - Universidade Federal do Ceará	Hospital Infantil Albert Sabin	https://ensaiosclinicos.gov.br/rg/RBR-65tj6zq	<NULL>	Volunteers of both genders; literate; being parents or caregivers of children diagnosed with diseases that lead to the use of Intermittent Urethral Catheterization.	Parents or caregivers who have some kind of apparent condition that compromises child care actions; non-attendance at the stages of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-8q96hsh	Comparison between two types of ergonomic adjustments in cycling	Data analysis completed	Intervention	2021-12-09	<NULL>	<NULL>	5093	Comparison Between 3D Kinematic Bikefitting and Traditional Bicycle Adjustment Recommendations: A Double-Blind Randomized Controlled Trial	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2020-09-07	Universidade Cidade de Sao Paulo	Universidade Cidade de Sao Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8q96hsh	<NULL>	amateur ciclists	continuous use of painkillers; ride with proposed bike setup	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-5zgy25w	Effect of a non-drug intervention on pain and anxiety during influenza vaccination	Not yet recruiting	Intervention	2021-12-09	<NULL>	<NULL>	5094	Effect of a non-pharmacological intervention on pain and anxiety related to the administration of influenza vaccine in adults: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-03-07	Departamento de Medicina e Enfermagem da Universidade Federal de Viçosa	Departamento de Medicina e Enfermagem da Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-5zgy25w	<NULL>	Age 18 years and over; both sexes; preserved cognition; be literate; receive only injection of the influenza vaccine via IM in the deltoid region	Participants reporting pain in the upper limbs; presence of injury or abrasions in the deltoid region; loss or alteration of sensation in the upper limbs, previous use of analgesics in the last six hours prior to immunization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-9x5whvf	Effect of tomato supplementation on oxidative stress and cardiac function in hemodialysis patients	Data analysis completed	Intervention	2021-12-08	<NULL>	<NULL>	5085	Effect of tomato (Lycopersicon esculentum) supplementation on oxidative stress markers and cardiovascular function in patients with chronic kidney disease treated by hemodialysis	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-01	Faculdade de Medicina de Botucatu UNESP	Faculdade de Medicina de Botucatu UNESP	https://ensaiosclinicos.gov.br/rg/RBR-9x5whvf	<NULL>	Patients older than 18 years old and prevalent in chronic HD for at least three months were included;	Patients with cancer, HIV-positive undergoing antiretroviral therapy, end-stage liver disease, heart failure disease with ejection fraction less than 30%, clinical diagnosis of acute infection, (or using antibiotics), chronic inflammatory diseases, such as systemic lupus erythematosus and chronic obstructive pulmonary disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-5sv27rh	Videosurgery or fibrinolysis for the treatment of pleural empyema in children admitted to intensive care unit	Not yet recruiting	Intervention	2021-12-08	<NULL>	<NULL>	5086	Pleural empyema in children admitted to the Icu: Clinical trial comparing fibrinolysis and videosurgery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Hospital Infantil Joana de Gusmão	Hospital Infantil Joana de Gusmão	https://ensaiosclinicos.gov.br/rg/RBR-5sv27rh	<NULL>	Children with parapneumonic empyema and chest ultrasound with signs of high-grade empyema (gross septations, pleural thickening, pleural fluid hyperechogenicity) were admitted to the intensive care unit before treatment.	". Participants with contraindications to performing any procedure;
. Participants with hydropneumothorax in the pleural space, these findings that indicate video surgery as the treatment of choice;
. Medical record not filled out or incompletely filled out; and
. Unavailability of material for video surgery or fibrinolysis."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-87g6ny8	Effect of resveratrol combined on Exercise program on health-related outcomes of breast cancer survivors: randomized, double-blind clinical trial	Data analysis completed	Intervention	2021-12-08	<NULL>	<NULL>	5087	Effect of resveratrol combined on Exercise program on health-related outcomes of breast cancer survivors: randomized, double-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-02-01	Universidade Federal de Pernambuco	Fundação de apoio à Ciência e Tecnologia de Pernambuco - FACEPE	https://ensaiosclinicos.gov.br/rg/RBR-87g6ny8	<NULL>	"Postmenopause; 
high BMI; 
sedentary lifestyle (mild physical activity, less than 150 minutes per week, American College of Sports Medicine 2014)"	"Recurrence of breast cancer;
 bone metastasis; 
bone fractures; 
severe anemia; 
platelet count less than 50x109ml; 
participation in other physical exercise programs."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-82zbbb2	Brain alterations in adolescents and adults victims of sexual abuse	Recruitment completed	Intervention	2021-12-08	<NULL>	<NULL>	5088	Brain Connectivity and Neuroprogression. Multimodal MRI approach in victims of sexual abuse (adolescents and adults) with Post Traumatic Stress Disorder	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2017-10-10	Universidade Federal de São Paulo	Columbia University	https://ensaiosclinicos.gov.br/rg/RBR-82zbbb2	<NULL>	Case: have been victims of sexual violence; age between 14 and 17 years; to have Post traumatic stress disorder (PTSD) diagnosis after the application of the  Clinician administered PTSD scale for children and adolescents (CAPS CA) performed in the screening; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficit. Controls: did not present psychiatric diagnoses through the scale Schedule for Affective Disorders and Schizophrenia for School-Aged Children (K-SADS) , did not have a traumatic event of sexual violence through the CAPS-CA scale; do not present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; do not present decompensated clinical diseases that require intensive treatment; do not present significant intellectual deficits; absence of use of psychoactive substances in the last 6 months; not being pregnant; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficits , intelligence coeficient( IQ)below 70.	Case: present psychiatric diagnoses prior to the traumatic event of sexual violence; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; Pregnancy detected through blood test.Controls: present psychiatric diagnoses; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery;  presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; pregnancy detected through blood test; have been sexually abused.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-10j9738z	Effect of a sleep-facilitating dietary orientation in women undergoing breast cancer treatment	Recruiting	Intervention	2021-12-08	<NULL>	<NULL>	5089	Analysis of the effect of dietary guidance that facilitates sleep in women undergoing breast cancer treatment	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Federal de Juiz de Fora	Universidade Federal de Juiz de Fora	https://ensaiosclinicos.gov.br/rg/RBR-10j9738z	<NULL>	Women undergoing chemotherapy; who do not have another type of cancer concomitantly	Women with intolerance to foods that facilitate sleep; who use a pacemaker; who present digital illiteracy; and those who do not accept or do not meet the inclusion criteria	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-3q8syh4	Evaluation of gynecological and dermatological acceptability of health products using the product at home	Not yet recruiting	Observational	2021-12-08	<NULL>	<NULL>	5090	Evaluation of gynecological and dermatological acceptability of health products under normal conditions of use_Ave02.2021	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2022-03-21	Ipclin Instituto de Pesquisa Clínica Integrada Ltda	Avenca Indústria Cosmética Eireli -EPP	https://ensaiosclinicos.gov.br/rg/RBR-3q8syh4	<NULL>	Women; age: 18 to 59 years; phototype: I to IV; whole skin of the region; occasional user of category products	Skin marks in the experimental area that interfere with the assessment of possible reactions; Pregnant or lactating women; Participants with a history of allergy to the material used in the study; Atopy history; Use of vaginal cream; Participants with a history of allergy to products from the tested category; Recent gynecological surgeries; Discharges; Immunodeficiency patients; Kidney, cardiac or liver transplants; Active skin conditions that may interfere with the study (vitiligo, psoriasis, lupus, atopic dermatitis); Topical use with corticosteroids in the experimental area up to 8 days before the start of the study.; Any condition not mentioned above that, in the investigator&apos;s opinion, could compromise the study evaluation	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-4x36zqc	Intimacy in the psychotherapy of complex post-traumatic stress disorder	Recruitment completed	Intervention	2021-12-08	<NULL>	<NULL>	5091	The role of intimacy in the psychotherapeutic treatment of complex post-traumatic stress disorder	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-09-10	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina do EStado de São Paulo	Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina do EStado de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4x36zqc	<NULL>	"intervention group: age between 18 and 65 years; diagnosis of complex post-traumatic stress disorder; at least one specific memory for a traumatic event

control group: age between 18 and 65 years; at least one specific memory for a traumatic event; not fulfilling criteria for diagnosis of Posttraumatic Stress Disorder; not fulfilling criteria for diagnosis of primary psychotic disorder"	Diagnosis of primary psychotic disorder; changes in psychiatric medication in the two months preceding inclusion in the project	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-22ctkjq	Effects of using cell phone applications with and without therapeutic supervision on the ability to perform day-to-day activities in older adults	Recruitment completed	Intervention	2021-12-08	<NULL>	<NULL>	6349	Functional capacity of older people before and after the practice of physical activity performed through smartphone exercise applications with and without therapeutic supervision	<NULL>	n/a, randomized-controlled, n/a	N/A	<NULL>	<NULL>	<NULL>	2022-01-30	Universidade Nove de Julho	Universidade Nove de Julho	https://ensaiosclinicos.gov.br/rg/RBR-22ctkjq	<NULL>	Healthy volunteers; aged between 60 and 80 years; both sexes; sedentary; independent to perform activities of daily living; vaccinated against COVID-19.	Volunteers with cognitive impairment; presence of injuries, fractures or amputations of lower limbs; presence of neurological, vestibular or cardiovascular diseases; participating in other activity programs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:40
RBR-9wkvm5b	Benefits of non-invasive pulmonary ventilation soon after tube removal in the postoperative period of heart surgery	Data analysis completed	Intervention	2021-12-07	<NULL>	<NULL>	5083	Benefits of Non-Invasive Ventilation immediately after extubation in the Postoperative period of Cardiac Surgery	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-01-01	Faculdade Nobre de Feira de Santana	Faculdade Nobre de Feira de Santana	https://ensaiosclinicos.gov.br/rg/RBR-9wkvm5b	<NULL>	This study included patients of both sexes; aged 18 years or older; who underwent to coronary artery bypass grafting with median sternotomy and cardiopulmonary bypass.	Patients with hemodynamic instability before noninvasive ventilation; who were not cooperative or who had contraindications for the use of noninvasive ventilation; chronic pulmonary disease; absence of blood gas analysis in some of the study phases; physical limitations that compromised the performance of functional tests were excluded; difficulty understanding to perform the applied tests; surgical reintervention; more than 24 hours in invasive mechanical ventilation; patients who refused to sign the consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-2t5svsq	The effects of audiovisual stimulation associated with nutritional intervention in individuals with depression	Recruiting	Intervention	2021-12-07	<NULL>	<NULL>	5084	Evaluation of the effects of audiovisual stimulation associated with a nutritional intervention on clinical symptoms, neurodegenerative biomarkers and cerebral activity in individuals with depression: a controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-20	Universidade do Sul de Santa Catarina	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-2t5svsq	<NULL>	Present a medical diagnosis of depression; being in pharmacological treatment; age group between 18 and 60 years; female and male	Individuals who are under nutritional monitoring with a nutritionist; following a specific eating plan; individuals with diabetes mellitus (type I or II); epilepsy, people with hypersensitivity to light; immunosuppressive, oncological and infectious diseases; pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:53
RBR-87b6r5s	Lamivudine for Retinal Edema in Diabetic Patients	Recruitment completed	Intervention	2021-12-07	<NULL>	<NULL>	6481	Oral Lamivudine for Diabetic Macular Edema: a Randomized Clinical Trial	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2022-02-14	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-87b6r5s	<NULL>	18 years old and older without gender restriction; Type 1 or 2 diabetes; Diabetic macular edema with central involvement; Central retinal thickness equal to or greater than 325 µm measured by spectral-domain optical coherence tomography (SD-OCT); Best-corrected visual acuity less than 74 letters measured by the Early Treatment Diabetic Retinopathy Study (ETDRS) table.	High-risk proliferative diabetic retinopathy; Hemoglobin A1c (HbA1c) greater than 12; History of panphotocoagulation, macular laser, anti-VEGF injection, or intraocular corticosteroid implant within the past 6 months; Presence of retinal alteration that, at the assistant physician&apos;s discretion, will not improve visual acuity even with the resolution of macular edema (foveal atrophy, condensation of foveal hard exudates); Diagnosis of ocular alteration, in addition to diabetic macular edema, which may alter visual acuity throughout the study (neovascular glaucoma, retinal vein occlusion, or uveitis); Positive serology for human immunodeficiency virus (HIV) or hepatitis B virus (HBV); Liver failure, or less than 40 mL/min/1,73 m2 estimated Glomerular Filtration Rate; History of lactic acidosis; Proven or suspected pregnancy, breastfeeding	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-34tv3fz	Assessment of Locked Nose Improvement in patients who received a Nasal Implant	Data analysis completed	Observational	2021-12-06	<NULL>	<NULL>	5076	"Evaluation of the improvement rate of Nasal Obstruction by the NOSE Scale in patients
submitted to Poly(ε-caprolactone) Absorbable Nasal Implant (PCL)"	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-06-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-34tv3fz	<NULL>	Patients aged between 50 and 79 years; with insufficiency of the nasal lateral wall confirmed through the positive Modified Cottle maneuver; with severe or extreme nasal obstruction in the evaluation by the NOSE Scale (Nasal Obstruction Symptom Evaluation Scale) (score ≥ 55); impossibility or refusal to perform functional rhinoplasty; and lack of significant improvement after clinical treatment for at least four continuous months.	Smoking patients; with decompensated chronic rhinitis; with nasosinusal polyposis; with nasal granulomatous diseases; with any inflammatory or infectious diseases or conditions in the nasal or facial region; with a history of nasal implants or some type of nasal filling; with immunosuppressive disease; with healing disorders; with uncontrolled systemic diseases such as diabetes or heart disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-9mqyz6j	The effect of physical exercise on quality of life, mental health and continuity of chemotherapy sessions in individuals with cancer undergoing online intervention: a randomized clinical study	Recruiting	Intervention	2021-12-06	<NULL>	<NULL>	5077	Effectiveness of Physical Exercise on quality of life, mental health and continuity of chemotherapy cycles in individuals with Cancer undergoing intervention through telemedicine: a randomized clinical study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade Estadual Paulista (UNESP), Faculdade de Ciências e Tecnologia, Campus de Presidente Prudente	Instituto do Câncer Oeste Paulista- INCOP	https://ensaiosclinicos.gov.br/rg/RBR-9mqyz6j	<NULL>	"Be 18 years of age or older;
Have been diagnosed with cancer (solid tumors);
Starting chemotherapy treatment or having completed half of the treatment;
Have access to the internet;
Sign the free and clear term"	"Present some kind of mental confusion that prevents them from participating in assessments and/or activities;
Present the use of crutches, canes, walkers, wheelchairs or other similar utensils that make it impossible to carry out the exercise protocol;
Present diagnosis of hematologic cancer.
