ECRI — Methodology & Disclosure

What the model estimates

Execution costs inferred from published or transparently adjusted benchmark parameters. These values are not audited actual expenditure, trial funding, market size or total development cost.

Formula: C = F + N × P + S × A + M + L.

F: fixed startup/administration; N: target participants; P: variable cost per participant; S: sites; A: fixed cost per site; M: monitoring/data management; L: logistics and study-specific costs.

Inputs are selected by validated applicability. Overlapping cost scopes are rejected to prevent double counting. Missing site or participant information is never interpreted as zero. Lower/upper values, where supported, are sensitivity bounds, not confidence intervals.