| The study will include women aged 35 to 65 years with skin phototypes I through IV on the Fitzpatrick skin phototype scale; who have a degree of photoaging of II through IV according to the Glogau Scale; report dissatisfaction with signs of facial aging such as wrinkles, fine lines, and loss of firmness; are capable of understanding all procedures, risks, and benefits of the study, and agree to read and sign the informed consent form before any research-related procedure, as well as express willingness and availability to attend all treatment sessions and scheduled follow-up visits. | |
| Participants who have active dermatological conditions such as active skin infections (bacterial, viral such as active herpes simplex, or fungal), dermatitis, psoriasis, active rosacea, inflammatory acne (grade III or IV), or any other inflammatory condition on the face; have a personal history of abnormal scarring such as hypertrophic scarring or keloid formation; are pregnant, suspect they are pregnant, are planning to become pregnant during the study, or are breastfeeding; have serious or uncontrolled systemic diseases such as uncontrolled diabetes mellitus, uncontrolled hypertension, decompensated thyroid disease, or any systemic disease that, at the researchers' discretion, may interfere with the safety or results of the study; have autoimmune and collagen diseases with cutaneous manifestations or that affect connective tissue (e.g., systemic lupus erythematosus, scleroderma, dermatomyositis); have a diagnosis of immunodeficiency (congenital or acquired, such as HIV) or are chronically using immunosuppressant medications or systemic corticosteroids; are using specific medications such as oral isotretinoin in the last 12 months; oral anticoagulants or antiplatelet agents that cannot be safely discontinued (at the discretion of the participant's attending physician); are using any medications that may affect the bleeding or coagulation mechanism; have undergone certain previous aesthetic procedures (washout period) on the face, such as microneedling, ablative laser, medium/deep chemical peeling, or facial surgery in the last 12 months; have had dermal fillers or thread lifts in the area in the last 12 months, have had botulinum toxin injections in the area in the last 6 months, and have undergone treatments with non-ablative lasers, radiofrequency, or microfocused ultrasound in the area in the last 6 months; participants are allergic to any component of the products and materials to be used in the study, including topical anesthetics (e.g., lidocaine), metals (e.g., surgical steel needles), or the active ingredient to be used in the session, and those who are excessively exposed to the sun or refuse to adhere to sun protection during the study. | |