Being in the palliative phase of the disease."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-7wjw5z6	Study to compare Chemotherapy and Hormone therapy performed before surgery in Breast Cancer patients who have positive hormone receptors:  response evaluation to proposed treatments	Not yet recruiting	Intervention	2021-12-06	<NULL>	<NULL>	5078	Clinical and pathological response rates to Neoadjuvant Hormone Therapy and Chemotherapy in patients with Luminal subtype breast tumors: a randomized, open-label, non-inferiority trial	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2022-01-02	Instituto de Medicina Integral Prof. Fernando Figueira - IMIP	Instituto de Medicina Integral Prof. Fernando Figueira - IMIP	https://ensaiosclinicos.gov.br/rg/RBR-7wjw5z6	<NULL>	"Histological diagnosis of invasive breast carcinoma with Estrogen Receptor (ER) expression &gt; 50%, Ki 67 ≦ 35%, HER2 negative and Progesterone Receptor (PR) &gt; 20%;
• Tumor ≧ 2cm on ultrasound or Tumor &lt; 2cm with at least 1 axillary lymph node diagnosed with metastatic involvement – Metastatic involvement should be defined by cytology (USG guided FNA of the suspected lymph node) or histology (suspected lymph node core biopsy or biopsy of sentinel lymph node performed before neoadjuvant therapy)"	"Metastatic disease;
Inflammatory breast cancer;
Impossibility of surgical or drug treatment due to comorbidities such as decompensated heart failure or hematological and biochemical parameters within the patterns of patterns described:
Hemoglobin &lt; 7.0 g ∕ dL;
FA 1.5 times the reference value;
Neutrophil count &lt; 1500 U ∕mm3 ;
Platelet count &lt; 100,000 U ∕µL;
Serum creatinine &gt; 1.5 mg ∕ dL;
Score &gt; 2 on the ECOG Scale - Eastern Cooperative Oncology Group;
Contraindication to the use of at least one of the drugs proposed for the study;
Ongoing pregnancy."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-8z4ctxq	Effect of green tea gel and hyaluronic acid on healing after wisdom teeth extraction	Not yet recruiting	Intervention	2021-12-06	<NULL>	<NULL>	5079	Effect of green tea and hyaluronic acid gel on the healing of post-extraction sites of third molars a split-mouth randomized controlled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-8z4ctxq	<NULL>	Over 18 years of age; Have good oral hygiene (Plaque Index &lt; 20%); Presence the four third molars; Have indication for tooth extraction of all third molars	Patients with periodontal disease; Patients with systemic diseases or conditions or who use medications that alter bone metabolism (except diabetics); Decompensated diabetics (glycated hemoglobin above 8%); Pregnant or lactating women; Heavy smokers (above 10 cigarettes a day); Presence of periapical lesions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-4w7zqjf	Analysis of the immediate effects of the application of acupuncture on physical and muscle performance parameters in young active practitioners	Recruitment completed	Intervention	2021-12-06	<NULL>	<NULL>	5080	Analysis of the Acute Effects of the Application of Systemic Acupuncture on Physical and Muscular Performance Parameters in active young practitioners	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-01-28	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-4w7zqjf	<NULL>	Male athletes, professionals or amateurs will be included in the sample and are undergoing regular weekly training in their respective sports. The age range of these individuals must be between 16 and 40 years old.	The sample must be composed of healthy individuals on the day of the evaluations, so those who show signs such as more severe flu, respiratory tract infection, muscle and / or joint pain in general or any other type of pain in any part of the body will be excluded. body, have not suffered more serious muscle injuries or bone fractures in the last 06 months and have not been practicing any type of physical rehabilitation such as physiotherapy in the last days (due to some more recent physical impairment), have not been subjected to any process in the last 12 months surgical on any of the joints that can be used in the tests or any other surgery considered more delicate from a clinical point of view that requires greater care during and after rehabilitation for a longer time (such as cardiac or neural surgeries). Smokers with chronic diseases such as hypertension, diabetes, chronic kidney disease, coronary artery disease, autoimmune diseases, metabolic diseases under treatment such as cancer and AIDS and psychiatric diseases will also be excluded. The participation of female individuals will also be excluded due to changes in temperature due to hormonal variations, as well as during the menstrual cycle.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-96584w4	Effect of the Methylene Blue drug in patients with Severe Infection	Recruiting	Intervention	2021-12-06	<NULL>	<NULL>	5081	Effect of Methylene Blue on hemodynamic and metabolic response in Septic Shock patients	<NULL>	2, randomized-controlled, open	2	<NULL>	<NULL>	<NULL>	2018-04-01	Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Faculdade de Medicina de São José do Rio Preto	https://ensaiosclinicos.gov.br/rg/RBR-96584w4	<NULL>	Aged between 18 and 85 years; of both sexes; who were victims of septic shock of any origin in the first 72 hours of evolution; in use of noradrenaline larger dose 0.3 mcg/kg/min; vasopressin dose 0,05 ui/min; and using mechanical ventilation	Pregnant patients (negative pregnancy test in female patients of childbearing age); in use of serotonergic agents; previous septic shock in the same hospital; use of immunosuppressive therapy; CD4 smaller 200 cells/mm3; neutrophils smaller 500 mm3; palliative care; imminent or inevitable death during hospitalization	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-6btb6zz	Non-pharmacological therapies in the treatment of breast hardening	Recruiting	Intervention	2021-12-06	<NULL>	<NULL>	5082	Therapy by biophysical agents on breast engagement in infants	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	universidade federal do acre	universidade federal do rio de janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6btb6zz	<NULL>	Women in the lactation period, with the presence of unilateral or bilateral breast engorgement, primiparae or multiparae, coming from vaginal or cesarean delivery, hospitalized in the hospital or seeking guidance and/or care at the Human Milk Bank present at the aforementioned institution.	Women with a possible picture or finding of puerperal breast mastitis, women who have breast implants, presence of neoplastic process, women who did not sign the free and informed consent form and who were unable to sustain a minimum time of five minutes for the procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-2sm4qmy	Immunosenescence and COVID-19	Terminated	Observational	2021-12-06	<NULL>	<NULL>	6748	Impact of immunosenescence in the outcome of COVID-19	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-02-25	Universidade Federal de Minas Gerais (UFMG)	Merck Sharp & Dohme Farmacêutica Ltda	https://ensaiosclinicos.gov.br/rg/RBR-2sm4qmy	<NULL>	All indivíduals that are tested positive for SARS-Cov2 by PCR . Above 20 years of age. Negative individuals will be recruited as controls. Both genders	Individuals bellow 20 years of age	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:54
RBR-4bct2km	Evaluation of different protocols of local anesthesia, antibiotic therapy and laser therapy in wisdom tooth extraction surgeries	Recruitment completed	Intervention	2021-12-06	<NULL>	<NULL>	6808	Evaluation of different trans-operative protocols of local anesthesia and post-operative protocols of  antibiotic and lasertherapy in third molar extraction surgeries. A randomized controllled trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-4bct2km	<NULL>	Over 18 years of age; have good oral hygiene (Plaque Index &lt; 20%); Presence of the four third molars; Have indication for tooth extraction of all third molars	Patients with periodontal disease; patients with systemic diseases or conditions or who use medications that alter bone metabolism (except diabetics); decompensated diabetics (glycated hemoglobin above 8%); pregnant or lactating women; heavy smokers (over 10 cigarettes a day); presence of periapical lesions; presence of pericoronitis lesions; patients allergic to penicillins	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:56
RBR-3bs8xc6	Pilates and Dance classes for patients diagnosed with Head and Neck Cancer in treatment and post-treatment.	Recruiting	Intervention	2021-12-05	<NULL>	<NULL>	5075	Are dance therapy and the solo Pilates method effective in the physical and psychological aspects of patients undergoing treatment and post-treatment of head and neck cancer? A randomized clinical trial	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Fundação Universidade do Estado de Santa Catarina - UDESC	Centro de Pesquisas Oncológicas - CEPON	https://ensaiosclinicos.gov.br/rg/RBR-3bs8xc6	<NULL>	Age over 18 years old; Being in treatment or post-treatment for head and neck cancer; To be resident in the cities of Florianópolis or São José; Present a release from the oncologist responsible for the practice of physical activity or from the Physiotherapy Sector of CEPON; Present full vaccination certificate against Covid-19.	Present any orthopedic limitation, such as the use of a wheelchair, or neurological, cognitive, visual or auditory limitation that prevents the practice of physical activity within the proposed protocol, through a questionnaire; Have practiced dance therapy or solo Pilates for the past three months. Not being present in at least 75% of the prescribed meetings.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-8dvnsjh	Effects to the nervous system of Passive Technique on the Chest in patients with High Blood Pressure, immediate result and after 1 week	Recruitment completed	Intervention	2021-12-03	<NULL>	<NULL>	5071	Afferent Effects of Articulatory Technique for increased Mobility of the Rib Cage in Autonomic Function in Hypertensive Patients, acute and follow up after 1 week	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2020-05-26	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-8dvnsjh	<NULL>	Be male, enjoy good systemic health, clinical diagnosis of arterial hypertension and use of medication for this, ages between 40 and 70 years.	Being female, inability to sit in a sitting position, musculoskeletal disorders, hospitalization episodes in the last 3 months, indigenous ethnicity and quilombolas, pathology acquired during the research that causes hospitalization, absence on the day of assessment and data collection, ingestion of any substance that may influence the results.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-8jgpmjf	Impact of a Physical Exercise Program on Muscle, Lung, Quality of Life, Sleep, and Mental Health of Recovered Covid-19 Patients	Recruiting	Intervention	2021-12-03	<NULL>	<NULL>	5072	Impact of a Cardiovascular Rehabilitation program about Physical Capacity, Lung Function, Quality of Life, Sleep and Mental Health of patients in Covid-19 recovery	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-09	LETFAS- Laboratório de estudos do Treinamento Físico aplicado a Saúde	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8jgpmjf	<NULL>	both sexes; between 18 and 60 years old; clinically recovered from covid-19 for at least 20 days; not having used invasive mechanical ventilation; no physical or clinical restrictions that prevent the performance of the physical training program	Missing 3 consecutive days of training; Absence in at least one of the assessments; Present pain or worsening of the clinical condition with the intervention; missing more than 3 training sessions in general	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-9bb2fpn	Quality of life questionnaire related to symptoms of gastroesophageal reflux disease.	Recruiting	Intervention	2021-12-03	<NULL>	<NULL>	5073	Development and validation of a quality of life questionnaire related to symptoms of gastroesophageal reflux disease (QQV-GERD).	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Hemocentro de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-9bb2fpn	<NULL>	Adults aged between 18 and 65 years of both genders with preserved comprehension capacity, literate, must sign the informed consent form before data collection and have typical and/or atypical symptoms of gastroesophageal reflux disease with results of upper digestive endoscopy, esophageal manometry and prolonged pH monitoring.	Adults with diagnosed psychiatric illness, neurological disease, neoplasms, patients with cognitive impairment, illiterate patients and patients with severe visual impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-6nw2fdj	The Effect of Osteopathy in Patients with Fibromyalgia.	Not yet recruiting	Intervention	2021-12-03	<NULL>	<NULL>	5074	The Influence of Osteopathic Manipulative Treatment in Patients with Fibromyalgia Syndrome. A Randomized Controlled Clinical Trial.	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-07	Escola de Osteopatia de Madrid	Escola de Osteopatia de Madrid	https://ensaiosclinicos.gov.br/rg/RBR-6nw2fdj	<NULL>	The inclusion criteria adopted in the study will be: The individuals participating in the study will be (a) women with a medical diagnosis of fibromyalgia or (b) who respond positively to the ACR test, (c) age not less than 18 years and not more than 60 years, (d) with pain for more than 3 months, (e) not pregnant, (f) no history of other concomitant pathologies of rheumatologic origin (rheumatoid arthritis, lupus).	The exclusion criteria are (a) not signing the informed consent form.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-3g7q8bx	Effect of Abdominal Exercises on scapular positioning and shoulder performance in people with Shoulder Pain and Altered Scapulae	Recruiting	Intervention	2021-12-02	<NULL>	<NULL>	5065	Effect of different strategies Periescapular Muscles Resistance Training  associated with Core Training on pain, function and performance of subjects with Shoulder Impact Syndrome and Scapular Dyskinesis	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade de Pernambuco	UNIVERSIDADE DE PERNAMBUCO	https://ensaiosclinicos.gov.br/rg/RBR-3g7q8bx	<NULL>	Both sexes; have a medical or physiotherapeutic diagnosis of subacromial pain; positivity in specific orthopedic tests (Neer, Hawkins-Kennedy, Jobe and painful arch); be physically independent.	Present clinical conditions or unstable disease that contraindicates the practice of supervised physical exercise; present range of motion of arm flexion less than 120°; have a history of trauma or surgery on the shoulder; have severe deformities in the thoracic spine (scoliosis or hyperkyphosis); be positive for clinical tests of glenohumeral instability.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-4xjvsqh	Assessment of quality of life pain and mouth opening after wisdom tooth extraction using different oral dexamethasone protocols	Recruitment completed	Intervention	2021-12-02	<NULL>	<NULL>	5066	Evaluation of quality of life pain and trismus after lower third molar extraction using different oral dexamethasone protocols	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-04-30	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4xjvsqh	<NULL>	Patients between 16 and 39 years old;  ASA I, according to the criteria of the American Society of Anesthesiology (ASA); requiring bilateral extraction of lower third molars; dental elements that present similar positioning; impacted teeth Classes 1 and 2; A and B by Pell and Gregory; non-smokers.	history of pericoronitis in the lower third molar region; allergy to any of the medications used.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-643zqt5	Analysis of physical activity and educational program on the burden and quality of life of caregivers of people with Amyotrophic Lateral Sclerosis.	Not yet recruiting	Intervention	2021-12-02	<NULL>	<NULL>	5067	Effects of a physical activity program through a teleservice with an educational program on overload, depression, stress and quality of life of caregivers of people with Amyotrophic Lateral Sclerosis: Randomized Controlled Clinical Trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Federal do Rio Grande do Norte	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-643zqt5	<NULL>	Be an informal caregiver of a person diagnosed with ALS, be over 18 years old. Not having cognitive impairment to understand the course and the term of clarification. Being a caregiver of people with ALS, without other neurological disorders, has to be literate, with complete elementary education.	If they present any pathology that prevents them from performing physical activity. Caregivers in the first trimester of pregnancy. Or, are taking psychiatric medication.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-8vrj4xg	Measurement of breathing by skin electrodes using electrical impedance tomography	Recruitment completed	Observational	2021-12-02	<NULL>	<NULL>	5068	Non-invasive tidal volume estimation by electrical impedance	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2019-07-15	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-8vrj4xg	<NULL>	Age above six years; Either gender	Individuals with cardiac pacemaker or other implanted electronic device; Individuals with skin lesions in the thoracic area where the electrical impedance tomography belt will be placed; Individuals with impaired functional capacity (NYHA level IV), which would suffer with fatigue and discomfort during the tests; Pregnancy; Individuals who refused the participation on the study by the means of the non-signature on the consent form (and its equivalent with individuals under the age of 18 years and their parents)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-4nq8cbp	Analysis of the benefits of Electrical Stimulation on the memory of healthy elderly people	Not yet recruiting	Intervention	2021-12-02	<NULL>	<NULL>	5069	Transcranial Direct Current Stimulation on cognitive performance of healthy older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4nq8cbp	<NULL>	Sedentary elderly, of both sexes, aged between 60 and 90 years old, living in the municipality of Campo Grande / MS and who do not have neurological or psychiatric disorders	Elderly people with cognitive decline (associated or not with dementia), heart disease participants, subjects with difficulties in understanding the tests. Participants who have more than four consecutive absences in therapies and a recent crisis of labyrinthine dysfunction will also be excluded from the research.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-5msn9mw	Bright light influence on blood vessel response to hand exercise	Recruitment completed	Intervention	2021-12-02	<NULL>	<NULL>	5070	Bright light influence on vasodilation induced by dynamic handgrip exercise	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Escola de Educação Física e Esporte da Universidade de São Paulo	Escola de Educação Física e Esporte da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5msn9mw	<NULL>	Men; Aging between 20 and 39 years old	Body mass index higher than 30kg/m²; Blood pressure levels above139/89 mmHg; Presence of cardiovascular disease; Smoking; Be physicaly active; Use of regular medications; Take supplements; Presence of an extreme chronotypes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-106mfmx6	Use of soft-tissue substitutes in the treatment of exposed rooth tooth	Recruitment completed	Intervention	2021-12-02	<NULL>	<NULL>	6762	Use of xenogenic soft-tissue substitutes in the treatment of gingival recessions: A controlled randomized trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Universidade Federal de Uberlândia	Universidade Federal de Uberlândia	https://ensaiosclinicos.gov.br/rg/RBR-106mfmx6	<NULL>	Present a single or multiple gingival recessions classified as RT1 (Miller class I and II) that require surgical treatment; Lack of previous experience with surgical treatment to treat gingival recessions; Ability to maintain good oral hygiene; Presence of non-carious cervical lesions associated with at least one of the gingival recessions; Being systemically healthy or having compensated systemic diseases; Present age between 18-60 years old.	History of untreated periodontal disease; Cigarette consumption greater than 10 units per day; Furcation lesion on the tooth to be treated; Presence of severe crowding, rotation or poor positioning of the tooth to be treated; Hypersensitivity to any anesthetic, medication or antiseptic product used in surgery; Medical limitation for elective surgical procedures; Pregnant or lactating women.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:55
RBR-6q3w5k7	Air-volume measurement during newborns respiration while breathing calmly using electrical impedance tomography	Recruiting	Observational	2021-12-01	<NULL>	<NULL>	5064	Evaluation of tidal volume in spontaneous ventilation by electric impedance tomography in eupneic newborns	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-08-01	Faculdade de Medicina de Ribeirão Preto - Universidade de São Paulo	Timpel S.A	https://ensaiosclinicos.gov.br/rg/RBR-6q3w5k7	<NULL>	Newborns with 32 weeks of corrected gestational age at the moment of the data acquisition; without the need of ventilatory support; the ones considered eupneic at the moment of the data acquisition	Newborns with cardiac pacemaker or other electronic implantable device; newborns with skin lesions in the area where the electrical impedance tomography belt will be placed; newborns with genetic syndromes or important cardiac malformations; newborns who could not be calmed and became too agitated during the assessments; newborns who had been previously mechanically ventilated or with history of pulmonary compromise	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-9hfr3kf	Individualized Sports Mouthguards: Evaluation of Muscle Effects and Sports Performance in Children	Not yet recruiting	Intervention	2021-11-30	<NULL>	<NULL>	5063	Individualized Sports Mouthguards: Evaluation of Muscle Effects and Sports Performance in Children	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-02	Faculdade de Odontologia de Ribeirão Preto	Faculdade de Odontologia de Ribeirão Preto	https://ensaiosclinicos.gov.br/rg/RBR-9hfr3kf	<NULL>	Participants must present a normal nutritional status; mixed and/or permanent dentition, with the presence of the first four permanent molars; normal occlusion; absence of temporomandibular disorder; absence of other pathologies that could compromise the musculature of the stomatognathic system; and belong to the pre-established age group.	Individuals who present decompensated neurological and systemic pathologies, periodontal disease, cavitated caries lesions, parafunctional habits, under treatment with anti-inflammatory drugs and who are under orthodontic, speech therapy or otorhinolaryngological treatment will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-10fghxtm	Effects of exercise and antioxidant supplementation in individuals with diabetes kidney disease	Withdrawn	Intervention	2021-11-30	<NULL>	<NULL>	5148	Controlled and randomised clinical study on the effects of exercise associated with antioxidant supplementation on redox and immuno-metabolic regulation in patients with diabetes renal disease	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-03-01	Pontifícia Universidade Católica do Paraná	Pontifícia Universidade Católica do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-10fghxtm	<NULL>	Female and male; ages 40 to 65; staging of chronic kidney disease 3 and 4 degree; body mass index: lower than obesity grade 2; glomerular filtration rate estimated by the equation developed by Chronic Renal Disease Epidemiology Collaboration (CKDEPI) and according to stage 3 and 4; presence of optimized drug therapy and without the prediction of change in drug doses of renin-angiotensin aldosterone system blockers, mineralocorticoid antagonist or sodium cotransporter inhibitors and glucose with stable doses up to 4 weeks prior to randomization and during the 7 months of intervention.	Heart failure; severe coronary heart disease indicating physical activity or cardiovascular surgery (e.g. coronary bypass, valvar exchange or angioplasty) within the last 6 months; uncontrolled cardiovascular disease; percentage of glycated haemoglobin greater than 9; chronic lung disease; active viral infections; neurological and mental disorders, musculoskeletal impairment that prevents physical exercise, malignancy (except epidermoid carcinoma) or debilitating and warfarin users.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:55
RBR-83mprnv	Assessment of left ventricular function using imaging exam	Not yet recruiting	Observational	2021-11-29	<NULL>	<NULL>	5060	Assessment of left ventricular function using Myocardial Strain in cardiac surgery	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-12-15	Universidade do Extremo Sul Catarinense	Universidade do Extremo Sul Catarinense	https://ensaiosclinicos.gov.br/rg/RBR-83mprnv	<NULL>	Patients undergoing cardiac surgery with extracorporeal circulation (ECC) and left ventricular ejection fraction (LVEF) ≥ 50% who will undergo echocardiographic monitoring with myocardial strain.	Patients undergoing cardiac surgery without CPB, patients with LVEF &lt; 50%, urgent and emergency surgery, patients with grade II or III diastolic dysfunction, use of intra-aortic balloon pump in the preoperative period and refusal to participate in the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-4w3nq4k	Osteopathy in the treatment of reflux	Recruitment completed	Intervention	2021-11-29	<NULL>	<NULL>	5061	Effects of using osteopathic manipulative techniques applied to patients with gastroesophageal reflux disease (GERD)	<NULL>	1-2, randomized-controlled, open	1-2	<NULL>	<NULL>	<NULL>	2021-06-05	Larisse Dunke Pereira	Larisse Dunke Pereira	https://ensaiosclinicos.gov.br/rg/RBR-4w3nq4k	<NULL>	Present medical diagnosis of Gastroesophageal Reflux Disease; both genders; age between 25 and 55 years; Body mass index less than or equal to 30; agreeing to participate in the study by signing the Informed Consent Form and being available to participate in the study within the proposed schedule.	Pregnancy; spine surgery; abdomen or chest surgery; plastic surgery of the head and trunk, fractures in the vertebrae or ribs; cervical trauma; patient receiving chemotherapy or radiotherapy; have been diagnosed with inflammatory joint disease; disorders of the metabolic system; rheumatic disease; neurological impairment; acute inflammatory process; use of medications that interfered with the pain threshold; injury that prevents him from effectively developing the proposed protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-3fwtryt	Ocurrence of temporomandibular disorder symptoms with the use of orthodontic aligners	Recruiting	Intervention	2021-11-29	<NULL>	<NULL>	5062	Incidence of temporomandibular disorder symptoms with the use of orthodontic aligners	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-27	Ana Luiza Corrêa da Silva	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-3fwtryt	<NULL>	patient who agreed to sign the consent form; patients with no symptoms of TMD( temporomandibular dysfunction) or orofacial pain	current use of muscle relaxants or any medication that affects masticatory muscle activity; presence of any systemic disorder affecting motor behavior and pain perception;daily use of any analgesic;orthodontic treatment that requires extractions;and neurological or psychiatric problems	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-8xzkyp2	Effect of cashew nut and its oil on weight loss, blood pressure, sugar and fat in the blood, and bowel improvement in individuals at excess of weight	Recruitment completed	Intervention	2021-11-25	<NULL>	<NULL>	6492	Effect of the cashew nut and its oil on cardiometabolic, genetic and intestinal microbiota risk markers in  individuals at excess of weight	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-03	Universidade Federal de Viçosa	Embrapa Agroindústria Tropical	https://ensaiosclinicos.gov.br/rg/RBR-8xzkyp2	<NULL>	Men and women between 20 and 55 years old; Excess weight (≥ 27 kg/m²), high waist circumference (≥ 80 cm for women; ≥ 90 cm for men) and excess body fat (&gt; 30% for women and &gt; 20% for men) associated with another component of the Metabolic Syndrome: triglycerides ≥150 mg/dL; blood pressure ≥ 130/85 mmHg) or fasting glucose ≥100 mg/dL or; Obesity (BMI ≥ 30 kg/m²) regardless of the presence of other components of the Metabolic Syndrome.	Pregnant, lactating or menopausal women; Athletes; Smokers; Vegans; Shift workers; With a history of HIV, digestive, hepatic, renal, cardiovascular, thyroid, cancer, inflammatory diseases or eating disorders; Who have a history of drug and/or alcohol abuse; Aversion or allergy to nuts; Who has had an infection in the last month; Consume more than 30 g/day of nuts; Make use of certain medications such as anti-inflammatory drugs, corticoids and antibiotics; Have problems that can interfere with chewing; Weight instability (5% of usual weight) in the last 3 months; Alcohol consumption &gt; 21 units (≈168g) per week; Consumption of vitamin, mineral and omega 3 supplements.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:45
RBR-3h484dp	Injections for back pain	Recruiting	Intervention	2021-11-24	<NULL>	<NULL>	5059	Orthobiologics therapy for back pain	<NULL>	2-3, randomized-controlled, double-blind	2-3	<NULL>	<NULL>	<NULL>	2018-01-01	Dr. Edilson Silva Machado	Grupo Hospitalar Conceição	https://ensaiosclinicos.gov.br/rg/RBR-3h484dp	<NULL>	Low back pain for more 12 weeks. Failure of conservative treatments (oral medications; physical therapy). Satisfy criteria for lumbar epidural; facet; intradiscal or paravertebral intramuscular injection.	Refusal to participate in research. Age younger than 18 year old or older than 80 year old. Active infection. Neoplasm. Conditions requiring surgery: cauda equina syndrome; spinal instability; progressive neurological deficit. Severe stenosis. Allergy to contrast material or local anesthesia. Presence of unstable psychiatric condition. Hematologic disorders: thrombocytopenia; coagulation disorders; sickle cell disease.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-5mnf4zp	Analyzing a desensitizing protocol for visible tooth whitening: a clinical, blind, randomized study	Recruitment completed	Intervention	2021-11-23	<NULL>	<NULL>	5056	Analysis of a desensitizing protocol for external tooth whitening: a randomized, blinded clinical study	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-13	Universidade Estadual do Oeste do Paraná	Universidade Estadual do Oeste do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-5mnf4zp	<NULL>	Good general and oral health; 18 to 50 years old; have at least six upper anterior teeth free of caries, restorations or endodontic treatment; canines shade A2 or darker as assessed by the VITA shade scale (VITA Classical Shade, VITA Zahnfabrik, Bad Säckingen, Germany).	Orthodontic appliances; dental prosthetics; severe internal tooth discoloration; pulped teeth; pregnant and nursing women; patients with bruxism or any pathology that may cause sensitivity; recession; dentin exposure; visible cracks; patients who use anti-inflammatory drugs or analgesics; patients who underwent tooth whitening.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-5mgrttm	Study of the change in heart rate in people with high blood pressure	Recruitment completed	Intervention	2021-11-23	<NULL>	<NULL>	5057	Heart rate variability in Hypertensive patients	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2012-10-26	Faculdade Medicina ABC	Faculdade Medicina ABC	https://ensaiosclinicos.gov.br/rg/RBR-5mgrttm	<NULL>	Clinical and laboratory diagnosis of controlled systemic arterial hypertension, being a practitioner of some regular physical activity, and being between 65 and 80 years of age.	Changes, such as heart disease, pulmonary malformations; changes in the central nervous system and / or neurological syndrome; use of drugs that may interfere with the study participants&apos; autonomic responses; patients with a history of cardiovascular disease; patients with any medical condition that makes it impossible to adhere to the protocol or safely execute	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-9tk9pwz	Study comparing the efficacy of fosfomycin and ciprofloxacin antibiotics in the antibiotic prophylaxis of transrectal prostate biopsy	Data analysis completed	Intervention	2021-11-23	<NULL>	<NULL>	5058	Comparative study between fosfomycin and ciprofloxacin in transrectal prostate biopsy prophylaxis	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-04-08	Universidade Federal do Paraná - Campus Toledo	Universidade Federal do Paraná - Campus Toledo	https://ensaiosclinicos.gov.br/rg/RBR-9tk9pwz	<NULL>	male gender; have a formal indication for prostate biopsy; aged between 18 and 100 years.	patients who for some reason cannot take the proposed medications; patients with a history of severe bleeding complications during the biopsy procedure.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-6qbx4h6	Study of formulations containing extract of Acmella oleracea (L.) R.K. Jansen (Asteraceae) (Jambu) in patients with decreased sexual potency or rapid ejaculation	Not yet recruiting	Intervention	2021-11-22	<NULL>	<NULL>	5055	Study of the clinical efficacy and safety of pharmaceutical formulations containing Acmella oleracea (L.) R.K. Jansen (Asteraceae) extract in patients with erectile dysfunction or premature ejaculation	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal do Amapá	Universidade Federal do Amapá	https://ensaiosclinicos.gov.br/rg/RBR-6qbx4h6	<NULL>	male, erectile dysfunction, stable affective relationship, fixed single partner, patients with premature ejaculation	anatomical genital deformities; erectile dysfunction secondary to spinal cord injury, concomitant diagnosis of other sexual dysfunctions , prolactin level greater than three times the upper limit, testosterone level less than 300, uncontrolled psychiatric disorder, decompensated diabetes mellitus, history of stroke, myocardial infarction, significant cardiovascular disease, poorly controlled arterial hypertension, history of important hematological, renal, hepatic abnormalities, abuse of illicit substances	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-2tz9dky	Safety and tolerability study to evaluate of Pentosan Polysulfate Sodium in treating subjects with Mucopolysaccharidosis type VI	Data analysis completed	Intervention	2021-11-22	<NULL>	<NULL>	5267	A phase 2, randomized, double blind, placebo-controlled study to evaluate the safety and tolerability of Pentosan Polysulfate Sodium in treating subjects with Mucopolysaccharidosis (MPS) type VI (Maroteaux-Lamy Syndrome)	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2021-06-22	Hospital de Clínicas de Porto Alegre da Universidade Federal do Rio Grande do Sul	Hospital de Clinicas de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-2tz9dky	<NULL>	Male and female subjects greater than or equal to 5 years of age; confirmed diagnosis by genetic testing and/or enzyme activity of  Mucopolysaccharidosis (MPS) Type VI (N-acetylgalactosamine-4-sulfatase deficiency and a second normal sulfatase enzyme); must be on enzyme replacement therapy (ERT) for greater than or equal to 1 year; must be on at stable dose of enzyme replacement therapy (ERT) for 3 months prior to baseline; must have a mean pain score of a minimum of 3 and a maximum of 9 on the Faces Pain Scale-Revised (FPS-R) taken from the first 5 consecutive measurements at screening; able to walk 30 metres with or without use of an assistive device; 6MWT less than or equal to 70% (percent) predicted of normative mean value for age; participant demonstrates an impairment of ROM in at least one shoulder; participant or parent, or legally acceptable representative sufficiently able to understand the purposes and risks of the study and able to provide written informed consent or in the case of participants age less then 18 years, provide written assent (if required) and written informed consent by a legally authorized representative after the nature of the study has been explained, and prior to any research-related procedures or study assessment; if applicable, participants must be willing to comply with the medically acceptable contraceptive requirements of the study from screening to at least 28 days after the last investigational product (IP) administration; participants should not be pregnant or breastfeeding at the time of study entry; participants must be willing and able to comply with all scheduled visits, treatment plan, laboratory tests, and other study procedures	Documented or reported history of increased bleeding tendency in the presence or absence of anticoagulant or antiplatelet drugs; history of heparin induced thrombocytopenia; current treatment with anticoagulants or antiplatelet drugs, excluding aspirin less than or equal to 100 mg per day; absence of limitation in upper extremity fine motor skills; absence of shoulder joint Range of Motion (ROM) limitations; participant taking opioids within 2 weeks of Day 1 or unwilling to stop the treatment opioids throughout the study; parenteral iloprost from 12 weeks before Day 1 and throughout the study; parenteral bisphosphonates from 12 months before Day 1 and throughout the study; currently active or recent history (within preceding 12 months) of a gastric or duodenal ulcer, or suspicion of gastrointestinal (GI) tract bleeding; coagulation parameters or platelets outside laboratory reference range, liver function tests greater than or equal to 1.5 × upper limit of normal (ULN), or estimated glomerular filtration rate (eGFR) less then 30 mL per min at Screening; hepatic synthetic insufficiency (including Gilbert’s Syndrome); history of bone marrow transplant or haematopoietic stem cell transplant; history or evidence of chondrocalcinosis or fibromyalgia; history or evidence of HIV, hepatitis B or hepatitis C; major surgery within 12 weeks preceding Day 1 or anticipated surgery in the study period; medical history or evidence of any clinically significant active or chronic condition involving the musculoskeletal system, which in the opinion of the Investigator may impact assessment of safety or efficacy parameters or the validity of study results; current or recent immunosuppressive or immunomodulatory systemic therapy; currently hospitalised; any acute illness within 2 weeks of baseline; a history of drug or alcohol abuse and/or dependence as documented by participant/caregiver reporting within the 12 months preceding screening; participation in another clinical trial or administration of any investigational product or experimental product within 12 weeks or five half-lives (whichever is longer) preceding Day 1; history of significant hypersensitivity to pentosan polysulfate sodium (PPS) or drugs of a similar chemical or pharmacological class; any clinically significant abnormalities as judged by the Investigator at screening; history of or current clinically significant gastrointestinal (GI), hepatic, renal, cardiovascular, respiratory, endocrine, oncological, immunological, neurological, ophthalmological (including existing pigmentary maculopathy), haematological or psychiatric disorder or any other condition (with the exception of signs and symptoms relating to MPS VI), which in the opinion of the Investigator or Sponsor would jeopardize the safety of the subject or the validity of the study results; an employee of the Sponsor or research site personnel directly affiliated with this study or their immediate family members defined as a spouse, parent, sibling, or child, whether biological or legally adopted	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:23:01
RBR-8kqgnst	Effects of Dry Needle on Points of Muscle Tension in Subjects with Chronic Ankle Instability	Recruiting	Intervention	2021-11-19	<NULL>	<NULL>	5052	Effects of Dry Needling on Myofascial Trigger Points on the Sensory-Motor System of Subjects with Chronic Ankle Instability	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-19	Universidade Federal da Paraíba	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8kqgnst	<NULL>	be between 18 and 35 years old; present a history of a unilateral ankle sprain for at least 12 months;  report at least 2 episodes of instability sensation in the same ankle in the last 6 months; not having joint movement blockage due to surgical fixation, ankylosis or ankle arthrofibrosis;  not having undergone surgery in the lower limbs in the last 6 months;  not being in physiotherapeutic treatment for ICT; having a sensation of instability in the ankle (&lt; 25 points in CAIT); not having systemic disease, vascular disease in the lower limbs and pain syndromes; no symptoms of peripheral nerve damage;  do not use non-steroidal anti-inflammatory drugs or any medication that alters the perception of pain.	not completing the proposed intervention; absence in at least one of the evaluations;  present pain or worsening of the clinical condition with the intervention.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-3dcb3jy	Evaluation of the quality of life of coffee producers in Poço Fundo-MG with the SF-36 instrument during the covid-19 pandemic	Recruitment completed	Intervention	2021-11-19	<NULL>	<NULL>	5053	Evaluation of the quality of life of coffee growers in Poço Fundo-MG with the SF-36 instrument during the covid-19 pandemic	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-01-04	UNISEPE - Uniao Das Instituicoes De Servico Ensino e Pesquisa	UNISEPE - Uniao Das Instituicoes De Servico Ensino e Pesquisa	https://ensaiosclinicos.gov.br/rg/RBR-3dcb3jy	<NULL>	Coffee growers participating in the WhatsApp group of the company COOPFAM; over 18 years; both sexes and who agree to participate in the survey by asking about their consent.	Individuals who are not coffee growers; individuals who do not understand the reading and interpretation of the questionnaire.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:52
RBR-106tgthm	Training and supplementation in the performance of high-performance athletes	Suspended	Intervention	2021-11-17	<NULL>	<NULL>	5051	High Intensity Training (HIIT) applied to high athletes income with and without leucine supplementation: implications for performance	<NULL>	1, randomized-controlled, double-blind	1	<NULL>	<NULL>	<NULL>	2020-07-06	FAMED/UFU - Faculdade de Medicina da Universidade Federal de Uberlândia	PPCSA - Programa de Pós-Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-106tgthm	<NULL>	Eligibility criteria: Group 1 (soccer players). Be willing to participate voluntarily and sign the Informed Consent Form; Age between 15 and 17 years old; Play soccer; Male; Absence of diagnosed heart disease; Absence of thyroid dysfunction; Being active and without complications that prevent the achievement of physical expectations and the proposed training; You are not using medication or supplementation in the last 30 days that precede the protocol for the proposed study; Comply with the stipulated frequency of 85%; Finalization of all assessment protocols. Group 2 (street runners). Be willing to participate voluntarily and sign the Informed Consent Form; Age between 18 and 39 years old; Amateur elite street runner; male and female; Absence of diagnosed heart disease; Absence of thyroid dysfunction; Time and personal marks of up to 20 minutes for men and 25 minutes for women in the distance of 5 km from running to the event; Being active and without complications that prevent the achievement of physical expectations and the proposed training; You are not using medication or supplementation in the last 30 days prior to the protocol proposed by the study; Comply with the stipulated frequency of 85%; Completion of all assessment protocols	Exclusion criteria: detection of factors associated with heart disease diagnosed in the anamnesis performed by health professionals or in clinical laboratory tests; presence of dysfunction thyroid; appearance of injuries that make training impossible	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-3tpvp8t	Lasers and B complex use in patients with taste disorders caused by COVID-19	Recruiting	Intervention	2021-11-17	<NULL>	<NULL>	5589	Photobiomodulation and B complex use in patients with taste disorders caused by COVID-19. In vivo, randomized and double-blind study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-3tpvp8t	<NULL>	Volunteers of both sexes; 18 years old or more; Positive PCR for COVID19; ageusia; dysgeusia; parageusia; symptoms lasting minimum of 2 months.	Less than 18 years old; Pregnant; Lactating; PCR with less than 2 months; absence PCR test attesting COVID19 infection.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:12
RBR-6xcf92d	Use of postural insole, associated with strengthening the hip muscles, in the treatment of the knee of amateur athletes	Recruiting	Intervention	2021-11-16	<NULL>	<NULL>	5049	Use of postural insole, associated with strengthening the hip muscles, in the treatment of dynamic knee valgus dysfunction in amateur athletes: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-05	UFPB - UNIVERSIDADE FEDERAL DA PARAÍBA	UFPB - UNIVERSIDADE FEDERAL DA PARAÍBA	https://ensaiosclinicos.gov.br/rg/RBR-6xcf92d	<NULL>	Volunteers with age between 12 and 50 years; Active practitioners of sports activities, of an amateur nature, of court sports, which involve jumping or turning in an axial axis on the lower limbs, such as: football, volleyball, basketball, handball and tennis; Have dynamic valgus of at least one of the knees, whether this is dominant or not; Have excessive pronation of at least one of the knees, whether this is dominant or not; Do not have lower limb injuries that prevent them from carrying out the proposed assessments or interventions; Are not undergoing drug or physiotherapeutic treatment for any mechanical dysfunction.	Volunteers who drop out of the study or miss any of the assessments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-2fr526n	Effects of cell therapy with mesenchymal stem cells and platelet-rich plasma in the treatment of knee osteoarthritis	Data analysis completed	Intervention	2021-11-16	<NULL>	<NULL>	5050	Effects of cell therapy with mesenchymal stem cells from adipose tissue and platelet-rich plasma in the treatment of osteoartrite that was not responsive to drug treatment	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-06-29	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-2fr526n	<NULL>	Volunteer individuals were included; diagnosed through physical assessment; be classified by imaging with osteoarthritis grade II to IV; who already had an indication for knee surgery; patients unresponsive to conservative treatment (physical and drug) commonly used in the Unified Health System (SUS) for at least 6 months.	Individuals with extreme deformities of the knee joint were excluded; who reported having hemophilia, anemia, gastrointestinal diseases, cancer, thyroid, liver, and previous nephrological disorders and HIV; patients who were chronically using immunosuppressive and anticoagulant drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-4d9dmqz	Influence of polymorphisms on the sod3, pparα genes on physical performance and redox balacing of runners supplemented with a single dose of grape juice	Data analysis completed	Intervention	2021-11-12	<NULL>	<NULL>	5036	Influence of polymorphisms on the sod3, pparα and actn3 genes on oxidative stress, dna methilation and performance in corridors supplemented with red grape juice	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-02	Ufpb - Universidade Federal da Paraiba	Ufpb - Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-4d9dmqz	<NULL>	Inclusion criteria were defined as: athletes should have been training for at least one year with a frequency of at least four weekly sessions and for at least two months without interruption and taking part in competitions regularly. They also should not have any chronic condition or degenerative diseases, did not smoke, and were not using any long-term medication.	Participants should not consume purple grapes or their derivatives often; and/or dietary supplements, vitamins or bioactive substances present in the grape (polyphenols). Athletes who suffered from skeletal muscle injuries, altered dietary habits or had inconsistent training patterns, started using medication or did not perform some of the study experimental procedures were also excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-45jthpn	The effects of Virtual Reality on Physical therapy in patients admitted to intensive care units	Recruitment completed	Intervention	2021-11-12	<NULL>	<NULL>	5037	The effects of using Virtual Reality as an adjunct to the Early Mobilization of critical patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-45jthpn	<NULL>	Patients who are hospitalized in the adult ICUs of the HU-UEPG, over 18 years of age and who have not yet been in a sitting position in bed during hospitalization at the unit, will be included in the research. All study participants must accept and sign the free and informed consent form (FICF) and if they are not able, this knowledge must be given by the responsible family member.	Restless patients, with visual deficits, hemodynamically unstable, with pressure ulcers in the sacral region above grade II classified by the NPUAP/EPUAP system, or who for any reason do not adapt to virtual reality glasses will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-44y22nj	Treatment of obstructive sleep apnea in the elderly with intraoral appliance	Recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5038	Treatment of obstructive sleep apnea in the elderly with low-cost intraoral appliance: a multicentric study	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2020-01-06	FAPERGS - Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul	UFRGS - Universidade Federal do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-44y22nj	<NULL>	Healthy volunteers; both genders; aged 65 years or older.	Volunteer with less than 8 teeth in the lower jaw; dental implants installed less than 6 months ago; mouth breathers; mouth opening less than 30mm; temporomandibular joint pain or dysfunction; facial anomalies or neoplasms; absence of sleep apnea or severe apnea (score 30 or more); diagnoses of cardiac, hepatic, pulmonary, neurological or psychiatric pathologies.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-32g9wck	Comparing the treatment of Vulvar Condyloma, using two techniques: Laser and Electric.	Recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5039	Vulvar Acuminate Condyloma treatment: comparing surgical techniques using Diodo laser and Electrocaterization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2020-10-01	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-32g9wck	<NULL>	Volunteers; female. Attended in the gynecology outpatient with a clinical diagnosis (physical exam) of vulvar condyloma acuminata.	Volunteers suspected of having high-grade vulvar intraepithial lesion after physical exam. Volunteers suspected of vulvar cancer after physical exam. Volunteers diagnosed with Buschke-Löeenstein tumor. Volunteers with contraindication to locoregional or general anesthesia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-62fctqz	Preventive intervention in changes in body image, Eating Disorders and Muscle Dysmorphia in young adult Men of Sexual Minority	Recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5040	Preventive intervention in body image disturbances, Eating Disorders and Muscle Dysmorphia of Brazilian young adults: a randomized controlled trial in Male Sexual Minorities	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Universidade Federal de Juiz de Fora	Universidade Federal de Viçosa	https://ensaiosclinicos.gov.br/rg/RBR-62fctqz	<NULL>	Young adults men aged between 18 and 30 years. Men of any color, race or ethnicity. Agree to voluntary participation in the study.	Participants who do not identify themselves as sexual minority men (i.e., homosexual or bisexual). Ask for the termination of your participation, through an express, free and informed manifestation. Expressly request not to use your data. Have a mental disorder, eating disorder and/or body dysmorphic disorder diagnosed (self-reported).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-39yrht6	Influence of muscle strength on the ability to walk earlier in critically ill patients	Recruitment completed	Intervention	2021-11-12	<NULL>	<NULL>	5041	Influence of peripheral muscle strength on early ambulation of critically ill patients	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2018-01-31	Faculdade Nobre	Instituto Nobre de Cardiologia	https://ensaiosclinicos.gov.br/rg/RBR-39yrht6	<NULL>	As an exclusion criterion; Individuals of both genders with Coronary Artery Disease (CAD), aged over 60 years and submitted to myocardial revascularization procedure with cardiopulmonary bypass and median sternotomy.	Exclusion criteria; patients with intra-aortic balloon, surgical reintervention, death, valvopaths, previous pneumopathy, who did not understand the way of performing the proposed techniques, presented hemodynamic instability during the evaluation or application of the cycle ergometer and physical limitation, such as amputation, which compromised the performance of the exercises.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-9wp48fj	Measurement of alcohol concentration with a breathalyzer in healthy individuals after optimized food consumption.	Recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5042	Determination of alcoholemia after consumption of optimized food in a randomized controlled crossover clinical trial in healthy individuals	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-13	Ambev SA	Ambev SA	https://ensaiosclinicos.gov.br/rg/RBR-9wp48fj	<NULL>	"• Understand the study procedures and voluntarily agree to participate in the study and sign the Informed Consent Form (FICF – Appendix 1); 
• Men or non-pregnant women, non-lactating women, 25 to 55 years of age; body mass 20 - 30 kg / m2;
• Blood pressure: systolic &lt;140 and diastolic &lt;95 mmHg;
• Social (moderate) drinkers who drink an average of 2 or less drinks a day and have had no episodes of “excessive alcohol consumption ” in the previous 30 days. Excessive alcohol consumption is defined as drinking 4 or more drinks (for women) / 5 or more drinks (for men) over 2 hours. A drink is defined as approximately 150 ml of wine, 341 ml of beer / cider or 45 ml of distilled 40% alcoholic strength; 
• Willing to maintain a habitual diet, physical activity pattern and body weight throughout the test and consume standard meal provided by the research team on the evening before each test day; 
• Willing to refrain from strenuous exercise, alcoholic beverages, and marijuana use 24 hours prior to study visits; 
• Willing to refrain from driving or operating any vehicle when leaving the research laboratory after the testing visit; 
• Willing to sign on each test day a statement acknowledging that the subject is aware that they consumed alcohol that morning (Appendix 2); 
• Willing to maintain current dietary supplement use throughout the study. On test days, the subject agrees not to take any dietary supplements or caffeine. Failure to comply will result in a rescheduled test visit; 
• No serious illness or surgery that requires hospitalization within 3 months of the first study visit following screening; 
• No history of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or liver disease; 
• Absence of health conditions that prevent them from meeting the study requirements as judged by the investigator based on medical history; 
• Women are willing to use a contraceptive method to prevent pregnancy during the study period, and willing to have a test of urine pregnancy on the day of each study."	"• Failure to meet all inclusion criteria;
• Smoker;
• History of gastrointestinal, hepatic, renal, or cardiovascular disease (including, but not limited to, atherosclerotic disease, history of myocardial infarction, peripheral arterial disease, stroke) and lung disease;
• History of mental illness, seizures, use or abuse of psychoactive medications (including but not limited to cocaine, amphetamines, opiates, sedatives, benzodiazepines and hallucinogens) or any medication or condition that could make participation dangerous to the subject or to others, or affect the results;
• Use of antibiotics in the 4 weeks prior to the start of the study;
• History or diagnosis of alcohol use disorder or binge drinking (4 or more drinks for women and 5 or more drinks for men within a 2-hour window);
• Severe trauma or surgical event within 3 months of screening;
• Of Eastern descent or with a history of alcohol-induced flushing reaction;
• Reluctance or inability to comply with experimental procedures;
• Known intolerance, sensitivity, or allergy to any study product ingredients;
• Extreme dietary habits, as judged by the investigator (ie Atkins diet, very high protein diets, etc.);
• Change in body weight of &gt;3.5 kg within 4 weeks after the screening appointment;
• Presence of any signs or symptoms of active infection in the 5 days prior to any test visit. If an infection occurs during the study period, testing visits should be rescheduled until all signs and symptoms have resolved and any treatment (ie antibiotic therapy) has been completed at least 5 days prior to each visit. test.
• History of cancer within the last two years, except for non-melanoma skin cancer."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-4v65wb8	How food education programs impact the knowledge of nutrition, nutritional status and quality of food for the elderly	Terminated	Intervention	2021-11-12	<NULL>	<NULL>	5043	Effect of different food education programs on knowledge in Nutrition, nutritional status and food consumption of the elderly: a randomized field trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2018-12-15	Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA	Banco de Alimentos do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-4v65wb8	<NULL>	"Individuals aged 60 years and over.
Residents of the city of Porto Alegre, Rio Grande do Sul.
Elderly people who participate in social groups in institutions served by the Food Bank."	Elderly people from groups who have already participated in food education activities of Banco de Alimentos Projects.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-4j62jv6	Comparison of different ways to insert the Copper IUD in women after vaginal delivery	Not yet recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5044	Comparison of Copper Intrauterine Device Insertion Methods in the immediate postpartum	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Hospital da Mulher Prof. Dr. J. A. Pinotti-Caism/Unicamp	Faculdade de Ciências Médicas da Universidade Estadual de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-4j62jv6	<NULL>	Pregnant women between 18 and 43 years old; hemoglobin greater than 8.0 mg/dl during prenatal care; single pregnancy; desire to use IUD as a contraceptive method	Pregnant women with diagnosis or suspicion of ovular membrane infection; diagnosis of any other infection (anywhere); active sexually transmitted infection; uterine malformation (bicornuate, septate uterus); uterine fibroids that deform the cavity; pregnant women with scheduled cesarean	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-105wyncc	Platelet rich plasma and hyaluronic acid in shoulder tendon injuries	Not yet recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5045	Use of platelet rich plasma and hyaluronic acid in rotator cuff injuries	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-12-27	Prevent Senior	Prevent Senior	https://ensaiosclinicos.gov.br/rg/RBR-105wyncc	<NULL>	Adults aged between 40 and 85 years, regardless of gender; clinical and radiological diagnosis of tendinopathy or partial bursal lesions &lt;50% of the supra and infraspinatus thickness; availability of follow-up during the study period; provided voluntary written consent to participate in the study, confirmed by signing the informed consent form	Having other joint diseases or joint trauma, autoimmune diseases or intra-articular medication in the last 12 months; history of acute or chronic communicable diseases, including hepatitis B, hepatitis C and HIV; history of systemic bone or cartilaginous disorders; evidence of active infection or history of infection in the joint to be infiltrated in this study; comorbidity that the physician considers as a contraindication for the infiltration of platelet-rich plasma; chronic treatment with anticoagulant or immunosuppressive drugs; previous surgery (at any time) of the affected shoulder; presence of at least one of the following diseases: adhesive capsulitis, calcareous tendonitis, glenohumeral arthrosis or acromioclavicular joint disease	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-9sh4jcg	Evaluation of needling sensation between acupuncture-experienced and non-acupuncture-experienced	Recruitment completed	Intervention	2021-11-12	<NULL>	<NULL>	5046	Evaluation of deqi sensation between acupuncture-experienced and non-acupuncture-experienced	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-07-01	Faculdade de Odontologia de Piracicaba	Faculdade de Odontologia de Piracicaba	https://ensaiosclinicos.gov.br/rg/RBR-9sh4jcg	<NULL>	People aged 18 years or over; both sexes	People being treated with analgesic and anti-inflammatory drugs; pregnant women; individuals with needle phobia	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-98tx28b	Effect of different foods on blood glucose in Type 2 Diabetes patients	Data analysis completed	Intervention	2021-11-12	<NULL>	<NULL>	5047	Acute glycemic response after adding different foods to breakfast of Type 2 Diabetics	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2019-06-03	Universidade de Brasília - Faculdade de Ceilândia	Secretaria de Estado de Saúde do Distrito Federal	https://ensaiosclinicos.gov.br/rg/RBR-98tx28b	<NULL>	Eligibility criteria included the following: male, type 2 diabetic (American Diabetes Association, 2019), age 30–60 years, regular breakfast consumer (≥100 kcal ingested within 2 h of waking on ≥4 d/ week), willingness to eat all test foods, no self-reported allergy to the foods provided in the study, and no self-reported sleep disorders.	Were excluded the participants in use of exogenous insulin, with diabetes health complications, with reported gastrointestinal disorders or irregular intestinal rhythm, and smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-6q2wx4t	Analysis of the effectiveness of exercises performed in water on the memory of healthy elderly	Not yet recruiting	Intervention	2021-11-12	<NULL>	<NULL>	5048	Analysis of the effectiveness of aquatic physiotherapy on cognitive processes in healthy elderly	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-10	Universidade Federal Mato Grosso do Sul	Universidade Federal Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6q2wx4t	<NULL>	Sedentary elderly, of both sexes, aged between 60 and 90 years old, living in the municipality of Campo Grande / MS and who do not have neurological or psychiatric disorders	Elderly people with cognitive decline (associated or not with dementia), heart disease participants, subjects with fecal incontinence, unable to remain in orthostatism and people with difficulties in understanding the tests. Participants who have more than four consecutive absences in therapies, hydrophobia and a recent crisis of labyrinthine dysfunction will also be excluded from the research	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-75dvnfm	Use of Technology for the practice of physical exercise in the elderly in the community	Recruiting	Intervention	2021-11-10	<NULL>	<NULL>	5030	"Technology as a means of intervention for the practice of physical exercise: clinical trial
randomized with community elderly"	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-09-13	Universidade Católica de Brasília	Universidade Católica de Brasília	https://ensaiosclinicos.gov.br/rg/RBR-75dvnfm	<NULL>	Elderly people over 60 years of age, of both sexes, vaccinated against COVID-19 (with a complete vaccination schedule), with visual, auditory and motor skills to handle the mobile device (smartphone) , who have a smartphone, who have not exercised regularly for three months. In addition, those who achieve the minimum score on the Mini Mental State Examination (MMSE) will be included.	Elderly people of both sexes who are bedridden, who are unable to maintain an orthostatic position, elderly people with flu-like symptoms, who have low visual acuity and hearing impairment (who do not use equipment that minimize deficits) who are unable to walk independent (elderly people who use devices for locomotion, such as a cane, for example, may participate). Elderly people who do not have internet, those who live alone, and those who miss more than 25% of the exercise program will also be excluded. As a precaution, elderly people who were affected by Coronavirus, presenting severe manifestations and requiring hospitalization with invasive mechanical ventilation, will be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-739987q	Nail growth among elderly women under oral collagen: a placebo-comparative study.	Not yet recruiting	Intervention	2021-11-10	<NULL>	<NULL>	5031	Evaluation of nail physiology in elderly women supplemented with hydrolyzed oral collagen: a randomized, double-blind, placebo-controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-05-12	Faculdade de Medicina de Botucatu (FMB Unesp)	Faculdade de Medicina de Botucatu (FMB Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-739987q	<NULL>	Women with more than 60 years; residents of the Botucatu-SP region; who agreed to participate in the study	Immunocompromised women or those using immunosuppressive drugs; diabetics; using anticoagulants or coagulation disorders; using oral retinoids; vegetarians; in protein supplementation; with kidney diseases; thyropathies and nail diseases and current clinical diagnosis will not be included previous or evidence of any medical condition that exposes the patient to increased risks or interferes with the safety or efficacy of the proposed treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-79jpg98	Instrumental myofascial release in submission athletes.	Recruiting	Intervention	2021-11-10	<NULL>	<NULL>	5034	The effectiveness of instrumental myofascial release to muscle recovery in submission athletes: controlled randomized study.	<NULL>	2, randomized-controlled, single-blind	2	<NULL>	<NULL>	<NULL>	2021-08-18	Instituto de Pesquisa e Ensino do Hospital HOME	Instituto de Pesquisa e Ensino do Hospital HOME	https://ensaiosclinicos.gov.br/rg/RBR-79jpg98	<NULL>	Male individuals; age group between 18-40 years; minimum practice time of two years; blue band minimum graduation; average frequency of three weekly training sessions and competitions per year.	"Those who answer “YES” to any question on the Physical Activity Readiness Questionnaire (PAR-Q) will not be included; have any inflammatory disease or have taken anti-inflammatory medication during the past four weeks; present neuromuscular disorders; present handgrip strength less than 40 Kgf; and report of musculoskeletal injury in the last six months.
Those who fail to participate in any stage of the study will be excluded."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-10fwcndv	Evaluation of Systemic Blood Irradiation with Laser (ILIB) and Laser Therapy in the prevention and treatment of Saliva Loss in Cancer Patients	Recruiting	Intervention	2021-11-10	<NULL>	<NULL>	5035	Evaluation of Intravascular Blood Irradiation with Laser (ILIB) and Photobiomodulation in the prevention and treatment of Salivary Hypoflow in Oncological Patients	<NULL>	2, randomized-controlled, double-blind	2	<NULL>	<NULL>	<NULL>	2021-04-10	Roberta Mariano de Carvalho e Silva	Pontifícia Universidade Católica de Campinas	https://ensaiosclinicos.gov.br/rg/RBR-10fwcndv	<NULL>	Volunteer patients; diagnosed with head and neck SCC; older than 18 years; in the 1st week of treatment with curative radiotherapy associated or not with chemotherapy.	Patients under 18 years of age; intubated; who did not start radiotherapy or chemoradiotherapy; palliatives for cancer treatment; with total loss of the maxilla or mandible due to the tumor.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-6y69tqv	Video Game Use in Hospitalized Individuals	Recruiting	Intervention	2021-11-09	<NULL>	<NULL>	5028	"Implementation of Immersive Virtual Reality in individuals hospitalized in service
emergency hospital"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Universidade do Oeste Paulista	Universidade do Oeste Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6y69tqv	<NULL>	Patients aged 43 years or over, of both genders, with heart failure, admitted to the emergency room and with a prescription for motor and respiratory physiotherapy will be included.	Patients with mean arterial pressure &lt; 65 or &gt; 120 millimeters of mercury (mmHg), heart rate &lt; 50 or &gt; 140 beats per minute (bpm), need for vasoactive medication, respiratory rate &gt; 35 inspiration per minute (ipm) will be excluded from the study , acute clinical worsening, sleepy, uncooperative or unable to follow commands, individuals in contact precaution and in orotracheal intubation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-7d6qr5f	Effects of muscular strength, balance, flexibility, agility and coordination exercises and calcium vitamin ingestion on the function of the muscle / bone of older wonen with osteoporosis	Recruiting	Intervention	2021-11-09	<NULL>	<NULL>	5029	Effects of multicomponent exercise and vitamin D and calcium supplementation on musculoskeletal function and risk of falls in older women with osteoporosis: randomized controlled clinical trial (VITADEX study)	<NULL>	3, randomized-controlled, open	3	<NULL>	<NULL>	<NULL>	2021-09-20	Complexo Hospital de Clínicas da Universidade Federal do Paraná	Universidade Federal do Paraná	https://ensaiosclinicos.gov.br/rg/RBR-7d6qr5f	<NULL>	Elderly women; 65 years of age or above on the day of the initial assessments; resident in Curitiba-PR-Brazil; with a diagnosis of osteoporosis by dual energy x-ray (DEXA); able to walk independently a 8 meter flat course, with or without any assistive equipment; presenting a cognitive score in accordance with the Mini Mental state (score 24) regarding the presence or absence of prior formal schooling; not having neurological diseases and/or orthopedic traumas that may prevent the evaluation and exercises execution; not having severe deficiencies (cardiac, respiratory, hepatic, renal, and decompensated hypertension Blood pressure (140 and 90 mmHg); not having any neurologic or trauma-orthopedic diseases with fixations or prostheses with metallic or non-metallic implants, which may prevent the performance of the proposed evaluations or exercises; not having had prior history of upper extremities and Lower Extremity and or spine fracture in the last 4 months or that may impair their performance in the proposed evaluations and  exercises; Visual assessment by the Snellen card presenting (score 20 and 70 unilateral), in case of visual impairment, an adequate corrective instrument should be used (glasses or lenses); not having been involved in any regular resistance exercise program in the last 6 months.	Previous history of fractures of the upper and lower limbs and or spine in the last 4 months; presenting metabolic instability or decompensated cardiovascular disease; having inflammatory and or autoimmune diseases, acute or terminal disease; cancer. Present neurological diseases; osteomalacia; presenting unstable or exercise-induced angina pectoris or myocardial ischemia; presenting type 1 diabetes mellitus; presenting previous diagnosis of: hypercalciuria, hyperparathyroidism, desabsorptive syndromes; using anabolic steroids (for example: synthetic testosterone, Growth hormone (GH);  growth factor I (IGF-I) taking part in a regular physical training program; using antiretrovirals and/or anticonvulsants and/or immunosuppressant drugs and/or corticosteroids; making use of current daily or last year alcohol intake above 25g/day; having severe deficiencies (cardiac, respiratory, hepatic, renal, and decompensated hypertension  above 140 and 90 mmHg); previous diagnosis of diseases such as: heart valve moderate stenosis, chronic obstructive lung disease (COLD) with Forced expiratory volume (FEV-1) lower 50% previously diagnosed, hypothyroidism with altered levels of thyroid stimulating hormone (TSH) or  free thyroxine (T4)T4; hypo or hyper cortisolism; chronic kidney disease with glomerular filtration rate estimated below 30ml/min.1.73m2 according to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI).equation; infectious-contagious disease; human immunodeficiency vírus (HIV), hepatitis, and diabetes mellitus with lesions in the target organ of any gravity and difficult to control clinically; using two or more hypoglycemic drugs; insulin therapy or with glycated hemoglobin (HbG) higher 8.5%; patients who  experienced clinical complications requiring hospitalization or an emergency unit within the 90 days preceding the evaluations of the study protocol or who were bedridden for the same period, and patients with the following conditions: using medications that could alter body composition or physical performance, any clinically decompensated chronic disease, neurological disease, except for osteoporosis, pregnancy.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-75n8453	Less invasive eyebrow lift for treatment of mild to moderate eyebrow tail drop	Recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5020	Minimally invasive eyebrow elevation for the treatment of mild to moderate brow tail ptosis	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2020-03-02	Fundação Santa Luzia	Fundação Santa Luzia	https://ensaiosclinicos.gov.br/rg/RBR-75n8453	<NULL>	Women; Age between 18 and 70 years old; Diagnosis of superior dermatochalasis and mild to moderate ptosis of the eyebrow tail that will undergo superior blepharoplasty surgery at Fundação Santa Luzia, Recife-Pernambuco; Release for surgery by preoperative blood count, coagulogram, fasting blood glucose and favorable cardiac opinion; Signing of the Informed Consent Form (TCLE)	Occurrence of congenital or acquired ocular or periorbital pathology, bulbar atrophy, and/or strabismus; Pregnancy or lactation periods; History of bleeding tendency; Processes or general medical conditions that contraindicate surgery; Patients who have undergone botulinum toxin cosmetic procedure or eyebrow filling in the past year.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-10br88dj	Evaluation of auriculotherapy associated with standard treatment in diabetic patients	Not yet recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5021	Evaluation of the auriculotherapy effectiveness associated with standard treatment for patients with Diabetes Mellitus type II: Pragmatic, randomized, double-blind, multicenter clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade Federal de Santa Catarina	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-10br88dj	<NULL>	Age 18 years or older diagnosed with Type 2 Diabetes Mellitus	Body mass index greater than 30, amputees and on dialysis	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-107ynv85	Wires as an alternative to screws for bunion correction surgery: a randomized clinical trial.	Not yet recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5022	Kirschner wires as an alternative to cannulated screws for hallux valgus correction using the minimally invasive chevron-Akin technique: a randomized clinical trial.	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-09	Universidade Federal do Pará	Hospital Maradei	https://ensaiosclinicos.gov.br/rg/RBR-107ynv85	<NULL>	- Patients of both genders; - Patients undergoing minimally invasive surgery, using the chevron-Akin technique, for moderate or severe hallux valgus correction; - Patients without previous history of surgery for hallux valgus correction; - Patients who failed conservative treatment; - Absence of instability of the first tarsometatarsal joint, defined as abnormal painful movement; - Absence of osteoathritis of the metatarsophalangeal joint of the hallux; - Absence of concomitant deformities of the hindfoot and midfoot; - Absence of rheumatological and neurological diseases.	- Patients who do not attend their return appointments; - Participants who request their removal from the research by their own initiative; - Death due to a reason unrelated to the complication of surgery during the follow-up.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-7pkypg3	Possible Effects of an Osteopathy care on mobility, balance and gait in people with Parkinson&apos;s Disease	Not yet recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5023	"Possible Effects of an Osteopathic Manipulative Treatment Session on
mobility, balance and gait in patients with Parkinson&apos;s Disease"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-04	Universidade Federal do Rio de Janeiro	Instituto de Neurologia Deolindo Couto - INDC	https://ensaiosclinicos.gov.br/rg/RBR-7pkypg3	<NULL>	Adults with idiopathic Parkinson&apos;s disease diagnosed by a neurologist; Patients classified into stages 1 to 3 of disability on the Modified Hoehn &amp; Yahr scale; Being on stable antiparkinsonian medication; Montreal Cognitive Assessment (MoCA). No specific cutoff point will be adopted, but identification, by the evaluator, of the patients&apos; ability or not to obey verbal commands.	Presence of other associated neurological diseases; Important change in understanding and carrying out the tasks present in the MoCA; Rheumatic diseases in the acute phase; Previous history of spinal surgeries using osteosynthesis and arthrodesis-type procedures; Patients classified as stages 4 and 5 of disability on the Modified Hoehn &amp; Yahr scale.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-74wcnjc	Effect of using the Peanut Ball on labor: a randomized clinical trial	Not yet recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5024	Effects of an exercise protocol with the aid of a peanut ball during labor without analgesia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-01-01	Universidade de Pernambuco	Universidade de Pernambuco	https://ensaiosclinicos.gov.br/rg/RBR-74wcnjc	<NULL>	Pregnant with single gestation; above 37 weeks; fetal cephalic presentation; usual gestational risk; over 18 years of age	Volunteers who present some complication during labor; admitted for labor induction	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-2pbbrvg	Evaluation of histological measurement of different graft associations in maxillary sinus after surgery for sinus cavity elevation in antral cavities	Data analysis completed	Intervention	2021-11-08	<NULL>	<NULL>	5025	Histomorphometric evaluation of different graft associations for maxillary sinus elevation in antral cavities	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2020-01-13	Faculdade São Leopoldo Mandic	Associação Brasileira de Odontologia - MT	https://ensaiosclinicos.gov.br/rg/RBR-2pbbrvg	<NULL>	The study included patients older than 18 years, without pathologies of the maxillary sinus, with maxillary sinuses classified as wide (Chan et al. 2014), and with a posterior bone height below 3 mm in the 2nd premolar and 1st molar region.	The exclusion criteria applied were patients with a chronic disease that would contraindicate the surgical procedure, such as uncontrolled diabetes, hypertension and head/neck radiation, smokers (more than 5 cigarettes per day), and patients with habits that could interfere with the treatment, such as alcoholism and drug use, use of prolonged bisphosphonate therapy, and/or a history of previous surgical procedure for maxillary sinus graft.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-5vg8p36	Study of the Benznidazol blood levels in chronic use in Patients with Chronic Chagas Disease Indeterminate Form – Relationship with sex, age, and adverse events and implications for future trials for combination therapy of Chagas Disease	Recruiting	Observational	2021-11-08	<NULL>	<NULL>	5026	Study of the pharmacokinetic profile in a multiple dose scheme for the drug Benznidazole in patients with Chronic Chagas Disease Indeterminate Form – Relationship with demographic profiles and adverse events and implications for future trials for combination therapy of Chagas Disease	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-06-17	Fundação Oswaldo Cruz	Fundação Oswaldo Cruz	https://ensaiosclinicos.gov.br/rg/RBR-5vg8p36	<NULL>	Adult patients with Chagas disease indeterminate form of both sexes, aged between 18 and 70 years old.	Patients with a history of previous treatment with benznidazol (BZ), contraindications or hypersensitivity to the use of BZ, renal or hepatic failure, gastrointestinal disorders or other condition that interferes with the processes of absorption, distribution, excretion or metabolism of the drug, pulmonary, epileptic, hematological or psychiatric, pregnancy or lactation, associated heart disease such as moderate or severe orovalvular disease, ischemic, congenital or hypertensive heart disease, comorbidities such as malignant tumors and HIV infection, cognitive limitation that does not allow the correct understanding of the IC and the stages of the project, individuals participating in other investigations with interventions, using three or more medications of regular use within the 02 weeks prior to the start of the study treatment, except contraceptives (for women), omeprazole and simvastatin, or any eventual medication within 07 days before the start of study treatment, except dipyrone and paracetam ol, with a history of treatment within the 3 months prior to the study with any drug with known toxic potential in large organs. Participants with a history of loss or donation of 450 mL or more of blood within the three months prior to the scheduled visit date will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-66dr73f	The quality of life of women with Arthrosis using Arnica gel.	Recruitment completed	Intervention	2021-11-08	<NULL>	<NULL>	5027	The quality of life of women  with Osteoarthritis using Arnica gel (Lychnophora pinaster Mart)	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-03-01	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-66dr73f	<NULL>	age 40 years or older; female, due to the higher prevalence of the disease; and clinical diagnosis of knee osteoarthritis according to the American College of Rheumatology (ACR) classification.	those who had: contraindications to the use of therapeutic ultrasound such as, area with hypoesthesia, area with vascular insufficiency, affections located in the tissue, diabetes mellitus, open wounds; hypersensitivity and allergy to Arnica or Diclofenac and its components; rheumatologic conditions such as rheumatoid arthritis; severe knee OA and lower limb thrombosis; who performed injections in the knee joint in the last 6 (six) months; balance disorders, neuropathy or sensory disturbances and skin lesions around the knee; who had undergone previous surgery on the knee joint or suffered a fractured knee joint.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:51
RBR-1056fgjk	Effect of Telenursing on the Sexuality of women with Breast Cancer	Recruiting	Intervention	2021-11-08	<NULL>	<NULL>	5608	Telenursing in the Sexual Function of women with Breast Cancer: clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Universidade Federal do Ceará	Universidade Federal do Ceará	https://ensaiosclinicos.gov.br/rg/RBR-1056fgjk	<NULL>	Women with breast cancer in stages I-IV; Being on cancer treatment (chemotherapy, radiotherapy or hormone therapy) for at least six months, as a survey showed that the majority (66%) of patients develop sexual problems during the treatment of breast cancer and not after (22%) (HUMMEL et al, 2017); Have at least one telephone contact to receive the intervention; Having a partner.	Treatment of another type of cancer; Having hearing impairment, as it makes communication via telephone impossible, which will be assessed through the Whisper Test (LABANCA et al, 2017); Participate in any intervention for the treatment of sexual dysfunction or climacteric, since the comparison between the control group and the intervention group occurs in the best way when there are no co-interventions (drugs, therapies or behaviors) that alter the risk of developing / altering the outcome of interest (HULLEY et al, 2015); Women with mental restrictions, confirmed by medical diagnosis, which makes it impossible to understand the instruments.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-6zndpbv	Individual mindfulness-based cognitive therapy for treatment-resistant depression	Recruitment completed	Intervention	2021-11-05	<NULL>	<NULL>	5017	Evaluation of the effectiveness of an individual mindfulness-based cognitive therapy (MBCT) protocol for patients with resistant depression: a randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-11-15	Universidade Federal do Rio de Janeiro	Universidade Federal do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-6zndpbv	<NULL>	moderate to high level of current depressive symptoms; beck depression inventory (BDI); BDI less than 20	current psychotic symptoms; bipolar disorder; previous Mindfulness training	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-4q6dtvw	Comparison between the effect of two analgesics on sedation in surgeries in children who fractured the upper limb	Recruitment completed	Intervention	2021-11-05	<NULL>	<NULL>	5018	Comparasion between Fentanyl and Ketamine in the intra-operative sedation of children submitted to orthopedic procedures in upper limb	<NULL>	4, randomized-controlled, double-blind	4	<NULL>	<NULL>	<NULL>	2021-01-02	Universidade de Fortaleza - Unifor	Universidade de Fortaleza - Unifor	https://ensaiosclinicos.gov.br/rg/RBR-4q6dtvw	<NULL>	Children aged between 24 and 192 months. Both genders. Undergoing a surgical procedure for correction of upper limb fractures. No major comorbidities.	Allergy to some medication used in the study. Chronic use of sedatives or analgesics. Previous neurological or motor deficits. Use of alcohol or drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-4bj4tgd	Polydioxanone threads in the treatment of facial melasma	Recruitment completed	Intervention	2021-11-05	<NULL>	<NULL>	5019	Polydioxanone threads in the treatment of facial melasma: a proof of concept study	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-02	Faculdade de Medicina de Botucatu (FMB - Unesp)	Faculdade de Medicina de Botucatu (FMB - Unesp)	https://ensaiosclinicos.gov.br/rg/RBR-4bj4tgd	<NULL>	Women over 45 years old, with facial melasma affecting the zygomatic region bilaterally and another area of the face (control) and phototypes II to V (Fitzpatrick). Participants must avoid sun exposure during the study period.	Pregnant and lactating women; individuals who are using other clarifying substances and those who refuse to be photographed; women who work with photo exposure; carriers of autoimmune diseases; menopausal women;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-2nmwxwt	Does a new mechanical ventilation strategy in the immediate postoperative period of cardiac surgery reduce pulmonary complications and is it capable of optimizing the functional capacity of patients at hospital discharge?	Recruitment completed	Intervention	2021-11-05	<NULL>	<NULL>	6846	Alveolar recruitment with peep titling in the immediate post-operative of cardiac surgery reduces pulmonary complications and is it able to optimize the functional capacity of patients in hospital discharge? A randomized controlled clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2023-11-30	Hospital Universitário Pedro Ernesto (HUPE)	Hospital Universitário Pedro Ernesto (HUPE)	https://ensaiosclinicos.gov.br/rg/RBR-2nmwxwt	<NULL>	Patients aged 18 years or over, undergoing elective cardiac surgery for valve replacement (VT) or myocardial revascularization (MVR) or VT with CABG; surgery in the ascending Aortic Artery associated with cardiac surgery; correction of atrial septal defect (ASD); correction of interventricular communication (IVC) with programmed use of cardioplumonary bypass (CPB), clamping of the aorta artery, use of cardioplegia and conventional median sternotomy or median ministernotomy, volume adjusted to an inferior vena cava (IVC) measurement above 18 mm and mean arterial pressure ( MAP) greater than 80 mmHg.	Patients who refuse to participate in the study will be excluded; patients with previous cardiac surgery; pulmonary fibrosis; pulmonary emphysema; pneumonia diagnosed in the last 30 days; patients with pulmonary artery hypertension, with pulmonary artery systolic pressure greater than 45 mmHg; need for orotracheal intubation before arrival in the operating room; obese with body mass index (BMI) greater than 40 kg/m2; need for noradrenaline greater than 2 μg/kg/min; need for re-operation; pneumothorax and/or bubbling drains; patients with neuromuscular disease; myocardial revascularization surgery (CRVM) using a right internal mammary artery (MID) and radial artery graft.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-107jk4tn	Effects of low-carbohydrate diets in the treatment of chronic diseases	Recruiting	Intervention	2021-11-03	<NULL>	<NULL>	5012	Effects of low-carbohydrate diets in the treatment of chronic non-communicable diseases.	<NULL>	n/a, single-arm-study, open	N/A	<NULL>	<NULL>	<NULL>	2021-03-01	Amanda Aparecida Felizardo	Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-107jk4tn	<NULL>	Have a diagnosis of type 1 diabetes Mellitus; present from 21 to 50 years of age of both sexes; have glycated hemoglobin (Hb1Ac) &gt;7.0%; agree to follow all parameters considered in the protocol for the treatment of type 1 diabetes with a low-carbohydrate diet; belong to any region of the country; have creatinine clearance &lt; 60; use a glucometer or sensor (Libre, Flash Glucose Monitoring) for minimum of 7 measurements per day; perform a fundus examination for the diagnosis of diabetic retinopathy; have mild retinopathy treated (to be evaluated by the ophthalmologist and endocrinologist); be willing to consume, during the first 15 days of the protocol, the amount of 130g of daily carbohydrates; sign the authorization to participate in the research through the Informed Consent Form (TCLE); agree to perform all laboratory tests before starting the survey, three months after the start of the 50g daily carbohydrate phase, and at the end of the sixth month of the survey.	Have moderate to advanced diabetic retinopathy (to be evaluated by the ophthalmologist and endocrinologist); present reports or suspicion of gastroparesis; have an eating disorder, such as binge eating; be an athlete; use an insulin pump; have a pregnancy diagnosis.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-9r769bf	Effects of Low-level Laser Therapy on the performance of the gluteus medius muscle	Recruitment completed	Intervention	2021-11-03	<NULL>	<NULL>	5013	Effects of Low-level Laser Therapy on the performance of the gluteus medius muscle	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-10	Universidade Estadual Paulista	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-9r769bf	<NULL>	healthy individuals; women; age; BMI; individuals active according to the International Physical Activity Questionnaire; availability to participate in the intervention	Cardiovascular or neurological or disease; such as spine or knee pathologies; absolute contraindication for phototherapy, male, above 24 (age)	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-4y7yyfs	Effects of circuit strength training on exercise energy expenditure, appetite, and food intake in post-stroke patients with partial body part paralysis	Recruiting	Intervention	2021-11-03	<NULL>	<NULL>	5014	Acute effects and reproducibility of circuit resistance training session on energy expenditure, appetite and energy intake in patients with stroke sequelae	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-08-05	Universidade do Estado do Rio de Janeiro	Universidade do Estado do Rio de Janeiro	https://ensaiosclinicos.gov.br/rg/RBR-4y7yyfs	<NULL>	Right or left hemiparesis, with at least six months of the occurrence of stroke; be able to walk without supervision for home walking; enrolled in a neuro-motor rehabilitation program; score above 36 on the Berg balance scale; minimum score of 50 on the Fulg-Meyer scales; signature of the written informed consent form.	Smoking; history of drug or alcohol abuse; using beta-blockers, neuroleptics or medications that alter the threshold excitement of the neuronal membrane; hormone replacement therapy; head trauma; metallic prosthetic device in the skull; evidence of secondary hypertension; diagnosed with metabolic, liver, cardiac, oncological, psychiatric, neurological pathologies; body mass index &lt;25 or&gt; 35 kg / m2. g) Estimated glomerular filtration rate &lt;60 mL/min; h) Acute or chronic hepatic disease with transaminases &gt;3x upper reference value; i) Patients with clinical evidence of coronary disease with a history of angina or tests compatible with myocardial ischemia; j) Previous history of acute myocardial infarction and/or myocardial revascularization; k) Clinical signs of heart failure, symptomatic cardiac arrhythmia or clinically significant valve disease; l) Patients with a history of drug or alcohol abuse in the last 10 years; m) Patients with a history of cancer in the last five years; n) History of neurological or psychiatric disease (e.g. epilepsy); o) History of cranial trauma at any age or existence of a metal prosthetic device or other metal particle in the skull.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-97fxm4g	Menorrhagia Control with Two Hormonal IUDs	Recruiting	Intervention	2021-11-03	<NULL>	<NULL>	5015	Heavy Menstrual Bleeding Control with Two Levonorgestrel Intrauterine Systems: A Double-Blind, Randomized Clinical Trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-07-16	CAISM - Centro de Atenção Integral à Saúde da Mulher	CEMICAMP	https://ensaiosclinicos.gov.br/rg/RBR-97fxm4g	<NULL>	Women with age between 18 years (complete) - 48 years (incomplete); heavy menstrual bleeding (menorrhagia).	Pregnancy; illicit drugs; anticoagulation therapy; recent deep venous thrombosis; coagulopathy; cancer; pelvic inflammatory disease; uterine malformation; polyp or intrauterine fibroid; uterine bleeding of unknown origin; refusal to sign the informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-8kmydzj	Impact of topical testosterone on lipid profile in women with decreased sexual desire: A randomized controlled double-blind study.	Data analysis completed	Intervention	2021-11-03	<NULL>	<NULL>	5016	The impact of transdermal Testosterone Nanoemulsion on lipid profile in women with Hypoactive Sexual Desire: A double-blind randomized controlled study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2018-07-05	universidade federal de sao paulo	universidade federal de sao paulo	https://ensaiosclinicos.gov.br/rg/RBR-8kmydzj	<NULL>	Inclusion criteria:Women over 18 years old; maximum age 45 years; Decreased sexual desire; Present sexual activity, with at least one sexual event per month, with current partner; Be in good general health; Women over 40 should have a clinically acceptable mammogram within the last 2 years; Be on contraceptive method.	Exclusion Criteria:Sexual dysfunction caused by another medical condition;Body mass index (BMI) below 18 kg / m2 or above 35 kg / m2; undiagnosed genital bleeding;Use of androgen therapy in the last 6 months (testosterone implant, testosterone transdermal cream, tibolone, oral testosterone or injectable testosterone); Antiandrogenic therapy for acne or hirsutism in the last 5 years; Hyperandrogenism Syndrome, such as Polycystic Ovary Syndrome; Moderate or severe acne, hirsutism, and androgenetic alopecia; Any serious clinical or psychiatric illness, active cancer, or treatment of malignancy within the last six months; Decompensated clinical disease; Any clinically significant skin abnormalities in the study medication application area; Consumption of more than three standard alcoholic drinks per day; pregnancy or lactation; Do not attend our center for follow-up study visits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-8cjjpgm	Assessment of the impact of sanitation on the prevention of urban leptospirosis.	Recruiting	Intervention	2021-10-31	<NULL>	<NULL>	5010	Improved sanitation interventions to prevent urban leptospirosis transmission	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-16	Wellcome Trust	Instituto de Saúde Coletiva (ISC) - UFBA	https://ensaiosclinicos.gov.br/rg/RBR-8cjjpgm	<NULL>	Sleeping ≥3 nights a week in a study household; They are ≥18 years old for leptospirosis study and between 0.6 month to 17 years to exploratory outcomes; living in the area for at least 6 months; understand and agree to participate in the study by signing the informed consent procedures. Participants who agree to use GPS for 24 hours in order to monitor their movements; signing a specific informed consent procedure.	Residents who being less than 18 years old (For the Leptospirosis study); residents that sleep less than 3 nights a week in a residence on site; residents who refuse or are unable to provide information, biological sample collection; residents who do not provide written informed consent to participate in the study; residents with limited mental health problems or other problems that have implications for survey responses or participation in any other phase of research activity; legal guardians who do not agree, in writing, with the participation of individuals under 18 years of age; residents with reduced mobility due to physical and mental conditions, which do not allow displacement to the neighborhood or other places in the community (previous or during the data collection period).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-7yh6jk8	Manual treatment for mouth pain	Not yet recruiting	Intervention	2021-10-30	<NULL>	<NULL>	5009	Osteopathic Treatment in Patients with Temporomandibular Disorder	<NULL>	2-3, randomized-controlled, single-blind	2-3	<NULL>	<NULL>	<NULL>	2021-11-13	ESCOLA DE OSTEOPATIA DE MADRID - BRASIL LTDA	ESCOLA DE OSTEOPATIA DE MADRID - BRASIL LTDA	https://ensaiosclinicos.gov.br/rg/RBR-7yh6jk8	<NULL>	Both sexes; be over 18 and have a maximum age of 45; not having used orthodontic braces; do not use fixed or mobile dental prostheses; not having rheumatic disease; not using analgesics; not have fibromyalgia.	Minor; be over 45 years old; fibromyalgia patient; have rheumatic disease, use daily analgesics, use fixed dental prosthesis; or mobile; having already used orthodontic braces.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-4b8q8tr	Osteopathic manipulative treatment effects to blood circulation of type II diabetics&apos; lower limbs	Recruiting	Intervention	2021-10-28	<NULL>	<NULL>	5007	Hemodynamic effects of osteopathic manipulative treatment on lower limbs of type II diabetics	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-07	Escola de Osteopatia de Madrid - Brasil	Escola de Osteopatia de Madrid - Brasil	https://ensaiosclinicos.gov.br/rg/RBR-4b8q8tr	<NULL>	Men and women; between 18 and 75 years old; diagnosis of type II DM; they must be in traditional care for vascular dysfunction of the lower limbs at the study clinic.	severe osteoporosis; fever; complaints of night pain; progressive neurological deficit; inability to complete the evaluation and neoplasms;	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-48fd64k	Individualized homeopathic medicine efficacy and safety in Covid-19 epidemic	Recruiting	Intervention	2021-10-28	<NULL>	<NULL>	5008	Clinical trial of individualized homeopathic medicine in Covid-19 epidemic treatment and prevention: efficacy and safety evaluation	<NULL>	n/a, randomized-controlled, triple-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-01	Hospital Regional de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-48fd64k	<NULL>	Men and women at least 18 years older with confirmed disease with positive SARS-CoV-2 molecular test (RT-PCR) admitted at Hospital Regional de Mato Grosso do Sul ward with at least one of the following conditions: oxygen saturation less than 95% in ambient air; signs of respiratory discomfort or rise in respiratory frequency evaluated according to age; worsening of underlying disease clinical conditions; hypotension; fespiratory insufficiency.	Viral infections wiht etiological agents other than SARS-CoV-2; negative SARS-CoV-2 molecular test (RT-PCR); other diseases with respiratory tract impairment with negative SARS-CoV-2 molecular test (RT-PCR); need of special treatment and care, such as pregnant women and severe comorbidities (cardiovascular disease, cancer, imunosuppression, HIV and tuberculosis, among others).	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-6n6cdx8	Evaluation of hand movement learning in young adults using a cell phone	Not yet recruiting	Intervention	2021-10-27	<NULL>	<NULL>	5006	Evaluation of motor learning in young adults using a device mobile	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal de Alfenas	Universidade Federal de Alfenas	https://ensaiosclinicos.gov.br/rg/RBR-6n6cdx8	<NULL>	women;declared right;aged 18 to 25 years;without previous experience in the task.	evident and proven signs of aggravation of general health conditions;musculoskeletal changes without right upper limb;sinister laterality.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-5r5cn8j	Music during INJECTION in the eye	Recruiting	Intervention	2021-10-26	<NULL>	<NULL>	5002	Music in the relief of pain and anxiety during Intraviteral Injection: a randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-02	Universidade Federal de Sergipe	Hospital de Olhos de Sergipe	https://ensaiosclinicos.gov.br/rg/RBR-5r5cn8j	<NULL>	Be 18 years of age or older; need one or more consecutive IVI applications for any of these conditions: diabetic macular edema, age-related macular degeneration, or central retinal vein occlusion.	Patients who have already undergone procedures and/or ophthalmic surgery; patients who have chronic pain and make continuous use of pain management medications (NSAIDs, opioids and adjuvant medications); patients who have some type of hearing impairment; patients who report that they do not like listening to music or that it brings negative feelings and memories; patients who have neurological diseases or who are unable to understand the guidelines for measuring pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-9cy75fv	Use of mobile app to decrease gum and dental plaque bleeding in children	Recruitment completed	Intervention	2021-10-26	<NULL>	<NULL>	5003	The influence of a mobile application in the evaluation of bacterial plate index and gengival bleeding index in childrens	<NULL>	n/a, non-randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-06-26	Fundação Hermínio Ometto	Fundação Hermínio Ometto	https://ensaiosclinicos.gov.br/rg/RBR-9cy75fv	<NULL>	Both sexes, 08 to 10 years of age, with predisposition to caries.	Children without neurological, intellectual, systemic alterations; presence of severe fluorosis; hypoplasias; use of fixed orthodontic appliance.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-6gdrq6n	Evaluation of low concentration gels on tooth sensitivity after at-home bleaching	Recruitment completed	Intervention	2021-10-26	<NULL>	<NULL>	5004	Evaluation of dental sensitivity in at-home bleaching with 4% hydrogen peroxide - randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6gdrq6n	<NULL>	Volunteers must be at least 18 years old; presenting good general and oral health; absence of caries and restorations in the upper anterior arch; never had performed dental bleaching; not using analgesics and anti-inflammatory drugs; have upper canines in color A2 or darker according to the Vita Classical scale.	Volunteers using dental prostheses or orthodontic devices; have deep satain due to fluorosis or tratracycline; pregnant or lactating women; volunteers with gingival recession, dentin exposure or the presence of visible cracks in the enemel; parafunctional habits.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-9bbcwn5	Evaluation of patient satisfaction submitted to at-home bleaching with different types of bleaching trays	Recruitment completed	Intervention	2021-10-26	<NULL>	<NULL>	5005	Evaluation of patient satisfaction submitted to at-home bleaching with different types of bleaching trays: randomized single-blind clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-06-11	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-9bbcwn5	<NULL>	Age between 18 and 60 years; good general and oral health; vital healthy teeth; minimum color A2; agree and sign the informed consent form (TCLE).	Whitening procedure previously; previous dental sensitivity; dental prosthesis; fixed orthodontic appliance; restorations in the anterior superior teeth; endodontic treatment on anterosuperior teeth; gingival recessions; teeth stained by tetracycline or fluorosis; visible cracks in the teeth; continuous use of medications; pregnant or lactating women; bruxism; smokers.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-8rrwhfv	Effect of Pelvic Floor Muscle Training using Telephysiotherapy in obese women with reports of urinary loss	Recruiting	Intervention	2021-10-26	<NULL>	<NULL>	5623	Effect of Pelvic Floor Muscle Training using telephysiotherapy  in obese women’s urinary incontinence reports: an assessor blinded randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	Universidade de São Paulo	Coordenação de Aperfeiçoamento de pessoal de Nível Superior	https://ensaiosclinicos.gov.br/rg/RBR-8rrwhfv	<NULL>	Literate women; older than 18 years; with body mass index (BMI) &gt; 30 kg/m2; who agree on participating on the study through signing the TCLE; who are not in the gestation period and postpartum; self reporting  urinary incontinence in the last four weeks (measured by the score &gt; 0 in the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF); who are not engaged in a weight loss treatment It consists of a questionnaire that was translated and validated to Portuguese by Tamanini et al which evaluates the symptoms, UI severity and the impact that UI has in the woman life quality (QoL). It is a short questionnaire that aims to facilitate the data comparison of different studies and to enable a more consistent and unified evaluation of the UI symptoms and its impact on QoL.	Women who do not want to keep participating in the research; withdrawn their consent to participate  in the study	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:13
RBR-6xfz7pc	Consequences of Covid-19 infection in patients hospitalized for the disease: a study with an emphasis on pain	Recruitment completed	Observational	2021-10-25	<NULL>	<NULL>	5001	The impacts of the Covid-19 pandemic on patients affected in moderate and severe forms - an observational study with an emphasis on the presence of Pain	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2020-10-01	Faculdade de Medicina de Botucatu	Faculdade de Medicina de Botucatu	https://ensaiosclinicos.gov.br/rg/RBR-6xfz7pc	<NULL>	Over 18 years old; of both genders; diagnosed with Covid-19 and who needed hospitalization	Patients with cognitive impairment perceived during the interview; with significant visual or auditory changes.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-4c94dtn	Digital psychosocial intervention for older adults with depression	Recruiting	Intervention	2021-10-22	<NULL>	<NULL>	4999	Digital psychosocial intervention for older adults with depression	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Faculdade de Medicina da Universidade de São Paulo	King's College	https://ensaiosclinicos.gov.br/rg/RBR-4c94dtn	<NULL>	Registered with one of the participating clinics or organisations; aged 60 or over; scores of PHQ-2≥1 (first two questions of PHQ-9) and PHQ-9≥10; able to receive live calls and WhatsApp messages (audio and images) on a mobile phone.	Unable to communicate (non-Portuguese speaking, cognitively impaired or other problem hindering communication to engage in trial assessment and intervention such as vision or hearing problems, terminal illness or severe mental illness); individuals presenting suicidal risk during the two weeks prior to the screening assessment, as assessed by the 9th item of the PHQ-9 and Immediate Suicide Risk Protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:50
RBR-3nvsj3z	Diet that mimics Fasting in patients with Breast Cancer treated by SUS: effects on reducing the effects caused, quality of life, progression, metastasis and tumor sensitization	Not yet recruiting	Intervention	2021-10-21	<NULL>	<NULL>	4995	Impact of implementing a Nutritional Protocol that Mimics Fasting in Breast Cancer patients treated by SUS: a proposal on reducing side effects, quality of life, progression, metastasis and tumor sensitization	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-05	Universidade Federal do Piauí	Universidade Federal do Piauí	https://ensaiosclinicos.gov.br/rg/RBR-3nvsj3z	<NULL>	Female patients have a histologically confirmed diagnosis of HER2-negative, early stage II/III breast cancer (cT1cN + or ≥T2 any cN, cM0), and who have not yet started chemotherapy, adequate bone marrow; adequate liver function; adequate kidney function; normal heart function; age ≥18 years; BMI&gt; 19 kg/m2; absence of diabetes mellitus; absence of allergy to MJD and signed consent form.	Previous 5-year malignancy, with the exception of a history of previous basal cell carcinoma of the skin or pre-invasive carcinoma of the cervix; presence of other serious diseases, such as recent myocardial infarction, clinical signs of heart failure or clinically significant arrhythmias; BMI &lt; 19 kg/m2; patient with severe weight loss; pregnancy or breastfeeding; significant food allergies that would make the subject unable to consume the food provided; medical or psychological condition that, in the investigator&apos;s opinion, would not allow the patient to complete the study or sign a meaningful informed consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-9v7bx4h	Effects of the online mindfulness protocol for college students	Recruiting	Intervention	2021-10-21	<NULL>	<NULL>	4996	"Evaluation of the Effects of the Online Version of the MBRP Protocol
(Mindfulness-Based Relapse Prevention) Adapted for University Students."	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-05-11	Universidade Federal de São Paulo	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-9v7bx4h	<NULL>	Undergraduate or graduate university students in the health area, both genders, between 18 and 30 years old who have access to the internet.	Participants who present a clinical situation of psychotic disorder, severe cognitive impairment and/or have already completed a mindfulness group.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-6c7ghfd	Digital care program for older adults with depressive symptoms in primary care	Recruiting	Intervention	2021-10-21	<NULL>	<NULL>	4997	Digital care program for older adults with depressive symptoms in primary care	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-20	Faculdade de Medicina da Universidade de São Paulo	King's College London	https://ensaiosclinicos.gov.br/rg/RBR-6c7ghfd	<NULL>	Registered with one of the participating clinics or organisation; aged 60 or over; scores of PHQ-2 higher than 0 (first two questions of PHQ-9) and PHQ-9 between 5 and 9; able to receive live calls and WhatsApp messages (audio and images) on a mobile phone	Unable to communicate (non-Portuguese speaking, cognitively impaired or other problem hindering communication to engage in trial assessment and intervention such as vision or hearing problems, terminal illness or severe mental illness); individuals presenting suicidal risk during the two weeks prior to the screening assessment, as assessed by the 9th item of the PHQ-9 and Immediate Suicide Risk Protocol	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3hqrvrr	Treatment of multiple gingival recessions using volume-stable collagen-based gingival graft substitute impregnated with blood platelet derivative: a split-mouth randomized clinical trial	Not yet recruiting	Intervention	2021-10-20	<NULL>	<NULL>	4993	Treatment of multiple gingival recessions with volume-stable collagen matrix impregnated by platelet aggregates: a split-mouth randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Universidade Federal de Santa Catarina	Osteology Foundation	https://ensaiosclinicos.gov.br/rg/RBR-3hqrvrr	<NULL>	Patients requiring root coverage for multiple gingival recessions; of both sides of the mouth; in homologous teeth; in the maxillary aesthetic zone (between teeth 15 and 25); without interproximal involvement; with a minimum of three adjacent teeth in each side of the maxilla should present marginal recession at least one of them with a recession depth equal or over 3 millimeters; patients should be equal or over18 years-old; present good oral health.	Uncontrolled systemic or local conditions; diabetic volunteers; pregnant women; volunteers with periodontitis; smokers; volunteers with a history of mucogingival or periodontal surgery at surgical sites; prosthetic crowns at teeth or implants in the surgical sites; gingival recessions with less than 1 mm of keratinized tissue apical to recession areas.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-747wrkx	Analysis of the Effects of Progressive Neuromuscular Training on Pain and Neuromuscular Performance in Elderly Women with Osteoarthritis of the Knee	Recruitment completed	Intervention	2021-10-20	<NULL>	<NULL>	4994	Analysis of the effects of progressive neuromuscular training on pain and neuromuscular performance in elderly women with knee osteoarthritis: clinical, randomized, controlled trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-08-19	Faculdade de Enfermagem Nova Esperança-FACENE	Faculdade de Enfermagem Nova Esperança-FACENE	https://ensaiosclinicos.gov.br/rg/RBR-747wrkx	<NULL>	Elderly women, aged between 60 to 70 years; sedentary; with a clinical diagnosis of knee osteoarthritis according to the classification of Kellgreen and Lawrence Grade II or III (Hunter and Eckstein, 2009); who have not undergone any type of knee surgery; able to walk; who have limited their activities due to fear of falling; agree to participate in the study by signing the Informed Consent Form and who during the assessment do not present vestibular disorders.	Elderly women who present severe pain in the knees during the exercise protocol; as well as reduced mobility to the point of interfering with walking and with less than 25% compliance with the protocol.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-4m3b4b6	Sports intervention with and without context-focused therapy for children and adolescents with Cerebral Palsy	Recruiting	Intervention	2021-10-19	<NULL>	<NULL>	5742	SPORTS STARS Brasil: The effectiveness of a sport-centered group intervention for children and adolescents with Cerebral Palsy with or without context-focused therapy	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-10-28	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - Universidade Federal de Minas Gerais	Escola de Educação Física, Fisioterapia e Terapia Ocupacional - Universidade Federal de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-4m3b4b6	<NULL>	Children from 6 and 12 years of age; diagnosis of Cerebral Palsy; at the levels of the Gross Motor Function Classification system I and II.	severe cognitive and / or behavioral difficulties that make it impossible to demonstrate their preferences, as reported by their parents; have clinical conditions (cardiorespiratory diseases and / or uncontrolled epilepsy) that prevent them from safely participating in activities; post-operative orthopedic and / or neurological surgery in the last six months or planned during the study period.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:18
RBR-2jwy9xf	Auriculotherapy in the treatment of Anxiety in people with HIV	Recruiting	Intervention	2021-10-15	<NULL>	<NULL>	4990	Auriculotherapy in the management of Anxiety symptoms in people living with HIV: randomized clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Federal University of Ceara	Federal University of Ceara	https://ensaiosclinicos.gov.br/rg/RBR-2jwy9xf	<NULL>	People living with HIV; 18 years of age or older; and with a score greater than or equal to 35 on the State-Trait Anxiety Inventory.	Pregnancy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-8rczn6p	Assessment of pain, ease of insertion and clinical performance of three types of intrauterine devices (copper, Mirena® and Kyleena®) in adolescents	Not yet recruiting	Intervention	2021-10-15	<NULL>	<NULL>	4991	Assessment of pain, ease of insertion and clinical performance of three types of intrauterine devices (copper, Mirena® and Kyleena®) in adolescents: partially blind randomized study	<NULL>	4, randomized-controlled, single-blind	4	<NULL>	<NULL>	<NULL>	2021-11-10	Universidade Estadual de Campinas	Universidade de Gurupi- UNIRG	https://ensaiosclinicos.gov.br/rg/RBR-8rczn6p	<NULL>	Women up to 19 years old who want contraception with an IUD, nuligest or with children.	Confirmed or suspected pregnancy. Sexually Transmitted Disease (STD) active. Pelvic inflammatory disease.  Malformation of the uterus or intracavitary myoma that distorts the uterine cavity.Genital bleeding of an unknown nature. Previous surgery in the cervix.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-7fhzpwd	Diamond Peeling Effectiveness Evaluation associated with Vitamin C in Melasma lightening and reduction: a pilot study	Recruitment completed	Intervention	2021-10-15	<NULL>	<NULL>	4992	Microdermabrasion Effectiveness Evaluation associated with Vitamin C in Melasma lightening and reduction: a pilot study	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2020-11-02	Faculdade Ciências Médicas de Minas Gerais	Faculdade Ciências Médicas de Minas Gerais	https://ensaiosclinicos.gov.br/rg/RBR-7fhzpwd	<NULL>	Female participants; aged 20 to 60 years; phototype of grade II, III or IV; epidermal melasma	Pregnant women; lactating women; people with a history of hypertrophic scars and/or keloids; who are undergoing or have already undergone any dermatological treatment in the last 6 months	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-5dhhhdd	Clinical evaluation of the antidepressant effect of the use of probiotics in bipolar disorder	Not yet recruiting	Intervention	2021-10-15	<NULL>	<NULL>	5671	Clinical evaluation of the antidepressant effect of the use of probiotics in bipolar disorder and possible mediating effects of systemic and Intestinal Inflammatory markers in the microbiota	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-11-01	Universidade de São Paulo	Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5dhhhdd	<NULL>	Bipolar disorder type I or type II; score on the YMRS scale less than 8; score on the MADRS scale greater than 8	"Pregnant or lactating women; patients dependent on alcohol and illicit drugs like marijuana, crack or cocaine; patients on prolonged antibiotic therapy; immunosuppressive therapies; introduction of recent antidepressants up to 15 days from the beginning of the study; HIV carriers with manifestations of the syndrome
of acquired immunodeficiency and serious clinical diseases; with delayed mental or inability to understand the study instructions will be excluded"	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:15
RBR-10sxrcrs	The use of needles or tuning forks to reduce stress in nursing professionals	Data analysis completed	Intervention	2021-10-15	<NULL>	<NULL>	6836	Acupuncture and acutone for stress reduction in nursing professionals: pilot study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2023-09-01	Universidade Federal de Santa Catarina	Universidade Federal de Santa Catarina	https://ensaiosclinicos.gov.br/rg/RBR-10sxrcrs	<NULL>	Nursing professionals of both genders, whose scores on the Perceived Stress Scale (≥ 25); who are not using other integrative or complementary health practices; and who are not in psychotherapy or psychiatric treatment	Participants who are not comfortable with needle sticks or tuning forks	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:57
RBR-2vw8282	A study to evaluate the use of eSight magnifying glasses in adults with Low Vision	Not yet recruiting	Observational	2021-10-14	<NULL>	<NULL>	4985	A study to evaluate the use of eSight magnifying glasses in adults with Low Vision	<NULL>	array, array, array	<NULL>	<NULL>	<NULL>	<NULL>	2021-11-01	IPEPO - Instituto Paulista de Estudos e PEsquisas em Oftalmologia	IPEPO - Instituto Paulista de Estudos e PEsquisas em Oftalmologia	https://ensaiosclinicos.gov.br/rg/RBR-2vw8282	<NULL>	lucid, mentally competent and with stable vision in the last 6 months who can attend the examination site. Best corrected visual acuity in the best eye ranging from 20/60 to 20/400 and / or visual field&gt; 20º (monocular or binocular) with one of the following comorbidities: Stargardt&apos;s disease, Eye coloboma, Nystagmus, Aniridia, Retinopathy of Prematurity, Macular degeneration Age-related, Retinal Detachment, Diabetic Retinopathy, Uveitis and other infectious diseases, Cone dystrophy, Leber&apos;s Congenital Amaurosis, Pigmentary Retinosis, Optic Nerve Hypopasia, Glaucoma, Optic Nerve Atrophy, Neuropathy. The patient must accept to use eSight in varied situations that simulate everyday situations and in public environments, open and or closed or at the discretion of the investigator.	Visual acuity better corrected in the best eye better than 20/60. Inability to attend the examination site to perform it. Inability to understand the use of the equipment and to provide data to assess its use.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-43rj8f2	Anesthesia training	Not yet recruiting	Intervention	2021-10-14	<NULL>	<NULL>	4986	Simulation in anesthesiology	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-11-01	Escola Paulista de Medicina da Universidade Federal de São Paulo	Escola Paulista de Medicina da Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-43rj8f2	<NULL>	Volunteer medical students or medical residents or professors of anesthesiology; both sexes.	Volunteers under 18 years old.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-83px3n7	Effect of Clareon-toric intraocular lens position on vision after cataract surgery	Recruiting	Intervention	2021-10-14	<NULL>	<NULL>	4987	Effect of Clareon-toric intraocular lens position on post-operative refraction	<NULL>	3, single-arm-study, single-blind	3	<NULL>	<NULL>	<NULL>	2021-06-01	Hospital da clínicas da faculdade de medicina de Ribeirão Preto da universidade de São Paulo	Alcon Laboratórios do Brasil	https://ensaiosclinicos.gov.br/rg/RBR-83px3n7	<NULL>	Volunteers over 18 years old; both genders; cataract presence with formal indication for cataract surgery and corneal astigmatism greater than or equal to 1.0 diopter;.	Any eye disease other than cataracts and astigmatism; surgery or previous inflammation; preoperative refraction with spherical equivalent (refractive error) greater than +5.0 diopters or less than -5.0 diopters; irregular astigmatism; optic nerve or macular abnormalities detected with optical coherence tomography.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-74jjp56	Evaluation of the inflammatory index of the diet, microscopic analysis of visceral fat, and metabolic profile of obese adults undergoing Stomach Reduction surgery	Recruitment completed	Intervention	2021-10-14	<NULL>	<NULL>	4988	Evaluation of the dietary inflammatory index, histopathology of visceral adipose tissue, and metabolic profile of adults with obesity undergoing Bariatric and Metabolic surgery	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2019-09-02	Departamento de Biociências -Baixada Santista	Universidade Federal de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-74jjp56	<NULL>	Diagnosis of obesity and indication for bariatric and metabolic surgery; eutrophic participants with indication for cholecystectomy; age between 18 and 50 years; both sexes; body mass index greater than 40 kg/m² or greater than or equal to 35 kg/m² with comorbidities; body mass index between 18.5 and 24.9 kg/m² for the eutrophic control group.	Psychiatric disease; chronic alcoholism; history of kidney and heart disease; decompensated clinical illnesses; use of vitamin supplementation; diagnosis of obesity due to genetic diseases; individuals with walking disorders.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-6w3w5b4	The impact of training with tasks performed simultaneously on memory and risk of falls in older adults	Not yet recruiting	Intervention	2021-10-14	<NULL>	<NULL>	4989	The impact of dual task training on cognition and risk of falls in older adults	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-15	Universidade Federal de Mato Grosso do Sul	Universidade Federal de Mato Grosso do Sul	https://ensaiosclinicos.gov.br/rg/RBR-6w3w5b4	<NULL>	Elderly people with 60 years or more, without neurological and psychiatric disorders, living in the community.	Patients with cognitive decline, those with movement disorders, subjects with congenital or acquired amaurosis and those with severe cardiovascular and musculoskeletal comorbidities that preclude orthostatism and deambulation.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3v27w3s	Effects of regular, supervised weight-bearing exercise on muscle strength, control of glucose, triglyceride and cholesterol values and how this type of exercise relates to the amount of the hormone irisin in women with Type 2 Diabetes who have stopped menstruating of more than one year	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4978	Effects of Supervised Resistance Training on Muscle Strength, Metabolic Control, Quality of Life and its relation with Irisin in Postmenopausal Type 2 Diabetic women	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-01-02	Faculdade de Ciências Médicas de Pernambuco	PPGCS/UPE - Programa de Pós-Graduação em Ciências da Saúde	https://ensaiosclinicos.gov.br/rg/RBR-3v27w3s	<NULL>	Female patients; in the postmenopausal period; diagnosed with type 2 diabetes mellitus; with variations in glycosylated hemoglobin levels less than or equal to 11%; and are classified as being sedentary or irregularly active according to the International Physical Activity Questionnaire.	Past coronary or cerebrovascular event; carriers of chronic kidney disease with an estimated glomerular filtration rate less than or equal to 30 ml / min; orthopedic limitation for physical exercise; proliferative diabetic retinopathy; disabling diabetic neuropathy; NYHA class III or IV heart failure; established liver disease Child B or C classification; decompensated thyroid disease; malignant neoplasm, except for basal cell carcinoma; in coronary, carotid or peripheral arterial revascularization schedule; documented myocardial ischemia; classified as active or very active by the International Physical Activity Questionnaire; participation in any training program using weights in the last 6 months; and with adherence to the systematic resistance training protocol below 80%.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-5qh6f3v	The effect of physical exercise on the health of elderly people	Recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4979	Effects of Physical Exercise on physical and psychological health of Elderly	<NULL>	n/a, non-randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-07-01	Universidade do Estado de Santa Catarina - UDESC	Universidade do Estado de Santa Catarina - UDESC	https://ensaiosclinicos.gov.br/rg/RBR-5qh6f3v	<NULL>	Seniors aged over 60 years; male and female; Have internet access; Have the ability to understand cellphone use, as it will be the first form of contact, or have a responsible person who contributes to assisting the use; Ability to understand how to perform the exercises.	Unable to communicate via cell phone; Not understanding guidelines and not having someone responsible for providing assistance; Not having internet access; Elderly people who use some type of equipment to get around that prevents them from performing the exercises; Any physical or cognitive condition that limits the participant from performing the proposed exercises	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-97v22nw	Evaluation of the effectiveness of an ionic silver dressing on a burn victim	Recruitment completed	Intervention	2021-10-13	<NULL>	<NULL>	4980	Evaluation of the effectiveness of an ionic silver impregnated dressing on a burn victim	<NULL>	2-3, randomized-controlled, open	2-3	<NULL>	<NULL>	<NULL>	2017-10-01	Faculdade de medicina de Ribeirão Preto	Molnlycke Health Care Brazil	https://ensaiosclinicos.gov.br/rg/RBR-97v22nw	<NULL>	Age from 0 to 60 years; Burn of II and III degrees affecting the percentile between 10 to 30 percent of body surface burned; Burn in special areashands and feet; Patients at risk.	known allergy to dressing components;need to change the type of dressing during the study period; Isolated burns on the face, perineum or airways; Electrical burns	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-8bfznx6	Low-intensity laser in the healing of second-degree burns: randomized and controlled clinical trial	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4981	Phototherapy in Burns reepitization: randomized and controlled clinical trials	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-11-02	Universidade Federal da Paraíba	Universidade Federal da Paraíba	https://ensaiosclinicos.gov.br/rg/RBR-8bfznx6	<NULL>	Volunteers who have suffered second degree burns; over 18 years of age; of both sexes; with stable physical state; no pre-existing metabolic diseases; able to carry out physical therapy treatment; in good mental health; without the presence of infection in the injured tissues; without the use of medications that alter the healing process.	Volunteers who develop associated dermatological diseases or infectious processes will be excluded from the study, as well as those who do not complete the therapeutic or evaluation procedure and those who drop out of the study.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3r45cgs	Intervention to implement care monitoring for people living with HIV / AIDS	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4982	Intervention to implement continuous care monitoring for people living with HIV / AIDS	<NULL>	n/a, n/a, open	N/A	<NULL>	<NULL>	<NULL>	2022-02-15	Departamento de Medicina Preventiva da FMUSP	Centro de Referência e Treinamento DST/Aids - Coordenação do Programa IST/Aids SES-SP	https://ensaiosclinicos.gov.br/rg/RBR-3r45cgs	<NULL>	This implementation study will include 30 outpatient care services for people with HIV chosen for their size and complexity, necessarily belonging to the health regions of São Jose dos Campos, Sorocaba, Itapeva, Caraguatatuba, Ribeirão Preto and Taubaté; CD4 and viral load test requesters.	Outpatient services that do not care for people with HIV; outpatient services for people with HIV who are not requesting CD4 and Viral Loading; outpatient services for people with HIV of other health regions	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-7xzcmg7	Conventional Percutaneous surgery vs. Endoscopic Combined Intrarenal surgery for the treatment of large Kidney Stones	Not yet recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4983	Conventional percutaneous nephrolithotomy with flexible antegrade nephroscopy vs. Endoscopic Combined Intrarenal Surgery (ECIRS): a prospective randomized study	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-31	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-7xzcmg7	<NULL>	"Adults aged 18 or over with kidney stones greater than 20 mm, candidates for PCNL in Barts position; Signed informed consent	."	Impossibility to perform retrograde ureteroscopy (e.g., urinary reconstruction); Contraindications to PCNL (untreated urinary infection, uncorrected coagulopathy, ipsilateral kidney tumor, pregnancy); Concurrent ureteral stone or simultaneous bilateral approach; Uncontrolled comorbidities; Refusal to sign consent.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-46hscsv	Adherence and permanence to a physical exercise program by teleorientation in community-dwelling elderly	Recruiting	Intervention	2021-10-13	<NULL>	<NULL>	4984	Adherence and permanence to a physical exercise program by teleorientation in community-dwelling elderly	<NULL>	1, randomized-controlled, single-blind	1	<NULL>	<NULL>	<NULL>	2021-03-12	Universidade Federal de Ciências da Saúde de Porto Alegre	Universidade Federal de Ciências da Saúde de Porto Alegre	https://ensaiosclinicos.gov.br/rg/RBR-46hscsv	<NULL>	Be 60 years or older; Have access to the internet; Be physically independent; Being sedentary for at least 3 months; Respond to the call made through social networks; Reside in Porto Alegre or metropolitan area; Have availability to participate in the program on the days and times established; Achieve a minimum of 24 points in the mini-mental (in the case of less than 4 years of schooling, the cut-off point changes to 17).	Have physical limitations that make it impossible to perform the proposed exercises; Chronic uncontrolled diseases; Disabling pain.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3r92s4x	Effects of weight training, walking, and HIIT on health outcomes of sedentary women who are overweight or obese	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4969	Effects of weight training, walking and high intensity interval training on body composition, anthropometric measures, lipid profile, quality of life and other outcomes in sedentary women with overweight or obesity	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2022-04-04	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP/USP)	Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP/USP)	https://ensaiosclinicos.gov.br/rg/RBR-3r92s4x	<NULL>	Sedentary women, i.e., who have not practiced any type of physical exercise in the last 12 months for a period longer than 30 minutes per week; living in Uberaba, MG; aged between 35 and 45 years; BMI above 25 kg/m2; answering &quot;no&quot; to all items of the Physical Activity Readiness Questionnaire (PAR-Q); ability to walk without the aid of any devices	Current use of appetite suppressing or appetite-stimulating drugs; chronic conditions such as hypertension, diabetes, asthma, COPD; current smoking; being pregnant; weight loss or gain of more than 10% in the last six months, for any reason; treatment for cancer; any other conditions not provided for in the present study protocol that, in the opinion of the investigators, would adversely affect the conduct of the study and/or the safety of the participant	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-4dfxtmt	Effect of residency training on health and functionality in the elderly	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4970	The effectiveness of home based physical training on variables related to health and functional capacity of the elderly	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-10-13	Universidade Federal da Bahia	Universidade Federal da Bahia	https://ensaiosclinicos.gov.br/rg/RBR-4dfxtmt	<NULL>	seniors able to practice physical activity; over 60 years old; able to answer the study questionnaires and perform the proposed tests; have internet access	Elderly who have or acquire diseases and/or physical-motor and/or intellectual problems and symptoms that make it impossible to apply the questionnaires and/or perform evaluation tests and physical activities; seniors who do not attend at least 75% of classes	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-69zhsxr	"Effect of breathing exercises in patients with pulmonary diseases due to
non-tuberculous mycobacteria"	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4971	"Effect of respiratory physiotherapy in patients with pulmonary diseases due to
non-tuberculous mycobacteria"	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-12-01	UFCSPA - Universidade de Ciências da Saúde de Porto Alegre	Hospital Sanatório Partenon - Secretaria Estadual da Saúde do RS	https://ensaiosclinicos.gov.br/rg/RBR-69zhsxr	<NULL>	Patients at the Tuberculosis / MNT Outpatient Clinic of the Hospital Sanatório Partenon of the State Health Department; older than 18 years; who are able to carry out the exercises alone; using smartphones with Internet access	Recent history of hemoptysis; undergoing regular physical therapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-9v52jkd	Influence of body mass on the performance of tests that assess cognition	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4972	Influence of the quantity of body mass involved in the exercise on the performance of executive functions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-01	Faculdade de Educação Física e Dança (FEFD) da Universidade Federal de Goiás (UFG)	Faculdade de Educação Física e Dança (FEFD) da Universidade Federal de Goiás (UFG)	https://ensaiosclinicos.gov.br/rg/RBR-9v52jkd	<NULL>	Be literate (because there is a need for participants to answer questionnaires)	women who are pregnant and participants who have any contraindication for performing physical activity, verified by applying the Physical Activity Readiness Questionnaire/PAR-Q and using psychotropic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-67c7n8g	The Effects of Audiovisual Neurostimulation in women with Fibromyalgia	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4973	The Effects of audiovisual neurostimulation on Pain, quality of life, brain activity and inflammatory biochemical markers in women with Fibromyalgia: a randomized clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-10-11	Universidade do Sul de Santa Catarina	<NULL>	https://ensaiosclinicos.gov.br/rg/RBR-67c7n8g	<NULL>	Women with a clinical diagnosis of FM; living in the greater Florianópolis SC; aged between 18 and 80 years and undergoing pharmacological treatment.	Women with diseases that can be stimulated by light; with immunodepressive diseases; with oncological diseases; with infectious diseases or in a febrile state, epileptics; pregnant women; lactating women; women with symptoms or confirmation of COVID-19.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-4wzz4xy	Effectiveness of Bach Flower Therapy in reducing stress of nursing workers	Recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4974	Effectiveness of Bach Flower Therapy in reducing Stress of nursing workers	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-09-15	Escola de Enfermagem da Universidade de São Paulo	Secretaria Municipal de Saúde de Osasco	https://ensaiosclinicos.gov.br/rg/RBR-4wzz4xy	<NULL>	Volunteers who work in primary care nursing; have worked at the institution for at least six months; agree to use the floral formula as indicated	Volunteers diagnosed with or undergoing drug treatment for psychiatric illnesses; alcoholism self-report; being on vacation during the data collection period; use other integrative and complementary therapies during the research; have used Floral Therapy for less than six months ago	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-3xzcdky	The use of Cellular Proteins as Enhancers of Bone Formation in Bone Grafting.	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4975	Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting.	<NULL>	1-2, randomized-controlled, double-blind	1-2	<NULL>	<NULL>	<NULL>	2021-09-30	Pontifícia Universidade Católica do RIo Grande do Sul	Universidade Católica de Leuven	https://ensaiosclinicos.gov.br/rg/RBR-3xzcdky	<NULL>	Patients at least 35 years-old or older, presenting highly atrophic fully edentulous maxilla (residual alveolar bone height &lt;5 mm), requiring bilateral maxillary sinus augmentation and full mouth implant-supported rehabilitation; having teeth extraction at least 8 weeks prior to bone augmentation.	Smokers (more than 10 cigarettes a day), with a history of use or current use of illicit drugs and/or alcohol; patients with metabolic/systemic diseases that lead to impaired tissue healing (eg, decompensated diabetes, leukocyte or clotting disorders, immunosuppression); hx of previous radiotherapy in the head or neck region; receptors for bisphosphonate-based or steroid therapies; intolerant to general and/or local anesthesia.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-2nvbtvy	Effect of respiratory physiotherapy on the thoracoabdominal synchrony of premature newborn	Not yet recruiting	Intervention	2021-10-12	<NULL>	<NULL>	4976	Effect of respiratory physiotherapy on the thoracoabdominal synchrony of premature newborn - controlled clinical trial	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2022-02-20	Maternidade Instituto de Saúde Elpídio de Almeida- ISEA	Universidade Federal do Rio Grande do Norte	https://ensaiosclinicos.gov.br/rg/RBR-2nvbtvy	<NULL>	"RNPT; Who are in physiotherapeutic follow-up; indications for bronchial hygiene maneuvers in the presence of auscultation and/or mechanical ventilator charts showing changes suggestive of secretion; Only PTNB that are suitable for aspiration with a 6Fr gauge probe; Mothers aged 18 years and over; Only RNPT that are capable of aspiration with a 6Fr gauge probe.
·       Mothers aged 18 or over."	Present organic and structural changes, involving: chest deformities, necrotizing enterocolitis, skin lesion on the chest, hyperthermia, hypothermia, abdominal pathologies, congenital diaphragmatic hernia and the presence of a chest tube; PTNBs who do not complete any stage of the research procedure will also be excluded.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-5s6mnrf	Comparison between two techniques for correction of abdominal hernia in cancer patients	Data analysis completed	Intervention	2021-10-12	<NULL>	<NULL>	4977	Comparison between robot-assisted video laparoscopic Rives-Stoppa techniques in ventral incisional hernia repair in cancer patients: a prospective and randomized study	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2015-01-01	Faculdade de Medicina da Universidade de São Paulo	Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-5s6mnrf	<NULL>	Adult patients (18-65 years) with any abdominal or pelvic incisional hernia following oncologic surgery	Patients that were pregnant, were under systemic chemotherapy, or presented any contraindication to general anesthesia or laparoscopy intervention	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:49
RBR-62w7twc	The effect of meditation on stress among university students	Data analysis completed	Intervention	2021-10-11	<NULL>	<NULL>	4963	Evaluation of a meditation program on stress symptoms among undergraduate students: a randomised clinical trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2019-10-08	Centro de Estudos Superiores de Maceió - CESMAC	Centro de Estudos Superiores de Maceió - CESMAC	https://ensaiosclinicos.gov.br/rg/RBR-62w7twc	<NULL>	Students enrolled in medical and dental courses of the Centro Universitário CESMAC, that are over 18 years old, from both genders, for phase one. In phases two and three were included students enrolled in medical and dental courses of the Centro Universitário CESMAC, that are over 18 years old, from both genders, that have presented symptoms of Stress and/or anxiety measured by the STAI and LSSI.	To be enrolled in more than 1 graduation course besides medicine or odontology; having recieved a diagnosis or being in treatment for psychotic or dissociative disorders; have been exposed to any emotionally traumatic event such as accidents, physical or sexual violence, or death threats; do not show in one of the 2 schedulled encounters.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-39x8pbw	The masking effect of infiltrating resin applied to incisive molar hypomineralization lesions	Recruiting	Intervention	2021-10-11	<NULL>	<NULL>	4964	Infiltrating resin applies to mask Incisive molar hypomineralization injuries with different degrees of severity	<NULL>	4, single-arm-study, open	4	<NULL>	<NULL>	<NULL>	2021-06-01	Pontifícia Universidade Católica do Rio Grande do Sul	Pontifícia Universidade Católica do Rio Grande do Sul	https://ensaiosclinicos.gov.br/rg/RBR-39x8pbw	<NULL>	Molar incisor hypomineralizatoin in anterior teeth	Hypersensitivity	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-7scgp3h	Effect of chemical agents containing green tea and hyaluronic acid in controlling inflammation and bacterial plaque around teeth and implants.	Recruiting	Intervention	2021-10-11	<NULL>	<NULL>	4965	Effect of chemical agents containing green tea and hyaluronic acid, in dentifrice and mouthwash formulations, on periodontal and peri-implant clinical parameters. A Randomized Controlled clinical trials.	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-08-01	Universidade Federal de Uberlândia	New Detal Care LTDA	https://ensaiosclinicos.gov.br/rg/RBR-7scgp3h	<NULL>	Patients with dental implant in partial or single rehabilitation with permanent dentures installed for at least 6 months; age group from 18 to 60 years old; systemically healthy	Smokers; uncontrolled diabetics; history of radiotherapy or chemotherapy	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-6wryhb9	Effects of different methods to treat myofascial pain	Not yet recruiting	Intervention	2021-10-11	<NULL>	<NULL>	4966	Effects of different methods to treat myofascial trigger points: randomized controlled trial	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2022-07-04	Universidade Estadual Paulista, Instituto de Biociências	Universidade Estadual Paulista	https://ensaiosclinicos.gov.br/rg/RBR-6wryhb9	<NULL>	Both genders; between 18 to 40 years old; presence of trigger points in the musculature; physically active; signed the statement of informed consent	Body Mass Index (BMI) above 30; have used analgesic, anti-inflammatory, anticoagulant, muscle relaxant or antipyretic medications up to 24 hours before; needle phobia; pregnant women; performed strenuous exercises or used stimulants 24 hours before; sensitivity or mental disorders diagnosed	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-5k9ppgx	Pain control after root canal treatment, after filling the root canals with a new bioceramic cement, called bc sealer hi-flow : a study with random selection of analyzed groups	Recruiting	Intervention	2021-10-11	<NULL>	<NULL>	4968	Postoperative pain assessment after root canal sealing with the new bioceramic bc sealer Hi-flow: A prospective randomized clinical trial	<NULL>	n/a, randomized-controlled, open	N/A	<NULL>	<NULL>	<NULL>	2021-06-01	Cristiane da Silva Gomes Bezerra	Faculdade São Leopoldo Mandic	https://ensaiosclinicos.gov.br/rg/RBR-5k9ppgx	<NULL>	We will select older patients who have teeth from the central incisor groups and upper lateral incisors with indication for placement of prostheses and teeth that clinically and radiographically present altered physiology such as irreversible pulpitis and pulp necrosis. They need to be healthy; both genders; non smokers.	Patients under 18 years of age; teeth with immature apex; showing root resorptions; teeth that could not be isolated; people with cognitive difficulties; pregnant women; smokers; patients who have an excessive consumption of alcohol; patients with uncontrolled diabetes and hypertension. Patients who cannot perform the treatment in a single session. Who have taken medication 7 days prior to treatment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-6d6gxxz	Evaluation of a bulk-fill thermoviscous composite resin in dental restoration	Recruitment completed	Intervention	2021-10-11	<NULL>	<NULL>	5292	Clinical evaluation of a thermoviscous bulk-fill composite restorations in non-carious cervical lesions	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	Universidade Estadual de Ponta Grossa	Universidade Estadual de Ponta Grossa	https://ensaiosclinicos.gov.br/rg/RBR-6d6gxxz	<NULL>	Good general health, good oral hygiene, have at least 20 teeth under occlusion. At least two comparable LCNCs (in size, shape and dimensions), non-retentive, deeper than 0.5 mm, and involving both enamel and dentin of vital teeth. The cavo-superficial margin cannot involve more than 50% of the enamel.	Extremely poor oral hygiene, using orthodontic devices, severe or chronic periodontitis, heavy bruxism habits. Known allergy to resin-based materials or any other material used in this study. Pregnant or lactating women, chronic use of anti-inflammatory, analgesic and psychotropic drugs.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:21:00
RBR-4npsyxz	Impact of pyelonephritis on the activity of renal drug transporters in pregnant women.	Recruiting	Intervention	2021-10-10	<NULL>	<NULL>	4956	Pyelonephritis impacts on organic anion transporters (OAT) 1 and 3 activity in pregnant women: a quantitative system pharmacology approach	<NULL>	4, non-randomized-controlled, open	4	<NULL>	<NULL>	<NULL>	2019-09-26	Faculdade de Ciências Farmacêuticas de Ribeirão Preto	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo	https://ensaiosclinicos.gov.br/rg/RBR-4npsyxz	<NULL>	Pregnant women over the age of 18 will be investigated, diagnosed with pyelonephritis and with indication for treatment with antibiotics, seen at HC-FMRPUSP. Additionally, healthy pregnant patients will be recruited at the Women&apos;s Health of Ribeirão Preto-Mater (CRSMRP-Mater) and in the following basic units of health and municipal community medical centers Centro Médico Social Comunitário Vila Lobato; CSE Ipiranga / Dr Edgard Aché; UBS Dom Mielle / Prof. Dr. Aymar Baptista Prado; UBS Jardim Presidente Dutra / Dr. Sérgio Botelho da Costa Moares; USD Maria Casagrande Lopes / Ernesto Che Guevara; USF Vila Albertina / Dr. Álvaro Panazzolo; UBS Vila Tibério / Wilma Delphina by O. Garotti; UBS Bonfim Paulista / Mamoro Kobayashi and UBS Santa Cruz / Helio Lourenço de Oliveira and healthy non-pregnant volunteers from the Campus of the University of São Paulo, Campus of Ribeirão Preto. Pregnant patients of both protocols will be included in the study during the second and third quarters of the gestation	"Pregnant women diagnosed with pyelonephritis will be excluded from the study when
present at least one of the following diseases: chronic renal failure, syndromes
hypertensive (chronic arterial hypertension and / or pre-eclampsia), chronic fetal distress and systemic lupus erythematosus. Healthy pregnant women and healthy non-pregnant volunteers will be excluded from the protocol when using OAT-inhibiting / inducing drugs, which may interact with furosemide or probenecid: amino salicylic acid, para-aminohipuric acid, citalopram, cholestyramine, escitalopram, diclofenac, digoxin , lithium, linezolid,
rifampin, rifabutin, rifapentin, sertraline and teriflunomide."	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-6w8cwxc	The use of music to reduce parental stress in premature babies hospitalized	Recruiting	Intervention	2021-10-10	<NULL>	<NULL>	4957	The use of music to reduce parental stress in premature babies hospitalized	<NULL>	n/a, randomized-controlled, single-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-01	universidade Estadual de Londrina	universidade Estadual de Londrina	https://ensaiosclinicos.gov.br/rg/RBR-6w8cwxc	<NULL>	Fathers and mothers with premature newborns with a gestational age of less than 34 weeks admitted to the NICU, under invasive ventilation.	Fathers and mothers of premature newborns, who have children with congenital malformations or whose newborns need palliative care. Fathers and mothers who do not wish to assume parenthood or motherhood. Fathers and mothers who have a hearing impairment.	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-5vsm8t7	Effect of timing of beetroot juice ingestion on magnitude and duration of post-exercise hypotension in hypertensive patients	Recruiting	Intervention	2021-10-10	<NULL>	<NULL>	4958	Effect of timing of beetroot juice ingestion on magnitude and duration of post-exercise hypotension in hypertensive patients	<NULL>	n/a, randomized-controlled, double-blind	N/A	<NULL>	<NULL>	<NULL>	2021-05-03	Ufpb - Universidade Federal da Paraiba	Ufpb - Universidade Federal da Paraiba	https://ensaiosclinicos.gov.br/rg/RBR-5vsm8t7	<NULL>	"Volunteers diagnosed with hypertension according to the seventh Brazilian Guidelines on Hypertension; with SBP between 130 and 160 mmHg and DBP between 85 and 90 mmHg; using antihypertensive drugs; except for the beta-blocker class; are not assiduous consumers of
beetroot; have a recent history in the last month of performing aerobic exercises with
sessions of at least 60 minutes; not being a smoker and being able to carry out the protocol of
physical exercise"	Volunteers who do not participate in all experimental procedures; present gastrointestinal discomfort to beetroot juice or control drink; change the medication, diet or physical training pattern during the experimental procedures	<NULL>	<NULL>	<NULL>	<NULL>		2026-05-11 05:20:48
RBR-2fxs983	Device training increases the volume of air ent